Screening the methanol extracts of some Iranian plants for acetylcholinesterase inhibitory activity
Identifieur interne : 001274 ( Pmc/Curation ); précédent : 001273; suivant : 001275Screening the methanol extracts of some Iranian plants for acetylcholinesterase inhibitory activity
Auteurs : A. Gholamhoseinian ; M. N. Moradi ; F. Sharifi-FarSource :
- Research in Pharmaceutical Sciences [ 1735-5362 ] ; 2009.
Abstract
Acetylcholinesterase (AChE) is the main enzyme for the breakdown of acetylcholine. Nowadays, usage of the inhibitors of this enzyme is one of the most important types of treatment of mild to moderate neurodegenerative diseases such as Alzheimer’s disease. Herbal medicines can be a new source of inhibitors of this enzyme. In this study we examined around 100 different plants to evaluate their inhibitory properties for AChE enzyme. Plants were scientifically identified and their extracts were prepared by methanol percolation. Acetylcholinesterase activity was measured using a colorimetric method in the presence or absence of the extracts. Eserine was used as a positive control. Methanol extracts of the
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PubMed: 21589805
PubMed Central: 3093628
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<author><name sortKey="Gholamhoseinian, A" sort="Gholamhoseinian, A" uniqKey="Gholamhoseinian A" first="A." last="Gholamhoseinian">A. Gholamhoseinian</name>
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<author><name sortKey="Moradi, M N" sort="Moradi, M N" uniqKey="Moradi M" first="M. N." last="Moradi">M. N. Moradi</name>
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<author><name sortKey="Sharifi Far, F" sort="Sharifi Far, F" uniqKey="Sharifi Far F" first="F." last="Sharifi-Far">F. Sharifi-Far</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Screening the methanol extracts of some Iranian plants for acetylcholinesterase inhibitory activity</title>
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<author><name sortKey="Sharifi Far, F" sort="Sharifi Far, F" uniqKey="Sharifi Far F" first="F." last="Sharifi-Far">F. Sharifi-Far</name>
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<front><div type="abstract" xml:lang="en"><p>Acetylcholinesterase (AChE) is the main enzyme for the breakdown of acetylcholine. Nowadays, usage of the inhibitors of this enzyme is one of the most important types of treatment of mild to moderate neurodegenerative diseases such as Alzheimer’s disease. Herbal medicines can be a new source of inhibitors of this enzyme. In this study we examined around 100 different plants to evaluate their inhibitory properties for AChE enzyme. Plants were scientifically identified and their extracts were prepared by methanol percolation. Acetylcholinesterase activity was measured using a colorimetric method in the presence or absence of the extracts. Eserine was used as a positive control. Methanol extracts of the <italic>Levisticum officinale, Bergeris integrima</italic>
and <italic>Rheum ribes</italic>
showed more than 50% AChE inhibitory activity. The inhibition kinetics were studied in the presence of the most effective extracts. <italic>L. officinale</italic>
and <italic>B. integrima</italic>
inhibited AChE activity in a non-competitive manner, while <italic>R. ribes</italic>
competitively inhibitied the enzyme as revealed by double-reciprocal Linweaver-Burk plot analysis. Under controlled condition, K<sub>m</sub>
and V<sub>max</sub>
values of the enzyme were found to be 9.4 mM and 0.238 mM/min, respectively. However, in the presence of <italic>L. officinale, B. integrima</italic>
, and <italic>R. ribes</italic>
extracts, V<sub>max</sub>
values were 0.192, 0.074 and 0.238 mM/min, respectively. Due to the competitive inhibition of the enzyme by <italic>R. ribes</italic>
extract, the K<sub>m</sub>
value of 21.2 mM was obtained. The concentration required for 50% enzyme inhibition (IC50 value) was 0.5, 0.9, and 0.95 mg/ml for the <italic>L. officinale, B. integrima</italic>
and <italic>R. ribes</italic>
extracts, respectively. The IC50 of the eserine was determined to be 0.8 mg/ml.</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Res Pharm Sci</journal-id>
<journal-id journal-id-type="publisher-id">JRPS</journal-id>
