Application of Omics Technologies for Evaluation of Antibacterial Mechanisms of Action of Plant-Derived Products
Identifieur interne : 001364 ( Pmc/Curation ); précédent : 001363; suivant : 001365Application of Omics Technologies for Evaluation of Antibacterial Mechanisms of Action of Plant-Derived Products
Auteurs : Bruno S. Dos Santos [Brésil] ; Luís C. N. Da Silva [Brésil] ; Túlio D. Da Silva [Brésil] ; João F. S. Rodrigues [Brésil] ; Marcos A. G. Grisotto [Brésil] ; Maria T. Dos Santos Correia [Brésil] ; Thiago H. Napoleão [Brésil] ; Márcia V. Da Silva [Brésil] ; Patrícia M. G. Paiva [Brésil]Source :
- Frontiers in Microbiology [ 1664-302X ] ; 2016.
Abstract
In the face of increasing bacterial resistance to antibiotics currently in use, the search for new antimicrobial agents has received a boost in recent years, with natural products playing an important role in this field. In fact, several methods have been proposed to investigate the antibacterial activities of natural products. However, given that the ultimate aim is future therapeutic use as novel drugs, it is extremely necessary to elucidate their modes of action, stating the molecular effects in detail, and identifying their targets in the bacterial cell. This review analyzes the application of “omics technologies” to understand the antibacterial mechanisms of bioactive natural products, to stimulate research interest in this area and promote scientific collaborations. Some studies have been specifically highlighted herein by examining their procedures and results (targeted proteins and metabolic pathways). These approaches have the potential to provide new insights into our comprehension of antimicrobial resistance/susceptibility, creating new perspectives for the struggle against bacteria, and leading to the development of novel products in the future.
Url:
DOI: 10.3389/fmicb.2016.01466
PubMed: 27729901
PubMed Central: 5037136
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Da Silva</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco</institution><country>Pernambuco, Brazil</country></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Paiva, Patricia M G" sort="Paiva, Patricia M G" uniqKey="Paiva P" first="Patrícia M. G." last="Paiva">Patrícia M. G. Paiva</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco</institution><country>Pernambuco, Brazil</country></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea></wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Microbiology</title><idno type="eISSN">1664-302X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In the face of increasing bacterial resistance to antibiotics currently in use, the search for new antimicrobial agents has received a boost in recent years, with natural products playing an important role in this field. In fact, several methods have been proposed to investigate the antibacterial activities of natural products. However, given that the ultimate aim is future therapeutic use as novel drugs, it is extremely necessary to elucidate their modes of action, stating the molecular effects in detail, and identifying their targets in the bacterial cell. This review analyzes the application of “omics technologies” to understand the antibacterial mechanisms of bioactive natural products, to stimulate research interest in this area and promote scientific collaborations. Some studies have been specifically highlighted herein by examining their procedures and results (targeted proteins and metabolic pathways). These approaches have the potential to provide new insights into our comprehension of antimicrobial resistance/susceptibility, creating new perspectives for the struggle against bacteria, and leading to the development of novel products in the future.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Aliferis, K A" uniqKey="Aliferis K">K. A. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Microbiol</journal-id><journal-id journal-id-type="iso-abbrev">Front Microbiol</journal-id><journal-id journal-id-type="publisher-id">Front. Microbiol.</journal-id><journal-title-group><journal-title>Frontiers in Microbiology</journal-title></journal-title-group><issn pub-type="epub">1664-302X</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27729901</article-id><article-id pub-id-type="pmc">5037136</article-id><article-id pub-id-type="doi">10.3389/fmicb.2016.01466</article-id><article-categories><subj-group subj-group-type="heading"><subject>Microbiology</subject><subj-group><subject>Mini Review</subject></subj-group></subj-group></article-categories><title-group><article-title>Application of Omics Technologies for Evaluation of Antibacterial Mechanisms of Action of Plant-Derived Products</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>dos Santos</surname><given-names>Bruno S.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn003"><sup>†</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/337728/overview"></uri></contrib><contrib contrib-type="author"><name><surname>da Silva</surname><given-names>Luís C. N.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="author-notes" rid="fn003"><sup>†</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/110773/overview"></uri></contrib><contrib contrib-type="author"><name><surname>da Silva</surname><given-names>Túlio D.