Effect of orange juice and beverage with phytosterols on cytokines and PAI-1 activity.
Identifieur interne : 000723 ( PubMed/Checkpoint ); précédent : 000722; suivant : 000724Effect of orange juice and beverage with phytosterols on cytokines and PAI-1 activity.
Auteurs : Sridevi Devaraj [États-Unis] ; Ishwarlal Jialal ; Jason Rockwood ; Danielle ZakSource :
- Clinical nutrition (Edinburgh, Scotland) [ 1532-1983 ] ; 2011.
English descriptors
- KwdEn :
- Adult, Aged, Beverages (analysis), Biomarkers (blood), Citrus sinensis (chemistry), Dietary Supplements (analysis), Double-Blind Method, Down-Regulation, Female, Fibrinolysis, Fruit (chemistry), Humans, Interleukin-1beta (blood), Interleukin-6 (blood), Male, Middle Aged, Phytosterols (administration & dosage), Plasminogen Activator Inhibitor 1 (blood), Retrospective Studies, Young Adult.
- MESH :
- chemical , administration & dosage : Phytosterols.
- chemical , blood : Biomarkers, Interleukin-1beta, Interleukin-6, Plasminogen Activator Inhibitor 1.
- analysis : Beverages, Dietary Supplements.
- chemistry : Citrus sinensis, Fruit.
- Adult, Aged, Double-Blind Method, Down-Regulation, Female, Fibrinolysis, Humans, Male, Middle Aged, Retrospective Studies, Young Adult.
Abstract
Inflammation is pivotal in all phases of atherosclerosis. Dietary options which lower inflammatory biomarkers would be an attractive strategy to reduce risk from cardiovascular diseases and cancer. Indeed, fruit and vegetable intake or fruit juice consumption is associated with health and wellness. However, there is a paucity of data examining the effect of orange juice on biomarkers of inflammation in healthy volunteers. We have previously conducted the first placebo-controlled randomized studies examining the effect of sterol fortified orange juice or sterol fortified reduced calorie orange juice beverage supplementation (2 g sterols/day) compared to Placebo OJ or Placebo OJBev, and showed significant benefits on the lipid profile as well as significant reduction in hsCRP, the prototypic marker of inflammation and a cardiovascular risk marker. The aim of this study was to examine the effect of orange juice (OJ) or OJ beverage (Bev) alone and fortified with plant sterols (1g/240 ml juice or beverage twice a day) on pro-inflammatory cytokines and PAI-1, a marker of impaired fibrinolysis in healthy human volunteers.
DOI: 10.1016/j.clnu.2011.03.009
PubMed: 21477901
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:21477901Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of orange juice and beverage with phytosterols on cytokines and PAI-1 activity.</title>
<author><name sortKey="Devaraj, Sridevi" sort="Devaraj, Sridevi" uniqKey="Devaraj S" first="Sridevi" last="Devaraj">Sridevi Devaraj</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA 95817, USA. sdevaraj@ucdavis.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA 95817</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jialal, Ishwarlal" sort="Jialal, Ishwarlal" uniqKey="Jialal I" first="Ishwarlal" last="Jialal">Ishwarlal Jialal</name>
</author>
<author><name sortKey="Rockwood, Jason" sort="Rockwood, Jason" uniqKey="Rockwood J" first="Jason" last="Rockwood">Jason Rockwood</name>
</author>
<author><name sortKey="Zak, Danielle" sort="Zak, Danielle" uniqKey="Zak D" first="Danielle" last="Zak">Danielle Zak</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2011">2011</date>
<idno type="RBID">pubmed:21477901</idno>
<idno type="pmid">21477901</idno>
<idno type="doi">10.1016/j.clnu.2011.03.009</idno>
<idno type="wicri:Area/PubMed/Corpus">000696</idno>
<idno type="wicri:Area/PubMed/Curation">000696</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000696</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of orange juice and beverage with phytosterols on cytokines and PAI-1 activity.</title>
<author><name sortKey="Devaraj, Sridevi" sort="Devaraj, Sridevi" uniqKey="Devaraj S" first="Sridevi" last="Devaraj">Sridevi Devaraj</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA 95817, USA. sdevaraj@ucdavis.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA 95817</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jialal, Ishwarlal" sort="Jialal, Ishwarlal" uniqKey="Jialal I" first="Ishwarlal" last="Jialal">Ishwarlal Jialal</name>
</author>
<author><name sortKey="Rockwood, Jason" sort="Rockwood, Jason" uniqKey="Rockwood J" first="Jason" last="Rockwood">Jason Rockwood</name>
</author>
<author><name sortKey="Zak, Danielle" sort="Zak, Danielle" uniqKey="Zak D" first="Danielle" last="Zak">Danielle Zak</name>
</author>
</analytic>
<series><title level="j">Clinical nutrition (Edinburgh, Scotland)</title>
<idno type="eISSN">1532-1983</idno>
<imprint><date when="2011" type="published">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Beverages (analysis)</term>
<term>Biomarkers (blood)</term>
