Orange juice and its component, hesperidin, decrease the expression of multidrug resistance-associated protein 2 in rat small intestine and liver.
Identifieur interne : 000686 ( PubMed/Checkpoint ); précédent : 000685; suivant : 000687Orange juice and its component, hesperidin, decrease the expression of multidrug resistance-associated protein 2 in rat small intestine and liver.
Auteurs : Minoru Watanabe [Japon] ; Naoki Matsumoto ; Yuko Takeba ; Toshio Kumai ; Masami Tanaka ; Shinobu Tatsunami ; Sachiko Takenoshita-Nakaya ; Yoshie Harimoto ; Yuichi Kinoshita ; Shinichi KobayashiSource :
- Journal of biomedicine & biotechnology [ 1110-7251 ] ; 2011.
English descriptors
- KwdEn :
- Animals, Area Under Curve, Beverages, Citrus sinensis (chemistry), Drug Administration Schedule, Hesperidin (pharmacology), Intestine, Small (drug effects), Intestine, Small (metabolism), Liver (drug effects), Liver (metabolism), Male, Multidrug Resistance-Associated Proteins (drug effects), Multidrug Resistance-Associated Proteins (metabolism), Plasma (drug effects), Plasma (metabolism), Pravastatin (blood), Pravastatin (pharmacokinetics), RNA, Messenger (drug effects), RNA, Messenger (metabolism), Rats, Rats, Sprague-Dawley.
- MESH :
- chemical , blood : Pravastatin.
- chemical , drug effects : Multidrug Resistance-Associated Proteins, RNA, Messenger.
- chemical , metabolism : Multidrug Resistance-Associated Proteins, RNA, Messenger.
- chemical , pharmacokinetics : Pravastatin.
- chemical , pharmacology : Hesperidin.
- chemistry : Citrus sinensis.
- drug effects : Intestine, Small, Liver, Plasma.
- metabolism : Intestine, Small, Liver, Plasma.
- Animals, Area Under Curve, Beverages, Drug Administration Schedule, Male, Rats, Rats, Sprague-Dawley.
Abstract
We investigated the effects of orange juice (OJ) or hesperidin, a component of OJ, on the pharmacokinetics of pravastatin (PRV) and the expression of both protein and mRNA of multidrug resistance-associated protein 2 (Mrp2) in the rat small intestine and liver. Eight-week-old male Sprague-Dawley rats were used in this study. OJ or a 0.079% hesperidin suspension was administered orally for 2 days. Tap water was given as a control. A single dose of PRV at 100 mg/kg p.o. was administered after 2 days of OJ, hesperidin, or tap water ingestion. The AUC, C(max), and t(1/2) values of PRV were significantly increased in OJ group. Mrp2 protein and mRNA levels in the small intestine and liver, respectively, were significantly decreased after the ingestion of OJ. The same results were obtained with hesperidin. These results suggest that the changes in PRV pharmacokinetic parameters and the decrease in Mrp2 expression caused by OJ are due to hesperidin in the juice.
DOI: 10.1155/2011/502057
PubMed: 21660137
Affiliations:
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Links to Exploration step
pubmed:21660137Le document en format XML
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wicri:level="1"><nlm:affiliation>Department of Pharmacology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, Kawasaki, Kanagawa 216-8511, Japan. m4wata@marianna-u.ac.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pharmacology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, Kawasaki, Kanagawa 216-8511</wicri:regionArea><wicri:noRegion>Kanagawa 216-8511</wicri:noRegion></affiliation></author><author><name sortKey="Matsumoto, Naoki" sort="Matsumoto, Naoki" uniqKey="Matsumoto N" first="Naoki" last="Matsumoto">Naoki Matsumoto</name></author><author><name sortKey="Takeba, Yuko" sort="Takeba, Yuko" uniqKey="Takeba Y" first="Yuko" last="Takeba">Yuko Takeba</name></author><author><name sortKey="Kumai, Toshio" sort="Kumai, Toshio" uniqKey="Kumai T" first="Toshio" last="Kumai">Toshio Kumai</name></author><author><name sortKey="Tanaka, Masami" sort="Tanaka, Masami" uniqKey="Tanaka M" first="Masami" last="Tanaka">Masami Tanaka</name></author><author><name sortKey="Tatsunami, Shinobu" sort="Tatsunami, Shinobu" uniqKey="Tatsunami S" first="Shinobu" last="Tatsunami">Shinobu Tatsunami</name></author><author><name sortKey="Takenoshita Nakaya, Sachiko" sort="Takenoshita Nakaya, Sachiko" uniqKey="Takenoshita Nakaya S" first="Sachiko" last="Takenoshita-Nakaya">Sachiko Takenoshita-Nakaya</name></author><author><name sortKey="Harimoto, Yoshie" sort="Harimoto, Yoshie" uniqKey="Harimoto Y" first="Yoshie" last="Harimoto">Yoshie Harimoto</name></author><author><name sortKey="Kinoshita, Yuichi" sort="Kinoshita, Yuichi" uniqKey="Kinoshita Y" first="Yuichi" last="Kinoshita">Yuichi Kinoshita</name></author><author><name sortKey="Kobayashi, Shinichi" sort="Kobayashi, Shinichi" uniqKey="Kobayashi S" first="Shinichi" last="Kobayashi">Shinichi