Phellodendron and Citrus extracts benefit cardiovascular health in osteoarthritis patients: a double-blind, placebo-controlled pilot study.
Identifieur interne : 000990 ( PubMed/Checkpoint ); précédent : 000989; suivant : 000991Phellodendron and Citrus extracts benefit cardiovascular health in osteoarthritis patients: a double-blind, placebo-controlled pilot study.
Auteurs : Julius Oben [Cameroun] ; Ebangha Enonchong ; Shil Kothari ; Walter Chambliss ; Robert Garrison ; Deanne DolnickSource :
- Nutrition journal [ 1475-2891 ] ; 2008.
English descriptors
- KwdEn :
- Adult, Analysis of Variance, Blood Glucose (drug effects), Blood Pressure (drug effects), Body Mass Index, Cardiovascular Diseases (blood), Cardiovascular Diseases (prevention & control), Citrus (chemistry), Dietary Supplements, Double-Blind Method, Female, Humans, Lipid Metabolism (drug effects), Male, Middle Aged, Osteoarthritis (blood), Overweight, Phellodendron (chemistry), Pilot Projects, Plant Extracts (pharmacology), Treatment Outcome, Weight Loss (drug effects), Weight Loss (physiology).
- MESH :
- chemical , drug effects : Blood Glucose.
- blood : Cardiovascular Diseases, Osteoarthritis.
- chemistry : Citrus, Phellodendron.
- drug effects : Blood Pressure, Lipid Metabolism, Weight Loss.
- chemical , pharmacology : Plant Extracts.
- physiology : Weight Loss.
- prevention & control : Cardiovascular Diseases.
- Adult, Analysis of Variance, Body Mass Index, Dietary Supplements, Double-Blind Method, Female, Humans, Male, Middle Aged, Overweight, Pilot Projects, Treatment Outcome.
Abstract
The objective of this clinical study was to assess the potential benefit of a dietary supplement, NP 06-1, on cardiovascular protective properties in overweight and normal weight adults diagnosed with osteoarthritis of the knee.
DOI: 10.1186/1475-2891-7-16
PubMed: 18492265
Affiliations:
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pubmed:18492265Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Phellodendron and Citrus extracts benefit cardiovascular health in osteoarthritis patients: a double-blind, placebo-controlled pilot study.</title><author><name sortKey="Oben, Julius" sort="Oben, Julius" uniqKey="Oben J" first="Julius" last="Oben">Julius Oben</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Nutrition & Nutritional Biochemistry, Department of Biochemistry, University of Yaounde I, Cameroon. juliusoben@hotmail.com</nlm:affiliation><country xml:lang="fr">Cameroun</country><wicri:regionArea>Laboratory of Nutrition & Nutritional Biochemistry, Department of Biochemistry, University of Yaounde I</wicri:regionArea><wicri:noRegion>University of Yaounde I</wicri:noRegion></affiliation></author><author><name sortKey="Enonchong, Ebangha" sort="Enonchong, Ebangha" uniqKey="Enonchong E" first="Ebangha" last="Enonchong">Ebangha Enonchong</name></author><author><name sortKey="Kothari, Shil" sort="Kothari, Shil" uniqKey="Kothari S" first="Shil" last="Kothari">Shil Kothari</name></author><author><name sortKey="Chambliss, Walter" sort="Chambliss, Walter" uniqKey="Chambliss W" first="Walter" last="Chambliss">Walter Chambliss</name></author><author><name sortKey="Garrison, Robert" sort="Garrison, Robert" uniqKey="Garrison R" first="Robert" last="Garrison">Robert Garrison</name></author><author><name sortKey="Dolnick, Deanne" sort="Dolnick, Deanne" uniqKey="Dolnick D" first="Deanne" last="Dolnick">Deanne Dolnick</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18492265</idno><idno type="pmid">18492265</idno><idno type="doi">10.1186/1475-2891-7-16</idno><idno type="wicri:Area/PubMed/Corpus">000A58</idno><idno type="wicri:Area/PubMed/Curation">000A58</idno><idno type="wicri:Area/PubMed/Checkpoint">000A58</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Phellodendron and Citrus extracts benefit cardiovascular health in osteoarthritis patients: a double-blind, placebo-controlled pilot study.</title><author><name sortKey="Oben, Julius" sort="Oben, Julius" uniqKey="Oben J" first="Julius" last="Oben">Julius Oben</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Nutrition & Nutritional Biochemistry, Department of Biochemistry, University of Yaounde I, Cameroon. juliusoben@hotmail.com</nlm:affiliation><country xml:lang="fr">Cameroun</country><wicri:regionArea>Laboratory of Nutrition & Nutritional Biochemistry, Department of Biochemistry, University of Yaounde I</wicri:regionArea><wicri:noRegion>University of Yaounde I</wicri:noRegion></affiliation></author><author><name sortKey="Enonchong, Ebangha" sort="Enonchong, Ebangha" uniqKey="Enonchong E" first="Ebangha" last="Enonchong">Ebangha Enonchong</name></author><author><name sortKey="Kothari, Shil" sort="Kothari, Shil" uniqKey="Kothari S" first="Shil" last="Kothari">Shil Kothari</name></author><author><name