Citrus peel extract attenuates acute cyanide poisoning-induced seizures and oxidative stress in rats.
Identifieur interne : 000391 ( PubMed/Corpus ); précédent : 000390; suivant : 000392Citrus peel extract attenuates acute cyanide poisoning-induced seizures and oxidative stress in rats.
Auteurs : Ahmed E. Abdel MoneimSource :
- CNS & neurological disorders drug targets [ 1996-3181 ] ; 2014.
English descriptors
- KwdEn :
- Acetylcholinesterase (metabolism), Animals, Cerebral Cortex (drug effects), Cerebral Cortex (pathology), Cerebral Cortex (physiopathology), Citrus sinensis, Corpus Striatum (drug effects), Corpus Striatum (pathology), Corpus Striatum (physiopathology), Dopamine (metabolism), Fruit, Glutamic Acid (metabolism), Hippocampus (drug effects), Hippocampus (pathology), Hippocampus (physiopathology), Lipid Peroxidation (drug effects), Lipid Peroxidation (physiology), Male, Neuroprotective Agents (pharmacology), Nitric Oxide (metabolism), Norepinephrine (metabolism), Oxidative Stress (drug effects), Oxidative Stress (physiology), Phytotherapy, Plant Extracts (therapeutic use), Potassium Cyanide (poisoning), Rats, Wistar, Seizures (chemically induced), Seizures (drug therapy), Seizures (pathology), Seizures (physiopathology), Serotonin Plasma Membrane Transport Proteins (metabolism).
- MESH :
- chemical , metabolism : Acetylcholinesterase, Dopamine, Glutamic Acid, Nitric Oxide, Norepinephrine, Serotonin Plasma Membrane Transport Proteins.
- chemically induced : Seizures.
- drug effects : Cerebral Cortex, Corpus Striatum, Hippocampus, Lipid Peroxidation, Oxidative Stress.
- drug therapy : Seizures.
- pathology : Cerebral Cortex, Corpus Striatum, Hippocampus, Seizures.
- chemical , pharmacology : Neuroprotective Agents.
- physiology : Lipid Peroxidation, Oxidative Stress.
- physiopathology : Cerebral Cortex, Corpus Striatum, Hippocampus, Seizures.
- chemical , poisoning : Potassium Cyanide.
- chemical , therapeutic use : Plant Extracts.
- Animals, Citrus sinensis, Fruit, Male, Phytotherapy, Rats, Wistar.
Abstract
The primary aimed of this study was to investigate the potential protective effects of methanolic extract of citrus peel (MECP) on acute cyanide (KCN) poisoning-induced seizures and oxidative stress in rats. The intraperitoneal LD50 value of KCN (6.3 mg/Kg bwt), based on 24 hrs mortality, was significantly increased by 9, 52 or 113% by oral administration of MECP (500 mg/Kg bwt) pre-administered for 1, 2 and 3 days, respectively, in rats in a time-dependent manner. Intraperitoneal injection of the sublethal dose of KCN (3 mg/Kg bwt) into rats increased, 24 hrs later, lipid peroxidation (LPO), nitric oxide (NO), glutamate levels and acetylcholinesterase (AChE) activity in hippocampus, striatum and cerebral cortex. KCN also decreased brain glutathione (GSH) level and superoxide dismutase (SOD) and catalase (CAT) activities in these animals. Pre-treatment of rats with MECP inhibited KCN-induced increases in LPO, NO, and glutamate levels and AChE activity as well as decreases in brain GSH level and SOD and CAT activities. In addition, KCN significantly decreased norepinephrine, dopamine and serotonin levels in different brain regions which were resolved by MECP. From the present results, it can be concluded that the neuroprotective effects of MECP against KCN-induced seizures and oxidative stress may be due to the inhibition of oxidative stress overproduction and maintenance of antioxidant defense mechanisms.