Kobayashi</name></author></analytic><series><title level="j">Journal of biomedicine & biotechnology</title><idno type="eISSN">1110-7251</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Area Under Curve</term><term>Beverages</term><term>Citrus sinensis (chemistry)</term><term>Drug Administration Schedule</term><term>Hesperidin (pharmacology)</term><term>Intestine, Small (drug effects)</term><term>Intestine, Small (metabolism)</term><term>Liver (drug effects)</term><term>Liver (metabolism)</term><term>Male</term><term>Multidrug Resistance-Associated Proteins (drug effects)</term><term>Multidrug Resistance-Associated Proteins (metabolism)</term><term>Plasma (drug effects)</term><term>Plasma (metabolism)</term><term>Pravastatin (blood)</term><term>Pravastatin (pharmacokinetics)</term><term>RNA, Messenger (drug effects)</term><term>RNA, Messenger (metabolism)</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Pravastatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Multidrug Resistance-Associated Proteins</term><term>RNA, Messenger</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Multidrug Resistance-Associated Proteins</term><term>RNA, Messenger</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Pravastatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Hesperidin</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Intestine, Small</term><term>Liver</term><term>Plasma</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Intestine, Small</term><term>Liver</term><term>Plasma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Area Under Curve</term><term>Beverages</term><term>Drug Administration Schedule</term><term>Male</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated the effects of orange juice (OJ) or hesperidin, a component of OJ, on the pharmacokinetics of pravastatin (PRV) and the expression of both protein and mRNA of multidrug resistance-associated protein 2 (Mrp2) in the rat small intestine and liver. Eight-week-old male Sprague-Dawley rats were used in this study. OJ or a 0.079% hesperidin suspension was administered orally for 2 days. Tap water was given as a control. A single dose of PRV at 100 mg/kg p.o. was administered after 2 days of OJ, hesperidin, or tap water ingestion. The AUC, C(max), and t(1/2) values of PRV were significantly increased in OJ group. Mrp2 protein and mRNA levels in the small intestine and liver, respectively, were significantly decreased after the ingestion of OJ. The same results were obtained with hesperidin. These results suggest that the changes in PRV pharmacokinetic parameters and the decrease in Mrp2 expression caused by OJ are due to hesperidin in the juice.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21660137</PMID><DateCreated><Year>2011</Year><Month>6</Month><Day>10</Day></DateCreated><DateCompleted><Year>2011</Year><Month>10</Month><Day>03</Day></DateCompleted><DateRevised><Year>2015</Year><Month>2</Month><Day>4</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1110-7251</ISSN><JournalIssue CitedMedium="Internet"><Volume>2011</Volume><PubDate><Year>2011</Year></PubDate></JournalIssue><Title>Journal of biomedicine & biotechnology</Title><ISOAbbreviation>J. Biomed. Biotechnol.</ISOAbbreviation></Journal><ArticleTitle>Orange juice and its component, hesperidin, decrease the expression of multidrug resistance-associated protein 2 in rat small intestine and liver.</ArticleTitle><Pagination><MedlinePgn>502057</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1155/2011/502057</ELocationID><Abstract><AbstractText>We investigated the effects of orange juice (OJ) or hesperidin, a component of OJ, on the pharmacokinetics of pravastatin (PRV) and the expression of both protein and mRNA of multidrug resistance-associated protein 2 (Mrp2) in the rat small intestine and liver. Eight-week-old male Sprague-Dawley rats were used in this study. OJ or a 0.079% hesperidin suspension was administered orally for 2 days. Tap water was given as a control. A single dose of PRV at 100 mg/kg p.o. was administered after 2 days of OJ, hesperidin, or tap water ingestion. The AUC, C(max), and t(1/2) values of PRV were significantly increased in OJ group. Mrp2 protein and mRNA levels in the small intestine and liver, respectively, were significantly decreased after the ingestion of OJ. The same results were obtained with hesperidin. These results suggest that the changes in PRV pharmacokinetic parameters and the decrease in Mrp2 expression caused by OJ are due to hesperidin in the juice.