Effects of Orange Juice Formulation on Prebiotic Functionality Using an In Vitro Colonic Model System
Identifieur interne : 000135 ( Pmc/Curation ); précédent : 000134; suivant : 000136Effects of Orange Juice Formulation on Prebiotic Functionality Using an In Vitro Colonic Model System
Auteurs : Adele Costabile [Royaume-Uni] ; Gemma E. Walton [Royaume-Uni] ; George Tzortzis [Royaume-Uni] ; Jelena Vulevic [Royaume-Uni] ; Dimitris Charalampopoulos [Royaume-Uni] ; Glenn R. Gibson [Royaume-Uni]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
A three-stage continuous fermentative colonic model system was used to monitor
Url:
DOI: 10.1371/journal.pone.0121955
PubMed: 25807417
PubMed Central: 4373861
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000135
Links to Exploration step
PMC:4373861Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of Orange Juice Formulation on Prebiotic Functionality Using an <italic>In Vitro</italic>
Colonic Model System</title>
<author><name sortKey="Costabile, Adele" sort="Costabile, Adele" uniqKey="Costabile A" first="Adele" last="Costabile">Adele Costabile</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Food and Nutritional Sciences, The University of Reading, Reading, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Food and Nutritional Sciences, The University of Reading, Reading</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Walton, Gemma E" sort="Walton, Gemma E" uniqKey="Walton G" first="Gemma E." last="Walton">Gemma E. Walton</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Food and Nutritional Sciences, The University of Reading, Reading, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Food and Nutritional Sciences, The University of Reading, Reading</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tzortzis, George" sort="Tzortzis, George" uniqKey="Tzortzis G" first="George" last="Tzortzis">George Tzortzis</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Clasado Research Services Ltd, Science and Technology Centre, Whiteknights, Reading, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clasado Research Services Ltd, Science and Technology Centre, Whiteknights, Reading</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vulevic, Jelena" sort="Vulevic, Jelena" uniqKey="Vulevic J" first="Jelena" last="Vulevic">Jelena Vulevic</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Clasado Research Services Ltd, Science and Technology Centre, Whiteknights, Reading, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clasado Research Services Ltd, Science and Technology Centre, Whiteknights, Reading</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Charalampopoulos, Dimitris" sort="Charalampopoulos, Dimitris" uniqKey="Charalampopoulos D" first="Dimitris" last="Charalampopoulos">Dimitris Charalampopoulos</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Food and Nutritional Sciences, The University of Reading, Reading, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Food and Nutritional Sciences, The University of Reading, Reading</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gibson, Glenn R" sort="Gibson, Glenn R" uniqKey="Gibson G" first="Glenn R." last="Gibson">Glenn R. Gibson</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Food and Nutritional Sciences, The University of Reading, Reading, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Food and Nutritional Sciences, The University of Reading, Reading</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25807417</idno>
<idno type="pmc">4373861</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373861</idno>
<idno type="RBID">PMC:4373861</idno>
<idno type="doi">10.1371/journal.pone.0121955</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000135</idno>
<idno type="wicri:Area/Pmc/Curation">000135</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effects of Orange Juice Formulation on Prebiotic Functionality Using an <italic>In Vitro</italic>
Colonic Model System</title>
