A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models.
Identifieur interne : 000252 ( PubMed/Checkpoint ); précédent : 000251; suivant : 000253A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models.
Auteurs : Damião Pergentino De Sousa [Brésil] ; Palloma De Almeida Soares Hocayen [Brésil] ; Luciana Nalone Andrade [Brésil] ; Roberto Andreatini [Brésil]Source :
- Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2015.
English descriptors
- KwdEn :
- Achillea (chemistry), Alpinia (chemistry), Animals, Anti-Anxiety Agents (chemistry), Anti-Anxiety Agents (isolation & purification), Anti-Anxiety Agents (pharmacology), Anxiety (drug therapy), Anxiety (physiopathology), Citrus (chemistry), Controlled Clinical Trials as Topic, Disease Models, Animal, Humans, Lavandula (chemistry), Maze Learning (drug effects), Mice, Oils, Volatile (chemistry), Oils, Volatile (isolation & purification), Oils, Volatile (pharmacology), Plant Oils (chemistry), Plant Oils (isolation & purification), Plant Oils (pharmacology), Rats.
- MESH :
- chemical , chemistry : Anti-Anxiety Agents, Oils, Volatile, Plant Oils.
- chemistry : Achillea, Alpinia, Citrus, Lavandula.
- drug effects : Maze Learning.
- drug therapy : Anxiety.
- chemical , isolation & purification : Anti-Anxiety Agents, Oils, Volatile, Plant Oils.
- chemical , pharmacology : Anti-Anxiety Agents, Oils, Volatile, Plant Oils.
- physiopathology : Anxiety.
- Animals, Controlled Clinical Trials as Topic, Disease Models, Animal, Humans, Mice, Rats.
Abstract
The clinical efficacy of standardized essential oils (such as Lavender officinalis), in treating anxiety disorders strongly suggests that these natural products are an important candidate source for new anxiolytic drugs. A systematic review of essential oils, their bioactive constituents, and anxiolytic-like activity is conducted. The essential oil with the best profile is Lavendula angustifolia, which has already been tested in controlled clinical trials with positive results. Citrus aurantium using different routes of administration also showed significant effects in several animal models, and was corroborated by different research groups. Other promising essential oils are Citrus sinensis and bergamot oil, which showed certain clinical anxiolytic actions; along with Achillea wilhemsii, Alpinia zerumbet, Citrus aurantium, and Spiranthera odoratissima, which, like Lavendula angustifolia, appear to exert anxiolytic-like effects without GABA/benzodiazepine activity, thus differing in their mechanisms of action from the benzodiazepines. The anxiolytic activity of 25 compounds commonly found in essential oils is also discussed.
DOI: 10.3390/molecules201018620
PubMed: 26473822
Affiliations:
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xml:lang="fr">Brésil</country><wicri:regionArea>Departamento de Fisiologia, Universidade Federal de Sergipe, CEP 49100-000, São Cristóvão-SE</wicri:regionArea><placeName><region type="state">Sergipe</region></placeName></affiliation></author><author><name sortKey="Andreatini, Roberto" sort="Andreatini, Roberto" uniqKey="Andreatini R" first="Roberto" last="Andreatini">Roberto Andreatini</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Farmacologia, Universidade Federal do Paraná, CP 19031, Curitiba-PR, CEP 81540-970, Brazil. randreatini@ufpr.br.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Departamento de Farmacologia, Universidade Federal do Paraná, CP 19031, Curitiba-PR, CEP 81540-970</wicri:regionArea><wicri:noRegion>CEP 81540-970</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecules (Basel, Switzerland)</title><idno type="eISSN">1420-3049</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Achillea (chemistry)</term><term>Alpinia (chemistry)</term><term>Animals</term><term>Anti-Anxiety Agents (chemistry)</term><term>Anti-Anxiety Agents (isolation & purification)</term><term>Anti-Anxiety Agents (pharmacology)</term><term>Anxiety (drug therapy)</term><term>Anxiety (physiopathology)</term><term>Citrus (chemistry)</term><term>Controlled Clinical Trials as Topic</term><term>Disease Models, Animal</term><term>Humans</term><term>Lavandula (chemistry)</term><term>Maze Learning (drug effects)</term><term>Mice</term><term>Oils, Volatile (chemistry)</term><term>Oils, Volatile (isolation & purification)</term><term>Oils, Volatile (pharmacology)</term><term>Plant Oils (chemistry)</term><term>Plant Oils (isolation & purification)</term><term>Plant Oils (pharmacology)</term><term>Rats</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Anxiety Agents</term><term>Oils, Volatile</term><term>Plant Oils</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Achillea</term><term>Alpinia</term><term>Citrus</term><term>Lavandula</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Maze Learning</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Anxiety</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Anti-Anxiety Agents</term><term>Oils, Volatile</term><term>Plant Oils</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Anxiety Agents</term><term>Oils, Volatile</term><term>Plant Oils</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Anxiety</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Controlled Clinical Trials as Topic</term><term>Disease Models, Animal</term><term>Humans</term><term>Mice</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The clinical efficacy of standardized essential oils (such as Lavender officinalis), in treating anxiety disorders strongly suggests that these natural products are an important candidate source for new anxiolytic drugs. A systematic review of essential oils, their bioactive constituents, and anxiolytic-like activity is conducted. The essential oil with the best profile is Lavendula angustifolia, which has already been tested in controlled clinical trials with positive