<term>Citrus sinensis (chemistry)</term>
<term>Dietary Supplements (analysis)</term>
<term>Double-Blind Method</term>
<term>Down-Regulation</term>
<term>Female</term>
<term>Fibrinolysis</term>
<term>Fruit (chemistry)</term>
<term>Humans</term>
<term>Interleukin-1beta (blood)</term>
<term>Interleukin-6 (blood)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Phytosterols (administration & dosage)</term>
<term>Plasminogen Activator Inhibitor 1 (blood)</term>
<term>Retrospective Studies</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Phytosterols</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term>
<term>Interleukin-1beta</term>
<term>Interleukin-6</term>
<term>Plasminogen Activator Inhibitor 1</term>
</keywords>
<keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Beverages</term>
<term>Dietary Supplements</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term>
<term>Fruit</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Double-Blind Method</term>
<term>Down-Regulation</term>
<term>Female</term>
<term>Fibrinolysis</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
<term>Young Adult</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Inflammation is pivotal in all phases of atherosclerosis. Dietary options which lower inflammatory biomarkers would be an attractive strategy to reduce risk from cardiovascular diseases and cancer. Indeed, fruit and vegetable intake or fruit juice consumption is associated with health and wellness. However, there is a paucity of data examining the effect of orange juice on biomarkers of inflammation in healthy volunteers. We have previously conducted the first placebo-controlled randomized studies examining the effect of sterol fortified orange juice or sterol fortified reduced calorie orange juice beverage supplementation (2 g sterols/day) compared to Placebo OJ or Placebo OJBev, and showed significant benefits on the lipid profile as well as significant reduction in hsCRP, the prototypic marker of inflammation and a cardiovascular risk marker. The aim of this study was to examine the effect of orange juice (OJ) or OJ beverage (Bev) alone and fortified with plant sterols (1g/240 ml juice or beverage twice a day) on pro-inflammatory cytokines and PAI-1, a marker of impaired fibrinolysis in healthy human volunteers.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21477901</PMID>
<DateCreated><Year>2011</Year>
<Month>10</Month>
<Day>10</Day>
</DateCreated>
<DateCompleted><Year>2012</Year>
<Month>02</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>11</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-1983</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>30</Volume>
<Issue>5</Issue>
<PubDate><Year>2011</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>Clinical nutrition (Edinburgh, Scotland)</Title>
<ISOAbbreviation>Clin Nutr</ISOAbbreviation>
</Journal>
<ArticleTitle>Effect of orange juice and beverage with phytosterols on cytokines and PAI-1 activity.</ArticleTitle>
<Pagination><MedlinePgn>668-71</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.clnu.2011.03.009</ELocationID>
<Abstract><AbstractText Label="BACKGROUND & AIMS" NlmCategory="OBJECTIVE">Inflammation is pivotal in all phases of atherosclerosis. Dietary options which lower inflammatory biomarkers would be an attractive strategy to reduce risk from cardiovascular diseases and cancer. Indeed, fruit and vegetable intake or fruit juice consumption is associated with health and wellness. However, there is a paucity of data examining the effect of orange juice on biomarkers of inflammation in healthy volunteers. We have previously conducted the first placebo-controlled randomized studies examining the effect of sterol fortified orange juice or sterol fortified reduced calorie orange juice beverage supplementation (2 g sterols/day) compared to Placebo OJ or Placebo OJBev, and showed significant benefits on the lipid profile as well as significant reduction in hsCRP, the prototypic marker of inflammation and a cardiovascular risk marker. The aim of this study was to examine the effect of orange juice (OJ) or OJ beverage (Bev) alone and fortified with plant sterols (1g/240 ml juice or beverage twice a day) on pro-inflammatory cytokines and PAI-1, a marker of impaired fibrinolysis in healthy human volunteers.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">In the first study, 72 healthy human volunteers received Placebo OJ or Sterol OJ and in the second study, 72 volunteers received OJBev or Sterol OJBev for 8 weeks and blood was drawn at baseline and following supplementation for 8 weeks. Biomarkers of Inflammation (IL-1b, IL-6, TNF, IL-8, IL-10) were assessed in serum using the BD Human Inflammatory Cytokine Cytometric Bead Array and PAI-1 activity was assessed in citrated plasma.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">OJ or OJBev alone failed to result in any significant effects on circulating cytokine levels or PAI-1 activity. There was a significant reduction in IL-1b with sterol fortified OJ (p < 0.05) compared to baseline. In addition, both sterol fortified OJ as well as sterol fortified OJBev resulted in significant reductions in serum IL-6 levels (p < 0.01).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Thus, sterol fortified OJ and OJ Beverage are able to effectively lower biomarkers of inflammation in healthy human volunteers in addition to providing lipid profile benefits and may thus contribute to decreasing cardiovascular risk.</AbstractText>