<author><name sortKey="Costabile, Adele" sort="Costabile, Adele" uniqKey="Costabile A" first="Adele" last="Costabile">Adele Costabile</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Food and Nutritional Sciences, The University of Reading, Reading, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Food and Nutritional Sciences, The University of Reading, Reading</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Walton, Gemma E" sort="Walton, Gemma E" uniqKey="Walton G" first="Gemma E." last="Walton">Gemma E. Walton</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Food and Nutritional Sciences, The University of Reading, Reading, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Food and Nutritional Sciences, The University of Reading, Reading</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tzortzis, George" sort="Tzortzis, George" uniqKey="Tzortzis G" first="George" last="Tzortzis">George Tzortzis</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Clasado Research Services Ltd, Science and Technology Centre, Whiteknights, Reading, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clasado Research Services Ltd, Science and Technology Centre, Whiteknights, Reading</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vulevic, Jelena" sort="Vulevic, Jelena" uniqKey="Vulevic J" first="Jelena" last="Vulevic">Jelena Vulevic</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Clasado Research Services Ltd, Science and Technology Centre, Whiteknights, Reading, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clasado Research Services Ltd, Science and Technology Centre, Whiteknights, Reading</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Charalampopoulos, Dimitris" sort="Charalampopoulos, Dimitris" uniqKey="Charalampopoulos D" first="Dimitris" last="Charalampopoulos">Dimitris Charalampopoulos</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Food and Nutritional Sciences, The University of Reading, Reading, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Food and Nutritional Sciences, The University of Reading, Reading</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gibson, Glenn R" sort="Gibson, Glenn R" uniqKey="Gibson G" first="Glenn R." last="Gibson">Glenn R. Gibson</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Food and Nutritional Sciences, The University of Reading, Reading, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Food and Nutritional Sciences, The University of Reading, Reading</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>A three-stage continuous fermentative colonic model system was used to monitor <italic>in vitro</italic>
the effect of different orange juice formulations on prebiotic activity. Three different juices with and without Bimuno, a GOS mixture containing galactooligosaccharides (B-GOS) were assessed in terms of their ability to induce a bifidogenic microbiota. The recipe development was based on incorporating 2.75g B-GOS into a 250 ml serving of juice (65°Brix of concentrate juice). Alongside the production of B-GOS juice, a control juice – orange juice without any additional Bimuno and a positive control juice, containing all the components of Bimuno (glucose, galactose and lactose) in the same relative proportions with the exception of B-GOS were developed. Ion Exchange Chromotography analysis was used to test the maintenance of bimuno components after the production process. Data showed that sterilisation had no significant effect on concentration of B-GOS and simple sugars. The three juice formulations were digested under conditions resembling the gastric and small intestinal environments. Main bacterial groups of the faecal microbiota were evaluated throughout the colonic model study using 16S rRNA-based fluorescence in situ hybridization (FISH). Potential effects of supplementation of the juices on microbial metabolism were studied measuring short chain fatty acids (SCFAs) using gas chromatography. Furthermore, B-GOS juices showed positive modulations of the microbiota composition and metabolic activity. In particular, numbers of faecal bifidobacteria and lactobacilli were significantly higher when B-GOS juice was fermented compared to controls. Furthermore, fermentation of B-GOS juice resulted in an increase in <italic>Roseburia</italic>
subcluster and concomitantly increased butyrate production, which is of potential benefit to the host. In conclusion, this study has shown B-GOS within orange juice can have a beneficial effect on the fecal microbiota.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Steer, T" uniqKey="Steer T">T Steer</name>
</author>
<author><name sortKey="Carpenter, H" uniqKey="Carpenter H">H Carpenter</name>
</author>
<author><name sortKey="Tuohy, Km" uniqKey="Tuohy K">KM Tuohy</name>
</author>
<author><name sortKey="Gibson, Gr" uniqKey="Gibson G">GR Gibson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fuller, R" uniqKey="Fuller R">R Fuller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meydani, Sn" uniqKey="Meydani S">SN Meydani</name>
</author>
