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Evaluation of the anti-proliferative and cytostatic effect of Citrus sinensis (orange) fruit juice

Identifieur interne : 000F68 ( Pmc/Curation ); précédent : 000F67; suivant : 000F69

Evaluation of the anti-proliferative and cytostatic effect of Citrus sinensis (orange) fruit juice

Auteurs : Enegide Chinedu [Nigeria] ; David Arome [Nigeria] ; Solomon F. Ameh [Nigeria] ; Gift E. Ameh [Nigeria]

Source :

RBID : PMC:4181126

Abstract

Aim:

This work has been designed to evaluate the anti-proliferative and cytostatic effects of Citrus sinensis (orange) fruit juice on rapidly proliferating cells.

Materials and Methods:

The study was carried out on the seeds of Sorghum bicolor for 72 h. The mean radicle length (mm) of the seeds was taken at 48 and 72 h.

Result:

The result showed that when compared with the control, methotrexate, the standard drug showed a significant (P < 0.001) anti-proliferative effect throughout the experiment. The inhibition of the radicle growth was more after 72 h (87.42%). At a dose of 5% (v/v), the juice showed a slightly significant (P < 0.05) effect affect after 72 h; however, there was no significant effect at 48 h. The juice at doses of 10% and 20% (v/v) showed a highly significant (P < 0.001) anti-proliferative effect throughout the experiment; however, the percentage inhibitions were higher at 72 h. At 72 h, the percentage inhibition for juice at 10% (v/v) was 72.37% and at 20% (v/v) was 91.96%. The concentrations of 40% and 60% (v/v) showed cytostatic effects as no appreciable growth of the radicles of the seeds was observed throughout the experiment. The percentage inhibition for 40% (v/v) was 100% and 99.72% for 48 and 72 h, respectively, while that for the juice concentration of 60% (v/v) was 100% throughout the study.

Conclusion:

The experiment has shown that C. sinensis fruit juice has a potential for causing both anti-proliferative and cytostatic effects on fast proliferating cells and hence cancerous cells.


