The Prospective Role of Plant Products in Radiotherapy of Cancer: A Current Overview
Identifieur interne : 001368 ( Pmc/Corpus ); précédent : 001367; suivant : 001369The Prospective Role of Plant Products in Radiotherapy of Cancer: A Current Overview
Auteurs : Banasri Hazra ; Subhalakshmi Ghosh ; Amit Kumar ; B. N. PandeySource :
- Frontiers in Pharmacology [ 1663-9812 ] ; 2012.
Abstract
Treatment of cancer often requires exposure to radiation, which has several limitations involving non-specific toxicity toward normal cells, reducing the efficacy of treatment. Efforts are going on to find chemical compounds which would effectively offer protection to the normal tissues after radiation exposure during radiotherapy of cancer. In this regard, plant-derived compounds might serve as “leads” to design ideal radioprotectors/radiosensitizers. This article reviews some of the recent findings on prospective medicinal plants, phytochemicals, and their analogs, based on both
Url:
DOI: 10.3389/fphar.2011.00094
PubMed: 22291649
PubMed Central: 3253585
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Prospective Role of Plant Products in Radiotherapy of Cancer: A Current Overview</title><author><name sortKey="Hazra, Banasri" sort="Hazra, Banasri" uniqKey="Hazra B" first="Banasri" last="Hazra">Banasri Hazra</name><affiliation><nlm:aff id="aff1"><institution>Department of Pharmaceutical Technology, Jadavpur University</institution><country>Kolkata, India</country></nlm:aff></affiliation></author><author><name sortKey="Ghosh, Subhalakshmi" sort="Ghosh, Subhalakshmi" uniqKey="Ghosh S" first="Subhalakshmi" last="Ghosh">Subhalakshmi Ghosh</name><affiliation><nlm:aff id="aff1"><institution>Department of Pharmaceutical Technology, Jadavpur University</institution><country>Kolkata, India</country></nlm:aff></affiliation></author><author><name sortKey="Kumar, Amit" sort="Kumar, Amit" uniqKey="Kumar A" first="Amit" last="Kumar">Amit Kumar</name><affiliation><nlm:aff id="aff2"><institution>Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre</institution><country>Mumbai, India</country></nlm:aff></affiliation></author><author><name sortKey="Pandey, B N" sort="Pandey, B N" uniqKey="Pandey B" first="B. N." last="Pandey">B. N. Pandey</name><affiliation><nlm:aff id="aff2"><institution>Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre</institution><country>Mumbai, India</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22291649</idno><idno type="pmc">3253585</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253585</idno><idno type="RBID">PMC:3253585</idno><idno type="doi">10.3389/fphar.2011.00094</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001368</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Prospective Role of Plant Products in Radiotherapy of Cancer: A Current Overview</title><author><name sortKey="Hazra, Banasri" sort="Hazra, Banasri" uniqKey="Hazra B" first="Banasri" last="Hazra">Banasri Hazra</name><affiliation><nlm:aff id="aff1"><institution>Department of Pharmaceutical Technology, Jadavpur University</institution><country>Kolkata, India</country></nlm:aff></affiliation></author><author><name sortKey="Ghosh, Subhalakshmi" sort="Ghosh, Subhalakshmi" uniqKey="Ghosh S" first="Subhalakshmi" last="Ghosh">Subhalakshmi Ghosh</name><affiliation><nlm:aff id="aff1"><institution>Department of Pharmaceutical Technology, Jadavpur University</institution><country>Kolkata, India</country></nlm:aff></affiliation></author><author><name sortKey="Kumar, Amit" sort="Kumar, Amit" uniqKey="Kumar A" first="Amit" last="Kumar">Amit Kumar</name><affiliation><nlm:aff id="aff2"><institution>Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre</institution><country>Mumbai, India</country></nlm:aff></affiliation></author><author><name sortKey="Pandey, B N" sort="Pandey, B N" uniqKey="Pandey B" first="B. N." last="Pandey">B. N. Pandey</name><affiliation><nlm:aff id="aff2"><institution>Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre</institution><country>Mumbai, India</country></nlm:aff></affiliation></author></analytic><series><title level="j">Frontiers in Pharmacology</title><idno type="eISSN">1663-9812</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Treatment of cancer often requires exposure to radiation, which has several limitations involving non-specific toxicity toward normal cells, reducing the efficacy of treatment. Efforts are going on to find chemical compounds which would effectively offer protection to the normal tissues after radiation exposure during radiotherapy of cancer. In this regard, plant-derived compounds might serve as “leads” to design ideal radioprotectors/radiosensitizers. This article reviews some of the recent findings on prospective medicinal plants, phytochemicals, and their analogs, based on both <italic>in vitro</italic> and <italic>in vivo</italic> tumor models especially focused with relevance to cancer radiotherapy. Also, pertinent discussion has been presented on the molecular mechanism of apoptotic death in relation to the oxidative stress in cancer cells induced by some of these plant samples and their active constituents.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adaramoye, O A" uniqKey="Adaramoye O">O. A. Adaramoye</name></author><author><name sortKey="Adedara, I A" uniqKey="Adedara I">I. A. Adedara</name></author><author><name sortKey="Popoola, B" uniqKey="Popoola B">B. Popoola</name></author><author><name sortKey="Farombi, E O" uniqKey="Farombi E">E. O. Farombi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adaramoye, O A" uniqKey="Adaramoye O">O. A. Adaramoye</name></author><author><name sortKey="Okiti, O O" uniqKey="Okiti O">O. O. Okiti</name></author><author><name sortKey="Farombi, E O" uniqKey="Farombi E">E. O. Farombi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adaramoye, O A" uniqKey="Adaramoye O">O. A. Adaramoye</name></author><author><name sortKey="Popoola, B O" uniqKey="Popoola B">B. O. Popoola</name></author><author><name sortKey="Farombi, E O" uniqKey="Farombi E">E. O. Farombi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adil, M D" uniqKey="Adil M">M. D. Adil</name></author><author><name sortKey="Kaiser, P" uniqKey="Kaiser P">P. Kaiser</name></author><author><name sortKey="Satti, N K" uniqKey="Satti N">N. K. Satti</name></author><author><name sortKey="Zargar, A M" uniqKey="Zargar A">A. M. Zargar</name></author><author><name sortKey="Vishwakarma, R A" uniqKey="Vishwakarma R">R. A. Vishwakarma</name></author><author><name sortKey="Tasduq, S A" uniqKey="Tasduq S">S. A. Tasduq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Afaq, F" uniqKey="Afaq F">F. Afaq</name></author><author><name sortKey="Khan, N" uniqKey="Khan N">N. Khan</name></author><author><name sortKey="Syed, D N" uniqKey="Syed D">D. N. Syed</name></author><author><name sortKey="Mukhtar, H" uniqKey="Mukhtar H">H. Mukhtar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Afaq, F" uniqKey="Afaq F">F. Afaq</name></author><author><name sortKey="Zaid, M A" uniqKey="Zaid M">M. A. Zaid</name></author><author><name sortKey="Khan, N" uniqKey="Khan N">N. Khan</name></author><author><name sortKey="Dreher, M" uniqKey="Dreher M">M. Dreher</name></author><author><name sortKey="Mukhtar, H" uniqKey="Mukhtar H">H. Mukhtar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akpolat, M" uniqKey="Akpolat M">M. Akpolat</name></author><author><name sortKey="Kanter, M" uniqKey="Kanter M">M. Kanter</name></author><author><name sortKey="Uzal, M C" uniqKey="Uzal M">M. C. Uzal</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Amorino, G P" uniqKey="Amorino G">G. P. Amorino</name></author><author><name sortKey="Mohr, P J" uniqKey="Mohr P">P. J. Mohr</name></author><author><name sortKey="Hercules, S K" uniqKey="Hercules S">S. K. Hercules</name></author><author><name sortKey="Pyo, H" uniqKey="Pyo H">H. Pyo</name></author><author><name sortKey="Choy, H" uniqKey="Choy H">H. Choy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arasada, B