<author><name sortKey="Ha, Wk" uniqKey="Ha W">WK Ha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lupton, Jr" uniqKey="Lupton J">JR Lupton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gibson, Gr" uniqKey="Gibson G">GR Gibson</name>
</author>
<author><name sortKey="Roberfroid, Mb" uniqKey="Roberfroid M">MB Roberfroid</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Murphy, Ef" uniqKey="Murphy E">EF Murphy</name>
</author>
<author><name sortKey="Cotter, Pd" uniqKey="Cotter P">PD Cotter</name>
</author>
<author><name sortKey="Hogan, A" uniqKey="Hogan A">A Hogan</name>
</author>
<author><name sortKey="O Sullivan, O" uniqKey="O Sullivan O">O O'Sullivan</name>
</author>
<author><name sortKey="Joyce, A" uniqKey="Joyce A">A Joyce</name>
</author>
<author><name sortKey="Fouhy, F" uniqKey="Fouhy F">F Fouhy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Flint, Hj" uniqKey="Flint H">HJ Flint</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Silk, Dba" uniqKey="Silk D">DBA Silk</name>
</author>
<author><name sortKey="Davis, A" uniqKey="Davis A">A Davis</name>
</author>
<author><name sortKey="Vulevic, J" uniqKey="Vulevic J">J Vulevic</name>
</author>
<author><name sortKey="Tzortzis, G" uniqKey="Tzortzis G">G Tzortzis</name>
</author>
<author><name sortKey="Gibson, Gr" uniqKey="Gibson G">GR Gibson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vulevic, J" uniqKey="Vulevic J">J Vulevic</name>
</author>
<author><name sortKey="Drakoularakou, A" uniqKey="Drakoularakou A">A Drakoularakou</name>
</author>
<author><name sortKey="Yaqoob, P" uniqKey="Yaqoob P">P Yaqoob</name>
</author>
<author><name sortKey="Tzortzis, G" uniqKey="Tzortzis G">G Tzortzis</name>
</author>
<author><name sortKey="Gibson, Gr" uniqKey="Gibson G">GR Gibson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Depeint, F" uniqKey="Depeint F">F Depeint</name>
</author>
<author><name sortKey="Tzortzis, G" uniqKey="Tzortzis G">G Tzortzis</name>
</author>
<author><name sortKey="Vulevic, J" uniqKey="Vulevic J">J Vulevic</name>
</author>
<author><name sortKey="I Anson, K" uniqKey="I Anson K">K I'anson</name>
</author>
<author><name sortKey="Gibson, Gr" uniqKey="Gibson G">GR Gibson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bouhnik, Y" uniqKey="Bouhnik Y">Y Bouhnik</name>
</author>
<author><name sortKey="Raskine, L" uniqKey="Raskine L">L Raskine</name>
</author>
<author><name sortKey="Simoneau, G" uniqKey="Simoneau G">G Simoneau</name>
</author>
<author><name sortKey="Vicaut, E" uniqKey="Vicaut E">E Vicaut</name>
</author>
<author><name sortKey="Neut, C" uniqKey="Neut C">C Neut</name>
</author>
<author><name sortKey="Flourie, B" uniqKey="Flourie B">B Flourié</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ito, M" uniqKey="Ito M">M Ito</name>
</author>
<author><name sortKey="Deguchi, Y" uniqKey="Deguchi Y">Y Deguchi</name>
</author>
<author><name sortKey="Miyamori, A" uniqKey="Miyamori A">A Miyamori</name>
</author>
<author><name sortKey="Matsumoto, H" uniqKey="Matsumoto H">H Matsumoto</name>
</author>
<author><name sortKey="Kikuchi, K" uniqKey="Kikuchi K">K Kikuchi</name>
</author>
<author><name sortKey="Matsumoto, Y" uniqKey="Matsumoto Y">Y Matsumoto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fanaro, S" uniqKey="Fanaro S">S Fanaro</name>
</author>
<author><name sortKey="Marten, B" uniqKey="Marten B">B Marten</name>
</author>
<author><name sortKey="Bagna, R" uniqKey="Bagna R">R Bagna</name>
</author>
<author><name sortKey="Vigi, V" uniqKey="Vigi V">V Vigi</name>
</author>
<author><name sortKey="Fabris, C" uniqKey="Fabris C">C Fabris</name>
</author>
<author><name sortKey="Pe A Quintana, L" uniqKey="Pe A Quintana L">L Peña-Quintana</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sangwan, V" uniqKey="Sangwan V">V Sangwan</name>
</author>
<author><name sortKey="Tomar, Sk" uniqKey="Tomar S">SK Tomar</name>
</author>
<author><name sortKey="Singh, Rrb" uniqKey="Singh R">RRB Singh</name>
</author>
<author><name sortKey="Singh, Ak" uniqKey="Singh A">AK Singh</name>
</author>
<author><name sortKey="Ali, B" uniqKey="Ali B">B Ali</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Torres, Dpm" uniqKey="Torres D">DPM Torres</name>
</author>
<author><name sortKey="Goncalves, Mdf" uniqKey="Goncalves M">MDF Goncalves</name>
</author>
<author><name sortKey="Teixeira, Ja" uniqKey="Teixeira J">JA Teixeira</name>
</author>
<author><name sortKey="Rodrigues, Lr" uniqKey="Rodrigues L">LR Rodrigues</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Klewicki, R" uniqKey="Klewicki R">R Klewicki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Slegte, J" uniqKey="De Slegte J">J de Slegte</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maccaferri, S" uniqKey="Maccaferri S">S Maccaferri</name>