sortKey="Chambliss, Walter" sort="Chambliss, Walter" uniqKey="Chambliss W" first="Walter" last="Chambliss">Walter Chambliss</name></author><author><name sortKey="Garrison, Robert" sort="Garrison, Robert" uniqKey="Garrison R" first="Robert" last="Garrison">Robert Garrison</name></author><author><name sortKey="Dolnick, Deanne" sort="Dolnick, Deanne" uniqKey="Dolnick D" first="Deanne" last="Dolnick">Deanne Dolnick</name></author></analytic><series><title level="j">Nutrition journal</title><idno type="eISSN">1475-2891</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Blood Glucose (drug effects)</term><term>Blood Pressure (drug effects)</term><term>Body Mass Index</term><term>Cardiovascular Diseases (blood)</term><term>Cardiovascular Diseases (prevention & control)</term><term>Citrus (chemistry)</term><term>Dietary Supplements</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Lipid Metabolism (drug effects)</term><term>Male</term><term>Middle Aged</term><term>Osteoarthritis (blood)</term><term>Overweight</term><term>Phellodendron (chemistry)</term><term>Pilot Projects</term><term>Plant Extracts (pharmacology)</term><term>Treatment Outcome</term><term>Weight Loss (drug effects)</term><term>Weight Loss (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Blood Glucose</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Cardiovascular Diseases</term><term>Osteoarthritis</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus</term><term>Phellodendron</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blood Pressure</term><term>Lipid Metabolism</term><term>Weight Loss</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Weight Loss</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Cardiovascular Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Body Mass Index</term><term>Dietary Supplements</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Overweight</term><term>Pilot Projects</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this clinical study was to assess the potential benefit of a dietary supplement, NP 06-1, on cardiovascular protective properties in overweight and normal weight adults diagnosed with osteoarthritis of the knee.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18492265</PMID><DateCreated><Year>2008</Year><Month>6</Month><Day>4</Day></DateCreated><DateCompleted><Year>2008</Year><Month>07</Month><Day>10</Day></DateCompleted><DateRevised><Year>2014</Year><Month>9</Month><Day>3</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1475-2891</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><PubDate><Year>2008</Year><Month>May</Month><Day>20</Day></PubDate></JournalIssue><Title>Nutrition journal</Title><ISOAbbreviation>Nutr J</ISOAbbreviation></Journal><ArticleTitle>Phellodendron and Citrus extracts benefit cardiovascular health in osteoarthritis patients: a double-blind, placebo-controlled pilot study.</ArticleTitle><Pagination><MedlinePgn>16</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/1475-2891-7-16</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The objective of this clinical study was to assess the potential benefit of a dietary supplement, NP 06-1, on cardiovascular protective properties in overweight and normal weight adults diagnosed with osteoarthritis of the knee.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">An 8-week, placebo-controlled, randomized, double-blind study was conducted with four groups, comparing the effects of NP 06-1 to placebo in overweight and normal weight subjects diagnosed with primary osteoarthritis of the knee. NP 06-1 (a combination of two botanical extracts; Phellodendron amurense bark and Citrus sinensis peel) or matching placebo was given in a dose of two capsules (370 mg each) twice daily. The outcome measures reported are lipid levels, weight, BMI, blood pressure and fasting glucose. Analyses of variance were used to compare changes of physiological measures over the trial period and between groups.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Eighty (80) subjects were enrolled and 45 subjects completed the study. No serious adverse events were reported. NP 06-1 administration was associated with a general improvement in lipid levels. Both the overweight and normal weight treatment groups had significant reductions in triglycerides and LDL-cholesterol, as well as a significant increase in HDL-cholesterol compared to their respective control groups. Overall there were decreases in blood pressure in both overweight and normal weight treatment groups compared to respective placebo groups. There was also a significant decrease in fasting glucose levels in the overweight treatment group compared to the start of the study and to the overweight placebo group. There was no change in fasting blood sugar for the normal weight groups. Both overweight and normal weight treatment groups lost a significant amount of weight compared to their respective placebo groups. The overweight treatment group lost an average of 5% body weight after 8 weeks, which was associated with a significant loss in BMI over time.