Cytotoxicity of dietary flavonoids on different human cancer types
Identifieur interne : 001403 ( Pmc/Corpus ); précédent : 001402; suivant : 001404Cytotoxicity of dietary flavonoids on different human cancer types
Auteurs : Katrin SakSource :
- Pharmacognosy Reviews [ 0973-7847 ] ; 2014.
Abstract
Flavonoids are ubiquitous in nature. They are also in food, providing an essential link between diet and prevention of chronic diseases including cancer. Anticancer effects of these polyphenols depend on several factors: Their chemical structure and concentration, and also on the type of cancer. Malignant cells from different tissues reveal somewhat different sensitivity toward flavonoids and, therefore, the preferences of the most common dietary flavonoids to various human cancer types are analyzed in this review. While luteolin and kaempferol can be considered as promising candidate agents for treatment of gastric and ovarian cancers, respectively, apigenin, chrysin, and luteolin have good perspectives as potent antitumor agents for cervical cancer; cells from main sites of flavonoid metabolism (colon and liver) reveal rather large fluctuations in anticancer activity probably due to exposure to various metabolites with different activities. Anticancer effect of flavonoids toward blood cancer cells depend on their myeloid, lymphoid, or erythroid origin; cytotoxic effects of flavonoids on breast and prostate cancer cells are highly related to the expression of hormone receptors. Different flavonoids are often preferentially present in certain food items, and knowledge about the malignant tissue-specific anticancer effects of flavonoids could be purposely applied both in chemoprevention as well as in cancer treatment.
Url:
DOI: 10.4103/0973-7847.134247
PubMed: 25125885
PubMed Central: 4127821
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PMC:4127821Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cytotoxicity of dietary flavonoids on different human cancer types</title><author><name sortKey="Sak, Katrin" sort="Sak, Katrin" uniqKey="Sak K" first="Katrin" last="Sak">Katrin Sak</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25125885</idno><idno type="pmc">4127821</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127821</idno><idno type="RBID">PMC:4127821</idno><idno type="doi">10.4103/0973-7847.134247</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001403</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cytotoxicity of dietary flavonoids on different human cancer types</title><author><name sortKey="Sak, Katrin" sort="Sak, Katrin" uniqKey="Sak K" first="Katrin" last="Sak">Katrin Sak</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Pharmacognosy Reviews</title><idno type="ISSN">0973-7847</idno><idno type="eISSN">0976-2787</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Flavonoids are ubiquitous in nature. They are also in food, providing an essential link between diet and prevention of chronic diseases including cancer. Anticancer effects of these polyphenols depend on several factors: Their chemical structure and concentration, and also on the type of cancer. Malignant cells from different tissues reveal somewhat different sensitivity toward flavonoids and, therefore, the preferences of the most common dietary flavonoids to various human cancer types are analyzed in this review. While luteolin and kaempferol can be considered as promising candidate agents for treatment of gastric and ovarian cancers, respectively, apigenin, chrysin, and luteolin have good perspectives as potent antitumor agents for cervical cancer; cells from main sites of flavonoid metabolism (colon and liver) reveal rather large fluctuations in anticancer activity probably due to exposure to various metabolites with different activities. Anticancer effect of flavonoids toward blood cancer cells depend on their myeloid, lymphoid, or erythroid origin; cytotoxic effects of flavonoids on breast and prostate cancer cells are highly related to the expression of hormone receptors. Different flavonoids are often preferentially present in certain food items, and knowledge about the malignant tissue-specific anticancer effects of flavonoids could be purposely applied both in chemoprevention as well as in cancer treatment.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mignet, N" uniqKey="Mignet N">N Mignet</name></author><author><name sortKey="Seguin, J" uniqKey="Seguin J">J Seguin</name></author><author><name sortKey="Ramos, Romano M" uniqKey="Ramos R">Romano M Ramos</name></author><author><name sortKey="Brulle, L" uniqKey="Brulle L">L Brulle</name></author><author><name sortKey="Touil, Ys" uniqKey="Touil Y">YS Touil</name></author><author><name sortKey="Scherman, D" uniqKey="Scherman D">D Scherman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ying, Th" uniqKey="Ying T">TH Ying</name></author><author><name sortKey="Yang, Sf" uniqKey="Yang S">SF Yang</name></author><author><name sortKey="Tsai, Sj" uniqKey="Tsai S">SJ Tsai</name></author><author><name sortKey="Hsieh, Sc" uniqKey="Hsieh S">SC Hsieh</name></author><author><name sortKey="Huang, Yc" uniqKey="Huang Y">YC Huang</name></author><author><name sortKey="Bau, Dt" uniqKey="Bau D">DT Bau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Szliszka, E" uniqKey="Szliszka E">E Szliszka</name></author><author><name sortKey="Helewski, Kj" uniqKey="Helewski K">KJ Helewski</name></author><author><name sortKey="Mizgala, E" uniqKey="Mizgala E">E Mizgala</name></author><author><name sortKey="Krol, W" uniqKey="Krol W">W Krol</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seguin, J" uniqKey="Seguin J">J Seguin</name></author><author><name sortKey="Brulle, L" uniqKey="Brulle L">L Brullé</name></author><author><name sortKey="Boyer, R" uniqKey="Boyer R">R Boyer</name></author><author><name sortKey="Lu, Ym" uniqKey="Lu Y">YM Lu</name></author><author><name sortKey="Ramos, Romano M" uniqKey="Ramos R">Romano M Ramos</name></author><author><name sortKey="Touil, Ys" uniqKey="Touil Y">YS Touil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tolomeo, M" uniqKey="Tolomeo M">M Tolomeo</name></author><author><name sortKey="Grimaudo, S" uniqKey="Grimaudo S">S Grimaudo</name></author><author><name sortKey="Di Cristina, A" uniqKey="Di Cristina A">A Di Cristina</name></author><author><name sortKey="Pipitone, Rm" uniqKey="Pipitone R">RM Pipitone</name></author><author><name sortKey="Dusonchet, L" uniqKey="Dusonchet L">L Dusonchet</name></author><author><name sortKey="Meli, M" uniqKey="Meli M">M Meli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jaiswal, Jv" uniqKey="Jaiswal J">JV Jaiswal</name></author><author><name sortKey="Wadegaonkar, Pa" uniqKey="Wadegaonkar P">PA Wadegaonkar</name></author><author><name sortKey="Hajare, Sw" uniqKey="Hajare S">SW Hajare</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Ht" uniqKey="Zhang H">HT Zhang</name></author><author><name sortKey="Luo, H" uniqKey="Luo H">H Luo</name></author><author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name></author><author><name sortKey="Lan, Lb" uniqKey="Lan L">LB Lan</name></author><author><name sortKey="Fan, Dh" uniqKey="Fan D">DH Fan</name></author><author><name sortKey="Zhu, Kd" uniqKey="Zhu K">KD Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsiao, Yc" uniqKey="Hsiao Y">YC Hsiao</name></author><author><name sortKey="Hsieh, Ys" uniqKey="Hsieh Y">YS Hsieh</name></author><author><name sortKey="Kuo, Wh" uniqKey="Kuo W">WH Kuo</name></author><author><name sortKey="Chiou, Hl" uniqKey="Chiou H">HL Chiou</name></author><author><name sortKey="Yang, Sf" uniqKey="Yang S">SF Yang</name></author><author><name sortKey="Chiang, Wl" uniqKey="Chiang W">WL Chiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ou, Yc" uniqKey="Ou Y">YC Ou</name></author><author><name sortKey="Kuan, Yh" uniqKey="Kuan Y">YH Kuan</name></author><author><name sortKey="Li, Jr" uniqKey="Li J">JR Li</name></author><author><name sortKey="Raung, Sl" uniqKey="Raung S">SL Raung</name></author><author><name sortKey="Wang, Cc" uniqKey="Wang C">CC Wang</name></author><author><name sortKey="Hung, Yy" uniqKey="Hung Y">YY Hung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen, Sc" uniqKey="Shen S">SC Shen</name></author><author><name sortKey="Ko, Ch" uniqKey="Ko C">CH Ko</name></author><author><name sortKey="Tseng, Sw" uniqKey="Tseng S">SW Tseng</name></author><author><name sortKey="Tsai, Sh" uniqKey="Tsai S">SH Tsai</name></author><author><name sortKey="Chen, Yc" uniqKey="Chen Y">YC Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramesh, E" uniqKey="Ramesh E">E Ramesh</name></author><author><name sortKey="Alshatwi, Aa" uniqKey="Alshatwi A">AA Alshatwi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name></author><author><name sortKey="Shu, G" uniqKey="Shu G">G Shu</name></author><author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name></author><author><name sortKey="Mi, X" uniqKey="Mi X">X Mi</name></author><author><name sortKey="Mei, Z" uniqKey="Mei Z">Z Mei</name></author><author><name sortKey="Deng, X" uniqKey="Deng X">X Deng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name></author><author><name sortKey="Jung, Ch" uniqKey="Jung C">CH Jung</name></author><author><name sortKey="Jang, Bh" uniqKey="Jang B">BH Jang</name></author><author><name sortKey="Go, Hy" uniqKey="Go H">HY Go</name></author><author><name sortKey="Park, Jh" uniqKey="Park J">JH Park</name></author><author><name sortKey="Choi, Yk" uniqKey="Choi Y">YK Choi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Yl" uniqKey="Li Y">YL Li</name></author><author><name sortKey="Gan, Gp" uniqKey="Gan G">GP Gan</name></author><author><name sortKey="Zhang, Hz" uniqKey="Zhang H">HZ Zhang</name></author><author><name sortKey="Wu, Hz" uniqKey="Wu H">HZ Wu</name></author><author><name sortKey="Li, Cl" uniqKey="Li C">CL Li</name></author><author><name sortKey="Huang, Yp" uniqKey="Huang Y">YP Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Attoub, S" uniqKey="Attoub S">S Attoub</name></author><author><name sortKey="Hassan, Ah" uniqKey="Hassan A">AH Hassan</name></author><author><name sortKey="Vanhoecke, B" uniqKey="Vanhoecke B">B Vanhoecke</name></author><author><name sortKey="Iratni, R" uniqKey="Iratni R">R Iratni</name></author><author><name sortKey="Takahashi, T" uniqKey="Takahashi T">T Takahashi</name></author><author><name sortKey="Gaben, Am" uniqKey="Gaben A">AM Gaben</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li Weber, M" uniqKey="Li Weber M">M Li-Weber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Samarghandian, S" uniqKey="Samarghandian S">S Samarghandian</name></author><author><name sortKey="Afshari, Jt" uniqKey="Afshari J">JT Afshari</name></author><author><name sortKey="Davoodi, S" uniqKey="Davoodi S">S Davoodi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tundis, R" uniqKey="Tundis R">R Tundis</name></author><author><name sortKey="Loizzo, Mr" uniqKey="Loizzo M">MR Loizzo</name></author><author><name sortKey="Menichini, F" uniqKey="Menichini F">F Menichini</name></author><author><name sortKey="Bonesi, M" uniqKey="Bonesi M">M Bonesi</name></author><author><name sortKey="Colica, C" uniqKey="Colica C">C Colica</name></author><author><name sortKey="Menichini, F" uniqKey="Menichini F">F Menichini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kalim, Md" uniqKey="Kalim M">MD Kalim</name></author><author><name sortKey="Bhattacharyya, D" uniqKey="Bhattacharyya D">D Bhattacharyya</name></author><author><name sortKey="Banerjee, A" uniqKey="Banerjee A">A Banerjee</name></author><author><name sortKey="Chattopadhyay, S" uniqKey="Chattopadhyay S">S Chattopadhyay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Cz" uniqKey="Wang C">CZ Wang</name></author><author><name sortKey="Calway, Td" uniqKey="Calway T">TD Calway</name></author><author><name sortKey="Wen, Xd" uniqKey="Wen X">XD Wen</name></author><author><name sortKey="Smith, J" uniqKey="Smith J">J Smith</name></author><author><name sortKey="Yu, C" uniqKey="Yu C">C Yu</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abrahim, Nn" uniqKey="Abrahim N">NN Abrahim</name></author><author><name sortKey="Kanthimathi, Ms" uniqKey="Kanthimathi M">MS Kanthimathi</name></author><author><name sortKey="Abdul Aziz, A" uniqKey="Abdul Aziz A">A Abdul-Aziz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamedeyazdan, S" uniqKey="Hamedeyazdan S">S Hamedeyazdan</name></author><author><name sortKey="Fathiazad, F" uniqKey="Fathiazad F">F Fathiazad</name></author><author><name sortKey="Sharifi, S" uniqKey="Sharifi S">S Sharifi</name></author><author><name sortKey="Nazemiyeh, H" uniqKey="Nazemiyeh H">H Nazemiyeh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suttana, W" uniqKey="Suttana W">W Suttana</name></author><author><name sortKey="Mankhetkorn, S" uniqKey="Mankhetkorn S">S Mankhetkorn</name></author><author><name sortKey="Poompimon, W" uniqKey="Poompimon W">W Poompimon</name></author><author><name sortKey="Palagani, A" uniqKey="Palagani A">A Palagani</name></author><author><name sortKey="Zhokhov, S" uniqKey="Zhokhov S">S Zhokhov</name></author><author><name sortKey="Gerlo, S" uniqKey="Gerlo S">S Gerlo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanno, S" uniqKey="Kanno S">S Kanno</name></author><author><name sortKey="Tomizawa, A" uniqKey="Tomizawa A">A Tomizawa</name></author><author><name sortKey="Hiura, T" uniqKey="Hiura T">T Hiura</name></author><author><name sortKey="Osanai, Y" uniqKey="Osanai Y">Y Osanai</name></author><author><name sortKey="Shouji, A" uniqKey="Shouji A">A Shouji</name></author><author><name sortKey="Ujibe, M" uniqKey="Ujibe M">M Ujibe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bestwick, Cs" uniqKey="Bestwick C">CS Bestwick</name></author><author><name sortKey="Milne, L" uniqKey="Milne L">L Milne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morales, P" uniqKey="Morales P">P Morales</name></author><author><name sortKey="Haza, Ai" uniqKey="Haza A">AI Haza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chien, Cs" uniqKey="Chien C">CS Chien</name></author><author><name sortKey="Shen, Kh" uniqKey="Shen K">KH Shen</name></author><author><name sortKey="Huang, Js" uniqKey="Huang J">JS Huang</name></author><author><name sortKey="Ko, Sc" uniqKey="Ko S">SC Ko</name></author><author><name sortKey="Shih, Yw" uniqKey="Shih Y">YW Shih</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sato, F" uniqKey="Sato F">F Sato</name></author><author><name sortKey="Matsukawa, Y" uniqKey="Matsukawa Y">Y Matsukawa</name></author><author><name sortKey="Matsumoto, K" uniqKey="Matsumoto K">K Matsumoto</name></author><author><name sortKey="Nishino, H" uniqKey="Nishino H">H Nishino</name></author><author><name sortKey="Sakai, T" uniqKey="Sakai T">T Sakai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chung, Cs" uniqKey="Chung C">CS Chung</name></author><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name></author><author><name sortKey="Cheng, D" uniqKey="Cheng D">D Cheng</name></author><author><name sortKey="Birt, Df" uniqKey="Birt D">DF Birt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kilani Jaziri, S" uniqKey="Kilani Jaziri S">S Kilani-Jaziri</name></author><author><name sortKey="Frachet, V" uniqKey="Frachet V">V Frachet</name></author><author><name sortKey="Bhouri, W" uniqKey="Bhouri W">W Bhouri</name></author><author><name sortKey="Ghedira, K" uniqKey="Ghedira K">K Ghedira</name></author><author><name sortKey="Chekir Ghedira, L" uniqKey="Chekir Ghedira L">L Chekir-Ghedira</name></author><author><name sortKey="Ronot, X" uniqKey="Ronot X">X Ronot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Ej" uniqKey="Lee E">EJ Lee</name></author><author><name sortKey="Oh, Sy" uniqKey="Oh S">SY Oh</name></author><author><name sortKey="Sung, Mk" uniqKey="Sung M">MK Sung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bulzomi, P" uniqKey="Bulzomi P">P Bulzomi</name></author><author><name sortKey="Bolli, A" uniqKey="Bolli A">A Bolli</name></author><author><name sortKey="Galluzzo, P" uniqKey="Galluzzo P">P Galluzzo</name></author><author><name sortKey="Acconcia, F" uniqKey="Acconcia F">F Acconcia</name></author><author><name sortKey="Ascenzi, P" uniqKey="Ascenzi P">P Ascenzi</name></author><author><name sortKey="Marino, M" uniqKey="Marino M">M Marino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dai, Z" uniqKey="Dai Z">Z Dai</name></author><author><name sortKey="Nair, V" uniqKey="Nair V">V Nair</name></author><author><name sortKey="Khan, M" uniqKey="Khan M">M Khan</name></author><author><name sortKey="Ciolino, Hp" uniqKey="Ciolino H">HP Ciolino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morley, Kl" uniqKey="Morley K">KL Morley</name></author><author><name sortKey="Ferguson, Pj" uniqKey="Ferguson P">PJ Ferguson</name></author><author><name sortKey="Koropatnick, J" uniqKey="Koropatnick J">J Koropatnick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yin, F" uniqKey="Yin F">F Yin</name></author><author><name sortKey="Giuliano, Ae" uniqKey="Giuliano A">AE Giuliano</name></author><author><name sortKey="Law, Re" uniqKey="Law R">RE Law</name></author><author><name sortKey="Van Herle, Aj" uniqKey="Van Herle A">AJ Van Herle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takagaki, N" uniqKey="Takagaki N">N Takagaki</name></author><author><name sortKey="Sowa, Y" uniqKey="Sowa Y">Y Sowa</name></author><author><name sortKey="Oki, T" uniqKey="Oki T">T Oki</name></author><author><name sortKey="Nakanishi, R" uniqKey="Nakanishi R">R Nakanishi</name></author><author><name sortKey="Yogosawa, S" uniqKey="Yogosawa S">S Yogosawa</name></author><author><name sortKey="Sakai, T" uniqKey="Sakai T">T Sakai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pacifico, S" uniqKey="Pacifico S">S Pacifico</name></author><author><name sortKey="Scognamiglio, M" uniqKey="Scognamiglio M">M Scognamiglio</name></author><author><name sortKey="D Brosca, B" uniqKey="D Brosca B">B D’Abrosca</name></author><author><name sortKey="Piccolella, S" uniqKey="Piccolella S">S Piccolella</name></author><author><name sortKey="Tsafantakis, N" uniqKey="Tsafantakis N">N Tsafantakis</name></author><author><name sortKey="Gallicchio, M" uniqKey="Gallicchio M">M Gallicchio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeong, Jc" uniqKey="Jeong J">JC Jeong</name></author><author><name sortKey="Kim, Ms" uniqKey="Kim M">MS Kim</name></author><author><name sortKey="Kim, Th" uniqKey="Kim T">TH Kim</name></author><author><name sortKey="Kim, Yk" uniqKey="Kim Y">YK Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Da" uniqKey="Kim D">DA Kim</name></author><author><name sortKey="Jeon, Yk" uniqKey="Jeon Y">YK Jeon</name></author><author><name sortKey="Nam, Mj" uniqKey="Nam M">MJ Nam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amado, Ng" uniqKey="Amado N">NG Amado</name></author><author><name sortKey="Cerqueira, Dm" uniqKey="Cerqueira D">DM Cerqueira</name></author><author><name sortKey="Menezes, Fs" uniqKey="Menezes F">FS Menezes</name></author><author><name sortKey="Da Silva, Jf" uniqKey="Da Silva J">JF da Silva</name></author><author><name sortKey="Neto, Vm" uniqKey="Neto V">VM Neto</name></author><author><name sortKey="Abreu, Jg" uniqKey="Abreu J">JG Abreu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Er" uniqKey="Lee E">ER Lee</name></author><author><name sortKey="Kang, Yj" uniqKey="Kang Y">YJ Kang</name></author><author><name sortKey="Choi, Hy" uniqKey="Choi H">HY Choi</name></author><author><name sortKey="Kang, Gh" uniqKey="Kang G">GH Kang</name></author><author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name></author><author><name sortKey="Kim, Bw" uniqKey="Kim B">BW Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shih, Yw" uniqKey="Shih Y">YW Shih</name></author><author><name sortKey="Wu, Pf" uniqKey="Wu P">PF Wu</name></author><author><name sortKey="Lee, Yc" uniqKey="Lee Y">YC Lee</name></author><author><name sortKey="Shi, Md" uniqKey="Shi M">MD Shi</name></author><author><name sortKey="Chiang, Ta" uniqKey="Chiang T">TA Chiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ninomiya, M" uniqKey="Ninomiya M">M Ninomiya</name></author><author><name sortKey="Nishida, K" uniqKey="Nishida K">K Nishida</name></author><author><name sortKey="Tanaka, K" uniqKey="Tanaka K">K Tanaka</name></author><author><name sortKey="Watanabe, K" uniqKey="Watanabe K">K Watanabe</name></author><author><name sortKey="Koketsu, M" uniqKey="Koketsu M">M Koketsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Bd" uniqKey="Wang B">BD Wang</name></author><author><name sortKey="Yang, Zy" uniqKey="Yang Z">ZY Yang</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Cai, Tk" uniqKey="Cai T">TK Cai</name></author><author><name sortKey="Crewdson, P" uniqKey="Crewdson P">P Crewdson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lefort, Ec" uniqKey="Lefort E">EC Lefort</name></author><author><name sortKey="Blay, J" uniqKey="Blay J">J Blay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Vanalstyne, Pc" uniqKey="Vanalstyne P">PC VanAlstyne</name></author><author><name sortKey="Irons, Ka" uniqKey="Irons K">KA Irons</name></author><author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name></author><author><name sortKey="Stewart, Jw" uniqKey="Stewart J">JW Stewart</name></author><author><name sortKey="Birt, Df" uniqKey="Birt D">DF Birt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patel, D" uniqKey="Patel D">D Patel</name></author><author><name sortKey="Shukla, S" uniqKey="Shukla S">S Shukla</name></author><author><name sortKey="Gupta, S" uniqKey="Gupta S">S Gupta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khoo, By" uniqKey="Khoo B">BY Khoo</name></author><author><name sortKey="Chua, Sl" uniqKey="Chua S">SL Chua</name></author><author><name sortKey="Balaram, P" uniqKey="Balaram P">P Balaram</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, N" uniqKey="Li N">N Li</name></author><author><name sortKey="Liu, Jh" uniqKey="Liu J">JH Liu</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Yu, By" uniqKey="Yu B">BY Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guthrie, N" uniqKey="Guthrie N">N Guthrie</name></author><author><name sortKey="Carroll, Kk" uniqKey="Carroll K">KK Carroll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knowles, Lm" uniqKey="Knowles L">LM Knowles</name></author><author><name sortKey="Zigrossi, Da" uniqKey="Zigrossi D">DA Zigrossi</name></author><author><name sortKey="Tauber, Ra" uniqKey="Tauber R">RA Tauber</name></author><author><name sortKey="Hightower, C" uniqKey="Hightower C">C Hightower</name></author><author><name sortKey="Milner, Ja" uniqKey="Milner J">JA Milner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Torkin, R" uniqKey="Torkin R">R Torkin</name></author><author><name sortKey="Lavoie, Jf" uniqKey="Lavoie J">JF Lavoie</name></author><author><name sortKey="Kaplan, Dr" uniqKey="Kaplan D">DR Kaplan</name></author><author><name sortKey="Yeger, H" uniqKey="Yeger H">H Yeger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoshimizu, N" uniqKey="Yoshimizu N">N Yoshimizu</name></author><author><name sortKey="Otani, Y" uniqKey="Otani Y">Y Otani</name></author><author><name sortKey="Saikawa, Y" uniqKey="Saikawa Y">Y Saikawa</name></author><author><name sortKey="Kubota, T" uniqKey="Kubota T">T Kubota</name></author><author><name sortKey="Yoshida, M" uniqKey="Yoshida M">M Yoshida</name></author><author><name sortKey="Furukawa, T" uniqKey="Furukawa T">T Furukawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fotsis, T" uniqKey="Fotsis T">T Fotsis</name></author><author><name sortKey="Pepper, Ms" uniqKey="Pepper M">MS Pepper</name></author><author><name sortKey="Aktas, E" uniqKey="Aktas E">E Aktas</name></author><author><name sortKey="Breit, S" uniqKey="Breit S">S Breit</name></author><author><name sortKey="Rasku, S" uniqKey="Rasku S">S Rasku</name></author><author><name sortKey="Adlercreutz, H" uniqKey="Adlercreutz H">H Adlercreutz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fotsis, T" uniqKey="Fotsis T">T Fotsis</name></author><author><name sortKey="Pepper, Ms" uniqKey="Pepper M">MS Pepper</name></author><author><name sortKey="Montesano, R" uniqKey="Montesano R">R Montesano</name></author><author><name sortKey="Aktas, E" uniqKey="Aktas E">E Aktas</name></author><author><name sortKey="Breit, S" uniqKey="Breit S">S Breit</name></author><author><name sortKey="Schweigerer, L" uniqKey="Schweigerer L">L Schweigerer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lim Do, Y" uniqKey="Lim Do Y">Y Lim do</name></author><author><name sortKey="Jeong, Y" uniqKey="Jeong Y">Y Jeong</name></author><author><name sortKey="Tyner, Al" uniqKey="Tyner A">AL Tyner</name></author><author><name sortKey="Park, Jh" uniqKey="Park J">JH Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gupta, S" uniqKey="Gupta S">S Gupta</name></author><author><name sortKey="Afaq, F" uniqKey="Afaq F">F Afaq</name></author><author><name sortKey="Mukhtar, H" uniqKey="Mukhtar H">H Mukhtar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, E" uniqKey="Yuan E">E Yuan</name></author><author><name sortKey="Liu, B" uniqKey="Liu B">B Liu</name></author><author><name sortKey="Ning, Z" uniqKey="Ning Z">Z Ning</name></author><author><name sortKey="Chen, C" uniqKey="Chen C">C Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tokalov, Sv" uniqKey="Tokalov S">SV Tokalov</name></author><author><name sortKey="Abramyuk, Am" uniqKey="Abramyuk A">AM Abramyuk</name></author><author><name sortKey="Abolmaali, Nd" uniqKey="Abolmaali N">ND Abolmaali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Plochmann, K" uniqKey="Plochmann K">K Plochmann</name></author><author><name sortKey="Korte, G" uniqKey="Korte G">G Korte</name></author><author><name sortKey="Koutsilieri, E" uniqKey="Koutsilieri E">E Koutsilieri</name></author><author><name sortKey="Richling, E" uniqKey="Richling E">E Richling</name></author><author><name sortKey="Riederer, P" uniqKey="Riederer P">P Riederer</name></author><author><name sortKey="Rethwilm, A" uniqKey="Rethwilm A">A Rethwilm</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ben Sghaier, M" uniqKey="Ben Sghaier M">M Ben Sghaier</name></author><author><name sortKey="Skandrani, I" uniqKey="Skandrani I">I Skandrani</name></author><author><name sortKey="Nasr, N" uniqKey="Nasr N">N Nasr</name></author><author><name sortKey="Franca, Mg" uniqKey="Franca M">MG Franca</name></author><author><name sortKey="Chekir Ghedira, L" uniqKey="Chekir Ghedira L">L Chekir-Ghedira</name></author><author><name sortKey="Ghedira, K" uniqKey="Ghedira K">K Ghedira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirano, T" uniqKey="Hirano T">T Hirano</name></author><author><name sortKey="Abe, K" uniqKey="Abe K">K Abe</name></author><author><name sortKey="Gotoh, M" uniqKey="Gotoh M">M Gotoh</name></author><author><name sortKey="Oka, K" uniqKey="Oka K">K Oka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiu, Fl" uniqKey="Chiu F">FL Chiu</name></author><author><name sortKey="Lin, Jk" uniqKey="Lin J">JK Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galvez, M" uniqKey="Galvez M">M Galvez</name></author><author><name sortKey="Martin Cordero, C" uniqKey="Martin Cordero C">C Martin-Cordero</name></author><author><name sortKey="Lopez Lazaro, M" uniqKey="Lopez Lazaro M">M Lopez-Lazaro</name></author><author><name sortKey="Cortes, F" uniqKey="Cortes F">F Cortes</name></author><author><name sortKey="Ayuso, Mj" uniqKey="Ayuso M">MJ Ayuso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, Ej" uniqKey="Choi E">EJ Choi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Fl" uniqKey="Chan F">FL Chan</name></author><author><name sortKey="Choi, Hl" uniqKey="Choi H">HL Choi</name></author><author><name sortKey="Chen, Zy" uniqKey="Chen Z">ZY Chen</name></author><author><name sortKey="Chan, Ps" uniqKey="Chan P">PS Chan</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Androutsopoulos, Vp" uniqKey="Androutsopoulos V">VP Androutsopoulos</name></author><author><name sortKey="Ruparelia, K" uniqKey="Ruparelia K">K Ruparelia</name></author><author><name sortKey="Arroo, Rr" uniqKey="Arroo R">RR Arroo</name></author><author><name sortKey="Tsatsakis, Am" uniqKey="Tsatsakis A">AM Tsatsakis</name></author><author><name sortKey="Spandidos, Da" uniqKey="Spandidos D">DA Spandidos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seelinger, G" uniqKey="Seelinger G">G Seelinger</name></author><author><name sortKey="Merfort, I" uniqKey="Merfort I">I Merfort</name></author><author><name sortKey="Wolfle, U" uniqKey="Wolfle U">U Wölfle</name></author><author><name sortKey="Schempp, Cm" uniqKey="Schempp C">CM Schempp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benavente Garcia, O" uniqKey="Benavente Garcia O">O Benavente-Garcia</name></author><author><name sortKey="Castillo, J" uniqKey="Castillo J">J Castillo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="W Tjen, W" uniqKey="W Tjen W">W Wätjen</name></author><author><name sortKey="Weber, N" uniqKey="Weber N">N Weber</name></author><author><name sortKey="Lou, Yj" uniqKey="Lou Y">YJ Lou</name></author><author><name sortKey="Wang, Zq" uniqKey="Wang Z">ZQ Wang</name></author><author><name sortKey="Chovolou, Y" uniqKey="Chovolou Y">Y Chovolou</name></author><author><name sortKey="Kampkotter, A" uniqKey="Kampkotter A">A Kampkötter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cai, X" uniqKey="Cai X">X Cai</name></author><author><name sortKey="Ye, T" uniqKey="Ye T">T Ye</name></author><author><name sortKey="Liu, C" uniqKey="Liu C">C Liu</name></author><author><name sortKey="Lu, W" uniqKey="Lu W">W Lu</name></author><author><name sortKey="Lu, M" uniqKey="Lu M">M Lu</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Chen, Ay" uniqKey="Chen A">AY Chen</name></author><author><name sortKey="Li, M" uniqKey="Li M">M Li</name></author><author><name sortKey="Chen, C" uniqKey="Chen C">C Chen</name></author><author><name sortKey="Yao, Q" uniqKey="Yao Q">Q Yao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, Xf" uniqKey="Xu X">XF Xu</name></author><author><name sortKey="Cai, Bl" uniqKey="Cai B">BL Cai</name></author><author><name sortKey="Guan, Sm" uniqKey="Guan S">SM Guan</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Wu, Jz" uniqKey="Wu J">JZ Wu</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Wr" uniqKey="Lee W">WR Lee</name></author><author><name sortKey="Shen, Sc" uniqKey="Shen S">SC Shen</name></author><author><name sortKey="Lin, Hy" uniqKey="Lin H">HY Lin</name></author><author><name sortKey="Hou, Wc" uniqKey="Hou W">WC Hou</name></author><author><name sortKey="Yang, Ll" uniqKey="Yang L">LL Yang</name></author><author><name sortKey="Chen, Yc" uniqKey="Chen Y">YC Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Jh" uniqKey="Park J">JH Park</name></author><author><name sortKey="Jin, Cy" uniqKey="Jin C">CY Jin</name></author><author><name sortKey="Lee, Bk" uniqKey="Lee B">BK Lee</name></author><author><name sortKey="Kim, Gy" uniqKey="Kim G">GY Kim</name></author><author><name sortKey="Choi, Yh" uniqKey="Choi Y">YH Choi</name></author><author><name sortKey="Jeong, Yk" uniqKey="Jeong Y">YK Jeong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anter, J" uniqKey="Anter J">J Anter</name></author><author><name sortKey="Romero Jimenez, M" uniqKey="Romero Jimenez M">M Romero-Jimenez</name></author><author><name sortKey="Fernandez Badmar, Z" uniqKey="Fernandez Badmar Z">Z Fernandez-Badmar</name></author><author><name sortKey="Villatoro Pulido, M" uniqKey="Villatoro Pulido M">M Villatoro-Pulido</name></author><author><name sortKey="Analla, M" uniqKey="Analla M">M Analla</name></author><author><name sortKey="Alonso Moraga, A" uniqKey="Alonso Moraga A">A Alonso-Moraga</name></author><author><name sortKey="Et, Al0" uniqKey="Et A">al0 et</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, Ej" uniqKey="Choi E">EJ Choi</name></author><author><name sortKey="Kim, Gh" uniqKey="Kim G">GH Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kajimoto, S" uniqKey="Kajimoto S">S Kajimoto</name></author><author><name sortKey="Takanashi, N" uniqKey="Takanashi N">N Takanashi</name></author><author><name sortKey="Kajimoto, T" uniqKey="Kajimoto T">T Kajimoto</name></author><author><name sortKey="Xu, M" uniqKey="Xu M">M Xu</name></author><author><name sortKey="Cao, J" uniqKey="Cao J">J Cao</name></author><author><name sortKey="Masuda, Y" uniqKey="Masuda Y">Y Masuda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, Cc" uniqKey="Lin C">CC Lin</name></author><author><name sortKey="Kuo, Cl" uniqKey="Kuo C">CL Kuo</name></author><author><name sortKey="Lee, Mh" uniqKey="Lee M">MH Lee</name></author><author><name sortKey="Lai, Kc" uniqKey="Lai K">KC Lai</name></author><author><name sortKey="Lin, Jp" uniqKey="Lin J">JP Lin</name></author><author><name sortKey="Yang, Js" uniqKey="Yang J">JS Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fu, J" uniqKey="Fu J">J Fu</name></author><author><name sortKey="Chen, D" uniqKey="Chen D">D Chen</name></author><author><name sortKey="Zhao, B" uniqKey="Zhao B">B Zhao</name></author><author><name sortKey="Zhao, Z" uniqKey="Zhao Z">Z Zhao</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeong, Jh" uniqKey="Jeong J">JH Jeong</name></author><author><name sortKey="An, Jy" uniqKey="An J">JY An</name></author><author><name sortKey="Kwon, Yt" uniqKey="Kwon Y">YT Kwon</name></author><author><name sortKey="Rhee, Jg" uniqKey="Rhee J">JG Rhee</name></author><author><name sortKey="Lee, Yj" uniqKey="Lee Y">YJ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author><author><name sortKey="Jung, Ji" uniqKey="Jung J">Ji Jung</name></author><author><name sortKey="Cho, Hj" uniqKey="Cho H">HJ Cho</name></author><author><name sortKey="Lim, Dy" uniqKey="Lim D">DY Lim</name></author><author><name sortKey="Lee, Hs" uniqKey="Lee H">HS Lee</name></author><author><name sortKey="Chun, Hs" uniqKey="Chun H">HS Chun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shukla, S" uniqKey="Shukla S">S Shukla</name></author><author><name sortKey="Gupta, S" uniqKey="Gupta S">S Gupta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koide, T" uniqKey="Koide T">T Koide</name></author><author><name sortKey="Kamei, H" uniqKey="Kamei H">H Kamei</name></author><author><name sortKey="Hashimoto, Y" uniqKey="Hashimoto Y">Y Hashimoto</name></author><author><name sortKey="Kojima, T" uniqKey="Kojima T">T Kojima</name></author><author><name sortKey="Terabe, K" uniqKey="Terabe K">K Terabe</name></author><author><name sortKey="Umeda, T" uniqKey="Umeda T">T Umeda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neves, Mp" uniqKey="Neves M">MP Neves</name></author><author><name sortKey="Cidade, H" uniqKey="Cidade H">H Cidade</name></author><author><name sortKey="Pinto, M" uniqKey="Pinto M">M Pinto</name></author><author><name sortKey="Silva, Am" uniqKey="Silva A">AM Silva</name></author><author><name sortKey="Gales, L" uniqKey="Gales L">L Gales</name></author><author><name sortKey="Damas, Am" uniqKey="Damas A">AM Damas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leung, Hw" uniqKey="Leung H">HW Leung</name></author><author><name sortKey="Lin, Cj" uniqKey="Lin C">CJ Lin</name></author><author><name sortKey="Hour, Mj" uniqKey="Hour M">MJ Hour</name></author><author><name sortKey="Yang, Wh" uniqKey="Yang W">WH Yang</name></author><author><name sortKey="Wang, My" uniqKey="Wang M">MY Wang</name></author><author><name sortKey="Lee, Hz" uniqKey="Lee H">HZ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Habtemarium, S" uniqKey="Habtemarium S">S Habtemarium</name></author><author><name sortKey="Dagne, E" uniqKey="Dagne E">E Dagne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valdameri, G" uniqKey="Valdameri G">G Valdameri</name></author><author><name sortKey="Trombetta Lima, M" uniqKey="Trombetta Lima M">M Trombetta-Lima</name></author><author><name sortKey="Worfel, Pr" uniqKey="Worfel P">PR Worfel</name></author><author><name sortKey="Pires, Ar" uniqKey="Pires A">AR Pires</name></author><author><name sortKey="Martinez, Gr" uniqKey="Martinez G">GR Martinez</name></author><author><name sortKey="Noleto, Gr" uniqKey="Noleto G">GR Noleto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, L" uniqKey="Yuan L">L Yuan</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Xiao, H" uniqKey="Xiao H">H Xiao</name></author><author><name sortKey="Xiao, C" uniqKey="Xiao C">C Xiao</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name></author><author><name sortKey="Xin, Y" uniqKey="Xin Y">Y Xin</name></author><author><name sortKey="Diao, Y" uniqKey="Diao Y">Y Diao</name></author><author><name sortKey="Lu, C" uniqKey="Lu C">C Lu</name></author><author><name sortKey="Fu, J" uniqKey="Fu J">J Fu</name></author><author><name sortKey="Luo, L" uniqKey="Luo L">L Luo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsai, Cf" uniqKey="Tsai C">CF Tsai</name></author><author><name sortKey="Yeh, Wl" uniqKey="Yeh W">WL Yeh</name></author><author><name sortKey="Huang, Sm" uniqKey="Huang S">SM Huang</name></author><author><name sortKey="Tan, Tw" uniqKey="Tan T">TW Tan</name></author><author><name sortKey="Lu, Dy" uniqKey="Lu D">DY Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsuo, M" uniqKey="Matsuo M">M Matsuo</name></author><author><name sortKey="Sasaki, N" uniqKey="Sasaki N">N Sasaki</name></author><author><name sortKey="Saga, K" uniqKey="Saga K">K Saga</name></author><author><name sortKey="Kaneko, T" uniqKey="Kaneko T">T Kaneko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agullo, G" uniqKey="Agullo G">G Agullo</name></author><author><name sortKey="Gamet Payrastre, L" uniqKey="Gamet Payrastre L">L Gamet-Payrastre</name></author><author><name sortKey="Fernandez, Y" uniqKey="Fernandez Y">Y Fernandez</name></author><author><name sortKey="Anciaux, N" uniqKey="Anciaux N">N Anciaux</name></author><author><name sortKey="Demigne, C" uniqKey="Demigne C">C Demigne</name></author><author><name sortKey="Remesy, C" uniqKey="Remesy C">C Rémésy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Kw" uniqKey="Lee K">KW Lee</name></author><author><name sortKey="Hur, Hj" uniqKey="Hur H">HJ Hur</name></author><author><name sortKey="Lee, Hj" uniqKey="Lee H">HJ Lee</name></author><author><name sortKey="Lee, Cy" uniqKey="Lee C">CY Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Talib, Wh" uniqKey="Talib W">WH Talib</name></author><author><name sortKey="Zarga, Mh" uniqKey="Zarga M">MH Zarga</name></author><author><name sortKey="Mahasneh, Am" uniqKey="Mahasneh A">AM Mahasneh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benavente Garcia, O" uniqKey="Benavente Garcia O">O Benavente-Garcia</name></author><author><name sortKey="Castillo, J" uniqKey="Castillo J">J Castillo</name></author><author><name sortKey="Lorente, J" uniqKey="Lorente J">J Lorente</name></author><author><name sortKey="Alcaraz, M" uniqKey="Alcaraz M">M Alcaraz</name></author><author><name sortKey="Yanez, J" uniqKey="Yanez J">J Yanez</name></author><author><name sortKey="Martinez, C" uniqKey="Martinez C">C Martinez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez, J" uniqKey="Rodriguez J">J Rodriguez</name></author><author><name sortKey="Yanez, J" uniqKey="Yanez J">J Yanez</name></author><author><name sortKey="Vicente, V" uniqKey="Vicente V">V Vicente</name></author><author><name sortKey="Alcaraz, M" uniqKey="Alcaraz M">M Alcaraz</name></author><author><name sortKey="Benavente Garcia, O" uniqKey="Benavente Garcia O">O Benavente-Garcia</name></author><author><name sortKey="Castillo, J" uniqKey="Castillo J">J Castillo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ragazzon, Pa" uniqKey="Ragazzon P">PA Ragazzon</name></author><author><name sortKey="Bradshaw, T" uniqKey="Bradshaw T">T Bradshaw</name></author><author><name sortKey="Matthews, C" uniqKey="Matthews C">C Matthews</name></author><author><name sortKey="Iley, J" uniqKey="Iley J">J Iley</name></author><author><name sortKey="Missailidis, S" uniqKey="Missailidis S">S Missailidis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mamadalieva, Nz" uniqKey="Mamadalieva N">NZ Mamadalieva</name></author><author><name sortKey="Herrmann, F" uniqKey="Herrmann F">F Herrmann</name></author><author><name sortKey="El Readi, Mz" uniqKey="El Readi M">MZ El-Readi</name></author><author><name sortKey="Tahrani, A" uniqKey="Tahrani A">A Tahrani</name></author><author><name sortKey="Hamoud, R" uniqKey="Hamoud R">R Hamoud</name></author><author><name sortKey="Egamberdieva, Dr" uniqKey="Egamberdieva D">DR Egamberdieva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rao, Ps" uniqKey="Rao P">PS Rao</name></author><author><name sortKey="Satelli, A" uniqKey="Satelli A">A Satelli</name></author><author><name sortKey="Moridani, M" uniqKey="Moridani M">M Moridani</name></author><author><name sortKey="Jenkins, M" uniqKey="Jenkins M">M Jenkins</name></author><author><name sortKey="Rao, Us" uniqKey="Rao U">US Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Androutsopoulos, Vp" uniqKey="Androutsopoulos V">VP Androutsopoulos</name></author><author><name sortKey="Spandidos, Da" uniqKey="Spandidos D">DA Spandidos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, Cy" uniqKey="Jin C">CY Jin</name></author><author><name sortKey="Park, C" uniqKey="Park C">C Park</name></author><author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name></author><author><name sortKey="Chung, Kt" uniqKey="Chung K">KT Chung</name></author><author><name sortKey="Kwon, Tk" uniqKey="Kwon T">TK Kwon</name></author><author><name sortKey="Kim, Gy" uniqKey="Kim G">GY Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harmon, Aw" uniqKey="Harmon A">AW Harmon</name></author><author><name sortKey="Patel, Ym" uniqKey="Patel Y">YM Patel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Wolfram, J" uniqKey="Wolfram J">J Wolfram</name></author><author><name sortKey="Boom, K" uniqKey="Boom K">K Boom</name></author><author><name sortKey="Fang, X" uniqKey="Fang X">X Fang</name></author><author><name sortKey="Shen, H" uniqKey="Shen H">H Shen</name></author><author><name sortKey="Ferrari, M" uniqKey="Ferrari M">M Ferrari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pandey, M" uniqKey="Pandey M">M Pandey</name></author><author><name sortKey="Kaur, P" uniqKey="Kaur P">P Kaur</name></author><author><name sortKey="Shukla, S" uniqKey="Shukla S">S Shukla</name></author><author><name sortKey="Abbas, A" uniqKey="Abbas A">A Abbas</name></author><author><name sortKey="Fu, P" uniqKey="Fu P">P Fu</name></author><author><name sortKey="Gupta, S" uniqKey="Gupta S">S Gupta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luo, H" uniqKey="Luo H">H Luo</name></author><author><name sortKey="Jiang, B" uniqKey="Jiang B">B Jiang</name></author><author><name sortKey="Li, B" uniqKey="Li B">B Li</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author><author><name sortKey="Jiang, Bh" uniqKey="Jiang B">BH Jiang</name></author><author><name sortKey="Chen, Yc" uniqKey="Chen Y">YC Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiao, H" uniqKey="Xiao H">H Xiao</name></author><author><name sortKey="Yang, Cs" uniqKey="Yang C">CS Yang</name></author><author><name sortKey="Li, S" uniqKey="Li S">S Li</name></author><author><name sortKey="Jin, H" uniqKey="Jin H">H Jin</name></author><author><name sortKey="Ho, Ct" uniqKey="Ho C">CT Ho</name></author><author><name sortKey="Patel, T" uniqKey="Patel T">T Patel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walle, T" uniqKey="Walle T">T Walle</name></author><author><name sortKey="Ta, N" uniqKey="Ta N">N Ta</name></author><author><name sortKey="Kawamori, T" uniqKey="Kawamori T">T Kawamori</name></author><author><name sortKey="Wen, X" uniqKey="Wen X">X Wen</name></author><author><name sortKey="Tsuji, Pa" uniqKey="Tsuji P">PA Tsuji</name></author><author><name sortKey="Walle, Uk" uniqKey="Walle U">UK Walle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seibert, H" uniqKey="Seibert H">H Seibert</name></author><author><name sortKey="Maser, E" uniqKey="Maser E">E Maser</name></author><author><name sortKey="Schweda, K" uniqKey="Schweda K">K Schweda</name></author><author><name sortKey="Seibert, S" uniqKey="Seibert S">S Seibert</name></author><author><name sortKey="Gulden, M" uniqKey="Gulden M">M Gülden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iwuchukwu, Of" uniqKey="Iwuchukwu O">OF Iwuchukwu</name></author><author><name sortKey="Tallarida, Rj" uniqKey="Tallarida R">RJ Tallarida</name></author><author><name sortKey="Nagar, S" uniqKey="Nagar S">S Nagar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, F" uniqKey="Sun F">F Sun</name></author><author><name sortKey="Zheng, Xy" uniqKey="Zheng X">XY Zheng</name></author><author><name sortKey="Ye, J" uniqKey="Ye J">J Ye</name></author><author><name sortKey="Wu, Tt" uniqKey="Wu T">TT Wu</name></author><author><name sortKey="Wang, Ji" uniqKey="Wang J">JI Wang</name></author><author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodgers, Eh" uniqKey="Rodgers E">EH Rodgers</name></author><author><name sortKey="Grant, Mh" uniqKey="Grant M">MH Grant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Forni, C" uniqKey="Forni C">C Forni</name></author><author><name sortKey="Braglia, R" uniqKey="Braglia R">R Braglia</name></author><author><name sortKey="Lentini, A" uniqKey="Lentini A">A Lentini</name></author><author><name sortKey="Nuccetelli, M" uniqKey="Nuccetelli M">M Nuccetelli</name></author><author><name sortKey="Provenzano, B" uniqKey="Provenzano B">B Provenzano</name></author><author><name sortKey="Tabolacci, C" uniqKey="Tabolacci C">C Tabolacci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagao, T" uniqKey="Nagao T">T Nagao</name></author><author><name sortKey="Abe, F" uniqKey="Abe F">F Abe</name></author><author><name sortKey="Kinjo, J" uniqKey="Kinjo J">J Kinjo</name></author><author><name sortKey="Okabe, H" uniqKey="Okabe H">H Okabe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Himeji, M" uniqKey="Himeji M">M Himeji</name></author><author><name sortKey="Ohtsuki, T" uniqKey="Ohtsuki T">T Ohtsuki</name></author><author><name sortKey="Fukazawa, H" uniqKey="Fukazawa H">H Fukazawa</name></author><author><name sortKey="Tanaka, M" uniqKey="Tanaka M">M Tanaka</name></author><author><name sortKey="Yazaki, S" uniqKey="Yazaki S">S Yazaki</name></author><author><name sortKey="Ui, S" uniqKey="Ui S">S Ui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ikezoe, T" uniqKey="Ikezoe T">T Ikezoe</name></author><author><name sortKey="Chen, Ss" uniqKey="Chen S">SS Chen</name></author><author><name sortKey="Heber, D" uniqKey="Heber D">D Heber</name></author><author><name sortKey="Taguchi, H" uniqKey="Taguchi H">H Taguchi</name></author><author><name sortKey="Koeffler, Hp" uniqKey="Koeffler H">HP Koeffler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonham, M" uniqKey="Bonham M">M Bonham</name></author><author><name sortKey="Posakony, J" uniqKey="Posakony J">J Posakony</name></author><author><name sortKey="Coleman, I" uniqKey="Coleman I">I Coleman</name></author><author><name sortKey="Montgomery, B" uniqKey="Montgomery B">B Montgomery</name></author><author><name sortKey="Simon, J" uniqKey="Simon J">J Simon</name></author><author><name sortKey="Nelson, Ps" uniqKey="Nelson P">PS Nelson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, Q" uniqKey="Zheng Q">Q Zheng</name></author><author><name sortKey="Hirose, Y" uniqKey="Hirose Y">Y Hirose</name></author><author><name sortKey="Yoshimi, N" uniqKey="Yoshimi N">N Yoshimi</name></author><author><name sortKey="Murakami, A" uniqKey="Murakami A">A Murakami</name></author><author><name sortKey="Koshimizu, K" uniqKey="Koshimizu K">K Koshimizu</name></author><author><name sortKey="Ohigashi, H" uniqKey="Ohigashi H">H Ohigashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Ch" uniqKey="Chen C">CH Chen</name></author><author><name sortKey="Huang, Ll" uniqKey="Huang L">LL Huang</name></author><author><name sortKey="Huang, Cc" uniqKey="Huang C">CC Huang</name></author><author><name sortKey="Lin, Cc" uniqKey="Lin C">CC Lin</name></author><author><name sortKey="Lee, Y" uniqKey="Lee Y">Y Lee</name></author><author><name sortKey="Lu, Fj" uniqKey="Lu F">FJ Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuo, Sm" uniqKey="Kuo S">SM Kuo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, Tb" uniqKey="Hong T">TB Hong</name></author><author><name sortKey="Rahumatullah, A" uniqKey="Rahumatullah A">A Rahumatullah</name></author><author><name sortKey="Yogarajah, T" uniqKey="Yogarajah T">T Yogarajah</name></author><author><name sortKey="Ahmad, M" uniqKey="Ahmad M">M Ahmad</name></author><author><name sortKey="Yin, Kb" uniqKey="Yin K">KB Yin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Sf" uniqKey="Yang S">SF Yang</name></author><author><name sortKey="Yang, We" uniqKey="Yang W">WE Yang</name></author><author><name sortKey="Chang, Hr" uniqKey="Chang H">HR Chang</name></author><author><name sortKey="Chu, Sc" uniqKey="Chu S">SC Chu</name></author><author><name sortKey="Hsieh, Ys" uniqKey="Hsieh Y">YS Hsieh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, B" uniqKey="Wu B">B Wu</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author><author><name sortKey="Shen, W" uniqKey="Shen W">W Shen</name></author><author><name