L" uniqKey="Arasada B">B. L. Arasada</name></author><author><name sortKey="Bommareddy, A" uniqKey="Bommareddy A">A. Bommareddy</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Bremmon, K" uniqKey="Bremmon K">K. Bremmon</name></author><author><name sortKey="Dwivedi, C" uniqKey="Dwivedi C">C. Dwivedi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aravindan, N" uniqKey="Aravindan N">N. Aravindan</name></author><author><name sortKey="Veeraraghavan, J" uniqKey="Veeraraghavan J">J. Veeraraghavan</name></author><author><name sortKey="Madhusoodhanan, R" uniqKey="Madhusoodhanan R">R. Madhusoodhanan</name></author><author><name sortKey="Herman, T S" uniqKey="Herman T">T. S. Herman</name></author><author><name sortKey="Natarajan, M" uniqKey="Natarajan M">M. Natarajan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arora, R" uniqKey="Arora R">R. Arora</name></author><author><name sortKey="Gupta, D" uniqKey="Gupta D">D. Gupta</name></author><author><name sortKey="Chawla, R" uniqKey="Chawla R">R. Chawla</name></author><author><name sortKey="Sagar, R" uniqKey="Sagar R">R. Sagar</name></author><author><name sortKey="Sharma, A" uniqKey="Sharma A">A. Sharma</name></author><author><name sortKey="Kumar, R" uniqKey="Kumar R">R. Kumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bache, M" uniqKey="Bache M">M. Bache</name></author><author><name sortKey="Zschornak, M P" uniqKey="Zschornak M">M. P. Zschornak</name></author><author><name sortKey="Passin, S" uniqKey="Passin S">S. Passin</name></author><author><name sortKey="Kessler, J" uniqKey="Kessler J">J. Kessler</name></author><author><name sortKey="Wichmann, H" uniqKey="Wichmann H">H. Wichmann</name></author><author><name sortKey="Kappler, M" uniqKey="Kappler M">M. Kappler</name></author><author><name sortKey="Paschke, R" uniqKey="Paschke R">R. Paschke</name></author><author><name sortKey="Kaluderovic, G N" uniqKey="Kaluderovic G">G. N. Kaluderovic</name></author><author><name sortKey="Kommera, H" uniqKey="Kommera H">H. Kommera</name></author><author><name sortKey="Taubert, H" uniqKey="Taubert H">H. Taubert</name></author><author><name sortKey="Vordermark, D" uniqKey="Vordermark D">D. Vordermark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bae, J Y" uniqKey="Bae J">J. Y. Bae</name></author><author><name sortKey="Choi, J S" uniqKey="Choi J">J. S. Choi</name></author><author><name sortKey="Kang, S W" uniqKey="Kang S">S. W. Kang</name></author><author><name sortKey="Lee, Y J" uniqKey="Lee Y">Y. J. Lee</name></author><author><name sortKey="Park, J" uniqKey="Park J">J. Park</name></author><author><name sortKey="Kang, Y H" uniqKey="Kang Y">Y. H. Kang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bakuridze, A D" uniqKey="Bakuridze A">A. D. Bakuridze</name></author><author><name sortKey="Nikolaev, S M" uniqKey="Nikolaev S">S. M. Nikolaev</name></author><author><name sortKey="Berashvili, D T" uniqKey="Berashvili D">D. T. Berashvili</name></author><author><name sortKey="Bakuridze, K A" uniqKey="Bakuridze K">K. A. Bakuridze</name></author><author><name sortKey="Tsomaia, I V" uniqKey="Tsomaia I">I. V. Tsomaia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baliga, M S" uniqKey="Baliga M">M. S. Baliga</name></author><author><name sortKey="Bhat, H P" uniqKey="Bhat H">H. P. Bhat</name></author><author><name sortKey="Pereira, M M" uniqKey="Pereira M">M. M. Pereira</name></author><author><name sortKey="Mathias, N" uniqKey="Mathias N">N. Mathias</name></author><author><name sortKey="Venkatesh, P" uniqKey="Venkatesh P">P. Venkatesh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baliga, M S" uniqKey="Baliga M">M. S. Baliga</name></author><author><name sortKey="Rao, S" uniqKey="Rao S">S. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benhar, M" uniqKey="Benhar M">M. Benhar</name></author><author><name sortKey="Dalyot, I" uniqKey="Dalyot I">I. Dalyot</name></author><author><name sortKey="Engelberg, D" uniqKey="Engelberg D">D. Engelberg</name></author><author><name sortKey="Levitzki, A" uniqKey="Levitzki A">A. Levitzki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bensadoun, R J" uniqKey="Bensadoun R">R. J. Bensadoun</name></author><author><name sortKey="Schubert, M M" uniqKey="Schubert M">M. M. Schubert</name></author><author><name sortKey="Lalla, R V" uniqKey="Lalla R">R. V. Lalla</name></author><author><name sortKey="Keefe, D" uniqKey="Keefe D">D. Keefe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bhosle, S M" uniqKey="Bhosle S">S. M. Bhosle</name></author><author><name sortKey="Ahire, V R" uniqKey="Ahire V">V. R. Ahire</name></author><author><name sortKey="Henry, M S" uniqKey="Henry M">M. S. Henry</name></author><author><name sortKey="Thakur, V S" uniqKey="Thakur V">V. S. Thakur</name></author><author><name sortKey="Huilgol, N G" uniqKey="Huilgol N">N. G. Huilgol</name></author><author><name sortKey="Mishra, K P" uniqKey="Mishra K">K. P. Mishra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bray, F" uniqKey="Bray F">F. Bray</name></author><author><name sortKey="Moller, B" uniqKey="Moller B">B. Moller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burris, H A" uniqKey="Burris H">H. A. Burris</name></author><author><name sortKey="Hurtig, J" uniqKey="Hurtig J">J. Hurtig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cao, G" uniqKey="Cao G">G. Cao</name></author><author><name sortKey="Chen, M" uniqKey="Chen M">M. Chen</name></author><author><name sortKey="Song, Q" uniqKey="Song Q">Q. Song</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Xie, L" uniqKey="Xie L">L. Xie</name></author><author><name sortKey="Han, Y" uniqKey="Han Y">Y. Han</name></author><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z. Liu</name></author><author><name sortKey="Ji, Y" uniqKey="Ji Y">Y. Ji</name></author><author><name sortKey="Jiang, Q" uniqKey="Jiang Q">Q. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carsten, R E" uniqKey="Carsten R">R. E. Carsten</name></author><author><name sortKey="Bachand, A M" uniqKey="Bachand A">A. M. Bachand</name></author><author><name sortKey="Bailey, S M" uniqKey="Bailey S">S. M. Bailey</name></author><author><name sortKey="Ullrich, R L" uniqKey="Ullrich R">R. L. Ullrich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, M L" uniqKey="Chen M">M. L. Chen</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author><author><name sortKey="Xiao, W R" uniqKey="Xiao W">W. R. Xiao</name></author><author><name sortKey="Sun, L" uniqKey="Sun L">L. Sun</name></author><author><name sortKey="Tang, H" uniqKey="Tang H">H. Tang</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author><author><name sortKey="Wu, L Y" uniqKey="Wu L">L. Y. Wu</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author><author><name sortKey="Xie, H F" uniqKey="Xie H">H. F. Xie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chilampalli, S" uniqKey="Chilampalli S">S. Chilampalli</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Fahmy, H" uniqKey="Fahmy H">H. Fahmy</name></author><author><name sortKey="Kaushik, R S" uniqKey="Kaushik R">R. S. Kaushik</name></author><author><name sortKey="Zeman, D" uniqKey="Zeman D">D. Zeman</name></author><author><name sortKey="Hildreth, M B" uniqKey="Hildreth M">M. B. Hildreth</name></author><author><name sortKey="Dwivedi, C" uniqKey="Dwivedi C">C. Dwivedi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choy, H" uniqKey="Choy H">H. Choy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cimino, F" uniqKey="Cimino F">F. Cimino</name></author><author><name sortKey="Cristani, M" uniqKey="Cristani M">M. Cristani</name></author><author><name sortKey="Saija, A" uniqKey="Saija A">A. Saija</name></author><author><name sortKey="Bonina, F P" uniqKey="Bonina F">F. P. Bonina</name></author><author><name sortKey="Virgili, F" uniqKey="Virgili F">F. Virgili</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Curry, H A" uniqKey="Curry H">H. A. Curry</name></author><author><name sortKey="Curran, W J" uniqKey="Curran