Anti-inflammatory effect of Moringa oleifera Lam. seeds on acetic acid-induced acute colitis in rats
Identifieur interne : 000D94 ( Pmc/Curation ); précédent : 000D93; suivant : 000D95Anti-inflammatory effect of Moringa oleifera Lam. seeds on acetic acid-induced acute colitis in rats
Auteurs : Mohsen Minaiyan ; Gholamreza Asghari ; Diana Taheri ; Mozhgan Saeidi ; Salar Nasr-EsfahaniSource :
- Avicenna Journal of Phytomedicine [ 2228-7930 ] ; 2014.
Abstract
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PubMed: 25050310
PubMed Central: 4103706
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Anti-inflammatory effect of <italic>Moringa oleifera</italic> Lam. seeds on acetic acid-induced acute colitis in rats</title><author><name sortKey="Minaiyan, Mohsen" sort="Minaiyan, Mohsen" uniqKey="Minaiyan M" first="Mohsen" last="Minaiyan">Mohsen Minaiyan</name><affiliation><nlm:aff id="aff1"><italic>Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I. R. Iran</italic></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><italic>Isfahan Pharmaceutical Sciences Research Center, Isfahan, I. R. Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Asghari, Gholamreza" sort="Asghari, Gholamreza" uniqKey="Asghari G" first="Gholamreza" last="Asghari">Gholamreza Asghari</name><affiliation><nlm:aff id="aff2"><italic>Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I. R. Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Taheri, Diana" sort="Taheri, Diana" uniqKey="Taheri D" first="Diana" last="Taheri">Diana Taheri</name><affiliation><nlm:aff id="aff3"><italic>Department of Clinical Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I. R. Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Saeidi, Mozhgan" sort="Saeidi, Mozhgan" uniqKey="Saeidi M" first="Mozhgan" last="Saeidi">Mozhgan Saeidi</name><affiliation><nlm:aff id="aff4"><italic>Isfahan Pharmaceutical Sciences Research Center, Isfahan, I. R. Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Nasr Esfahani, Salar" sort="Nasr Esfahani, Salar" uniqKey="Nasr Esfahani S" first="Salar" last="Nasr-Esfahani">Salar Nasr-Esfahani</name><affiliation><nlm:aff id="aff5"><italic>School of Medicine, Isfahan University of Medical Sciences, Isfahan, I. R. Iran</italic></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25050310</idno><idno type="pmc">4103706</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103706</idno><idno type="RBID">PMC:4103706</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000D95</idno><idno type="wicri:Area/Pmc/Curation">000D94</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Anti-inflammatory effect of <italic>Moringa oleifera</italic> Lam. seeds on acetic acid-induced acute colitis in rats</title><author><name sortKey="Minaiyan, Mohsen" sort="Minaiyan, Mohsen" uniqKey="Minaiyan M" first="Mohsen" last="Minaiyan">Mohsen Minaiyan</name><affiliation><nlm:aff id="aff1"><italic>Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I. R. Iran</italic></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><italic>Isfahan Pharmaceutical Sciences Research Center, Isfahan, I. R. Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Asghari, Gholamreza" sort="Asghari, Gholamreza" uniqKey="Asghari G" first="Gholamreza" last="Asghari">Gholamreza Asghari</name><affiliation><nlm:aff id="aff2"><italic>Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I. R. Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Taheri, Diana" sort="Taheri, Diana" uniqKey="Taheri D" first="Diana" last="Taheri">Diana Taheri</name><affiliation><nlm:aff id="aff3"><italic>Department of Clinical Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I. R. Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Saeidi, Mozhgan" sort="Saeidi, Mozhgan" uniqKey="Saeidi M" first="Mozhgan" last="Saeidi">Mozhgan Saeidi</name><affiliation><nlm:aff id="aff4"><italic>Isfahan Pharmaceutical Sciences Research Center, Isfahan, I. R. Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Nasr Esfahani, Salar" sort="Nasr Esfahani, Salar" uniqKey="Nasr Esfahani S" first="Salar" last="Nasr-Esfahani">Salar Nasr-Esfahani</name><affiliation><nlm:aff id="aff5"><italic>School of Medicine, Isfahan University of Medical Sciences, Isfahan, I. R. Iran</italic></nlm:aff></affiliation></author></analytic><series><title level="j">Avicenna Journal of Phytomedicine</title><idno type="ISSN">2228-7930</idno><idno type="eISSN">2228-7949</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Objective:</bold> Anti-inflammatory, immuno-modulatory, and antioxidant properties of <italic>Moringa oleifera </italic>Lam. suggest that it might have beneficial effects on colitis. The present study was performed to investigate the anticolitis effect of <italic>Moringa </italic><italic>oleifera</italic> seeds hydro-alcoholic extract (MSHE) and its chloroform fraction (MCF) on acetic acid-induced colitis in rats. </p><p><bold>Materials and Methods:</bold> Both MSHE and MCF with three increasing doses (50, 100, and 200 mg/kg) were administered orally to separate groups of male Wistar rats, 2 h before ulcer induction (using acetic acid 4%) and continued for 5 days. Prednisolone (4 mg/kg) and normal saline (1 ml/kg) were used in reference and control groups, respectively. All rats were sacrificed 24 h after the last dose (at day 6) and tissue injuries were assessed macroscopically and pathologically. </p><p><bold>Results:</bold> Extracts with three doses mentioned before were effective to reduce weight of distal colon (8 cm) as a marker for inflammation and tissue edema. Three doses of MSHE and two greater doses of MCF (100 and 200 mg/kg) were effective to reduce ulcer severity, area, and index as well as mucosal inflammation severity and extent, crypt damage, invasion involvement, total colitis index, and MPO activity compared with controls. MCF (50 mg/kg) was not significantly effective in reducing evaluated parameters of colitis compared with controls.</p><p><bold>Conclusion:</bold> It is concluded that MSHE and MCF were both effective to treat experimental colitis and this might be attributed to their similar major components, biophenols and flavonoids. Since the efficacy was evident even in low doses of MSHE, presence of active constituents with high potency in seeds is persuasive. </p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Anwar, F" uniqKey="Anwar F">F Anwar</name></author><author><name sortKey="Latif, S" uniqKey="Latif S">S Latif</name></author><author><name sortKey="Ashraf, M" uniqKey="Ashraf M">M Ashraf</name></author><author><name sortKey="Gilani, Ah" uniqKey="Gilani A">AH Gilani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caceres, A" uniqKey="Caceres A">A Caceres</name></author><author><name sortKey="Saravia, A" uniqKey="Saravia A">A Saravia</name></author><author><name sortKey="Rizzo, S" uniqKey="Rizzo S">S Rizzo</name></author><author><name sortKey="Zabala, L" uniqKey="Zabala L">L Zabala</name></author><author><name sortKey="Leon, Ed" uniqKey="Leon E">ED Leon</name></author><author><name sortKey="Nave, F" uniqKey="Nave F">F 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uniqKey="Verma A">AR Verma</name></author><author><name sortKey="Vijayakumar, M" uniqKey="Vijayakumar M">M Vijayakumar</name></author><author><name sortKey="Mathela, Cs" uniqKey="Mathela C">CS Mathela</name></author><author><name sortKey="Rao, Cv" uniqKey="Rao C">CV Rao</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Avicenna J Phytomed</journal-id><journal-id journal-id-type="iso-abbrev">Avicenna J Phytomed</journal-id><journal-id journal-id-type="publisher-id">IJP</journal-id><journal-title-group><journal-title>Avicenna Journal of Phytomedicine</journal-title></journal-title-group><issn pub-type="ppub">2228-7930</issn><issn pub-type="epub">2228-7949</issn><publisher><publisher-name>Mashhad University of Medical Sciences</publisher-name><publisher-loc>Mashhad, Iran</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25050310</article-id><article-id pub-id-type="pmc">4103706</article-id><article-id pub-id-type="publisher-id">ajp-4-127</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research Paper</subject></subj-group></article-categories><title-group><article-title>Anti-inflammatory