</author>
<author><name sortKey="Klinder, A" uniqKey="Klinder A">A Klinder</name>
</author>
<author><name sortKey="Cacciatore, S" uniqKey="Cacciatore S">S Cacciatore</name>
</author>
<author><name sortKey="Chitarrari, R" uniqKey="Chitarrari R">R Chitarrari</name>
</author>
<author><name sortKey="Honda, H" uniqKey="Honda H">H Honda</name>
</author>
<author><name sortKey="Luchinat, C" uniqKey="Luchinat C">C Luchinat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Macfarlane, G" uniqKey="Macfarlane G">G Macfarlane</name>
</author>
<author><name sortKey="Macfarlane, S" uniqKey="Macfarlane S">S Macfarlane</name>
</author>
<author><name sortKey="Gibson, Gr" uniqKey="Gibson G">GR Gibson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martin Pelaez, S" uniqKey="Martin Pelaez S">S Martín-Peláez</name>
</author>
<author><name sortKey="Gibson, Gr" uniqKey="Gibson G">GR Gibson</name>
</author>
<author><name sortKey="Martin Orue, Sm" uniqKey="Martin Orue S">SM Martín-Orúe</name>
</author>
<author><name sortKey="Klinder, A" uniqKey="Klinder A">A Klinder</name>
</author>
<author><name sortKey="Rastall, Ra" uniqKey="Rastall R">RA Rastall</name>
</author>
<author><name sortKey="La Ragione, Rm" uniqKey="La Ragione R">RM La Ragione</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Richardson, A" uniqKey="Richardson A">A Richardson</name>
</author>
<author><name sortKey="Calder, A" uniqKey="Calder A">A Calder</name>
</author>
<author><name sortKey="Stewart, C" uniqKey="Stewart C">C Stewart</name>
</author>
<author><name sortKey="Smith, A" uniqKey="Smith A">A Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Amann, Ri" uniqKey="Amann R">RI Amann</name>
</author>
<author><name sortKey="Binder, Bj" uniqKey="Binder B">BJ Binder</name>
</author>
<author><name sortKey="Olson, Rj" uniqKey="Olson R">RJ Olson</name>
</author>
<author><name sortKey="Chisholm, Sw" uniqKey="Chisholm S">SW Chisholm</name>
</author>
<author><name sortKey="Devereux, R" uniqKey="Devereux R">R Devereux</name>
</author>
<author><name sortKey="Stahl, Da" uniqKey="Stahl D">DA Stahl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Langendijk, Ps" uniqKey="Langendijk P">PS Langendijk</name>
</author>
<author><name sortKey="Schut, F" uniqKey="Schut F">F Schut</name>
</author>
<author><name sortKey="Jansen, Gj" uniqKey="Jansen G">GJ Jansen</name>
</author>
<author><name sortKey="Raangs, Gc" uniqKey="Raangs G">GC Raangs</name>
</author>
<author><name sortKey="Kamphuis, Gr" uniqKey="Kamphuis G">GR Kamphuis</name>
</author>
<author><name sortKey="Wilkinson, Mh" uniqKey="Wilkinson M">MH Wilkinson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Manz, W" uniqKey="Manz W">W Manz</name>
</author>
<author><name sortKey="Amann, R" uniqKey="Amann R">R Amann</name>
</author>
<author><name sortKey="Ludwig, W" uniqKey="Ludwig W">W Ludwig</name>
</author>
<author><name sortKey="Vancanneyt, M" uniqKey="Vancanneyt M">M Vancanneyt</name>
</author>
<author><name sortKey="Schleifer, Kh" uniqKey="Schleifer K">KH Schleifer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harmsen, Hjm" uniqKey="Harmsen H">HJM Harmsen</name>
</author>
<author><name sortKey="Elfferich, P" uniqKey="Elfferich P">P Elfferich</name>
</author>
<author><name sortKey="Schut, F" uniqKey="Schut F">F Schut</name>
</author>
<author><name sortKey="Welling, Gw" uniqKey="Welling G">GW Welling</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Franks, Ah" uniqKey="Franks A">AH Franks</name>
</author>
<author><name sortKey="Harmsen, Hj" uniqKey="Harmsen H">HJ Harmsen</name>
</author>
<author><name sortKey="Raangs, Gc" uniqKey="Raangs G">GC Raangs</name>
</author>
<author><name sortKey="Jansen, Gj" uniqKey="Jansen G">GJ Jansen</name>
</author>
<author><name sortKey="Schut, F" uniqKey="Schut F">F Schut</name>
</author>
<author><name sortKey="Welling, Gw" uniqKey="Welling G">GW Welling</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Walker, Aw" uniqKey="Walker A">AW Walker</name>
</author>
<author><name sortKey="Duncan, Sh" uniqKey="Duncan S">SH Duncan</name>
</author>
<author><name sortKey="Leitch, Ecm" uniqKey="Leitch E">ECM Leitch</name>
</author>
<author><name sortKey="Mcwilliam Leitch, Ec" uniqKey="Mcwilliam Leitch E">EC McWilliam Leitch</name>
</author>
<author><name sortKey="Child, Mw" uniqKey="Child M">MW Child</name>
</author>
<author><name sortKey="Flint, Hj" uniqKey="Flint H">HJ Flint</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lucker, S" uniqKey="Lucker S">S Lücker</name>
</author>