sortKey="Zhu, J" uniqKey="Zhu J">J Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patil, Jr" uniqKey="Patil J">JR Patil</name></author><author><name sortKey="Chidambara, Murthy Kn" uniqKey="Chidambara M">Murthy KN Chidambara</name></author><author><name sortKey="Jayaprakasha, Gk" uniqKey="Jayaprakasha G">GK Jayaprakasha</name></author><author><name sortKey="Chetti, Mb" uniqKey="Chetti M">MB Chetti</name></author><author><name sortKey="Patil, Bs" uniqKey="Patil B">BS Patil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Du, B" uniqKey="Du B">B Du</name></author><author><name sortKey="Wang, T" uniqKey="Wang T">T Wang</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luo, H" uniqKey="Luo H">H Luo</name></author><author><name sortKey="Rankin, Go" uniqKey="Rankin G">GO Rankin</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author><author><name sortKey="Depriest, L" uniqKey="Depriest L">L Depriest</name></author><author><name sortKey="Chen, Yc" uniqKey="Chen Y">YC Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Heideman, L" uniqKey="Heideman L">L Heideman</name></author><author><name sortKey="Chung, Cs" uniqKey="Chung C">CS Chung</name></author><author><name sortKey="Pelling, Jc" uniqKey="Pelling J">JC Pelling</name></author><author><name sortKey="Koehler, Kj" uniqKey="Koehler K">KJ Koehler</name></author><author><name sortKey="Birt, Df" uniqKey="Birt D">DF Birt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sivagami, G" uniqKey="Sivagami G">G Sivagami</name></author><author><name sortKey="Vinothkumar, R" uniqKey="Vinothkumar R">R Vinothkumar</name></author><author><name sortKey="Preethy, Cp" uniqKey="Preethy C">CP Preethy</name></author><author><name sortKey="Riyasdeen, A" uniqKey="Riyasdeen A">A Riyasdeen</name></author><author><name sortKey="Akbarsha, Ma" uniqKey="Akbarsha M">MA Akbarsha</name></author><author><name sortKey="Menon, Vp" uniqKey="Menon V">VP Menon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="You, Hj" uniqKey="You H">HJ You</name></author><author><name sortKey="Ahn, Hj" uniqKey="Ahn H">HJ Ahn</name></author><author><name sortKey="Ji, Ge" uniqKey="Ji G">GE Ji</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cai, J" uniqKey="Cai J">J Cai</name></author><author><name sortKey="Zhao, Xl" uniqKey="Zhao X">XL Zhao</name></author><author><name sortKey="Liu, Aw" uniqKey="Liu A">AW Liu</name></author><author><name sortKey="Nian, H" uniqKey="Nian H">H Nian</name></author><author><name sortKey="Zhang, Sh" uniqKey="Zhang S">SH Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, L" uniqKey="Wei L">L Wei</name></author><author><name sortKey="Lu, N" uniqKey="Lu N">N Lu</name></author><author><name sortKey="Dai, Q" uniqKey="Dai Q">Q Dai</name></author><author><name sortKey="Rong, J" uniqKey="Rong J">J Rong</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, M" uniqKey="Xu M">M Xu</name></author><author><name sortKey="Lu, N" uniqKey="Lu N">N Lu</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Dai, Q" uniqKey="Dai Q">Q Dai</name></author><author><name sortKey="Wei, L" uniqKey="Wei L">L Wei</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romanouskaya, Tv" uniqKey="Romanouskaya T">TV Romanouskaya</name></author><author><name sortKey="Grinev, Vv" uniqKey="Grinev V">VV Grinev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jang, Ky" uniqKey="Jang K">KY Jang</name></author><author><name sortKey="Jeong, Sj" uniqKey="Jeong S">SJ Jeong</name></author><author><name sortKey="Kim, Sh" uniqKey="Kim S">SH Kim</name></author><author><name sortKey="Jung, Jh" uniqKey="Jung J">JH Jung</name></author><author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name></author><author><name sortKey="Koh, W" uniqKey="Koh W">W Koh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baumann, S" uniqKey="Baumann S">S Baumann</name></author><author><name sortKey="Fas, Sc" uniqKey="Fas S">SC Fas</name></author><author><name sortKey="Giaisi, M" uniqKey="Giaisi M">M Giaisi</name></author><author><name sortKey="Muller, Ww" uniqKey="Muller W">WW Müller</name></author><author><name sortKey="Merling, A" uniqKey="Merling A">A Merling</name></author><author><name sortKey="Gulow, K" uniqKey="Gulow K">K Gülow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guthrie, N" uniqKey="Guthrie N">N Guthrie</name></author><author><name sortKey="Gapor, A" uniqKey="Gapor A">A Gapor</name></author><author><name sortKey="Chambers, Af" uniqKey="Chambers A">AF Chambers</name></author><author><name sortKey="Carroll, Kk" uniqKey="Carroll K">KK Carroll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Lm" uniqKey="Wang L">LM Wang</name></author><author><name sortKey="Xie, Kp" uniqKey="Xie K">KP Xie</name></author><author><name sortKey="Huo, Hn" uniqKey="Huo H">HN Huo</name></author><author><name sortKey="Shang, F" uniqKey="Shang F">F Shang</name></author><author><name sortKey="Zou, W" uniqKey="Zou W">W Zou</name></author><author><name sortKey="Xie, Mj" uniqKey="Xie M">MJ Xie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Mj" uniqKey="Kim M">MJ Kim</name></author><author><name sortKey="Woo, Js" uniqKey="Woo J">JS Woo</name></author><author><name sortKey="Kwon, Ch" uniqKey="Kwon C">CH Kwon</name></author><author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name></author><author><name sortKey="Kim, Yk" uniqKey="Kim Y">YK Kim</name></author><author><name sortKey="Kim, Kh" uniqKey="Kim K">KH Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Long, X" uniqKey="Long X">X Long</name></author><author><name sortKey="Fan, M" uniqKey="Fan M">M Fan</name></author><author><name sortKey="Bigsby, Rm" uniqKey="Bigsby R">RM Bigsby</name></author><author><name sortKey="Nephew, Kp" uniqKey="Nephew K">KP Nephew</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Britton, Rg" uniqKey="Britton R">RG Britton</name></author><author><name sortKey="Horner Glister, E" uniqKey="Horner Glister E">E Horner-Glister</name></author><author><name sortKey="Pomenya, Oa" uniqKey="Pomenya O">OA Pomenya</name></author><author><name sortKey="Smith, Ee" uniqKey="Smith E">EE Smith</name></author><author><name sortKey="Denton, R" uniqKey="Denton R">R Denton</name></author><author><name sortKey="Jenkins, Pr" uniqKey="Jenkins P">PR Jenkins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Jy" uniqKey="Kim J">JY Kim</name></author><author><name sortKey="Jeon, Yk" uniqKey="Jeon Y">YK Jeon</name></author><author><name sortKey="Jeon, W" uniqKey="Jeon W">W Jeon</name></author><author><name sortKey="Nam, Mj" uniqKey="Nam M">MJ Nam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khan, N" uniqKey="Khan N">N Khan</name></author><author><name sortKey="Asim, M" uniqKey="Asim M">M Asim</name></author><author><name sortKey="Afaq, F" uniqKey="Afaq F">F Afaq</name></author><author><name sortKey="Abu Zaid, M" uniqKey="Abu Zaid M">M Abu Zaid</name></author><author><name sortKey="Mukhtar, H" uniqKey="Mukhtar H">H Mukhtar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seo, Yj" uniqKey="Seo Y">YJ Seo</name></author><author><name sortKey="Kim, Bs" uniqKey="Kim B">BS Kim</name></author><author><name sortKey="Chun, Sy" uniqKey="Chun S">SY Chun</name></author><author><name sortKey="Park, Yk" uniqKey="Park Y">YK Park</name></author><author><name sortKey="Kang, Ks" uniqKey="Kang K">KS Kang</name></author><author><name sortKey="Kwon, Tg" uniqKey="Kwon T">TG Kwon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name></author><author><name sortKey="Ruan, Q" uniqKey="Ruan Q">Q Ruan</name></author><author><name sortKey="Bedner, E" uniqKey="Bedner E">E Bedner</name></author><author><name sortKey="Deptala, A" uniqKey="Deptala A">A Deptala</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Hsieh, Tc" uniqKey="Hsieh T">TC Hsieh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pan, Mh" uniqKey="Pan M">MH Pan</name></author><author><name sortKey="Chen, Wj" uniqKey="Chen W">WJ Chen</name></author><author><name sortKey="Lin Shiau, Sy" uniqKey="Lin Shiau S">SY Lin-Shiau</name></author><author><name sortKey="Ho, Ct" uniqKey="Ho C">CT Ho</name></author><author><name sortKey="Lin, Jk" uniqKey="Lin J">JK Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name></author><author><name sortKey="Liu, Rh" uniqKey="Liu R">RH Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parajuli, P" uniqKey="Parajuli P">P Parajuli</name></author><author><name sortKey="Joshee, N" uniqKey="Joshee N">N Joshee</name></author><author><name sortKey="Rimando, Am" uniqKey="Rimando A">AM Rimando</name></author><author><name sortKey="Mittal, S" uniqKey="Mittal S">S Mittal</name></author><author><name sortKey="Yadav, Ak" uniqKey="Yadav A">AK Yadav</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skupie, K" uniqKey="Skupie K">K Skupień</name></author><author><name sortKey="Oszmia Ski, J" uniqKey="Oszmia Ski J">J Oszmiański</name></author><author><name sortKey="Kostrzewa Nowak, D" uniqKey="Kostrzewa Nowak D">D Kostrzewa-Nowak</name></author><author><name sortKey="Tarasiuk, J" uniqKey="Tarasiuk J">J Tarasiuk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, Hf" uniqKey="Lu H">HF Lu</name></author><author><name sortKey="Chie, Yj" uniqKey="Chie Y">YJ Chie</name></author><author><name sortKey="Yang, Ms" uniqKey="Yang M">MS Yang</name></author><author><name sortKey="Lee, Cs" uniqKey="Lee C">CS Lee</name></author><author><name sortKey="Fu, Jj" uniqKey="Fu J">JJ Fu</name></author><author><name sortKey="Yang, Js" uniqKey="Yang J">JS Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Wy" uniqKey="Chen W">WY Chen</name></author><author><name sortKey="Hsieh, Ya" uniqKey="Hsieh Y">YA Hsieh</name></author><author><name sortKey="Tsai, Ci" uniqKey="Tsai C">CI Tsai</name></author><author><name sortKey="Kang, Yf" uniqKey="Kang Y">YF Kang</name></author><author><name sortKey="Chang, Fr" uniqKey="Chang F">FR Chang</name></author><author><name sortKey="Wu, Yc" uniqKey="Wu Y">YC Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Strouch, Mj" uniqKey="Strouch M">MJ Strouch</name></author><author><name sortKey="Milam, Bm" uniqKey="Milam B">BM Milam</name></author><author><name sortKey="Melstrom, Lg" uniqKey="Melstrom L">LG Melstrom</name></author><author><name sortKey="Mcgill, Jj" uniqKey="Mcgill J">JJ McGill</name></author><author><name sortKey="Salabat, Mr" uniqKey="Salabat M">MR Salabat</name></author><author><name sortKey="Ujiki, Mb" uniqKey="Ujiki M">MB Ujiki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sak, K" uniqKey="Sak K">K Sak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suh, Y" uniqKey="Suh Y">Y Suh</name></author><author><name sortKey="Afaq, F" uniqKey="Afaq F">F Afaq</name></author><author><name sortKey="Johnson, Jj" uniqKey="Johnson J">JJ Johnson</name></author><author><name sortKey="Mukhtar, H" uniqKey="Mukhtar H">H Mukhtar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Syed, Dn" uniqKey="Syed D">DN Syed</name></author><author><name sortKey="Afaq, F" uniqKey="Afaq F">F Afaq</name></author><author><name sortKey="Maddodi, N" uniqKey="Maddodi N">N Maddodi</name></author><author><name sortKey="Johnson, Jj" uniqKey="Johnson J">JJ Johnson</name></author><author><name sortKey="Sarfaraz, S" uniqKey="Sarfaraz S">S Sarfaraz</name></author><author><name sortKey="Ahmad, A" uniqKey="Ahmad A">A Ahmad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lim Do, Y" uniqKey="Lim Do Y">Y Lim do</name></author><author><name sortKey="Park, Jh" uniqKey="Park J">JH Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khan, N" uniqKey="Khan N">N Khan</name></author><author><name sortKey="Afaq, F" uniqKey="Afaq F">F Afaq</name></author><author><name sortKey="Khusro, Fh" uniqKey="Khusro F">FH Khusro</name></author><author><name sortKey="Mustafa, Adhami V" uniqKey="Mustafa A">Adhami V Mustafa</name></author><author><name sortKey="Suh, Y" uniqKey="Suh Y">Y Suh</name></author><author><name sortKey="Mukhtar, H" uniqKey="Mukhtar H">H Mukhtar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khan, N" uniqKey="Khan N">N Khan</name></author><author><name sortKey="Afaq, F" uniqKey="Afaq F">F Afaq</name></author><author><name sortKey="Syed, Dn" uniqKey="Syed D">DN Syed</name></author><author><name sortKey="Mukhtar, H" uniqKey="Mukhtar H">H Mukhtar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haddad, Aq" uniqKey="Haddad A">AQ Haddad</name></author><author><name sortKey="Fleshner, N" uniqKey="Fleshner N">N Fleshner</name></author><author><name sortKey="Nelson, C" uniqKey="Nelson C">C Nelson</name></author><author><name sortKey="Saour, B" uniqKey="Saour B">B Saour</name></author><author><name sortKey="Musquera, M" uniqKey="Musquera M">M Musquera</name></author><author><name sortKey="Venkateswaran, V" uniqKey="Venkateswaran V">V Venkateswaran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Lan, Y" uniqKey="Lan Y">Y Lan</name></author><author><name sortKey="Huang, Q" uniqKey="Huang Q">Q Huang</name></author><author><name sortKey="Hua, Z" uniqKey="Hua Z">Z Hua</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murray, Tj" uniqKey="Murray T">TJ Murray</name></author><author><name sortKey="Yang, X" uniqKey="Yang X">X Yang</name></author><author><name sortKey="Sherr, Dh" uniqKey="Sherr D">DH Sherr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hernandez, J" uniqKey="Hernandez J">J Hernandez</name></author><author><name sortKey="Goycoolea, Fm" uniqKey="Goycoolea F">FM Goycoolea</name></author><author><name sortKey="Quintero, J" uniqKey="Quintero J">J Quintero</name></author><author><name sortKey="Acosta, A" uniqKey="Acosta A">A Acosta</name></author><author><name sortKey="Castaneda, M" uniqKey="Castaneda M">M Castaneda</name></author><author><name sortKey="Dominguez, Z" uniqKey="Dominguez Z">Z Dominguez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bestwick, Cs" uniqKey="Bestwick C">CS Bestwick</name></author><author><name sortKey="Milne, L" uniqKey="Milne L">L Milne</name></author><author><name sortKey="Duthie, Sj" uniqKey="Duthie S">SJ Duthie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ackland, Ml" uniqKey="Ackland M">ML Ackland</name></author><author><name sortKey="Van De Waarsenburg, S" uniqKey="Van De Waarsenburg S">S van de Waarsenburg</name></author><author><name sortKey="Jones, R" uniqKey="Jones R">R Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fabjan, N" uniqKey="Fabjan N">N Fabjan</name></author><author><name sortKey="Rode, J" uniqKey="Rode J">J Rode</name></author><author><name sortKey="Kosir, Ij" uniqKey="Kosir I">IJ Kosir</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name></author><author><name sortKey="Kreft, I" uniqKey="Kreft I">I Kreft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="M Mmel, P" uniqKey="M Mmel P">P Mämmelä</name></author><author><name sortKey="Savolainen, H" uniqKey="Savolainen H">H Savolainen</name></author><author><name sortKey="Lindroos, L" uniqKey="Lindroos L">L Lindroos</name></author><author><name sortKey="Kangas, J" uniqKey="Kangas J">J Kangas</name></author><author><name sortKey="Vartiainen, T" uniqKey="Vartiainen T">T Vartiainen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name></author><author><name sortKey="Qian, D" uniqKey="Qian D">D Qian</name></author><author><name sortKey="Guo, J" uniqKey="Guo J">J Guo</name></author><author><name sortKey="Shang, Ex" uniqKey="Shang E">EX Shang</name></author><author><name sortKey="Duan, Ja" uniqKey="Duan J">JA Duan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thani, W" uniqKey="Thani W">W Thani</name></author><author><name sortKey="Vallisuta, O" uniqKey="Vallisuta O">O Vallisuta</name></author><author><name sortKey="Siripong, P" uniqKey="Siripong P">P Siripong</name></author><author><name sortKey="Ruangwises, N" uniqKey="Ruangwises N">N Ruangwises</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Er" uniqKey="Lee E">ER Lee</name></author><author><name sortKey="Kang, Yj" uniqKey="Kang Y">YJ Kang</name></author><author><name sortKey="Kim, Hj" uniqKey="Kim H">HJ Kim</name></author><author><name sortKey="Choi, Hy" uniqKey="Choi H">HY Choi</name></author><author><name sortKey="Kang, Gh" uniqKey="Kang G">GH Kang</name></author><author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frydoonfar, Hr" uniqKey="Frydoonfar H">HR Frydoonfar</name></author><author><name sortKey="Mcgrath, Dr" uniqKey="Mcgrath D">DR McGrath</name></author><author><name sortKey="Spigelman, Ad" uniqKey="Spigelman A">AD Spigelman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alshatwi, Aa" uniqKey="Alshatwi A">AA Alshatwi</name></author><author><name sortKey="Hasan, Tn" uniqKey="Hasan T">TN Hasan</name></author><author><name sortKey="Shafi, G" uniqKey="Shafi G">G Shafi</name></author><author><name sortKey="Alsaif, Ma" uniqKey="Alsaif M">MA Alsaif</name></author><author><name sortKey="Al Hazzani, Aa" uniqKey="Al Hazzani A">AA Al-Hazzani</name></author><author><name sortKey="Alsaif, Aa" uniqKey="Alsaif A">AA Alsaif</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zarebczan, B" uniqKey="Zarebczan B">B Zarebczan</name></author><author><name sortKey="Pinchot, Sn" uniqKey="Pinchot S">SN Pinchot</name></author><author><name sortKey="Kunnimalaiyaan, M" uniqKey="Kunnimalaiyaan M">M Kunnimalaiyaan</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quintin, J" uniqKey="Quintin J">J Quintin</name></author><author><name sortKey="Buisson, D" uniqKey="Buisson D">D Buisson</name></author><author><name sortKey="Thoret, S" uniqKey="Thoret S">S Thoret</name></author><author><name sortKey="Cresteil, T" uniqKey="Cresteil T">T Cresteil</name></author><author><name sortKey="Lewin, G" uniqKey="Lewin G">G Lewin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pereira, Rm" uniqKey="Pereira R">RM Pereira</name></author><author><name sortKey="Andrades, Ne" uniqKey="Andrades N">NE Andrades</name></author><author><name sortKey="Paulino, N" uniqKey="Paulino N">N Paulino</name></author><author><name sortKey="Sawaya, Ac" uniqKey="Sawaya A">AC Sawaya</name></author><author><name sortKey="Eberlin, Mn" uniqKey="Eberlin M">MN Eberlin</name></author><author><name sortKey="Marcucci, Mc" uniqKey="Marcucci M">MC Marcucci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zandi, K" uniqKey="Zandi K">K Zandi</name></author><author><name sortKey="Teoh, Bt" uniqKey="Teoh B">BT Teoh</name></author><author><name sortKey="Sam, Ss" uniqKey="Sam S">SS Sam</name></author><author><name sortKey="Wong, Pf" uniqKey="Wong P">PF Wong</name></author><author><name sortKey="Mustafa, Mr" uniqKey="Mustafa M">MR Mustafa</name></author><author><name sortKey="Abubakar, S" uniqKey="Abubakar S">S Abubakar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wesolowska, O" uniqKey="Wesolowska O">O Wesolowska</name></author><author><name sortKey="Wisniewski, J" uniqKey="Wisniewski J">J Wisniewski</name></author><author><name sortKey="Sroda Pomianek, K" uniqKey="Sroda Pomianek K">K Sroda-Pomianek</name></author><author><name sortKey="Bielawska Pohl, A" uniqKey="Bielawska Pohl A">A Bielawska-Pohl</name></author><author><name sortKey="Paprocka, M" uniqKey="Paprocka M">M Paprocka</name></author><author><name sortKey="Du, D" uniqKey="Du D">D Duś</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nazari, M" uniqKey="Nazari M">M Nazari</name></author><author><name sortKey="Ghorbani, A" uniqKey="Ghorbani A">A Ghorbani</name></author><author><name sortKey="Hekmat Doost, A" uniqKey="Hekmat Doost A">A Hekmat-Doost</name></author><author><name sortKey="Jeddi Tehrani, M" uniqKey="Jeddi Tehrani M">M Jeddi-Tehrani</name></author><author><name sortKey="Zand, H" uniqKey="Zand H">H Zand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Ashaal, Ha" uniqKey="Al Ashaal H">HA Al-Ashaal</name></author><author><name sortKey="El Sheltawy, St" uniqKey="El Sheltawy S">ST El-Sheltawy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Wj" uniqKey="Lee W">WJ Lee</name></author><author><name sortKey="Chen, Wk" uniqKey="Chen W">WK Chen</name></author><author><name sortKey="Wang, Cj" uniqKey="Wang C">CJ Wang</name></author><author><name sortKey="Lin, Wl" uniqKey="Lin W">WL Lin</name></author><author><name sortKey="Tseng, Th" uniqKey="Tseng T">TH Tseng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gupta, S" uniqKey="Gupta S">S Gupta</name></author><author><name sortKey="Afaq, F" uniqKey="Afaq F">F Afaq</name></author><author><name sortKey="Mukhtar, H" uniqKey="Mukhtar H">H Mukhtar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, Si" uniqKey="Choi S">SI Choi</name></author><author><name sortKey="Jeong, Cs" uniqKey="Jeong C">CS Jeong</name></author><author><name sortKey="Cho, Sy" uniqKey="Cho S">SY Cho</name></author><author><name sortKey="Lee, Ys" uniqKey="Lee Y">YS Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mak, P" uniqKey="Mak P">P Mak</name></author><author><name sortKey="Leung, Yk" uniqKey="Leung Y">YK Leung</name></author><author><name sortKey="Tang, Wy" uniqKey="Tang W">WY Tang</name></author><author><name sortKey="Harwood, C" uniqKey="Harwood C">C Harwood</name></author><author><name sortKey="Ho, Sm" uniqKey="Ho S">SM Ho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, Hf" uniqKey="Lu H">HF Lu</name></author><author><name sortKey="Chie, Yj" uniqKey="Chie Y">YJ Chie</name></author><author><name sortKey="Yang, Ms" uniqKey="Yang M">MS Yang</name></author><author><name sortKey="Lu, Kw" uniqKey="Lu K">KW Lu</name></author><author><name sortKey="Fu, Jj" uniqKey="Fu J">JJ Fu</name></author><author><name sortKey="Yang, Js" uniqKey="Yang J">JS Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, B" uniqKey="Wu B">B Wu</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Huang, D" uniqKey="Huang D">D Huang</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Liao, Y" uniqKey="Liao Y">Y Liao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Dy" uniqKey="Zhang D">DY Zhang</name></author><author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name></author><author><name sortKey="Ye, F" uniqKey="Ye F">F Ye</name></author><author><name sortKey="Xue, L" uniqKey="Xue L">L Xue</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Yi, J" uniqKey="Yi J">J Yi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Qb" uniqKey="Li Q">QB Li</name></author><author><name sortKey="You, Y" uniqKey="You Y">Y You</name></author><author><name sortKey="Chen, Zc" uniqKey="Chen Z">ZC Chen</name></author><author><name sortKey="Lu, J" uniqKey="Lu J">J Lü</name></author><author><name sortKey="Shao, J" uniqKey="Shao J">J Shao</name></author><author><name sortKey="Zou, P" uniqKey="Zou P">P Zou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chou, Ds" uniqKey="Chou D">DS Chou</name></author><author><name sortKey="Hsiao, G" uniqKey="Hsiao G">G Hsiao</name></author><author><name sortKey="Lai, Ya" uniqKey="Lai Y">YA Lai</name></author><author><name sortKey="Tsai, Yj" uniqKey="Tsai Y">YJ Tsai</name></author><author><name sortKey="Sheu, Jr" uniqKey="Sheu J">JR Sheu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weng, Ms" uniqKey="Weng M">MS Weng</name></author><author><name sortKey="Ho, Ys" uniqKey="Ho Y">YS Ho</name></author><author><name sortKey="Lin, Jk" uniqKey="Lin J">JK Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pichichero, E" uniqKey="Pichichero E">E Pichichero</name></author><author><name sortKey="Cicconi, R" uniqKey="Cicconi R">R Cicconi</name></author><author><name sortKey="Mattei, M" uniqKey="Mattei M">M Mattei</name></author><author><name sortKey="Muzi, Mg" uniqKey="Muzi M">MG Muzi</name></author><author><name sortKey="Canini, A" uniqKey="Canini A">A Canini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, J" uniqKey="Ren J">J Ren</name></author><author><name sortKey="Cheng, H" uniqKey="Cheng H">H Cheng</name></author><author><name sortKey="Xin, Wq" uniqKey="Xin W">WQ Xin</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Hu, K" uniqKey="Hu K">K Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsui, Kh" uniqKey="Tsui K">KH Tsui</name></author><author><name sortKey="Chung, Lc" uniqKey="Chung L">LC Chung</name></author><author><name sortKey="Feng, Th" uniqKey="Feng T">TH Feng</name></author><author><name sortKey="Chang, Pl" uniqKey="Chang P">PL Chang</name></author><author><name sortKey="Juang, Hh" uniqKey="Juang H">HH Juang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Kh" uniqKey="Chen K">KH Chen</name></author><author><name sortKey="Weng, Ms" uniqKey="Weng M">MS Weng</name></author><author><name sortKey="Lin, Jk" uniqKey="Lin J">JK Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, M" uniqKey="Zhang M">M Zhang</name></author><author><name sortKey="Liu, Lp" uniqKey="Liu L">LP Liu</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Tian, Xy" uniqKey="Tian X">XY Tian</name></author><author><name sortKey="Qin, J" uniqKey="Qin J">J Qin</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ciesielska, E" uniqKey="Ciesielska E">E Ciesielska</name></author><author><name sortKey="Gwardys, A" uniqKey="Gwardys A">A Gwardys</name></author><author><name sortKey="Metodiewa, D" uniqKey="Metodiewa D">D Metodiewa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name></author><author><name sortKey="Tang, Lj" uniqKey="Tang L">LJ Tang</name></author><author><name sortKey="Zhu, Gq" uniqKey="Zhu G">GQ Zhu</name></author><author><name sortKey="Peng, Dy" uniqKey="Peng D">DY Peng</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Sun, Fn" uniqKey="Sun F">FN Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chowdhury, Sa" uniqKey="Chowdhury S">SA Chowdhury</name></author><author><name sortKey="Kishino, K" uniqKey="Kishino K">K Kishino</name></author><author><name sortKey="Satoh, R" uniqKey="Satoh R">R Satoh</name></author><author><name sortKey="Hashimoto, K" uniqKey="Hashimoto K">K Hashimoto</name></author><author><name sortKey="Kikuchi, H" uniqKey="Kikuchi H">H Kikuchi</name></author><author><name sortKey="Nishikawa, H" uniqKey="Nishikawa H">H Nishikawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katalini, M" uniqKey="Katalini M">M Katalinić</name></author><author><name sortKey="Rusak, G" uniqKey="Rusak G">G Rusak</name></author><author><name sortKey="Doma Inovi Barovi, J" uniqKey="Doma Inovi Barovi J">J Domaćinović Barović</name></author><author><name sortKey="Sinko, G" uniqKey="Sinko G">G Sinko</name></author><author><name sortKey="Jeli, D" uniqKey="Jeli D">D Jelić</name></author><author><name sortKey="Antolovi, R" uniqKey="Antolovi R">R Antolović</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monasterio, A" uniqKey="Monasterio A">A Monasterio</name></author><author><name sortKey="Urdaci, Mc" uniqKey="Urdaci M">MC Urdaci</name></author><author><name sortKey="Pinchuk, Iv" uniqKey="Pinchuk I">IV Pinchuk</name></author><author><name sortKey="Lopez Moratalla, N" uniqKey="Lopez Moratalla N">N Lopez-Moratalla</name></author><author><name sortKey="Martinez Irujo, Jj" uniqKey="Martinez Irujo J">JJ Martinez-Irujo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richter, M" uniqKey="Richter M">M Richter</name></author><author><name sortKey="Ebermann, R" uniqKey="Ebermann R">R Ebermann</name></author><author><name sortKey="Marian, B" uniqKey="Marian B">B Marian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuntz, S" uniqKey="Kuntz S">S Kuntz</name></author><author><name sortKey="Wenzel, U" uniqKey="Wenzel U">U Wenzel</name></author><author><name sortKey="Daniel, H" uniqKey="Daniel H">H Daniel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Sw" uniqKey="Lee S">SW Lee</name></author><author><name sortKey="Lee, Jt" uniqKey="Lee J">JT Lee</name></author><author><name sortKey="Lee, Mg" uniqKey="Lee M">MG Lee</name></author><author><name sortKey="Lee, Hw" uniqKey="Lee H">HW Lee</name></author><author><name sortKey="Ahn, Sj" uniqKey="Ahn S">SJ Ahn</name></author><author><name sortKey="Lee, Yj" uniqKey="Lee Y">YJ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Dh" uniqKey="Kim D">DH Kim</name></author><author><name sortKey="Lee, Jt" uniqKey="Lee J">JT Lee</name></author><author><name sortKey="Lee, Ik" uniqKey="Lee I">IK Lee</name></author><author><name sortKey="Ha, Jh" uniqKey="Ha J">JH Ha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murtaza, I" uniqKey="Murtaza I">I Murtaza</name></author><author><name sortKey="Adhami, Vm" uniqKey="Adhami V">VM Adhami</name></author><author><name sortKey="Hafeez, Bb" uniqKey="Hafeez B">BB Hafeez</name></author><author><name sortKey="Saleem, M" uniqKey="Saleem M">M Saleem</name></author><author><name sortKey="Mukhtar, H" uniqKey="Mukhtar H">H Mukhtar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haddad, Aq" uniqKey="Haddad A">AQ Haddad</name></author><author><name sortKey="Venkateswaran, V" uniqKey="Venkateswaran V">V Venkateswaran</name></author><author><name sortKey="Viswanathan, L" uniqKey="Viswanathan L">L Viswanathan</name></author><author><name sortKey="Teahan, Sj" uniqKey="Teahan S">SJ Teahan</name></author><author><name sortKey="Fleshner, Ne" uniqKey="Fleshner N">NE Fleshner</name></author><author><name sortKey="Klotz, Lh" uniqKey="Klotz L">LH Klotz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ludwiczuk, A" uniqKey="Ludwiczuk A">A Ludwiczuk</name></author><author><name sortKey="Saha, A" uniqKey="Saha A">A Saha</name></author><author><name sortKey="Kuzuhara, T" uniqKey="Kuzuhara T">T Kuzuhara</name></author><author><name sortKey="Asakawa, Y" uniqKey="Asakawa Y">Y Asakawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, J" uniqKey="Brown J">J Brown</name></author><author><name sortKey="O Rey, J" uniqKey="O Rey J">J O’Prey</name></author><author><name sortKey="Harrison, Pr" uniqKey="Harrison P">PR Harrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author><author><name sortKey="Awale, S" uniqKey="Awale S">S Awale</name></author><author><name sortKey="Tezuka, Y" uniqKey="Tezuka Y">Y Tezuka</name></author><author><name sortKey="Esumi, H" uniqKey="Esumi H">H Esumi</name></author><author><name sortKey="Kadota, S" uniqKey="Kadota S">S Kadota</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bai, N" uniqKey="Bai N">N Bai</name></author><author><name sortKey="He, K" uniqKey="He K">K He</name></author><author><name sortKey="Roller, M" uniqKey="Roller M">M Roller</name></author><author><name sortKey="Lai, Cs" uniqKey="Lai C">CS Lai</name></author><author><name sortKey="Shao, X" uniqKey="Shao X">X Shao</name></author><author><name sortKey="Pan, Mh" uniqKey="Pan M">MH Pan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dickancaite, E" uniqKey="Dickancaite E">E Dickancaité</name></author><author><name sortKey="Nemeikaite, A" uniqKey="Nemeikaite A">A Nemeikaitè</name></author><author><name sortKey="Kalvelyte, A" uniqKey="Kalvelyte A">A Kalvelytè</name></author><author><name sortKey="Cenas, N" uniqKey="Cenas N">N Cènas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, Cm" uniqKey="Lin C">CM Lin</name></author><author><name sortKey="Chen, Ct" uniqKey="Chen C">CT Chen</name></author><author><name sortKey="Lee, Hh" uniqKey="Lee H">HH Lee</name></author><author><name sortKey="Lin, Jk" uniqKey="Lin J">JK Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rusak, G" uniqKey="Rusak G">G Rusak</name></author><author><name sortKey="Gutzeit, Ho" uniqKey="Gutzeit H">HO Gutzeit</name></author><author><name sortKey="Muller, Jl" uniqKey="Muller J">JL Müller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rao, Yk" uniqKey="Rao Y">YK Rao</name></author><author><name sortKey="Geethangili, M" uniqKey="Geethangili M">M Geethangili</name></author><author><name sortKey="Fang, Sh" uniqKey="Fang S">SH Fang</name></author><author><name sortKey="Tzeng, Ym" uniqKey="Tzeng Y">YM Tzeng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bigovi, D" uniqKey="Bigovi D">D Bigović</name></author><author><name sortKey="Savikin, K" uniqKey="Savikin K">K Savikin</name></author><author><name sortKey="Jankovi, T" uniqKey="Jankovi T">T Janković</name></author><author><name sortKey="Menkovi, N" uniqKey="Menkovi N">N Menković</name></author><author><name sortKey="Zduni, G" uniqKey="Zduni G">G Zdunić</name></author><author><name sortKey="Stanojkovi, T" uniqKey="Stanojkovi T">T Stanojković</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Ww" uniqKey="Huang W">WW Huang</name></author><author><name sortKey="Chiu, Yj" uniqKey="Chiu Y">YJ Chiu</name></author><author><name sortKey="Fan, Mj" uniqKey="Fan M">MJ Fan</name></author><author><name sortKey="Lu, Hf" uniqKey="Lu H">HF Lu</name></author><author><name sortKey="Yeh, Hf" uniqKey="Yeh H">HF Yeh</name></author><author><name sortKey="Li, Kh" uniqKey="Li K">KH Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name></author><author><name sortKey="Kurzer, Ms" uniqKey="Kurzer M">MS Kurzer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Balabhadrapathruni, S" uniqKey="Balabhadrapathruni S">S Balabhadrapathruni</name></author><author><name sortKey="Thomas, Tj" uniqKey="Thomas T">TJ Thomas</name></author><author><name sortKey="Yurkow, Ej" uniqKey="Yurkow E">EJ Yurkow</name></author><author><name sortKey="Amenta, Ps" uniqKey="Amenta P">PS Amenta</name></author><author><name sortKey="Thomas, T" uniqKey="Thomas T">T Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phromnoi, K" uniqKey="Phromnoi K">K Phromnoi</name></author><author><name sortKey="Yodkeeree, S" uniqKey="Yodkeeree S">S Yodkeeree</name></author><author><name sortKey="Anuchapreeda, S" uniqKey="Anuchapreeda S">S Anuchapreeda</name></author><author><name sortKey="Limtrakul, P" uniqKey="Limtrakul P">P Limtrakul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manthey, Ja" uniqKey="Manthey J">JA Manthey</name></author><author><name sortKey="Guthrie, N" uniqKey="Guthrie N">N Guthrie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loizzo, Mr" uniqKey="Loizzo M">MR Loizzo</name></author><author><name sortKey="Said, A" uniqKey="Said A">A Said</name></author><author><name sortKey="Tundis, R" uniqKey="Tundis R">R Tundis</name></author><author><name sortKey="Hawas, Uw" uniqKey="Hawas U">UW Hawas</name></author><author><name sortKey="Rashed, K" uniqKey="Rashed K">K Rashed</name></author><author><name sortKey="Menichini, F" uniqKey="Menichini F">F Menichini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Yk" uniqKey="Kim Y">YK Kim</name></author><author><name sortKey="Kim, Ys" uniqKey="Kim Y">YS Kim</name></author><author><name sortKey="Choi, Su" uniqKey="Choi S">SU Choi</name></author><author><name sortKey="Ryu, Sy" uniqKey="Ryu S">SY Ryu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kwak, Jh" uniqKey="Kwak J">JH Kwak</name></author><author><name sortKey="Kang, Mw" uniqKey="Kang M">MW Kang</name></author><author><name sortKey="Roh, Jh" uniqKey="Roh J">JH Roh</name></author><author><name sortKey="Choi, Su" uniqKey="Choi S">SU Choi</name></author><author><name sortKey="Zee, Op" uniqKey="Zee O">OP Zee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loa, J" uniqKey="Loa J">J Loa</name></author><author><name sortKey="Chow, P" uniqKey="Chow P">P Chow</name></author><author><name sortKey="Zhang, K" uniqKey="Zhang K">K Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Said, A" uniqKey="Said A">A Said</name></author><author><name sortKey="Tundis, R" uniqKey="Tundis R">R Tundis</name></author><author><name sortKey="Hawas, Uw" uniqKey="Hawas U">UW Hawas</name></author><author><name sortKey="El Kousy, Sm" uniqKey="El Kousy S">SM El-Kousy</name></author><author><name sortKey="Rashed, K" uniqKey="Rashed K">K Rashed</name></author><author><name sortKey="Menichini, F" uniqKey="Menichini F">F Menichini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nguyen, Tt" uniqKey="Nguyen T">TT Nguyen</name></author><author><name sortKey="Tran, E" uniqKey="Tran E">E Tran</name></author><author><name sortKey="Ong, Ck" uniqKey="Ong C">CK Ong</name></author><author><name sortKey="Lee, Sk" uniqKey="Lee S">SK Lee</name></author><author><name sortKey="Do, Pt" uniqKey="Do P">PT Do</name></author><author><name sortKey="Huynh, Tt" uniqKey="Huynh T">TT Huynh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Casagrande, F" uniqKey="Casagrande F">F Casagrande</name></author><author><name sortKey="Darbon, Jm" uniqKey="Darbon J">JM Darbon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Rey, J" uniqKey="O Rey J">J O’Prey</name></author><author><name sortKey="Brown, J" uniqKey="Brown J">J Brown</name></author><author><name sortKey="Fleming, J" uniqKey="Fleming J">J Fleming</name></author><author><name sortKey="Harrison, Pr" uniqKey="Harrison P">PR Harrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author><author><name sortKey="Zhao, Xh" uniqKey="Zhao X">XH Zhao</name></author><author><name sortKey="Wang, Zj" uniqKey="Wang Z">ZJ Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author><author><name sortKey="Zhao, Xh" uniqKey="Zhao X">XH Zhao</name></author><author><name sortKey="Wang, Zj" uniqKey="Wang Z">ZJ Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawaii, S" uniqKey="Kawaii S">S Kawaii</name></author><author><name sortKey="Tomono, Y" uniqKey="Tomono Y">Y Tomono</name></author><author><name sortKey="Katase, E" uniqKey="Katase E">E Katase</name></author><author><name sortKey="Ogawa, K" uniqKey="Ogawa K">K Ogawa</name></author><author><name sortKey="Yano, M" uniqKey="Yano M">M Yano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freire, Ac" uniqKey="Freire A">AC Freire</name></author><author><name sortKey="Da Silva Melo, P" uniqKey="Da Silva Melo P">P da Silva Melo</name></author><author><name sortKey="Aoyama, H" uniqKey="Aoyama H">H Aoyama</name></author><author><name sortKey="Haun, M" uniqKey="Haun M">M Haun</name></author><author><name sortKey="Duran, N" uniqKey="Duran N">N Durán</name></author><author><name sortKey="Ferreira, Cv" uniqKey="Ferreira C">CV Ferreira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aherne, Sa" uniqKey="Aherne S">SA Aherne</name></author><author><name sortKey="O Rien, Nm" uniqKey="O Rien N">NM O’Brien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Newell, Am" uniqKey="Newell A">AM Newell</name></author><author><name sortKey="Yousef, Gg" uniqKey="Yousef G">GG Yousef</name></author><author><name sortKey="Lila, Ma" uniqKey="Lila M">MA Lila</name></author><author><name sortKey="Ramirez Mares, Mv" uniqKey="Ramirez Mares M">MV Ramirez-Mares</name></author><author><name sortKey="De Mejia, Eg" uniqKey="De Mejia E">EG de Mejia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ya Ez, J" uniqKey="Ya Ez J">J Yáñez</name></author><author><name sortKey="Vicente, V" uniqKey="Vicente V">V Vicente</name></author><author><name sortKey="Alcaraz, M" uniqKey="Alcaraz M">M Alcaraz</name></author><author><name sortKey="Castillo, J" uniqKey="Castillo J">J Castillo</name></author><author><name sortKey="Benavente Garcia, O" uniqKey="Benavente Garcia O">O Benavente-García</name></author><author><name sortKey="Canteras, M" uniqKey="Canteras M">M Canteras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, R" uniqKey="Xu R">R Xu</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Ye, X" uniqKey="Ye X">X Ye</name></author><author><name sortKey="Xue, S" uniqKey="Xue S">S Xue</name></author><author><name sortKey="Shi, J" uniqKey="Shi J">J Shi</name></author><author><name sortKey="Pan, J" uniqKey="Pan J">J Pan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lohezic Le Dehevat, F" uniqKey="Lohezic Le Dehevat F">F Lohezic-Le Dehevat</name></author><author><name sortKey="Tomasi, S" uniqKey="Tomasi S">S Tomasi</name></author><author><name sortKey="Fontanel, D" uniqKey="Fontanel D">D Fontanel</name></author><author><name sortKey="Boustie, J" uniqKey="Boustie J">J Boustie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simirgiotis, Mj" uniqKey="Simirgiotis M">MJ Simirgiotis</name></author><author><name sortKey="Adachi, S" uniqKey="Adachi S">S Adachi</name></author><author><name sortKey="To, S" uniqKey="To S">S To</name></author><author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name></author><author><name sortKey="Reynertson, Ka" uniqKey="Reynertson K">KA Reynertson</name></author><author><name sortKey="Basile, Mj" uniqKey="Basile M">MJ Basile</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Browning, Am" uniqKey="Browning A">AM Browning</name></author><author><name sortKey="Walle, Uk" uniqKey="Walle U">UK Walle</name></author><author><name sortKey="Walle, T" uniqKey="Walle T">T Walle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chao, Ji" uniqKey="Chao J">JI Chao</name></author><author><name sortKey="Su, Wc" uniqKey="Su W">WC Su</name></author><author><name sortKey="Liu, Hf" uniqKey="Liu H">HF Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramanathan, R" uniqKey="Ramanathan R">R Ramanathan</name></author><author><name sortKey="Tan, Ch" uniqKey="Tan C">CH Tan</name></author><author><name sortKey="Das, Np" uniqKey="Das N">NP Das</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Yh" uniqKey="Chen Y">YH Chen</name></author><author><name sortKey="Chen, Hy" uniqKey="Chen H">HY Chen</name></author><author><name sortKey="Hsu, Cl" uniqKey="Hsu C">CL Hsu</name></author><author><name sortKey="Yen, Gc" uniqKey="Yen G">GC Yen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rhouma, Gb" uniqKey="Rhouma G">GB Rhouma</name></author><author><name sortKey="Chebil, L" uniqKey="Chebil L">L Chebil</name></author><author><name sortKey="Mustapha, N" uniqKey="Mustapha N">N Mustapha</name></author><author><name sortKey="Krifa, M" uniqKey="Krifa M">M Krifa</name></author><author><name sortKey="Ghedira, K" uniqKey="Ghedira K">K Ghedira</name></author><author><name sortKey="Ghoul, M" uniqKey="Ghoul M">M Ghoul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goniotaki, M" uniqKey="Goniotaki M">M Goniotaki</name></author><author><name sortKey="Hatziantoniou, S" uniqKey="Hatziantoniou S">S Hatziantoniou</name></author><author><name sortKey="Dimas, K" uniqKey="Dimas K">K Dimas</name></author><author><name sortKey="Wagner, M" uniqKey="Wagner M">M Wagner</name></author><author><name sortKey="Demetzos, C" uniqKey="Demetzos C">C Demetzos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Henry, Ge" uniqKey="Henry G">GE Henry</name></author><author><name sortKey="Seeram, Np" uniqKey="Seeram N">NP Seeram</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alia, M" uniqKey="Alia M">M Alía</name></author><author><name sortKey="Mateos, R" uniqKey="Mateos R">R Mateos</name></author><author><name sortKey="Ramos, S" uniqKey="Ramos S">S Ramos</name></author><author><name sortKey="Lecumberri, E" uniqKey="Lecumberri E">E Lecumberri</name></author><author><name sortKey="Bravo, L" uniqKey="Bravo L">L Bravo</name></author><author><name sortKey="Goya, L" uniqKey="Goya L">L Goya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bellocco, E" uniqKey="Bellocco E">E Bellocco</name></author><author><name sortKey="Barreca, D" uniqKey="Barreca D">D Barreca</name></author><author><name sortKey="Lagana, G" uniqKey="Lagana G">G Laganà</name></author><author><name sortKey="Leuzzi, U" uniqKey="Leuzzi U">U Leuzzi</name></author><author><name sortKey="Tellone, E" uniqKey="Tellone E">E Tellone</name></author><author><name sortKey="Ficarra, S" uniqKey="Ficarra S">S Ficarra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramos, Aa" uniqKey="Ramos A">AA Ramos</name></author><author><name sortKey="Lima, Cf" uniqKey="Lima C">CF Lima</name></author><author><name sortKey="Pereira, Ml" uniqKey="Pereira M">ML Pereira</name></author><author><name sortKey="Fernandes Ferreira, M" uniqKey="Fernandes Ferreira M">M Fernandes-Ferreira</name></author><author><name sortKey="Pereira Wilson, C" uniqKey="Pereira Wilson C">C Pereira-Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsai, Yc" uniqKey="Tsai Y">YC Tsai</name></author><author><name sortKey="Lin, Cl" uniqKey="Lin C">CL Lin</name></author><author><name sortKey="Chen, Bh" uniqKey="Chen B">BH Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, Xh" uniqKey="Wei X">XH Wei</name></author><author><name sortKey="Yang, Sj" uniqKey="Yang S">SJ Yang</name></author><author><name sortKey="Liang, N" uniqKey="Liang N">N Liang</name></author><author><name sortKey="Hu, Dy" uniqKey="Hu D">DY Hu</name></author><author><name sortKey="Jin, Lh" uniqKey="Jin L">LH Jin</name></author><author><name sortKey="Xue, W" uniqKey="Xue W">W Xue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fang, Sc" uniqKey="Fang S">SC Fang</name></author><author><name sortKey="Hsu, Cl" uniqKey="Hsu C">CL Hsu</name></author><author><name sortKey="Lin, Ht" uniqKey="Lin H">HT Lin</name></author><author><name sortKey="Yen, Gc" uniqKey="Yen G">GC Yen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moghaddam, G" uniqKey="Moghaddam G">G Moghaddam</name></author><author><name sortKey="Ebrahimi, Sa" uniqKey="Ebrahimi S">SA Ebrahimi</name></author><author><name sortKey="Rahbar Roshandel, N" uniqKey="Rahbar Roshandel N">N Rahbar-Roshandel</name></author><author><name sortKey="Foroumadi, A" uniqKey="Foroumadi A">A Foroumadi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hakimuddin, F" uniqKey="Hakimuddin F">F Hakimuddin</name></author><author><name sortKey="Paliyath, G" uniqKey="Paliyath G">G Paliyath</name></author><author><name sortKey="Meckling, K" uniqKey="Meckling K">K Meckling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miranda, Cl" uniqKey="Miranda C">CL Miranda</name></author><author><name sortKey="Stevens, Jf" uniqKey="Stevens J">JF Stevens</name></author><author><name sortKey="Helmrich, A" uniqKey="Helmrich A">A Helmrich</name></author><author><name sortKey="Henderson, Mc" uniqKey="Henderson M">MC Henderson</name></author><author><name sortKey="Rodriguez, Rj" uniqKey="Rodriguez R">RJ Rodriguez</name></author><author><name sortKey="Yang, Yh" uniqKey="Yang Y">YH Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="So, Fv" uniqKey="So F">FV So</name></author><author><name sortKey="Guthrie, N" uniqKey="Guthrie N">N Guthrie</name></author><author><name sortKey="Chambers, Af" uniqKey="Chambers A">AF Chambers</name></author><author><name sortKey="Carroll, Kk" uniqKey="Carroll K">KK Carroll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yelani, T" uniqKey="Yelani T">T Yelani</name></author><author><name sortKey="Hussein, Aa" uniqKey="Hussein A">AA Hussein</name></author><author><name sortKey="Meyer, Jj" uniqKey="Meyer J">JJ Meyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="So, Fv" uniqKey="So F">FV So</name></author><author><name sortKey="Guthrie, N" uniqKey="Guthrie N">N Guthrie</name></author><author><name sortKey="Chambers, Af" uniqKey="Chambers A">AF Chambers</name></author><author><name sortKey="Moussa, M" uniqKey="Moussa M">M Moussa</name></author><author><name sortKey="Carroll, Kk" uniqKey="Carroll K">KK Carroll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, Cy" uniqKey="Jin C">CY Jin</name></author><author><name sortKey="Park, C" uniqKey="Park C">C Park</name></author><author><name sortKey="Hwang, Hj" uniqKey="Hwang H">HJ Hwang</name></author><author><name sortKey="Kim, Gy" uniqKey="Kim G">GY Kim</name></author><author><name sortKey="Choi, Bt" uniqKey="Choi B">BT Choi</name></author><author><name sortKey="Kim, Wj" uniqKey="Kim W">WJ Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeon, Sh" uniqKey="Jeon S">SH Jeon</name></author><author><name sortKey="Chun, W" uniqKey="Chun W">W Chun</name></author><author><name sortKey="Choi, Yj" uniqKey="Choi Y">YJ Choi</name></author><author><name sortKey="Kwon, Ys" uniqKey="Kwon Y">YS Kwon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alshatwi, Aa" uniqKey="Alshatwi A">AA Alshatwi</name></author><author><name sortKey="Ramesh, E" uniqKey="Ramesh E">E Ramesh</name></author><author><name sortKey="Periasamy, Vs" uniqKey="Periasamy V">VS Periasamy</name></author><author><name sortKey="Subash Babu, P" uniqKey="Subash Babu P">P Subash-Babu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Cj" uniqKey="Lee C">CJ Lee</name></author><author><name sortKey="Wilson, L" uniqKey="Wilson L">L Wilson</name></author><author><name sortKey="Jordan, Ma" uniqKey="Jordan M">MA Jordan</name></author><author><name sortKey="Nguyen, V" uniqKey="Nguyen V">V Nguyen</name></author><author><name sortKey="Tang, J" uniqKey="Tang J">J Tang</name></author><author><name sortKey="Smiyun, G" uniqKey="Smiyun G">G Smiyun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruela De Sousa, Rr" uniqKey="Ruela De Sousa R">RR Ruela-de-Sousa</name></author><author><name sortKey="Fuhler, Gm" uniqKey="Fuhler G">GM Fuhler</name></author><author><name sortKey="Blom, N" uniqKey="Blom N">N Blom</name></author><author><name sortKey="Ferreira, Cv" uniqKey="Ferreira C">CV Ferreira</name></author><author><name sortKey="Aoyama, H" uniqKey="Aoyama H">H Aoyama</name></author><author><name sortKey="Peppelenbosch, Mp" uniqKey="Peppelenbosch M">MP Peppelenbosch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vargo, Ma" uniqKey="Vargo M">MA Vargo</name></author><author><name sortKey="Voss, Oh" uniqKey="Voss O">OH Voss</name></author><author><name sortKey="Poustka, F" uniqKey="Poustka F">F Poustka</name></author><author><name sortKey="Cardounel, Aj" uniqKey="Cardounel A">AJ Cardounel</name></author><author><name sortKey="Grotewold, E" uniqKey="Grotewold E">E Grotewold</name></author><author><name sortKey="Doseff, Ai" uniqKey="Doseff A">AI Doseff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sonoda, M" uniqKey="Sonoda M">M Sonoda</name></author><author><name sortKey="Nishiyama, T" uniqKey="Nishiyama T">T Nishiyama</name></author><author><name