W">W. J. Curran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Da Silva, V V" uniqKey="Da Silva V">V. V. da Silva</name></author><author><name sortKey="Ropke, C D" uniqKey="Ropke C">C. D. Ropke</name></author><author><name sortKey="Miranda, D V" uniqKey="Miranda D">D. V. Miranda</name></author><author><name sortKey="De Almeida, R L" uniqKey="De Almeida R">R. L. de Almeida</name></author><author><name sortKey="Sawada, T C" uniqKey="Sawada T">T. C. Sawada</name></author><author><name sortKey="Rivelli, D P" uniqKey="Rivelli D">D. P. Rivelli</name></author><author><name sortKey="Barros, S B" uniqKey="Barros S">S. B. Barros</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dange, P" uniqKey="Dange P">P. Dange</name></author><author><name sortKey="Sarma, H" uniqKey="Sarma H">H. Sarma</name></author><author><name sortKey="Pandey, B N" uniqKey="Pandey B">B. N. Pandey</name></author><author><name sortKey="Mishra, K P" uniqKey="Mishra K">K. P. Mishra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dest, V M" uniqKey="Dest V">V. M. Dest</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dong, G Z" uniqKey="Dong G">G. Z. Dong</name></author><author><name sortKey="Oh, E T" uniqKey="Oh E">E. T. Oh</name></author><author><name sortKey="Lee, H" uniqKey="Lee H">H. Lee</name></author><author><name sortKey="Park, M T" uniqKey="Park M">M. T. Park</name></author><author><name sortKey="Song, C W" uniqKey="Song C">C. W. Song</name></author><author><name sortKey="Park, H J" uniqKey="Park H">H. J. Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dong, Y" uniqKey="Dong Y">Y. Dong</name></author><author><name sortKey="Bey, E A" uniqKey="Bey E">E. A. Bey</name></author><author><name sortKey="Li, L S" uniqKey="Li L">L. S. Li</name></author><author><name sortKey="Kabbani, W" uniqKey="Kabbani W">W. Kabbani</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J. Yan</name></author><author><name sortKey="Xie, X J" uniqKey="Xie X">X. J. Xie</name></author><author><name sortKey="Hsieh, J T" uniqKey="Hsieh J">J. T. Hsieh</name></author><author><name sortKey="Gao, J" uniqKey="Gao J">J. Gao</name></author><author><name sortKey="Boothman, D A" uniqKey="Boothman D">D. A. Boothman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Droge, W" uniqKey="Droge W">W. Droge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dujic, J" uniqKey="Dujic J">J. Dujic</name></author><author><name sortKey="Kippenberger, S" uniqKey="Kippenberger S">S. Kippenberger</name></author><author><name sortKey="Ramirez Bosca, A" uniqKey="Ramirez Bosca A">A. Ramirez-Bosca</name></author><author><name sortKey="Diaz Alperi, J" uniqKey="Diaz Alperi J">J. Diaz-Alperi</name></author><author><name sortKey="Bereiter Hahn, J" uniqKey="Bereiter Hahn J">J. Bereiter-Hahn</name></author><author><name sortKey="Kaufmann, R" uniqKey="Kaufmann R">R. Kaufmann</name></author><author><name sortKey="Bernd, A" uniqKey="Bernd A">A. Bernd</name></author><author><name sortKey="Hofmann, M" uniqKey="Hofmann M">M. Hofmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eder Czembirek, C" uniqKey="Eder Czembirek C">C. Eder-Czembirek</name></author><author><name sortKey="Erovic, B M" uniqKey="Erovic B">B. M. Erovic</name></author><author><name sortKey="Czembirek, C" uniqKey="Czembirek C">C. Czembirek</name></author><author><name sortKey="Brunner, M" uniqKey="Brunner M">M. Brunner</name></author><author><name sortKey="Selzer, E" uniqKey="Selzer E">E. Selzer</name></author><author><name sortKey="Potter, R" uniqKey="Potter R">R. Pötter</name></author><author><name sortKey="Thurnher, D" uniqKey="Thurnher D">D. Thurnher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Edwards, A" uniqKey="Edwards A">A. Edwards</name></author><author><name sortKey="Gladstone, M" uniqKey="Gladstone M">M. Gladstone</name></author><author><name sortKey="Yoon, P" uniqKey="Yoon P">P. Yoon</name></author><author><name sortKey="Raben, D" uniqKey="Raben D">D. Raben</name></author><author><name sortKey="Frederick, B" uniqKey="Frederick B">B. Frederick</name></author><author><name sortKey="Su, T T" uniqKey="Su T">T. T. Su</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elledge, R M" uniqKey="Elledge R">R. M. Elledge</name></author><author><name sortKey="Lee, W H" uniqKey="Lee W">W. H. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fu, H" uniqKey="Fu H">H. Fu</name></author><author><name sortKey="Lin, M" uniqKey="Lin M">M. Lin</name></author><author><name sortKey="Katsumura, Y" uniqKey="Katsumura Y">Y. Katsumura</name></author><author><name sortKey="Yokoya, A" uniqKey="Yokoya A">A. Yokoya</name></author><author><name sortKey="Hata, K" uniqKey="Hata K">K. Hata</name></author><author><name sortKey="Muroya, Y" uniqKey="Muroya Y">Y. Muroya</name></author><author><name sortKey="Fujii, K" uniqKey="Fujii K">K. Fujii</name></author><author><name sortKey="Shikazono, N" uniqKey="Shikazono N">N. Shikazono</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garg, A K" uniqKey="Garg A">A. K. Garg</name></author><author><name sortKey="Buchholz, T A" uniqKey="Buchholz T">T. A. Buchholz</name></author><author><name sortKey="Aggarwal, B B" uniqKey="Aggarwal B">B. B. Aggarwal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Girdhani, S" uniqKey="Girdhani S">S. Girdhani</name></author><author><name sortKey="Bhosle, S M" uniqKey="Bhosle S">S. M. Bhosle</name></author><author><name sortKey="Thulasidas, S A" uniqKey="Thulasidas S">S. A. Thulasidas</name></author><author><name sortKey="Kumar, A" uniqKey="Kumar A">A. Kumar</name></author><author><name sortKey="Mishra, K P" uniqKey="Mishra K">K. P. Mishra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grdina, D J" uniqKey="Grdina D">D. J. Grdina</name></author><author><name sortKey="Murley, J S" uniqKey="Murley J">J. S. Murley</name></author><author><name sortKey="Kataoka, Y" uniqKey="Kataoka Y">Y. Kataoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gu, M" uniqKey="Gu M">M. Gu</name></author><author><name sortKey="Singh, R P" uniqKey="Singh R">R. P. Singh</name></author><author><name sortKey="Dhanalakshmi, S" uniqKey="Dhanalakshmi S">S. Dhanalakshmi</name></author><author><name sortKey="Mohan, S" uniqKey="Mohan S">S. Mohan</name></author><author><name sortKey="Agarwal, R" uniqKey="Agarwal R">R. Agarwal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gupta, U" uniqKey="Gupta U">U. Gupta</name></author><author><name sortKey="Jahan, S" uniqKey="Jahan S">S. Jahan</name></author><author><name sortKey="Chaudhary, R" uniqKey="Chaudhary R">R. Chaudhary</name></author><author><name sortKey="Goyal, P K" uniqKey="Goyal P">P. K. Goyal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guruvayoorappan, C" uniqKey="Guruvayoorappan C">C. Guruvayoorappan</name></author><author><name sortKey="Kuttan, G" uniqKey="Kuttan G">G. Kuttan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gutheil, W G" uniqKey="Gutheil W">W. G. Gutheil</name></author><author><name sortKey="Reed, G" uniqKey="Reed G">G. Reed</name></author><author><name sortKey="Ray, A" uniqKey="Ray A">A. Ray</name></author><author><name sortKey="Dhar, A" uniqKey="Dhar A">A. Dhar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halliwell, B" uniqKey="Halliwell B">B. Halliwell</name></author><author><name sortKey="Gutteridge, J M C" uniqKey="Gutteridge J">J. M. C. Gutteridge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, G" uniqKey="Han G">G. Han</name></author><author><name sortKey="Zhou, Y F" uniqKey="Zhou Y">Y. F. Zhou</name></author><author><name sortKey="Zhang, M S" uniqKey="Zhang M">M. S. Zhang</name></author><author><name sortKey="Cao, Z" uniqKey="Cao Z">Z. Cao</name></author><author><name sortKey="Xie, C H" uniqKey="Xie C">C. H. Xie</name></author><author><name sortKey="Zhou, F X" uniqKey="Zhou F">F. X. Zhou</name></author><author><name sortKey="Peng, M" uniqKey="Peng M">M. Peng</name></author><author><name sortKey="Zhang, W J" uniqKey="Zhang W">W. J. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hara, T" uniqKey="Hara T">T. Hara</name></author><author><name sortKey="Omura Minamisawa, M" uniqKey="Omura Minamisawa M">M. Omura-Minamisawa</name></author><author><name sortKey="Kang, Y" uniqKey="Kang Y">Y. Kang</name></author><author><name sortKey="Cheng, C" uniqKey="Cheng C">C. Cheng</name></author><author><name sortKey="Inoue, T" uniqKey="Inoue T">T. Inoue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harikumar, K B" uniqKey="Harikumar K">K. B. Harikumar</name></author><author><name sortKey="Kuttan, R" uniqKey="Kuttan R">R. Kuttan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hasselbalch, B" uniqKey="Hasselbalch B">B. Hasselbalch</name></author><author><name sortKey="Lassen, U" uniqKey="Lassen U">U. Lassen</name></author><author><name sortKey="Hansen, S" uniqKey="Hansen S">S. Hansen</name></author><author><name sortKey="Holmberg, M" uniqKey="Holmberg M">M. Holmberg</name></author><author><name sortKey="S Rensen, M" uniqKey="S Rensen M">M. Sørensen</name></author><author><name sortKey="Kosteljanetz, M" uniqKey="Kosteljanetz M">M. Kosteljanetz</name></author><author><name sortKey="Broholm, H" uniqKey="Broholm H">H. Broholm</name></author><author><name sortKey="Stockhausen, M T" uniqKey="Stockhausen M">M. T. Stockhausen</name></author><author><name sortKey="Poulsen, H S" uniqKey="Poulsen H">H. S. Poulsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hazra, B" uniqKey="Hazra B">B. Hazra</name></author><author><name sortKey="Das, S M" uniqKey="Das S">S. M. Das</name></author><author><name sortKey="Kumar, B" uniqKey="Kumar B">B. Kumar</name></author><author><name sortKey="Basu, S" uniqKey="Basu S">S. Basu</name></author><author><name sortKey="Das, K" uniqKey="Das K">K. Das</name></author><author><name sortKey="Pandey, B N" uniqKey="Pandey B">B. N. Pandey</name></author><author><name sortKey="Mishra, K P" uniqKey="Mishra K">K. P. Mishra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hiro, J" uniqKey="Hiro J">J. Hiro</name></author><author><name sortKey="Inoue, Y" uniqKey="Inoue Y">Y. Inoue</name></author><author><name sortKey="Toiyama, Y" uniqKey="Toiyama Y">Y. Toiyama</name></author><author><name sortKey="Yoshiyama, S" uniqKey="Yoshiyama S">S. Yoshiyama</name></author><author><name sortKey="Tanaka, K" uniqKey="Tanaka K">K. Tanaka</name></author><author><name sortKey="Mohri, Y" uniqKey="Mohri Y">Y. Mohri</name></author><author><name sortKey="Miki, C" uniqKey="Miki C">C. Miki</name></author><author><name sortKey="Kusunoki, M" uniqKey="Kusunoki M">M. Kusunoki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hu, J" uniqKey="Hu J">J. Hu</name></author><author><name sortKey="Chen, L J" uniqKey="Chen L">L. J. Chen</name></author><author><name sortKey="Liu, L" uniqKey="Liu L">L. Liu</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author><author><name sortKey="Chen, P L" uniqKey="Chen P">P. L. Chen</name></author><author><name sortKey="Yang, G" uniqKey="Yang G">G. Yang</name></author><author><name sortKey="Hou, W L" uniqKey="Hou W">W. L. Hou</name></author><author><name sortKey="Tang, M H" uniqKey="Tang M">M. H. Tang</name></author><author><name sortKey="Zhang, F" uniqKey="Zhang F">F. Zhang</name></author><author><name sortKey="Wang, X H" uniqKey="Wang X">X. H. Wang</name></author><author><name sortKey="Zhao, X" uniqKey="Zhao X">X. Zhao</name></author><author><name sortKey="Wei, Y Q" uniqKey="Wei Y">Y. Q. Wei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C. Huang</name></author><author><name sortKey="Zhang, D" uniqKey="Zhang D">D. Zhang</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author><author><name sortKey="Tong, Q" uniqKey="Tong Q">Q. Tong</name></author><author><name sortKey="Stoner, G D" uniqKey="Stoner G">G. D. Stoner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, J C" uniqKey="Huang J">J. C. Huang</name></author><author><name sortKey="Zhao, P C" uniqKey="Zhao P">P. C. Zhao</name></author><author><name sortKey="Zhang, H Z" uniqKey="Zhang H">H. Z. Zhang</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Illum, H" uniqKey="Illum H">H. Illum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jagetia, G C" uniqKey="Jagetia G">G. C. Jagetia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jagetia, G C" uniqKey="Jagetia G">G. C. Jagetia</name></author><author><name sortKey="Rajanikant, G K" uniqKey="Rajanikant G">G. K. Rajanikant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jagetia, G C" uniqKey="Jagetia G">G. C. Jagetia</name></author><author><name sortKey="Shetty, P C" uniqKey="Shetty P">P. C. Shetty</name></author><author><name sortKey="Vidyasagar, M S" uniqKey="Vidyasagar M">M. S. Vidyasagar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jagetia, G C" uniqKey="Jagetia G">G. C. Jagetia</name></author><author><name sortKey="Venkatesha, V A" uniqKey="Venkatesha V">V. A. Venkatesha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jahan, S" uniqKey="Jahan S">S. Jahan</name></author><author><name sortKey="Goyal, P K" uniqKey="Goyal P">P. K. Goyal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeong, H C" uniqKey="Jeong H">H. C. Jeong</name></author><author><name sortKey="Lee, S Y" uniqKey="Lee S">S. Y. Lee</name></author><author><name sortKey="Lee, S Y" uniqKey="Lee S">S. Y. Lee</name></author><author><name sortKey="Kim, J H" uniqKey="Kim J">J. H. Kim</name></author><author><name sortKey="Shin, C" uniqKey="Shin C">C. Shin</name></author><author><name sortKey="Shim, J J" uniqKey="Shim J">J. J. Shim</name></author><author><name sortKey="In, K H" uniqKey="In K">K. H. In</name></author><author><name sortKey="Kang, K H" uniqKey="Kang K">K. H. Kang</name></author><author><name sortKey="Yoo, S H" uniqKey="Yoo S">S. H. Yoo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeong, S Y" uniqKey="Jeong S">S. Y. Jeong</name></author><author><name sortKey="Park, S J" uniqKey="Park S">S. J. Park</name></author><author><name sortKey="Yoon, S M" uniqKey="Yoon S">S. M. Yoon</name></author><author><name sortKey="Jung, J" uniqKey="Jung J">J. Jung</name></author><author><name sortKey="Woo, H N" uniqKey="Woo H">H. N. Woo</name></author><author><name sortKey="Yi, S L" uniqKey="Yi S">S. L. Yi</name></author><author><name sortKey="Song, S Y" uniqKey="Song S">S. Y. Song</name></author><author><name sortKey="Park, H J" uniqKey="Park H">H. J. Park</name></author><author><name sortKey="Kim, C" uniqKey="Kim C">C. Kim</name></author><author><name sortKey="Lee, J S" uniqKey="Lee J">J. S. Lee</name></author><author><name sortKey="Lee, J S" uniqKey="Lee J">J. S. Lee</name></author><author><name sortKey="Choi, E K" uniqKey="Choi E">E. K. Choi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, S L" uniqKey="Jin S">S. L. Jin</name></author><author><name sortKey="Zhou, B R" uniqKey="Zhou B">B. R. Zhou</name></author><author><name sortKey="Luo, D" uniqKey="Luo D">D. Luo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jindal, A" uniqKey="Jindal A">A. Jindal</name></author><author><name sortKey="Agrawal, A" uniqKey="Agrawal A">A. Agrawal</name></author><author><name sortKey="Goyal, P K" uniqKey="Goyal P">P. K. Goyal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jindal, A" uniqKey="Jindal A">A. Jindal</name></author><author><name sortKey="Soyal, D" uniqKey="Soyal D">D. Soyal</name></author><author><name sortKey="Sharma, A" uniqKey="Sharma A">A. Sharma</name></author><author><name sortKey="Goyal, P K" uniqKey="Goyal P">P. K. Goyal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, G E" uniqKey="Johnson G">G. E. Johnson</name></author><author><name sortKey="Ivanov, V N" uniqKey="Ivanov V">V. N. Ivanov</name></author><author><name sortKey="Hei, T K" uniqKey="Hei T">T. K. Hei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kalthur, G" uniqKey="Kalthur G">G. Kalthur</name></author><author><name sortKey="Pathirissery, U D" uniqKey="Pathirissery U">U. D. Pathirissery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kamata, H" uniqKey="Kamata H">H. Kamata</name></author><author><name sortKey="Shibukawa, Y" uniqKey="Shibukawa