effect of <italic>Moringa oleifera</italic> Lam. seeds on acetic acid-induced acute colitis in rats</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Minaiyan</surname><given-names>Mohsen</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Asghari</surname><given-names>Gholamreza</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Taheri</surname><given-names>Diana</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Saeidi</surname><given-names>Mozhgan</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Nasr-Esfahani</surname><given-names>Salar</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib></contrib-group><aff id="aff1"><label>1</label><italic>Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I. R. Iran</italic></aff><aff id="aff2"><label>2</label><italic>Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I. R. Iran</italic></aff><aff id="aff3"><label>3</label><italic>Department of Clinical Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I. R. Iran</italic></aff><aff id="aff4"><label>4</label><italic>Isfahan Pharmaceutical Sciences Research Center, Isfahan, I. R. Iran</italic></aff><aff id="aff5"><label>5</label><italic>School of Medicine, Isfahan University of Medical Sciences, Isfahan, I. R. Iran</italic></aff><author-notes><corresp id="cor1"><label>*</label>Corresponding Author: Tel: +983117922623, Fax: +983116680011, minaiyan@pharm.mui.ac.ir</corresp></author-notes><pub-date pub-type="ppub"><season>Mar-Apr</season><year>2014</year></pub-date><volume>4</volume><issue>2</issue><fpage>127</fpage><lpage>136</lpage><history><date date-type="received"><day>12</day><month>6</month><year>2013</year></date><date date-type="rev-recd"><day>15</day><month>7</month><year>2013</year></date><date date-type="accepted"><day>20</day><month>7</month><year>2013</year></date></history><abstract><p><bold>Objective:</bold> Anti-inflammatory, immuno-modulatory, and antioxidant properties of <italic>Moringa oleifera </italic>Lam. suggest that it might have beneficial effects on colitis. The present study was performed to investigate the anticolitis effect of <italic>Moringa </italic><italic>oleifera</italic> seeds hydro-alcoholic extract (MSHE) and its chloroform fraction (MCF) on acetic acid-induced colitis in rats. </p><p><bold>Materials and Methods:</bold> Both MSHE and MCF with three increasing doses (50, 100, and 200 mg/kg) were administered orally to separate groups of male Wistar rats, 2 h before ulcer induction (using acetic acid 4%) and continued for 5 days. Prednisolone (4 mg/kg) and normal saline (1 ml/kg) were used in reference and control groups, respectively. All rats were sacrificed 24 h after the last dose (at day 6) and tissue injuries were assessed macroscopically and pathologically. </p><p><bold>Results:</bold> Extracts with three doses mentioned before were effective to reduce weight of distal colon (8 cm) as a marker for inflammation and tissue edema. Three doses of MSHE and two greater doses of MCF (100 and 200 mg/kg) were effective to reduce ulcer severity, area, and index as well as mucosal inflammation severity and extent, crypt damage, invasion involvement, total colitis index, and MPO activity compared with controls. MCF (50 mg/kg) was not significantly effective in reducing evaluated parameters of colitis compared with controls.</p><p><bold>Conclusion:</bold> It is concluded that MSHE and MCF were both effective to treat experimental colitis and this might be attributed to their similar major components, biophenols and flavonoids. Since the efficacy was evident even in low doses of MSHE, presence of active constituents with high potency in seeds is persuasive. </p></abstract><kwd-group><title>Key Words</title><kwd><italic>Acetic acid</italic></kwd><kwd><italic>Colitis</italic></kwd><kwd><italic>Inflammation</italic></kwd><kwd><italic>Moringa oleifera Lam</italic>.</kwd><kwd><italic>Rats</italic></kwd><kwd><italic>Seeds extract</italic></kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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