<CopyrightInformation>Copyright © 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Devaraj</LastName>
<ForeName>Sridevi</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA 95817, USA. sdevaraj@ucdavis.edu</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jialal</LastName>
<ForeName>Ishwarlal</ForeName>
<Initials>I</Initials>
</Author>
<Author ValidYN="Y"><LastName>Rockwood</LastName>
<ForeName>Jason</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zak</LastName>
<ForeName>Danielle</ForeName>
<Initials>D</Initials>
</Author>
</AuthorList>
<Language>ENG</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>K24 AT 00596</GrantID>
<Acronym>AT</Acronym>
<Agency>NCCIH NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2011</Year>
<Month>Apr</Month>
<Day>08</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Clin Nutr</MedlineTA>
<NlmUniqueID>8309603</NlmUniqueID>
<ISSNLinking>0261-5614</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C508585">IL1B protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C508600">IL6 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D053583">Interleukin-1beta</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010840">Phytosterols</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017395">Plasminogen Activator Inhibitor 1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C051321">SERPINE1 protein, human</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001628" MajorTopicYN="Y">Beverages</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D032084" MajorTopicYN="N">Citrus sinensis</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019587" MajorTopicYN="Y">Dietary Supplements</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015536" MajorTopicYN="N">Down-Regulation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005342" MajorTopicYN="N">Fibrinolysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005638" MajorTopicYN="N">Fruit</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053583" MajorTopicYN="N">Interleukin-1beta</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010840" MajorTopicYN="N">Phytosterols</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017395" MajorTopicYN="N">Plasminogen Activator Inhibitor 1</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2008</Year>
<Month>9</Month>
<Day>13</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2011</Year>
<Month>3</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2011</Year>
<Month>3</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2011</Year>
<Month>4</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2011</Year>
<Month>4</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2012</Year>
<Month>2</Month>
<Day>24</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">21477901</ArticleId>
<ArticleId IdType="pii">S0261-5614(11)00061-6</ArticleId>
<ArticleId IdType="doi">10.1016/j.clnu.2011.03.009</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Californie</li>
</region>
</list>
<tree><noCountry><name sortKey="Jialal, Ishwarlal" sort="Jialal, Ishwarlal" uniqKey="Jialal I" first="Ishwarlal" last="Jialal">Ishwarlal Jialal</name>
<name sortKey="Rockwood, Jason" sort="Rockwood, Jason" uniqKey="Rockwood J" first="Jason" last="Rockwood">Jason Rockwood</name>
<name sortKey="Zak, Danielle" sort="Zak, Danielle" uniqKey="Zak D" first="Danielle" last="Zak">Danielle Zak</name>
</noCountry>
<country name="États-Unis"><region name="Californie"><name sortKey="Devaraj, Sridevi" sort="Devaraj, Sridevi" uniqKey="Devaraj S" first="Sridevi" last="Devaraj">Sridevi Devaraj</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/OrangerV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000723 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000723 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Bois |area= OrangerV1 |flux= PubMed |étape= Checkpoint |type= RBID |clé= pubmed:21477901 |texte= Effect of orange juice and beverage with phytosterols on cytokines and PAI-1 activity. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:21477901" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a OrangerV1
![]() | This area was generated with Dilib version V0.6.25. | ![]() |