Specific Selection of Essential Oil Compounds for Treatment of Children’s Infection Diseases
Identifieur interne : 001400 ( Pmc/Curation ); précédent : 001399; suivant : 001401Specific Selection of Essential Oil Compounds for Treatment of Children’s Infection Diseases
Auteurs : Alexander Pauli [Allemagne] ; Heinz Schilcher [Allemagne]Source :
- Pharmaceuticals [ 1424-8247 ] ; 2004.
Abstract
Preparations with essential oils and their dosages applied in the therapy of children’s infectious diseases are well documented. In contrast, information is only sparingly available about uses of isolated pure essential oil compounds for the treatment of such infections. To find out safe antimicrobials from essential oils, microbiological inhibitory data of children pathogens were combined with oral and dermal acute toxicity data to calculate oral and dermal therapeutical indices (TI). The superiority of antibiotic drugs became obvious following calculating oral TIs of antimicrobials from higher plants, which suggests that oral administrations of essential oil compounds are not suitable to cure severe infections. A few selected compounds from higher plants show moderate effectiveness against gram-positive bacteria, yeast and fungi, but not gram-negative bacteria. Topical application or inhalation of selected compounds for the treatment or additional treatment of mild infections is reasonable.
Url:
DOI: 10.3390/ph1010001
PubMed: NONE
PubMed Central: 3978485
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Specific Selection of Essential Oil Compounds for Treatment of Children’s Infection Diseases</title><author><name sortKey="Pauli, Alexander" sort="Pauli, Alexander" uniqKey="Pauli A" first="Alexander" last="Pauli">Alexander Pauli</name><affiliation wicri:level="1"><nlm:aff id="af1-pharmaceuticals-01-00001">ReviewScience, 90513 Zirndorf, Fürther Str. 13, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>ReviewScience, 90513 Zirndorf, Fürther Str. 13</wicri:regionArea></affiliation></author><author><name sortKey="Schilcher, Heinz" sort="Schilcher, Heinz" uniqKey="Schilcher H" first="Heinz" last="Schilcher">Heinz Schilcher</name><affiliation wicri:level="1"><nlm:aff id="af2-pharmaceuticals-01-00001">Heinz Schilcher, 81737 München, Alfred Neumann Anger 17, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Heinz Schilcher, 81737 München, Alfred Neumann Anger 17</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">3978485</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978485</idno><idno type="RBID">PMC:3978485</idno><idno type="doi">10.3390/ph1010001</idno><idno type="pmid">NONE</idno><date when="2004">2004</date><idno type="wicri:Area/Pmc/Corpus">001402</idno><idno type="wicri:Area/Pmc/Curation">001400</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Specific Selection of Essential Oil Compounds for Treatment of Children’s Infection Diseases</title><author><name sortKey="Pauli, Alexander" sort="Pauli, Alexander" uniqKey="Pauli A" first="Alexander" last="Pauli">Alexander Pauli</name><affiliation wicri:level="1"><nlm:aff id="af1-pharmaceuticals-01-00001">ReviewScience, 90513 Zirndorf, Fürther Str. 13, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>ReviewScience, 90513 Zirndorf, Fürther Str. 13</wicri:regionArea></affiliation></author><author><name sortKey="Schilcher, Heinz" sort="Schilcher, Heinz" uniqKey="Schilcher H" first="Heinz" last="Schilcher">Heinz Schilcher</name><affiliation wicri:level="1"><nlm:aff id="af2-pharmaceuticals-01-00001">Heinz Schilcher, 81737 München, Alfred Neumann Anger 17, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Heinz Schilcher, 81737 München, Alfred Neumann Anger 17</wicri:regionArea></affiliation></author></analytic><series><title level="j">Pharmaceuticals</title><idno type="eISSN">1424-8247</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Preparations with essential oils and their dosages applied in the therapy of children’s infectious diseases are well documented. In contrast, information is only sparingly available about uses of isolated pure essential oil compounds for the treatment of such infections. To find out safe antimicrobials from essential oils, microbiological inhibitory data of children pathogens were combined with oral and dermal acute toxicity data to calculate oral and dermal therapeutical indices (TI). The superiority of antibiotic drugs became obvious following calculating oral TIs of antimicrobials from higher plants, which suggests that oral administrations of essential oil compounds are not suitable to cure severe infections. A few selected compounds from higher plants show moderate effectiveness against gram-positive bacteria, yeast and fungi, but not gram-negative bacteria. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Pharmaceuticals (Basel)</journal-id><journal-id journal-id-type="iso-abbrev">Pharmaceuticals (Basel)</journal-id><journal-id journal-id-type="publisher-id">pharmaceuticals</journal-id><journal-title-group><journal-title>Pharmaceuticals</journal-title></journal-title-group><issn pub-type="epub">1424-8247</issn><publisher><publisher-name>MDPI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">3978485</article-id><article-id pub-id-type="doi">10.3390/ph1010001</article-id><article-id pub-id-type="publisher-id">pharmaceuticals-01-00001</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Specific Selection of Essential Oil Compounds for Treatment of Children’s Infection Diseases</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Pauli</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="af1-pharmaceuticals-01-00001">a</xref><xref rid="c1-pharmaceuticals-01-00001" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><name><surname>Schilcher</surname><given-names>Heinz</given-names></name><xref ref-type="aff" rid="af2-pharmaceuticals-01-00001">b</xref></contrib></contrib-group><aff id="af1-pharmaceuticals-01-00001"><label>a</label>ReviewScience, 90513 Zirndorf, Fürther Str. 13, Germany</aff><aff id="af2-pharmaceuticals-01-00001"><label>b</label>Heinz Schilcher, 81737 München, Alfred Neumann Anger 17, Germany</aff><author-notes><corresp id="c1-pharmaceuticals-01-00001"><label>*</label> Author to whom correspondence should be addressed; Email: <email>a.pauli@reviewscience.com</email></corresp></author-notes><pub-date pub-type="epub"><day>27</day><month>1</month><year>2004</year></pub-date><pub-date pub-type="collection"><month>1</month><year>2004</year></pub-date><volume>1</volume><issue>1</issue><fpage>1</fpage><lpage>30</lpage><history><date date-type="received"><day>15</day><month>12</month><year>2003</year></date><date date-type="accepted"><day>23</day><month>1</month><year>2004</year></date></history><permissions><copyright-statement>© 2004 by MDPI (http://www.mdpi.org).</copyright-statement><copyright-year>2004</copyright-year><license><license-p>Reproduction is permitted for noncommercial purposes.</license-p></license></permissions><abstract><p>Preparations with essential oils and their dosages applied in the therapy of children’s infectious diseases are well documented. In contrast, information is only sparingly available about uses of isolated pure essential oil compounds for the treatment of such infections. To find out safe antimicrobials from essential oils, microbiological inhibitory data of children pathogens were combined with oral and dermal acute toxicity data to calculate oral and dermal therapeutical indices (TI). The superiority of antibiotic drugs became obvious following calculating oral TIs of antimicrobials from higher plants, which suggests that oral administrations of essential oil compounds are not suitable to cure severe infections. A few selected compounds from higher plants show moderate effectiveness against gram-positive bacteria, yeast and fungi, but not gram-negative bacteria. Topical application or inhalation of selected compounds for the treatment or additional treatment of mild infections is reasonable.</p></abstract><kwd-group><kwd>Antibiotics</kwd><kwd>Antimycotics</kwd><kwd>Drugs Used in Dermatology</kwd><kwd>Essential Oils</kwd><kwd>Therapeutic Index</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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