<author><name sortKey="Steger, D" uniqKey="Steger D">D Steger</name>
</author>
<author><name sortKey="Kjeldsen, Ku" uniqKey="Kjeldsen K">KU Kjeldsen</name>
</author>
<author><name sortKey="Macgregor, Bj" uniqKey="Macgregor B">BJ MacGregor</name>
</author>
<author><name sortKey="Wagner, M" uniqKey="Wagner M">M Wagner</name>
</author>
<author><name sortKey="Loy, A" uniqKey="Loy A">A Loy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Topping, Dl" uniqKey="Topping D">DL Topping</name>
</author>
<author><name sortKey="Clifton, Pm" uniqKey="Clifton P">PM Clifton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Falony, G" uniqKey="Falony G">G Falony</name>
</author>
<author><name sortKey="Vlachou, A" uniqKey="Vlachou A">A Vlachou</name>
</author>
<author><name sortKey="Verbrugghe, K" uniqKey="Verbrugghe K">K Verbrugghe</name>
</author>
<author><name sortKey="De Vuyst, L" uniqKey="De Vuyst L">L De Vuyst</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cherrington, Ca" uniqKey="Cherrington C">CA Cherrington</name>
</author>
<author><name sortKey="Hinton, M" uniqKey="Hinton M">M Hinton</name>
</author>
<author><name sortKey="Pearson, Gr" uniqKey="Pearson G">GR Pearson</name>
</author>
<author><name sortKey="Chopra, I" uniqKey="Chopra I">I Chopra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gibson, Gr" uniqKey="Gibson G">GR Gibson</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cani, Pd" uniqKey="Cani P">PD Cani</name>
</author>
<author><name sortKey="Bibiloni, R" uniqKey="Bibiloni R">R Bibiloni</name>
</author>
<author><name sortKey="Knauf, C" uniqKey="Knauf C">C Knauf</name>
</author>
<author><name sortKey="Waget, A" uniqKey="Waget A">A Waget</name>
</author>
<author><name sortKey="Neyrinck, Am" uniqKey="Neyrinck A">AM Neyrinck</name>
</author>
<author><name sortKey="Delzenne, Nm" uniqKey="Delzenne N">NM Delzenne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pachikian, Bd" uniqKey="Pachikian B">BD Pachikian</name>
</author>
<author><name sortKey="Essaghir, A" uniqKey="Essaghir A">A Essaghir</name>
</author>
<author><name sortKey="Demoulin, Jb" uniqKey="Demoulin J">JB Demoulin</name>
</author>
<author><name sortKey="Catry, E" uniqKey="Catry E">E Catry</name>
</author>
<author><name sortKey="Neyrinck, Am" uniqKey="Neyrinck A">AM Neyrinck</name>
</author>
<author><name sortKey="Dewulf, Em" uniqKey="Dewulf E">EM Dewulf</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group><journal-title>PLoS ONE</journal-title>
</journal-title-group>
<issn pub-type="epub">1932-6203</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, CA USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25807417</article-id>
<article-id pub-id-type="pmc">4373861</article-id>
<article-id pub-id-type="doi">10.1371/journal.pone.0121955</article-id>
<article-id pub-id-type="publisher-id">PONE-D-14-33813</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Effects of Orange Juice Formulation on Prebiotic Functionality Using an <italic>In Vitro</italic>
Colonic Model System</article-title>
<alt-title alt-title-type="running-head">Functionality of Prebiotic Containing Orange Juice</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Costabile</surname>
<given-names>Adele</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref rid="cor001" ref-type="corresp">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Walton</surname>
<given-names>Gemma E.</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tzortzis</surname>
<given-names>George</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vulevic</surname>
<given-names>Jelena</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Charalampopoulos</surname>
<given-names>Dimitris</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gibson</surname>
<given-names>Glenn R.</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff001"><label>1</label>
<addr-line>Department of Food and Nutritional Sciences, The University of Reading, Reading, United Kingdom</addr-line>
</aff>
<aff id="aff002"><label>2</label>
<addr-line>Clasado Research Services Ltd, Science and Technology Centre, Whiteknights, Reading, United Kingdom</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Blachier</surname>
<given-names>François</given-names>
</name>
<role>Academic Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>National Institute of Agronomic Research, FRANCE</addr-line>
</aff>
<author-notes><fn fn-type="conflict" id="coi001"><p><bold>Competing Interests: </bold>