sortKey="Matsukawa, Y" uniqKey="Matsukawa Y">Y Matsukawa</name></author><author><name sortKey="Moriyasu, M" uniqKey="Moriyasu M">M Moriyasu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, Pw" uniqKey="Zheng P">PW Zheng</name></author><author><name sortKey="Chaing, Lc" uniqKey="Chaing L">LC Chaing</name></author><author><name sortKey="Lin, Cc" uniqKey="Lin C">CC Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, D" uniqKey="Chen D">D Chen</name></author><author><name sortKey="Landis Piwowar, Kr" uniqKey="Landis Piwowar K">KR Landis-Piwowar</name></author><author><name sortKey="Chen, Ms" uniqKey="Chen M">MS Chen</name></author><author><name sortKey="Dou, Qp" uniqKey="Dou Q">QP Dou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, Ej" uniqKey="Choi E">EJ Choi</name></author><author><name sortKey="Kim, Gh" uniqKey="Kim G">GH Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, Ej" uniqKey="Choi E">EJ Choi</name></author><author><name sortKey="Kim, Gh" uniqKey="Kim G">GH Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salama, Mm" uniqKey="Salama M">MM Salama</name></author><author><name sortKey="Kandil, Za" uniqKey="Kandil Z">ZA Kandil</name></author><author><name sortKey="Islam, Wt" uniqKey="Islam W">WT Islam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Forgo, P" uniqKey="Forgo P">P Forgo</name></author><author><name sortKey="Zupk, I" uniqKey="Zupk I">I Zupkó</name></author><author><name sortKey="Molnar, J" uniqKey="Molnar J">J Molnár</name></author><author><name sortKey="Vasas, A" uniqKey="Vasas A">A Vasas</name></author><author><name sortKey="Dombi, G" uniqKey="Dombi G">G Dombi</name></author><author><name sortKey="Hohmann, J" uniqKey="Hohmann J">J Hohmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirano, T" uniqKey="Hirano T">T Hirano</name></author><author><name sortKey="Oka, K" uniqKey="Oka K">K Oka</name></author><author><name sortKey="Akiba, M" uniqKey="Akiba M">M Akiba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindenmeyer, F" uniqKey="Lindenmeyer F">F Lindenmeyer</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Menashi, S" uniqKey="Menashi S">S Menashi</name></author><author><name sortKey="Soria, C" uniqKey="Soria C">C Soria</name></author><author><name sortKey="Lu, H" uniqKey="Lu H">H Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cardenas, M" uniqKey="Cardenas M">M Cardenas</name></author><author><name sortKey="Marder, M" uniqKey="Marder M">M Marder</name></author><author><name sortKey="Blank, Vc" uniqKey="Blank V">VC Blank</name></author><author><name sortKey="Roguin, Lp" uniqKey="Roguin L">LP Roguin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Csupor Loffler, B" uniqKey="Csupor Loffler B">B Csupor-Löffler</name></author><author><name sortKey="Hajdu, Z" uniqKey="Hajdu Z">Z Hajdú</name></author><author><name sortKey="Zupk, I" uniqKey="Zupk I">I Zupkó</name></author><author><name sortKey="Molnar, J" uniqKey="Molnar J">J Molnár</name></author><author><name sortKey="Forgo, P" uniqKey="Forgo P">P Forgo</name></author><author><name sortKey="Vasas, A" uniqKey="Vasas A">A Vasas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Csupor Loffler, B" uniqKey="Csupor Loffler B">B Csupor-Löffler</name></author><author><name sortKey="Hajdu, Z" uniqKey="Hajdu Z">Z Hajdú</name></author><author><name sortKey="Zupk, I" uniqKey="Zupk I">I Zupkó</name></author><author><name sortKey="Rethy, B" uniqKey="Rethy B">B Réthy</name></author><author><name sortKey="Falkay, G" uniqKey="Falkay G">G Falkay</name></author><author><name sortKey="Forgo, P" uniqKey="Forgo P">P Forgo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Csapi, B" uniqKey="Csapi B">B Csapi</name></author><author><name sortKey="Hajdu, Z" uniqKey="Hajdu Z">Z Hajdú</name></author><author><name sortKey="Zupk, I" uniqKey="Zupk I">I Zupkó</name></author><author><name sortKey="Berenyi, A" uniqKey="Berenyi A">A Berényi</name></author><author><name sortKey="Forgo, P" uniqKey="Forgo P">P Forgo</name></author><author><name sortKey="Szab, P" uniqKey="Szab P">P Szabó</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fullas, F" uniqKey="Fullas F">F Fullas</name></author><author><name sortKey="Hussain, Ra" uniqKey="Hussain R">RA Hussain</name></author><author><name sortKey="Chai, Hb" uniqKey="Chai H">HB Chai</name></author><author><name sortKey="Pezzuto, Jm" uniqKey="Pezzuto J">JM Pezzuto</name></author><author><name sortKey="Soejarto, Dd" uniqKey="Soejarto D">DD Soejarto</name></author><author><name sortKey="Kinghorn, Ad" uniqKey="Kinghorn A">AD Kinghorn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiang, Lc" uniqKey="Chiang L">LC Chiang</name></author><author><name sortKey="Ng, Lt" uniqKey="Ng L">LT Ng</name></author><author><name sortKey="Lin, Ic" uniqKey="Lin I">IC Lin</name></author><author><name sortKey="Kup, Pl" uniqKey="Kup P">PL Kup</name></author><author><name sortKey="Lin, Cc" uniqKey="Lin C">CC Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yee, Sb" uniqKey="Yee S">SB Yee</name></author><author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name></author><author><name sortKey="Chung, Hy" uniqKey="Chung H">HY Chung</name></author><author><name sortKey="Im, Ks" uniqKey="Im K">KS Im</name></author><author><name sortKey="Bae, Sj" uniqKey="Bae S">SJ Bae</name></author><author><name sortKey="Choi, Js" uniqKey="Choi J">JS Choi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Das, S" uniqKey="Das S">S Das</name></author><author><name sortKey="Sas, J" uniqKey="Sas J">J Sas</name></author><author><name sortKey="Samadder, A" uniqKey="Samadder A">A Samadder</name></author><author><name sortKey="Boujedaini, N" uniqKey="Boujedaini N">N Boujedaini</name></author><author><name sortKey="Khuda Bukhsh, Ar" uniqKey="Khuda Bukhsh A">AR Khuda-Bukhsh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="King, Jc" uniqKey="King J">JC King</name></author><author><name sortKey="Lu, Qy" uniqKey="Lu Q">QY Lu</name></author><author><name sortKey="Li, G" uniqKey="Li G">G Li</name></author><author><name sortKey="Moro, A" uniqKey="Moro A">A Moro</name></author><author><name sortKey="Takahashi, H" uniqKey="Takahashi H">H Takahashi</name></author><author><name sortKey="Chen, M" uniqKey="Chen M">M Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ujiki, Mb" uniqKey="Ujiki M">MB Ujiki</name></author><author><name sortKey="Ding, Xz" uniqKey="Ding X">XZ Ding</name></author><author><name sortKey="Salabat, Mr" uniqKey="Salabat M">MR Salabat</name></author><author><name sortKey="Bentrem, Dj" uniqKey="Bentrem D">DJ Bentrem</name></author><author><name sortKey="Golkar, L" uniqKey="Golkar L">L Golkar</name></author><author><name sortKey="Milam, B" uniqKey="Milam B">B Milam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shukla, S" uniqKey="Shukla S">S Shukla</name></author><author><name sortKey="Gupta, S" uniqKey="Gupta S">S Gupta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shenouda, Ns" uniqKey="Shenouda N">NS Shenouda</name></author><author><name sortKey="Zhou, C" uniqKey="Zhou C">C Zhou</name></author><author><name sortKey="Browning, Jd" uniqKey="Browning J">JD Browning</name></author><author><name sortKey="Ansell, Pj" uniqKey="Ansell P">PJ Ansell</name></author><author><name sortKey="Sakla, Ms" uniqKey="Sakla M">MS Sakla</name></author><author><name sortKey="Lubahn, Db" uniqKey="Lubahn D">DB Lubahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Ss" uniqKey="Chen S">SS Chen</name></author><author><name sortKey="Corteling, R" uniqKey="Corteling R">R Corteling</name></author><author><name sortKey="Stevanato, L" uniqKey="Stevanato L">L Stevanato</name></author><author><name sortKey="Sinden, J" uniqKey="Sinden J">J Sinden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cherng, Jm" uniqKey="Cherng J">JM Cherng</name></author><author><name sortKey="Shieh, De" uniqKey="Shieh D">DE Shieh</name></author><author><name sortKey="Chiang, W" uniqKey="Chiang W">W Chiang</name></author><author><name sortKey="Chang, My" uniqKey="Chang M">MY Chang</name></author><author><name sortKey="Chiang, Lc" uniqKey="Chiang L">LC Chiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roy, Mk" uniqKey="Roy M">MK Roy</name></author><author><name sortKey="Nakahara, K" uniqKey="Nakahara K">K Nakahara</name></author><author><name sortKey="Na, Tv" uniqKey="Na T">TV Na</name></author><author><name sortKey="Trakoontivakorn, G" uniqKey="Trakoontivakorn G">G Trakoontivakorn</name></author><author><name sortKey="Takenaka, M" uniqKey="Takenaka M">M Takenaka</name></author><author><name sortKey="Isobe, S" uniqKey="Isobe S">S Isobe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, Z" uniqKey="Ma Z">Z Ma</name></author><author><name sortKey="Otsuyama, K" uniqKey="Otsuyama K">K Otsuyama</name></author><author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name></author><author><name sortKey="Abroun, S" uniqKey="Abroun S">S Abroun</name></author><author><name sortKey="Ishikawa, H" uniqKey="Ishikawa H">H Ishikawa</name></author><author><name sortKey="Tsuyama, N" uniqKey="Tsuyama N">N Tsuyama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ciesielska, E" uniqKey="Ciesielska E">E Ciesielska</name></author><author><name sortKey="Wolszczak, M" uniqKey="Wolszczak M">M Wolszczak</name></author><author><name sortKey="Gulanowski, B" uniqKey="Gulanowski B">B Gulanowski</name></author><author><name sortKey="Szulawska, A" uniqKey="Szulawska A">A Szulawska</name></author><author><name sortKey="Kochman, A" uniqKey="Kochman A">A Kochman</name></author><author><name sortKey="Metodiewa, D" uniqKey="Metodiewa D">D Metodiewa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ishii, K" uniqKey="Ishii K">K Ishii</name></author><author><name sortKey="Tanaka, S" uniqKey="Tanaka S">S Tanaka</name></author><author><name sortKey="Kagami, K" uniqKey="Kagami K">K Kagami</name></author><author><name sortKey="Henmi, K" uniqKey="Henmi K">K Henmi</name></author><author><name sortKey="Toyoda, H" uniqKey="Toyoda H">H Toyoda</name></author><author><name sortKey="Kaise, T" uniqKey="Kaise T">T Kaise</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Austin, Ca" uniqKey="Austin C">CA Austin</name></author><author><name sortKey="Patel, S" uniqKey="Patel S">S Patel</name></author><author><name sortKey="Ono, K" uniqKey="Ono K">K Ono</name></author><author><name sortKey="Nakane, H" uniqKey="Nakane H">H Nakane</name></author><author><name sortKey="Fisher, Lm" uniqKey="Fisher L">LM Fisher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bednar, W" uniqKey="Bednar W">W Bednar</name></author><author><name sortKey="Holzmann, K" uniqKey="Holzmann K">K Holzmann</name></author><author><name sortKey="Marian, B" uniqKey="Marian B">B Marian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liang, Rr" uniqKey="Liang R">RR Liang</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Qi, Ja" uniqKey="Qi J">JA Qi</name></author><author><name sortKey="Wang, Zd" uniqKey="Wang Z">ZD Wang</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Liu, Pj" uniqKey="Liu P">PJ Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsuzaki, Y" uniqKey="Matsuzaki Y">Y Matsuzaki</name></author><author><name sortKey="Kurokawa, N" uniqKey="Kurokawa N">N Kurokawa</name></author><author><name sortKey="Terai, S" uniqKey="Terai S">S Terai</name></author><author><name sortKey="Matsumura, Y" uniqKey="Matsumura Y">Y Matsumura</name></author><author><name sortKey="Kobayashi, N" uniqKey="Kobayashi N">N Kobayashi</name></author><author><name sortKey="Okita, K" uniqKey="Okita K">K Okita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Motoo, Y" uniqKey="Motoo Y">Y Motoo</name></author><author><name sortKey="Sawaby, N" uniqKey="Sawaby N">N Sawaby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leung, Hw" uniqKey="Leung H">HW Leung</name></author><author><name sortKey="Yang, Wh" uniqKey="Yang W">WH Yang</name></author><author><name sortKey="Lai, My" uniqKey="Lai M">MY Lai</name></author><author><name sortKey="Lin, Cj" uniqKey="Lin C">CJ Lin</name></author><author><name sortKey="Lee, Hz" uniqKey="Lee H">HZ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boik, Jc" uniqKey="Boik J">JC Boik</name></author><author><name sortKey="Newman, Ra" uniqKey="Newman R">RA Newman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, Yh" uniqKey="Cheng Y">YH Cheng</name></author><author><name sortKey="Li, La" uniqKey="Li L">LA Li</name></author><author><name sortKey="Lin, P" uniqKey="Lin P">P Lin</name></author><author><name sortKey="Cheng, Lc" uniqKey="Cheng L">LC Cheng</name></author><author><name sortKey="Hung, Ch" uniqKey="Hung C">CH Hung</name></author><author><name sortKey="Chang, Nw" uniqKey="Chang N">NW Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pidgeon, Gp" uniqKey="Pidgeon G">GP Pidgeon</name></author><author><name sortKey="Kandouz, M" uniqKey="Kandouz M">M Kandouz</name></author><author><name sortKey="Meram, A" uniqKey="Meram A">A Meram</name></author><author><name sortKey="Honn, Kv" uniqKey="Honn K">KV Honn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pilatova, M" uniqKey="Pilatova M">M Pilátová</name></author><author><name sortKey="Stupakova, V" uniqKey="Stupakova V">V Stupáková</name></author><author><name sortKey="Varinska, L" uniqKey="Varinska L">L Varinská</name></author><author><name sortKey="Sarissk, M" uniqKey="Sarissk M">M Sarisský</name></author><author><name sortKey="Mirossay, L" uniqKey="Mirossay L">L Mirossay</name></author><author><name sortKey="Mirossay, A" uniqKey="Mirossay A">A Mirossay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ai, Xh" uniqKey="Ai X">XH Ai</name></author><author><name sortKey="Zheng, X" uniqKey="Zheng X">X Zheng</name></author><author><name sortKey="Tang, Xq" uniqKey="Tang X">XQ Tang</name></author><author><name sortKey="Sun, L" uniqKey="Sun L">L Sun</name></author><author><name sortKey="Zhang, Yq" uniqKey="Zhang Y">YQ Zhang</name></author><author><name sortKey="Qin, Y" uniqKey="Qin Y">Y Qin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, T" uniqKey="Zhang T">T Zhang</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Qu, L" uniqKey="Qu L">L Qu</name></author><author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name></author><author><name sortKey="Cui, R" uniqKey="Cui R">R Cui</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lyu, Sy" uniqKey="Lyu S">SY Lyu</name></author><author><name sortKey="Park, Wb" uniqKey="Park W">WB Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kilani Jaziri, S" uniqKey="Kilani Jaziri S">S Kilani-Jaziri</name></author><author><name sortKey="Neffati, A" uniqKey="Neffati A">A Neffati</name></author><author><name sortKey="Limem, I" uniqKey="Limem I">I Limem</name></author><author><name sortKey="Boubaker, J" uniqKey="Boubaker J">J Boubaker</name></author><author><name sortKey="Skandrani, I" uniqKey="Skandrani I">I Skandrani</name></author><author><name sortKey="Sghair, Mb" uniqKey="Sghair M">MB Sghair</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiang, Lc" uniqKey="Chiang L">LC Chiang</name></author><author><name sortKey="Cianh, W" uniqKey="Cianh W">W Cianh</name></author><author><name sortKey="Chang, My" uniqKey="Chang M">MY Chang</name></author><author><name sortKey="Ng, Lt" uniqKey="Ng L">LT Ng</name></author><author><name sortKey="Lin, Cc" uniqKey="Lin C">CC Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saleem, A" uniqKey="Saleem A">A Saleem</name></author><author><name sortKey="Husheem, M" uniqKey="Husheem M">M Husheem</name></author><author><name sortKey="H Rkonen, P" uniqKey="H Rkonen P">P Härkönen</name></author><author><name sortKey="Pihlaja, K" uniqKey="Pihlaja K">K Pihlaja</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Afifi, Fu" uniqKey="Afifi F">FU Afifi</name></author><author><name sortKey="Abu Dahab, R" uniqKey="Abu Dahab R">R Abu-Dahab</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsu, Hf" uniqKey="Hsu H">HF Hsu</name></author><author><name sortKey="Houng, Jy" uniqKey="Houng J">JY Houng</name></author><author><name sortKey="Chang, Cl" uniqKey="Chang C">CL Chang</name></author><author><name sortKey="Wu, Cc" uniqKey="Wu C">CC Wu</name></author><author><name sortKey="Chang, Fr" uniqKey="Chang F">FR Chang</name></author><author><name sortKey="Wu, Yc" uniqKey="Wu Y">YC Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, As" uniqKey="Lin A">AS Lin</name></author><author><name sortKey="Lin, Cr" uniqKey="Lin C">CR Lin</name></author><author><name sortKey="Du, Yc" uniqKey="Du Y">YC Du</name></author><author><name sortKey="Lubken, T" uniqKey="Lubken T">T Lübken</name></author><author><name sortKey="Chiang, My" uniqKey="Chiang M">MY Chiang</name></author><author><name sortKey="Chen, Ih" uniqKey="Chen I">IH Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name></author><author><name sortKey="Yi, W" uniqKey="Yi W">W Yi</name></author><author><name sortKey="Jin, L" uniqKey="Jin L">L Jin</name></author><author><name sortKey="Hu, D" uniqKey="Hu D">D Hu</name></author><author><name sortKey="Song, B" uniqKey="Song B">B Song</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xie, Yy" uniqKey="Xie Y">YY Xie</name></author><author><name sortKey="Yuan, D" uniqKey="Yuan D">D Yuan</name></author><author><name sortKey="Yang, Jy" uniqKey="Yang J">JY Yang</name></author><author><name sortKey="Wang, Lh" uniqKey="Wang L">LH Wang</name></author><author><name sortKey="Wu, Cf" uniqKey="Wu C">CF Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Hj" uniqKey="Lee H">HJ Lee</name></author><author><name sortKey="Wang, Cj" uniqKey="Wang C">CJ Wang</name></author><author><name sortKey="Kuo, Hc" uniqKey="Kuo H">HC Kuo</name></author><author><name sortKey="Chou, Fp" uniqKey="Chou F">FP Chou</name></author><author><name sortKey="Jean, Lf" uniqKey="Jean L">LF Jean</name></author><author><name sortKey="Tseng, Th" uniqKey="Tseng T">TH Tseng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoo, Dr" uniqKey="Yoo D">DR Yoo</name></author><author><name sortKey="Jang, Yh" uniqKey="Jang Y">YH Jang</name></author><author><name sortKey="Jeon, Yk" uniqKey="Jeon Y">YK Jeon</name></author><author><name sortKey="Kim, Jy" uniqKey="Kim J">JY Kim</name></author><author><name sortKey="Jeon, W" uniqKey="Jeon W">W Jeon</name></author><author><name sortKey="Choi, Yj" uniqKey="Choi Y">YJ Choi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chang, J" uniqKey="Chang J">J Chang</name></author><author><name sortKey="Hsu, Y" uniqKey="Hsu Y">Y Hsu</name></author><author><name sortKey="Kuo, P" uniqKey="Kuo P">P Kuo</name></author><author><name sortKey="Kuo, Y" uniqKey="Kuo Y">Y Kuo</name></author><author><name sortKey="Chiang, L" uniqKey="Chiang L">L Chiang</name></author><author><name sortKey="Lin, C" uniqKey="Lin C">C Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, J" uniqKey="Yu J">J Yu</name></author><author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name></author><author><name sortKey="Lei, J" uniqKey="Lei J">J Lei</name></author><author><name sortKey="Tan, W" uniqKey="Tan W">W Tan</name></author><author><name sortKey="Hu, X" uniqKey="Hu X">X Hu</name></author><author><name sortKey="Zou, G" uniqKey="Zou G">G Zou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name></author><author><name sortKey="Yang, G" uniqKey="Yang G">G Yang</name></author><author><name sortKey="Ren, D" uniqKey="Ren D">D Ren</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Yin, Q" uniqKey="Yin Q">Q Yin</name></author><author><name sortKey="Sun, X" uniqKey="Sun X">X Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Tt" uniqKey="Wang T">TT Wang</name></author><author><name sortKey="Wang, Sk" uniqKey="Wang S">SK Wang</name></author><author><name sortKey="Huang, Gl" uniqKey="Huang G">GL Huang</name></author><author><name sortKey="Sun, Gj" uniqKey="Sun G">GJ Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harris, Dm" uniqKey="Harris D">DM Harris</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Chen, M" uniqKey="Chen M">M Chen</name></author><author><name sortKey="Lagunero, Ft" uniqKey="Lagunero F">FT Lagunero</name></author><author><name sortKey="Go, Vl" uniqKey="Go V">VL Go</name></author><author><name sortKey="Boros, Lg" uniqKey="Boros L">LG Boros</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luo, G" uniqKey="Luo G">G Luo</name></author><author><name sortKey="Guan, X" uniqKey="Guan X">X Guan</name></author><author><name sortKey="Zhou, L" uniqKey="Zhou L">L Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lust, S" uniqKey="Lust S">S Lust</name></author><author><name sortKey="Vanhoecke, B" uniqKey="Vanhoecke B">B Vanhoecke</name></author><author><name sortKey="Van Gele, M" uniqKey="Van Gele M">M Van Gele</name></author><author><name sortKey="Philippe, J" uniqKey="Philippe J">J Philippé</name></author><author><name sortKey="Bracke, M" uniqKey="Bracke M">M Bracke</name></author><author><name sortKey="Offner, F" uniqKey="Offner F">F Offner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, St" uniqKey="Huang S">ST Huang</name></author><author><name sortKey="Wang, Cy" uniqKey="Wang C">CY Wang</name></author><author><name sortKey="Yang, Rc" uniqKey="Yang R">RC Yang</name></author><author><name sortKey="Chu, Cj" uniqKey="Chu C">CJ Chu</name></author><author><name sortKey="Wu, Ht" uniqKey="Wu H">HT Wu</name></author><author><name sortKey="Pang, Jh" uniqKey="Pang J">JH Pang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, Js" uniqKey="Yu J">JS Yu</name></author><author><name sortKey="Kim, Ak" uniqKey="Kim A">AK Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Kf" uniqKey="Huang K">KF Huang</name></author><author><name sortKey="Zhang, Gd" uniqKey="Zhang G">GD Zhang</name></author><author><name sortKey="Huang, Yq" uniqKey="Huang Y">YQ Huang</name></author><author><name sortKey="Diao, Y" uniqKey="Diao Y">Y Diao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Dh" uniqKey="Lee D">DH Lee</name></author><author><name sortKey="Kim, C" uniqKey="Kim C">C Kim</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Lee, Yj" uniqKey="Lee Y">YJ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Guo, Q" uniqKey="Guo Q">Q Guo</name></author><author><name sortKey="You, Q" uniqKey="You Q">Q You</name></author><author><name sortKey="Zhang, K" uniqKey="Zhang K">K Zhang</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Yu, J" uniqKey="Yu J">J Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cao, Xd" uniqKey="Cao X">XD Cao</name></author><author><name sortKey="Ding, Zs" uniqKey="Ding Z">ZS Ding</name></author><author><name sortKey="Jiang, Fs" uniqKey="Jiang F">FS Jiang</name></author><author><name sortKey="Ding, Xh" uniqKey="Ding X">XH Ding</name></author><author><name sortKey="Chen, Jz" uniqKey="Chen J">JZ Chen</name></author><author><name sortKey="Chen, Sh" uniqKey="Chen S">SH Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Dh" uniqKey="Lee D">DH Lee</name></author><author><name sortKey="Rhee, Jg" uniqKey="Rhee J">JG Rhee</name></author><author><name sortKey="Lee, Yj" uniqKey="Lee Y">YJ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shieh, De" uniqKey="Shieh D">DE Shieh</name></author><author><name sortKey="Cheng, Hy" uniqKey="Cheng H">HY Cheng</name></author><author><name sortKey="Yen, Mh" uniqKey="Yen M">MH Yen</name></author><author><name sortKey="Chiang, Lc" uniqKey="Chiang L">LC Chiang</name></author><author><name sortKey="Lin, Cc" uniqKey="Lin C">CC Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mao, W" uniqKey="Mao W">W Mao</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Yang, T" uniqKey="Yang T">T Yang</name></author><author><name sortKey="Yin, Y" uniqKey="Yin Y">Y Yin</name></author><author><name sortKey="Ge, M" uniqKey="Ge M">M Ge</name></author><author><name sortKey="Luo, M" uniqKey="Luo M">M Luo</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Pharmacogn Rev</journal-id><journal-id journal-id-type="iso-abbrev">Pharmacogn Rev</journal-id><journal-id journal-id-type="publisher-id">PRev</journal-id><journal-title-group><journal-title>Pharmacognosy Reviews</journal-title></journal-title-group><issn pub-type="ppub">0973-7847</issn><issn pub-type="epub">0976-2787</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25125885</article-id><article-id pub-id-type="pmc">4127821</article-id><article-id pub-id-type="publisher-id">PRev-8-122</article-id><article-id pub-id-type="doi">10.4103/0973-7847.134247</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title>Cytotoxicity of dietary flavonoids on different human cancer types</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sak</surname><given-names>Katrin</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib></contrib-group><aff id="aff1"><italic>Non Government Organization Praeventio, Tartu, Estonia</italic></aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Dr. Katrin Sak, NGO Praeventio, Näituse 22-3, Tartu 50407, Estonia. E-mail: <email xlink:href="katrin.sak. 001@mail.ee">katrin.sak. 001@mail.ee</email></corresp></author-notes><pub-date pub-type="ppub"><season>Jul-Dec</season><year>2014</year></pub-date><volume>8</volume><issue>16</issue><fpage>122</fpage><lpage>146</lpage><history><date date-type="received"><day>01</day><month>2</month><year>2014</year></date><date date-type="rev-recd"><day>27</day><month>3</month><year>2014</year></date><date date-type="accepted"><day>10</day><month>6</month><year>2014</year></date></history><permissions><copyright-statement>Copyright: © Pharmacognosy Reviews</copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Flavonoids are ubiquitous in nature. They are also in food, providing an essential link between diet and prevention of chronic diseases including cancer. Anticancer effects of these polyphenols depend on several factors: Their chemical structure and concentration, and also on the type of cancer. Malignant cells from different tissues reveal somewhat different sensitivity toward flavonoids and, therefore, the preferences of the most common dietary flavonoids to various human cancer types are analyzed in this review. While luteolin and kaempferol can be considered as promising candidate agents for treatment of gastric and ovarian cancers, respectively, apigenin, chrysin, and luteolin have good perspectives as potent antitumor agents for cervical cancer; cells from main sites of flavonoid metabolism (colon and liver) reveal rather large fluctuations in anticancer activity probably due to exposure to various metabolites with different activities. Anticancer effect of flavonoids toward blood cancer cells depend on their myeloid, lymphoid, or erythroid origin; cytotoxic effects of flavonoids on breast and prostate cancer cells are highly related to the expression of hormone receptors. Different flavonoids are often preferentially present in certain food items, and knowledge about the malignant tissue-specific anticancer effects of flavonoids could be purposely applied both in chemoprevention as well as in cancer treatment.</p></abstract><kwd-group><kwd>Diet</kwd><kwd>flavonoids</kwd><kwd>human cancers</kwd><kwd>prevention</kwd><kwd>treatment</kwd></kwd-group></article-meta></front><body><sec sec-type="intro" id="sec1-1"><title>INTRODUCTION</title><p>Numerous edible plant-derived compounds have been linked to the chemoprevention and treatment of cancer.[<xref rid="ref1" ref-type="bibr">1</xref><xref rid="ref2" ref-type="bibr">2</xref><xref rid="ref3" ref-type="bibr">3</xref><xref rid="ref4" ref-type="bibr">4</xref><xref rid="ref5" ref-type="bibr">5</xref><xref rid="ref6" ref-type="bibr">6</xref><xref rid="ref7" ref-type="bibr">7</xref><xref rid="ref8" ref-type="bibr">8</xref><xref rid="ref9" ref-type="bibr">9</xref>] For the past decades, much research has been developed in order to discover natural compounds with potential anticancer activity[<xref rid="ref6" ref-type="bibr">6</xref><xref rid="ref10" ref-type="bibr">10</xref><xref rid="ref11" ref-type="bibr">11</xref><xref rid="ref12" ref-type="bibr">12</xref>] and several plant-derived agents (e.g., paclitaxel, docetaxel; vinblastine, vincristine; topotecan, irinotecan, etoposide, etc.) have been successfully used for cancer treatments.[<xref rid="ref13" ref-type="bibr">13</xref><xref rid="ref14" ref-type="bibr">14</xref><xref rid="ref15" ref-type="bibr">15</xref>] Among the anticancer medications, 69% of drugs approved between 1940 and 2002 are either natural products or developed based on knowledge gained from natural products,[<xref rid="ref16" ref-type="bibr">16</xref><xref rid="ref17" ref-type="bibr">17</xref>] a rate which is much higher than in other areas of drug development.[<xref rid="ref18" ref-type="bibr">18</xref>] Natural products offer an untold diversity of chemical structures, and it is very likely that phytochemicals will continue to be important in cancer therapeutics.[<xref rid="ref19" ref-type="bibr">19</xref><xref rid="ref20" ref-type="bibr">20</xref><xref rid="ref21" ref-type="bibr">21</xref>] Application of plants in the treatment of cancer seems to be inevitable, constituting the basis for modern medical science and providing a great source for new drugs.[<xref rid="ref22" ref-type="bibr">22</xref><xref rid="ref23" ref-type="bibr">23</xref>]</p><p>Medicine and one's daily food are equally important in making a sick body well.[<xref rid="ref24" ref-type="bibr">24</xref>] Diet is intimately linked to both the incidence and avoidance of many types of cancer[<xref rid="ref25" ref-type="bibr">25</xref>] and dietary behavior has been identified as one of the most important modifiable determinants of cancer risk.[<xref rid="ref26" ref-type="bibr">26</xref>] Strong and consistent epidemiological evidences suggest that a diet enriched with naturally occurring substances significantly reduces the risk for many cancers.[<xref rid="ref27" ref-type="bibr">27</xref><xref rid="ref28" ref-type="bibr">28</xref><xref rid="ref29" ref-type="bibr">29</xref><xref rid="ref30" ref-type="bibr">30</xref><xref rid="ref31" ref-type="bibr">31</xref>] Indeed, the adoption of diets rich in vegetables and fruits, together with the maintenance of physical activity and appropriate body mass, could reduce the cancer incidence by 30-40%.[<xref rid="ref32" ref-type="bibr">32</xref><xref rid="ref33" ref-type="bibr">33</xref><xref rid="ref34" ref-type="bibr">34</xref>] Moreover, several studies suggest that there is a decreased risk for different types of cancer among vegetarians.[<xref rid="ref35" ref-type="bibr">35</xref>] Numerous classes of compounds present in fruits and vegetables are assumed to take the role of cancer-preventive agents. Among these compounds, flavonoids have been proven to be particularly important.[<xref rid="ref27" ref-type="bibr">27</xref><xref rid="ref29" ref-type="bibr">29</xref><xref rid="ref36" ref-type="bibr">36</xref>]</p></sec><sec id="sec1-2"><title>FLAVONOIDS AS POTENT ANTICANCER AGENTS</title><p>Flavonoids are naturally occurring polyphenolic metabolites distributed throughout the plant kingdom and found in substantial amounts in fruits, vegetables, grains, nuts, seeds, tea, and traditional medicinal herbs.[<xref rid="ref37" ref-type="bibr">37</xref><xref rid="ref38" ref-type="bibr">38</xref><xref rid="ref39" ref-type="bibr">39</xref>] Within individual plants, flavonoids occur in every part but are usually concentrated in the leaves and flowers.[<xref rid="ref40" ref-type="bibr">40</xref>] Flavonoids are edible plant pigments responsible for much of the coloring in nature.[<xref rid="ref41" ref-type="bibr">41</xref><xref rid="ref42" ref-type="bibr">42</xref>]</p><p>Many of the different flavonoids are part of the regular human diet. Although they are nonessential dietary factors,[<xref rid="ref9" ref-type="bibr">9</xref>] flavonoids are thought to be nutritionally valuable compounds,[<xref rid="ref43" ref-type="bibr">43</xref>] being the key natural products that provide the most essential link between the diet and prevention of chronic disorders. One of the most investigated activities of flavonoids is their contribution to cancer prevention and treatment.[<xref rid="ref6" ref-type="bibr">6</xref>]</p><p>Several thousand flavonoids are known to occur in nature, defined chemically as compounds containing a phenylchromanone structure (C6-C3-C6) with at least one hydroxyl substituent.[<xref rid="ref44" ref-type="bibr">44</xref><xref rid="ref45" ref-type="bibr">45</xref><xref rid="ref46" ref-type="bibr">46</xref><xref rid="ref47" ref-type="bibr">47</xref>] Flavonoids can be further divided into flavonols, flavones, flavanols, flavanones, anthocyanidins, and isoflavonoids based on the saturation level and opening of the central pyran ring[<xref rid="ref15" ref-type="bibr">15</xref><xref rid="ref45" ref-type="bibr">45</xref><xref rid="ref48" ref-type="bibr">48</xref>] [<xref ref-type="fig" rid="F1">Figure 1</xref>].</p><fig id="F1" position="float"><label>Figure 1</label><caption><p>Scheme of major flavonoid aglycones and their glycosides</p></caption><graphic xlink:href="PRev-8-122-g001"></graphic></fig><p>The daily human intake of flavonoids is quite different in amounts and classes due to various feeding habits of people from different regions and cultures.[<xref rid="ref25" ref-type="bibr">25</xref><xref rid="ref49" ref-type="bibr">49</xref>] Reports of estimated daily consumption of flavonoids range from 20 mg/day to 1 g/day.[<xref rid="ref50" ref-type="bibr">50</xref>] As the total flavonoid intake in Western countries is estimated at 23 mg/day,[<xref rid="ref51" ref-type="bibr">51</xref>] humans consuming high fruit and vegetable diets may ingest up to 1 g of these compounds daily.[<xref rid="ref52" ref-type="bibr">52</xref><xref rid="ref53" ref-type="bibr">53</xref>] No information is available about the content of flavonoids in the diet of vegetarians.[<xref rid="ref54" ref-type="bibr">54</xref><xref rid="ref55" ref-type="bibr">55</xref>] The main food sources of major dietary flavonoids are presented in <xref ref-type="table" rid="T1">Table 1</xref>.</p><table-wrap id="T1" position="float"><label>Table 1</label><caption><p>Structures and main food sources of major flavonoid aglycones and their glycosides</p></caption><graphic xlink:href="PRev-8-122-g002"></graphic></table-wrap><p>As natural products, flavonoids are regarded as safe and easily obtainable, making them ideal candidates for cancer chemoprevention or associated agents in clinical treatment.[<xref rid="ref3" ref-type="bibr">3</xref><xref rid="ref43" ref-type="bibr">43</xref><xref rid="ref56" ref-type="bibr">56</xref>] Almost all artificial agents currently being used in cancer therapy are highly toxic and produce severe damage to normal cells.[<xref rid="ref57" ref-type="bibr">57</xref><xref rid="ref58" ref-type="bibr">58</xref>] The ideal anticancer agent would exert minimal adverse effects on normal tissues with maximal capacity to kill tumor cells and/or inhibit tumor growth.[<xref rid="ref12" ref-type="bibr">12</xref><xref rid="ref34" ref-type="bibr">34</xref>] The lack of substantial toxic effects for long-term therapies and inherent biological activity of flavonoids make them ideal candidates for new therapeutics.[<xref rid="ref16" ref-type="bibr">16</xref><xref rid="ref59" ref-type="bibr">59</xref>] Indeed, flavonoids have been shown to reveal cytotoxic activity toward various human cancer cells with little or no effect on normal cells, and this fact has stimulated large interest in developing of potential flavonoid-based chemotherapeutics for anticancer treatment.[<xref rid="ref60" ref-type="bibr">60</xref><xref rid="ref61" ref-type="bibr">61</xref>]</p><p>Several observations have suggested that natural flavonoids have growth inhibitory effects on various kinds of cancer cells mediated by different molecular targets and acting through diverse metabolic pathways.[<xref rid="ref62" ref-type="bibr">62</xref><xref rid="ref63" ref-type="bibr">63</xref><xref rid="ref64" ref-type="bibr">64</xref>] However, the precise mechanisms responsible for the antitumor effect of flavonoids are still not thoroughly understood.[<xref rid="ref64" ref-type="bibr">64</xref><xref rid="ref65" ref-type="bibr">65</xref>] Flavonoids can easily bind to the cell membrane, penetrate <italic>in vitro</italic> cultured cells, and modulate the cellular metabolic activities.[<xref rid="ref66" ref-type="bibr">66</xref><xref rid="ref67" ref-type="bibr">67</xref>] Mitigation of oxidative damage, inactivation of carcinogen, inhibition of proliferation, promotion of differentiation, induction of cell cycle arrest and apoptosis, impairment of tumor angiogenesis, and suppression of metastasis contribute to the anticarcinogenic activities of flavonoids.[<xref rid="ref24" ref-type="bibr">24</xref><xref rid="ref25" ref-type="bibr">25</xref><xref rid="ref30" ref-type="bibr">30</xref><xref rid="ref32" ref-type="bibr">32</xref><xref rid="ref49" ref-type="bibr">49</xref><xref rid="ref68" ref-type="bibr">68</xref>] These polyphenolic compounds can interact with xenobiotics metabolizing enzymes, inhibit several kinases involved in signal transduction, interact with estrogen type II binding sites, and alter gene expression patterns.[<xref rid="ref61" ref-type="bibr">61</xref><xref rid="ref69" ref-type="bibr">69</xref><xref rid="ref70" ref-type="bibr">70</xref><xref rid="ref71" ref-type="bibr">71</xref>]</p><p>Normal cell growth is maintained by the balance between cell proliferation and cell death, and apoptosis is a central regulator of tissue homeostasis.[<xref rid="ref72" ref-type="bibr">72</xref><xref rid="ref73" ref-type="bibr">73</xref>] Cells from a variety of human malignancies have a decreased ability to undergo apoptosis in response to some physiological stimuli. Induction of apoptosis in malignant cells may therefore represent a promising approach to both chemoprevention and chemotherapy, and searching for agents that can specifically trigger apoptosis in tumor cells has become an attractive strategy in anticancer drug discovery.[<xref rid="ref38" ref-type="bibr">38</xref><xref rid="ref74" ref-type="bibr">74</xref><xref rid="ref75" ref-type="bibr">75</xref><xref rid="ref76" ref-type="bibr">76</xref><xref rid="ref77" ref-type="bibr">77</xref>] The anticancer efficacy of flavonoids is due, at least in part to their ability to induce apoptosis of tumor cells.[<xref rid="ref37" ref-type="bibr">37</xref><xref rid="ref78" ref-type="bibr">78</xref><xref rid="ref79" ref-type="bibr">79</xref><xref rid="ref80" ref-type="bibr">80</xref><xref rid="ref81" ref-type="bibr">81</xref>]</p><p>One of the most common incidents required for human cancer development known as a hallmark of malignant cells is deregulation of the cell cycle.[<xref rid="ref35" ref-type="bibr">35</xref><xref rid="ref82" ref-type="bibr">82</xref><xref rid="ref83" ref-type="bibr">83</xref>] Agents that can inhibit cell-cycle progression and lead to cell-growth arrest are very important in cancer prevention and therapy studies,[<xref rid="ref35" ref-type="bibr">35</xref>] and considerable attention has been paid to the ability of dietary flavonoids to inhibit cell-cycle progression.[<xref rid="ref82" ref-type="bibr">82</xref>] Flavonoids have been found to arrest cell-cycle progression at either G<sub>1</sub>/S or G<sub>2</sub>/M boundaries by modulating of multiple cell cycle regulatory proteins.[<xref rid="ref69" ref-type="bibr">69</xref>] Somewhat conflicting results have been reported with regard to the stage-specific arrest caused by one and the same compound,[<xref rid="ref59" ref-type="bibr">59</xref><xref rid="ref84" ref-type="bibr">84</xref>] and several studies have indicated the ability of flavonoids to block the cell growth at more than one stage of the cell cycle.[<xref rid="ref85" ref-type="bibr">85</xref>]</p><p>Due to the polyphenolic structure, flavonoids have been found to possess both anti- and prooxidant action.[<xref rid="ref86" ref-type="bibr">86</xref>] While antioxidant effect and ability to scavenge reactive oxygen species (ROS) have been shown to account for most of the reported biological effects of phenolic compounds, several recent studies have revealed that anticancer activities of flavonoids may be mediated through prooxidant action.[<xref rid="ref49" ref-type="bibr">49</xref><xref rid="ref87" ref-type="bibr">87</xref>] Cancer cells exhibit a higher and more persistent oxidative stress level compared to normal cells, rendering malignant cells more vulnerable to being killed by drugs that boost increased ROS levels, such as some flavonoids.[<xref rid="ref88" ref-type="bibr">88</xref><xref rid="ref89" ref-type="bibr">89</xref><xref rid="ref90" ref-type="bibr">90</xref><xref rid="ref91" ref-type="bibr">91</xref>] Whether a flavonoid acts as anti- or prooxidant depends on its dose, cell type, and also culture conditions.[<xref rid="ref37" ref-type="bibr">37</xref><xref rid="ref90" ref-type="bibr">90</xref><xref rid="ref92" ref-type="bibr">92</xref>]</p><p>The specific activity of flavonoids on cell function can also depend on their chemical structure.[<xref rid="ref93" ref-type="bibr">93</xref><xref rid="ref94" ref-type="bibr">94</xref><xref rid="ref95" ref-type="bibr">95</xref>] The structures of the most common dietary flavonoids are presented in <xref ref-type="table" rid="T1">Table 1</xref>. Important factors affecting cytotoxic and/or antiproliferative activities of polyphenols include the saturation of the C<sub>2</sub>-C<sub>3</sub> bond and the position as well as the number and substitution of hydroxyl groups in the A and B rings.[<xref rid="ref69" ref-type="bibr">69</xref><xref rid="ref96" ref-type="bibr">96</xref><xref rid="ref97" ref-type="bibr">97</xref>] However, even the minor modifications in the molecules can be responsible for strong variations in their activity, and flavonoids with very similar structures could not produce identical biological responses.[<xref rid="ref40" ref-type="bibr">40</xref><xref rid="ref97" ref-type="bibr">97</xref><xref rid="ref98" ref-type="bibr">98</xref><xref rid="ref99" ref-type="bibr">99</xref>] Indeed, some authors have suggested that the anticancer capability of flavonoids cannot be predicted based on their chemical composition and structure,[<xref rid="ref61" ref-type="bibr">61</xref>] and it is the reason why no structure activity relationships are analyzed in the present work.</p></sec><sec id="sec1-3"><title>OBSCURITIES LIMITING THE USE OF FLAVONOIDS IN CANCER CHEMOPREVENTION AND TREATMENT</title><p>Flavonoids have been found to exert cytotoxic activities only at relatively high doses, within the micromolar concentration range.[<xref rid="ref26" ref-type="bibr">26</xref><xref rid="ref82" ref-type="bibr">82</xref><xref rid="ref100" ref-type="bibr">100</xref>] The amount of dietary flavonoids in plasma varies according to several parameters such as functional groups and daily intake.[<xref rid="ref101" ref-type="bibr">101</xref>] However, achieving the plasma levels sufficient to reveal antiproliferative and cytotoxic effects may not be possible via oral administration.[<xref rid="ref9" ref-type="bibr">9</xref><xref rid="ref100" ref-type="bibr">100</xref>] For example, results from human data have shown that a full glass of orange juice supplies about enough naringenin to achieve a plasma concentration of 0.5 μM;[<xref rid="ref102" ref-type="bibr">102</xref>] a one-time consumption of approximately 550 g of grapefruit juice results in a mean peak plasma concentration of 6 μM naringenin;[<xref rid="ref103" ref-type="bibr">103</xref>] the physiological dose of hesperetin attainable from drinking orange juice is in the range of 0.5-6 μM;[<xref rid="ref104" ref-type="bibr">104</xref>] human plasma concentration of hesperidin reaches to 0.5 μM at 5-7 hours after ingestion of 0.5 liter of commercial orange juice providing 400 mg hesperidin;[<xref rid="ref8" ref-type="bibr">8</xref>] typical plasma concentration of apigenin is within 10 nM range;[<xref rid="ref45" ref-type="bibr">45</xref>] the concentration of chrysin in plasma after a single dose of 400 mg remains below 0.1 μM;[<xref rid="ref101" ref-type="bibr">101</xref>] and maximal plasma levels of luteolin reaches to about 0.2 μM at 1-2 hours after oral administration.[<xref rid="ref31" ref-type="bibr">31</xref>] In contrast, methoxylated flavonoids display up to 100-fold higher plasma concentrations on account of the reduced phase II conjugation reactions.[<xref rid="ref101" ref-type="bibr">101</xref>] Higher plasma levels can be achieved through intravenous injection,[<xref rid="ref9" ref-type="bibr">9</xref><xref rid="ref100" ref-type="bibr">100</xref>] and the plasma concentration of flavonoids may also be significantly increased by regular intake for a prolonged period.[<xref rid="ref45" ref-type="bibr">45</xref><xref rid="ref101" ref-type="bibr">101</xref><xref rid="ref105" ref-type="bibr">105</xref>]</p><p>Despite encouraging preclinical results, the usability of flavonoids for chemoprevention has encountered only limited success, largely because of inefficient systemic delivery and bioavailability.[<xref rid="ref106" ref-type="bibr">106</xref><xref rid="ref107" ref-type="bibr">107</xref><xref rid="ref108" ref-type="bibr">108</xref>] Flavonoids are most often found in plant materials in the form of glycosides (bound to sugars), which are better soluble in water than the respective aglycones.[<xref rid="ref47" ref-type="bibr">47</xref><xref rid="ref68" ref-type="bibr">68</xref><xref rid="ref109" ref-type="bibr">109</xref>] Most of the glycosides resist acid hydrolysis in the stomach[<xref rid="ref45" ref-type="bibr">45</xref>] and are deglycosylated by β-glucosidases in the small intestine.[<xref rid="ref69" ref-type="bibr">69</xref>] The aglycones are further glucuronidated and sulphated by the intestinal mucosa and liver before release into the blood serum.[<xref rid="ref47" ref-type="bibr">47</xref><xref rid="ref68" ref-type="bibr">68</xref><xref rid="ref69" ref-type="bibr">69</xref>] It is therefore likely that phytochemicals can accumulate in the small intestine and colon at levels greater than in plasma.[<xref rid="ref110" ref-type="bibr">110</xref>] Bioavailability of flavonoids is determined by different factors, including the sugar moiety of the polyphenolic compound and its further metabolism by the gut microflora,[<xref rid="ref11" ref-type="bibr">11</xref>] showing that different groups of flavonoids may have different pharmacokinetic properties.[<xref rid="ref111" ref-type="bibr">111</xref><xref rid="ref112" ref-type="bibr">112</xref>] Moreover, considerable interindividual variation between humans can also influence the flavonoid metabolism, thus affecting the therapeutic action of polyphenolic compounds.[<xref rid="ref103" ref-type="bibr">103</xref>] Furthermore, the anticancer activity would be related not only to the parent flavonoid ingested but also to its metabolites; therefore, identification and measurement of the physiological flavonoid conjugates are important to thoroughly understand the role of dietary polyphenols in human health.[<xref rid="ref31" ref-type="bibr">31</xref><xref rid="ref52" ref-type="bibr">52</xref><xref rid="ref69" ref-type="bibr">69</xref>]</p></sec><sec id="sec1-4"><title>COMPREHENSIVE ANALYSIS OF CYTOTOXICITY OF FLAVONOIDS ON HUMAN CANCER LINES FROM DIFFERENT ORIGINS</title><p>Flavonoids have been demonstrated to suppress proliferation of various cancerous cells.[<xref rid="ref69" ref-type="bibr">69</xref>] However, not all polyphenolic compounds share the same antiproliferative activity;[<xref rid="ref113" ref-type="bibr">113</xref>] and depending on their structure, flavonoids display differences in the sensitivity and selectivity toward tumor cells.[<xref rid="ref26" ref-type="bibr">26</xref><xref rid="ref97" ref-type="bibr">97</xref><xref rid="ref114" ref-type="bibr">114</xref>] The sensitivities of cancer cells against flavonoids can be different depending on their derived tissues,[<xref rid="ref16" ref-type="bibr">16</xref><xref rid="ref115" ref-type="bibr">115</xref>] indicating that the cytotoxicity induced by flavonoids might be related to selected cancer types.[<xref rid="ref30" ref-type="bibr">30</xref><xref rid="ref116" ref-type="bibr">116</xref>] Even in the case of flavonoids with quite similar structures, there are compound-specific effects which are relevant to modulate particular biochemical processes so that the development of certain neoplasms could be differentially influential pointing to the tissue-specific cytotoxic action.[<xref rid="ref117" ref-type="bibr">117</xref><xref rid="ref118" ref-type="bibr">118</xref>] The effectiveness of flavonoids may vary also because of the different disease etiologies.