Y">Y. Shibukawa</name></author><author><name sortKey="Oka, S I" uniqKey="Oka S">S. I. Oka</name></author><author><name sortKey="Hirata, H" uniqKey="Hirata H">H. Hirata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kao, C L" uniqKey="Kao C">C. L. Kao</name></author><author><name sortKey="Huang, P I" uniqKey="Huang P">P. I. Huang</name></author><author><name sortKey="Tsai, P H" uniqKey="Tsai P">P. H. Tsai</name></author><author><name sortKey="Tsai, M L" uniqKey="Tsai M">M. L. Tsai</name></author><author><name sortKey="Lo, J F" uniqKey="Lo J">J. F. Lo</name></author><author><name sortKey="Lee, Y Y" uniqKey="Lee Y">Y. Y. Lee</name></author><author><name sortKey="Chen, Y J" uniqKey="Chen Y">Y. J. Chen</name></author><author><name sortKey="Chen, Y W" uniqKey="Chen Y">Y. W. Chen</name></author><author><name sortKey="Chiou, S H" uniqKey="Chiou S">S. H. Chiou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katiyar, S K" uniqKey="Katiyar S">S. K. Katiyar</name></author><author><name sortKey="Afaq, F" uniqKey="Afaq F">F. Afaq</name></author><author><name sortKey="Azizuddin, K" uniqKey="Azizuddin K">K. Azizuddin</name></author><author><name sortKey="Mukhtar, H" uniqKey="Mukhtar H">H. Mukhtar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katiyar, S K" uniqKey="Katiyar S">S. K. Katiyar</name></author><author><name sortKey="Mantena, S K" uniqKey="Mantena S">S. K. Mantena</name></author><author><name sortKey="Meeran, S M" uniqKey="Meeran S">S. M. Meeran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katiyar, S K" uniqKey="Katiyar S">S. K. Katiyar</name></author><author><name sortKey="Meleth, S" uniqKey="Meleth S">S. Meleth</name></author><author><name sortKey="Sharma, S D" uniqKey="Sharma S">S. D. Sharma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kienle, G S" uniqKey="Kienle G">G. S. Kienle</name></author><author><name sortKey="Kiene, H" uniqKey="Kiene H">H. Kiene</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kimura, Y" uniqKey="Kimura Y">Y. Kimura</name></author><author><name sortKey="Sumiyoshi, M" uniqKey="Sumiyoshi M">M. Sumiyoshi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kinsella, T J" uniqKey="Kinsella T">T. J. Kinsella</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klautke, G" uniqKey="Klautke G">G. Klautke</name></author><author><name sortKey="Kuchenmeister, U" uniqKey="Kuchenmeister U">U. Küchenmeister</name></author><author><name sortKey="Foitzik, T" uniqKey="Foitzik T">T. Foitzik</name></author><author><name sortKey="Ludwig, K" uniqKey="Ludwig K">K. Ludwig</name></author><author><name sortKey="Prall, F" uniqKey="Prall F">F. Prall</name></author><author><name sortKey="Klar, E" uniqKey="Klar E">E. Klar</name></author><author><name sortKey="Fietkau, R" uniqKey="Fietkau R">R. Fietkau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kondo, S" uniqKey="Kondo S">S. Kondo</name></author><author><name sortKey="Toyokuni, S" uniqKey="Toyokuni S">S. Toyokuni</name></author><author><name sortKey="Iwasa, Y" uniqKey="Iwasa Y">Y. Iwasa</name></author><author><name sortKey="Tanaka, T" uniqKey="Tanaka T">T. Tanaka</name></author><author><name sortKey="Onodera, H" uniqKey="Onodera H">H. Onodera</name></author><author><name sortKey="Hiai, H" uniqKey="Hiai H">H. Hiai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, B" uniqKey="Kumar B">B. Kumar</name></author><author><name sortKey="Joshi, J" uniqKey="Joshi J">J. Joshi</name></author><author><name sortKey="Kumar, A" uniqKey="Kumar A">A. Kumar</name></author><author><name sortKey="Pandey, B N" uniqKey="Pandey B">B. N. Pandey</name></author><author><name sortKey="Hazra, B" uniqKey="Hazra B">B. Hazra</name></author><author><name sortKey="Mishra, K P" uniqKey="Mishra K">K. P. Mishra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, B" uniqKey="Kumar B">B. Kumar</name></author><author><name sortKey="Kumar, A" uniqKey="Kumar A">A. Kumar</name></author><author><name sortKey="Pandey, B N" uniqKey="Pandey B">B. N. Pandey</name></author><author><name sortKey="Hazra, B" uniqKey="Hazra B">B. Hazra</name></author><author><name sortKey="Mishra, K P" uniqKey="Mishra K">K. P. Mishra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kundu, J K" uniqKey="Kundu J">J. K. Kundu</name></author><author><name sortKey="Chang, E J" uniqKey="Chang E">E. J. Chang</name></author><author><name sortKey="Fujii, H" uniqKey="Fujii H">H. Fujii</name></author><author><name sortKey="Sun, B" uniqKey="Sun B">B. Sun</name></author><author><name sortKey="Surh, Y J" uniqKey="Surh Y">Y. J. Surh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Langer, C J" uniqKey="Langer C">C. J. Langer</name></author><author><name sortKey="Somer, R" uniqKey="Somer R">R. Somer</name></author><author><name sortKey="Litwin, S" uniqKey="Litwin S">S. Litwin</name></author><author><name sortKey="Feigenberg, S" uniqKey="Feigenberg S">S. Feigenberg</name></author><author><name sortKey="Movsas, B" uniqKey="Movsas B">B. Movsas</name></author><author><name sortKey="Maiale, C" uniqKey="Maiale C">C. Maiale</name></author><author><name sortKey="Sherman, E" uniqKey="Sherman E">E. Sherman</name></author><author><name sortKey="Millenson, M" uniqKey="Millenson M">M. Millenson</name></author><author><name sortKey="Nicoloau, N" uniqKey="Nicoloau N">N. Nicoloau</name></author><author><name sortKey="Huang, C" uniqKey="Huang C">C. Huang</name></author><author><name sortKey="Treat, J" uniqKey="Treat J">J. Treat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, D E" uniqKey="Lee D">D. E. Lee</name></author><author><name sortKey="Lee, K W" uniqKey="Lee K">K. W. Lee</name></author><author><name sortKey="Byun, S" uniqKey="Byun S">S. Byun</name></author><author><name sortKey="Jung, S K" uniqKey="Jung S">S. K. Jung</name></author><author><name sortKey="Song, N" uniqKey="Song N">N. Song</name></author><author><name sortKey="Lim, S H" uniqKey="Lim S">S. H. Lim</name></author><author><name sortKey="Heo, Y S" uniqKey="Heo Y">Y. S. Heo</name></author><author><name sortKey="Kim, J E" uniqKey="Kim J">J. E. Kim</name></author><author><name sortKey="Kang, N J" uniqKey="Kang N">N. J. Kang</name></author><author><name sortKey="Kim, B Y" uniqKey="Kim B">B. Y. Kim</name></author><author><name sortKey="Bowden, G T" uniqKey="Bowden G">G. T. Bowden</name></author><author><name sortKey="Bode, A M" uniqKey="Bode A">A. M. Bode</name></author><author><name sortKey="Lee, H J" uniqKey="Lee H">H. J. Lee</name></author><author><name sortKey="Dong, Z" uniqKey="Dong Z">Z. Dong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, H J" uniqKey="Lee H">H. J. Lee</name></author><author><name sortKey="Kim, J S" uniqKey="Kim J">J. S. Kim</name></author><author><name sortKey="Moon, C" uniqKey="Moon C">C. Moon</name></author><author><name sortKey="Kim, J C" uniqKey="Kim J">J. C. Kim</name></author><author><name sortKey="Lee, Y S" uniqKey="Lee Y">Y. S. Lee</name></author><author><name sortKey="Jang, J S" uniqKey="Jang J">J. S. Jang</name></author><author><name sortKey="Jo, S K" uniqKey="Jo S">S. K. Jo</name></author><author><name sortKey="Kim, S H" uniqKey="Kim S">S. H. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, T K" uniqKey="Lee T">T. K. Lee</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name></author><author><name sortKey="O Rien, K F" uniqKey="O Rien K">K. F. O’Brien</name></author><author><name sortKey="Johnke, R M" uniqKey="Johnke R">R. M. Johnke</name></author><author><name sortKey="Wang, T" uniqKey="Wang T">T. Wang</name></author><author><name sortKey="Allison, R R" uniqKey="Allison R">R. R. Allison</name></author><author><name sortKey="Diaz, A L" uniqKey="Diaz A">A. L. Diaz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, H J" uniqKey="Lee H">H. J. Lee</name></author><author><name sortKey="Kim, J S" uniqKey="Kim J">J. S. Kim</name></author><author><name sortKey="Song, M S" uniqKey="Song M">M. S. Song</name></author><author><name sortKey="Seo, H S" uniqKey="Seo H">H. S. Seo</name></author><author><name sortKey="Moon, C" uniqKey="Moon C">C. Moon</name></author><author><name sortKey="Kim, J C" uniqKey="Kim J">J. C. Kim</name></author><author><name sortKey="Jo, S K" uniqKey="Jo S">S. K. Jo</name></author><author><name sortKey="Jang, J S" uniqKey="Jang J">J. S. Jang</name></author><author><name sortKey="Kim, S H" uniqKey="Kim S">S. H. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, S M" uniqKey="Lee S">S. M. Lee</name></author><author><name sortKey="Li, M L" uniqKey="Li M">M. L. Li</name></author><author><name sortKey="Tse, Y C" uniqKey="Tse Y">Y. C. Tse</name></author><author><name sortKey="Leung, S C" uniqKey="Leung S">S. C. Leung</name></author><author><name sortKey="Lee, M M" uniqKey="Lee M">M. M. Lee</name></author><author><name sortKey="Tsui, S K" uniqKey="Tsui S">S. K. Tsui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, T K" uniqKey="Lee T">T. K. Lee</name></author><author><name sortKey="O Rien, K F" uniqKey="O Rien K">K. F. O’Brien</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name></author><author><name sortKey="Johnke, R M" uniqKey="Johnke R">R. M. Johnke</name></author><author><name sortKey="Sheng, C" uniqKey="Sheng C">C. Sheng</name></author><author><name sortKey="Benhabib, S M" uniqKey="Benhabib S">S. M. Benhabib</name></author><author><name sortKey="Wang, T" uniqKey="Wang T">T. Wang</name></author><author><name sortKey="Allison, R R" uniqKey="Allison R">R. R. Allison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, L H" uniqKey="Li L">L. H. Li</name></author><author><name sortKey="Wu, L J" uniqKey="Wu L">L. J. Wu</name></author><author><name sortKey="Tashiro, S I" uniqKey="Tashiro S">S. I. Tashiro</name></author><author><name sortKey="Onodera, S" uniqKey="Onodera S">S. Onodera</name></author><author><name sortKey="Uchiumi, F" uniqKey="Uchiumi F">F. Uchiumi</name></author><author><name sortKey="Ikejima, T" uniqKey="Ikejima T">T. Ikejima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, L J" uniqKey="Li L">L. J. Li</name></author><author><name sortKey="Lai Fu, Z" uniqKey="Lai Fu Z">Z. Lai-Fu</name></author><author><name sortKey="Li Ping, J" uniqKey="Li Ping J">J. Li-Ping</name></author><author><name sortKey="Cheng Yan, G" uniqKey="Cheng Yan G">G. Cheng-Yan</name></author><author><name sortKey="Li Juan, Z" uniqKey="Li Juan Z">Z. Li-Juan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lillo, O" uniqKey="Lillo O">O. Lillo</name></author><author><name sortKey="Bracesco, N" uniqKey="Bracesco N">N. Bracesco</name></author><author><name sortKey="Nunes, E" uniqKey="Nunes E">E. Nunes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Chan, F" uniqKey="Chan F">F. Chan</name></author><author><name sortKey="Sun, H" uniqKey="Sun H">H. Sun</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J. Yan</name></author><author><name sortKey="Fan, D" uniqKey="Fan D">D. Fan</name></author><author><name sortKey="Zhao, D" uniqKey="Zhao D">D. Zhao</name></author><author><name sortKey="An, J" uniqKey="An J">J. An</name></author><author><name sortKey="Zhou, D" uniqKey="Zhou D">D. Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loo, G" uniqKey="Loo G">G. Loo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Madhusoodhanan, R" uniqKey="Madhusoodhanan R">R. Madhusoodhanan</name></author><author><name sortKey="Natarajan, M" uniqKey="Natarajan M">M. Natarajan</name></author><author><name sortKey="Singh, J V" uniqKey="Singh J">J. V. Singh</name></author><author><name sortKey="Jamgade, A" uniqKey="Jamgade A">A. Jamgade</name></author><author><name sortKey="Awasthi, V" uniqKey="Awasthi V">V. Awasthi</name></author><author><name sortKey="Anant, S" uniqKey="Anant S">S. Anant</name></author><author><name sortKey="Herman, T S" uniqKey="Herman T">T. S. Herman</name></author><author><name sortKey="Aravindan, N" uniqKey="Aravindan N">N. Aravindan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mahmood, J" uniqKey="Mahmood J">J. Mahmood</name></author><author><name sortKey="Jelveh, S" uniqKey="Jelveh S">S. Jelveh</name></author><author><name sortKey="Calveley, V" uniqKey="Calveley V">V. Calveley</name></author><author><name sortKey="Zaidi, A" uniqKey="Zaidi A">A. Zaidi</name></author><author><name sortKey="Doctrow, S R" uniqKey="Doctrow S">S. R. Doctrow</name></author><author><name sortKey="Hill, R P" uniqKey="Hill R">R. P. Hill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Majeed, M" uniqKey="Majeed M">M. Majeed</name></author><author><name sortKey="Bhat, B" uniqKey="Bhat B">B. Bhat</name></author><author><name sortKey="Anand, S" uniqKey="Anand S">S. Anand</name></author><author><name sortKey="Sivakumar, A" uniqKey="Sivakumar A">A. Sivakumar</name></author><author><name sortKey="Paliwal, P" uniqKey="Paliwal P">P. Paliwal</name></author><author><name sortKey="Geetha, K G" uniqKey="Geetha K">K. G. Geetha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manna, S K" uniqKey="Manna S">S. K. Manna</name></author><author><name sortKey="Mukhopadhyay, A" uniqKey="Mukhopadhyay A">A. Mukhopadhyay</name></author><author><name sortKey="Aggarwal, B B" uniqKey="Aggarwal B">B. B. Aggarwal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manu, K A" uniqKey="Manu K">K. A. Manu</name></author><author><name sortKey="Leyon, P V" uniqKey="Leyon P">P. V. Leyon</name></author><author><name sortKey="Kuttan, G" uniqKey="Kuttan G">G. Kuttan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mclaughlin, N" uniqKey="Mclaughlin N">N. McLaughlin</name></author><author><name sortKey="Annabi, B" uniqKey="Annabi B">B. Annabi</name></author><author><name sortKey="Lachambre, M P" uniqKey="Lachambre M">M. P. Lachambre</name></author><author><name sortKey="Kim, K S" uniqKey="Kim K">K. S. Kim</name></author><author><name sortKey="Bahary, J P" uniqKey="Bahary J">J. P. Bahary</name></author><author><name sortKey="Moumdjian, R" uniqKey="Moumdjian R">R. Moumdjian</name></author><author><name sortKey="Beliveau, R" uniqKey="Beliveau R">R. Béliveau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meeran, S M" uniqKey="Meeran S">S. M. Meeran</name></author><author><name sortKey="Katiyar, S" uniqKey="Katiyar S">S. Katiyar</name></author><author><name sortKey="Elmets, C A" uniqKey="Elmets C">C. A. Elmets</name></author><author><name sortKey="Katiyar, S K" uniqKey="Katiyar S">S. K. Katiyar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyer, M" uniqKey="Meyer M">M. Meyer</name></author><author><name sortKey="Pahl, H L" uniqKey="Pahl H">H. L. Pahl</name></author><author><name sortKey="Baeuerle, P A" uniqKey="Baeuerle P">P. A. Baeuerle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mouria, M" uniqKey="Mouria M">M. Mouria</name></author><author><name sortKey="Gukovskaya, A S" uniqKey="Gukovskaya A">A. S. Gukovskaya</name></author><author><name sortKey="Jung, Y" uniqKey="Jung Y">Y. Jung</name></author><author><name sortKey="Buechler, P" uniqKey="Buechler P">P. Buechler</name></author><author><name sortKey="Hines, O J" uniqKey="Hines O">O. J. Hines</name></author><author><name sortKey="Reber, H A" uniqKey="Reber H">H. A. Reber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muller, J M" uniqKey="Muller J">J. M. Muller</name></author><author><name sortKey="Rupec, R A" uniqKey="Rupec R">R. A. Rupec</name></author><author><name sortKey="Baeuerle, P A" uniqKey="Baeuerle P">P. A. Baeuerle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murley, J S" uniqKey="Murley J">J. S. Murley</name></author><author><name sortKey="Kataoka, Y" uniqKey="Kataoka Y">Y. Kataoka</name></author><author><name sortKey="Cao, D" uniqKey="Cao D">D. Cao</name></author><author><name sortKey="Li, J J" uniqKey="Li J">J. J. Li</name></author><author><name sortKey="Oberley, L W" uniqKey="Oberley L">L. W. Oberley</name></author><author><name sortKey="Grdina, D J" uniqKey="Grdina D">D. J. Grdina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nair, S" uniqKey="Nair S">S. Nair</name></author><author><name sortKey="Nair, R R" uniqKey="Nair R">R. R. Nair</name></author><author><name sortKey="Srinivas, P" uniqKey="Srinivas