Carum induced hypothyroidism: an interesting observation and an experiment
Identifieur interne : 000661 ( Pmc/Curation ); précédent : 000660; suivant : 000662Carum induced hypothyroidism: an interesting observation and an experiment
Auteurs : Seyede Maryam Naghibi [Iran] ; Mohamad Ramezani [Iran] ; Narjess Ayati [Iran] ; Seyed Rasoul Zakavi [Iran]Source :
- DARU Journal of Pharmaceutical Sciences [ 1560-8115 ] ; 2015.
Abstract
Url:
DOI: 10.1186/s40199-015-0094-9
PubMed: 25616491
PubMed Central: 4310175
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Carum induced hypothyroidism: an interesting observation and an experiment</title>
<author><name sortKey="Naghibi, Seyede Maryam" sort="Naghibi, Seyede Maryam" uniqKey="Naghibi S" first="Seyede Maryam" last="Naghibi">Seyede Maryam Naghibi</name>
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<front><div type="abstract" xml:lang="en"><p><italic>Carum carvi</italic>
is a widely available herb that has been used as a food additive and as a medication in traditional medicine for many years. Its potential biological effects include analgesic, anti-inflammatory, anti-anxiety and antispasmodic activities. We report a patient with papillary thyroid carcinoma who were under treatment with levothyroxine and experienced an elevated TSH level by ingestion of <italic>Carum carvi</italic>
. TSH level was increased to 60.3 mIU/L with no change in levothyroxine dosage and decreased to normal range after discontinuation of the <italic>Carum carvi</italic>
. Observing this dramatic change in TSH level by carum ingestion, carum carvi capsules was produced and one of the researcher tried the medication on herself with a dose of 40 mg/kg/day. She had a history of hypothyroidism and was taking 100 ugr/day of levothyroxine. TSH was markedly increased 2 weeks after ingestion of Carum carvi and returned to normal range 5 months after discontinuation of it. This case report shows the effect of consumption of Carum carvi in increasing TSH level in hypothyroid patients treating with levothyroxine. The exact mechanism of action of carum carvi remains unknown.</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Daru</journal-id>
<journal-id journal-id-type="iso-abbrev">Daru</journal-id>
<journal-title-group><journal-title>DARU Journal of Pharmaceutical Sciences</journal-title>
</journal-title-group>
<issn pub-type="ppub">1560-8115</issn>
<issn pub-type="epub">2008-2231</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25616491</article-id>
<article-id pub-id-type="pmc">4310175</article-id>
<article-id pub-id-type="publisher-id">94</article-id>
<article-id pub-id-type="doi">10.1186/s40199-015-0094-9</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject>
</subj-group>
</article-categories>
<title-group><article-title>Carum induced hypothyroidism: an interesting observation and an experiment</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Naghibi</surname>
<given-names>Seyede Maryam</given-names>
</name>
<address><email>naghibim851@mums.ac.ir</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ramezani</surname>
<given-names>Mohamad</given-names>
</name>
<address><email>ramezanim@mums.ac.ir</email>
</address>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ayati</surname>
<given-names>Narjess</given-names>
</name>
<address><email>ayatin@mums.ac.ir</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Zakavi</surname>
<given-names>Seyed Rasoul</given-names>
</name>
<address><email>zakavir@mums.ac.ir</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<aff id="Aff1"><label></label>
Nuclear Medicine Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</aff>
<aff id="Aff2"><label></label>
Pharmaceutical Research Center, Buali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran</aff>
</contrib-group>
<pub-date pub-type="epub"><day>24</day>
<month>1</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>24</day>
<month>1</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<volume>23</volume>
<issue>1</issue>
<elocation-id>5</elocation-id>
<history><date date-type="received"><day>3</day>
<month>4</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>12</day>
<month>1</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>© Naghibi et al.; licensee BioMed Central. 2015</copyright-statement>
<license license-type="open-access"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0">http://creativecommons.org/licenses/by/4.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><p><italic>Carum carvi</italic>
is a widely available herb that has been used as a food additive and as a medication in traditional medicine for many years. Its potential biological effects include analgesic, anti-inflammatory, anti-anxiety and antispasmodic activities. We report a patient with papillary thyroid carcinoma who were under treatment with levothyroxine and experienced an elevated TSH level by ingestion of <italic>Carum carvi</italic>
. TSH level was increased to 60.3 mIU/L with no change in levothyroxine dosage and decreased to normal range after discontinuation of the <italic>Carum carvi</italic>
. Observing this dramatic change in TSH level by carum ingestion, carum carvi capsules was produced and one of the researcher tried the medication on herself with a dose of 40 mg/kg/day. She had a history of hypothyroidism and was taking 100 ugr/day of levothyroxine. TSH was markedly increased 2 weeks after ingestion of Carum carvi and returned to normal range 5 months after discontinuation of it. This case report shows the effect of consumption of Carum carvi in increasing TSH level in hypothyroid patients treating with levothyroxine. The exact mechanism of action of carum carvi remains unknown.</p>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Thyroid</kwd>
<kwd>Carum carvi</kwd>
<kwd>TSH</kwd>
<kwd>Hypothyroidism</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2015</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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