Url:
DOI: 10.4103/2229-516X.140711
PubMed: 25298937
PubMed Central: 4181126

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PMC:4181126

Le document en format XML

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<nlm:aff id="aff1">Department of Science Laboratory Technology (Physiology and Pharmacology Technology), University of Jos, Jos, Nigeria</nlm:aff>
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<name sortKey="Chinedu, Enegide" sort="Chinedu, Enegide" uniqKey="Chinedu E" first="Enegide" last="Chinedu">Enegide Chinedu</name>
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<title>Aim:</title>
<p>This work has been designed to evaluate the anti-proliferative and cytostatic effects of
<italic>Citrus sinensis</italic>
(orange) fruit juice on rapidly proliferating cells.</p>
</sec>
<sec id="st2">
<title>Materials and Methods:</title>
<p>The study was carried out on the seeds of Sorghum bicolor for 72 h. The mean radicle length (mm) of the seeds was taken at 48 and 72 h.</p>
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<title>Result:</title>
<p>The result showed that when compared with the control, methotrexate, the standard drug showed a significant (
<italic>P</italic>
< 0.001) anti-proliferative effect throughout the experiment. The inhibition of the radicle growth was more after 72 h (87.42%). At a dose of 5% (v/v), the juice showed a slightly significant (
<italic>P</italic>
< 0.05) effect affect after 72 h; however, there was no significant effect at 48 h. The juice at doses of 10% and 20% (v/v) showed a highly significant (
<italic>P</italic>
< 0.001) anti-proliferative effect throughout the experiment; however, the percentage inhibitions were higher at 72 h. At 72 h, the percentage inhibition for juice at 10% (v/v) was 72.37% and at 20% (v/v) was 91.96%. The concentrations of 40% and 60% (v/v) showed cytostatic effects as no appreciable growth of the radicles of the seeds was observed throughout the experiment. The percentage inhibition for 40% (v/v) was 100% and 99.72% for 48 and 72 h, respectively, while that for the juice concentration of 60% (v/v) was 100% throughout the study.</p>
</sec>
<sec id="st4">
<title>Conclusion:</title>
<p>The experiment has shown that
<italic>C. sinensis</italic>
fruit juice has a potential for causing both anti-proliferative and cytostatic effects on fast proliferating cells and hence cancerous cells.</p>
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<name sortKey="Soejarto, Dd" uniqKey="Soejarto D">DD Soejarto</name>
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<journal-id journal-id-type="nlm-ta">Int J Appl Basic Med Res</journal-id>
<journal-id journal-id-type="iso-abbrev">Int J Appl Basic Med Res</journal-id>
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</article-categories>
<title-group>
<article-title>Evaluation of the anti-proliferative and cytostatic effect of
<italic>Citrus sinensis</italic>
(orange) fruit juice</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Chinedu</surname>
<given-names>Enegide</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Arome</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ameh</surname>
<given-names>Solomon F</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ameh</surname>
<given-names>Gift E</given-names>
</name>
<xref ref-type="aff" rid="aff2">1</xref>
</contrib>
</contrib-group>
<aff id="aff1">Department of Science Laboratory Technology (Physiology and Pharmacology Technology), University of Jos, Jos, Nigeria</aff>
<aff id="aff2">
<label>1</label>
Department of Pharmacy, National Hospital, Abuja, Nigeria</aff>
<author-notes>
<corresp id="cor1">
<bold>Address for correspondence:</bold>
Mr. Enegide Chinedu, Department of Science Laboratory Technology (Physiology and Pharmacology Technology), University of Jos, Jos, Nigeria. E-mail:
<email xlink:href="chinex.snow@gmail.com">chinex.snow@gmail.com</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub">
<month>9</month>
<year>2014</year>
</pub-date>
<volume>4</volume>
<issue>Suppl 1</issue>
<fpage>S20</fpage>
<lpage>S22</lpage>
<history>
<date date-type="received">
<day>15</day>
<month>8</month>
<year>2013</year>
</date>
<date date-type="accepted">
<day>26</day>
<month>1</month>
<year>2014</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright: © International Journal of Applied and Basic Medical Research</copyright-statement>
<copyright-year>2014</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0">
<license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract>
<sec id="st1">
<title>Aim:</title>
<p>This work has been designed to evaluate the anti-proliferative and cytostatic effects of
<italic>Citrus sinensis</italic>
(orange) fruit juice on rapidly proliferating cells.</p>
</sec>
<sec id="st2">
<title>Materials and Methods:</title>
<p>The study was carried out on the seeds of Sorghum bicolor for 72 h. The mean radicle length (mm) of the seeds was taken at 48 and 72 h.</p>
</sec>
<sec id="st3">
<title>Result:</title>
<p>The result showed that when compared with the control, methotrexate, the standard drug showed a significant (
<italic>P</italic>
< 0.001) anti-proliferative effect throughout the experiment. The inhibition of the radicle growth was more after 72 h (87.42%). At a dose of 5% (v/v), the juice showed a slightly significant (
<italic>P</italic>
< 0.05) effect affect after 72 h; however, there was no significant effect at 48 h. The juice at doses of 10% and 20% (v/v) showed a highly significant (
<italic>P</italic>
< 0.001) anti-proliferative effect throughout the experiment; however, the percentage inhibitions were higher at 72 h. At 72 h, the percentage inhibition for juice at 10% (v/v) was 72.37% and at 20% (v/v) was 91.96%. The concentrations of 40% and 60% (v/v) showed cytostatic effects as no appreciable growth of the radicles of the seeds was observed throughout the experiment. The percentage inhibition for 40% (v/v) was 100% and 99.72% for 48 and 72 h, respectively, while that for the juice concentration of 60% (v/v) was 100% throughout the study.</p>
</sec>
<sec id="st4">
<title>Conclusion:</title>
<p>The experiment has shown that
<italic>C. sinensis</italic>
fruit juice has a potential for causing both anti-proliferative and cytostatic effects on fast proliferating cells and hence cancerous cells.</p>
</sec>
</abstract>
<kwd-group>
<kwd>Anti-proliferative effect</kwd>
<kwd>
<italic>Citrus sinensis</italic>
</kwd>
<kwd>cytostatic effect</kwd>
<kwd>orange juice</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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