Antioxidant capacity of hesperidin from citrus peel using electron spin resonance and cytotoxic activity against human carcinoma cell lines.
Identifieur interne : 000755 ( PubMed/Checkpoint ); précédent : 000754; suivant : 000756Antioxidant capacity of hesperidin from citrus peel using electron spin resonance and cytotoxic activity against human carcinoma cell lines.
Auteurs : Hanan A. Al-Ashaal [Égypte] ; Shakinaz T. El-SheltawySource :
- Pharmaceutical biology [ 1744-5116 ] ; 2011.
English descriptors
- KwdEn :
- Antineoplastic Agents, Phytogenic (isolation & purification), Antineoplastic Agents, Phytogenic (pharmacology), Antioxidants (isolation & purification), Antioxidants (pharmacology), Cell Line, Tumor, Citrus sinensis, Cytotoxins (isolation & purification), Cytotoxins (pharmacology), Electron Spin Resonance Spectroscopy (methods), HeLa Cells, Hesperidin (isolation & purification), Hesperidin (pharmacology), Humans, Plant Extracts (isolation & purification), Plant Extracts (pharmacology).
- MESH :
- chemical , isolation & purification : Antineoplastic Agents, Phytogenic, Antioxidants, Cytotoxins, Hesperidin, Plant Extracts.
- chemical , pharmacology : Antineoplastic Agents, Phytogenic, Antioxidants, Cytotoxins, Hesperidin, Plant Extracts.
- methods : Electron Spin Resonance Spectroscopy.
- Cell Line, Tumor, Citrus sinensis, HeLa Cells, Humans.
Abstract
Hesperidin is a flavonoid that has various pharmacological activities including anti-inflammatory, antimicrobial and antiviral activities.
DOI: 10.3109/13880209.2010.509734
PubMed: 21323480
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antioxidant capacity of hesperidin from citrus peel using electron spin resonance and cytotoxic activity against human carcinoma cell lines.</title><author><name sortKey="Al Ashaal, Hanan A" sort="Al Ashaal, Hanan A" uniqKey="Al Ashaal H" first="Hanan A" last="Al-Ashaal">Hanan A. Al-Ashaal</name><affiliation wicri:level="1"><nlm:affiliation>Research of Drugs and Pharmaceutical Industries Division, National Research Center, Dokki, Giza, Egypt. hanan_alashaal@yahoo.com</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Research of Drugs and Pharmaceutical Industries Division, National Research Center, Dokki, Giza</wicri:regionArea><wicri:noRegion>Giza</wicri:noRegion></affiliation></author><author><name sortKey="El Sheltawy, Shakinaz T" sort="El Sheltawy, Shakinaz T" uniqKey="El Sheltawy S" first="Shakinaz T" last="El-Sheltawy">Shakinaz T. El-Sheltawy</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21323480</idno><idno type="pmid">21323480</idno><idno type="doi">10.3109/13880209.2010.509734</idno><idno type="wicri:Area/PubMed/Corpus">000757</idno><idno type="wicri:Area/PubMed/Curation">000757</idno><idno type="wicri:Area/PubMed/Checkpoint">000757</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antioxidant capacity of hesperidin from citrus peel using electron spin resonance and cytotoxic activity against human carcinoma cell lines.</title><author><name sortKey="Al Ashaal, Hanan A" sort="Al Ashaal, Hanan A" uniqKey="Al Ashaal H" first="Hanan A" last="Al-Ashaal">Hanan A. Al-Ashaal</name><affiliation wicri:level="1"><nlm:affiliation>Research of Drugs and Pharmaceutical Industries Division, National Research Center, Dokki, Giza, Egypt. hanan_alashaal@yahoo.com</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Research of Drugs and Pharmaceutical Industries Division, National Research Center, Dokki, Giza</wicri:regionArea><wicri:noRegion>Giza</wicri:noRegion></affiliation></author><author><name sortKey="El Sheltawy, Shakinaz T" sort="El Sheltawy, Shakinaz T" uniqKey="El Sheltawy S" first="Shakinaz T" last="El-Sheltawy">Shakinaz T. El-Sheltawy</name></author></analytic><series><title level="j">Pharmaceutical biology</title><idno type="eISSN">1744-5116</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic Agents, Phytogenic (isolation & purification)</term><term>Antineoplastic Agents, Phytogenic (pharmacology)</term><term>Antioxidants (isolation & purification)</term><term>Antioxidants (pharmacology)</term><term>Cell Line, Tumor</term><term>Citrus sinensis</term><term>Cytotoxins (isolation & purification)</term><term>Cytotoxins (pharmacology)</term><term>Electron Spin Resonance Spectroscopy (methods)</term><term>HeLa Cells</term><term>Hesperidin (isolation & purification)</term><term>Hesperidin (pharmacology)</term><term>Humans</term><term>Plant Extracts (isolation & purification)</term><term>Plant Extracts (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antineoplastic Agents, Phytogenic</term><term>Antioxidants</term><term>Cytotoxins</term><term>Hesperidin</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents, Phytogenic</term><term>Antioxidants</term><term>Cytotoxins</term><term>Hesperidin</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electron Spin Resonance Spectroscopy</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term><term>Citrus sinensis</term><term>HeLa Cells</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hesperidin is a flavonoid that has various pharmacological activities including anti-inflammatory, antimicrobial and antiviral activities.