Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease.
Identifieur interne : 000181 ( PubMed/Corpus ); précédent : 000180; suivant : 000182Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease.
Auteurs : Manuel Y. Sch R ; Peter J. Curtis ; Sara Hazim ; Luisa M. Ostertag ; Colin D. Kay ; John F. Potter ; Aedín CassidySource :
- The American journal of clinical nutrition [ 1938-3207 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Beverages (analysis), Biomarkers (blood), Cardiovascular Diseases (prevention & control), Cardiovascular System (drug effects), Cardiovascular System (metabolism), Chromatography, High Pressure Liquid, Citrus sinensis (chemistry), Cross-Over Studies, Dietary Supplements, Hesperidin (administration & dosage), Hesperidin (blood), Humans, Male, Middle Aged, Phenols (administration & dosage), Phenols (blood), Risk Factors.
- MESH :
- chemical , administration & dosage : Hesperidin, Phenols.
- chemical , blood : Biomarkers, Hesperidin, Phenols.
- analysis : Beverages.
- chemistry : Citrus sinensis.
- drug effects : Cardiovascular System.
- metabolism : Cardiovascular System.
- prevention & control : Cardiovascular Diseases.
- Aged, Chromatography, High Pressure Liquid, Cross-Over Studies, Dietary Supplements, Humans, Male, Middle Aged, Risk Factors.
Abstract
Epidemiologic data suggest inverse associations between citrus flavanone intake and cardiovascular disease (CVD) risk. However, insufficient randomized controlled trial data limit our understanding of the mechanisms by which flavanones and their metabolites potentially reduce cardiovascular risk factors.
DOI: 10.3945/ajcn.114.104364
PubMed: 25788001
Links to Exploration step
pubmed:25788001Le document en format XML
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Curtis</name><affiliation><nlm:affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Hazim, Sara" sort="Hazim, Sara" uniqKey="Hazim S" first="Sara" last="Hazim">Sara Hazim</name><affiliation><nlm:affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Ostertag, Luisa M" sort="Ostertag, Luisa M" uniqKey="Ostertag L" first="Luisa M" last="Ostertag">Luisa M. Ostertag</name><affiliation><nlm:affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Kay, Colin D" sort="Kay, Colin D" uniqKey="Kay C" first="Colin D" last="Kay">Colin D. Kay</name><affiliation><nlm:affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Potter, John F" sort="Potter, John F" uniqKey="Potter J" first="John F" last="Potter">John F. Potter</name><affiliation><nlm:affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Cassidy, Aedin" sort="Cassidy, Aedin" uniqKey="Cassidy A" first="Aedín" last="Cassidy">Aedín Cassidy</name><affiliation><nlm:affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25788001</idno><idno type="pmid">25788001</idno><idno type="doi">10.3945/ajcn.114.104364</idno><idno type="wicri:Area/PubMed/Corpus">000181</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease.</title><author><name sortKey="Sch R, Manuel Y" sort="Sch R, Manuel Y" uniqKey="Sch R M" first="Manuel Y" last="Sch R">Manuel Y. Sch R</name><affiliation><nlm:affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Curtis, Peter J" sort="Curtis, Peter J" uniqKey="Curtis P" first="Peter J" last="Curtis">Peter J. Curtis</name><affiliation><nlm:affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Hazim, Sara" sort="Hazim, Sara" uniqKey="Hazim S" first="Sara" last="Hazim">Sara Hazim</name><affiliation><nlm:affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Ostertag, Luisa M" sort="Ostertag, Luisa M" uniqKey="Ostertag L" first="Luisa M" last="Ostertag">Luisa M. Ostertag</name><affiliation><nlm:affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Kay, Colin D" sort="Kay, Colin D" uniqKey="Kay C" first="Colin D" last="Kay">Colin D. Kay</name><affiliation><nlm:affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Potter, John F" sort="Potter, John F" uniqKey="Potter J" first="John F" last="Potter">John F. Potter</name><affiliation><nlm:affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Cassidy, Aedin" sort="Cassidy, Aedin" uniqKey="Cassidy A" first="Aedín" last="Cassidy">Aedín Cassidy</name><affiliation><nlm:affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The American journal of clinical nutrition</title><idno type="eISSN">1938-3207</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Beverages (analysis)</term><term>Biomarkers (blood)</term><term>Cardiovascular Diseases (prevention & control)</term><term>Cardiovascular System (drug effects)</term><term>Cardiovascular System (metabolism)</term><term>Chromatography, High Pressure Liquid</term><term>Citrus sinensis (chemistry)</term><term>Cross-Over Studies</term><term>Dietary Supplements</term><term>Hesperidin (administration & dosage)</term><term>Hesperidin (blood)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Phenols (administration & dosage)</term><term>Phenols (blood)</term><term>Risk Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Hesperidin</term><term>Phenols</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Hesperidin</term><term>Phenols</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Beverages</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cardiovascular System</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cardiovascular System</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Cardiovascular Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Chromatography, High Pressure Liquid</term><term>Cross-Over Studies</term><term>Dietary Supplements</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Epidemiologic data suggest inverse associations between citrus flavanone intake and cardiovascular disease (CVD) risk. However, insufficient randomized controlled trial data limit our understanding of the mechanisms by which flavanones and their metabolites potentially reduce cardiovascular risk factors.