[<xref rid="ref119" ref-type="bibr">119</xref>]</p><p>It is of interest of the current review article to determine whether the most common dietary flavonoids can exert some clear-cut preferences to certain tumor tissue types. In nature, different members of the flavonoid family are often preferentially present in some food items;[<xref rid="ref120" ref-type="bibr">120</xref>] and knowledge about the malignant tissue-specific cytotoxic effects of flavonoids could be purposely applied both in the chemoprevention based on the genetic cancer risks and familiar anamnesis as well as in the cancer treatment. For this purpose, quantitative data characterizing the cytotoxic effects of different flavonoids on different human tumor cell lines were compiled from the literature sources, and statistical analysis to calculate the respective mean parameters was performed. IC<sub>50</sub> values as the flavonoid concentrations required to inhibit 50% of cell growth are the most common representative indexes of the dose-response curve,[<xref rid="ref121" ref-type="bibr">121</xref>] and these parameters were also used in the current work. The mean cytotoxic constants of the most common dietary flavonoids on cancer cell lines derived from various organ sites are presented in <xref ref-type="table" rid="T2">Table 2</xref>. Cultured human malignant cell lines used for evaluating the cytotoxicity of these compounds are listed in <xref ref-type="table" rid="T3">Table 3</xref>.</p><table-wrap id="T2" position="float"><label>Table 2</label><caption><p>Cytotoxicity of flavonoids on human cancer cell lines derived from various organ sites (mean IC<sub>50</sub>±SE, μM (<italic>n</italic>)). Cell lines used for assays are presented in <xref ref-type="table" rid="T3">Table 3</xref></p></caption><graphic xlink:href="PRev-8-122-g003"></graphic></table-wrap><table-wrap id="T3" position="float"><label>Table 3</label><caption><p>Human cancer cell lines used for cytotoxicity assays of flavonoids</p></caption><graphic xlink:href="PRev-8-122-g004"></graphic></table-wrap><sec id="sec2-1"><title>Paucity of data complicates the analysis</title><p>Despite the extensive investigation carried out with flavonoids in the past decades, there are still quite a few parameters available, characterizing quantitatively the efficacy of polyphenolic compounds on certain cancer types. In this way, the IC<sub>50</sub> values of flavonoids measured using the cells derived from malignant esophageal tissues are too scarce to reveal any certain specificity patterns. At the same time, data measured on bone cancer lines show only very low or even no cytotoxic activity of different flavonoids [<xref ref-type="table" rid="T2">Table 2</xref>].</p><p>Rather, few half-maximal cytotoxic parameters are available also for cell lines derived from human tumors of bladder, mouth, stomach, pancreas, and ovary. However, some activity patterns and tissue specificities of flavonoids can still be brought forth for these organ sites. In the case of bladder, cancer flavones apigenin and luteolin seem to be cytotoxically most active. Besides these two flavones, chrysin and flavonol kaempferol have also been reported to have antiproliferative activity and induce apoptosis in oral cavity cancer cells. Epithelium of the oral cavity can absorb the flavonoids directly, and should benefit for high levels of exposure to these dietary phytochemicals.[<xref rid="ref122" ref-type="bibr">122</xref>]</p><p>Flavones apigenin, baicalein, luteolin, nobiletin, and tangeretin have shown to be the most effective flavonoids against carcinomas of stomach, whereas luteolin has even proposed to be a promising candidate agent for treatment of gastric cancer.[<xref rid="ref123" ref-type="bibr">123</xref>]</p><p>In addition to some flavonols, such as quercetin, fisetin, and galangin, flavanone glycoside hesperidin also inhibits human pancreatic cancer cells, explaining why lime juice rich in hesperidin has been suggested to possess potential in the prevention of pancreatic cancer.[<xref rid="ref124" ref-type="bibr">124</xref>]</p><p>The growth of human ovarian cancer cells cannot only be suppressed by several flavones including apigenin, baicalein, luteolin, and wogonin but also by flavonols quercetin and kaempferol. Kaempferol is a good candidate compound for chemoprevention of ovarian cancer; as in human studies, a significant 40% decrease in incidence of ovarian cancer was detected for individuals with the highest quintile of kaempferol consumption compared to those in the lowest quintile.[<xref rid="ref106" ref-type="bibr">106</xref><xref rid="ref125" ref-type="bibr">125</xref>] The intake of this nontoxic and inexpensive phytochemical can be easily adopted into the lifestyle of most women.[<xref rid="ref126" ref-type="bibr">126</xref>]</p></sec><sec id="sec2-2"><title>Metabolic sites reveal large fluctuations toward flavonoid cytotoxicity</title><p>Present in dietary sources mostly as glycosides, flavonoids are cleaved in intestine by microbial enzymes and further metabolized in colon and liver to release into the blood as different conjugates. In this way, the epithelium of intestine is exposed to higher concentrations of flavonoids and their different metabolites than the tissues at other locations; and this would also be true for the colonic tumor cells, showing that colorectal cancer appears most relevant to dietary factors.[<xref rid="ref45" ref-type="bibr">45</xref><xref rid="ref127" ref-type="bibr">127</xref>] At the same time, the exposure to different metabolites can explain the large fluctuations in cytotoxic constants of flavonoids measured using colorectal and liver cancer cell lines. It is possible that some metabolites could be more cytotoxic than parent compounds, giving a selective anticancer activity advantage <italic>in vivo</italic>.</p><p>The other aspect important to take into consideration by analyzing the cytotoxic data of flavonoids includes their differential effect against tumors with specific mutational spectra. The differential effectiveness of inhibition of cell growth and arresting cell cycle in response to flavonoids in various colorectal cancer cell lines may be associated with the functional status of p53 and/or ras genes. While apigenin has been indicated to have stronger effect on tumors with mutations in genes which are critical to colon cancer development, thus being more effective in controlling the growth of tumors with certain mutational spectra and less effective in wild-type normal cells,[<xref rid="ref29" ref-type="bibr">29</xref><xref rid="ref46" ref-type="bibr">46</xref><xref rid="ref127" ref-type="bibr">127</xref>] kaempferol and hesperetin seem to exhibit higher resistance toward mutant p53 human colon cancer cell lines.[<xref rid="ref125" ref-type="bibr">125</xref><xref rid="ref128" ref-type="bibr">128</xref>]</p><p>Some other flavonoids including quercetin and baicalein have also been shown to be useful agents for prevention and treatment of colon cancer [<xref ref-type="table" rid="T2">Table 2</xref>]. However, compared to quercetin and baicalein, their glycosides rutin and baicalin, respectively showed no growth inhibitory effects on colon cancer cells,[<xref rid="ref20" ref-type="bibr">20</xref><xref rid="ref129" ref-type="bibr">129</xref>] showing that the sugar moiety strongly affects the bioactivity of flavonoids.</p><p>Accumulated evidences have indicated that the growth of hepatocarcinoma cells can be suppressed by flavones apigenin, luteolin, wogonin, and baicalin, thus being valuable for the therapeutic intervention of human hepatomas [<xref ref-type="table" rid="T2">Table 2</xref>]. Apigenin may have some implications also in the prevention of virus infection, leading to liver cancer development;[<xref rid="ref130" ref-type="bibr">130</xref>] wogonin possesses hepatoprotective activities against diverse pathophysiological processes associated with hepatocarcinogenesis and can be extremely competitive as anticancer drugs against malignant hepatoma.[<xref rid="ref131" ref-type="bibr">131</xref><xref rid="ref132" ref-type="bibr">132</xref>]</p></sec><sec id="sec2-3"><title>Blood cells are potent target sites for flavonoids</title><p>Anticancer drugs are generally more effective against leukemia than other malignancies and in this aspect flavonoids are similar to other anticancer agents.[<xref rid="ref24" ref-type="bibr">24</xref>] The mean cytotoxic constants of various flavonoids on different blood cancer cells are depicted in the <xref ref-type="fig" rid="F2">Figure 2</xref> showing that many common dietary polyphenols exhibit growth inhibitory properties against several human hematologic malignancies.</p><fig id="F2" position="float"><label>Figure 2</label><caption><p>Cytotoxic effect of flavonoids on different human blood cancer cell lines</p></caption><graphic xlink:href="PRev-8-122-g005"></graphic></fig><p>Flavonoids hold much promise for the development of new chemotherapeutics in myeloid and lymphoid leukemias.[<xref rid="ref133" ref-type="bibr">133</xref><xref rid="ref134" ref-type="bibr">134</xref><xref rid="ref135" ref-type="bibr">135</xref>] In general, flavonol aglycones (quercetin, kaempferol, myricetin) seem to exhibit somewhat stronger cytotoxic activity against blood cancer cells of myeloid lineage compared to lymphocytic leukemia cell lines, whereas flavonol glycosides have no effect on the viability of different blood cancer cells. In contrast to the inactivity of flavanone naringenin in myeloid and lymphoid leukemia cell lines, this dietary polyphenol exerts cytotoxicity on erythroleukemia cells, thus revealing an opposite situation to flavones (apigenin, luteolin, tangeretin) in which cases strong anticancer activity has been measured in cell lines of myeloid and lymphoid lineages but significantly lower sensitivity is expressed toward erythroleukemia cells [<xref ref-type="fig" rid="F2">Figure 2</xref>]. This knowledge could be specifically applied in chemoprevention as well as clinical trials for treatment of different hematologic malignancies.</p></sec><sec id="sec2-4"><title>Polyphenols affecting both hormone-dependent and -independent tumor cells</title><p>Breast and prostate cancers are hormone-dependent tumors as their development and growth can be dependent on the expression of estrogen receptors (ER) and androgen receptors (AR), respectively.</p><p>Most breast cancers are heterogeneous and consist of ER-positive and -negative cells. Therefore, agents that are able to inhibit the growth of both ER-positive and -negative tumors are of great interest.[<xref rid="ref136" ref-type="bibr">136</xref>] Dietary flavonoids seem to display such dual activity, inhibiting both receptor-positive and -negative breast cancer cells [<xref ref-type="table" rid="T2">Table 2</xref>]. For instance, no difference in the cytotoxicity of naringenin has been found between human breast cancer cell lines expressing or not expressing ERs[<xref rid="ref24" ref-type="bibr">24</xref>] and the regular intake of this flavanone may slow down the rate at which breast cancer cells proliferate.[<xref rid="ref103" ref-type="bibr">103</xref>] High flavone intake has also been significantly correlated with a lower risk of breast cancer[<xref rid="ref68" ref-type="bibr">68</xref>] and apigenin, baicalein, and luteolin may be promising candidate agents in the treatment of mammary tumors.[<xref rid="ref137" ref-type="bibr">137</xref><xref rid="ref138" ref-type="bibr">138</xref><xref rid="ref139" ref-type="bibr">139</xref>] However, although apigenin can target both ER-dependent and -independent pathways, it seems to be somewhat more potent on ER-positive human breast cancer cell lines [<xref ref-type="fig" rid="F3">Figure 3</xref>], thus providing more promise for the treatment of ER-positive tumors.</p><fig id="F3" position="float"><label>Figure 3</label><caption><p>Cytotoxic effect of apigenin on human breast cancer cell lines depending on the expression of estrogen receptors</p></caption><graphic xlink:href="PRev-8-122-g006"></graphic></fig><p>AR are the critical factors for the prostate cancer cell growth and survival and in the development of ablation-resistant prostate tumors. As presented in <xref ref-type="table" rid="T2">Table 2</xref>, flavonoids display anticancer effects both in AR-positive and -negative prostate cancer cell lines. However, flavonol aglycones (quercetin, fisetin, galangin, kaempferol, and myricetin) exert somewhat stronger cytotoxic activity on AR-dependent prostate cancer cells [<xref ref-type="fig" rid="F4">Figure 4</xref>]. Indeed, quercetin has been shown to decrease the androgen receptor expression in 22rv1 human prostate cancer cells,[<xref rid="ref140" ref-type="bibr">140</xref>] whereas fisetin can inhibit the AR signaling pathways[<xref rid="ref141" ref-type="bibr">141</xref><xref rid="ref142" ref-type="bibr">142</xref>] showing that these compounds may afford more health benefits in chemoprevention and earlier stages of prostate carcinogenesis when the tumor is still dependent on the presence of androgens. In contrast, flavanone naringenin seem to display only very low potency toward AR-positive human prostate cancer cells, suppressing at the same time the growth of androgen-independent human prostate cancer lines. Flavones like apigenin, baicalein, and baicalin express rather similar pattern of growth inhibition of both AR-positive and -negative prostate carcinoma cells, thus being independent on androgen receptor status.[<xref rid="ref66" ref-type="bibr">66</xref><xref rid="ref143" ref-type="bibr">143</xref><xref rid="ref144" ref-type="bibr">144</xref>] Flavonoid treatment may offer an alternative strategy to suppress androgen-insensitive prostate tumor growth and flavonoids like naringenin, apigenin, baicalein, chrysin, and luteolin may be developed as promising chemotherapeutic agents against advanced and androgen-independent human prostate tumors.</p><fig id="F4" position="float"><label>Figure 4</label><caption><p>Cytotoxic effect of flavonols on human prostate cancer cell lines depending on the expression of androgen receptors</p></caption><graphic xlink:href="PRev-8-122-g007"></graphic></fig><p>With regards to the structure of flavonoids and nature of substituents, it is especially important to point out the fact that methylation of the hydroxyl groups does not reduce the anticancer capacity but even increases it.[<xref rid="ref61" ref-type="bibr">61</xref><xref rid="ref69" ref-type="bibr">69</xref>] Therefore, polymethoxylated flavonoids, such as tangeretin and nobiletin, can be much more potent inhibitors of tumor cell growth than free hydroxylated flavonoids[<xref rid="ref69" ref-type="bibr">69</xref><xref rid="ref145" ref-type="bibr">145</xref>] [<xref ref-type="table" rid="T2">Table 2</xref>].</p></sec><sec id="sec2-5"><title>Lung and uterine cancer as well as melanoma cells are strongly affected by flavonoids</title><p>Cytotoxic effects of flavonoids on malignant cell lines derived from human lung and cervical cancers as well as melanoma are depicted in <xref ref-type="fig" rid="F5">Figure 5</xref>. Several flavonol aglycones are able to cause decrease in cell viability with half-maximal cytotoxic doses in low micromolar range [<xref ref-type="table" rid="T2">Table 2</xref>], revealing the most potent cytotoxic activity for myricetin in lung cancer cells and quercetin in melanoma and cervical cancer cells. Flavanones display no growth inhibitory effect on lung and cervical cancer cell lines, expressing at the same time some cytotoxicity on human melanoma cells.</p><fig id="F5" position="float"><label>Figure 5</label><caption><p>Cytotoxic effect of flavonoids on different human lung cancer cell lines (a), melanoma cell lines (b), and uterine cancer cell lines (c)</p></caption><graphic xlink:href="PRev-8-122-g008"></graphic></fig><p>Several members of the flavone group display high cytotoxic activity against cervical cancer cells. Apigenin is probably more potent and sensitive in killing cervical cancer cells than cells of melanoma and lung cancer; the same seems to be true also for chrysin. Luteolin exerts high-level activity both in cervical cancer as well as melanoma cell lines, showing that these flavones may have good perspectives as lead compounds of potent antitumor agents for the respective target sites. On the other hand, polymethoxylated flavones nobiletin and tangeretin are among the most effective at inhibiting cancer cell growth of melanoma and lung (tangeretin) and it is also the reason why these dietary polyphenols have emerged as potential drug candidates for treatment of these malignancies [<xref ref-type="table" rid="T2">Table 2</xref>, <xref ref-type="fig" rid="F5">Figure 5</xref>].</p></sec></sec><sec id="sec1-5"><title>CONCLUSIONS AND FURTHER PERSPECTIVES</title><p>Flavonoids can play important beneficial roles in human nutrition and health status and chemoprevention is one of the most realistic and promising approaches for the prevention of malignant disorders.[<xref rid="ref76" ref-type="bibr">76</xref><xref rid="ref118" ref-type="bibr">118</xref>] Diet–health relationships are very complex as food items usually act through multiple pathways and each ingredient can have different molecular targets. It is also the reason why phytochemical combinations may offer greater chemoprevention than administration of single agents alone.[<xref rid="ref110" ref-type="bibr">110</xref>] Both additive as well as synergistic interactions between several dietary flavonoids have been reported,[<xref rid="ref101" ref-type="bibr">101</xref><xref rid="ref146" ref-type="bibr">146</xref>] contributing to the health benefits of fruits and vegetables. Therefore, consumers may gain more significant health benefits from whole foods than from intake of dietary supplements.[<xref rid="ref146" ref-type="bibr">146</xref>] However, individual phenolic compounds may also act antagonistically with other components,[<xref rid="ref147" ref-type="bibr">147</xref><xref rid="ref148" ref-type="bibr">148</xref>] and further efforts are necessary to understand their action modes as well as to provide further information for the cancer prevention in future.[<xref rid="ref149" ref-type="bibr">149</xref>]</p><p>Flavonoids are not only promising food-derived cancer preventive compounds but could also be considered as candidates for chemotherapeutic agents, revealing potential clinical significance in the cancer treatment.[<xref rid="ref73" ref-type="bibr">73</xref><xref rid="ref150" ref-type="bibr">150</xref>] Polyphenolic compounds like quercetin, myricetin, apigenin, baicalein, chrysin, luteolin, nobiletin, and tangeretin might be valuable agents in anticancer strategies and studies of their clinical use for development of novel drugs should be continued. Beneficial effects have been described also by combining certain flavonoids with standard chemotherapeutic drugs leading to decrease in the dosage and associated toxicity while targeting specific resistance mechanisms. In this way, the genotoxic damage caused by standard chemotherapeutics to normal cells can be diminished, thereby reducing the chance of developing of secondary cancers.[<xref rid="ref45" ref-type="bibr">45</xref><xref rid="ref151" ref-type="bibr">151</xref>] Further work is certainly needed to develop and produce novel drugs from natural sources introducing structural variations into the backbone of flavonoids and modifying their structures to further improve biological activity and exhibit more potent anticancer effects.</p><p>Despite a rather short period of investigation of the anticancer action of flavonoids (for instance, apigenin was first proposed to interfere with the process of carcinogenesis only in 1980s),[<xref rid="ref45" ref-type="bibr">45</xref>] this field has undergone an extensive development. The cytotoxic data of flavonoids compiled within the current work and relationships presented in this review article cannot only be useful in chemoprevention to choose the food items containing most active natural polyphenols on malignant cells of certain cancer types, considering the individual genetic cancer risks and familial anamnesis but also in the selection of parent compounds to design and synthesize novel chemotherapy drugs starting from the valuable material given to us by the nature.</p></sec></body><back><fn-group><fn fn-type="supported-by"><p><bold>Source of Support:</bold> Nil</p></fn><fn fn-type="conflict"><p><bold>Conflict of Interest:</bold> None declared</p></fn></fn-group><ref-list><title>REFERENCES</title><ref id="ref1"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mignet</surname><given-names>N</given-names></name><name><surname>Seguin</surname><given-names>J</given-names></name><name><surname>Ramos</surname><given-names>Romano M</given-names></name><name><surname>Brulle</surname><given-names>L</given-names></name><name><surname>Touil</surname><given-names>YS</given-names></name><name><surname>Scherman</surname><given-names>D</given-names></name><etal></etal></person-group><article-title>Development of a liposomal formulation of the natural flavonoid fisetin</article-title><source>Int J Pharm</source><year>2012</year><volume>423</volume><fpage>69</fpage><lpage>76</lpage><pub-id pub-id-type="pmid">21571054</pub-id></element-citation></ref><ref id="ref2"><label>2</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ying</surname><given-names>TH</given-names></name><name><surname>Yang</surname><given-names>SF</given-names></name><name><surname>Tsai</surname><given-names>SJ</given-names></name><name><surname>Hsieh</surname><given-names>SC</given-names></name><name><surname>Huang</surname><given-names>YC</given-names></name><name><surname>Bau</surname><given-names>DT</given-names></name><etal></etal></person-group><article-title>Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway</article-title><source>Arch Toxicol</source><year>2012</year><volume>86</volume><fpage>263</fpage><lpage>73</lpage><pub-id pub-id-type="pmid">21964635</pub-id></element-citation></ref><ref id="ref3"><label>3</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Szliszka</surname><given-names>E</given-names></name><name><surname>Helewski</surname><given-names>KJ</given-names></name><name><surname>Mizgala</surname><given-names>E</given-names></name><name><surname>Krol</surname><given-names>W</given-names></name></person-group><article-title>The dietary flavonol fisetin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells</article-title><source>Int J Oncol</source><year>2011</year><volume>39</volume><fpage>771</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">21743964</pub-id></element-citation></ref><ref id="ref4"><label>4</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Seguin</surname><given-names>J</given-names></name><name><surname>Brullé</surname><given-names>L</given-names></name><name><surname>Boyer</surname><given-names>R</given-names></name><name><surname>Lu</surname><given-names>YM</given-names></name><name><surname>Ramos</surname><given-names>Romano M</given-names></name><name><surname>Touil</surname><given-names>YS</given-names></name><etal></etal></person-group><article-title>Liposomal encapsulation of the natural flavonoid fisetin improves bioavailability and antitumor efficacy</article-title><source>Int J Pharm</source><year>2013</year><volume>444</volume><fpage>146</fpage><lpage>54</lpage><pub-id pub-id-type="pmid">23380621</pub-id></element-citation></ref><ref id="ref5"><label>5</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tolomeo</surname><given-names>M</given-names></name><name><surname>Grimaudo</surname><given-names>S</given-names></name><name><surname>Di Cristina</surname><given-names>A</given-names></name><name><surname>Pipitone</surname><given-names>RM</given-names></name><name><surname>Dusonchet</surname><given-names>L</given-names></name><name><surname>Meli</surname><given-names>M</given-names></name><etal></etal></person-group><article-title>Galangin increases the cytotoxic activity of imatinib mesylate in imatinib-sensitive and imatinib-resistant Bcr-Abl expressing leukemia cells</article-title><source>Cancer Lett</source><year>2008</year><volume>265</volume><fpage>289</fpage><lpage>97</lpage><pub-id pub-id-type="pmid">18374481</pub-id></element-citation></ref><ref id="ref6"><label>6</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jaiswal</surname><given-names>JV</given-names></name><name><surname>Wadegaonkar</surname><given-names>PA</given-names></name><name><surname>Hajare</surname><given-names>SW</given-names></name></person-group><article-title>The bioflavonoid galangin suppresses the growth of ehrlich ascites carcinoma in Swiss Albino mice: A molecular insight</article-title><source>Appl Biochem Biotechnol</source><year>2012</year><volume>167</volume><fpage>1325</fpage><lpage>39</lpage><pub-id pub-id-type="pmid">22434356</pub-id></element-citation></ref><ref id="ref7"><label>7</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhang</surname><given-names>HT</given-names></name><name><surname>Luo</surname><given-names>H</given-names></name><name><surname>Wu</surname><given-names>J</given-names></name><name><surname>Lan</surname><given-names>LB</given-names></name><name><surname>Fan</surname><given-names>DH</given-names></name><name><surname>Zhu</surname><given-names>KD</given-names></name><etal></etal></person-group><article-title>Galangin induces apoptosis of hepatocellular carcinoma cells via the mitochondrial pathway</article-title><source>World J Gastroenterol</source><year>2010</year><volume>16</volume><fpage>3377</fpage><lpage>84</lpage><pub-id pub-id-type="pmid">20632439</pub-id></element-citation></ref><ref id="ref8"><label>8</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hsiao</surname><given-names>YC</given-names></name><name><surname>Hsieh</surname><given-names>YS</given-names></name><name><surname>Kuo</surname><given-names>WH</given-names></name><name><surname>Chiou</surname><given-names>HL</given-names></name><name><surname>Yang</surname><given-names>SF</given-names></name><name><surname>Chiang</surname><given-names>WL</given-names></name><etal></etal></person-group><article-title>The tumor-growth inhibitory activity of flavanone and 2’-OH flavanone <italic>in vitro</italic> and <italic>in vivo</italic> through induction of cell cycle arrest and suppression of cyclins and CDKs</article-title><source>J Biomed Sci</source><year>2007</year><volume>14</volume><fpage>107</fpage><lpage>19</lpage><pub-id pub-id-type="pmid">17031514</pub-id></element-citation></ref><ref id="ref9"><label>9</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ou</surname><given-names>YC</given-names></name><name><surname>Kuan</surname><given-names>YH</given-names></name><name><surname>Li</surname><given-names>JR</given-names></name><name><surname>Raung</surname><given-names>SL</given-names></name><name><surname>Wang</surname><given-names>CC</given-names></name><name><surname>Hung</surname><given-names>YY</given-names></name><etal></etal></person-group><article-title>Induction of apoptosis by luteolin involving akt inactivation in human 786-o renal cell carcinoma cells</article-title><source>Evid Based Complement Alternat Med 2013</source><year>2013</year><comment>109105</comment></element-citation></ref><ref id="ref10"><label>10</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shen</surname><given-names>SC</given-names></name><name><surname>Ko</surname><given-names>CH</given-names></name><name><surname>Tseng</surname><given-names>SW</given-names></name><name><surname>Tsai</surname><given-names>SH</given-names></name><name><surname>Chen</surname><given-names>YC</given-names></name></person-group><article-title>Structurally related antitumor effects of flavanones <italic>in vitro</italic> and <italic>in vivo</italic>: Involvement of caspase 3 activtion, p21 gene expression, and reactive oxygen species production</article-title><source>Toxicol Appl Pharmacol</source><year>2004</year><volume>197</volume><fpage>84</fpage><lpage>95</lpage><pub-id pub-id-type="pmid">15163544</pub-id></element-citation></ref><ref id="ref11"><label>11</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ramesh</surname><given-names>E</given-names></name><name><surname>Alshatwi</surname><given-names>AA</given-names></name></person-group><article-title>Naringin induces death receptor and mitochondria-mediated apoptosis in human cervical cancer (SiHa) cells</article-title><source>Food Chem Toxicol</source><year>2013</year><volume>51</volume><fpage>97</fpage><lpage>105</lpage><pub-id pub-id-type="pmid">22847135</pub-id></element-citation></ref><ref id="ref12"><label>12</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhao</surname><given-names>X</given-names></name><name><surname>Shu</surname><given-names>G</given-names></name><name><surname>Chen</surname><given-names>L</given-names></name><name><surname>Mi</surname><given-names>X</given-names></name><name><surname>Mei</surname><given-names>Z</given-names></name><name><surname>Deng</surname><given-names>X</given-names></name></person-group><article-title>A flavonoid component from Docynia Delavayi (Franch.) Schneid represses transplanted H22 hepatoma growth and exhibits low toxic effect on tumor-bearing mice</article-title><source>Food Chem Toxicol</source><year>2012</year><volume>50</volume><fpage>3166</fpage><lpage>73</lpage><pub-id pub-id-type="pmid">22687553</pub-id></element-citation></ref><ref id="ref13"><label>13</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kim</surname><given-names>JH</given-names></name><name><surname>Jung</surname><given-names>CH</given-names></name><name><surname>Jang</surname><given-names>BH</given-names></name><name><surname>Go</surname><given-names>HY</given-names></name><name><surname>Park</surname><given-names>JH</given-names></name><name><surname>Choi</surname><given-names>YK</given-names></name><etal></etal></person-group><article-title>Selective cytotoxic effects on human cancer cell lines of phenolic-rich ethyl-acetate fraction from Rhus verniciflua Stokes</article-title><source>Am J Chin Med</source><year>2009</year><volume>37</volume><fpage>609</fpage><lpage>20</lpage><pub-id pub-id-type="pmid">19606519</pub-id></element-citation></ref><ref id="ref14"><label>14</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>YL</given-names></name><name><surname>Gan</surname><given-names>GP</given-names></name><name><surname>Zhang</surname><given-names>HZ</given-names></name><name><surname>Wu</surname><given-names>HZ</given-names></name><name><surname>Li</surname><given-names>CL</given-names></name><name><surname>Huang</surname><given-names>YP</given-names></name><etal></etal></person-group><article-title>A flavonoid glycoside isolated from Smilax china L. rhizome <italic>in vitro</italic> anticancer effects on human cancer cell lines</article-title><source>J Ethnopharmacol</source><year>2007</year><volume>113</volume><fpage>115</fpage><lpage>24</lpage><pub-id pub-id-type="pmid">17606345</pub-id></element-citation></ref><ref id="ref15"><label>15</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Attoub</surname><given-names>S</given-names></name><name><surname>Hassan</surname><given-names>AH</given-names></name><name><surname>Vanhoecke</surname><given-names>B</given-names></name><name><surname>Iratni</surname><given-names>R</given-names></name><name><surname>Takahashi</surname><given-names>T</given-names></name><name><surname>Gaben</surname><given-names>AM</given-names></name><etal></etal></person-group><article-title>Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells</article-title><source>Eur J Pharmacol</source><year>2011</year><volume>651</volume><fpage>18</fpage><lpage>25</lpage><pub-id pub-id-type="pmid">21074525</pub-id></element-citation></ref><ref id="ref16"><label>16</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li-Weber</surname><given-names>M</given-names></name></person-group><article-title>New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin</article-title><source>Cancer Treat Rev</source><year>2009</year><volume>35</volume><fpage>57</fpage><lpage>68</lpage><pub-id pub-id-type="pmid">19004559</pub-id></element-citation></ref><ref id="ref17"><label>17</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Samarghandian</surname><given-names>S</given-names></name><name><surname>Afshari</surname><given-names>JT</given-names></name><name><surname>Davoodi</surname><given-names>S</given-names></name></person-group><article-title>Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3</article-title><source>Clinics (Sao Paulo)</source><year>2011</year><volume>66</volume><fpage>1073</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">21808878</pub-id></element-citation></ref><ref id="ref18"><label>18</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tundis</surname><given-names>R</given-names></name><name><surname>Loizzo</surname><given-names>MR</given-names></name><name><surname>Menichini</surname><given-names>F</given-names></name><name><surname>Bonesi</surname><given-names>M</given-names></name><name><surname>Colica</surname><given-names>C</given-names></name><name><surname>Menichini</surname><given-names>F</given-names></name></person-group><article-title><italic>In vitro</italic> cytotoxic activity of extracts and isolated constituents of Salvia leriifolia Benth. against a panel of human cancer cell lines</article-title><source>Chem Biodivers</source><year>2011</year><volume>8</volume><fpage>1152</fpage><lpage>62</lpage><pub-id pub-id-type="pmid">21674787</pub-id></element-citation></ref><ref id="ref19"><label>19</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kalim</surname><given-names>MD</given-names></name><name><surname>Bhattacharyya</surname><given-names>D</given-names></name><name><surname>Banerjee</surname><given-names>A</given-names></name><name><surname>Chattopadhyay</surname><given-names>S</given-names></name></person-group><article-title>Oxidative DNA damage preventive activity and antioxidant potential of plants used in Unani system of medicine</article-title><source>BMC Complement Altern Med</source><year>2010</year><volume>10</volume><fpage>77</fpage><pub-id pub-id-type="pmid">21159207</pub-id></element-citation></ref><ref id="ref20"><label>20</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>CZ</given-names></name><name><surname>Calway</surname><given-names>TD</given-names></name><name><surname>Wen</surname><given-names>XD</given-names></name><name><surname>Smith</surname><given-names>J</given-names></name><name><surname>Yu</surname><given-names>C</given-names></name><name><surname>Wang</surname><given-names>Y</given-names></name><etal></etal></person-group><article-title>Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway</article-title><source>Int J Oncol</source><year>2013</year><volume>42</volume><fpage>1018</fpage><lpage>26</lpage><pub-id pub-id-type="pmid">23337959</pub-id></element-citation></ref><ref id="ref21"><label>21</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Abrahim</surname><given-names>NN</given-names></name><name><surname>Kanthimathi</surname><given-names>MS</given-names></name><name><surname>Abdul-Aziz</surname><given-names>A</given-names></name></person-group><article-title>Piper betle shows antioxidant activities, inhibits MCF-7 cell proliferation and increases activities of catalase and superoxide dismutase</article-title><source>BMC Complement Altern Med</source><year>2012</year><volume>12</volume><fpage>220</fpage><pub-id pub-id-type="pmid">23153283</pub-id></element-citation></ref><ref id="ref22"><label>22</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hamedeyazdan</surname><given-names>S</given-names></name><name><surname>Fathiazad</surname><given-names>F</given-names></name><name><surname>Sharifi</surname><given-names>S</given-names></name><name><surname>Nazemiyeh</surname><given-names>H</given-names></name></person-group><article-title>Antiproliferative activity of Marrubium persicum extract in the MCF-7 human breast cancer cell line</article-title><source>Asian Pac J Cancer Prev</source><year>2012</year><volume>13</volume><fpage>5843</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">23317267</pub-id></element-citation></ref><ref id="ref23"><label>23</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Suttana</surname><given-names>W</given-names></name><name><surname>Mankhetkorn</surname><given-names>S</given-names></name><name><surname>Poompimon</surname><given-names>W</given-names></name><name><surname>Palagani</surname><given-names>A</given-names></name><name><surname>Zhokhov</surname><given-names>S</given-names></name><name><surname>Gerlo</surname><given-names>S</given-names></name><etal></etal></person-group><article-title>Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols</article-title><source>Mol Cancer</source><year>2010</year><volume>9</volume><fpage>99</fpage><pub-id pub-id-type="pmid">20438634</pub-id></element-citation></ref><ref id="ref24"><label>24</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kanno</surname><given-names>S</given-names></name><name><surname>Tomizawa</surname><given-names>A</given-names></name><name><surname>Hiura</surname><given-names>T</given-names></name><name><surname>Osanai</surname><given-names>Y</given-names></name><name><surname>Shouji</surname><given-names>A</given-names></name><name><surname>Ujibe</surname><given-names>M</given-names></name><etal></etal></person-group><article-title>Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180-implanted mice</article-title><source>Biol Pharm Bull</source><year>2005</year><volume>28</volume><fpage>527</fpage><lpage>30</lpage><pub-id pub-id-type="pmid">15744083</pub-id></element-citation></ref><ref id="ref25"><label>25</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bestwick</surname><given-names>CS</given-names></name><name><surname>Milne</surname><given-names>L</given-names></name></person-group><article-title>Influence of galangin on HL-60 cell proliferation and survival</article-title><source>Cancer Lett</source><year>2006</year><volume>243</volume><fpage>80</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">16413113</pub-id></element-citation></ref><ref id="ref26"><label>26</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Morales</surname><given-names>P</given-names></name><name><surname>Haza</surname><given-names>AI</given-names></name></person-group><article-title>Selective apoptotic effects of piceatannol and myricetin in human cancer cells</article-title><source>J Appl Toxicol</source><year>2012</year><volume>32</volume><fpage>986</fpage><lpage>93</lpage><pub-id pub-id-type="pmid">21935971</pub-id></element-citation></ref><ref id="ref27"><label>27</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chien</surname><given-names>CS</given-names></name><name><surname>Shen</surname><given-names>KH</given-names></name><name><surname>Huang</surname><given-names>JS</given-names></name><name><surname>Ko</surname><given-names>SC</given-names></name><name><surname>Shih</surname><given-names>YW</given-names></name></person-group><article-title>Antimetastatic potential of fisetin involves inactivation of the PI3K/Akt and JNK signaling pathways with downregulation of MMP-2/9 expressions in prostate cancer PC-3 cells</article-title><source>Mol Cell Biochem</source><year>2010</year><volume>333</volume><fpage>169</fpage><lpage>80</lpage><pub-id pub-id-type="pmid">19633975</pub-id></element-citation></ref><ref id="ref28"><label>28</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sato</surname><given-names>F</given-names></name><name><surname>Matsukawa</surname><given-names>Y</given-names></name><name><surname>Matsumoto</surname><given-names>K</given-names></name><name><surname>Nishino</surname><given-names>H</given-names></name><name><surname>Sakai</surname><given-names>T</given-names></name></person-group><article-title>Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells</article-title><source>Biochem Biophys Res Commun</source><year>1994</year><volume>204</volume><fpage>578</fpage><lpage>84</lpage><pub-id pub-id-type="pmid">7980517</pub-id></element-citation></ref><ref id="ref29"><label>29</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chung</surname><given-names>CS</given-names></name><name><surname>Jiang</surname><given-names>Y</given-names></name><name><surname>Cheng</surname><given-names>D</given-names></name><name><surname>Birt</surname><given-names>DF</given-names></name></person-group><article-title>Impact of adenomatous polyposis coli (APC) tumor supressor gene in human colon cancer cell lines on cell cycle arrest by apigenin</article-title><source>Mol Carcinog</source><year>2007</year><volume>46</volume><fpage>773</fpage><lpage>82</lpage><pub-id pub-id-type="pmid">17620292</pub-id></element-citation></ref><ref id="ref30"><label>30</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kilani-Jaziri</surname><given-names>S</given-names></name><name><surname>Frachet</surname><given-names>V</given-names></name><name><surname>Bhouri</surname><given-names>W</given-names></name><name><surname>Ghedira</surname><given-names>K</given-names></name><name><surname>Chekir-Ghedira</surname><given-names>L</given-names></name><name><surname>Ronot</surname><given-names>X</given-names></name></person-group><article-title>Flavones inhibit the proliferation of human tumor cancer cell lines by inducing apoptosis</article-title><source>Drug Chem Toxicol</source><year>2012</year><volume>35</volume><fpage>1</fpage><lpage>10</lpage><pub-id pub-id-type="pmid">21777131</pub-id></element-citation></ref><ref id="ref31"><label>31</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>EJ</given-names></name><name><surname>Oh</surname><given-names>SY</given-names></name><name><surname>Sung</surname><given-names>MK</given-names></name></person-group><article-title>Luteolin exerts anti-tumor activity through the suppression of epidermal growth factor receptor-mediated pathway in MDA-MB-231 ER-negative breast cancer cells</article-title><source>Food Chem Toxicol</source><year>2012</year><volume>50</volume><fpage>4136</fpage><lpage>43</lpage><pub-id pub-id-type="pmid">22926442</pub-id></element-citation></ref><ref id="ref32"><label>32</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bulzomi</surname><given-names>P</given-names></name><name><surname>Bolli</surname><given-names>A</given-names></name><name><surname>Galluzzo</surname><given-names>P</given-names></name><name><surname>Acconcia</surname><given-names>F</given-names></name><name><surname>Ascenzi</surname><given-names>P</given-names></name><name><surname>Marino</surname><given-names>M</given-names></name></person-group><article-title>The naringenin-induced proapoptotic effect in breast cancer cell lines holds out against a high nisphenol a background</article-title><source>IUBMB Life</source><year>2012</year><volume>64</volume><fpage>690</fpage><lpage>6</lpage><pub-id pub-id-type="pmid">22692793</pub-id></element-citation></ref><ref id="ref33"><label>33</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dai</surname><given-names>Z</given-names></name><name><surname>Nair</surname><given-names>V</given-names></name><name><surname>Khan</surname><given-names>M</given-names></name><name><surname>Ciolino</surname><given-names>HP</given-names></name></person-group><article-title>Pomegranate extract inhibits the proliferation and viability of MMTV-Wnt-1 mouse mammary cancer stem cells <italic>in vitro</italic></article-title><source>Oncol Rep</source><year>2010</year><volume>24</volume><fpage>1087</fpage><lpage>91</lpage><pub-id pub-id-type="pmid">20811693</pub-id></element-citation></ref><ref id="ref34"><label>34</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Morley</surname><given-names>KL</given-names></name><name><surname>Ferguson</surname><given-names>PJ</given-names></name><name><surname>Koropatnick</surname><given-names>J</given-names></name></person-group><article-title>Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells</article-title><source>Cancer Lett</source><year>2007</year><volume>251</volume><fpage>168</fpage><lpage>78</lpage><pub-id pub-id-type="pmid">17197076</pub-id></element-citation></ref><ref id="ref35"><label>35</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yin</surname><given-names>F</given-names></name><name><surname>Giuliano</surname><given-names>AE</given-names></name><name><surname>Law</surname><given-names>RE</given-names></name><name><surname>Van Herle</surname><given-names>AJ</given-names></name></person-group><article-title>Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells</article-title><source>Anticancer Res</source><year>2001</year><volume>21</volume><fpage>413</fpage><lpage>20</lpage><pub-id pub-id-type="pmid">11299771</pub-id></element-citation></ref><ref id="ref36"><label>36</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Takagaki</surname><given-names>N</given-names></name><name><surname>Sowa</surname><given-names>Y</given-names></name><name><surname>Oki</surname><given-names>T</given-names></name><name><surname>Nakanishi</surname><given-names>R</given-names></name><name><surname>Yogosawa</surname><given-names>S</given-names></name><name><surname>Sakai</surname><given-names>T</given-names></name></person-group><article-title>Apigenin induces cell cycle arrest and p21/WAF1 expression in a p53-independent pathway</article-title><source>Int J Oncol</source><year>2005</year><volume>26</volume><fpage>185</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">15586239</pub-id></element-citation></ref><ref id="ref37"><label>37</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pacifico</surname><given-names>S</given-names></name><name><surname>Scognamiglio</surname><given-names>M</given-names></name><name><surname>D’Abrosca</surname><given-names>B</given-names></name><name><surname>Piccolella</surname><given-names>S</given-names></name><name><surname>Tsafantakis</surname><given-names>N</given-names></name><name><surname>Gallicchio</surname><given-names>M</given-names></name><etal></etal></person-group><article-title>Spectroscopic characterization and antiproliferative activity on HepG2 human hepatoblastoma cells of flavonoid C-glycosides from Petrorhagia velutina</article-title><source>J Nat Prod</source><year>2010</year><volume>73</volume><fpage>1973</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">21080643</pub-id></element-citation></ref><ref id="ref38"><label>38</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jeong</surname><given-names>JC</given-names></name><name><surname>Kim</surname><given-names>MS</given-names></name><name><surname>Kim</surname><given-names>TH</given-names></name><name><surname>Kim</surname><given-names>YK</given-names></name></person-group><article-title>Kaempferol induces cell death through ERK and Akt-dependent down-regulation of XIAP and survivin in human glioma cells</article-title><source>Neurochem Res</source><year>2009</year><volume>34</volume><fpage>991</fpage><lpage>1001</lpage><pub-id pub-id-type="pmid">18949556</pub-id></element-citation></ref><ref id="ref39"><label>39</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kim</surname><given-names>DA</given-names></name><name><surname>Jeon</surname><given-names>YK</given-names></name><name><surname>Nam</surname><given-names>MJ</given-names></name></person-group><article-title>Galangin Induces apoptosis in gastric cancer cells via regulation of ubiquitin carboxy-terminal hydrolase isozyme L1 and glutathione S-transferase P</article-title><source>Food Chem Toxicol</source><year>2012</year><volume>50</volume><fpage>684</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">22142694</pub-id></element-citation></ref><ref id="ref40"><label>40</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Amado</surname><given-names>NG</given-names></name><name><surname>Cerqueira</surname><given-names>DM</given-names></name><name><surname>Menezes</surname><given-names>FS</given-names></name><name><surname>da Silva</surname><given-names>JF</given-names></name><name><surname>Neto</surname><given-names>VM</given-names></name><name><surname>Abreu</surname><given-names>JG</given-names></name></person-group><article-title>Isoquercitrin isolated from Hyptis fasciculata reduces glioblastoma cell proliferation and changes beta-catenin cellular localization</article-title><source>Anticancer Drugs</source><year>2009</year><volume>20</volume><fpage>543</fpage><lpage>52</lpage><pub-id pub-id-type="pmid">19491660</pub-id></element-citation></ref><ref id="ref41"><label>41</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>ER</given-names></name><name><surname>Kang</surname><given-names>YJ</given-names></name><name><surname>Choi</surname><given-names>HY</given-names></name><name><surname>Kang</surname><given-names>GH</given-names></name><name><surname>Kim</surname><given-names>JH</given-names></name><name><surname>Kim</surname><given-names>BW</given-names></name><etal></etal></person-group><article-title>Induction of apoptotic cell death by synthetic naringenin derivatives in human lung epithelial carcinoma A549 cells</article-title><source>Biol Pharm Bull</source><year>2007</year><volume>30</volume><fpage>2394</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">18057732</pub-id></element-citation></ref><ref id="ref42"><label>42</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shih</surname><given-names>YW</given-names></name><name><surname>Wu</surname><given-names>PF</given-names></name><name><surname>Lee</surname><given-names>YC</given-names></name><name><surname>Shi</surname><given-names>MD</given-names></name><name><surname>Chiang</surname><given-names>TA</given-names></name></person-group><article-title>Myricetin suppresses invasion and migration of human lung adenocarcinoma A549 