Antioxidant potential of a polyherbal antimalarial as an indicator of its therapeutic value.
Identifieur interne : 000502 ( PubMed/Corpus ); précédent : 000501; suivant : 000503Antioxidant potential of a polyherbal antimalarial as an indicator of its therapeutic value.
Auteurs : Protus Arrey Tarkang ; Achille Parfait Nwachiban Atchan ; Jules-Roger Kuiate ; Faith Apoelot Okalebo ; Anastasia Nkatha Guantai ; Gabriel Agbor AgborSource :
- Advances in pharmacological sciences [ 1687-6334 ] ; 2013.
Abstract
Nefang is a polyherbal product composed of Mangifera indica (bark and leaf), Psidium guajava, Carica papaya, Cymbopogon citratus, Citrus sinensis, and Ocimum gratissimum (leaves), used for the treatment of malaria. Compounds with antioxidant activity are believed to modulate plasmodial infection. Antioxidant activity of the constituent aqueous plants extracts, in vitro, was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH), total phenolic content (TPC), and ferric reducing antioxidant power (FRAP) methods and, in vivo, Nefang (100 and 500 mg kg(-1)) activity was evaluated in carbon tetrachloride-induced oxidative stressed Wistar rats. Superoxide dismutase, catalase activities, and lipid peroxidation by the malondialdehyde and total proteins assays were carried out. P. guajava, M. indica leaf, and bark extracts had the highest antioxidant properties in all three assays, with no statistically significant difference. Rats treated with the carbon tetrachloride had a statistically significant decrease in levels of triglycerides, superoxide dismutase, and catalase (P < 0.05) and increase in malondialdehyde activity, total protein levels, and liver and renal function markers, whereas rats treated with Nefang showed increased levels in the former and dose-dependent decrease towards normal levels in the later. These results reveal the constituent plants of Nefang that contribute to its in vivo antioxidant potential. This activity is a good indication of the therapeutic potential of Nefang.
DOI: 10.1155/2013/678458
PubMed: 24454347
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Box 67, Dschang, Cameroon.</nlm:affiliation></affiliation></author><author><name sortKey="Kuiate, Jules Roger" sort="Kuiate, Jules Roger" uniqKey="Kuiate J" first="Jules-Roger" last="Kuiate">Jules-Roger Kuiate</name><affiliation><nlm:affiliation>Department of Biochemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon.</nlm:affiliation></affiliation></author><author><name sortKey="Okalebo, Faith Apoelot" sort="Okalebo, Faith Apoelot" uniqKey="Okalebo F" first="Faith Apoelot" last="Okalebo">Faith Apoelot Okalebo</name><affiliation><nlm:affiliation>Department of Pharmacology and Pharmacognosy, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya.</nlm:affiliation></affiliation></author><author><name sortKey="Guantai, Anastasia Nkatha" sort="Guantai, Anastasia Nkatha" uniqKey="Guantai A" first="Anastasia Nkatha" last="Guantai">Anastasia Nkatha Guantai</name><affiliation><nlm:affiliation>Department of Pharmacology and Pharmacognosy, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya.</nlm:affiliation></affiliation></author><author><name sortKey="Agbor, Gabriel Agbor" sort="Agbor, Gabriel Agbor" uniqKey="Agbor G" first="Gabriel Agbor" last="Agbor">Gabriel Agbor Agbor</name><affiliation><nlm:affiliation>Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaoundé, Cameroon.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24454347</idno><idno type="pmid">24454347</idno><idno type="doi">10.1155/2013/678458</idno><idno type="wicri:Area/PubMed/Corpus">000502</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antioxidant potential of a polyherbal antimalarial as an indicator of its therapeutic value.</title><author><name sortKey="Arrey Tarkang, Protus" sort="Arrey Tarkang, Protus" uniqKey="Arrey Tarkang P" first="Protus" last="Arrey Tarkang">Protus Arrey Tarkang</name><affiliation><nlm:affiliation>Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaoundé, Cameroon ; Department of Pharmacology and Pharmacognosy, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya.</nlm:affiliation></affiliation></author><author><name sortKey="Nwachiban Atchan, Achille Parfait" sort="Nwachiban Atchan, Achille Parfait" uniqKey="Nwachiban Atchan A" first="Achille Parfait" last="Nwachiban Atchan">Achille Parfait Nwachiban Atchan</name><affiliation><nlm:affiliation>Department of Biochemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon.</nlm:affiliation></affiliation></author><author><name sortKey="Kuiate, Jules Roger" sort="Kuiate, Jules Roger" uniqKey="Kuiate J" first="Jules-Roger" last="Kuiate">Jules-Roger Kuiate</name><affiliation><nlm:affiliation>Department of Biochemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon.</nlm:affiliation></affiliation></author><author><name sortKey="Okalebo, Faith Apoelot" sort="Okalebo, Faith Apoelot" uniqKey="Okalebo F" first="Faith Apoelot" last="Okalebo">Faith Apoelot Okalebo</name><affiliation><nlm:affiliation>Department of Pharmacology and Pharmacognosy, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya.</nlm:affiliation></affiliation></author><author><name sortKey="Guantai, Anastasia Nkatha" sort="Guantai, Anastasia Nkatha" uniqKey="Guantai A" first="Anastasia Nkatha" last="Guantai">Anastasia Nkatha Guantai</name><affiliation><nlm:affiliation>Department of Pharmacology and Pharmacognosy, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya.</nlm:affiliation></affiliation></author><author><name sortKey="Agbor, Gabriel Agbor" sort="Agbor, Gabriel Agbor" uniqKey="Agbor G" first="Gabriel Agbor" last="Agbor">Gabriel Agbor Agbor</name><affiliation><nlm:affiliation>Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaoundé, Cameroon.