Phellodendron and Citrus extracts benefit cardiovascular health in osteoarthritis patients: a double-blind, placebo-controlled pilot study.
Identifieur interne : 000990 ( PubMed/Checkpoint ); précédent : 000989; suivant : 000991Phellodendron and Citrus extracts benefit cardiovascular health in osteoarthritis patients: a double-blind, placebo-controlled pilot study.
Auteurs : Julius Oben [Cameroun] ; Ebangha Enonchong ; Shil Kothari ; Walter Chambliss ; Robert Garrison ; Deanne DolnickSource :
- Nutrition journal [ 1475-2891 ] ; 2008.
English descriptors
- KwdEn :
- Adult, Analysis of Variance, Blood Glucose (drug effects), Blood Pressure (drug effects), Body Mass Index, Cardiovascular Diseases (blood), Cardiovascular Diseases (prevention & control), Citrus (chemistry), Dietary Supplements, Double-Blind Method, Female, Humans, Lipid Metabolism (drug effects), Male, Middle Aged, Osteoarthritis (blood), Overweight, Phellodendron (chemistry), Pilot Projects, Plant Extracts (pharmacology), Treatment Outcome, Weight Loss (drug effects), Weight Loss (physiology).
- MESH :
- chemical , drug effects : Blood Glucose.
- blood : Cardiovascular Diseases, Osteoarthritis.
- chemistry : Citrus, Phellodendron.
- drug effects : Blood Pressure, Lipid Metabolism, Weight Loss.
- chemical , pharmacology : Plant Extracts.
- physiology : Weight Loss.
- prevention & control : Cardiovascular Diseases.
- Adult, Analysis of Variance, Body Mass Index, Dietary Supplements, Double-Blind Method, Female, Humans, Male, Middle Aged, Overweight, Pilot Projects, Treatment Outcome.
Abstract
The objective of this clinical study was to assess the potential benefit of a dietary supplement, NP 06-1, on cardiovascular protective properties in overweight and normal weight adults diagnosed with osteoarthritis of the knee.
DOI: 10.1186/1475-2891-7-16
PubMed: 18492265
Affiliations:
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pubmed:18492265Le document en format XML
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<author><name sortKey="Oben, Julius" sort="Oben, Julius" uniqKey="Oben J" first="Julius" last="Oben">Julius Oben</name>
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<wicri:regionArea>Laboratory of Nutrition & Nutritional Biochemistry, Department of Biochemistry, University of Yaounde I</wicri:regionArea>
<wicri:noRegion>University of Yaounde I</wicri:noRegion>
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<author><name sortKey="Enonchong, Ebangha" sort="Enonchong, Ebangha" uniqKey="Enonchong E" first="Ebangha" last="Enonchong">Ebangha Enonchong</name>
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<author><name sortKey="Kothari, Shil" sort="Kothari, Shil" uniqKey="Kothari S" first="Shil" last="Kothari">Shil Kothari</name>
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<author><name sortKey="Garrison, Robert" sort="Garrison, Robert" uniqKey="Garrison R" first="Robert" last="Garrison">Robert Garrison</name>
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<author><name sortKey="Dolnick, Deanne" sort="Dolnick, Deanne" uniqKey="Dolnick D" first="Deanne" last="Dolnick">Deanne Dolnick</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Phellodendron and Citrus extracts benefit cardiovascular health in osteoarthritis patients: a double-blind, placebo-controlled pilot study.</title>
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<author><name sortKey="Enonchong, Ebangha" sort="Enonchong, Ebangha" uniqKey="Enonchong E" first="Ebangha" last="Enonchong">Ebangha Enonchong</name>
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<series><title level="j">Nutrition journal</title>
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<term>Blood Pressure (drug effects)</term>
<term>Body Mass Index</term>
<term>Cardiovascular Diseases (blood)</term>
<term>Cardiovascular Diseases (prevention & control)</term>
<term>Citrus (chemistry)</term>
<term>Dietary Supplements</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Lipid Metabolism (drug effects)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Osteoarthritis (blood)</term>
<term>Overweight</term>
<term>Phellodendron (chemistry)</term>
<term>Pilot Projects</term>
<term>Plant Extracts (pharmacology)</term>
<term>Treatment Outcome</term>
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<term>Weight Loss (physiology)</term>
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<keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Blood Glucose</term>
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<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Cardiovascular Diseases</term>
<term>Osteoarthritis</term>
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<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus</term>
<term>Phellodendron</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blood Pressure</term>
<term>Lipid Metabolism</term>
<term>Weight Loss</term>
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<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Overweight</term>
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<front><div type="abstract" xml:lang="en">The objective of this clinical study was to assess the potential benefit of a dietary supplement, NP 06-1, on cardiovascular protective properties in overweight and normal weight adults diagnosed with osteoarthritis of the knee.</div>
</front>
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<DateCreated><Year>2008</Year>
<Month>6</Month>
<Day>4</Day>
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<DateCompleted><Year>2008</Year>
<Month>07</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2014</Year>
<Month>9</Month>
<Day>3</Day>
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<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1475-2891</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>7</Volume>
<PubDate><Year>2008</Year>
<Month>May</Month>
<Day>20</Day>
</PubDate>
</JournalIssue>
<Title>Nutrition journal</Title>
<ISOAbbreviation>Nutr J</ISOAbbreviation>
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<ArticleTitle>Phellodendron and Citrus extracts benefit cardiovascular health in osteoarthritis patients: a double-blind, placebo-controlled pilot study.</ArticleTitle>
<Pagination><MedlinePgn>16</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.1186/1475-2891-7-16</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The objective of this clinical study was to assess the potential benefit of a dietary supplement, NP 06-1, on cardiovascular protective properties in overweight and normal weight adults diagnosed with osteoarthritis of the knee.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">An 8-week, placebo-controlled, randomized, double-blind study was conducted with four groups, comparing the effects of NP 06-1 to placebo in overweight and normal weight subjects diagnosed with primary osteoarthritis of the knee. NP 06-1 (a combination of two botanical extracts; Phellodendron amurense bark and Citrus sinensis peel) or matching placebo was given in a dose of two capsules (370 mg each) twice daily. The outcome measures reported are lipid levels, weight, BMI, blood pressure and fasting glucose. Analyses of variance were used to compare changes of physiological measures over the trial period and between groups.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Eighty (80) subjects were enrolled and 45 subjects completed the study. No serious adverse events were reported. NP 06-1 administration was associated with a general improvement in lipid levels. Both the overweight and normal weight treatment groups had significant reductions in triglycerides and LDL-cholesterol, as well as a significant increase in HDL-cholesterol compared to their respective control groups. Overall there were decreases in blood pressure in both overweight and normal weight treatment groups compared to respective placebo groups. There was also a significant decrease in fasting glucose levels in the overweight treatment group compared to the start of the study and to the overweight placebo group. There was no change in fasting blood sugar for the normal weight groups. Both overweight and normal weight treatment groups lost a significant amount of weight compared to their respective placebo groups. The overweight treatment group lost an average of 5% body weight after 8 weeks, which was associated with a significant loss in BMI over time.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In this pilot study NP 06-1 had a beneficial effect on cardiovascular risk factors; namely lipid levels, blood pressure and fasting glucose levels. Administration of NP 06-1 was also associated with weight loss.</AbstractText>
</Abstract>
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<ForeName>Julius</ForeName>
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<AffiliationInfo><Affiliation>Laboratory of Nutrition & Nutritional Biochemistry, Department of Biochemistry, University of Yaounde I, Cameroon. juliusoben@hotmail.com</Affiliation>
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