cells: Possible mediation by blocking the ERK signaling pathway</article-title><source>J Agric Food Chem</source><year>2009</year><volume>57</volume><fpage>3490</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">19326946</pub-id></element-citation></ref><ref id="ref43"><label>43</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ninomiya</surname><given-names>M</given-names></name><name><surname>Nishida</surname><given-names>K</given-names></name><name><surname>Tanaka</surname><given-names>K</given-names></name><name><surname>Watanabe</surname><given-names>K</given-names></name><name><surname>Koketsu</surname><given-names>M</given-names></name></person-group><article-title>Structure-activity relationship studies of 5,7-dihydroxyflavones as naturally occurring inhibitors of cell proliferation in human leukemia HL-60 cells</article-title><source>J Nat Med</source><year>2013</year><volume>67</volume><fpage>460</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">22855403</pub-id></element-citation></ref><ref id="ref44"><label>44</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>BD</given-names></name><name><surname>Yang</surname><given-names>ZY</given-names></name><name><surname>Wang</surname><given-names>Q</given-names></name><name><surname>Cai</surname><given-names>TK</given-names></name><name><surname>Crewdson</surname><given-names>P</given-names></name></person-group><article-title>Synthesis, characterization, cytotoxic activities, and DNA-binding properties of the La(III) complex with Naringenin Schiff-base</article-title><source>Bioorg Med Chem</source><year>2006</year><volume>14</volume><fpage>1880</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">16310358</pub-id></element-citation></ref><ref id="ref45"><label>45</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lefort</surname><given-names>EC</given-names></name><name><surname>Blay</surname><given-names>J</given-names></name></person-group><article-title>Apigenin and its impact on gastrointestinal cancers</article-title><source>Mol Nutr Food Res</source><year>2013</year><volume>57</volume><fpage>126</fpage><lpage>44</lpage><pub-id pub-id-type="pmid">23197449</pub-id></element-citation></ref><ref id="ref46"><label>46</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>W</given-names></name><name><surname>VanAlstyne</surname><given-names>PC</given-names></name><name><surname>Irons</surname><given-names>KA</given-names></name><name><surname>Chen</surname><given-names>S</given-names></name><name><surname>Stewart</surname><given-names>JW</given-names></name><name><surname>Birt</surname><given-names>DF</given-names></name></person-group><article-title>Individual and interactive effects of apigenin analogs on G2/M cell-cycle arrest in human colon carcinoma cell lines</article-title><source>Nutr Cancer</source><year>2004</year><volume>48</volume><fpage>106</fpage><lpage>14</lpage><pub-id pub-id-type="pmid">15203384</pub-id></element-citation></ref><ref id="ref47"><label>47</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Patel</surname><given-names>D</given-names></name><name><surname>Shukla</surname><given-names>S</given-names></name><name><surname>Gupta</surname><given-names>S</given-names></name></person-group><article-title>Apigenin and cancer chemoprevention: Progress, potential and promise (review)</article-title><source>Int J Oncol</source><year>2007</year><volume>30</volume><fpage>233</fpage><lpage>45</lpage><pub-id pub-id-type="pmid">17143534</pub-id></element-citation></ref><ref id="ref48"><label>48</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Khoo</surname><given-names>BY</given-names></name><name><surname>Chua</surname><given-names>SL</given-names></name><name><surname>Balaram</surname><given-names>P</given-names></name></person-group><article-title>Apoptotic effects of chrysin in human cancer cell lines</article-title><source>Int J Mol Sci</source><year>2010</year><volume>11</volume><fpage>2188</fpage><lpage>99</lpage><pub-id pub-id-type="pmid">20559509</pub-id></element-citation></ref><ref id="ref49"><label>49</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>N</given-names></name><name><surname>Liu</surname><given-names>JH</given-names></name><name><surname>Zhang</surname><given-names>J</given-names></name><name><surname>Yu</surname><given-names>BY</given-names></name></person-group><article-title>Comparative evaluation of cytotoxicity and antioxidative activity of 20 flavonoids</article-title><source>J Agric Food Chem</source><year>2008</year><volume>56</volume><fpage>3876</fpage><lpage>83</lpage><pub-id pub-id-type="pmid">18433100</pub-id></element-citation></ref><ref id="ref50"><label>50</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Guthrie</surname><given-names>N</given-names></name><name><surname>Carroll</surname><given-names>KK</given-names></name></person-group><article-title>Inhibition of mammary cancer by citrus flavonoids</article-title><source>Adv Exp Med Biol</source><year>1998</year><volume>439</volume><fpage>227</fpage><lpage>36</lpage><pub-id pub-id-type="pmid">9781306</pub-id></element-citation></ref><ref id="ref51"><label>51</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Knowles</surname><given-names>LM</given-names></name><name><surname>Zigrossi</surname><given-names>DA</given-names></name><name><surname>Tauber</surname><given-names>RA</given-names></name><name><surname>Hightower</surname><given-names>C</given-names></name><name><surname>Milner</surname><given-names>JA</given-names></name></person-group><article-title>Flavonoids suppress androgen-independent human prostate tumor proliferation</article-title><source>Nutr Cancer</source><year>2000</year><volume>38</volume><fpage>116</fpage><lpage>22</lpage><pub-id pub-id-type="pmid">11341036</pub-id></element-citation></ref><ref id="ref52"><label>52</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Torkin</surname><given-names>R</given-names></name><name><surname>Lavoie</surname><given-names>JF</given-names></name><name><surname>Kaplan</surname><given-names>DR</given-names></name><name><surname>Yeger</surname><given-names>H</given-names></name></person-group><article-title>Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma</article-title><source>Mol Cancer Ther</source><year>2005</year><volume>4</volume><fpage>1</fpage><lpage>11</lpage><pub-id pub-id-type="pmid">15657348</pub-id></element-citation></ref><ref id="ref53"><label>53</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yoshimizu</surname><given-names>N</given-names></name><name><surname>Otani</surname><given-names>Y</given-names></name><name><surname>Saikawa</surname><given-names>Y</given-names></name><name><surname>Kubota</surname><given-names>T</given-names></name><name><surname>Yoshida</surname><given-names>M</given-names></name><name><surname>Furukawa</surname><given-names>T</given-names></name><etal></etal></person-group><article-title>Anti-tumour effects of nobiletin, a citrus flavonoid, on gastric cancer include: Antiproliferative effects, induction of apoptosis and cell cycle deregulation</article-title><source>Aliment Pharmacol Ther</source><year>2004</year><volume>20</volume><fpage>95</fpage><lpage>101</lpage><pub-id pub-id-type="pmid">15298613</pub-id></element-citation></ref><ref id="ref54"><label>54</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fotsis</surname><given-names>T</given-names></name><name><surname>Pepper</surname><given-names>MS</given-names></name><name><surname>Aktas</surname><given-names>E</given-names></name><name><surname>Breit</surname><given-names>S</given-names></name><name><surname>Rasku</surname><given-names>S</given-names></name><name><surname>Adlercreutz</surname><given-names>H</given-names></name><etal></etal></person-group><article-title>Flavonoids, dietary-derived inhibitors of cell proliferation and <italic>in vitro</italic> angiogenesis</article-title><source>Cancer Res</source><year>1997</year><volume>57</volume><fpage>2916</fpage><lpage>21</lpage><pub-id pub-id-type="pmid">9230201</pub-id></element-citation></ref><ref id="ref55"><label>55</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fotsis</surname><given-names>T</given-names></name><name><surname>Pepper</surname><given-names>MS</given-names></name><name><surname>Montesano</surname><given-names>R</given-names></name><name><surname>Aktas</surname><given-names>E</given-names></name><name><surname>Breit</surname><given-names>S</given-names></name><name><surname>Schweigerer</surname><given-names>L</given-names></name><etal></etal></person-group><article-title>Phytoestrogens and inhibition of angiogenesis</article-title><source>Baillieres Clin Endocrinol Metab</source><year>1998</year><volume>12</volume><fpage>649</fpage><lpage>66</lpage><pub-id pub-id-type="pmid">10384818</pub-id></element-citation></ref><ref id="ref56"><label>56</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lim do</surname><given-names>Y</given-names></name><name><surname>Jeong</surname><given-names>Y</given-names></name><name><surname>Tyner</surname><given-names>AL</given-names></name><name><surname>Park</surname><given-names>JH</given-names></name></person-group><article-title>Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin</article-title><source>Am J Physiol Gastrointest Liver Physiol</source><year>2007</year><volume>292</volume><fpage>G66</fpage><lpage>75</lpage><pub-id pub-id-type="pmid">16901994</pub-id></element-citation></ref><ref id="ref57"><label>57</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gupta</surname><given-names>S</given-names></name><name><surname>Afaq</surname><given-names>F</given-names></name><name><surname>Mukhtar</surname><given-names>H</given-names></name></person-group><article-title>Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells</article-title><source>Biochem Biophys Res Commun</source><year>2001</year><volume>287</volume><fpage>914</fpage><lpage>20</lpage><pub-id pub-id-type="pmid">11573952</pub-id></element-citation></ref><ref id="ref58"><label>58</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yuan</surname><given-names>E</given-names></name><name><surname>Liu</surname><given-names>B</given-names></name><name><surname>Ning</surname><given-names>Z</given-names></name><name><surname>Chen</surname><given-names>C</given-names></name></person-group><article-title>Preparative separation of flavonoids in Adinandra nitida leaves by high-speed counter-current chromatography and their effects on human epidermal carcinoma cancer cells</article-title><source>Food Chem</source><year>2009</year><volume>115</volume><fpage>1158</fpage><lpage>63</lpage></element-citation></ref><ref id="ref59"><label>59</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tokalov</surname><given-names>SV</given-names></name><name><surname>Abramyuk</surname><given-names>AM</given-names></name><name><surname>Abolmaali</surname><given-names>ND</given-names></name></person-group><article-title>Protection of p53 wild type cells from taxol by genistein in the combined treatment of lung cancer</article-title><source>Nutr Cancer</source><year>2010</year><volume>62</volume><fpage>795</fpage><lpage>801</lpage><pub-id pub-id-type="pmid">20661829</pub-id></element-citation></ref><ref id="ref60"><label>60</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Plochmann</surname><given-names>K</given-names></name><name><surname>Korte</surname><given-names>G</given-names></name><name><surname>Koutsilieri</surname><given-names>E</given-names></name><name><surname>Richling</surname><given-names>E</given-names></name><name><surname>Riederer</surname><given-names>P</given-names></name><name><surname>Rethwilm</surname><given-names>A</given-names></name><etal></etal></person-group><article-title>Structure-activity relationships of flavonoid-induced cytotoxicity on human leukemia cells</article-title><source>Arch Biochem Biophys</source><year>2007</year><volume>460</volume><fpage>1</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">17353006</pub-id></element-citation></ref><ref id="ref61"><label>61</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ben Sghaier</surname><given-names>M</given-names></name><name><surname>Skandrani</surname><given-names>I</given-names></name><name><surname>Nasr</surname><given-names>N</given-names></name><name><surname>Franca</surname><given-names>MG</given-names></name><name><surname>Chekir-Ghedira</surname><given-names>L</given-names></name><name><surname>Ghedira</surname><given-names>K</given-names></name></person-group><article-title>Flavonoids and sesquiterpenes from Tecurium ramosissimum promote antiproliferation of human cancer cells and enhance antioxidant activity: A structure-activity relationship study</article-title><source>Environ Toxicol Pharmacol</source><year>2011</year><volume>32</volume><fpage>336</fpage><lpage>48</lpage><pub-id pub-id-type="pmid">22004952</pub-id></element-citation></ref><ref id="ref62"><label>62</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hirano</surname><given-names>T</given-names></name><name><surname>Abe</surname><given-names>K</given-names></name><name><surname>Gotoh</surname><given-names>M</given-names></name><name><surname>Oka</surname><given-names>K</given-names></name></person-group><article-title>Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes</article-title><source>Br J Cancer</source><year>1995</year><volume>72</volume><fpage>1380</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">8519648</pub-id></element-citation></ref><ref id="ref63"><label>63</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chiu</surname><given-names>FL</given-names></name><name><surname>Lin</surname><given-names>JK</given-names></name></person-group><article-title>Downregulation of androgen receptor expression by luteolin causes inhibition of cell proliferation and induction of apoptosis in human prostate cancer cells and xenografts</article-title><source>Prostate</source><year>2008</year><volume>68</volume><fpage>61</fpage><lpage>71</lpage><pub-id pub-id-type="pmid">18008333</pub-id></element-citation></ref><ref id="ref64"><label>64</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Galvez</surname><given-names>M</given-names></name><name><surname>Martin-Cordero</surname><given-names>C</given-names></name><name><surname>Lopez-Lazaro</surname><given-names>M</given-names></name><name><surname>Cortes</surname><given-names>F</given-names></name><name><surname>Ayuso</surname><given-names>MJ</given-names></name></person-group><article-title>Cytotoxic effect of Plantago spp. on cancer cell lines</article-title><source>J Ethnopharmacol</source><year>2003</year><volume>88</volume><fpage>125</fpage><lpage>30</lpage><pub-id pub-id-type="pmid">12963131</pub-id></element-citation></ref><ref id="ref65"><label>65</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Choi</surname><given-names>EJ</given-names></name></person-group><article-title>Hesperetin induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: Involvement of CDK4 and p21</article-title><source>Nutr Cancer</source><year>2007</year><volume>59</volume><fpage>115</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">17927510</pub-id></element-citation></ref><ref id="ref66"><label>66</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chan</surname><given-names>FL</given-names></name><name><surname>Choi</surname><given-names>HL</given-names></name><name><surname>Chen</surname><given-names>ZY</given-names></name><name><surname>Chan</surname><given-names>PS</given-names></name><name><surname>Huang</surname><given-names>Y</given-names></name></person-group><article-title>Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin</article-title><source>Cancer Lett</source><year>2000</year><volume>160</volume><fpage>219</fpage><lpage>28</lpage><pub-id pub-id-type="pmid">11053652</pub-id></element-citation></ref><ref id="ref67"><label>67</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Androutsopoulos</surname><given-names>VP</given-names></name><name><surname>Ruparelia</surname><given-names>K</given-names></name><name><surname>Arroo</surname><given-names>RR</given-names></name><name><surname>Tsatsakis</surname><given-names>AM</given-names></name><name><surname>Spandidos</surname><given-names>DA</given-names></name></person-group><article-title>CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells</article-title><source>Toxicology</source><year>2009</year><volume>264</volume><fpage>162</fpage><lpage>70</lpage><pub-id pub-id-type="pmid">19666078</pub-id></element-citation></ref><ref id="ref68"><label>68</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Seelinger</surname><given-names>G</given-names></name><name><surname>Merfort</surname><given-names>I</given-names></name><name><surname>Wölfle</surname><given-names>U</given-names></name><name><surname>Schempp</surname><given-names>CM</given-names></name></person-group><article-title>Anti-carcinogenic effects of the flavonoid luteolin</article-title><source>Molecules</source><year>2008</year><volume>13</volume><fpage>2628</fpage><lpage>51</lpage><pub-id pub-id-type="pmid">18946424</pub-id></element-citation></ref><ref id="ref69"><label>69</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Benavente-Garcia</surname><given-names>O</given-names></name><name><surname>Castillo</surname><given-names>J</given-names></name></person-group><article-title>Update on uses and properties of citrus flavonoids: New findings in anticancer, cardiovascular, and anti-inflammatory activity</article-title><source>J Agric Food Chem</source><year>2008</year><volume>56</volume><fpage>6185</fpage><lpage>205</lpage><pub-id pub-id-type="pmid">18593176</pub-id></element-citation></ref><ref id="ref70"><label>70</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wätjen</surname><given-names>W</given-names></name><name><surname>Weber</surname><given-names>N</given-names></name><name><surname>Lou</surname><given-names>YJ</given-names></name><name><surname>Wang</surname><given-names>ZQ</given-names></name><name><surname>Chovolou</surname><given-names>Y</given-names></name><name><surname>Kampkötter</surname><given-names>A</given-names></name><etal></etal></person-group><article-title>Prenylation enhances cytotoxicity of apigenin and liquiritigenin in rat H4IIE hepatoma and C6 glioma cells</article-title><source>Food Chem Toxicol</source><year>2007</year><volume>45</volume><fpage>119</fpage><lpage>24</lpage><pub-id pub-id-type="pmid">17045382</pub-id></element-citation></ref><ref id="ref71"><label>71</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cai</surname><given-names>X</given-names></name><name><surname>Ye</surname><given-names>T</given-names></name><name><surname>Liu</surname><given-names>C</given-names></name><name><surname>Lu</surname><given-names>W</given-names></name><name><surname>Lu</surname><given-names>M</given-names></name><name><surname>Zhang</surname><given-names>J</given-names></name><etal></etal></person-group><article-title>Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells</article-title><source>Toxicol <italic>In Vitro</italic></source><year>2011</year><volume>25</volume><fpage>1385</fpage><lpage>91</lpage><pub-id pub-id-type="pmid">21601631</pub-id></element-citation></ref><ref id="ref72"><label>72</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhang</surname><given-names>Y</given-names></name><name><surname>Chen</surname><given-names>AY</given-names></name><name><surname>Li</surname><given-names>M</given-names></name><name><surname>Chen</surname><given-names>C</given-names></name><name><surname>Yao</surname><given-names>Q</given-names></name></person-group><article-title>Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells</article-title><source>J Surg Res</source><year>2008</year><volume>148</volume><fpage>17</fpage><lpage>23</lpage><pub-id pub-id-type="pmid">18570926</pub-id></element-citation></ref><ref id="ref73"><label>73</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Xu</surname><given-names>XF</given-names></name><name><surname>Cai</surname><given-names>BL</given-names></name><name><surname>Guan</surname><given-names>SM</given-names></name><name><surname>Li</surname><given-names>Y</given-names></name><name><surname>Wu</surname><given-names>JZ</given-names></name><name><surname>Wang</surname><given-names>Y</given-names></name><etal></etal></person-group><article-title>Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis <italic>in vitro</italic> and <italic>in vivo</italic></article-title><source>Invest New Drugs</source><year>2011</year><volume>29</volume><fpage>637</fpage><lpage>45</lpage><pub-id pub-id-type="pmid">20204673</pub-id></element-citation></ref><ref id="ref74"><label>74</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>WR</given-names></name><name><surname>Shen</surname><given-names>SC</given-names></name><name><surname>Lin</surname><given-names>HY</given-names></name><name><surname>Hou</surname><given-names>WC</given-names></name><name><surname>Yang</surname><given-names>LL</given-names></name><name><surname>Chen</surname><given-names>YC</given-names></name></person-group><article-title>Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease</article-title><source>Biochem Pharmacol</source><year>2002</year><volume>63</volume><fpage>225</fpage><lpage>36</lpage><pub-id pub-id-type="pmid">11841797</pub-id></element-citation></ref><ref id="ref75"><label>75</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Park</surname><given-names>JH</given-names></name><name><surname>Jin</surname><given-names>CY</given-names></name><name><surname>Lee</surname><given-names>BK</given-names></name><name><surname>Kim</surname><given-names>GY</given-names></name><name><surname>Choi</surname><given-names>YH</given-names></name><name><surname>Jeong</surname><given-names>YK</given-names></name></person-group><article-title>Naringenin induces apoptosis through downregulation of Akt and caspase-3 activation in human leukemia THP-1 cells</article-title><source>Food Chem Toxicol</source><year>2008</year><volume>46</volume><fpage>3684</fpage><lpage>90</lpage><pub-id pub-id-type="pmid">18930780</pub-id></element-citation></ref><ref id="ref76"><label>76</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Anter</surname><given-names>J</given-names></name><name><surname>Romero-Jimenez</surname><given-names>M</given-names></name><name><surname>Fernandez-Badmar</surname><given-names>Z</given-names></name><name><surname>Villatoro-Pulido</surname><given-names>M</given-names></name><name><surname>Analla</surname><given-names>M</given-names></name><name><surname>Alonso-Moraga</surname><given-names>A</given-names></name><name><surname>et</surname><given-names>al0</given-names></name></person-group><article-title>Antigenotoxicity, cytotoxicity, and apoptosis induction by apigenin, bisabolol, and protocatechuic acid</article-title><source>J Med Food</source><year>2011</year><volume>14</volume><fpage>276</fpage><lpage>83</lpage><pub-id pub-id-type="pmid">21182433</pub-id></element-citation></ref><ref id="ref77"><label>77</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Choi</surname><given-names>EJ</given-names></name><name><surname>Kim</surname><given-names>GH</given-names></name></person-group><article-title>Apigenin causes G(2)/M arrest associated with the modulation of p21(Cip1) and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells</article-title><source>J Nutr Biochem</source><year>2009</year><volume>20</volume><fpage>285</fpage><lpage>90</lpage><pub-id pub-id-type="pmid">18656338</pub-id></element-citation></ref><ref id="ref78"><label>78</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kajimoto</surname><given-names>S</given-names></name><name><surname>Takanashi</surname><given-names>N</given-names></name><name><surname>Kajimoto</surname><given-names>T</given-names></name><name><surname>Xu</surname><given-names>M</given-names></name><name><surname>Cao</surname><given-names>J</given-names></name><name><surname>Masuda</surname><given-names>Y</given-names></name><etal></etal></person-group><article-title>Sophoranone, extracted from a traditional Chinese medicine Shan Dou Gen, induces apoptosis in human leukemia U937 cells via formation of reactive oxygen species and opening of mitochondrial permeability transition pores</article-title><source>Int J Cancer</source><year>2002</year><volume>99</volume><fpage>879</fpage><lpage>90</lpage><pub-id pub-id-type="pmid">12115492</pub-id></element-citation></ref><ref id="ref79"><label>79</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lin</surname><given-names>CC</given-names></name><name><surname>Kuo</surname><given-names>CL</given-names></name><name><surname>Lee</surname><given-names>MH</given-names></name><name><surname>Lai</surname><given-names>KC</given-names></name><name><surname>Lin</surname><given-names>JP</given-names></name><name><surname>Yang</surname><given-names>JS</given-names></name><etal></etal></person-group><article-title>Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways</article-title><source>Int J Oncol</source><year>2011</year><volume>39</volume><fpage>217</fpage><lpage>24</lpage><pub-id pub-id-type="pmid">21573491</pub-id></element-citation></ref><ref id="ref80"><label>80</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fu</surname><given-names>J</given-names></name><name><surname>Chen</surname><given-names>D</given-names></name><name><surname>Zhao</surname><given-names>B</given-names></name><name><surname>Zhao</surname><given-names>Z</given-names></name><name><surname>Zhou</surname><given-names>J</given-names></name><name><surname>Xu</surname><given-names>J</given-names></name><etal></etal></person-group><article-title>Luteolin induces carcinoma cell apoptosis through binding Hsp90 to suppress constitutive activation of STAT3</article-title><source>PloS One</source><year>2012</year><fpage>e49194</fpage><pub-id pub-id-type="pmid">23145121</pub-id></element-citation></ref><ref id="ref81"><label>81</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jeong</surname><given-names>JH</given-names></name><name><surname>An</surname><given-names>JY</given-names></name><name><surname>Kwon</surname><given-names>YT</given-names></name><name><surname>Rhee</surname><given-names>JG</given-names></name><name><surname>Lee</surname><given-names>YJ</given-names></name></person-group><article-title>Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression</article-title><source>J Cell Biochem</source><year>2009</year><volume>106</volume><fpage>73</fpage><lpage>82</lpage><pub-id pub-id-type="pmid">19009557</pub-id></element-citation></ref><ref id="ref82"><label>82</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lu</surname><given-names>X</given-names></name><name><surname>Jung</surname><given-names>Ji</given-names></name><name><surname>Cho</surname><given-names>HJ</given-names></name><name><surname>Lim</surname><given-names>DY</given-names></name><name><surname>Lee</surname><given-names>HS</given-names></name><name><surname>Chun</surname><given-names>HS</given-names></name><etal></etal></person-group><article-title>Fisetin inhibits the activities of cyclin-dependent kinases leading to cell cycle arrest in HT-29 human colon cancer cells</article-title><source>J Nutr</source><year>2005</year><volume>135</volume><fpage>2884</fpage><lpage>90</lpage><pub-id pub-id-type="pmid">16317137</pub-id></element-citation></ref><ref id="ref83"><label>83</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shukla</surname><given-names>S</given-names></name><name><surname>Gupta</surname><given-names>S</given-names></name></person-group><article-title>Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells</article-title><source>Cell Cycle</source><year>2007</year><volume>6</volume><fpage>1102</fpage><lpage>14</lpage><pub-id pub-id-type="pmid">17457054</pub-id></element-citation></ref><ref id="ref84"><label>84</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Koide</surname><given-names>T</given-names></name><name><surname>Kamei</surname><given-names>H</given-names></name><name><surname>Hashimoto</surname><given-names>Y</given-names></name><name><surname>Kojima</surname><given-names>T</given-names></name><name><surname>Terabe</surname><given-names>K</given-names></name><name><surname>Umeda</surname><given-names>T</given-names></name></person-group><article-title>Influence of flavonoids on cell cycle phase as analyzed by flow-cytometry</article-title><source>Cancer Biother Radiopharm</source><year>1997</year><volume>12</volume><fpage>111</fpage><lpage>5</lpage><pub-id pub-id-type="pmid">10851454</pub-id></element-citation></ref><ref id="ref85"><label>85</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Neves</surname><given-names>MP</given-names></name><name><surname>Cidade</surname><given-names>H</given-names></name><name><surname>Pinto</surname><given-names>M</given-names></name><name><surname>Silva</surname><given-names>AM</given-names></name><name><surname>Gales</surname><given-names>L</given-names></name><name><surname>Damas</surname><given-names>AM</given-names></name><etal></etal></person-group><article-title>Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: Synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis</article-title><source>Eur J Med Chem</source><year>2011</year><volume>46</volume><fpage>2562</fpage><lpage>74</lpage><pub-id pub-id-type="pmid">21496973</pub-id></element-citation></ref><ref id="ref86"><label>86</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Leung</surname><given-names>HW</given-names></name><name><surname>Lin</surname><given-names>CJ</given-names></name><name><surname>Hour</surname><given-names>MJ</given-names></name><name><surname>Yang</surname><given-names>WH</given-names></name><name><surname>Wang</surname><given-names>MY</given-names></name><name><surname>Lee</surname><given-names>HZ</given-names></name></person-group><article-title>Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes</article-title><source>Food Chem Toxicol</source><year>2007</year><volume>45</volume><fpage>2005</fpage><lpage>13</lpage><pub-id pub-id-type="pmid">17583406</pub-id></element-citation></ref><ref id="ref87"><label>87</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Habtemarium</surname><given-names>S</given-names></name><name><surname>Dagne</surname><given-names>E</given-names></name></person-group><article-title>Comparative antioxidant, prooxidant and cytotoxic activity of sigmoidin A and eriodictyol</article-title><source>Planta Med</source><year>2010</year><volume>76</volume><fpage>589</fpage><lpage>94</lpage><pub-id pub-id-type="pmid">19941260</pub-id></element-citation></ref><ref id="ref88"><label>88</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Valdameri</surname><given-names>G</given-names></name><name><surname>Trombetta-Lima</surname><given-names>M</given-names></name><name><surname>Worfel</surname><given-names>PR</given-names></name><name><surname>Pires</surname><given-names>AR</given-names></name><name><surname>Martinez</surname><given-names>GR</given-names></name><name><surname>Noleto</surname><given-names>GR</given-names></name><etal></etal></person-group><article-title>Involvement of catalase in the apoptotic mechanism induced by apigenin in HepG2 human hepatoma cells</article-title><source>Chem Biol Interact</source><year>2011</year><volume>193</volume><fpage>180</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">21756884</pub-id></element-citation></ref><ref id="ref89"><label>89</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yuan</surname><given-names>L</given-names></name><name><surname>Wang</surname><given-names>J</given-names></name><name><surname>Xiao</surname><given-names>H</given-names></name><name><surname>Xiao</surname><given-names>C</given-names></name><name><surname>Wang</surname><given-names>Y</given-names></name><name><surname>Liu</surname><given-names>X</given-names></name></person-group><article-title>Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells</article-title><source>Toxicol Appl Pharmacol</source><year>2012</year><volume>265</volume><fpage>83</fpage><lpage>92</lpage><pub-id pub-id-type="pmid">23026832</pub-id></element-citation></ref><ref id="ref90"><label>90</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Xu</surname><given-names>Y</given-names></name><name><surname>Xin</surname><given-names>Y</given-names></name><name><surname>Diao</surname><given-names>Y</given-names></name><name><surname>Lu</surname><given-names>C</given-names></name><name><surname>Fu</surname><given-names>J</given-names></name><name><surname>Luo</surname><given-names>L</given-names></name><etal></etal></person-group><article-title>Synergistic effects of apigenin and paclitaxel on apoptosis of cancer cells</article-title><source>PLoS One</source><year>2011</year><volume>6</volume><fpage>e29169</fpage><pub-id pub-id-type="pmid">22216199</pub-id></element-citation></ref><ref id="ref91"><label>91</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tsai</surname><given-names>CF</given-names></name><name><surname>Yeh</surname><given-names>WL</given-names></name><name><surname>Huang</surname><given-names>SM</given-names></name><name><surname>Tan</surname><given-names>TW</given-names></name><name><surname>Lu</surname><given-names>DY</given-names></name></person-group><article-title>Wogonin induces reactive oxygen species production and cell apoptosis in human glioma cancer cells</article-title><source>Int J Mol Sci</source><year>2012</year><volume>13</volume><fpage>9877</fpage><lpage>92</lpage><pub-id pub-id-type="pmid">22949836</pub-id></element-citation></ref><ref id="ref92"><label>92</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Matsuo</surname><given-names>M</given-names></name><name><surname>Sasaki</surname><given-names>N</given-names></name><name><surname>Saga</surname><given-names>K</given-names></name><name><surname>Kaneko</surname><given-names>T</given-names></name></person-group><article-title>Cytotoxicity of flavonoids toward cultured normal human cells</article-title><source>Biol Pharm Bull</source><year>2005</year><volume>28</volume><fpage>253</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">15684479</pub-id></element-citation></ref><ref id="ref93"><label>93</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Agullo</surname><given-names>G</given-names></name><name><surname>Gamet-Payrastre</surname><given-names>L</given-names></name><name><surname>Fernandez</surname><given-names>Y</given-names></name><name><surname>Anciaux</surname><given-names>N</given-names></name><name><surname>Demigne</surname><given-names>C</given-names></name><name><surname>Rémésy</surname><given-names>C</given-names></name></person-group><article-title>Comparative effects of flavonoids on the growth, viability and metabolism of a colonic adenocarcinoma cell line (HT29 cells)</article-title><source>Cancer Lett</source><year>1996</year><volume>105</volume><fpage>61</fpage><lpage>70</lpage><pub-id pub-id-type="pmid">8689634</pub-id></element-citation></ref><ref id="ref94"><label>94</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>KW</given-names></name><name><surname>Hur</surname><given-names>HJ</given-names></name><name><surname>Lee</surname><given-names>HJ</given-names></name><name><surname>Lee</surname><given-names>CY</given-names></name></person-group><article-title>Antiproliferative effects of dietary phenolic substances and hydrogen peroxide</article-title><source>J Agric Food Chem</source><year>2005</year><volume>53</volume><fpage>1990</fpage><lpage>5</lpage><pub-id pub-id-type="pmid">15769125</pub-id></element-citation></ref><ref id="ref95"><label>95</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Talib</surname><given-names>WH</given-names></name><name><surname>Zarga</surname><given-names>MH</given-names></name><name><surname>Mahasneh</surname><given-names>AM</given-names></name></person-group><article-title>Antiproliferative, antimicrobial and apoptosis inducing effects of compounds isolated from inula viscosa</article-title><source>Molecules</source><year>2012</year><volume>17</volume><fpage>3291</fpage><lpage>303</lpage><pub-id pub-id-type="pmid">22418930</pub-id></element-citation></ref><ref id="ref96"><label>96</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Benavente-Garcia</surname><given-names>O</given-names></name><name><surname>Castillo</surname><given-names>J</given-names></name><name><surname>Lorente</surname><given-names>J</given-names></name><name><surname>Alcaraz</surname><given-names>M</given-names></name><name><surname>Yanez</surname><given-names>J</given-names></name><name><surname>Martinez</surname><given-names>C</given-names></name><etal></etal></person-group><article-title>Antiproliferative activity of several phenolic compounds against melanoma cell lines: Relationship between structure and activity</article-title><source>Agro Food Ind Hi-Tech</source><year>2005</year><volume>16</volume><fpage>30</fpage><lpage>4</lpage></element-citation></ref><ref id="ref97"><label>97</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rodriguez</surname><given-names>J</given-names></name><name><surname>Yanez</surname><given-names>J</given-names></name><name><surname>Vicente</surname><given-names>V</given-names></name><name><surname>Alcaraz</surname><given-names>M</given-names></name><name><surname>Benavente-Garcia</surname><given-names>O</given-names></name><name><surname>Castillo</surname><given-names>J</given-names></name><etal></etal></person-group><article-title>Effects of several flavonoids on the growth of B16F10 and SK-MEL-1 melanoma cell lines: Relationship between structure and activity</article-title><source>Melanoma Res</source><year>2002</year><volume>12</volume><fpage>99</fpage><lpage>107</lpage><pub-id pub-id-type="pmid">11930105</pub-id></element-citation></ref><ref id="ref98"><label>98</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ragazzon</surname><given-names>PA</given-names></name><name><surname>Bradshaw</surname><given-names>T</given-names></name><name><surname>Matthews</surname><given-names>C</given-names></name><name><surname>Iley</surname><given-names>J</given-names></name><name><surname>Missailidis</surname><given-names>S</given-names></name></person-group><article-title>The characterisation of flavone-DNA isoform interactions as a basis for anticancer drug development</article-title><source>Anticancer Res</source><year>2009</year><volume>29</volume><fpage>2273</fpage><lpage>83</lpage><pub-id pub-id-type="pmid">19528492</pub-id></element-citation></ref><ref id="ref99"><label>99</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mamadalieva</surname><given-names>NZ</given-names></name><name><surname>Herrmann</surname><given-names>F</given-names></name><name><surname>El-Readi</surname><given-names>MZ</given-names></name><name><surname>Tahrani</surname><given-names>A</given-names></name><name><surname>Hamoud</surname><given-names>R</given-names></name><name><surname>Egamberdieva</surname><given-names>DR</given-names></name><etal></etal></person-group><article-title>Flavonoids in Scutellaria immaculata and S. ramosissima (Lamiaceae) and their biological activity</article-title><source>J Pharm Pharmacol</source><year>2011</year><volume>63</volume><fpage>1346</fpage><lpage>57</lpage><pub-id pub-id-type="pmid">21899551</pub-id></element-citation></ref><ref id="ref100"><label>100</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rao</surname><given-names>PS</given-names></name><name><surname>Satelli</surname><given-names>A</given-names></name><name><surname>Moridani</surname><given-names>M</given-names></name><name><surname>Jenkins</surname><given-names>M</given-names></name><name><surname>Rao</surname><given-names>US</given-names></name></person-group><article-title>Luteolin induces apoptosis in multidrug resistant cancer cells without affecting the drug transporter function: Involvement of cell line-specific apoptotic mechanisms</article-title><source>Int J Cancer</source><year>2012</year><volume>130</volume><fpage>2703</fpage><lpage>14</lpage><pub-id pub-id-type="pmid">21792893</pub-id></element-citation></ref><ref id="ref101"><label>101</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Androutsopoulos</surname><given-names>VP</given-names></name><name><surname>Spandidos</surname><given-names>DA</given-names></name></person-group><article-title>The flavonoids diosmetin and luteolin exert synergistic cytostatic effects in human hepatoma HepG2 cells via CYP1A-catalyzed metabolism, activation of JNK and ERK and P53/P21 up-regulation</article-title><source>J Nutr Biochem</source><year>2013</year><volume>24</volume><fpage>496</fpage><lpage>504</lpage><pub-id pub-id-type="pmid">22749133</pub-id></element-citation></ref><ref id="ref102"><label>102</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jin</surname><given-names>CY</given-names></name><name><surname>Park</surname><given-names>C</given-names></name><name><surname>Lee</surname><given-names>JH</given-names></name><name><surname>Chung</surname><given-names>KT</given-names></name><name><surname>Kwon</surname><given-names>TK</given-names></name><name><surname>Kim</surname><given-names>GY</given-names></name><etal></etal></person-group><article-title>Naringenin-induced apoptosis is attenuated by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human leukemia U937 cells</article-title><source>Toxicol <italic>In Vitro</italic></source><year>2009</year><volume>23</volume><fpage>259</fpage><lpage>65</lpage><pub-id pub-id-type="pmid">19124070</pub-id></element-citation></ref><ref id="ref103"><label>103</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Harmon</surname><given-names>AW</given-names></name><name><surname>Patel</surname><given-names>YM</given-names></name></person-group><article-title>Naringenin inhibits glucose uptake in MCF-7 breast cancer cells: A mechanism for impaired cellular proliferation</article-title><source>Breast Cancer Res Treat</source><year>2004</year><volume>85</volume><fpage>103</fpage><lpage>10</lpage><pub-id pub-id-type="pmid">15111768</pub-id></element-citation></ref><ref id="ref104"><label>104</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yang</surname><given-names>Y</given-names></name><name><surname>Wolfram</surname><given-names>J</given-names></name><name><surname>Boom</surname><given-names>K</given-names></name><name><surname>Fang</surname><given-names>X</given-names></name><name><surname>Shen</surname><given-names>H</given-names></name><name><surname>Ferrari</surname><given-names>M</given-names></name></person-group><article-title>Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells</article-title><source>Cell Biochem Funct</source><year>2013</year><volume>31</volume><fpage>374</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">23042260</pub-id></element-citation></ref><ref id="ref105"><label>105</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pandey</surname><given-names>M</given-names></name><name><surname>Kaur</surname><given-names>P</given-names></name><name><surname>Shukla</surname><given-names>S</given-names></name><name><surname>Abbas</surname><given-names>A</given-names></name><name><surname>Fu</surname><given-names>P</given-names></name><name><surname>Gupta</surname><given-names>S</given-names></name></person-group><article-title>Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: <italic>In vitro</italic> and <italic>in vivo</italic> study</article-title><source>Mol Carcinog</source><year>2012</year><volume>51</volume><fpage>952</fpage><lpage>62</lpage><pub-id pub-id-type="pmid">22006862</pub-id></element-citation></ref><ref id="ref106"><label>106</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Luo</surname><given-names>H</given-names></name><name><surname>Jiang</surname><given-names>B</given-names></name><name><surname>Li</surname><given-names>B</given-names></name><name><surname>Li</surname><given-names>Z</given-names></name><name><surname>Jiang</surname><given-names>BH</given-names></name><name><surname>Chen</surname><given-names>YC</given-names></name></person-group><article-title>Kaempferol nanoparticles achieve strong and selective inhibition of ovarian cancer cell viability</article-title><source>Int J Nanomedicine</source><year>2012</year><volume>7</volume><fpage>3951</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">22866004</pub-id></element-citation></ref><ref id="ref107"><label>107</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Xiao</surname><given-names>H</given-names></name><name><surname>Yang</surname><given-names>CS</given-names></name><name><surname>Li</surname><given-names>S</given-names></name><name><surname>Jin</surname><given-names>H</given-names></name><name><surname>Ho</surname><given-names>CT</given-names></name><name><surname>Patel</surname><given-names>T</given-names></name></person-group><article-title>Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis</article-title><source>Mol Nutr Food Res</source><year>2009</year><volume>53</volume><fpage>398</fpage><lpage>406</lpage><pub-id pub-id-type="pmid">19065586</pub-id></element-citation></ref><ref id="ref108"><label>108</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Walle</surname><given-names>T</given-names></name><name><surname>Ta</surname><given-names>N</given-names></name><name><surname>Kawamori</surname><given-names>T</given-names></name><name><surname>Wen</surname><given-names>X</given-names></name><name><surname>Tsuji</surname><given-names>PA</given-names></name><name><surname>Walle</surname><given-names>UK</given-names></name></person-group><article-title>Cancer chemopreventive properties of orally bioavailable flavonoids-methylated versus unmethylated flavones</article-title><source>Biochem Pharmacol</source><year>2007</year><volume>73</volume><fpage>1288</fpage><lpage>96</lpage><pub-id pub-id-type="pmid">17250812</pub-id></element-citation></ref><ref id="ref109"><label>109</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Seibert</surname><given-names>H</given-names></name><name><surname>Maser</surname><given-names>E</given-names></name><name><surname>Schweda</surname><given-names>K</given-names></name><name><surname>Seibert</surname><given-names>S</given-names></name><name><surname>Gülden</surname><given-names>M</given-names></name></person-group><article-title>Cytoprotective activity against peroxide-induced oxidative damage and cytotoxicity of flavonoids in C6 rat glioma cells</article-title><source>Food Chem Toxicol</source><year>2011</year><volume>49</volume><fpage>2398</fpage><lpage>407</lpage><pub-id pub-id-type="pmid">21723910</pub-id></element-citation></ref><ref id="ref110"><label>110</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Iwuchukwu</surname><given-names>OF</given-names></name><name><surname>Tallarida</surname><given-names>RJ</given-names></name><name><surname>Nagar</surname><given-names>S</given-names></name></person-group><article-title>Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cells</article-title><source>Life Sci</source><year>2011</year><volume>88</volume><fpage>1047</fpage><lpage>54</lpage><pub-id pub-id-type="pmid">21466813</pub-id></element-citation></ref><ref id="ref111"><label>111</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sun</surname><given-names>F</given-names></name><name><surname>Zheng</surname><given-names>XY</given-names></name><name><surname>Ye</surname><given-names>J</given-names></name><name><surname>Wu</surname><given-names>TT</given-names></name><name><surname>Wang</surname><given-names>JI</given-names></name><name><surname>Chen</surname><given-names>W</given-names></name></person-group><article-title>Potential anticancer activity of myricetin in human T24 bladder cancer cells both <italic>in vitro</italic> and <italic>in vivo</italic></article-title><source>Nutr Cancer</source><year>2012</year><volume>64</volume><fpage>599</fpage><lpage>606</lpage><pub-id pub-id-type="pmid">22482362</pub-id></element-citation></ref><ref id="ref112"><label>112</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rodgers</surname><given-names>EH</given-names></name><name><surname>Grant</surname><given-names>MH</given-names></name></person-group><article-title>The effect of the flavonoids, quercetin, myricetin and epicatechin on the growth and enzyme activities of MCF7 human breast cancer cells</article-title><source>Chem Biol Interact</source><year>1998</year><volume>116</volume><fpage>213</fpage><lpage>28</lpage><pub-id pub-id-type="pmid">9920463</pub-id></element-citation></ref><ref id="ref113"><label>113</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Forni</surname><given-names>C</given-names></name><name><surname>Braglia</surname><given-names>R</given-names></name><name><surname>Lentini</surname><given-names>A</given-names></name><name><surname>Nuccetelli</surname><given-names>M</given-names></name><name><surname>Provenzano</surname><given-names>B</given-names></name><name><surname>Tabolacci</surname><given-names>C</given-names></name><etal></etal></person-group><article-title>Role of transglutaminase 2 in quercetin-induced differentiation of B16-F10 murine melanoma cells</article-title><source>Amino