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Advances in pharmacological sciences</title><idno type="ISSN">1687-6334</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nefang is a polyherbal product composed of Mangifera indica (bark and leaf), Psidium guajava, Carica papaya, Cymbopogon citratus, Citrus sinensis, and Ocimum gratissimum (leaves), used for the treatment of malaria. Compounds with antioxidant activity are believed to modulate plasmodial infection. Antioxidant activity of the constituent aqueous plants extracts, in vitro, was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH), total phenolic content (TPC), and ferric reducing antioxidant power (FRAP) methods and, in vivo, Nefang (100 and 500 mg kg(-1)) activity was evaluated in carbon tetrachloride-induced oxidative stressed Wistar rats. Superoxide dismutase, catalase activities, and lipid peroxidation by the malondialdehyde and total proteins assays were carried out. P. guajava, M. indica leaf, and bark extracts had the highest antioxidant properties in all three assays, with no statistically significant difference. Rats treated with the carbon tetrachloride had a statistically significant decrease in levels of triglycerides, superoxide dismutase, and catalase (P < 0.05) and increase in malondialdehyde activity, total protein levels, and liver and renal function markers, whereas rats treated with Nefang showed increased levels in the former and dose-dependent decrease towards normal levels in the later. These results reveal the constituent plants of Nefang that contribute to its in vivo antioxidant potential. This activity is a good indication of the therapeutic potential of Nefang.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">24454347</PMID><DateCreated><Year>2014</Year><Month>1</Month><Day>23</Day></DateCreated><DateCompleted><Year>2014</Year><Month>01</Month><Day>23</Day></DateCompleted><DateRevised><Year>2014</Year><Month>1</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1687-6334</ISSN><JournalIssue CitedMedium="Print"><Volume>2013</Volume><PubDate><Year>2013</Year></PubDate></JournalIssue><Title>Advances in pharmacological sciences</Title><ISOAbbreviation>Adv Pharmacol Sci</ISOAbbreviation></Journal><ArticleTitle>Antioxidant potential of a polyherbal antimalarial as an indicator of its therapeutic value.</ArticleTitle><Pagination><MedlinePgn>678458</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1155/2013/678458</ELocationID><Abstract><AbstractText>Nefang is a polyherbal product composed of Mangifera indica (bark and leaf), Psidium guajava, Carica papaya, Cymbopogon citratus, Citrus sinensis, and Ocimum gratissimum (leaves), used for the treatment of malaria. Compounds with antioxidant activity are believed to modulate plasmodial infection. Antioxidant activity of the constituent aqueous plants extracts, in vitro, was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH), total phenolic content (TPC), and ferric reducing antioxidant power (FRAP) methods and, in vivo, Nefang (100 and 500 mg kg(-1)) activity was evaluated in carbon tetrachloride-induced oxidative stressed Wistar rats. Superoxide dismutase, catalase activities, and lipid peroxidation by the malondialdehyde and total proteins assays were carried out. P. guajava, M. indica leaf, and bark extracts had the highest antioxidant properties in all three assays, with no statistically significant difference. Rats treated with the carbon tetrachloride had a statistically significant decrease in levels of triglycerides, superoxide dismutase, and catalase (P < 0.05) and increase in malondialdehyde activity, total protein levels, and liver and renal function markers, whereas rats treated with Nefang showed increased levels in the former and dose-dependent decrease towards normal levels in the later. These results reveal the constituent plants of Nefang that contribute to its in vivo antioxidant potential. This activity is a good indication of the therapeutic potential of Nefang.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Arrey Tarkang</LastName><ForeName>Protus</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaoundé, Cameroon ; Department of Pharmacology and Pharmacognosy, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nwachiban Atchan</LastName><ForeName>Achille Parfait</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuiate</LastName><ForeName>Jules-Roger</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Okalebo</LastName><ForeName>Faith Apoelot</ForeName><Initials>FA</Initials><AffiliationInfo><Affiliation>Department of Pharmacology and Pharmacognosy, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guantai</LastName><ForeName>Anastasia Nkatha</ForeName><Initials>AN</Initials><AffiliationInfo><Affiliation>Department of Pharmacology and Pharmacognosy, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Agbor</LastName><ForeName>Gabriel Agbor</ForeName><Initials>GA</Initials><AffiliationInfo><Affiliation>Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaoundé, Cameroon.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>Dec</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Adv Pharmacol Sci</MedlineTA><NlmUniqueID>101537654</NlmUniqueID><ISSNLinking>1687-6334</ISSNLinking></MedlineJournalInfo><OtherID Source="NLM">PMC3880729</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>8</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>10</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>10</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>1</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>1</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>1</Month><Day>24</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24454347</ArticleId><ArticleId IdType="doi">10.1155/2013/678458</ArticleId><ArticleId IdType="pmc">PMC3880729</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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