Evaluation of the anti-proliferative and cytostatic effect of Citrus sinensis (orange) fruit juice.
Identifieur interne : 000345 ( PubMed/Checkpoint ); précédent : 000344; suivant : 000346Evaluation of the anti-proliferative and cytostatic effect of Citrus sinensis (orange) fruit juice.
Auteurs : Enegide Chinedu [Nigeria] ; David Arome [Nigeria] ; Solomon F. Ameh [Nigeria] ; Gift E. Ameh [Nigeria]Source :
- International journal of applied & basic medical research [ 2229-516X ] ; 2014.
Abstract
This work has been designed to evaluate the anti-proliferative and cytostatic effects of Citrus sinensis (orange) fruit juice on rapidly proliferating cells.
DOI: 10.4103/2229-516X.140711
PubMed: 25298937
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Ameh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Science Laboratory Technology (Physiology and Pharmacology Technology), University of Jos, Jos, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Science Laboratory Technology (Physiology and Pharmacology Technology), University of Jos, Jos</wicri:regionArea><wicri:noRegion>Jos</wicri:noRegion></affiliation></author><author><name sortKey="Ameh, Gift E" sort="Ameh, Gift E" uniqKey="Ameh G" first="Gift E" last="Ameh">Gift E. Ameh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacy, National Hospital, Abuja, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Pharmacy, National Hospital, Abuja</wicri:regionArea><wicri:noRegion>Abuja</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25298937</idno><idno type="pmid">25298937</idno><idno type="doi">10.4103/2229-516X.140711</idno><idno type="wicri:Area/PubMed/Corpus">000303</idno><idno type="wicri:Area/PubMed/Curation">000303</idno><idno type="wicri:Area/PubMed/Checkpoint">000303</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Evaluation of the anti-proliferative and cytostatic effect of Citrus sinensis (orange) fruit juice.</title><author><name sortKey="Chinedu, Enegide" sort="Chinedu, Enegide" uniqKey="Chinedu E" first="Enegide" last="Chinedu">Enegide Chinedu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Science Laboratory Technology (Physiology and Pharmacology Technology), University of Jos, Jos, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Science Laboratory Technology (Physiology and Pharmacology Technology), University of Jos, Jos</wicri:regionArea><wicri:noRegion>Jos</wicri:noRegion></affiliation></author><author><name sortKey="Arome, David" sort="Arome, David" uniqKey="Arome D" first="David" last="Arome">David Arome</name><affiliation wicri:level="1"><nlm:affiliation>Department of Science Laboratory Technology (Physiology and Pharmacology Technology), University of Jos, Jos, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Science Laboratory Technology (Physiology and Pharmacology Technology), University of Jos, Jos</wicri:regionArea><wicri:noRegion>Jos</wicri:noRegion></affiliation></author><author><name sortKey="Ameh, Solomon F" sort="Ameh, Solomon F" uniqKey="Ameh S" first="Solomon F" last="Ameh">Solomon F. Ameh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Science Laboratory Technology (Physiology and Pharmacology Technology), University of Jos, Jos, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Science Laboratory Technology (Physiology and Pharmacology Technology), University of Jos, Jos</wicri:regionArea><wicri:noRegion>Jos</wicri:noRegion></affiliation></author><author><name sortKey="Ameh, Gift E" sort="Ameh, Gift E" uniqKey="Ameh G" first="Gift E" last="Ameh">Gift E. Ameh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacy, National Hospital, Abuja, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Pharmacy, National Hospital, Abuja</wicri:regionArea><wicri:noRegion>Abuja</wicri:noRegion></affiliation></author></analytic><series><title level="j">International journal of applied & basic medical research</title><idno type="ISSN">2229-516X</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This work has been designed to evaluate the anti-proliferative and cytostatic effects of Citrus sinensis (orange) fruit juice on rapidly proliferating cells.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">25298937</PMID><DateCreated><Year>2014</Year><Month>10</Month><Day>9</Day></DateCreated><DateCompleted><Year>2014</Year><Month>10</Month><Day>09</Day></DateCompleted><DateRevised><Year>2014</Year><Month>10</Month><Day>11</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">2229-516X</ISSN><JournalIssue CitedMedium="Print"><Volume>4</Volume><Issue>Suppl 1</Issue><PubDate><Year>2014</Year><Month>Sep</Month></PubDate></JournalIssue><Title>International journal of applied & basic medical research</Title><ISOAbbreviation>Int J Appl Basic Med Res</ISOAbbreviation></Journal><ArticleTitle>Evaluation of the anti-proliferative and cytostatic effect of Citrus sinensis (orange) fruit juice.