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21323480</PMID><DateCreated><Year>2011</Year><Month>2</Month><Day>17</Day></DateCreated><DateCompleted><Year>2011</Year><Month>12</Month><Day>22</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1744-5116</ISSN><JournalIssue CitedMedium="Internet"><Volume>49</Volume><Issue>3</Issue><PubDate><Year>2011</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Pharmaceutical biology</Title><ISOAbbreviation>Pharm Biol</ISOAbbreviation></Journal><ArticleTitle>Antioxidant capacity of hesperidin from citrus peel using electron spin resonance and cytotoxic activity against human carcinoma cell lines.</ArticleTitle><Pagination><MedlinePgn>276-82</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3109/13880209.2010.509734</ELocationID><Abstract><AbstractText Label="CONTEXT" NlmCategory="BACKGROUND">Hesperidin is a flavonoid that has various pharmacological activities including anti-inflammatory, antimicrobial and antiviral activities.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The aim of the study is the isolation of hesperidin from the peel of Citrus sinensis L. (Rutaceae), and the evaluation of its antioxidant capacity and cytotoxicity against different human carcinoma cell lines.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">In the present work, hesperidin is identified and confirmed using chromatographic and spectral analysis. To correlate between hesperidin concentration and antioxidant capacity of peel extracts, extraction was carried out using 1% HCl-MeOH, MeOH, alkaline solution, the concentration of hesperidin determined qualitatively and quantitatively using high performance thin layer chromatography (HPTLC), high performance liquid chromatography (HPLC) analysis, in vitro antioxidant capacity of hesperidin and the extracts against free radical diphenylpicrylhydrazyl (DPPH•) performed using an electron spin resonance spectrophotometer (ESR). Cytotoxic assay against larynx, cervix, breast and liver carcinoma cell lines was performed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Hesperidin was found to be moderately active as an antioxidant agent; its capacity reached 36%. In addition, the results revealed that hesperidin exhibited pronounced anticancer activity against the selected cell lines. IC₅₀ were 1.67, 3.33, 4.17, 4.58 µg/mL, respectively.</AbstractText><AbstractText Label="DISCUSSION AND CONCLUSION" NlmCategory="CONCLUSIONS">Orange peels are considered to be a cheap source for hesperidin which may be used in the pharmaceutical industry as a natural chemopreventive agent. Hesperidin and orange peel extract could possess antioxidant properties with a wide range of therapeutic applications.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Al-Ashaal</LastName><ForeName>Hanan A</ForeName><Initials>HA</Initials><AffiliationInfo><Affiliation>Research of Drugs and Pharmaceutical Industries Division, National Research Center, Dokki, Giza, Egypt. hanan_alashaal@yahoo.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>El-Sheltawy</LastName><ForeName>Shakinaz T</ForeName><Initials>ST</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Pharm Biol</MedlineTA><NlmUniqueID>9812552</NlmUniqueID><ISSNLinking>1388-0209</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000972">Antineoplastic Agents, Phytogenic</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003603">Cytotoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>E750O06Y6O</RegistryNumber><NameOfSubstance UI="D006569">Hesperidin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000972" MajorTopicYN="N">Antineoplastic Agents, Phytogenic</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="Y">Citrus sinensis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003603" MajorTopicYN="N">Cytotoxins</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004578" MajorTopicYN="N">Electron Spin Resonance Spectroscopy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006367" MajorTopicYN="N">HeLa Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006569" MajorTopicYN="N">Hesperidin</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>2</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>2</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>12</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21323480</ArticleId><ArticleId IdType="doi">10.3109/13880209.2010.509734</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Égypte</li></country></list><tree><noCountry><name sortKey="El Sheltawy, Shakinaz T" sort="El Sheltawy, Shakinaz T" uniqKey="El Sheltawy S" first="Shakinaz T" last="El-Sheltawy">Shakinaz T. El-Sheltawy</name></noCountry><country name="Égypte"><noRegion><name sortKey="Al Ashaal, Hanan A" sort="Al Ashaal, Hanan A" uniqKey="Al Ashaal H" first="Hanan A" last="Al-Ashaal">Hanan A. Al-Ashaal</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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