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/312830/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Rodrigues</surname><given-names>João F. S.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Grisotto</surname><given-names>Marcos A. G.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/358791/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Correia</surname><given-names>Maria T. dos Santos</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/113318/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Napoleão</surname><given-names>Thiago H.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/90166/overview"></uri></contrib><contrib contrib-type="author"><name><surname>da Silva</surname><given-names>Márcia V.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/113182/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Paiva</surname><given-names>Patrícia M. G.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn001"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/168155/overview"></uri></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco</institution><country>Pernambuco, Brazil</country></aff><aff id="aff2"><sup>2</sup><institution>Programa de Pós-graduação em Biologia Parasitária, Universidade CEUMA</institution><country>Maranhão, Brazil</country></aff><aff id="aff3"><sup>3</sup><institution>Centro de Tecnologias Estratégicas do Nordeste</institution><country>Pernambuco, Brazil</country></aff><aff id="aff4"><sup>4</sup><institution>Instituto Florence de Ensino Superior</institution><country>Maranhão, Brazil</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Yuji Morita, Aichi Gakuin University, Japan</p></fn><fn fn-type="edited-by"><p>Reviewed by: Octavio Luiz Franco, Universidade Católica de Brasília, Brazil; Nitin Mantri, Royal Melbourne Institute of Technology University, Australia; Berna Sariyar Akbulut, Marmara University, Turkey</p></fn><corresp id="fn001">*Correspondence: Patrícia M. G. Paiva <email xlink:type="simple">ppaivaufpe@yahoo.com.br</email></corresp><fn fn-type="other" id="fn002"><p>This article was submitted to Antimicrobials, Resistance and Chemotherapy, a section of the journal Frontiers in Microbiology</p></fn><fn fn-type="other" id="fn003"><p>†These authors have contributed equally to this work.</p></fn></author-notes><pub-date pub-type="epub"><day>27</day><month>9</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>7</volume><elocation-id>1466</elocation-id><history><date date-type="received"><day>13</day><month>12</month><year>2015</year></date><date date-type="accepted"><day>01</day><month>9</month><year>2016</year></date></history><permissions><copyright-statement>Copyright © 2016 Santos, Silva, Silva, Rodrigues, Grisotto, Correia, Napoleão, Silva, Paiva.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Santos, Silva, Silva, Rodrigues, Grisotto, Correia, Napoleão, Silva, Paiva</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>In the face of increasing bacterial resistance to antibiotics currently in use, the search for new antimicrobial agents has received a boost in recent years, with natural products playing an important role in this field. In fact, several methods have been proposed to investigate the antibacterial activities of natural products. However, given that the ultimate aim is future therapeutic use as novel drugs, it is extremely necessary to elucidate their modes of action, stating the molecular effects in detail, and identifying their targets in the bacterial cell. This review analyzes the application of “omics technologies” to understand the antibacterial mechanisms of bioactive natural products, to stimulate research interest in this area and promote scientific collaborations. Some studies have been specifically highlighted herein by examining their procedures and results (targeted proteins and metabolic pathways). These approaches have the potential to provide new insights into our comprehension of antimicrobial resistance/susceptibility, creating new perspectives for the struggle against bacteria, and leading to the development of novel products in the future.</p></abstract><kwd-group><kwd>natural products</kwd><kwd>antimicrobial target</kwd><kwd>genomics</kwd><kwd>transcriptomics</kwd><kwd>proteomics</kwd><kwd>metabolomics</kwd></kwd-group><funding-group><award-group><funding-source id="cn001">Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<named-content content-type="fundref-id">10.13039/501100002322</named-content></funding-source></award-group><award-group><funding-source id="cn002">Conselho Nacional de Desenvolvimento Científico e Tecnológico<named-content content-type="fundref-id">10.13039/501100003593</named-content></funding-source></award-group><award-group><funding-source id="cn003">Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão<named-content content-type="fundref-id">10.13039/501100003758</named-content></funding-source></award-group></funding-group><counts><fig-count count="1"></fig-count><table-count count="1"></table-count><equation-count count="0"></equation-count><ref-count count="85"></ref-count><page-count count="13"></page-count><word-count count="7641"></word-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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