Acids</source><year>2009</year><volume>36</volume><fpage>731</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">18688565</pub-id></element-citation></ref><ref id="ref114"><label>114</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nagao</surname><given-names>T</given-names></name><name><surname>Abe</surname><given-names>F</given-names></name><name><surname>Kinjo</surname><given-names>J</given-names></name><name><surname>Okabe</surname><given-names>H</given-names></name></person-group><article-title>Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship</article-title><source>Biol Pharm Bull</source><year>2002</year><volume>25</volume><fpage>875</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">12132661</pub-id></element-citation></ref><ref id="ref115"><label>115</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Himeji</surname><given-names>M</given-names></name><name><surname>Ohtsuki</surname><given-names>T</given-names></name><name><surname>Fukazawa</surname><given-names>H</given-names></name><name><surname>Tanaka</surname><given-names>M</given-names></name><name><surname>Yazaki</surname><given-names>S</given-names></name><name><surname>Ui</surname><given-names>S</given-names></name><etal></etal></person-group><article-title>Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell</article-title><source>Cancer Lett</source><year>2007</year><volume>245</volume><fpage>269</fpage><lpage>74</lpage><pub-id pub-id-type="pmid">16497434</pub-id></element-citation></ref><ref id="ref116"><label>116</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ikezoe</surname><given-names>T</given-names></name><name><surname>Chen</surname><given-names>SS</given-names></name><name><surname>Heber</surname><given-names>D</given-names></name><name><surname>Taguchi</surname><given-names>H</given-names></name><name><surname>Koeffler</surname><given-names>HP</given-names></name></person-group><article-title>Baicalin is a major component of PC-SPES which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrest</article-title><source>Prostate</source><year>2001</year><volume>49</volume><fpage>285</fpage><lpage>92</lpage><pub-id pub-id-type="pmid">11746275</pub-id></element-citation></ref><ref id="ref117"><label>117</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bonham</surname><given-names>M</given-names></name><name><surname>Posakony</surname><given-names>J</given-names></name><name><surname>Coleman</surname><given-names>I</given-names></name><name><surname>Montgomery</surname><given-names>B</given-names></name><name><surname>Simon</surname><given-names>J</given-names></name><name><surname>Nelson</surname><given-names>PS</given-names></name><etal></etal></person-group><article-title>Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma</article-title><source>Clin Cancer Res</source><year>2005</year><volume>11</volume><fpage>3905</fpage><lpage>14</lpage><pub-id pub-id-type="pmid">15897592</pub-id></element-citation></ref><ref id="ref118"><label>118</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zheng</surname><given-names>Q</given-names></name><name><surname>Hirose</surname><given-names>Y</given-names></name><name><surname>Yoshimi</surname><given-names>N</given-names></name><name><surname>Murakami</surname><given-names>A</given-names></name><name><surname>Koshimizu</surname><given-names>K</given-names></name><name><surname>Ohigashi</surname><given-names>H</given-names></name><etal></etal></person-group><article-title>Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells</article-title><source>J Cancer Res Clin Oncol</source><year>2002</year><volume>128</volume><fpage>539</fpage><lpage>46</lpage><pub-id pub-id-type="pmid">12384797</pub-id></element-citation></ref><ref id="ref119"><label>119</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chen</surname><given-names>CH</given-names></name><name><surname>Huang</surname><given-names>LL</given-names></name><name><surname>Huang</surname><given-names>CC</given-names></name><name><surname>Lin</surname><given-names>CC</given-names></name><name><surname>Lee</surname><given-names>Y</given-names></name><name><surname>Lu</surname><given-names>FJ</given-names></name></person-group><article-title>Baicalein, a novel apoptotic agent for hepatoma cell lines: A potential medicine for hepatoma</article-title><source>Nutr Cancer</source><year>2000</year><volume>38</volume><fpage>287</fpage><lpage>95</lpage><pub-id pub-id-type="pmid">11525608</pub-id></element-citation></ref><ref id="ref120"><label>120</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kuo</surname><given-names>SM</given-names></name></person-group><article-title>Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells</article-title><source>Cancer Lett</source><year>1996</year><volume>110</volume><fpage>41</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">9018079</pub-id></element-citation></ref><ref id="ref121"><label>121</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hong</surname><given-names>TB</given-names></name><name><surname>Rahumatullah</surname><given-names>A</given-names></name><name><surname>Yogarajah</surname><given-names>T</given-names></name><name><surname>Ahmad</surname><given-names>M</given-names></name><name><surname>Yin</surname><given-names>KB</given-names></name></person-group><article-title>Potential effects of chrysin on MDA-MB-231 cells</article-title><source>Int J Mol Sci</source><year>2010</year><volume>11</volume><fpage>1057</fpage><lpage>69</lpage><pub-id pub-id-type="pmid">20479999</pub-id></element-citation></ref><ref id="ref122"><label>122</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yang</surname><given-names>SF</given-names></name><name><surname>Yang</surname><given-names>WE</given-names></name><name><surname>Chang</surname><given-names>HR</given-names></name><name><surname>Chu</surname><given-names>SC</given-names></name><name><surname>Hsieh</surname><given-names>YS</given-names></name></person-group><article-title>Luteolin induces apoptosis in oral squamous cancer cells</article-title><source>J Dent Res</source><year>2008</year><volume>87</volume><fpage>401</fpage><lpage>6</lpage><pub-id pub-id-type="pmid">18362328</pub-id></element-citation></ref><ref id="ref123"><label>123</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wu</surname><given-names>B</given-names></name><name><surname>Zhang</surname><given-names>Q</given-names></name><name><surname>Shen</surname><given-names>W</given-names></name><name><surname>Zhu</surname><given-names>J</given-names></name></person-group><article-title>Anti-proliferative and chemosensitizing effects of luteolin on human gastric cancer AGS cell line</article-title><source>Mol Cell Biochem</source><year>2008</year><volume>313</volume><fpage>125</fpage><lpage>32</lpage><pub-id pub-id-type="pmid">18398671</pub-id></element-citation></ref><ref id="ref124"><label>124</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Patil</surname><given-names>JR</given-names></name><name><surname>Chidambara</surname><given-names>Murthy KN</given-names></name><name><surname>Jayaprakasha</surname><given-names>GK</given-names></name><name><surname>Chetti</surname><given-names>MB</given-names></name><name><surname>Patil</surname><given-names>BS</given-names></name></person-group><article-title>Bioactive compounds from Mexican lime (Citrus aurantifolia) juice induce apoptosis in human pancreatic cells</article-title><source>J Agric Food Chem</source><year>2009</year><volume>57</volume><fpage>10933</fpage><lpage>42</lpage><pub-id pub-id-type="pmid">19919125</pub-id></element-citation></ref><ref id="ref125"><label>125</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>W</given-names></name><name><surname>Du</surname><given-names>B</given-names></name><name><surname>Wang</surname><given-names>T</given-names></name><name><surname>Wang</surname><given-names>S</given-names></name><name><surname>Zhang</surname><given-names>J</given-names></name></person-group><article-title>Kaempferol induces apoptosis in human HCT116 colon cancer cells via the Ataxia-Telangiectasia Mutated-p53 pathway with the involvement of p53 Upregulated Modulator of Apoptosis</article-title><source>Chem Biol Interact</source><year>2009</year><volume>177</volume><fpage>121</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">19028473</pub-id></element-citation></ref><ref id="ref126"><label>126</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Luo</surname><given-names>H</given-names></name><name><surname>Rankin</surname><given-names>GO</given-names></name><name><surname>Li</surname><given-names>Z</given-names></name><name><surname>Depriest</surname><given-names>L</given-names></name><name><surname>Chen</surname><given-names>YC</given-names></name></person-group><article-title>Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway</article-title><source>Food Chem</source><year>2011</year><volume>128</volume><fpage>513</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">21625365</pub-id></element-citation></ref><ref id="ref127"><label>127</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>W</given-names></name><name><surname>Heideman</surname><given-names>L</given-names></name><name><surname>Chung</surname><given-names>CS</given-names></name><name><surname>Pelling</surname><given-names>JC</given-names></name><name><surname>Koehler</surname><given-names>KJ</given-names></name><name><surname>Birt</surname><given-names>DF</given-names></name></person-group><article-title>Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines</article-title><source>Mol Carcinog</source><year>2000</year><volume>28</volume><fpage>102</fpage><lpage>10</lpage><pub-id pub-id-type="pmid">10900467</pub-id></element-citation></ref><ref id="ref128"><label>128</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sivagami</surname><given-names>G</given-names></name><name><surname>Vinothkumar</surname><given-names>R</given-names></name><name><surname>Preethy</surname><given-names>CP</given-names></name><name><surname>Riyasdeen</surname><given-names>A</given-names></name><name><surname>Akbarsha</surname><given-names>MA</given-names></name><name><surname>Menon</surname><given-names>VP</given-names></name><etal></etal></person-group><article-title>Role of hesperetin (a natural flavonoid) and its analogue on apoptosis in HT-29 human colon adenocarcinoma cell line: A comparative study</article-title><source>Food Chem Toxicol</source><year>2012</year><volume>50</volume><fpage>660</fpage><lpage>71</lpage><pub-id pub-id-type="pmid">22142698</pub-id></element-citation></ref><ref id="ref129"><label>129</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>You</surname><given-names>HJ</given-names></name><name><surname>Ahn</surname><given-names>HJ</given-names></name><name><surname>Ji</surname><given-names>GE</given-names></name></person-group><article-title>Transformation of rutin to antiproliferative quercetin-3-glucoside by Aspergillus niger</article-title><source>J Agric Food Chem</source><year>2010</year><volume>58</volume><fpage>10886</fpage><lpage>92</lpage><pub-id pub-id-type="pmid">20886886</pub-id></element-citation></ref><ref id="ref130"><label>130</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cai</surname><given-names>J</given-names></name><name><surname>Zhao</surname><given-names>XL</given-names></name><name><surname>Liu</surname><given-names>AW</given-names></name><name><surname>Nian</surname><given-names>H</given-names></name><name><surname>Zhang</surname><given-names>SH</given-names></name></person-group><article-title>Apigenin inhibits hepatoma cell growth through alteration of gene expression patterns</article-title><source>Phytomedicine</source><year>2011</year><volume>18</volume><fpage>366</fpage><lpage>73</lpage><pub-id pub-id-type="pmid">20850954</pub-id></element-citation></ref><ref id="ref131"><label>131</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wei</surname><given-names>L</given-names></name><name><surname>Lu</surname><given-names>N</given-names></name><name><surname>Dai</surname><given-names>Q</given-names></name><name><surname>Rong</surname><given-names>J</given-names></name><name><surname>Chen</surname><given-names>Y</given-names></name><name><surname>Li</surname><given-names>Z</given-names></name><etal></etal></person-group><article-title>Different apoptotic effects of wogonin via induction of H(2)O(2) generation and Ca(2+) overload in malignant hepatoma and normal hepatic cells</article-title><source>J Cell Biochem</source><year>2010</year><volume>111</volume><fpage>1629</fpage><lpage>41</lpage><pub-id pub-id-type="pmid">21053277</pub-id></element-citation></ref><ref id="ref132"><label>132</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Xu</surname><given-names>M</given-names></name><name><surname>Lu</surname><given-names>N</given-names></name><name><surname>Zhang</surname><given-names>H</given-names></name><name><surname>Dai</surname><given-names>Q</given-names></name><name><surname>Wei</surname><given-names>L</given-names></name><name><surname>Li</surname><given-names>Z</given-names></name><etal></etal></person-group><article-title>Wogonin induced cytotoxicity in human hepatocellular carcinoma cells by activation of unfolded protein response and inactivation of AKT</article-title><source>Hepatol Res</source><year>2013</year><volume>43</volume><fpage>890</fpage><lpage>905</lpage><pub-id pub-id-type="pmid">23294370</pub-id></element-citation></ref><ref id="ref133"><label>133</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Romanouskaya</surname><given-names>TV</given-names></name><name><surname>Grinev</surname><given-names>VV</given-names></name></person-group><article-title>Cytotoxic effect of flavonoids on leukemia cells and normal cells of human blood</article-title><source>Bull Exp Biol Med</source><year>2009</year><volume>148</volume><fpage>57</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">19902097</pub-id></element-citation></ref><ref id="ref134"><label>134</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jang</surname><given-names>KY</given-names></name><name><surname>Jeong</surname><given-names>SJ</given-names></name><name><surname>Kim</surname><given-names>SH</given-names></name><name><surname>Jung</surname><given-names>JH</given-names></name><name><surname>Kim</surname><given-names>JH</given-names></name><name><surname>Koh</surname><given-names>W</given-names></name><etal></etal></person-group><article-title>Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells</article-title><source>Cancer Lett</source><year>2012</year><volume>319</volume><fpage>197</fpage><lpage>202</lpage><pub-id pub-id-type="pmid">22261340</pub-id></element-citation></ref><ref id="ref135"><label>135</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baumann</surname><given-names>S</given-names></name><name><surname>Fas</surname><given-names>SC</given-names></name><name><surname>Giaisi</surname><given-names>M</given-names></name><name><surname>Müller</surname><given-names>WW</given-names></name><name><surname>Merling</surname><given-names>A</given-names></name><name><surname>Gülow</surname><given-names>K</given-names></name><etal></etal></person-group><article-title>Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca<sup>2+</sup>-dependent apoptosis</article-title><source>Blood</source><year>2008</year><volume>111</volume><fpage>2354</fpage><lpage>63</lpage><pub-id pub-id-type="pmid">18070986</pub-id></element-citation></ref><ref id="ref136"><label>136</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Guthrie</surname><given-names>N</given-names></name><name><surname>Gapor</surname><given-names>A</given-names></name><name><surname>Chambers</surname><given-names>AF</given-names></name><name><surname>Carroll</surname><given-names>KK</given-names></name></person-group><article-title>Palm oil tocotrienols and plant flavonoids act synergistically to inhibit proliferation of estrogen receptor-negative MDA-MB-231 and -positive MCF-7 human breast cancer cells in culture</article-title><source>Asia Pacific J Clin Nutr</source><year>1997</year><volume>6</volume><fpage>41</fpage><lpage>5</lpage></element-citation></ref><ref id="ref137"><label>137</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>LM</given-names></name><name><surname>Xie</surname><given-names>KP</given-names></name><name><surname>Huo</surname><given-names>HN</given-names></name><name><surname>Shang</surname><given-names>F</given-names></name><name><surname>Zou</surname><given-names>W</given-names></name><name><surname>Xie</surname><given-names>MJ</given-names></name></person-group><article-title>Luteolin inhibits proliferation induced by IGF-1 pathway dependent ERα in human breast cancer MCF-7 cells</article-title><source>Asian Pac J Cancer Prev</source><year>2012</year><volume>13</volume><fpage>1431</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">22799344</pub-id></element-citation></ref><ref id="ref138"><label>138</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kim</surname><given-names>MJ</given-names></name><name><surname>Woo</surname><given-names>JS</given-names></name><name><surname>Kwon</surname><given-names>CH</given-names></name><name><surname>Kim</surname><given-names>JH</given-names></name><name><surname>Kim</surname><given-names>YK</given-names></name><name><surname>Kim</surname><given-names>KH</given-names></name></person-group><article-title>Luteolin induces apoptotic cell death through AIF nuclear translocation mediated by activation of ERK and p38 in human breast cancer cell lines</article-title><source>Cell Biol Int</source><year>2012</year><volume>36</volume><fpage>339</fpage><lpage>44</lpage><pub-id pub-id-type="pmid">22073986</pub-id></element-citation></ref><ref id="ref139"><label>139</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Long</surname><given-names>X</given-names></name><name><surname>Fan</surname><given-names>M</given-names></name><name><surname>Bigsby</surname><given-names>RM</given-names></name><name><surname>Nephew</surname><given-names>KP</given-names></name></person-group><article-title>Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-alpha-dependent and estrogen receptor-alpha-independent mechanisms</article-title><source>Mol Cancer Ther</source><year>2008</year><volume>7</volume><fpage>2096</fpage><lpage>108</lpage><pub-id pub-id-type="pmid">18645020</pub-id></element-citation></ref><ref id="ref140"><label>140</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Britton</surname><given-names>RG</given-names></name><name><surname>Horner-Glister</surname><given-names>E</given-names></name><name><surname>Pomenya</surname><given-names>OA</given-names></name><name><surname>Smith</surname><given-names>EE</given-names></name><name><surname>Denton</surname><given-names>R</given-names></name><name><surname>Jenkins</surname><given-names>PR</given-names></name><etal></etal></person-group><article-title>Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents</article-title><source>Eur J Med Chem</source><year>2012</year><volume>54</volume><fpage>952</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">22789812</pub-id></element-citation></ref><ref id="ref141"><label>141</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kim</surname><given-names>JY</given-names></name><name><surname>Jeon</surname><given-names>YK</given-names></name><name><surname>Jeon</surname><given-names>W</given-names></name><name><surname>Nam</surname><given-names>MJ</given-names></name></person-group><article-title>Fisetin induces apoptosis in Huh-7 cells via downregulation of BIRC8 and Bcl2L2</article-title><source>Food Chem Toxicol</source><year>2010</year><volume>48</volume><fpage>2259</fpage><lpage>64</lpage><pub-id pub-id-type="pmid">20510331</pub-id></element-citation></ref><ref id="ref142"><label>142</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Khan</surname><given-names>N</given-names></name><name><surname>Asim</surname><given-names>M</given-names></name><name><surname>Afaq</surname><given-names>F</given-names></name><name><surname>Abu Zaid</surname><given-names>M</given-names></name><name><surname>Mukhtar</surname><given-names>H</given-names></name></person-group><article-title>A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice</article-title><source>Cancer Res</source><year>2008</year><volume>68</volume><fpage>8555</fpage><lpage>63</lpage><pub-id pub-id-type="pmid">18922931</pub-id></element-citation></ref><ref id="ref143"><label>143</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Seo</surname><given-names>YJ</given-names></name><name><surname>Kim</surname><given-names>BS</given-names></name><name><surname>Chun</surname><given-names>SY</given-names></name><name><surname>Park</surname><given-names>YK</given-names></name><name><surname>Kang</surname><given-names>KS</given-names></name><name><surname>Kwon</surname><given-names>TG</given-names></name></person-group><article-title>Apoptotic effects of genistein, biochanin-A and apigenin on LNCaP and PC-3 cells by p21 through transcriptional inhibition of polo-like kinase-1</article-title><source>J Korean Med Sci</source><year>2011</year><volume>26</volume><fpage>1489</fpage><lpage>94</lpage><pub-id pub-id-type="pmid">22065906</pub-id></element-citation></ref><ref id="ref144"><label>144</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chen</surname><given-names>S</given-names></name><name><surname>Ruan</surname><given-names>Q</given-names></name><name><surname>Bedner</surname><given-names>E</given-names></name><name><surname>Deptala</surname><given-names>A</given-names></name><name><surname>Wang</surname><given-names>X</given-names></name><name><surname>Hsieh</surname><given-names>TC</given-names></name><etal></etal></person-group><article-title>Effects of the flavonoid baicalin and its metabolite baicalein on androgen receptor expression, cell cycle progression and apoptosis of prostate cancer cell lines</article-title><source>Cell Prolif</source><year>2001</year><volume>34</volume><fpage>293</fpage><lpage>304</lpage><pub-id pub-id-type="pmid">11591177</pub-id></element-citation></ref><ref id="ref145"><label>145</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pan</surname><given-names>MH</given-names></name><name><surname>Chen</surname><given-names>WJ</given-names></name><name><surname>Lin-Shiau</surname><given-names>SY</given-names></name><name><surname>Ho</surname><given-names>CT</given-names></name><name><surname>Lin</surname><given-names>JK</given-names></name></person-group><article-title>Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells</article-title><source>Carcinogenesis</source><year>2002</year><volume>23</volume><fpage>1677</fpage><lpage>84</lpage><pub-id pub-id-type="pmid">12376477</pub-id></element-citation></ref><ref id="ref146"><label>146</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yang</surname><given-names>J</given-names></name><name><surname>Liu</surname><given-names>RH</given-names></name></person-group><article-title>Synergistic effect of apple extracts and quercetin 3-beta-d-glucoside combination on antiproliferative activity in MCF-7 human breast cancer cells <italic>in vitro</italic></article-title><source>J Agric Food Chem</source><year>2009</year><volume>57</volume><fpage>8581</fpage><lpage>6</lpage><pub-id pub-id-type="pmid">19694432</pub-id></element-citation></ref><ref id="ref147"><label>147</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Parajuli</surname><given-names>P</given-names></name><name><surname>Joshee</surname><given-names>N</given-names></name><name><surname>Rimando</surname><given-names>AM</given-names></name><name><surname>Mittal</surname><given-names>S</given-names></name><name><surname>Yadav</surname><given-names>AK</given-names></name></person-group><article-title><italic>In vitro</italic> antitumor mechanisms of various Scutellaria extracts and constituent flavonoids</article-title><source>Planta Med</source><year>2009</year><volume>75</volume><fpage>41</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">19031366</pub-id></element-citation></ref><ref id="ref148"><label>148</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Skupień</surname><given-names>K</given-names></name><name><surname>Oszmiański</surname><given-names>J</given-names></name><name><surname>Kostrzewa-Nowak</surname><given-names>D</given-names></name><name><surname>Tarasiuk</surname><given-names>J</given-names></name></person-group><article-title><italic>In vitro</italic> antileukaemic activity of extracts from berry plant leaves against sensitive and multidrug resistant HL60 cells</article-title><source>Cancer Lett</source><year>2006</year><volume>236</volume><fpage>282</fpage><lpage>91</lpage><pub-id pub-id-type="pmid">16039042</pub-id></element-citation></ref><ref id="ref149"><label>149</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lu</surname><given-names>HF</given-names></name><name><surname>Chie</surname><given-names>YJ</given-names></name><name><surname>Yang</surname><given-names>MS</given-names></name><name><surname>Lee</surname><given-names>CS</given-names></name><name><surname>Fu</surname><given-names>JJ</given-names></name><name><surname>Yang</surname><given-names>JS</given-names></name><etal></etal></person-group><article-title>Apigenin induces caspase-dependent apoptosis in human lung cancer A549 cells through Bax- and Bcl-2-triggered mitochondrial pathway</article-title><source>Int J Oncol</source><year>2010</year><volume>36</volume><fpage>1477</fpage><lpage>84</lpage><pub-id pub-id-type="pmid">20428772</pub-id></element-citation></ref><ref id="ref150"><label>150</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chen</surname><given-names>WY</given-names></name><name><surname>Hsieh</surname><given-names>YA</given-names></name><name><surname>Tsai</surname><given-names>CI</given-names></name><name><surname>Kang</surname><given-names>YF</given-names></name><name><surname>Chang</surname><given-names>FR</given-names></name><name><surname>Wu</surname><given-names>YC</given-names></name><etal></etal></person-group><article-title>Protoapigenone, a natural derivative of apigenin, induces mitogen-activated protein kinase-dependent apoptosis in human breast cancer cells associated with induction of oxidative stress and inhibition of glutathione S-transferase TT</article-title><source>Invest New Drugs</source><year>2011</year><volume>29</volume><fpage>1347</fpage><lpage>59</lpage><pub-id pub-id-type="pmid">20686818</pub-id></element-citation></ref><ref id="ref151"><label>151</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Strouch</surname><given-names>MJ</given-names></name><name><surname>Milam</surname><given-names>BM</given-names></name><name><surname>Melstrom</surname><given-names>LG</given-names></name><name><surname>McGill</surname><given-names>JJ</given-names></name><name><surname>Salabat</surname><given-names>MR</given-names></name><name><surname>Ujiki</surname><given-names>MB</given-names></name><etal></etal></person-group><article-title>The flavonoid apigenin potentiates the growth inhibitory effects of gemcitabine and abrogates gemcitabine resistance in human pancreatic cancer cells</article-title><source>Pancreas</source><year>2009</year><volume>38</volume><fpage>409</fpage><lpage>15</lpage><pub-id pub-id-type="pmid">19142175</pub-id></element-citation></ref><ref id="ref152"><label>152</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sak</surname><given-names>K</given-names></name></person-group><article-title>Site-specific anticancer effects of dietay flavonoid quercetin</article-title><source>Nutr Cancer</source><year>2014</year><volume>66</volume><fpage>177</fpage><lpage>93</lpage><pub-id pub-id-type="pmid">24377461</pub-id></element-citation></ref><ref id="ref153"><label>153</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Suh</surname><given-names>Y</given-names></name><name><surname>Afaq</surname><given-names>F</given-names></name><name><surname>Johnson</surname><given-names>JJ</given-names></name><name><surname>Mukhtar</surname><given-names>H</given-names></name></person-group><article-title>A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB signaling pathways</article-title><source>Carcinogenesis</source><year>2009</year><volume>30</volume><fpage>300</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">19037088</pub-id></element-citation></ref><ref id="ref154"><label>154</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Syed</surname><given-names>DN</given-names></name><name><surname>Afaq</surname><given-names>F</given-names></name><name><surname>Maddodi</surname><given-names>N</given-names></name><name><surname>Johnson</surname><given-names>JJ</given-names></name><name><surname>Sarfaraz</surname><given-names>S</given-names></name><name><surname>Ahmad</surname><given-names>A</given-names></name><etal></etal></person-group><article-title>Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/β-catenin signaling and decreased Mitf levels</article-title><source>J Invest Dermatol</source><year>2011</year><volume>131</volume><fpage>1291</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">21346776</pub-id></element-citation></ref><ref id="ref155"><label>155</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lim do</surname><given-names>Y</given-names></name><name><surname>Park</surname><given-names>JH</given-names></name></person-group><article-title>Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the diteary compound fisetin</article-title><source>Am J Physiol Gastrointest Liver Physiol</source><year>2009</year><volume>296</volume><fpage>G1060</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">19264955</pub-id></element-citation></ref><ref id="ref156"><label>156</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Khan</surname><given-names>N</given-names></name><name><surname>Afaq</surname><given-names>F</given-names></name><name><surname>Khusro</surname><given-names>FH</given-names></name><name><surname>Mustafa</surname><given-names>Adhami V</given-names></name><name><surname>Suh</surname><given-names>Y</given-names></name><name><surname>Mukhtar</surname><given-names>H</given-names></name></person-group><article-title>Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietay flavonoid fisetin</article-title><source>Int J Cancer</source><year>2012</year><volume>130</volume><fpage>1695</fpage><lpage>705</lpage><pub-id pub-id-type="pmid">21618507</pub-id></element-citation></ref><ref id="ref157"><label>157</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Khan</surname><given-names>N</given-names></name><name><surname>Afaq</surname><given-names>F</given-names></name><name><surname>Syed</surname><given-names>DN</given-names></name><name><surname>Mukhtar</surname><given-names>H</given-names></name></person-group><article-title>Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells</article-title><source>Carcinogenesis</source><year>2008</year><volume>29</volume><fpage>1049</fpage><lpage>56</lpage><pub-id pub-id-type="pmid">18359761</pub-id></element-citation></ref><ref id="ref158"><label>158</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Haddad</surname><given-names>AQ</given-names></name><name><surname>Fleshner</surname><given-names>N</given-names></name><name><surname>Nelson</surname><given-names>C</given-names></name><name><surname>Saour</surname><given-names>B</given-names></name><name><surname>Musquera</surname><given-names>M</given-names></name><name><surname>Venkateswaran</surname><given-names>V</given-names></name><etal></etal></person-group><article-title>Antiproliferative mechanisms of the flavonoids 2,2’-dihydroxychalcone and fisetin in human prostate cancer cells</article-title><source>Nutr Cancer</source><year>2010</year><volume>62</volume><fpage>668</fpage><lpage>81</lpage><pub-id pub-id-type="pmid">20574928</pub-id></element-citation></ref><ref id="ref159"><label>159</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhang</surname><given-names>W</given-names></name><name><surname>Lan</surname><given-names>Y</given-names></name><name><surname>Huang</surname><given-names>Q</given-names></name><name><surname>Hua</surname><given-names>Z</given-names></name></person-group><article-title>Galangin induces B16F10 melanoma cell apoptosis via mitochondrial pathway and sustained activation of p38 MAPK</article-title><source>Cytotechnology</source><year>2013</year><volume>65</volume><fpage>447</fpage><lpage>55</lpage><pub-id pub-id-type="pmid">23001390</pub-id></element-citation></ref><ref id="ref160"><label>160</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Murray</surname><given-names>TJ</given-names></name><name><surname>Yang</surname><given-names>X</given-names></name><name><surname>Sherr</surname><given-names>DH</given-names></name></person-group><article-title>Growth of a human mammary tumor cell line is blocked by galangin, a naturally occurring bioflavonoid, and is accompanied by down-regulation of cyclins D3, E, and A</article-title><source>Breast Cancer Res</source><year>2006</year><volume>8</volume><fpage>R17</fpage><pub-id pub-id-type="pmid">16569260</pub-id></element-citation></ref><ref id="ref161"><label>161</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hernandez</surname><given-names>J</given-names></name><name><surname>Goycoolea</surname><given-names>FM</given-names></name><name><surname>Quintero</surname><given-names>J</given-names></name><name><surname>Acosta</surname><given-names>A</given-names></name><name><surname>Castaneda</surname><given-names>M</given-names></name><name><surname>Dominguez</surname><given-names>Z</given-names></name><etal></etal></person-group><article-title>Sonoran propolis: Chemical composition and antiproliferative activity on cancer cell lines</article-title><source>Planta Med</source><year>2007</year><volume>73</volume><fpage>1469</fpage><lpage>74</lpage><pub-id pub-id-type="pmid">17948188</pub-id></element-citation></ref><ref id="ref162"><label>162</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bestwick</surname><given-names>CS</given-names></name><name><surname>Milne</surname><given-names>L</given-names></name><name><surname>Duthie</surname><given-names>SJ</given-names></name></person-group><article-title>Kaempferol induced inhibition of HL-60 cell growth results from a heterogeneous response, dominated by cell cycle alterations</article-title><source>Chem Biol Interact</source><year>2007</year><volume>170</volume><fpage>76</fpage><lpage>85</lpage><pub-id pub-id-type="pmid">17765212</pub-id></element-citation></ref><ref id="ref163"><label>163</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ackland</surname><given-names>ML</given-names></name><name><surname>van de Waarsenburg</surname><given-names>S</given-names></name><name><surname>Jones</surname><given-names>R</given-names></name></person-group><article-title>Synergistic antiproliferative action of the flavonols quercetin and kaempferol in cultured human cancer cell lines</article-title><source>In Vivo</source><year>2005</year><volume>19</volume><fpage>69</fpage><lpage>76</lpage><pub-id pub-id-type="pmid">15796157</pub-id></element-citation></ref><ref id="ref164"><label>164</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fabjan</surname><given-names>N</given-names></name><name><surname>Rode</surname><given-names>J</given-names></name><name><surname>Kosir</surname><given-names>IJ</given-names></name><name><surname>Wang</surname><given-names>Z</given-names></name><name><surname>Zhang</surname><given-names>Z</given-names></name><name><surname>Kreft</surname><given-names>I</given-names></name></person-group><article-title>Tartary buckwheat (Fagopyrum tataricum Gaertn.) as a course of dietary rutin and quercitrin</article-title><source>J Agric Food Chem</source><year>2003</year><volume>51</volume><fpage>6452</fpage><lpage>5</lpage><pub-id pub-id-type="pmid">14558761</pub-id></element-citation></ref><ref id="ref165"><label>165</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mämmelä</surname><given-names>P</given-names></name><name><surname>Savolainen</surname><given-names>H</given-names></name><name><surname>Lindroos</surname><given-names>L</given-names></name><name><surname>Kangas</surname><given-names>J</given-names></name><name><surname>Vartiainen</surname><given-names>T</given-names></name></person-group><article-title>Analysis of oak tannins by liquid chromatography-electrospray ionisation mass spectrometry</article-title><source>J Chromatogr A</source><year>2000</year><volume>891</volume><fpage>75</fpage><lpage>83</lpage><pub-id pub-id-type="pmid">10999626</pub-id></element-citation></ref><ref id="ref166"><label>166</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jiang</surname><given-names>S</given-names></name><name><surname>Yang</surname><given-names>J</given-names></name><name><surname>Qian</surname><given-names>D</given-names></name><name><surname>Guo</surname><given-names>J</given-names></name><name><surname>Shang</surname><given-names>EX</given-names></name><name><surname>Duan</surname><given-names>JA</given-names></name><etal></etal></person-group><article-title>Rapid screening and identification of metabolites of quercitrin produced by the human intestinal bacteria using ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry</article-title><source>Arch Pharm Res</source><year>2014</year><volume>37</volume><fpage>204</fpage><lpage>13</lpage><pub-id pub-id-type="pmid">23754166</pub-id></element-citation></ref><ref id="ref167"><label>167</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Thani</surname><given-names>W</given-names></name><name><surname>Vallisuta</surname><given-names>O</given-names></name><name><surname>Siripong</surname><given-names>P</given-names></name><name><surname>Ruangwises</surname><given-names>N</given-names></name></person-group><article-title>Anti-proliferative and antioxidative activities of Thai noni/Yor (Morinda citrifolia Linn.) leaf extract</article-title><source>Southeast Asian J Trop Med Public Health</source><year>2010</year><volume>41</volume><fpage>482</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">20578533</pub-id></element-citation></ref><ref id="ref168"><label>168</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>ER</given-names></name><name><surname>Kang</surname><given-names>YJ</given-names></name><name><surname>Kim</surname><given-names>HJ</given-names></name><name><surname>Choi</surname><given-names>HY</given-names></name><name><surname>Kang</surname><given-names>GH</given-names></name><name><surname>Kim</surname><given-names>JH</given-names></name><etal></etal></person-group><article-title>Regulation of apoptosis by modified naringenin derivatives in human colorectal carcinoma RKO cells</article-title><source>J Cell Biochem</source><year>2008</year><volume>104</volume><fpage>259</fpage><lpage>73</lpage><pub-id pub-id-type="pmid">18004724</pub-id></element-citation></ref><ref id="ref169"><label>169</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Frydoonfar</surname><given-names>HR</given-names></name><name><surname>McGrath</surname><given-names>DR</given-names></name><name><surname>Spigelman</surname><given-names>AD</given-names></name></person-group><article-title>The variable effect on proliferation of a colon cancer cell line by the citrus fruit flavonoid Naringenin</article-title><source>Colorectal Dis</source><year>2003</year><volume>5</volume><fpage>149</fpage><lpage>52</lpage><pub-id pub-id-type="pmid">12780904</pub-id></element-citation></ref><ref id="ref170"><label>170</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Alshatwi</surname><given-names>AA</given-names></name><name><surname>Hasan</surname><given-names>TN</given-names></name><name><surname>Shafi</surname><given-names>G</given-names></name><name><surname>Alsaif</surname><given-names>MA</given-names></name><name><surname>Al-Hazzani</surname><given-names>AA</given-names></name><name><surname>Alsaif</surname><given-names>AA</given-names></name></person-group><article-title>A single-nucleotide polymorphism in the TP53 and MDM-2 gene modifies breast cancer risk in an ethnic Arab population</article-title><source>Fundam Clin Pharmacol</source><year>2012</year><volume>26</volume><fpage>438</fpage><lpage>43</lpage><pub-id pub-id-type="pmid">21477265</pub-id></element-citation></ref><ref id="ref171"><label>171</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zarebczan</surname><given-names>B</given-names></name><name><surname>Pinchot</surname><given-names>SN</given-names></name><name><surname>Kunnimalaiyaan</surname><given-names>M</given-names></name><name><surname>Chen</surname><given-names>H</given-names></name></person-group><article-title>Hesperetin, a potential therapy for carcinoid cancer</article-title><source>Am J Surg</source><year>2011</year><volume>201</volume><fpage>329</fpage><lpage>32</lpage><pub-id pub-id-type="pmid">21367373</pub-id></element-citation></ref><ref id="ref172"><label>172</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Quintin</surname><given-names>J</given-names></name><name><surname>Buisson</surname><given-names>D</given-names></name><name><surname>Thoret</surname><given-names>S</given-names></name><name><surname>Cresteil</surname><given-names>T</given-names></name><name><surname>Lewin</surname><given-names>G</given-names></name></person-group><article-title>Semisynthesis and antiproliferative evaluation of a series of 3’-aminoflavones</article-title><source>Bioorg Med Chem Lett</source><year>2009</year><volume>19</volume><fpage>3502</fpage><lpage>6</lpage><pub-id pub-id-type="pmid">19457664</pub-id></element-citation></ref><ref id="ref173"><label>173</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pereira</surname><given-names>RM</given-names></name><name><surname>Andrades</surname><given-names>NE</given-names></name><name><surname>Paulino</surname><given-names>N</given-names></name><name><surname>Sawaya</surname><given-names>AC</given-names></name><name><surname>Eberlin</surname><given-names>MN</given-names></name><name><surname>Marcucci</surname><given-names>MC</given-names></name><etal></etal></person-group><article-title>Synthesis and characterization of a metal complex containing naringin and Cu, and its antioxidant, antimicrobial, antiinflammatory and tumor cell cytotoxicity</article-title><source>Molecules</source><year>2007</year><volume>12</volume><fpage>1352</fpage><lpage>66</lpage><pub-id pub-id-type="pmid">17909491</pub-id></element-citation></ref><ref id="ref174"><label>174</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zandi</surname><given-names>K</given-names></name><name><surname>Teoh</surname><given-names>BT</given-names></name><name><surname>Sam</surname><given-names>SS</given-names></name><name><surname>Wong</surname><given-names>PF</given-names></name><name><surname>Mustafa</surname><given-names>MR</given-names></name><name><surname>Abubakar</surname><given-names>S</given-names></name></person-group><article-title>Antiviral activity of four types of bioflavonoid against dengue virus type-2</article-title><source>Virol J</source><year>2011</year><volume>8</volume><fpage>560</fpage><pub-id pub-id-type="pmid">22201648</pub-id></element-citation></ref><ref id="ref175"><label>175</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wesolowska</surname><given-names>O</given-names></name><name><surname>Wisniewski</surname><given-names>J</given-names></name><name><surname>Sroda-Pomianek</surname><given-names>K</given-names></name><name><surname>Bielawska-Pohl</surname><given-names>A</given-names></name><name><surname>Paprocka</surname><given-names>M</given-names></name><name><surname>Duś</surname><given-names>D</given-names></name><etal></etal></person-group><article-title>Multidrug resistance reversal and apoptosis induction in human colon cancer cells by some flavonoids present in Citrus plants</article-title><source>J Nat Prod</source><year>2012</year><volume>75</volume><fpage>1896</fpage><lpage>902</lpage><pub-id pub-id-type="pmid">23137376</pub-id></element-citation></ref><ref id="ref176"><label>176</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nazari</surname><given-names>M</given-names></name><name><surname>Ghorbani</surname><given-names>A</given-names></name><name><surname>Hekmat-Doost</surname><given-names>A</given-names></name><name><surname>Jeddi-Tehrani</surname><given-names>M</given-names></name><name><surname>Zand</surname><given-names>H</given-names></name></person-group><article-title>Inactivation of nuclear factor-kB by citrus flavanone hesperidin contributes to apoptosis and chemo-sensitizing effect in Ramos cells</article-title><source>Eur J Pharmacol</source><year>2011</year><volume>650</volume><fpage>526</fpage><lpage>33</lpage><pub-id pub-id-type="pmid">21044621</pub-id></element-citation></ref><ref id="ref177"><label>177</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Al-Ashaal</surname><given-names>HA</given-names></name><name><surname>El-Sheltawy</surname><given-names>ST</given-names></name></person-group><article-title>Antioxidant capacity of hesperidin from citrus peel using electron spin resonance and cytotoxic activity against human carcinoma cell lines</article-title><source>Pharm Biol</source><year>2011</year><volume>49</volume><fpage>276</fpage><lpage>82</lpage><pub-id pub-id-type="pmid">21323480</pub-id></element-citation></ref><ref id="ref178"><label>178</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>WJ</given-names></name><name><surname>Chen</surname><given-names>WK</given-names></name><name><surname>Wang</surname><given-names>CJ</given-names></name><name><surname>Lin</surname><given-names>WL</given-names></name><name><surname>Tseng</surname><given-names>TH</given-names></name></person-group><article-title>Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells</article-title><source>Toxicol Appl Pharmacol</source><year>2008</year><volume>226</volume><fpage>178</fpage><lpage>91</lpage><pub-id pub-id-type="pmid">17961621</pub-id></element-citation></ref><ref id="ref179"><label>179</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gupta</surname><given-names>S</given-names></name><name><surname>Afaq</surname><given-names>F</given-names></name><name><surname>Mukhtar</surname><given-names>H</given-names></name></person-group><article-title>Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells</article-title><source>Oncogene</source><year>2002</year><volume>21</volume><fpage>3727</fpage><lpage>38</lpage><pub-id pub-id-type="pmid">12032841</pub-id></element-citation></ref><ref id="ref180"><label>180</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Choi</surname><given-names>SI</given-names></name><name><surname>Jeong</surname><given-names>CS</given-names></name><name><surname>Cho</surname><given-names>SY</given-names></name><name><surname>Lee</surname><given-names>YS</given-names></name></person-group><article-title>Mechanism of apoptosis induced by apigenin in HepG2 human hepatoma cells: Involvement of reactive oxygen species generated by NADPH oxidase</article-title><source>Arch Pharm Res</source><year>2007</year><volume>30</volume><fpage>1328</fpage><lpage>35</lpage><pub-id pub-id-type="pmid">18038912</pub-id></element-citation></ref><ref id="ref181"><label>181</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mak</surname><given-names>P</given-names></name><name><surname>Leung</surname><given-names>YK</given-names></name><name><surname>Tang</surname><given-names>WY</given-names></name><name><surname>Harwood</surname><given-names>C</given-names></name><name><surname>Ho</surname><given-names>SM</given-names></name></person-group><article-title>Apigenin suppresses cancer cell growth through ERbeta</article-title><source>Neoplasia</source><year>2006</year><volume>8</volume><fpage>896</fpage><lpage>904</lpage><pub-id pub-id-type="pmid">17132221</pub-id></element-citation></ref><ref id="ref182"><label>182</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lu</surname><given-names>HF</given-names></name><name><surname>Chie</surname><given-names>YJ</given-names></name><name><surname>Yang</surname><given-names>MS</given-names></name><name><surname>Lu</surname><given-names>KW</given-names></name><name><surname>Fu</surname><given-names>JJ</given-names></name><name><surname>Yang</surname><given-names>JS</given-names></name><etal></etal></person-group><article-title>Apigenin induces apoptosis in human lung cancer H460 cells through caspase- and mitochondria-dependent pathways</article-title><source>Hum Exp Toxicol</source><year>2011</year><volume>30</volume><fpage>1053</fpage><lpage>61</lpage><pub-id pub-id-type="pmid">20937639</pub-id></element-citation></ref><ref id="ref183"><label>183</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wu</surname><given-names>B</given-names></name><name><surname>Li</surname><given-names>J</given-names></name><name><surname>Huang</surname><given-names>D</given-names></name><name><surname>Wang</surname><given-names>W</given-names></name><name><surname>Chen</surname><given-names>Y</given-names></name><name><surname>Liao</surname><given-names>Y</given-names></name><etal></etal></person-group><article-title>Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells</article-title><source>BMC