The authors have the following interests: Jelena Vulevic and George Tzortzis, are employed by Clasado Ltd, who provided the B-GOS product, marketed as Bimuno, used within this research. There are no patents, products in development or other marketed products to declare. This does not alter the authors adherence to all the PLOS ONE policies on sharing data and materials.</p>
</fn>
<fn fn-type="con" id="contrib001"><p>Conceived and designed the experiments: AC GT GEW GRG. Performed the experiments: AC. Analyzed the data: AC GT GEW GRG. Contributed reagents/materials/analysis tools: AC. Wrote the paper: AC GEW GT JV DC GRG.</p>
</fn>
<corresp id="cor001">* E-mail: <email>a.costabile@reading.ac.uk</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>25</day>
<month>3</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<volume>10</volume>
<issue>3</issue>
<elocation-id>e0121955</elocation-id>
<history><date date-type="received"><day>30</day>
<month>7</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>6</day>
<month>2</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-year>2015</copyright-year>
<copyright-holder>Costabile et al</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>
, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="pone.0121955.pdf"></self-uri>
<abstract><p>A three-stage continuous fermentative colonic model system was used to monitor <italic>in vitro</italic>
the effect of different orange juice formulations on prebiotic activity. Three different juices with and without Bimuno, a GOS mixture containing galactooligosaccharides (B-GOS) were assessed in terms of their ability to induce a bifidogenic microbiota. The recipe development was based on incorporating 2.75g B-GOS into a 250 ml serving of juice (65°Brix of concentrate juice). Alongside the production of B-GOS juice, a control juice – orange juice without any additional Bimuno and a positive control juice, containing all the components of Bimuno (glucose, galactose and lactose) in the same relative proportions with the exception of B-GOS were developed. Ion Exchange Chromotography analysis was used to test the maintenance of bimuno components after the production process. Data showed that sterilisation had no significant effect on concentration of B-GOS and simple sugars. The three juice formulations were digested under conditions resembling the gastric and small intestinal environments. Main bacterial groups of the faecal microbiota were evaluated throughout the colonic model study using 16S rRNA-based fluorescence in situ hybridization (FISH). Potential effects of supplementation of the juices on microbial metabolism were studied measuring short chain fatty acids (SCFAs) using gas chromatography. Furthermore, B-GOS juices showed positive modulations of the microbiota composition and metabolic activity. In particular, numbers of faecal bifidobacteria and lactobacilli were significantly higher when B-GOS juice was fermented compared to controls. Furthermore, fermentation of B-GOS juice resulted in an increase in <italic>Roseburia</italic>
subcluster and concomitantly increased butyrate production, which is of potential benefit to the host. In conclusion, this study has shown B-GOS within orange juice can have a beneficial effect on the fecal microbiota.</p>
</abstract>
<funding-group><funding-statement>GW and AC were supported by the BBSRC grant (contract number BB/HOO4734/1). Jelena Vulevic and George Tzortzis, are employed by Clasado Ltd, who provided the B-GOS product used within this research. Clasado Ltd. provided support in the form of salaries for authors JV and GT, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement>
</funding-group>
<counts><fig-count count="2"></fig-count>
<table-count count="4"></table-count>
<page-count count="12"></page-count>
</counts>
<custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name>
<meta-value>All relevant data are within the paper.</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
<notes><title>Data Availability</title>
<p>All relevant data are within the paper.</p>
</notes>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/OrangerV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000135 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000135 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Bois |area= OrangerV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:4373861 |texte= Effects of Orange Juice Formulation on Prebiotic Functionality Using an In Vitro Colonic Model System }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:25807417" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a OrangerV1
This area was generated with Dilib version V0.6.25. |