PubMed: 24308563
Links to Exploration step
pubmed:24308563Le document en format XML
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<author><name sortKey="Abdel Moneim, Ahmed E" sort="Abdel Moneim, Ahmed E" uniqKey="Abdel Moneim A" first="Ahmed E" last="Abdel Moneim">Ahmed E. Abdel Moneim</name>
<affiliation><nlm:affiliation>Department of Zoology and Entomology, Faculty of Science, Helwan University, 11795 Helwan, Cairo, Egypt. aest1977@helwan.edu.eg.</nlm:affiliation>
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<author><name sortKey="Abdel Moneim, Ahmed E" sort="Abdel Moneim, Ahmed E" uniqKey="Abdel Moneim A" first="Ahmed E" last="Abdel Moneim">Ahmed E. Abdel Moneim</name>
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<term>Animals</term>
<term>Cerebral Cortex (drug effects)</term>
<term>Cerebral Cortex (pathology)</term>
<term>Cerebral Cortex (physiopathology)</term>
<term>Citrus sinensis</term>
<term>Corpus Striatum (drug effects)</term>
<term>Corpus Striatum (pathology)</term>
<term>Corpus Striatum (physiopathology)</term>
<term>Dopamine (metabolism)</term>
<term>Fruit</term>
<term>Glutamic Acid (metabolism)</term>
<term>Hippocampus (drug effects)</term>
<term>Hippocampus (pathology)</term>
<term>Hippocampus (physiopathology)</term>
<term>Lipid Peroxidation (drug effects)</term>
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<term>Norepinephrine (metabolism)</term>
<term>Oxidative Stress (drug effects)</term>
<term>Oxidative Stress (physiology)</term>
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<term>Plant Extracts (therapeutic use)</term>
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<term>Oxidative Stress</term>
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<term>Corpus Striatum</term>
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<term>Hippocampus</term>
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<keywords scheme="MESH" type="chemical" qualifier="poisoning" xml:lang="en"><term>Potassium Cyanide</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Plant Extracts</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Citrus sinensis</term>
<term>Fruit</term>
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<front><div type="abstract" xml:lang="en">The primary aimed of this study was to investigate the potential protective effects of methanolic extract of citrus peel (MECP) on acute cyanide (KCN) poisoning-induced seizures and oxidative stress in rats. The intraperitoneal LD50 value of KCN (6.3 mg/Kg bwt), based on 24 hrs mortality, was significantly increased by 9, 52 or 113% by oral administration of MECP (500 mg/Kg bwt) pre-administered for 1, 2 and 3 days, respectively, in rats in a time-dependent manner. Intraperitoneal injection of the sublethal dose of KCN (3 mg/Kg bwt) into rats increased, 24 hrs later, lipid peroxidation (LPO), nitric oxide (NO), glutamate levels and acetylcholinesterase (AChE) activity in hippocampus, striatum and cerebral cortex. KCN also decreased brain glutathione (GSH) level and superoxide dismutase (SOD) and catalase (CAT) activities in these animals. Pre-treatment of rats with MECP inhibited KCN-induced increases in LPO, NO, and glutamate levels and AChE activity as well as decreases in brain GSH level and SOD and CAT activities. In addition, KCN significantly decreased norepinephrine, dopamine and serotonin levels in different brain regions which were resolved by MECP. From the present results, it can be concluded that the neuroprotective effects of MECP against KCN-induced seizures and oxidative stress may be due to the inhibition of oxidative stress overproduction and maintenance of antioxidant defense mechanisms.</div>
</front>
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<Abstract><AbstractText>The primary aimed of this study was to investigate the potential protective effects of methanolic extract of citrus peel (MECP) on acute cyanide (KCN) poisoning-induced seizures and oxidative stress in rats. The intraperitoneal LD50 value of KCN (6.3 mg/Kg bwt), based on 24 hrs mortality, was significantly increased by 9, 52 or 113% by oral administration of MECP (500 mg/Kg bwt) pre-administered for 1, 2 and 3 days, respectively, in rats in a time-dependent manner. Intraperitoneal injection of the sublethal dose of KCN (3 mg/Kg bwt) into rats increased, 24 hrs later, lipid peroxidation (LPO), nitric oxide (NO), glutamate levels and acetylcholinesterase (AChE) activity in hippocampus, striatum and cerebral cortex. KCN also decreased brain glutathione (GSH) level and superoxide dismutase (SOD) and catalase (CAT) activities in these animals. Pre-treatment of rats with MECP inhibited KCN-induced increases in LPO, NO, and glutamate levels and AChE activity as well as decreases in brain GSH level and SOD and CAT activities. In addition, KCN significantly decreased norepinephrine, dopamine and serotonin levels in different brain regions which were resolved by MECP. From the present results, it can be concluded that the neuroprotective effects of MECP against KCN-induced seizures and oxidative stress may be due to the inhibition of oxidative stress overproduction and maintenance of antioxidant defense mechanisms.</AbstractText>
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