Antioxidant activity, inhibition of nitric oxide overproduction, and in vitro antiproliferative effect of maple sap and syrup from Acer saccharum.
Identifieur interne : 000860 ( PubMed/Checkpoint ); précédent : 000859; suivant : 000861Antioxidant activity, inhibition of nitric oxide overproduction, and in vitro antiproliferative effect of maple sap and syrup from Acer saccharum.
Auteurs : Jean Legault [Canada] ; Karl Girard-Lalancette ; Carole Grenon ; Catherine Dussault ; André PichetteSource :
- Journal of medicinal food [ 1557-7600 ] ; 2010.
English descriptors
- KwdEn :
- Acer, Animals, Antineoplastic Agents, Phytogenic (pharmacology), Antineoplastic Agents, Phytogenic (therapeutic use), Antioxidants (pharmacology), Antioxidants (therapeutic use), Blueberry Plant, Cell Line, Cell Line, Tumor, Cell Proliferation (drug effects), Citrus sinensis, Fibroblasts (drug effects), Fibroblasts (metabolism), Fragaria, Humans, Lipopolysaccharides, Macrophages (drug effects), Macrophages (metabolism), Mice, Neoplasms (drug therapy), Nitric Oxide (biosynthesis), Phytotherapy, Plant Extracts (pharmacology), Plant Extracts (therapeutic use), Plant Exudates, Reactive Oxygen Species (metabolism).
- MESH :
- chemical , biosynthesis : Nitric Oxide.
- chemical , metabolism : Reactive Oxygen Species.
- chemical , pharmacology : Antineoplastic Agents, Phytogenic, Antioxidants, Plant Extracts.
- chemical , therapeutic use : Antineoplastic Agents, Phytogenic, Antioxidants, Plant Extracts.
- drug effects : Cell Proliferation, Fibroblasts, Macrophages.
- drug therapy : Neoplasms.
- metabolism : Fibroblasts, Macrophages.
- Acer, Animals, Blueberry Plant, Cell Line, Cell Line, Tumor, Citrus sinensis, Fragaria, Humans, Lipopolysaccharides, Mice, Phytotherapy, Plant Exudates.
Abstract
Antioxidant activity, inhibition of nitric oxide (NO) overproduction, and antiproliferative effect of ethyl acetate extracts of maple sap and syrup from 30 producers were evaluated in regard to the period of harvest in three different regions of Québec, Canada. Oxygen radical absorbance capacity (ORAC) values of maple sap and syrup extracts are, respectively, 12 +/- 6 and 15 +/- 5 micromol of Trolox equivalents (TE)/mg. The antioxidant activity was also confirmed by a cell-based assay. The period of harvest has no statistically significant incidence on the antioxidant activity of both extracts. The antioxidant activity of pure maple syrup was also determined using the ORAC assay. Results indicate that the ORAC value of pure maple syrup (8 +/- 2 micromol of TE/mL) is lower than the ORAC value of blueberry juice (24 +/- 1 micromol of TE/mL) but comparable to the ORAC values of strawberry (10.7 +/- 0.4 micromol of TE/mL) and orange (10.8 +/- 0.5 micromol of TE/mL) juices. Maple sap and syrup extracts showed to significantly inhibit lipopolysaccharide-induced NO overproduction in RAW264.7 murine macrophages. Maple syrup extract was significantly more active than maple sap extract, suggesting that the transformation of maple sap into syrup increases NO inhibition activity. The highest NO inhibition induced by the maple syrup extracts was observed at the end of the season. Moreover, darker maple syrup was found to be more active than clear maple syrup, suggesting that some colored oxidized compounds could be responsible in part for the activity. Finally, maple syrup extracts (50% inhibitory concentration = 42 +/- 6 microg/mL) and pure maple syrup possess a selective in vitro antiproliferative activity against cancer cells.