</ArticleTitle><Pagination><MedlinePgn>S20-2</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.4103/2229-516X.140711</ELocationID><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">This work has been designed to evaluate the anti-proliferative and cytostatic effects of Citrus sinensis (orange) fruit juice on rapidly proliferating cells.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">The study was carried out on the seeds of Sorghum bicolor for 72 h. The mean radicle length (mm) of the seeds was taken at 48 and 72 h.</AbstractText><AbstractText Label="RESULT" NlmCategory="RESULTS">The result showed that when compared with the control, methotrexate, the standard drug showed a significant (P < 0.001) anti-proliferative effect throughout the experiment. The inhibition of the radicle growth was more after 72 h (87.42%). At a dose of 5% (v/v), the juice showed a slightly significant (P < 0.05) effect affect after 72 h; however, there was no significant effect at 48 h. The juice at doses of 10% and 20% (v/v) showed a highly significant (P < 0.001) anti-proliferative effect throughout the experiment; however, the percentage inhibitions were higher at 72 h. At 72 h, the percentage inhibition for juice at 10% (v/v) was 72.37% and at 20% (v/v) was 91.96%. The concentrations of 40% and 60% (v/v) showed cytostatic effects as no appreciable growth of the radicles of the seeds was observed throughout the experiment. The percentage inhibition for 40% (v/v) was 100% and 99.72% for 48 and 72 h, respectively, while that for the juice concentration of 60% (v/v) was 100% throughout the study.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The experiment has shown that C. sinensis fruit juice has a potential for causing both anti-proliferative and cytostatic effects on fast proliferating cells and hence cancerous cells.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chinedu</LastName><ForeName>Enegide</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Science Laboratory Technology (Physiology and Pharmacology Technology), University of Jos, Jos, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arome</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Science Laboratory Technology (Physiology and Pharmacology Technology), University of Jos, Jos, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ameh</LastName><ForeName>Solomon F</ForeName><Initials>SF</Initials><AffiliationInfo><Affiliation>Department of Science Laboratory Technology (Physiology and Pharmacology Technology), University of Jos, Jos, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ameh</LastName><ForeName>Gift E</ForeName><Initials>GE</Initials><AffiliationInfo><Affiliation>Department of Pharmacy, National Hospital, Abuja, Nigeria.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>India</Country><MedlineTA>Int J Appl Basic Med Res</MedlineTA><NlmUniqueID>101579831</NlmUniqueID><ISSNLinking>2229-516X</ISSNLinking></MedlineJournalInfo><OtherID Source="NLM">PMC4181126</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anti-proliferative effect</Keyword><Keyword MajorTopicYN="N">Citrus sinensis</Keyword><Keyword MajorTopicYN="N">cytostatic effect</Keyword><Keyword MajorTopicYN="N">orange juice</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>8</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>1</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>10</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>10</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>10</Month><Day>10</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25298937</ArticleId><ArticleId IdType="doi">10.4103/2229-516X.140711</ArticleId><ArticleId IdType="pii">IJABMR-4-20</ArticleId><ArticleId IdType="pmc">PMC4181126</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Nigeria</li></country></list><tree><country name="Nigeria"><noRegion><name sortKey="Chinedu, Enegide" sort="Chinedu, Enegide" uniqKey="Chinedu E" first="Enegide" last="Chinedu">Enegide Chinedu</name></noRegion><name sortKey="Ameh, Gift E" sort="Ameh, Gift E" uniqKey="Ameh G" first="Gift E" last="Ameh">Gift E. Ameh</name><name sortKey="Ameh, Solomon F" sort="Ameh, Solomon F" uniqKey="Ameh S" first="Solomon F" last="Ameh">Solomon F. Ameh</name><name sortKey="Arome, David" sort="Arome, David" uniqKey="Arome D" first="David" last="Arome">David Arome</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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