Cancer</source><year>2011</year><volume>11</volume><fpage>527</fpage><pub-id pub-id-type="pmid">22204275</pub-id></element-citation></ref><ref id="ref184"><label>184</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhang</surname><given-names>DY</given-names></name><name><surname>Wu</surname><given-names>J</given-names></name><name><surname>Ye</surname><given-names>F</given-names></name><name><surname>Xue</surname><given-names>L</given-names></name><name><surname>Jiang</surname><given-names>S</given-names></name><name><surname>Yi</surname><given-names>J</given-names></name><etal></etal></person-group><article-title>Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis</article-title><source>Cancer Res</source><year>2003</year><volume>63</volume><fpage>4037</fpage><lpage>43</lpage><pub-id pub-id-type="pmid">12874003</pub-id></element-citation></ref><ref id="ref185"><label>185</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>QB</given-names></name><name><surname>You</surname><given-names>Y</given-names></name><name><surname>Chen</surname><given-names>ZC</given-names></name><name><surname>Lü</surname><given-names>J</given-names></name><name><surname>Shao</surname><given-names>J</given-names></name><name><surname>Zou</surname><given-names>P</given-names></name></person-group><article-title>Role of Baicalein in the regulation of proliferation and apoptosis in human myeloma RPMI8226 cells</article-title><source>Chin Med J (Engl)</source><year>2006</year><volume>119</volume><fpage>948</fpage><lpage>52</lpage><pub-id pub-id-type="pmid">16780776</pub-id></element-citation></ref><ref id="ref186"><label>186</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chou</surname><given-names>DS</given-names></name><name><surname>Hsiao</surname><given-names>G</given-names></name><name><surname>Lai</surname><given-names>YA</given-names></name><name><surname>Tsai</surname><given-names>YJ</given-names></name><name><surname>Sheu</surname><given-names>JR</given-names></name></person-group><article-title>Baicalein induces proliferation inhibition in B16F10 melanoma cells by generating reactive oxygen species via 12-lipoxygenase</article-title><source>Free Radic Biol Med</source><year>2009</year><volume>46</volume><fpage>1197</fpage><lpage>203</lpage><pub-id pub-id-type="pmid">19439216</pub-id></element-citation></ref><ref id="ref187"><label>187</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Weng</surname><given-names>MS</given-names></name><name><surname>Ho</surname><given-names>YS</given-names></name><name><surname>Lin</surname><given-names>JK</given-names></name></person-group><article-title>Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: Involvement of p38 mitogen-activated protein kinase</article-title><source>Biochem Pharmacol</source><year>2005</year><volume>69</volume><fpage>1815</fpage><lpage>27</lpage><pub-id pub-id-type="pmid">15869744</pub-id></element-citation></ref><ref id="ref188"><label>188</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pichichero</surname><given-names>E</given-names></name><name><surname>Cicconi</surname><given-names>R</given-names></name><name><surname>Mattei</surname><given-names>M</given-names></name><name><surname>Muzi</surname><given-names>MG</given-names></name><name><surname>Canini</surname><given-names>A</given-names></name></person-group><article-title>Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression</article-title><source>Int J Oncol</source><year>2010</year><volume>37</volume><fpage>973</fpage><lpage>81</lpage><pub-id pub-id-type="pmid">20811719</pub-id></element-citation></ref><ref id="ref189"><label>189</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ren</surname><given-names>J</given-names></name><name><surname>Cheng</surname><given-names>H</given-names></name><name><surname>Xin</surname><given-names>WQ</given-names></name><name><surname>Chen</surname><given-names>X</given-names></name><name><surname>Hu</surname><given-names>K</given-names></name></person-group><article-title>Induction of apoptosis by 7-piperazinethylchrysin in HCT-116 human colon cancer cells</article-title><source>Oncol Rep</source><year>2012</year><volume>28</volume><fpage>1719</fpage><lpage>26</lpage><pub-id pub-id-type="pmid">22948973</pub-id></element-citation></ref><ref id="ref190"><label>190</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tsui</surname><given-names>KH</given-names></name><name><surname>Chung</surname><given-names>LC</given-names></name><name><surname>Feng</surname><given-names>TH</given-names></name><name><surname>Chang</surname><given-names>PL</given-names></name><name><surname>Juang</surname><given-names>HH</given-names></name></person-group><article-title>Upregulation of prostate-derived Ets factor by luteolin causes inhibition of cell proliferation and cell invasion in prostate carcinoma cells</article-title><source>Int J Cancer</source><year>2012</year><volume>130</volume><fpage>2812</fpage><lpage>23</lpage><pub-id pub-id-type="pmid">21780100</pub-id></element-citation></ref><ref id="ref191"><label>191</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chen</surname><given-names>KH</given-names></name><name><surname>Weng</surname><given-names>MS</given-names></name><name><surname>Lin</surname><given-names>JK</given-names></name></person-group><article-title>Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells</article-title><source>Biochem Pharmacol</source><year>2007</year><volume>73</volume><fpage>215</fpage><lpage>27</lpage><pub-id pub-id-type="pmid">17067555</pub-id></element-citation></ref><ref id="ref192"><label>192</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhang</surname><given-names>M</given-names></name><name><surname>Liu</surname><given-names>LP</given-names></name><name><surname>Chen</surname><given-names>Y</given-names></name><name><surname>Tian</surname><given-names>XY</given-names></name><name><surname>Qin</surname><given-names>J</given-names></name><name><surname>Wang</surname><given-names>D</given-names></name><etal></etal></person-group><article-title>Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax</article-title><source>Life Sci</source><year>2013</year><volume>92</volume><fpage>55</fpage><lpage>62</lpage><pub-id pub-id-type="pmid">23142241</pub-id></element-citation></ref><ref id="ref193"><label>193</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ciesielska</surname><given-names>E</given-names></name><name><surname>Gwardys</surname><given-names>A</given-names></name><name><surname>Metodiewa</surname><given-names>D</given-names></name></person-group><article-title>Anticancer, antiradical and antioxidative actions of novel Antoksyd S and its major components, baicalin and baicalein</article-title><source>Anticancer Res</source><year>2002</year><volume>22</volume><fpage>2885</fpage><lpage>91</lpage><pub-id pub-id-type="pmid">12530012</pub-id></element-citation></ref><ref id="ref194"><label>194</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>N</given-names></name><name><surname>Tang</surname><given-names>LJ</given-names></name><name><surname>Zhu</surname><given-names>GQ</given-names></name><name><surname>Peng</surname><given-names>DY</given-names></name><name><surname>Wang</surname><given-names>L</given-names></name><name><surname>Sun</surname><given-names>FN</given-names></name><etal></etal></person-group><article-title>Apoptosis induced by baicalin involving up-regulation of P53 and bax in MCF-7 cells</article-title><source>J Asian Nat Prod Res</source><year>2008</year><volume>10</volume><fpage>1129</fpage><lpage>35</lpage><pub-id pub-id-type="pmid">19031258</pub-id></element-citation></ref><ref id="ref195"><label>195</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chowdhury</surname><given-names>SA</given-names></name><name><surname>Kishino</surname><given-names>K</given-names></name><name><surname>Satoh</surname><given-names>R</given-names></name><name><surname>Hashimoto</surname><given-names>K</given-names></name><name><surname>Kikuchi</surname><given-names>H</given-names></name><name><surname>Nishikawa</surname><given-names>H</given-names></name><etal></etal></person-group><article-title>Tumor-specificity and apoptosis-inducing activity of stilbenes and flavonoids</article-title><source>Anticancer Res</source><year>2005</year><volume>25</volume><fpage>2055</fpage><lpage>63</lpage><pub-id pub-id-type="pmid">16158945</pub-id></element-citation></ref><ref id="ref196"><label>196</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Katalinić</surname><given-names>M</given-names></name><name><surname>Rusak</surname><given-names>G</given-names></name><name><surname>Domaćinović Barović</surname><given-names>J</given-names></name><name><surname>Sinko</surname><given-names>G</given-names></name><name><surname>Jelić</surname><given-names>D</given-names></name><name><surname>Antolović</surname><given-names>R</given-names></name><etal></etal></person-group><article-title>Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase</article-title><source>Eur J Med Chem</source><year>2010</year><volume>45</volume><fpage>186</fpage><lpage>92</lpage><pub-id pub-id-type="pmid">19879672</pub-id></element-citation></ref><ref id="ref197"><label>197</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Monasterio</surname><given-names>A</given-names></name><name><surname>Urdaci</surname><given-names>MC</given-names></name><name><surname>Pinchuk</surname><given-names>IV</given-names></name><name><surname>Lopez-Moratalla</surname><given-names>N</given-names></name><name><surname>Martinez-Irujo</surname><given-names>JJ</given-names></name></person-group><article-title>Flavonoids induce apoptosis in human leukemia U937 cells through caspase- and caspase-calpain-dependent pathways</article-title><source>Nutr Cancer</source><year>2004</year><volume>50</volume><fpage>90</fpage><lpage>100</lpage><pub-id pub-id-type="pmid">15572302</pub-id></element-citation></ref><ref id="ref198"><label>198</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Richter</surname><given-names>M</given-names></name><name><surname>Ebermann</surname><given-names>R</given-names></name><name><surname>Marian</surname><given-names>B</given-names></name></person-group><article-title>Quercetin-induced apoptosis in colorectal tumor cells: Possible role of EGF receptor signaling</article-title><source>Nutr Cancer</source><year>1999</year><volume>34</volume><fpage>88</fpage><lpage>99</lpage><pub-id pub-id-type="pmid">10453447</pub-id></element-citation></ref><ref id="ref199"><label>199</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kuntz</surname><given-names>S</given-names></name><name><surname>Wenzel</surname><given-names>U</given-names></name><name><surname>Daniel</surname><given-names>H</given-names></name></person-group><article-title>Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines</article-title><source>Eur J Nutr</source><year>1999</year><volume>38</volume><fpage>133</fpage><lpage>42</lpage><pub-id pub-id-type="pmid">10443335</pub-id></element-citation></ref><ref id="ref200"><label>200</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>SW</given-names></name><name><surname>Lee</surname><given-names>JT</given-names></name><name><surname>Lee</surname><given-names>MG</given-names></name><name><surname>Lee</surname><given-names>HW</given-names></name><name><surname>Ahn</surname><given-names>SJ</given-names></name><name><surname>Lee</surname><given-names>YJ</given-names></name><etal></etal></person-group><article-title><italic>In vitro</italic> antiproliferative characteristics of flavonoids and diazepam on SNU-C4 colorectal adenocarcinoma cells</article-title><source>J Nat Med</source><year>2009</year><volume>63</volume><fpage>124</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">19050992</pub-id></element-citation></ref><ref id="ref201"><label>201</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kim</surname><given-names>DH</given-names></name><name><surname>Lee</surname><given-names>JT</given-names></name><name><surname>Lee</surname><given-names>IK</given-names></name><name><surname>Ha</surname><given-names>JH</given-names></name></person-group><article-title>Comparative anticancer effects of flavonoids and diazepam in cultured cancer cells</article-title><source>Biol Pharm Bull</source><year>2008</year><volume>31</volume><fpage>255</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">18239283</pub-id></element-citation></ref><ref id="ref202"><label>202</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Murtaza</surname><given-names>I</given-names></name><name><surname>Adhami</surname><given-names>VM</given-names></name><name><surname>Hafeez</surname><given-names>BB</given-names></name><name><surname>Saleem</surname><given-names>M</given-names></name><name><surname>Mukhtar</surname><given-names>H</given-names></name></person-group><article-title>Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaB</article-title><source>Int J Cancer</source><year>2009</year><volume>125</volume><fpage>2465</fpage><lpage>73</lpage><pub-id pub-id-type="pmid">19670328</pub-id></element-citation></ref><ref id="ref203"><label>203</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Haddad</surname><given-names>AQ</given-names></name><name><surname>Venkateswaran</surname><given-names>V</given-names></name><name><surname>Viswanathan</surname><given-names>L</given-names></name><name><surname>Teahan</surname><given-names>SJ</given-names></name><name><surname>Fleshner</surname><given-names>NE</given-names></name><name><surname>Klotz</surname><given-names>LH</given-names></name></person-group><article-title>Novel antiproliferative flavonoids induce cell cycle arrest in human prostate cancer cell lines</article-title><source>Prostate Cancer Prostatic Dis</source><year>2006</year><volume>9</volume><fpage>68</fpage><lpage>76</lpage><pub-id pub-id-type="pmid">16314891</pub-id></element-citation></ref><ref id="ref204"><label>204</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ludwiczuk</surname><given-names>A</given-names></name><name><surname>Saha</surname><given-names>A</given-names></name><name><surname>Kuzuhara</surname><given-names>T</given-names></name><name><surname>Asakawa</surname><given-names>Y</given-names></name></person-group><article-title>Bioactivity guided isolation of anticancer constituents from leaves of Alnus sieboldiana (Betulaceae)</article-title><source>Phytomedicine</source><year>2011</year><volume>18</volume><fpage>491</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">21111588</pub-id></element-citation></ref><ref id="ref205"><label>205</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Brown</surname><given-names>J</given-names></name><name><surname>O’Prey</surname><given-names>J</given-names></name><name><surname>Harrison</surname><given-names>PR</given-names></name></person-group><article-title>Enhanced sensitivity of human oral tumours to the flavonol, morin, during cancer progression: Involvement of the Akt and stress kinase pathways</article-title><source>Carcinogenesis</source><year>2003</year><volume>24</volume><fpage>171</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">12584164</pub-id></element-citation></ref><ref id="ref206"><label>206</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>F</given-names></name><name><surname>Awale</surname><given-names>S</given-names></name><name><surname>Tezuka</surname><given-names>Y</given-names></name><name><surname>Esumi</surname><given-names>H</given-names></name><name><surname>Kadota</surname><given-names>S</given-names></name></person-group><article-title>Study on the constituents of Mexican propolis and their cytotoxic activity against PANC-1 human pancreatic cancer cells</article-title><source>J Nat Prod</source><year>2010</year><volume>73</volume><fpage>623</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">20307087</pub-id></element-citation></ref><ref id="ref207"><label>207</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bai</surname><given-names>N</given-names></name><name><surname>He</surname><given-names>K</given-names></name><name><surname>Roller</surname><given-names>M</given-names></name><name><surname>Lai</surname><given-names>CS</given-names></name><name><surname>Shao</surname><given-names>X</given-names></name><name><surname>Pan</surname><given-names>MH</given-names></name><etal></etal></person-group><article-title>Flavonoids and phenolic compounds from Rosmarinus officinalis</article-title><source>J Argic Food Chem</source><year>2010</year><volume>58</volume><fpage>5363</fpage><lpage>7</lpage></element-citation></ref><ref id="ref208"><label>208</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dickancaité</surname><given-names>E</given-names></name><name><surname>Nemeikaitè</surname><given-names>A</given-names></name><name><surname>Kalvelytè</surname><given-names>A</given-names></name><name><surname>Cènas</surname><given-names>N</given-names></name></person-group><article-title>Prooxidant character of flavonoid cytotoxicity: Structure-activity relationships</article-title><source>Biochem Mol Biol Int</source><year>1998</year><volume>45</volume><fpage>923</fpage><lpage>30</lpage><pub-id pub-id-type="pmid">9739457</pub-id></element-citation></ref><ref id="ref209"><label>209</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lin</surname><given-names>CM</given-names></name><name><surname>Chen</surname><given-names>CT</given-names></name><name><surname>Lee</surname><given-names>HH</given-names></name><name><surname>Lin</surname><given-names>JK</given-names></name></person-group><article-title>Prevention of cellular ROS damage by isovitexin and related flavonoids</article-title><source>Planta Med</source><year>2002</year><volume>68</volume><fpage>365</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">11988866</pub-id></element-citation></ref><ref id="ref210"><label>210</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rusak</surname><given-names>G</given-names></name><name><surname>Gutzeit</surname><given-names>HO</given-names></name><name><surname>Müller</surname><given-names>JL</given-names></name></person-group><article-title>Structurally related flavonoids with antioxidative properties differentially affect cell cycle progression and apoptosis of human acute leukemia cells</article-title><source>Nutr Res</source><year>2005</year><volume>25</volume><fpage>143</fpage><lpage>55</lpage></element-citation></ref><ref id="ref211"><label>211</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rao</surname><given-names>YK</given-names></name><name><surname>Geethangili</surname><given-names>M</given-names></name><name><surname>Fang</surname><given-names>SH</given-names></name><name><surname>Tzeng</surname><given-names>YM</given-names></name></person-group><article-title>Antioxidant and cytotoxic activities of naturally occurring phenolic and related compounds: A comparative study</article-title><source>Food Chem Toxicol</source><year>2007</year><volume>45</volume><fpage>1770</fpage><lpage>6</lpage><pub-id pub-id-type="pmid">17475387</pub-id></element-citation></ref><ref id="ref212"><label>212</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bigović</surname><given-names>D</given-names></name><name><surname>Savikin</surname><given-names>K</given-names></name><name><surname>Janković</surname><given-names>T</given-names></name><name><surname>Menković</surname><given-names>N</given-names></name><name><surname>Zdunić</surname><given-names>G</given-names></name><name><surname>Stanojković</surname><given-names>T</given-names></name><etal></etal></person-group><article-title>Antiradical and cytotoxic activity of different Helichrysum plicatum flower extracts</article-title><source>Nat Prod Commun</source><year>2011</year><volume>6</volume><fpage>819</fpage><lpage>22</lpage><pub-id pub-id-type="pmid">21815418</pub-id></element-citation></ref><ref id="ref213"><label>213</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huang</surname><given-names>WW</given-names></name><name><surname>Chiu</surname><given-names>YJ</given-names></name><name><surname>Fan</surname><given-names>MJ</given-names></name><name><surname>Lu</surname><given-names>HF</given-names></name><name><surname>Yeh</surname><given-names>HF</given-names></name><name><surname>Li</surname><given-names>KH</given-names></name><etal></etal></person-group><article-title>Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells</article-title><source>Mol Nutr Food Res</source><year>2010</year><volume>54</volume><fpage>1585</fpage><lpage>95</lpage><pub-id pub-id-type="pmid">20564475</pub-id></element-citation></ref><ref id="ref214"><label>214</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>C</given-names></name><name><surname>Kurzer</surname><given-names>MS</given-names></name></person-group><article-title>Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cells</article-title><source>Nutr Cancer</source><year>1997</year><volume>28</volume><fpage>236</fpage><lpage>47</lpage><pub-id pub-id-type="pmid">9343831</pub-id></element-citation></ref><ref id="ref215"><label>215</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Balabhadrapathruni</surname><given-names>S</given-names></name><name><surname>Thomas</surname><given-names>TJ</given-names></name><name><surname>Yurkow</surname><given-names>EJ</given-names></name><name><surname>Amenta</surname><given-names>PS</given-names></name><name><surname>Thomas</surname><given-names>T</given-names></name></person-group><article-title>Effects of genistein and structurally related phytoestrogens on cell cycle kinetics and apoptosis in MDA-MB-468 human breast cancer cells</article-title><source>Oncol Rep</source><year>2000</year><volume>7</volume><fpage>3</fpage><lpage>12</lpage><pub-id pub-id-type="pmid">10601582</pub-id></element-citation></ref><ref id="ref216"><label>216</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Phromnoi</surname><given-names>K</given-names></name><name><surname>Yodkeeree</surname><given-names>S</given-names></name><name><surname>Anuchapreeda</surname><given-names>S</given-names></name><name><surname>Limtrakul</surname><given-names>P</given-names></name></person-group><article-title>Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids</article-title><source>Acta Pharmacol Sin</source><year>2009</year><volume>30</volume><fpage>1169</fpage><lpage>76</lpage><pub-id pub-id-type="pmid">19617894</pub-id></element-citation></ref><ref id="ref217"><label>217</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Manthey</surname><given-names>JA</given-names></name><name><surname>Guthrie</surname><given-names>N</given-names></name></person-group><article-title>Antiproliferative activities of citrus flavonoids against six human cancer cell lines</article-title><source>J Argic Food Chem</source><year>2002</year><volume>50</volume><fpage>5837</fpage><lpage>43</lpage></element-citation></ref><ref id="ref218"><label>218</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Loizzo</surname><given-names>MR</given-names></name><name><surname>Said</surname><given-names>A</given-names></name><name><surname>Tundis</surname><given-names>R</given-names></name><name><surname>Hawas</surname><given-names>UW</given-names></name><name><surname>Rashed</surname><given-names>K</given-names></name><name><surname>Menichini</surname><given-names>F</given-names></name><etal></etal></person-group><article-title>Antioxidant and antiproliferative activity of Diospyros lotus L. extract and isolated compounds</article-title><source>Plant Foods Hum Nutr</source><year>2009</year><volume>64</volume><fpage>264</fpage><lpage>70</lpage><pub-id pub-id-type="pmid">19731038</pub-id></element-citation></ref><ref id="ref219"><label>219</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kim</surname><given-names>YK</given-names></name><name><surname>Kim</surname><given-names>YS</given-names></name><name><surname>Choi</surname><given-names>SU</given-names></name><name><surname>Ryu</surname><given-names>SY</given-names></name></person-group><article-title>Isolation of flavonol rhamnosides from Loranthus tanakae and cytotoxic effect of them on human tumor cell lines</article-title><source>Arch Pharm Res</source><year>2004</year><volume>27</volume><fpage>44</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">14969337</pub-id></element-citation></ref><ref id="ref220"><label>220</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kwak</surname><given-names>JH</given-names></name><name><surname>Kang</surname><given-names>MW</given-names></name><name><surname>Roh</surname><given-names>JH</given-names></name><name><surname>Choi</surname><given-names>SU</given-names></name><name><surname>Zee</surname><given-names>OP</given-names></name></person-group><article-title>Cytotoxic phenolic compounds from Chionanthus retusus</article-title><source>Arch Pharm Res</source><year>2009</year><volume>32</volume><fpage>1681</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">20162394</pub-id></element-citation></ref><ref id="ref221"><label>221</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Loa</surname><given-names>J</given-names></name><name><surname>Chow</surname><given-names>P</given-names></name><name><surname>Zhang</surname><given-names>K</given-names></name></person-group><article-title>Studies of structure-activity relationship on plant polyphenol-induced suppression of human liver cancer cells</article-title><source>Cancer Chemother Pharmacol</source><year>2009</year><volume>63</volume><fpage>1007</fpage><lpage>16</lpage><pub-id pub-id-type="pmid">18766342</pub-id></element-citation></ref><ref id="ref222"><label>222</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Said</surname><given-names>A</given-names></name><name><surname>Tundis</surname><given-names>R</given-names></name><name><surname>Hawas</surname><given-names>UW</given-names></name><name><surname>El-Kousy</surname><given-names>SM</given-names></name><name><surname>Rashed</surname><given-names>K</given-names></name><name><surname>Menichini</surname><given-names>F</given-names></name><etal></etal></person-group><article-title><italic>In vitro</italic> antioxidant and antiproliferative activities of flavonoids from Ailanthus excelsa (Roxb.) (Simaroubaceae) leaves</article-title><source>Z Naturforsch C</source><year>2010</year><volume>65</volume><fpage>180</fpage><lpage>6</lpage><pub-id pub-id-type="pmid">20469635</pub-id></element-citation></ref><ref id="ref223"><label>223</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nguyen</surname><given-names>TT</given-names></name><name><surname>Tran</surname><given-names>E</given-names></name><name><surname>Ong</surname><given-names>CK</given-names></name><name><surname>Lee</surname><given-names>SK</given-names></name><name><surname>Do</surname><given-names>PT</given-names></name><name><surname>Huynh</surname><given-names>TT</given-names></name><etal></etal></person-group><article-title>Kaempferol-induced growth inhibition and apoptosis in A549 lung cancer cells is mediated by activation of MEK-MAPK</article-title><source>J Cell Physiol</source><year>2003</year><volume>197</volume><fpage>110</fpage><lpage>21</lpage><pub-id pub-id-type="pmid">12942547</pub-id></element-citation></ref><ref id="ref224"><label>224</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Casagrande</surname><given-names>F</given-names></name><name><surname>Darbon</surname><given-names>JM</given-names></name></person-group><article-title>Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: Regulation of cyclin-dependent kinases CDK2 and CDK1</article-title><source>Biochem Pharmacol</source><year>2001</year><volume>61</volume><fpage>1205</fpage><lpage>15</lpage><pub-id pub-id-type="pmid">11322924</pub-id></element-citation></ref><ref id="ref225"><label>225</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>O’Prey</surname><given-names>J</given-names></name><name><surname>Brown</surname><given-names>J</given-names></name><name><surname>Fleming</surname><given-names>J</given-names></name><name><surname>Harrison</surname><given-names>PR</given-names></name></person-group><article-title>Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells</article-title><source>Biochem Pharmacol</source><year>2003</year><volume>66</volume><fpage>2075</fpage><lpage>88</lpage><pub-id pub-id-type="pmid">14609732</pub-id></element-citation></ref><ref id="ref226"><label>226</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhang</surname><given-names>Q</given-names></name><name><surname>Zhao</surname><given-names>XH</given-names></name><name><surname>Wang</surname><given-names>ZJ</given-names></name></person-group><article-title>Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis</article-title><source>Food Chem Toxicol</source><year>2008</year><volume>46</volume><fpage>2042</fpage><lpage>53</lpage><pub-id pub-id-type="pmid">18331776</pub-id></element-citation></ref><ref id="ref227"><label>227</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhang</surname><given-names>Q</given-names></name><name><surname>Zhao</surname><given-names>XH</given-names></name><name><surname>Wang</surname><given-names>ZJ</given-names></name></person-group><article-title>Cytotoxicity of flavones and flavonols to a human oesophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis</article-title><source>Toxicol <italic>In Vitro</italic></source><year>2009</year><volume>23</volume><fpage>797</fpage><lpage>807</lpage><pub-id pub-id-type="pmid">19397994</pub-id></element-citation></ref><ref id="ref228"><label>228</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kawaii</surname><given-names>S</given-names></name><name><surname>Tomono</surname><given-names>Y</given-names></name><name><surname>Katase</surname><given-names>E</given-names></name><name><surname>Ogawa</surname><given-names>K</given-names></name><name><surname>Yano</surname><given-names>M</given-names></name></person-group><article-title>Antiproliferative activity of flavonoids on several cancer cell lines</article-title><source>Biosci Biotechnol Biochem</source><year>1999</year><volume>63</volume><fpage>896</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">10380632</pub-id></element-citation></ref><ref id="ref229"><label>229</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Freire</surname><given-names>AC</given-names></name><name><surname>da Silva Melo</surname><given-names>P</given-names></name><name><surname>Aoyama</surname><given-names>H</given-names></name><name><surname>Haun</surname><given-names>M</given-names></name><name><surname>Durán</surname><given-names>N</given-names></name><name><surname>Ferreira</surname><given-names>CV</given-names></name></person-group><article-title>Cytotoxic effect of the diterpene lactone dehydrocrotonin from Croton cajucara on human promyelocytic leukemia cells</article-title><source>Planta Med</source><year>2003</year><volume>69</volume><fpage>67</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">12567283</pub-id></element-citation></ref><ref id="ref230"><label>230</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Aherne</surname><given-names>SA</given-names></name><name><surname>O’Brien</surname><given-names>NM</given-names></name></person-group><article-title>Protection by the flavonoids myricetin, quercetin, and rutin against hydrogen peroxide-induced DNA damage in Caco-2 and Hep G2 cells</article-title><source>Nutr Cancer</source><year>1999</year><volume>34</volume><fpage>160</fpage><lpage>6</lpage><pub-id pub-id-type="pmid">10578483</pub-id></element-citation></ref><ref id="ref231"><label>231</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Newell</surname><given-names>AM</given-names></name><name><surname>Yousef</surname><given-names>GG</given-names></name><name><surname>Lila</surname><given-names>MA</given-names></name><name><surname>Ramirez-Mares</surname><given-names>MV</given-names></name><name><surname>de Mejia</surname><given-names>EG</given-names></name></person-group><article-title>Comparative <italic>in vitro</italic> bioactivities of tea extracts from six species of Ardisia and their effect on growth inhibition of HepG2 cells</article-title><source>J Ethnopharmacol</source><year>2010</year><volume>130</volume><fpage>536</fpage><lpage>44</lpage><pub-id pub-id-type="pmid">20561930</pub-id></element-citation></ref><ref id="ref232"><label>232</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yáñez</surname><given-names>J</given-names></name><name><surname>Vicente</surname><given-names>V</given-names></name><name><surname>Alcaraz</surname><given-names>M</given-names></name><name><surname>Castillo</surname><given-names>J</given-names></name><name><surname>Benavente-García</surname><given-names>O</given-names></name><name><surname>Canteras</surname><given-names>M</given-names></name><etal></etal></person-group><article-title>Cytotoxicity and antiproliferative activities of several phenolic compounds against three melanocytes cell lines: Relationship between structure and activity</article-title><source>Nutr Cancer</source><year>2004</year><volume>49</volume><fpage>191</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">15489212</pub-id></element-citation></ref><ref id="ref233"><label>233</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Xu</surname><given-names>R</given-names></name><name><surname>Zhang</surname><given-names>Y</given-names></name><name><surname>Ye</surname><given-names>X</given-names></name><name><surname>Xue</surname><given-names>S</given-names></name><name><surname>Shi</surname><given-names>J</given-names></name><name><surname>Pan</surname><given-names>J</given-names></name><etal></etal></person-group><article-title>Inhibition effects and induction of apoptosis of flavonoids on the prostate cancer cell line PC-3 <italic>in vitro</italic></article-title><source>Food Chem</source><year>2013</year><volume>138</volume><fpage>48</fpage><lpage>53</lpage><pub-id pub-id-type="pmid">23265454</pub-id></element-citation></ref><ref id="ref234"><label>234</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lohezic-Le Dehevat</surname><given-names>F</given-names></name><name><surname>Tomasi</surname><given-names>S</given-names></name><name><surname>Fontanel</surname><given-names>D</given-names></name><name><surname>Boustie</surname><given-names>J</given-names></name></person-group><article-title>Flavonols from Scurrula Ferruginea Danser (Loranthaceae)</article-title><source>Z Naturforsch C</source><year>2002</year><volume>57</volume><fpage>1092</fpage><lpage>5</lpage><pub-id pub-id-type="pmid">12562100</pub-id></element-citation></ref><ref id="ref235"><label>235</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Simirgiotis</surname><given-names>MJ</given-names></name><name><surname>Adachi</surname><given-names>S</given-names></name><name><surname>To</surname><given-names>S</given-names></name><name><surname>Yang</surname><given-names>H</given-names></name><name><surname>Reynertson</surname><given-names>KA</given-names></name><name><surname>Basile</surname><given-names>MJ</given-names></name><etal></etal></person-group><article-title>Cytotoxic chalcones and antioxidants from the fruits of a Syzygium samarangense (Wax Jambu)</article-title><source>Food Chem</source><year>2008</year><volume>107</volume><fpage>813</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">22359426</pub-id></element-citation></ref><ref id="ref236"><label>236</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Browning</surname><given-names>AM</given-names></name><name><surname>Walle</surname><given-names>UK</given-names></name><name><surname>Walle</surname><given-names>T</given-names></name></person-group><article-title>Flavonoid glycosides inhibit oral cancer cell proliferation - role of cellular uptake and hydrolysis to the aglycones</article-title><source>J Pharm Pharmacol</source><year>2005</year><volume>57</volume><fpage>1037</fpage><lpage>42</lpage><pub-id pub-id-type="pmid">16102260</pub-id></element-citation></ref><ref id="ref237"><label>237</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chao</surname><given-names>JI</given-names></name><name><surname>Su</surname><given-names>WC</given-names></name><name><surname>Liu</surname><given-names>HF</given-names></name></person-group><article-title>Baicalein induces cancer cell death and proliferation retardation by the inhibition of CDC2 kinase and survivin associated with opposite role of p38 mitogen-activated protein kinase and AKT</article-title><source>Mol Cancer Ther</source><year>2007</year><volume>6</volume><fpage>3039</fpage><lpage>48</lpage><pub-id pub-id-type="pmid">18025287</pub-id></element-citation></ref><ref id="ref238"><label>238</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ramanathan</surname><given-names>R</given-names></name><name><surname>Tan</surname><given-names>CH</given-names></name><name><surname>Das</surname><given-names>NP</given-names></name></person-group><article-title>Cytotoxic effect of plant polyphenols and fat-soluble vitamins on malignant human cultured cells</article-title><source>Cancer Lett</source><year>1992</year><volume>62</volume><fpage>217</fpage><lpage>24</lpage><pub-id pub-id-type="pmid">1596866</pub-id></element-citation></ref><ref id="ref239"><label>239</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chen</surname><given-names>YH</given-names></name><name><surname>Chen</surname><given-names>HY</given-names></name><name><surname>Hsu</surname><given-names>CL</given-names></name><name><surname>Yen</surname><given-names>GC</given-names></name></person-group><article-title>Induction of apoptosis by the Lactuca indica L. in human leukemia cell line and its active components</article-title><source>J Agric Food Chem</source><year>2007</year><volume>55</volume><fpage>1743</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">17295517</pub-id></element-citation></ref><ref id="ref240"><label>240</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rhouma</surname><given-names>GB</given-names></name><name><surname>Chebil</surname><given-names>L</given-names></name><name><surname>Mustapha</surname><given-names>N</given-names></name><name><surname>Krifa</surname><given-names>M</given-names></name><name><surname>Ghedira</surname><given-names>K</given-names></name><name><surname>Ghoul</surname><given-names>M</given-names></name><etal></etal></person-group><article-title>Cytotoxic, genotoxic and antigenotoxic potencies of oligorutins</article-title><source>Hum Exp Toxicol</source><year>2013</year><volume>32</volume><fpage>881</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">23424216</pub-id></element-citation></ref><ref id="ref241"><label>241</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Goniotaki</surname><given-names>M</given-names></name><name><surname>Hatziantoniou</surname><given-names>S</given-names></name><name><surname>Dimas</surname><given-names>K</given-names></name><name><surname>Wagner</surname><given-names>M</given-names></name><name><surname>Demetzos</surname><given-names>C</given-names></name></person-group><article-title>Encapsulation of naturally occurring flavonoids into liposomes: Physicochemical properties and biological activity against human cancer cell lines</article-title><source>J Pharm Pharmacol</source><year>2004</year><volume>56</volume><fpage>1217</fpage><lpage>24</lpage><pub-id pub-id-type="pmid">15482635</pub-id></element-citation></ref><ref id="ref242"><label>242</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>L</given-names></name><name><surname>Henry</surname><given-names>GE</given-names></name><name><surname>Seeram</surname><given-names>NP</given-names></name></person-group><article-title>Identification and bioactivities of resveratrol oligomers and flavonoids from Carex folliculata seeds</article-title><source>J Agric Food Chem</source><year>2009</year><volume>57</volume><fpage>7282</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">19627089</pub-id></element-citation></ref><ref id="ref243"><label>243</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Alía</surname><given-names>M</given-names></name><name><surname>Mateos</surname><given-names>R</given-names></name><name><surname>Ramos</surname><given-names>S</given-names></name><name><surname>Lecumberri</surname><given-names>E</given-names></name><name><surname>Bravo</surname><given-names>L</given-names></name><name><surname>Goya</surname><given-names>L</given-names></name></person-group><article-title>Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2)</article-title><source>Eur J Nutr</source><year>2006</year><volume>45</volume><fpage>19</fpage><lpage>28</lpage><pub-id pub-id-type="pmid">15782287</pub-id></element-citation></ref><ref id="ref244"><label>244</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bellocco</surname><given-names>E</given-names></name><name><surname>Barreca</surname><given-names>D</given-names></name><name><surname>Laganà</surname><given-names>G</given-names></name><name><surname>Leuzzi</surname><given-names>U</given-names></name><name><surname>Tellone</surname><given-names>E</given-names></name><name><surname>Ficarra</surname><given-names>S</given-names></name><etal></etal></person-group><article-title>Influence of L-rhamnosyl-D-glycosyl derivatives on properties and biological interaction of flavonoids</article-title><source>Mol Cell Biochem</source><year>2009</year><volume>321</volume><fpage>165</fpage><lpage>71</lpage><pub-id pub-id-type="pmid">18987944</pub-id></element-citation></ref><ref id="ref245"><label>245</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ramos</surname><given-names>AA</given-names></name><name><surname>Lima</surname><given-names>CF</given-names></name><name><surname>Pereira</surname><given-names>ML</given-names></name><name><surname>Fernandes-Ferreira</surname><given-names>M</given-names></name><name><surname>Pereira-Wilson</surname><given-names>C</given-names></name></person-group><article-title>Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells: Evaluation by the comet assay</article-title><source>Toxicol Lett</source><year>2008</year><volume>177</volume><fpage>66</fpage><lpage>73</lpage><pub-id pub-id-type="pmid">18276086</pub-id></element-citation></ref><ref id="ref246"><label>246</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tsai</surname><given-names>YC</given-names></name><name><surname>Lin</surname><given-names>CL</given-names></name><name><surname>Chen</surname><given-names>BH</given-names></name></person-group><article-title>Preparative chromatography of flavonoids and saponins in Gynostemma pentaphyllum and their antiproliferation effect on hepatoma cell</article-title><source>Phytomedicine</source><year>2010</year><volume>18</volume><fpage>2</fpage><lpage>10</lpage><pub-id pub-id-type="pmid">21036575</pub-id></element-citation></ref><ref id="ref247"><label>247</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wei</surname><given-names>XH</given-names></name><name><surname>Yang</surname><given-names>SJ</given-names></name><name><surname>Liang</surname><given-names>N</given-names></name><name><surname>Hu</surname><given-names>DY</given-names></name><name><surname>Jin</surname><given-names>LH</given-names></name><name><surname>Xue</surname><given-names>W</given-names></name><etal></etal></person-group><article-title>Chemical constituents of Caesalpinia decapetala (Roth) Alston</article-title><source>Molecules</source><year>2013</year><volume>18</volume><fpage>1325</fpage><lpage>36</lpage><pub-id pub-id-type="pmid">23340256</pub-id></element-citation></ref><ref id="ref248"><label>248</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fang</surname><given-names>SC</given-names></name><name><surname>Hsu</surname><given-names>CL</given-names></name><name><surname>Lin</surname><given-names>HT</given-names></name><name><surname>Yen</surname><given-names>GC</given-names></name></person-group><article-title>Anticancer effects of flavonoid derivatives isolated from Millettia reticulata Benth in SK-Hep-1 human hepatocellular carcinoma cells</article-title><source>J Agric Food Chem</source><year>2010</year><volume>58</volume><fpage>814</fpage><lpage>20</lpage><pub-id pub-id-type="pmid">19994890</pub-id></element-citation></ref><ref id="ref249"><label>249</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Moghaddam</surname><given-names>G</given-names></name><name><surname>Ebrahimi</surname><given-names>SA</given-names></name><name><surname>Rahbar-Roshandel</surname><given-names>N</given-names></name><name><surname>Foroumadi</surname><given-names>A</given-names></name></person-group><article-title>Antiproliferative activity of flavonoids: Influence of the sequential methoxylation state of the flavonoid structure</article-title><source>Phytother Res</source><year>2012</year><volume>26</volume><fpage>1023</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">22184071</pub-id></element-citation></ref><ref id="ref250"><label>250</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hakimuddin</surname><given-names>F</given-names></name><name><surname>Paliyath</surname><given-names>G</given-names></name><name><surname>Meckling</surname><given-names>K</given-names></name></person-group><article-title>Selective cytotoxicity of a red grape wine flavonoid fraction against MCF-7 cells</article-title><source>Breast Cancer Res Treat</source><year>2004</year><volume>85</volume><fpage>65</fpage><lpage>79</lpage><pub-id pub-id-type="pmid">15039598</pub-id></element-citation></ref><ref id="ref251"><label>251</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Miranda</surname><given-names>CL</given-names></name><name><surname>Stevens</surname><given-names>JF</given-names></name><name><surname>Helmrich</surname><given-names>A</given-names></name><name><surname>Henderson</surname><given-names>MC</given-names></name><name><surname>Rodriguez</surname><given-names>RJ</given-names></name><name><surname>Yang</surname><given-names>YH</given-names></name><etal></etal></person-group><article-title>Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines</article-title><source>Food Chem Toxicol</source><year>1999</year><volume>37</volume><fpage>271</fpage><lpage>85</lpage><pub-id pub-id-type="pmid">10418944</pub-id></element-citation></ref><ref id="ref252"><label>252</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>So</surname><given-names>FV</given-names></name><name><surname>Guthrie</surname><given-names>N</given-names></name><name><surname>Chambers</surname><given-names>AF</given-names></name><name><surname>Carroll</surname><given-names>KK</given-names></name></person-group><article-title>Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen</article-title><source>Cancer Lett</source><year>1997</year><volume>112</volume><fpage>127</fpage><lpage>33</lpage><pub-id pub-id-type="pmid">9066718</pub-id></element-citation></ref><ref id="ref253"><label>253</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yelani</surname><given-names>T</given-names></name><name><surname>Hussein</surname><given-names>AA</given-names></name><name><surname>Meyer</surname><given-names>JJ</given-names></name></person-group><article-title>Isolation and identification of poisonous triterpenoids from Elaeodendron croceum</article-title><source>Nat Prod Res</source><year>2010</year><volume>24</volume><fpage>1418</fpage><lpage>25</lpage><pub-id pub-id-type="pmid">20234972</pub-id></element-citation></ref><ref id="ref254"><label>254</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>So</surname><given-names>FV</given-names></name><name><surname>Guthrie</surname><given-names>N</given-names></name><name><surname>Chambers</surname><given-names>AF</given-names></name><name><surname>Moussa</surname><given-names>M</given-names></name><name><surname>Carroll</surname><given-names>KK</given-names></name></person-group><article-title>Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices</article-title><source>Nutr Cancer</source><year>1996</year><volume>26</volume><fpage>167</fpage><lpage>81</lpage><pub-id pub-id-type="pmid">8875554</pub-id></element-citation></ref><ref id="ref255"><label>255</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jin</surname><given-names>CY</given-names></name><name><surname>Park</surname><given-names>C</given-names></name><name><surname>Hwang</surname><given-names>HJ</given-names></name><name><surname>Kim</surname><given-names>GY</given-names></name><name><surname>Choi</surname><given-names>BT</given-names></name><name><surname>Kim</surname><given-names>WJ</given-names></name><etal></etal></person-group><article-title>Naringenin up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer A549 cells</article-title><source>Mol Nutr Food Res</source><year>2011</year><volume>55</volume><fpage>300</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">20669244</pub-id></element-citation></ref><ref id="ref256"><label>256</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jeon</surname><given-names>SH</given-names></name><name><surname>Chun</surname><given-names>W</given-names></name><name><surname>Choi</surname><given-names>YJ</given-names></name><name><surname>Kwon</surname><given-names>YS</given-names></name></person-group><article-title>Cytotoxic