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Watanabe</LastName><ForeName>Minoru</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, Kawasaki, Kanagawa 216-8511, Japan. m4wata@marianna-u.ac.jp</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matsumoto</LastName><ForeName>Naoki</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Takeba</LastName><ForeName>Yuko</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Kumai</LastName><ForeName>Toshio</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Tanaka</LastName><ForeName>Masami</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Tatsunami</LastName><ForeName>Shinobu</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Takenoshita-Nakaya</LastName><ForeName>Sachiko</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Harimoto</LastName><ForeName>Yoshie</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Kinoshita</LastName><ForeName>Yuichi</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Kobayashi</LastName><ForeName>Shinichi</ForeName><Initials>S</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>May</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Biomed Biotechnol</MedlineTA><NlmUniqueID>101135740</NlmUniqueID><ISSNLinking>1110-7243</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D027425">Multidrug Resistance-Associated Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C119001">multidrug resistance-associated protein 2</NameOfSubstance></Chemical><Chemical><RegistryNumber>E750O06Y6O</RegistryNumber><NameOfSubstance UI="D006569">Hesperidin</NameOfSubstance></Chemical><Chemical><RegistryNumber>KXO2KT9N0G</RegistryNumber><NameOfSubstance UI="D017035">Pravastatin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Clin Pharmacol Ther. 1999 Aug;66(2):118-27</RefSource><PMID 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Version="1">15530647</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019540" MajorTopicYN="N">Area Under Curve</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001628" MajorTopicYN="N">Beverages</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="N">Citrus sinensis</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004334" MajorTopicYN="N">Drug Administration Schedule</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006569" MajorTopicYN="N">Hesperidin</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007421" MajorTopicYN="N">Intestine, Small</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D027425" MajorTopicYN="N">Multidrug Resistance-Associated Proteins</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010949" MajorTopicYN="N">Plasma</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017035" MajorTopicYN="N">Pravastatin</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3110312</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>9</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2011</Year><Month>2</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>3</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>6</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>6</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>10</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21660137</ArticleId><ArticleId IdType="doi">10.1155/2011/502057</ArticleId><ArticleId IdType="pmc">PMC3110312</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Harimoto, Yoshie" sort="Harimoto, Yoshie" uniqKey="Harimoto Y" first="Yoshie" last="Harimoto">Yoshie Harimoto</name><name sortKey="Kinoshita, Yuichi" sort="Kinoshita, Yuichi" uniqKey="Kinoshita Y" first="Yuichi" last="Kinoshita">Yuichi Kinoshita</name><name sortKey="Kobayashi, Shinichi" sort="Kobayashi, Shinichi" uniqKey="Kobayashi S" first="Shinichi" last="Kobayashi">Shinichi Kobayashi</name><name sortKey="Kumai, Toshio" sort="Kumai, Toshio" uniqKey="Kumai T" first="Toshio" last="Kumai">Toshio Kumai</name><name sortKey="Matsumoto, Naoki" sort="Matsumoto, Naoki" uniqKey="Matsumoto N" first="Naoki" last="Matsumoto">Naoki Matsumoto</name><name sortKey="Takeba, Yuko" sort="Takeba, Yuko" uniqKey="Takeba Y" first="Yuko" last="Takeba">Yuko Takeba</name><name sortKey="Takenoshita Nakaya, Sachiko" sort="Takenoshita Nakaya, Sachiko" uniqKey="Takenoshita Nakaya S" first="Sachiko" last="Takenoshita-Nakaya">Sachiko Takenoshita-Nakaya</name><name sortKey="Tanaka, Masami" sort="Tanaka, Masami" uniqKey="Tanaka M" first="Masami" last="Tanaka">Masami Tanaka</name><name sortKey="Tatsunami, Shinobu" sort="Tatsunami, Shinobu" uniqKey="Tatsunami S" first="Shinobu" last="Tatsunami">Shinobu Tatsunami</name></noCountry><country name="Japon"><noRegion><name sortKey="Watanabe, Minoru" sort="Watanabe, Minoru" uniqKey="Watanabe M" first="Minoru" last="Watanabe">Minoru Watanabe</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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