<journal-title-group><journal-title>Research in Pharmaceutical Sciences</journal-title>
</journal-title-group>
<issn pub-type="ppub">1735-5362</issn>
<issn pub-type="epub">1735-9414</issn>
<publisher><publisher-name>Medknow Publications</publisher-name>
<publisher-loc>India</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21589805</article-id>
<article-id pub-id-type="pmc">3093628</article-id>
<article-id pub-id-type="publisher-id">JRPS-4-105</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Screening the methanol extracts of some Iranian plants for acetylcholinesterase inhibitory activity</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Gholamhoseinian</surname>
<given-names>A.</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
<xref ref-type="aff" rid="AF0001">*</xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Moradi</surname>
<given-names>M.N.</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sharifi-far</surname>
<given-names>F.</given-names>
</name>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
</contrib-group>
<aff id="AF0001"><label>1</label>
<italic>Department of Biochemistry, Medical School and Kerman Physiology Research Center, Kerman University of Medical Sciences, Kerman, I.R.Iran</italic>
</aff>
<aff id="AF0002"><label>2</label>
<italic>Department of Pharmacognosy, School of Pharmacy, Kerman university of Medical Sciences, Kerman, I.R.Iran</italic>
</aff>
<author-notes><corresp id="cor1">*Corresponding author: Ahmad Gholamhoseinian Tel. 0098 341 322048, Fax. 0098 341 2261613 Email: <email xlink:href="agnajer@yahoo.com">agnajer@yahoo.com</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><season>Jul-Dec</season>
<year>2009</year>
</pub-date>
<volume>4</volume>
<issue>2</issue>
<fpage>105</fpage>
<lpage>112</lpage>
<history><date date-type="received"><month>5</month>
<year>2009</year>
</date>
<date date-type="accepted"><month>7</month>
<year>2009</year>
</date>
</history>
<permissions><copyright-statement>© Journal of Research in Pharmaceutical Sciences</copyright-statement>
<copyright-year>2009</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p>Acetylcholinesterase (AChE) is the main enzyme for the breakdown of acetylcholine. Nowadays, usage of the inhibitors of this enzyme is one of the most important types of treatment of mild to moderate neurodegenerative diseases such as Alzheimer’s disease. Herbal medicines can be a new source of inhibitors of this enzyme. In this study we examined around 100 different plants to evaluate their inhibitory properties for AChE enzyme. Plants were scientifically identified and their extracts were prepared by methanol percolation. Acetylcholinesterase activity was measured using a colorimetric method in the presence or absence of the extracts. Eserine was used as a positive control. Methanol extracts of the <italic>Levisticum officinale, Bergeris integrima</italic>
and <italic>Rheum ribes</italic>
showed more than 50% AChE inhibitory activity. The inhibition kinetics were studied in the presence of the most effective extracts. <italic>L. officinale</italic>
and <italic>B. integrima</italic>
inhibited AChE activity in a non-competitive manner, while <italic>R. ribes</italic>
competitively inhibitied the enzyme as revealed by double-reciprocal Linweaver-Burk plot analysis. Under controlled condition, K<sub>m</sub>
and V<sub>max</sub>
values of the enzyme were found to be 9.4 mM and 0.238 mM/min, respectively. However, in the presence of <italic>L. officinale, B. integrima</italic>
, and <italic>R. ribes</italic>
extracts, V<sub>max</sub>
values were 0.192, 0.074 and 0.238 mM/min, respectively. Due to the competitive inhibition of the enzyme by <italic>R. ribes</italic>
extract, the K<sub>m</sub>
value of 21.2 mM was obtained. The concentration required for 50% enzyme inhibition (IC50 value) was 0.5, 0.9, and 0.95 mg/ml for the <italic>L. officinale, B. integrima</italic>
and <italic>R. ribes</italic>
extracts, respectively. The IC50 of the eserine was determined to be 0.8 mg/ml.</p>
</abstract>
<kwd-group><kwd>Acetylcholinesterase</kwd>
<kwd>Inhibitor</kwd>
<kwd>Levisticum officinale</kwd>
<kwd>Bergeris integrima</kwd>
<kwd>Rheum ribes</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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