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25788001</PMID><DateCreated><Year>2015</Year><Month>5</Month><Day>2</Day></DateCreated><DateCompleted><Year>2015</Year><Month>07</Month><Day>28</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1938-3207</ISSN><JournalIssue CitedMedium="Internet"><Volume>101</Volume><Issue>5</Issue><PubDate><Year>2015</Year><Month>May</Month></PubDate></JournalIssue><Title>The American journal of clinical nutrition</Title><ISOAbbreviation>Am. J. Clin. Nutr.</ISOAbbreviation></Journal><ArticleTitle>Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease.</ArticleTitle><Pagination><MedlinePgn>931-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3945/ajcn.114.104364</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Epidemiologic data suggest inverse associations between citrus flavanone intake and cardiovascular disease (CVD) risk. However, insufficient randomized controlled trial data limit our understanding of the mechanisms by which flavanones and their metabolites potentially reduce cardiovascular risk factors.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We examined the effects of orange juice or a dose-matched hesperidin supplement on plasma concentrations of established and novel flavanone metabolites and their effects on cardiovascular risk biomarkers in men at moderate CVD risk.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">In an acute, randomized, placebo-controlled crossover trial, 16 fasted participants (aged 51-69 y) received orange juice or a hesperidin supplement (both providing 320 mg hesperidin) or control (all matched for sugar and vitamin C content). At baseline and 5 h postintake, endothelial function (primary outcome), blood pressure, arterial stiffness, cardiac autonomic function, platelet activation, and NADPH oxidase gene expression and plasma flavanone metabolites were assessed. Before each intervention, a diet low in flavonoids, nitrate/nitrite, alcohol, and caffeine was followed, and a standardized low-flavonoid evening meal was consumed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Orange juice intake significantly elevated mean ± SEM plasma concentrations of 8 flavanone (1.75 ± 0.35 μmol/L, P < 0.0001) and 15 phenolic (13.27 ± 2.22 μmol/L, P < 0.0001) metabolites compared with control at 5 h postconsumption. Despite increased plasma flavanone and phenolic metabolite concentrations, cardiovascular risk biomarkers were unaltered. After hesperidin supplement intake, flavanone metabolites were not different from the control, suggesting altered absorption/metabolism compared with the orange juice matrix.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">After single-dose flavanone intake within orange juice, circulating flavanone and phenolic metabolites collectively reached a concentration of 15.20 ± 2.15 μmol/L, but no effects were observed on cardiovascular risk biomarkers. Longer-duration randomized controlled trials are required to examine previous associations between higher flavanone intakes and improved cardiovascular health and to ascertain the relative importance of food matrix and flavanone-derived phenolic metabolites. This trial was registered at clinicaltrials.gov as NCT01530893.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schär</LastName><ForeName>Manuel Y</ForeName><Initials>MY</Initials><AffiliationInfo><Affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Curtis</LastName><ForeName>Peter J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hazim</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ostertag</LastName><ForeName>Luisa M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kay</LastName><ForeName>Colin D</ForeName><Initials>CD</Initials><AffiliationInfo><Affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Potter</LastName><ForeName>John F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cassidy</LastName><ForeName>Aedín</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT01530893</AccessionNumber></AccessionNumberList></DataBank></DataBankList><GrantList CompleteYN="Y"><Grant><GrantID>BB/I006028/1</GrantID><Agency>Biotechnology and Biological Sciences Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>BB/J004545/1</GrantID><Agency>Biotechnology and Biological Sciences Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>Mar</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Clin Nutr</MedlineTA><NlmUniqueID>0376027</NlmUniqueID><ISSNLinking>0002-9165</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010636">Phenols</NameOfSubstance></Chemical><Chemical><RegistryNumber>E750O06Y6O</RegistryNumber><NameOfSubstance UI="D006569">Hesperidin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Physiol. 2000 May 15;525 Pt 1:263-70</RefSource><PMID Version="1">10811742</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nutrients. 2014 Dec;6(12):5772-85</RefSource><PMID 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Supplements</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006569" MajorTopicYN="N">Hesperidin</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010636" MajorTopicYN="N">Phenols</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4409690</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">flavanones</Keyword><Keyword MajorTopicYN="N">flavonoids</Keyword><Keyword MajorTopicYN="N">phenolic metabolites</Keyword><Keyword MajorTopicYN="N">randomized controlled trial</Keyword><Keyword MajorTopicYN="N">vascular function</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>12</Month><Day>7</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>2</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>3</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>3</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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