DOI: 10.1089/jmf.2009.0029
PubMed: 20132041
Affiliations:
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last="Girard-Lalancette">Karl Girard-Lalancette</name></author><author><name sortKey="Grenon, Carole" sort="Grenon, Carole" uniqKey="Grenon C" first="Carole" last="Grenon">Carole Grenon</name></author><author><name sortKey="Dussault, Catherine" sort="Dussault, Catherine" uniqKey="Dussault C" first="Catherine" last="Dussault">Catherine Dussault</name></author><author><name sortKey="Pichette, Andre" sort="Pichette, Andre" uniqKey="Pichette A" first="André" last="Pichette">André Pichette</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20132041</idno><idno type="pmid">20132041</idno><idno type="doi">10.1089/jmf.2009.0029</idno><idno type="wicri:Area/PubMed/Corpus">000863</idno><idno type="wicri:Area/PubMed/Curation">000863</idno><idno type="wicri:Area/PubMed/Checkpoint">000863</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antioxidant activity, inhibition of nitric oxide 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uniqKey="Grenon C" first="Carole" last="Grenon">Carole Grenon</name></author><author><name sortKey="Dussault, Catherine" sort="Dussault, Catherine" uniqKey="Dussault C" first="Catherine" last="Dussault">Catherine Dussault</name></author><author><name sortKey="Pichette, Andre" sort="Pichette, Andre" uniqKey="Pichette A" first="André" last="Pichette">André Pichette</name></author></analytic><series><title level="j">Journal of medicinal food</title><idno type="eISSN">1557-7600</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acer</term><term>Animals</term><term>Antineoplastic Agents, Phytogenic (pharmacology)</term><term>Antineoplastic Agents, Phytogenic (therapeutic use)</term><term>Antioxidants (pharmacology)</term><term>Antioxidants (therapeutic use)</term><term>Blueberry Plant</term><term>Cell Line</term><term>Cell Line, Tumor</term><term>Cell Proliferation (drug effects)</term><term>Citrus sinensis</term><term>Fibroblasts (drug effects)</term><term>Fibroblasts (metabolism)</term><term>Fragaria</term><term>Humans</term><term>Lipopolysaccharides</term><term>Macrophages (drug effects)</term><term>Macrophages (metabolism)</term><term>Mice</term><term>Neoplasms (drug therapy)</term><term>Nitric Oxide (biosynthesis)</term><term>Phytotherapy</term><term>Plant Extracts (pharmacology)</term><term>Plant Extracts (therapeutic use)</term><term>Plant Exudates</term><term>Reactive Oxygen Species (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Nitric Oxide</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents, Phytogenic</term><term>Antioxidants</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Agents, Phytogenic</term><term>Antioxidants</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term><term>Fibroblasts</term><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Fibroblasts</term><term>Macrophages</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acer</term><term>Animals</term><term>Blueberry Plant</term><term>Cell Line</term><term>Cell Line, Tumor</term><term>Citrus sinensis</term><term>Fragaria</term><term>Humans</term><term>Lipopolysaccharides</term><term>Mice</term><term>Phytotherapy</term><term>Plant Exudates</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Antioxidant activity, inhibition of nitric oxide (NO) overproduction, and antiproliferative effect of ethyl acetate extracts of maple sap and syrup from 30 producers were evaluated in regard to the period of harvest in three different regions of Québec, Canada. Oxygen radical absorbance capacity (ORAC) values of maple sap and syrup extracts are, respectively, 12 +/- 6 and 15 +/- 5 micromol of Trolox equivalents (TE)/mg. The antioxidant activity was also confirmed by a cell-based assay. The period of harvest has no statistically significant incidence on the antioxidant activity of both extracts. The antioxidant activity of pure maple syrup was also determined using the ORAC assay. Results indicate that the ORAC value of pure maple syrup (8 +/- 2 micromol of TE/mL) is lower than the ORAC value of blueberry juice (24 +/- 1 micromol of TE/mL) but comparable to the ORAC values of strawberry (10.7 +/- 0.4 micromol of TE/mL) and orange (10.8 +/- 0.5 micromol of TE/mL) juices. Maple sap and syrup extracts showed to significantly inhibit lipopolysaccharide-induced NO overproduction in RAW264.7 murine macrophages. Maple syrup extract was significantly more active than maple sap extract, suggesting that the transformation of maple sap into syrup increases NO inhibition activity. The highest NO inhibition induced by the maple syrup extracts was observed at the end of the season. Moreover, darker maple syrup was found to be more active than clear maple syrup, suggesting that some colored oxidized compounds could be responsible in part for the activity. Finally, maple syrup extracts (50% inhibitory concentration = 42 +/- 6 microg/mL) and pure maple syrup possess a selective in vitro antiproliferative activity against cancer cells.