constituents from the bark of Salix hulteni</article-title><source>Arch Pharm Res</source><year>2008</year><volume>31</volume><fpage>978</fpage><lpage>82</lpage><pub-id pub-id-type="pmid">18787784</pub-id></element-citation></ref><ref id="ref257"><label>257</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Alshatwi</surname><given-names>AA</given-names></name><name><surname>Ramesh</surname><given-names>E</given-names></name><name><surname>Periasamy</surname><given-names>VS</given-names></name><name><surname>Subash-Babu</surname><given-names>P</given-names></name></person-group><article-title>The apoptotic effect of hesperetin on human cervical cancer cells is mediated through cell cycle arrest, death receptor, and mitochondrial pathways</article-title><source>Fundam Clin Pharmacol</source><year>2013</year><volume>27</volume><fpage>581</fpage><lpage>92</lpage><pub-id pub-id-type="pmid">22913657</pub-id></element-citation></ref><ref id="ref258"><label>258</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>CJ</given-names></name><name><surname>Wilson</surname><given-names>L</given-names></name><name><surname>Jordan</surname><given-names>MA</given-names></name><name><surname>Nguyen</surname><given-names>V</given-names></name><name><surname>Tang</surname><given-names>J</given-names></name><name><surname>Smiyun</surname><given-names>G</given-names></name></person-group><article-title>Hesperidin suppressed proliferations of both human breast cancer and androgen-dependent prostate cancer cells</article-title><source>Phytother Res</source><year>2010</year><volume>24</volume><issue>Suppl 1</issue><fpage>S15</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">19548283</pub-id></element-citation></ref><ref id="ref259"><label>259</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ruela-de-Sousa</surname><given-names>RR</given-names></name><name><surname>Fuhler</surname><given-names>GM</given-names></name><name><surname>Blom</surname><given-names>N</given-names></name><name><surname>Ferreira</surname><given-names>CV</given-names></name><name><surname>Aoyama</surname><given-names>H</given-names></name><name><surname>Peppelenbosch</surname><given-names>MP</given-names></name></person-group><article-title>Cytotoxicity of apigenin on leukemia cell lines: Implications for prevention and therapy</article-title><source>Cell Death Dis</source><year>2010</year><volume>1</volume><fpage>e19</fpage><pub-id pub-id-type="pmid">21364620</pub-id></element-citation></ref><ref id="ref260"><label>260</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Vargo</surname><given-names>MA</given-names></name><name><surname>Voss</surname><given-names>OH</given-names></name><name><surname>Poustka</surname><given-names>F</given-names></name><name><surname>Cardounel</surname><given-names>AJ</given-names></name><name><surname>Grotewold</surname><given-names>E</given-names></name><name><surname>Doseff</surname><given-names>AI</given-names></name></person-group><article-title>Apigenin-induced-spoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells</article-title><source>Biochem Pharmacol</source><year>2006</year><volume>72</volume><fpage>681</fpage><lpage>92</lpage><pub-id pub-id-type="pmid">16844095</pub-id></element-citation></ref><ref id="ref261"><label>261</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sonoda</surname><given-names>M</given-names></name><name><surname>Nishiyama</surname><given-names>T</given-names></name><name><surname>Matsukawa</surname><given-names>Y</given-names></name><name><surname>Moriyasu</surname><given-names>M</given-names></name></person-group><article-title>Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine</article-title><source>J Ethnopharmacol</source><year>2004</year><volume>91</volume><fpage>65</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">15036470</pub-id></element-citation></ref><ref id="ref262"><label>262</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zheng</surname><given-names>PW</given-names></name><name><surname>Chaing</surname><given-names>LC</given-names></name><name><surname>Lin</surname><given-names>CC</given-names></name></person-group><article-title>Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells</article-title><source>Life Sci</source><year>2005</year><volume>76</volume><fpage>1367</fpage><lpage>79</lpage><pub-id pub-id-type="pmid">15670616</pub-id></element-citation></ref><ref id="ref263"><label>263</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chen</surname><given-names>D</given-names></name><name><surname>Landis-Piwowar</surname><given-names>KR</given-names></name><name><surname>Chen</surname><given-names>MS</given-names></name><name><surname>Dou</surname><given-names>QP</given-names></name></person-group><article-title>Inhibition of proteasome activity by the dietary flavonoid apigenin is associated with growth inhibition in cultured breast cancer cells and xenografts</article-title><source>Breast Cancer Res</source><year>2007</year><volume>9</volume><fpage>R80</fpage><pub-id pub-id-type="pmid">18300387</pub-id></element-citation></ref><ref id="ref264"><label>264</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Choi</surname><given-names>EJ</given-names></name><name><surname>Kim</surname><given-names>GH</given-names></name></person-group><article-title>Apigenin induces apoptosis through a mitochondria/caspase-pathway in human breast cancer MDA-MB-453 cells</article-title><source>J Clin Biochem Nutr</source><year>2009</year><volume>44</volume><fpage>260</fpage><lpage>5</lpage><pub-id pub-id-type="pmid">19430615</pub-id></element-citation></ref><ref id="ref265"><label>265</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Choi</surname><given-names>EJ</given-names></name><name><surname>Kim</surname><given-names>GH</given-names></name></person-group><article-title>5-Fluorouracil combined with apigenin enhances anticancer activity through induction of apoptosis in human breast cancer MDA-MB-453 cells</article-title><source>Oncol Rep</source><year>2009</year><volume>22</volume><fpage>1533</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">19885610</pub-id></element-citation></ref><ref id="ref266"><label>266</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Salama</surname><given-names>MM</given-names></name><name><surname>Kandil</surname><given-names>ZA</given-names></name><name><surname>Islam</surname><given-names>WT</given-names></name></person-group><article-title>Cytotoxic compounds from the leaves of Gaillardia aristata Pursh. growing in Egypt</article-title><source>Nat Prod Res</source><year>2012</year><volume>26</volume><fpage>2057</fpage><lpage>62</lpage><pub-id pub-id-type="pmid">21846263</pub-id></element-citation></ref><ref id="ref267"><label>267</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Forgo</surname><given-names>P</given-names></name><name><surname>Zupkó</surname><given-names>I</given-names></name><name><surname>Molnár</surname><given-names>J</given-names></name><name><surname>Vasas</surname><given-names>A</given-names></name><name><surname>Dombi</surname><given-names>G</given-names></name><name><surname>Hohmann</surname><given-names>J</given-names></name></person-group><article-title>Bioactivity-guided isolation of antiproliferative compounds from Centaurea jacea L</article-title><source>Fitoterapia</source><year>2012</year><volume>83</volume><fpage>921</fpage><lpage>5</lpage><pub-id pub-id-type="pmid">22537643</pub-id></element-citation></ref><ref id="ref268"><label>268</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hirano</surname><given-names>T</given-names></name><name><surname>Oka</surname><given-names>K</given-names></name><name><surname>Akiba</surname><given-names>M</given-names></name></person-group><article-title>Antiproliferative effects of synthetic and naturally occurring flavonoids on tumor cells of the human breast carcinoma cell line, ZR-75-1</article-title><source>Res Commun Chem Pathol Pharmacol</source><year>1989</year><volume>64</volume><fpage>69</fpage><lpage>78</lpage><pub-id pub-id-type="pmid">2749004</pub-id></element-citation></ref><ref id="ref269"><label>269</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lindenmeyer</surname><given-names>F</given-names></name><name><surname>Li</surname><given-names>H</given-names></name><name><surname>Menashi</surname><given-names>S</given-names></name><name><surname>Soria</surname><given-names>C</given-names></name><name><surname>Lu</surname><given-names>H</given-names></name></person-group><article-title>Apigenin acts on the tumor cell invasion process and regulates protease production</article-title><source>Nutr Cancer</source><year>2001</year><volume>39</volume><fpage>139</fpage><lpage>47</lpage><pub-id pub-id-type="pmid">11588896</pub-id></element-citation></ref><ref id="ref270"><label>270</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cardenas</surname><given-names>M</given-names></name><name><surname>Marder</surname><given-names>M</given-names></name><name><surname>Blank</surname><given-names>VC</given-names></name><name><surname>Roguin</surname><given-names>LP</given-names></name></person-group><article-title>Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines</article-title><source>Bioorg Med Chem</source><year>2006</year><volume>14</volume><fpage>2966</fpage><lpage>71</lpage><pub-id pub-id-type="pmid">16412650</pub-id></element-citation></ref><ref id="ref271"><label>271</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Csupor-Löffler</surname><given-names>B</given-names></name><name><surname>Hajdú</surname><given-names>Z</given-names></name><name><surname>Zupkó</surname><given-names>I</given-names></name><name><surname>Molnár</surname><given-names>J</given-names></name><name><surname>Forgo</surname><given-names>P</given-names></name><name><surname>Vasas</surname><given-names>A</given-names></name><etal></etal></person-group><article-title>Antiproliferative constituents of the roots of Conyza canadensis</article-title><source>Planta Med</source><year>2011</year><volume>77</volume><fpage>1183</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">21294076</pub-id></element-citation></ref><ref id="ref272"><label>272</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Csupor-Löffler</surname><given-names>B</given-names></name><name><surname>Hajdú</surname><given-names>Z</given-names></name><name><surname>Zupkó</surname><given-names>I</given-names></name><name><surname>Réthy</surname><given-names>B</given-names></name><name><surname>Falkay</surname><given-names>G</given-names></name><name><surname>Forgo</surname><given-names>P</given-names></name><etal></etal></person-group><article-title>Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines</article-title><source>Phytother Res</source><year>2009</year><volume>23</volume><fpage>672</fpage><lpage>6</lpage><pub-id pub-id-type="pmid">19107850</pub-id></element-citation></ref><ref id="ref273"><label>273</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Csapi</surname><given-names>B</given-names></name><name><surname>Hajdú</surname><given-names>Z</given-names></name><name><surname>Zupkó</surname><given-names>I</given-names></name><name><surname>Berényi</surname><given-names>A</given-names></name><name><surname>Forgo</surname><given-names>P</given-names></name><name><surname>Szabó</surname><given-names>P</given-names></name><etal></etal></person-group><article-title>Bioactivity-guided isolation of antiproliferative compounds from Centaurea arenaria</article-title><source>Phytother Res</source><year>2010</year><volume>24</volume><fpage>1664</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">21031625</pub-id></element-citation></ref><ref id="ref274"><label>274</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fullas</surname><given-names>F</given-names></name><name><surname>Hussain</surname><given-names>RA</given-names></name><name><surname>Chai</surname><given-names>HB</given-names></name><name><surname>Pezzuto</surname><given-names>JM</given-names></name><name><surname>Soejarto</surname><given-names>DD</given-names></name><name><surname>Kinghorn</surname><given-names>AD</given-names></name></person-group><article-title>Cytotoxic constituents of Baccharis gaudichaudiana</article-title><source>J Nat Prod</source><year>1994</year><volume>57</volume><fpage>801</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">7931367</pub-id></element-citation></ref><ref id="ref275"><label>275</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chiang</surname><given-names>LC</given-names></name><name><surname>Ng</surname><given-names>LT</given-names></name><name><surname>Lin</surname><given-names>IC</given-names></name><name><surname>Kup</surname><given-names>PL</given-names></name><name><surname>Lin</surname><given-names>CC</given-names></name></person-group><article-title>Anti-proliferative effect of apigenin and its apoptotic induction in human Hep G2 cells</article-title><source>Cancer Lett</source><year>2006</year><volume>237</volume><fpage>207</fpage><lpage>14</lpage><pub-id pub-id-type="pmid">16023288</pub-id></element-citation></ref><ref id="ref276"><label>276</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yee</surname><given-names>SB</given-names></name><name><surname>Lee</surname><given-names>JH</given-names></name><name><surname>Chung</surname><given-names>HY</given-names></name><name><surname>Im</surname><given-names>KS</given-names></name><name><surname>Bae</surname><given-names>SJ</given-names></name><name><surname>Choi</surname><given-names>JS</given-names></name><etal></etal></person-group><article-title>Inhibitory effects of luteolin isolated from Ixeris sonchifolia Hance on the proliferation of HepG2 human hepatocellular carcinoma cells</article-title><source>Arch Pharm Res</source><year>2003</year><volume>26</volume><fpage>151</fpage><lpage>6</lpage><pub-id pub-id-type="pmid">12643593</pub-id></element-citation></ref><ref id="ref277"><label>277</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Das</surname><given-names>S</given-names></name><name><surname>Sas</surname><given-names>J</given-names></name><name><surname>Samadder</surname><given-names>A</given-names></name><name><surname>Boujedaini</surname><given-names>N</given-names></name><name><surname>Khuda-Bukhsh</surname><given-names>AR</given-names></name></person-group><article-title>Apigenin-induced apoptosis in A375 and A549 cells through selective action and dysfunction of mitochondria</article-title><source>Exp Biol Med (Maywood)</source><year>2012</year><volume>237</volume><fpage>1433</fpage><lpage>48</lpage><pub-id pub-id-type="pmid">23354402</pub-id></element-citation></ref><ref id="ref278"><label>278</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>King</surname><given-names>JC</given-names></name><name><surname>Lu</surname><given-names>QY</given-names></name><name><surname>Li</surname><given-names>G</given-names></name><name><surname>Moro</surname><given-names>A</given-names></name><name><surname>Takahashi</surname><given-names>H</given-names></name><name><surname>Chen</surname><given-names>M</given-names></name><etal></etal></person-group><article-title>Evidence for activation of mutated p53 by apigenin in human pancreatic cancer</article-title><source>Biochim Biophys Acta</source><year>2012</year><volume>1823</volume><fpage>593</fpage><lpage>604</lpage><pub-id pub-id-type="pmid">22227579</pub-id></element-citation></ref><ref id="ref279"><label>279</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ujiki</surname><given-names>MB</given-names></name><name><surname>Ding</surname><given-names>XZ</given-names></name><name><surname>Salabat</surname><given-names>MR</given-names></name><name><surname>Bentrem</surname><given-names>DJ</given-names></name><name><surname>Golkar</surname><given-names>L</given-names></name><name><surname>Milam</surname><given-names>B</given-names></name><etal></etal></person-group><article-title>Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest</article-title><source>Mol Cancer</source><year>2006</year><volume>5</volume><fpage>76</fpage><pub-id pub-id-type="pmid">17196098</pub-id></element-citation></ref><ref id="ref280"><label>280</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shukla</surname><given-names>S</given-names></name><name><surname>Gupta</surname><given-names>S</given-names></name></person-group><article-title>Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation</article-title><source>Free Radic Biol Med</source><year>2008</year><volume>44</volume><fpage>1833</fpage><lpage>45</lpage><pub-id pub-id-type="pmid">18342637</pub-id></element-citation></ref><ref id="ref281"><label>281</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shenouda</surname><given-names>NS</given-names></name><name><surname>Zhou</surname><given-names>C</given-names></name><name><surname>Browning</surname><given-names>JD</given-names></name><name><surname>Ansell</surname><given-names>PJ</given-names></name><name><surname>Sakla</surname><given-names>MS</given-names></name><name><surname>Lubahn</surname><given-names>DB</given-names></name><etal></etal></person-group><article-title>Phytoestrogens in common herbs regulate prostate cancer cell growth <italic>in vitro</italic></article-title><source>Nutr Cancer</source><year>2004</year><volume>49</volume><fpage>200</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">15489213</pub-id></element-citation></ref><ref id="ref282"><label>282</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chen</surname><given-names>SS</given-names></name><name><surname>Corteling</surname><given-names>R</given-names></name><name><surname>Stevanato</surname><given-names>L</given-names></name><name><surname>Sinden</surname><given-names>J</given-names></name></person-group><article-title>Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity: A role of immunomodulation in chemoprevention</article-title><source>Discov Med</source><year>2012</year><volume>14</volume><fpage>327</fpage><lpage>33</lpage><pub-id pub-id-type="pmid">23200064</pub-id></element-citation></ref><ref id="ref283"><label>283</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cherng</surname><given-names>JM</given-names></name><name><surname>Shieh</surname><given-names>DE</given-names></name><name><surname>Chiang</surname><given-names>W</given-names></name><name><surname>Chang</surname><given-names>MY</given-names></name><name><surname>Chiang</surname><given-names>LC</given-names></name></person-group><article-title>Chemopreventive effects of minor dietary constituents in common foods on human cancer cells</article-title><source>Biosci Biotechnol Biochem</source><year>2007</year><volume>71</volume><fpage>1500</fpage><lpage>4</lpage><pub-id pub-id-type="pmid">17587681</pub-id></element-citation></ref><ref id="ref284"><label>284</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Roy</surname><given-names>MK</given-names></name><name><surname>Nakahara</surname><given-names>K</given-names></name><name><surname>Na</surname><given-names>TV</given-names></name><name><surname>Trakoontivakorn</surname><given-names>G</given-names></name><name><surname>Takenaka</surname><given-names>M</given-names></name><name><surname>Isobe</surname><given-names>S</given-names></name><etal></etal></person-group><article-title>Baicalein, a flavonoid extracted from a metanolic extract of Oroxylum indicum inhibits proliferation of a cancer cell line <italic>in vitro</italic> via induction of apoptosis</article-title><source>Pharmazie</source><year>2007</year><volume>62</volume><fpage>149</fpage><lpage>53</lpage><pub-id pub-id-type="pmid">17341037</pub-id></element-citation></ref><ref id="ref285"><label>285</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ma</surname><given-names>Z</given-names></name><name><surname>Otsuyama</surname><given-names>K</given-names></name><name><surname>Liu</surname><given-names>S</given-names></name><name><surname>Abroun</surname><given-names>S</given-names></name><name><surname>Ishikawa</surname><given-names>H</given-names></name><name><surname>Tsuyama</surname><given-names>N</given-names></name><etal></etal></person-group><article-title>Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells</article-title><source>Blood</source><year>2005</year><volume>105</volume><fpage>3312</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">15626742</pub-id></element-citation></ref><ref id="ref286"><label>286</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ciesielska</surname><given-names>E</given-names></name><name><surname>Wolszczak</surname><given-names>M</given-names></name><name><surname>Gulanowski</surname><given-names>B</given-names></name><name><surname>Szulawska</surname><given-names>A</given-names></name><name><surname>Kochman</surname><given-names>A</given-names></name><name><surname>Metodiewa</surname><given-names>D</given-names></name></person-group><article-title><italic>In vitro</italic> antileukemic, antioxidant and prooxidant activities of Antoksyd S (C/E/XXI): A comparison with baicalin and baicalein</article-title><source>In Vivo</source><year>2004</year><volume>18</volume><fpage>497</fpage><lpage>503</lpage><pub-id pub-id-type="pmid">15369191</pub-id></element-citation></ref><ref id="ref287"><label>287</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ishii</surname><given-names>K</given-names></name><name><surname>Tanaka</surname><given-names>S</given-names></name><name><surname>Kagami</surname><given-names>K</given-names></name><name><surname>Henmi</surname><given-names>K</given-names></name><name><surname>Toyoda</surname><given-names>H</given-names></name><name><surname>Kaise</surname><given-names>T</given-names></name><etal></etal></person-group><article-title>Effects of naturally occurring polymethoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells</article-title><source>Cancer Invest</source><year>2010</year><volume>28</volume><fpage>220</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">19863351</pub-id></element-citation></ref><ref id="ref288"><label>288</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Austin</surname><given-names>CA</given-names></name><name><surname>Patel</surname><given-names>S</given-names></name><name><surname>Ono</surname><given-names>K</given-names></name><name><surname>Nakane</surname><given-names>H</given-names></name><name><surname>Fisher</surname><given-names>LM</given-names></name></person-group><article-title>Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives</article-title><source>Biochem J</source><year>1992</year><volume>282</volume><fpage>883</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">1313232</pub-id></element-citation></ref><ref id="ref289"><label>289</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bednar</surname><given-names>W</given-names></name><name><surname>Holzmann</surname><given-names>K</given-names></name><name><surname>Marian</surname><given-names>B</given-names></name></person-group><article-title>Assessing 12(S)-lipoxygenase inhibitory activity using colorectal cancer cells overexpressing the enzyme</article-title><source>Food Chem Toxicol</source><year>2007</year><volume>45</volume><fpage>508</fpage><lpage>14</lpage><pub-id pub-id-type="pmid">17027136</pub-id></element-citation></ref><ref id="ref290"><label>290</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Liang</surname><given-names>RR</given-names></name><name><surname>Zhang</surname><given-names>S</given-names></name><name><surname>Qi</surname><given-names>JA</given-names></name><name><surname>Wang</surname><given-names>ZD</given-names></name><name><surname>Li</surname><given-names>J</given-names></name><name><surname>Liu</surname><given-names>PJ</given-names></name><etal></etal></person-group><article-title>Preferential inhibition of hepatocellular carcinoma by the flavonoid Baicalein through blocking MEK-ERK signaling</article-title><source>Int J Oncol</source><year>2012</year><volume>41</volume><fpage>969</fpage><lpage>78</lpage><pub-id pub-id-type="pmid">22684543</pub-id></element-citation></ref><ref id="ref291"><label>291</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Matsuzaki</surname><given-names>Y</given-names></name><name><surname>Kurokawa</surname><given-names>N</given-names></name><name><surname>Terai</surname><given-names>S</given-names></name><name><surname>Matsumura</surname><given-names>Y</given-names></name><name><surname>Kobayashi</surname><given-names>N</given-names></name><name><surname>Okita</surname><given-names>K</given-names></name></person-group><article-title>Cell death induced by baicalein in human hepatocellular carcinoma cell lines</article-title><source>Jpn J Cancer Res</source><year>1996</year><volume>87</volume><fpage>170</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">8609066</pub-id></element-citation></ref><ref id="ref292"><label>292</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Motoo</surname><given-names>Y</given-names></name><name><surname>Sawaby</surname><given-names>N</given-names></name></person-group><article-title>Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma cell lines</article-title><source>Cancer Lett</source><year>1994</year><volume>86</volume><fpage>91</fpage><lpage>5</lpage><pub-id pub-id-type="pmid">7954360</pub-id></element-citation></ref><ref id="ref293"><label>293</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Leung</surname><given-names>HW</given-names></name><name><surname>Yang</surname><given-names>WH</given-names></name><name><surname>Lai</surname><given-names>MY</given-names></name><name><surname>Lin</surname><given-names>CJ</given-names></name><name><surname>Lee</surname><given-names>HZ</given-names></name></person-group><article-title>Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis</article-title><source>Food Chem Toxicol</source><year>2007</year><volume>45</volume><fpage>403</fpage><lpage>11</lpage><pub-id pub-id-type="pmid">17050058</pub-id></element-citation></ref><ref id="ref294"><label>294</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Boik</surname><given-names>JC</given-names></name><name><surname>Newman</surname><given-names>RA</given-names></name></person-group><article-title>A classification model to predict synergism/antagonism of cytotoxic mixtures using protein-drug docking scores</article-title><source>BMC Pharmacol</source><year>2008</year><volume>8</volume><fpage>13</fpage><pub-id pub-id-type="pmid">18664274</pub-id></element-citation></ref><ref id="ref295"><label>295</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cheng</surname><given-names>YH</given-names></name><name><surname>Li</surname><given-names>LA</given-names></name><name><surname>Lin</surname><given-names>P</given-names></name><name><surname>Cheng</surname><given-names>LC</given-names></name><name><surname>Hung</surname><given-names>CH</given-names></name><name><surname>Chang</surname><given-names>NW</given-names></name><etal></etal></person-group><article-title>Baicalein induces G1 arrest in oral cancer cells by enhancing the degradation of cyclin D1 and activating AhR to decrease Rb phosphorylation</article-title><source>Toxicol Appl Pharmacol</source><year>2012</year><volume>263</volume><fpage>360</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">22820424</pub-id></element-citation></ref><ref id="ref296"><label>296</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pidgeon</surname><given-names>GP</given-names></name><name><surname>Kandouz</surname><given-names>M</given-names></name><name><surname>Meram</surname><given-names>A</given-names></name><name><surname>Honn</surname><given-names>KV</given-names></name></person-group><article-title>Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells</article-title><source>Cancer Res</source><year>2002</year><volume>62</volume><fpage>2721</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">11980674</pub-id></element-citation></ref><ref id="ref297"><label>297</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pilátová</surname><given-names>M</given-names></name><name><surname>Stupáková</surname><given-names>V</given-names></name><name><surname>Varinská</surname><given-names>L</given-names></name><name><surname>Sarisský</surname><given-names>M</given-names></name><name><surname>Mirossay</surname><given-names>L</given-names></name><name><surname>Mirossay</surname><given-names>A</given-names></name><etal></etal></person-group><article-title>Effect of selected flavones on cancer and endothelial cells</article-title><source>Gen Physiol Biophys</source><year>2010</year><volume>29</volume><fpage>134</fpage><lpage>43</lpage><pub-id pub-id-type="pmid">20577025</pub-id></element-citation></ref><ref id="ref298"><label>298</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ai</surname><given-names>XH</given-names></name><name><surname>Zheng</surname><given-names>X</given-names></name><name><surname>Tang</surname><given-names>XQ</given-names></name><name><surname>Sun</surname><given-names>L</given-names></name><name><surname>Zhang</surname><given-names>YQ</given-names></name><name><surname>Qin</surname><given-names>Y</given-names></name><etal></etal></person-group><article-title>Induction of apoptosis of human gastric carcinoma SGC-7901 cell line by 5,7-dihydroxy-8-nitrochrysin <italic>in vitro</italic></article-title><source>World J Gastroenterol</source><year>2007</year><volume>13</volume><fpage>3824</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">17657836</pub-id></element-citation></ref><ref id="ref299"><label>299</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhang</surname><given-names>T</given-names></name><name><surname>Chen</surname><given-names>X</given-names></name><name><surname>Qu</surname><given-names>L</given-names></name><name><surname>Wu</surname><given-names>J</given-names></name><name><surname>Cui</surname><given-names>R</given-names></name><name><surname>Zhao</surname><given-names>Y</given-names></name></person-group><article-title>Chrysin and its phosphate ester inhibit cell proliferation and induce apoptosis in Hela cells</article-title><source>Bioorg Med Chem</source><year>2004</year><volume>12</volume><fpage>6097</fpage><lpage>105</lpage><pub-id pub-id-type="pmid">15519155</pub-id></element-citation></ref><ref id="ref300"><label>300</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lyu</surname><given-names>SY</given-names></name><name><surname>Park</surname><given-names>WB</given-names></name></person-group><article-title>Production of cytokine and NO by RAW 264.7 macrophages and PBMC <italic>in vitro</italic> incubation with flavonoids</article-title><source>Arch Pharm Res</source><year>2005</year><volume>28</volume><fpage>573</fpage><lpage>81</lpage><pub-id pub-id-type="pmid">15974445</pub-id></element-citation></ref><ref id="ref301"><label>301</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kilani-Jaziri</surname><given-names>S</given-names></name><name><surname>Neffati</surname><given-names>A</given-names></name><name><surname>Limem</surname><given-names>I</given-names></name><name><surname>Boubaker</surname><given-names>J</given-names></name><name><surname>Skandrani</surname><given-names>I</given-names></name><name><surname>Sghair</surname><given-names>MB</given-names></name><etal></etal></person-group><article-title>Relationship correlation of antioxidant and antiproliferative capacity of Cyperus rotundus products towards K562 erythroleukemia cells</article-title><source>Chem Biol Interact</source><year>2009</year><volume>181</volume><fpage>85</fpage><lpage>94</lpage><pub-id pub-id-type="pmid">19446539</pub-id></element-citation></ref><ref id="ref302"><label>302</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chiang</surname><given-names>LC</given-names></name><name><surname>Cianh</surname><given-names>W</given-names></name><name><surname>Chang</surname><given-names>MY</given-names></name><name><surname>Ng</surname><given-names>LT</given-names></name><name><surname>Lin</surname><given-names>CC</given-names></name></person-group><article-title>Antileukemic activity of selected natural products in Taiwan</article-title><source>Am J Chin Med</source><year>2003</year><volume>31</volume><fpage>37</fpage><lpage>46</lpage><pub-id pub-id-type="pmid">12723753</pub-id></element-citation></ref><ref id="ref303"><label>303</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Saleem</surname><given-names>A</given-names></name><name><surname>Husheem</surname><given-names>M</given-names></name><name><surname>Härkönen</surname><given-names>P</given-names></name><name><surname>Pihlaja</surname><given-names>K</given-names></name></person-group><article-title>Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula retz. fruit</article-title><source>J Ethnopharmacol</source><year>2002</year><volume>81</volume><fpage>327</fpage><lpage>36</lpage><pub-id pub-id-type="pmid">12127233</pub-id></element-citation></ref><ref id="ref304"><label>304</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Afifi</surname><given-names>FU</given-names></name><name><surname>Abu-Dahab</surname><given-names>R</given-names></name></person-group><article-title>Phytochemical screening and biological activities of Eminium spiculatum (Blume) Kuntze (family Araceae)</article-title><source>Nat Prod Res</source><year>2012</year><volume>26</volume><fpage>878</fpage><lpage>82</lpage><pub-id pub-id-type="pmid">21809948</pub-id></element-citation></ref><ref id="ref305"><label>305</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hsu</surname><given-names>HF</given-names></name><name><surname>Houng</surname><given-names>JY</given-names></name><name><surname>Chang</surname><given-names>CL</given-names></name><name><surname>Wu</surname><given-names>CC</given-names></name><name><surname>Chang</surname><given-names>FR</given-names></name><name><surname>Wu</surname><given-names>YC</given-names></name></person-group><article-title>Antioxidant activity, cytotoxicity, and DNA information of Glossogyne tenuifolia</article-title><source>J Agric Food Chem</source><year>2005</year><volume>53</volume><fpage>6117</fpage><lpage>25</lpage><pub-id pub-id-type="pmid">16029005</pub-id></element-citation></ref><ref id="ref306"><label>306</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lin</surname><given-names>AS</given-names></name><name><surname>Lin</surname><given-names>CR</given-names></name><name><surname>Du</surname><given-names>YC</given-names></name><name><surname>Lübken</surname><given-names>T</given-names></name><name><surname>Chiang</surname><given-names>MY</given-names></name><name><surname>Chen</surname><given-names>IH</given-names></name><etal></etal></person-group><article-title>Acasiane A and B and farnesirane A and B, diterpene derivatives from the roots of Acacia farnesiana</article-title><source>Planta Med</source><year>2009</year><volume>75</volume><fpage>256</fpage><lpage>61</lpage><pub-id pub-id-type="pmid">19101886</pub-id></element-citation></ref><ref id="ref307"><label>307</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wu</surname><given-names>J</given-names></name><name><surname>Yi</surname><given-names>W</given-names></name><name><surname>Jin</surname><given-names>L</given-names></name><name><surname>Hu</surname><given-names>D</given-names></name><name><surname>Song</surname><given-names>B</given-names></name></person-group><article-title>Antiproliferative and cell apoptosis-inducing activities of compounds from Buddleja davidii in Mgc-803 cells</article-title><source>Cell Div</source><year>2012</year><volume>7</volume><fpage>20</fpage><pub-id pub-id-type="pmid">22938042</pub-id></element-citation></ref><ref id="ref308"><label>308</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Xie</surname><given-names>YY</given-names></name><name><surname>Yuan</surname><given-names>D</given-names></name><name><surname>Yang</surname><given-names>JY</given-names></name><name><surname>Wang</surname><given-names>LH</given-names></name><name><surname>Wu</surname><given-names>CF</given-names></name></person-group><article-title>Cytotoxic activity of flavonoids from the flowers of Chrysanthemum morifolium on human colon cancer Colon205 cells</article-title><source>J Asian Nat Prod Res</source><year>2009</year><volume>11</volume><fpage>771</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">20183323</pub-id></element-citation></ref><ref id="ref309"><label>309</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>HJ</given-names></name><name><surname>Wang</surname><given-names>CJ</given-names></name><name><surname>Kuo</surname><given-names>HC</given-names></name><name><surname>Chou</surname><given-names>FP</given-names></name><name><surname>Jean</surname><given-names>LF</given-names></name><name><surname>Tseng</surname><given-names>TH</given-names></name></person-group><article-title>Induction apoptosis of luteolin in human hepatoma HepG2 cells involving mitochondria translocation of Bax/Bak and activation of JNK</article-title><source>Toxicol Appl Pharmacol</source><year>2005</year><volume>203</volume><fpage>124</fpage><lpage>31</lpage><pub-id pub-id-type="pmid">15710173</pub-id></element-citation></ref><ref id="ref310"><label>310</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yoo</surname><given-names>DR</given-names></name><name><surname>Jang</surname><given-names>YH</given-names></name><name><surname>Jeon</surname><given-names>YK</given-names></name><name><surname>Kim</surname><given-names>JY</given-names></name><name><surname>Jeon</surname><given-names>W</given-names></name><name><surname>Choi</surname><given-names>YJ</given-names></name><etal></etal></person-group><article-title>Proteomic identification of anti-cancer proteins in luteolin-treated human hepatoma Huh-7 cells</article-title><source>Cancer Lett</source><year>2009</year><volume>282</volume><fpage>48</fpage><lpage>54</lpage><pub-id pub-id-type="pmid">19342156</pub-id></element-citation></ref><ref id="ref311"><label>311</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chang</surname><given-names>J</given-names></name><name><surname>Hsu</surname><given-names>Y</given-names></name><name><surname>Kuo</surname><given-names>P</given-names></name><name><surname>Kuo</surname><given-names>Y</given-names></name><name><surname>Chiang</surname><given-names>L</given-names></name><name><surname>Lin</surname><given-names>C</given-names></name></person-group><article-title>Increase of Bax/Bcl-XL ratio and arrest of cell cycle by luteolin in immortalized human hepatoma cell line</article-title><source>Life Sci</source><year>2005</year><volume>76</volume><fpage>1883</fpage><lpage>93</lpage><pub-id pub-id-type="pmid">15698865</pub-id></element-citation></ref><ref id="ref312"><label>312</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yu</surname><given-names>J</given-names></name><name><surname>Liu</surname><given-names>H</given-names></name><name><surname>Lei</surname><given-names>J</given-names></name><name><surname>Tan</surname><given-names>W</given-names></name><name><surname>Hu</surname><given-names>X</given-names></name><name><surname>Zou</surname><given-names>G</given-names></name></person-group><article-title>Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents</article-title><source>Phytother Res</source><year>2007</year><volume>21</volume><fpage>817</fpage><lpage>22</lpage><pub-id pub-id-type="pmid">17674423</pub-id></element-citation></ref><ref id="ref313"><label>313</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhao</surname><given-names>Y</given-names></name><name><surname>Yang</surname><given-names>G</given-names></name><name><surname>Ren</surname><given-names>D</given-names></name><name><surname>Zhang</surname><given-names>X</given-names></name><name><surname>Yin</surname><given-names>Q</given-names></name><name><surname>Sun</surname><given-names>X</given-names></name></person-group><article-title>Luteolin suppresses growth and migration of human lung cancer cells</article-title><source>Mol Biol Rep</source><year>2011</year><volume>38</volume><fpage>1115</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">20589534</pub-id></element-citation></ref><ref id="ref314"><label>314</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>TT</given-names></name><name><surname>Wang</surname><given-names>SK</given-names></name><name><surname>Huang</surname><given-names>GL</given-names></name><name><surname>Sun</surname><given-names>GJ</given-names></name></person-group><article-title>Luteolin induced-growth inhibition and apoptosis of human esophageal squamous carcinoma cell line Eca109 cells <italic>in vitro</italic></article-title><source>Asian Pac J Cancer Prev</source><year>2012</year><volume>13</volume><fpage>5455</fpage><lpage>61</lpage><pub-id pub-id-type="pmid">23317200</pub-id></element-citation></ref><ref id="ref315"><label>315</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Harris</surname><given-names>DM</given-names></name><name><surname>Li</surname><given-names>L</given-names></name><name><surname>Chen</surname><given-names>M</given-names></name><name><surname>Lagunero</surname><given-names>FT</given-names></name><name><surname>Go</surname><given-names>VL</given-names></name><name><surname>Boros</surname><given-names>LG</given-names></name></person-group><article-title>Diverse mechanisms of growth inhibition by luteolin, resveratrol, and quercetin in MIA PaCa-2 cells: A comparative glucose tracer study with the fatty acid synthase inhibitor C75</article-title><source>Metabolomics</source><year>2012</year><volume>8</volume><fpage>201</fpage><lpage>10</lpage><pub-id pub-id-type="pmid">22754424</pub-id></element-citation></ref><ref id="ref316"><label>316</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Luo</surname><given-names>G</given-names></name><name><surname>Guan</surname><given-names>X</given-names></name><name><surname>Zhou</surname><given-names>L</given-names></name></person-group><article-title>Apoptotic effect of citrus fruit extract nobiletin on lung cancer cell line A549 <italic>in vitro</italic> and <italic>in vivo</italic></article-title><source>Cancer Biol Ther</source><year>2008</year><volume>7</volume><fpage>966</fpage><lpage>73</lpage><pub-id pub-id-type="pmid">18379194</pub-id></element-citation></ref><ref id="ref317"><label>317</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lust</surname><given-names>S</given-names></name><name><surname>Vanhoecke</surname><given-names>B</given-names></name><name><surname>Van Gele</surname><given-names>M</given-names></name><name><surname>Philippé</surname><given-names>J</given-names></name><name><surname>Bracke</surname><given-names>M</given-names></name><name><surname>Offner</surname><given-names>F</given-names></name></person-group><article-title>The flavonoid tangeretin activates the unfolded protein response and synergizes with imatinib in the erythroleukemia cell line K562</article-title><source>Mol Nutr Food Res</source><year>2010</year><volume>54</volume><fpage>823</fpage><lpage>32</lpage><pub-id pub-id-type="pmid">20077418</pub-id></element-citation></ref><ref id="ref318"><label>318</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huang</surname><given-names>ST</given-names></name><name><surname>Wang</surname><given-names>CY</given-names></name><name><surname>Yang</surname><given-names>RC</given-names></name><name><surname>Chu</surname><given-names>CJ</given-names></name><name><surname>Wu</surname><given-names>HT</given-names></name><name><surname>Pang</surname><given-names>JH</given-names></name></person-group><article-title>Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells</article-title><source>Phytomedicine</source><year>2010</year><volume>17</volume><fpage>47</fpage><lpage>54</lpage><pub-id pub-id-type="pmid">19577445</pub-id></element-citation></ref><ref id="ref319"><label>319</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yu</surname><given-names>JS</given-names></name><name><surname>Kim</surname><given-names>AK</given-names></name></person-group><article-title>Wogonin induces apoptosis by activation of ERK and p38 MAPKs signaling pathways and generation of reactive oxygen species in human breast cancer cells</article-title><source>Mol Cells</source><year>2011</year><volume>31</volume><fpage>327</fpage><lpage>35</lpage><pub-id pub-id-type="pmid">21448585</pub-id></element-citation></ref><ref id="ref320"><label>320</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huang</surname><given-names>KF</given-names></name><name><surname>Zhang</surname><given-names>GD</given-names></name><name><surname>Huang</surname><given-names>YQ</given-names></name><name><surname>Diao</surname><given-names>Y</given-names></name></person-group><article-title>Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway</article-title><source>Int Immunopharmacol</source><year>2012</year><volume>12</volume><fpage>334</fpage><lpage>41</lpage><pub-id pub-id-type="pmid">22182776</pub-id></element-citation></ref><ref id="ref321"><label>321</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>DH</given-names></name><name><surname>Kim</surname><given-names>C</given-names></name><name><surname>Zhang</surname><given-names>L</given-names></name><name><surname>Lee</surname><given-names>YJ</given-names></name></person-group><article-title>Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells</article-title><source>Biochem Pharmacol</source><year>2008</year><volume>75</volume><fpage>2020</fpage><lpage>33</lpage><pub-id pub-id-type="pmid">18377871</pub-id></element-citation></ref><ref id="ref322"><label>322</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>W</given-names></name><name><surname>Guo</surname><given-names>Q</given-names></name><name><surname>You</surname><given-names>Q</given-names></name><name><surname>Zhang</surname><given-names>K</given-names></name><name><surname>Yang</surname><given-names>Y</given-names></name><name><surname>Yu</surname><given-names>J</given-names></name><etal></etal></person-group><article-title>Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721</article-title><source>Anticancer Drugs</source><year>2006</year><volume>17</volume><fpage>797</fpage><lpage>805</lpage><pub-id pub-id-type="pmid">16926629</pub-id></element-citation></ref><ref id="ref323"><label>323</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cao</surname><given-names>XD</given-names></name><name><surname>Ding</surname><given-names>ZS</given-names></name><name><surname>Jiang</surname><given-names>FS</given-names></name><name><surname>Ding</surname><given-names>XH</given-names></name><name><surname>Chen</surname><given-names>JZ</given-names></name><name><surname>Chen</surname><given-names>SH</given-names></name><etal></etal></person-group><article-title>Antitumor constituents from the leaves of Carya cathayensis</article-title><source>Nat Prod Res</source><year>2012</year><volume>26</volume><fpage>2089</fpage><lpage>94</lpage><pub-id pub-id-type="pmid">22007794</pub-id></element-citation></ref><ref id="ref324"><label>324</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>DH</given-names></name><name><surname>Rhee</surname><given-names>JG</given-names></name><name><surname>Lee</surname><given-names>YJ</given-names></name></person-group><article-title>Reactive oxygen species up-regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin</article-title><source>Br J Pharmacol</source><year>2009</year><volume>157</volume><fpage>1189</fpage><lpage>202</lpage><pub-id pub-id-type="pmid">19438509</pub-id></element-citation></ref><ref id="ref325"><label>325</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shieh</surname><given-names>DE</given-names></name><name><surname>Cheng</surname><given-names>HY</given-names></name><name><surname>Yen</surname><given-names>MH</given-names></name><name><surname>Chiang</surname><given-names>LC</given-names></name><name><surname>Lin</surname><given-names>CC</given-names></name></person-group><article-title>Baicalin-induced apoptosis is mediated by Bcl-2-dependent, but not p53-dependent, pathway in human leukemia cell lines</article-title><source>Am J Chin Med</source><year>2006</year><volume>34</volume><fpage>245</fpage><lpage>61</lpage><pub-id pub-id-type="pmid">16552836</pub-id></element-citation></ref><ref id="ref326"><label>326</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mao</surname><given-names>W</given-names></name><name><surname>Chen</surname><given-names>X</given-names></name><name><surname>Yang</surname><given-names>T</given-names></name><name><surname>Yin</surname><given-names>Y</given-names></name><name><surname>Ge</surname><given-names>M</given-names></name><name><surname>Luo</surname><given-names>M</given-names></name><etal></etal></person-group><article-title>A rapid fluorescent screening method for cellular sensitivity to anti-cancer compound</article-title><source>Cytotechnology</source><year>2012</year><volume>64</volume><fpage>451</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">22476562</pub-id></element-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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