results. Citrus aurantium using different routes of administration also showed significant effects in several animal models, and was corroborated by different research groups. Other promising essential oils are Citrus sinensis and bergamot oil, which showed certain clinical anxiolytic actions; along with Achillea wilhemsii, Alpinia zerumbet, Citrus aurantium, and Spiranthera odoratissima, which, like Lavendula angustifolia, appear to exert anxiolytic-like effects without GABA/benzodiazepine activity, thus differing in their mechanisms of action from the benzodiazepines. The anxiolytic activity of 25 compounds commonly found in essential oils is also discussed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26473822</PMID><DateCreated><Year>2015</Year><Month>10</Month><Day>17</Day></DateCreated><DateCompleted><Year>2016</Year><Month>08</Month><Day>11</Day></DateCompleted><DateRevised><Year>2015</Year><Month>10</Month><Day>17</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1420-3049</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>10</Issue><PubDate><Year>2015</Year><Month>Oct</Month><Day>14</Day></PubDate></JournalIssue><Title>Molecules (Basel, Switzerland)</Title><ISOAbbreviation>Molecules</ISOAbbreviation></Journal><ArticleTitle>A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models.</ArticleTitle><Pagination><MedlinePgn>18620-60</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3390/molecules201018620</ELocationID><Abstract><AbstractText>The clinical efficacy of standardized essential oils (such as Lavender officinalis), in treating anxiety disorders strongly suggests that these natural products are an important candidate source for new anxiolytic drugs. A systematic review of essential oils, their bioactive constituents, and anxiolytic-like activity is conducted. The essential oil with the best profile is Lavendula angustifolia, which has already been tested in controlled clinical trials with positive results. Citrus aurantium using different routes of administration also showed significant effects in several animal models, and was corroborated by different research groups. Other promising essential oils are Citrus sinensis and bergamot oil, which showed certain clinical anxiolytic actions; along with Achillea wilhemsii, Alpinia zerumbet, Citrus aurantium, and Spiranthera odoratissima, which, like Lavendula angustifolia, appear to exert anxiolytic-like effects without GABA/benzodiazepine activity, thus differing in their mechanisms of action from the benzodiazepines. The anxiolytic activity of 25 compounds commonly found in essential oils is also discussed.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>de Sousa</LastName><ForeName>Damião Pergentino</ForeName><Initials>DP</Initials><AffiliationInfo><Affiliation>Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, CP 5009, João Pessoa-PB, CEP 58051-970, Brazil. damiao_desousa@yahoo.com.br.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Almeida Soares Hocayen</LastName><ForeName>Palloma</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Departamento de Farmacologia, Universidade Federal do Paraná, CP 19031, Curitiba-PR, CEP 81540-970, Brazil. pallomaas@yahoo.com.br.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andrade</LastName><ForeName>Luciana Nalone</ForeName><Initials>LN</Initials><AffiliationInfo><Affiliation>Departamento de Fisiologia, Universidade Federal de Sergipe, CEP 49100-000, São Cristóvão-SE, Brazil. lulisynalone@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andreatini</LastName><ForeName>Roberto</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Departamento de Farmacologia, Universidade Federal do Paraná, CP 19031, Curitiba-PR, CEP 81540-970, Brazil. randreatini@ufpr.br.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>Oct</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Molecules</MedlineTA><NlmUniqueID>100964009</NlmUniqueID><ISSNLinking>1420-3049</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014151">Anti-Anxiety Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009822">Oils, Volatile</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010938">Plant Oils</NameOfSubstance></Chemical><Chemical><RegistryNumber>8000-28-0</RegistryNumber><NameOfSubstance UI="C045718">lavender oil</NameOfSubstance></Chemical><Chemical><RegistryNumber>8007-75-8</RegistryNumber><NameOfSubstance UI="C068336">bergamot oil</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D031162" MajorTopicYN="N">Achillea</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032429" MajorTopicYN="N">Alpinia</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014151" MajorTopicYN="N">Anti-Anxiety Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001007" MajorTopicYN="N">Anxiety</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002957" MajorTopicYN="N">Citrus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018849" MajorTopicYN="N">Controlled Clinical Trials as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D027523" MajorTopicYN="N">Lavandula</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018782" MajorTopicYN="N">Maze Learning</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009822" MajorTopicYN="N">Oils, Volatile</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010938" MajorTopicYN="N">Plant Oils</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">anxiety</Keyword><Keyword MajorTopicYN="N">anxiolytic</Keyword><Keyword MajorTopicYN="N">elevated plus 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Andreatini</name><name sortKey="De Almeida Soares Hocayen, Palloma" sort="De Almeida Soares Hocayen, Palloma" uniqKey="De Almeida Soares Hocayen P" first="Palloma" last="De Almeida Soares Hocayen">Palloma De Almeida Soares Hocayen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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