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20132041</PMID><DateCreated><Year>2010</Year><Month>4</Month><Day>23</Day></DateCreated><DateCompleted><Year>2010</Year><Month>10</Month><Day>21</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1557-7600</ISSN><JournalIssue CitedMedium="Internet"><Volume>13</Volume><Issue>2</Issue><PubDate><Year>2010</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Journal of medicinal food</Title><ISOAbbreviation>J Med Food</ISOAbbreviation></Journal><ArticleTitle>Antioxidant activity, inhibition of nitric oxide overproduction, and in vitro antiproliferative effect of maple sap and syrup from Acer saccharum.</ArticleTitle><Pagination><MedlinePgn>460-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1089/jmf.2009.0029</ELocationID><Abstract><AbstractText>Antioxidant activity, inhibition of nitric oxide (NO) overproduction, and antiproliferative effect of ethyl acetate extracts of maple sap and syrup from 30 producers were evaluated in regard to the period of harvest in three different regions of Québec, Canada. Oxygen radical absorbance capacity (ORAC) values of maple sap and syrup extracts are, respectively, 12 +/- 6 and 15 +/- 5 micromol of Trolox equivalents (TE)/mg. The antioxidant activity was also confirmed by a cell-based assay. The period of harvest has no statistically significant incidence on the antioxidant activity of both extracts. The antioxidant activity of pure maple syrup was also determined using the ORAC assay. Results indicate that the ORAC value of pure maple syrup (8 +/- 2 micromol of TE/mL) is lower than the ORAC value of blueberry juice (24 +/- 1 micromol of TE/mL) but comparable to the ORAC values of strawberry (10.7 +/- 0.4 micromol of TE/mL) and orange (10.8 +/- 0.5 micromol of TE/mL) juices. Maple sap and syrup extracts showed to significantly inhibit lipopolysaccharide-induced NO overproduction in RAW264.7 murine macrophages. Maple syrup extract was significantly more active than maple sap extract, suggesting that the transformation of maple sap into syrup increases NO inhibition activity. The highest NO inhibition induced by the maple syrup extracts was observed at the end of the season. Moreover, darker maple syrup was found to be more active than clear maple syrup, suggesting that some colored oxidized compounds could be responsible in part for the activity. Finally, maple syrup extracts (50% inhibitory concentration = 42 +/- 6 microg/mL) and pure maple syrup possess a selective in vitro antiproliferative activity against cancer cells.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Legault</LastName><ForeName>Jean</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Québec, Canada. jean_legault@uqac.ca</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Girard-Lalancette</LastName><ForeName>Karl</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Grenon</LastName><ForeName>Carole</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Dussault</LastName><ForeName>Catherine</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Pichette</LastName><ForeName>André</ForeName><Initials>A</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Med Food</MedlineTA><NlmUniqueID>9812512</NlmUniqueID><ISSNLinking>1096-620X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000972">Antineoplastic Agents, Phytogenic</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008070">Lipopolysaccharides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant 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PubStatus="pubmed"><Year>2010</Year><Month>2</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>10</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20132041</ArticleId><ArticleId IdType="doi">10.1089/jmf.2009.0029</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Dussault, Catherine" sort="Dussault, Catherine" uniqKey="Dussault C" first="Catherine" last="Dussault">Catherine Dussault</name><name sortKey="Girard Lalancette, Karl" sort="Girard Lalancette, Karl" uniqKey="Girard Lalancette K" first="Karl" last="Girard-Lalancette">Karl Girard-Lalancette</name><name sortKey="Grenon, Carole" sort="Grenon, Carole" uniqKey="Grenon C" first="Carole" last="Grenon">Carole Grenon</name><name sortKey="Pichette, Andre" sort="Pichette, Andre" uniqKey="Pichette A" first="André" last="Pichette">André Pichette</name></noCountry><country name="Canada"><noRegion><name sortKey="Legault, Jean" sort="Legault, Jean" uniqKey="Legault J" first="Jean" last="Legault">Jean Legault</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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