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In this pilot study NP 06-1 had a beneficial effect on cardiovascular risk factors; namely lipid levels, blood pressure and fasting glucose levels. Administration of NP 06-1 was also associated with weight loss.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Oben</LastName><ForeName>Julius</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Laboratory of Nutrition & Nutritional Biochemistry, Department of Biochemistry, University of Yaounde I, Cameroon. juliusoben@hotmail.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Enonchong</LastName><ForeName>Ebangha</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Kothari</LastName><ForeName>Shil</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Chambliss</LastName><ForeName>Walter</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Garrison</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Dolnick</LastName><ForeName>Deanne</ForeName><Initials>D</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2008</Year><Month>May</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nutr J</MedlineTA><NlmUniqueID>101152213</NlmUniqueID><ISSNLinking>1475-2891</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001786">Blood Glucose</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Am Acad Nurse Pract. 2004 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Version="1">18220660</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Rheumatology (Oxford). 2001 Jul;40(7):779-93</RefSource><PMID Version="1">11477283</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lipids. 2004 Feb;39(2):143-51</RefSource><PMID Version="1">15134141</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2004 Dec;10(12):1344-51</RefSource><PMID Version="1">15531889</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001786" MajorTopicYN="N">Blood Glucose</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001794" MajorTopicYN="N">Blood Pressure</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015992" MajorTopicYN="N">Body Mass Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002318" MajorTopicYN="N">Cardiovascular Diseases</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002957" MajorTopicYN="N">Citrus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019587" MajorTopicYN="N">Dietary Supplements</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D050356" MajorTopicYN="N">Lipid Metabolism</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010003" MajorTopicYN="N">Osteoarthritis</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050177" MajorTopicYN="N">Overweight</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032102" MajorTopicYN="N">Phellodendron</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010865" MajorTopicYN="N">Pilot Projects</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015431" MajorTopicYN="Y">Weight Loss</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC2409365</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2007</Year><Month>10</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2008</Year><Month>5</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>5</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>7</Month><Day>11</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>5</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18492265</ArticleId><ArticleId IdType="pii">1475-2891-7-16</ArticleId><ArticleId IdType="doi">10.1186/1475-2891-7-16</ArticleId><ArticleId IdType="pmc">PMC2409365</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Cameroun</li></country></list><tree><noCountry><name sortKey="Chambliss, Walter" sort="Chambliss, Walter" uniqKey="Chambliss W" first="Walter" last="Chambliss">Walter Chambliss</name><name sortKey="Dolnick, Deanne" sort="Dolnick, Deanne" uniqKey="Dolnick D" first="Deanne" last="Dolnick">Deanne Dolnick</name><name sortKey="Enonchong, Ebangha" sort="Enonchong, Ebangha" uniqKey="Enonchong E" first="Ebangha" last="Enonchong">Ebangha Enonchong</name><name sortKey="Garrison, Robert" sort="Garrison, Robert" uniqKey="Garrison R" first="Robert" last="Garrison">Robert Garrison</name><name sortKey="Kothari, Shil" sort="Kothari, Shil" uniqKey="Kothari S" first="Shil" last="Kothari">Shil Kothari</name></noCountry><country name="Cameroun"><noRegion><name sortKey="Oben, Julius" sort="Oben, Julius" uniqKey="Oben J" first="Julius" last="Oben">Julius Oben</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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