P">P. Srinivas</name></author><author><name sortKey="Srinivas, G" uniqKey="Srinivas G">G. Srinivas</name></author><author><name sortKey="Pillai, M R" uniqKey="Pillai M">M. R. Pillai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Navarro, M" uniqKey="Navarro M">M. Navarro</name></author><author><name sortKey="Dotor, E" uniqKey="Dotor E">E. Dotor</name></author><author><name sortKey="Rivera, F" uniqKey="Rivera F">F. Rivera</name></author><author><name sortKey="Sanchez Rovira, P" uniqKey="Sanchez Rovira P">P. Sánchez-Rovira</name></author><author><name sortKey="Vega Villegas, M E" uniqKey="Vega Villegas M">M. E. Vega-Villegas</name></author><author><name sortKey="Cervantes, A" uniqKey="Cervantes A">A. Cervantes</name></author><author><name sortKey="Garcia, J L" uniqKey="Garcia J">J. L. García</name></author><author><name sortKey="Gallen, M" uniqKey="Gallen M">M. Gallén</name></author><author><name sortKey="Aranda, E" uniqKey="Aranda E">E. Aranda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Newcomb, E W" uniqKey="Newcomb E">E. W. Newcomb</name></author><author><name sortKey="Lymberis, S C" uniqKey="Lymberis S">S. C. Lymberis</name></author><author><name sortKey="Lukyanov, Y" uniqKey="Lukyanov Y">Y. Lukyanov</name></author><author><name sortKey="Shao, Y" uniqKey="Shao Y">Y. Shao</name></author><author><name sortKey="Schnee, T" uniqKey="Schnee T">T. Schnee</name></author><author><name sortKey="Devitt, M" uniqKey="Devitt M">M. Devitt</name></author><author><name sortKey="Rosenstein, B S" uniqKey="Rosenstein B">B. S. Rosenstein</name></author><author><name sortKey="Zagzag, D" uniqKey="Zagzag D">D. Zagzag</name></author><author><name sortKey="Formenti, S C" uniqKey="Formenti S">S. C. Formenti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ng, A K" uniqKey="Ng A">A. K. Ng</name></author><author><name sortKey="Bernardo, M V" uniqKey="Bernardo M">M. V. Bernardo</name></author><author><name sortKey="Weller, E" uniqKey="Weller E">E. Weller</name></author><author><name sortKey="Backstrand, K" uniqKey="Backstrand K">K. Backstrand</name></author><author><name sortKey="Silver, B" uniqKey="Silver B">B. Silver</name></author><author><name sortKey="Marcus, K C" uniqKey="Marcus K">K. C. Marcus</name></author><author><name sortKey="Tarbell, N J" uniqKey="Tarbell N">N. J. Tarbell</name></author><author><name sortKey="Stevenson, M A" uniqKey="Stevenson M">M. A. Stevenson</name></author><author><name sortKey="Friedberg, J W" uniqKey="Friedberg J">J. W. Friedberg</name></author><author><name sortKey="Mauch, P M" uniqKey="Mauch P">P. M. Mauch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oehler, C" uniqKey="Oehler C">C. Oehler</name></author><author><name sortKey="Dickinson, D J" uniqKey="Dickinson D">D. J. Dickinson</name></author><author><name sortKey="Broggini Tenzer, A" uniqKey="Broggini Tenzer A">A. Broggini-Tenzer</name></author><author><name sortKey="Hofstetter, B" uniqKey="Hofstetter B">B. Hofstetter</name></author><author><name sortKey="Hollenstein, A" uniqKey="Hollenstein A">A. Hollenstein</name></author><author><name sortKey="Riesterer, O" uniqKey="Riesterer O">O. Riesterer</name></author><author><name sortKey="Vuong, V" uniqKey="Vuong V">V. Vuong</name></author><author><name sortKey="Pruschy, M" uniqKey="Pruschy M">M. Pruschy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okunieff, P" uniqKey="Okunieff P">P. Okunieff</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J. Xu</name></author><author><name sortKey="Hu, D" uniqKey="Hu D">D. Hu</name></author><author><name sortKey="Liu, W" uniqKey="Liu W">W. Liu</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name></author><author><name sortKey="Morrow, G" uniqKey="Morrow G">G. Morrow</name></author><author><name sortKey="Pentland, A" uniqKey="Pentland A">A. Pentland</name></author><author><name sortKey="Ryan, J L" uniqKey="Ryan J">J. L. Ryan</name></author><author><name sortKey="Ding, I" uniqKey="Ding I">I. Ding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Orditura, M" uniqKey="Orditura M">M. Orditura</name></author><author><name sortKey="Galizia, G" uniqKey="Galizia G">G. Galizia</name></author><author><name sortKey="Napolitano, V" uniqKey="Napolitano V">V. Napolitano</name></author><author><name sortKey="Martinelli, E" uniqKey="Martinelli E">E. Martinelli</name></author><author><name sortKey="Pacelli, R" uniqKey="Pacelli R">R. Pacelli</name></author><author><name sortKey="Lieto, E" uniqKey="Lieto E">E. Lieto</name></author><author><name sortKey="Aurilio, G" uniqKey="Aurilio G">G. Aurilio</name></author><author><name sortKey="Vecchione, L" uniqKey="Vecchione L">L. Vecchione</name></author><author><name sortKey="Morgillo, F" uniqKey="Morgillo F">F. Morgillo</name></author><author><name sortKey="Catalano, G" uniqKey="Catalano G">G. Catalano</name></author><author><name sortKey="Ciardiello, F" uniqKey="Ciardiello F">F. Ciardiello</name></author><author><name sortKey="Del Genio, A" uniqKey="Del Genio A">A. Del Genio</name></author><author><name sortKey="Di Martino, N" uniqKey="Di Martino N">N. Di Martino</name></author><author><name sortKey="De Vita, F" uniqKey="De Vita F">F. De Vita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ozgur, E" uniqKey="Ozgur E">E. Ozgur</name></author><author><name sortKey="Guler, G" uniqKey="Guler G">G. Güler</name></author><author><name sortKey="Seyhan, N" uniqKey="Seyhan N">N. Seyhan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pacheco Palencia, L A" uniqKey="Pacheco Palencia L">L. A. Pacheco-Palencia</name></author><author><name sortKey="Noratto, G" uniqKey="Noratto G">G. Noratto</name></author><author><name sortKey="Hingorani, L" uniqKey="Hingorani L">L. Hingorani</name></author><author><name sortKey="Talcott, S T" uniqKey="Talcott S">S. T. Talcott</name></author><author><name sortKey="Mertens Talcott, S U" uniqKey="Mertens Talcott S">S. U. Mertens-Talcott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, E" uniqKey="Park E">E. Park</name></author><author><name sortKey="Hwang, I" uniqKey="Hwang I">I. Hwang</name></author><author><name sortKey="Song, J Y" uniqKey="Song J">J. Y. Song</name></author><author><name sortKey="Jee, Y" uniqKey="Jee Y">Y. Jee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, H R" uniqKey="Park H">H. R. Park</name></author><author><name sortKey="Ju, E J" uniqKey="Ju E">E. J. Ju</name></author><author><name sortKey="Jo, S K" uniqKey="Jo S">S. K. Jo</name></author><author><name sortKey="Jung, U" uniqKey="Jung U">U. Jung</name></author><author><name sortKey="Kim, S H" uniqKey="Kim S">S. H. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, K" uniqKey="Park K">K. Park</name></author><author><name sortKey="Lee, J H" uniqKey="Lee J">J. H. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patt, H M" uniqKey="Patt H">H. M. Patt</name></author><author><name sortKey="Tyree, E B" uniqKey="Tyree E">E. B. Tyree</name></author><author><name sortKey="Straube, R L" uniqKey="Straube R">R. L. Straube</name></author><author><name sortKey="Smith, D E" uniqKey="Smith D">D. E. Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prasad, K N" uniqKey="Prasad K">K. N. Prasad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prasad, K N" uniqKey="Prasad K">K. N. Prasad</name></author><author><name sortKey="Cole, W C" uniqKey="Cole W">W. C. Cole</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raffoul, J J" uniqKey="Raffoul J">J. J. Raffoul</name></author><author><name sortKey="Banerjee, S" uniqKey="Banerjee S">S. Banerjee</name></author><author><name sortKey="Che, M" uniqKey="Che M">M. Che</name></author><author><name sortKey="Knoll, Z E" uniqKey="Knoll Z">Z. E. Knoll</name></author><author><name sortKey="Doerge, D R" uniqKey="Doerge D">D. R. Doerge</name></author><author><name sortKey="Abrams, J" uniqKey="Abrams J">J. Abrams</name></author><author><name sortKey="Kucuk, O" uniqKey="Kucuk O">O. Kucuk</name></author><author><name sortKey="Sarkar, F H" uniqKey="Sarkar F">F. H. Sarkar</name></author><author><name sortKey="Hillman, G G" uniqKey="Hillman G">G. G. Hillman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raffoul, J J" uniqKey="Raffoul J">J. J. Raffoul</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Kucuk, O" uniqKey="Kucuk O">O. Kucuk</name></author><author><name sortKey="Forman, J D" uniqKey="Forman J">J. D. Forman</name></author><author><name sortKey="Sarkar, F H" uniqKey="Sarkar F">F. H. Sarkar</name></author><author><name sortKey="Hillman, G G" uniqKey="Hillman G">G. G. Hillman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raju, U" uniqKey="Raju U">U. Raju</name></author><author><name sortKey="Ariga, H" uniqKey="Ariga H">H. Ariga</name></author><author><name sortKey="Koto, M" uniqKey="Koto M">M. Koto</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X. Lu</name></author><author><name sortKey="Pickett, J" uniqKey="Pickett J">J. Pickett</name></author><author><name sortKey="Valdecanas, D" uniqKey="Valdecanas D">D. Valdecanas</name></author><author><name sortKey="Mason, K A" uniqKey="Mason K">K. A. Mason</name></author><author><name sortKey="Milas, L" uniqKey="Milas L">L. Milas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rao, B N" uniqKey="Rao B">B. N. Rao</name></author><author><name sortKey="Archana, P R" uniqKey="Archana P">P. R. Archana</name></author><author><name sortKey="Aithal, B K" uniqKey="Aithal B">B. K. Aithal</name></author><author><name sortKey="Rao, B S" uniqKey="Rao B">B. S. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rao, B N" uniqKey="Rao B">B. N. Rao</name></author><author><name sortKey="Rao, B S" uniqKey="Rao B">B. S. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rao, B N" uniqKey="Rao B">B. N. Rao</name></author><author><name sortKey="Rao, B S" uniqKey="Rao B">B. S. Rao</name></author><author><name sortKey="Aithal, B K" uniqKey="Aithal B">B. K. Aithal</name></author><author><name sortKey="Kumar, M R" uniqKey="Kumar M">M. R. Kumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rao, S K" uniqKey="Rao S">S. K. Rao</name></author><author><name sortKey="Rao, P S" uniqKey="Rao P">P. S. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rigano, D" uniqKey="Rigano D">D. Rigano</name></author><author><name sortKey="Cardile, V" uniqKey="Cardile V">V. Cardile</name></author><author><name sortKey="Formisano, C" uniqKey="Formisano C">C. Formisano</name></author><author><name sortKey="Maldini, M T" uniqKey="Maldini M">M. T. Maldini</name></author><author><name sortKey="Piacente, S" uniqKey="Piacente S">S. Piacente</name></author><author><name sortKey="Bevelacqua, Y" uniqKey="Bevelacqua Y">Y. Bevelacqua</name></author><author><name sortKey="Russo, A" uniqKey="Russo A">A. Russo</name></author><author><name sortKey="Senatore, F" uniqKey="Senatore F">F. Senatore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosenberg, A" uniqKey="Rosenberg A">A. Rosenberg</name></author><author><name sortKey="Knox, S" uniqKey="Knox S">S. Knox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roy, P" uniqKey="Roy P">P. Roy</name></author><author><name sortKey="Madan, E" uniqKey="Madan E">E. Madan</name></author><author><name sortKey="Kalra, N" uniqKey="Kalra N">N. Kalra</name></author><author><name sortKey="Nigam, N" uniqKey="Nigam N">N. Nigam</name></author><author><name sortKey="George, J" uniqKey="George J">J. George</name></author><author><name sortKey="Ray, R S" uniqKey="Ray R">R. S. Ray</name></author><author><name sortKey="Hans, R K" uniqKey="Hans R">R. K. Hans</name></author><author><name sortKey="Prasad, S" uniqKey="Prasad S">S. Prasad</name></author><author><name sortKey="Shukla, Y" uniqKey="Shukla Y">Y. Shukla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Samarth, R M" uniqKey="Samarth R">R. M. Samarth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sandhya, T" uniqKey="Sandhya T">T. Sandhya</name></author><author><name sortKey="Lathika, K M" uniqKey="Lathika K">K. M. Lathika</name></author><author><name sortKey="Pandey, B N" uniqKey="Pandey B">B. N. Pandey</name></author><author><name sortKey="Bhilwade, H N" uniqKey="Bhilwade H">H. N. Bhilwade</name></author><author><name sortKey="Chaubey, R C" uniqKey="Chaubey R">R. C. Chaubey</name></author><author><name sortKey="Priyadarsini, K I" uniqKey="Priyadarsini K">K. I. Priyadarsini</name></author><author><name sortKey="Mishra, K P" uniqKey="Mishra K">K. P. Mishra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sato, T" uniqKey="Sato T">T. Sato</name></author><author><name sortKey="Kokuba, Y" uniqKey="Kokuba Y">Y. Kokuba</name></author><author><name sortKey="Koizumi, W" uniqKey="Koizumi W">W. Koizumi</name></author><author><name sortKey="Hayakawa, K" uniqKey="Hayakawa K">K. Hayakawa</name></author><author><name sortKey="Okayasu, I" uniqKey="Okayasu I">I. Okayasu</name></author><author><name sortKey="Watanabe, M" uniqKey="Watanabe M">M. Watanabe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scarlatti, F" uniqKey="Scarlatti F">F. Scarlatti</name></author><author><name sortKey="Sala, G" uniqKey="Sala G">G. Sala</name></author><author><name sortKey="Ricci, C" uniqKey="Ricci C">C. Ricci</name></author><author><name sortKey="Maioli, C" uniqKey="Maioli C">C. Maioli</name></author><author><name sortKey="Milani, F" uniqKey="Milani F">F. Milani</name></author><author><name sortKey="Minella, M" uniqKey="Minella M">M. Minella</name></author><author><name sortKey="Botturi, M" uniqKey="Botturi M">M. Botturi</name></author><author><name sortKey="Ghidoni, R" uniqKey="Ghidoni R">R. Ghidoni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwarzenberger, P" uniqKey="Schwarzenberger P">P. Schwarzenberger</name></author><author><name sortKey="Fariss, A" uniqKey="Fariss A">A. Fariss</name></author><author><name sortKey="Linares, L" uniqKey="Linares L">L. Linares</name></author><author><name sortKey="Nedzi, L" uniqKey="Nedzi L">L. Nedzi</name></author><author><name sortKey="Salazar, O M" uniqKey="Salazar O">O. M. Salazar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sharma, K V" uniqKey="Sharma K">K. V. Sharma</name></author><author><name sortKey="Sisodia, R" uniqKey="Sisodia R">R. Sisodia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sharma, P" uniqKey="Sharma P">P. Sharma</name></author><author><name sortKey="Parmar, J" uniqKey="Parmar J">J. Parmar</name></author><author><name sortKey="Sharma, P" uniqKey="Sharma P">P. Sharma</name></author><author><name sortKey="Verma, P" uniqKey="Verma P">P. Verma</name></author><author><name sortKey="Goyal, P K" uniqKey="Goyal P">P. K. Goyal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheehan, J" uniqKey="Sheehan J">J. Sheehan</name></author><author><name sortKey="Ionescu, A" uniqKey="Ionescu A">A. Ionescu</name></author><author><name sortKey="Pouratian, N" uniqKey="Pouratian N">N. Pouratian</name></author><author><name sortKey="Hamilton, D K" uniqKey="Hamilton D">D. K. Hamilton</name></author><author><name sortKey="Schlesinger, D" uniqKey="Schlesinger D">D. Schlesinger</name></author><author><name sortKey="Oskouian, R J" uniqKey="Oskouian R">R. J. Oskouian</name></author><author><name sortKey="Sansur, C" uniqKey="Sansur C">C. Sansur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shimada, M" uniqKey="Shimada M">M. Shimada</name></author><author><name sortKey="Kato, A" uniqKey="Kato A">A. Kato</name></author><author><name sortKey="Habu, T" uniqKey="Habu T">T. Habu</name></author><author><name sortKey="Komatsu, K" uniqKey="Komatsu K">K. Komatsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shin, J I" uniqKey="Shin J">J. I. Shin</name></author><author><name sortKey="Shim, J H" uniqKey="Shim J">J. H. Shim</name></author><author><name sortKey="Kim, K H" uniqKey="Kim K">K. H Kim</name></author><author><name sortKey="Choi, H S" uniqKey="Choi H">H. S. Choi</name></author><author><name sortKey="Kim, J W" uniqKey="Kim J">J. W. Kim</name></author><author><name sortKey="Lee, H G" uniqKey="Lee H">H. G. Lee</name></author><author><name sortKey="Kim, B Y" uniqKey="Kim B">B. Y. Kim</name></author><author><name sortKey="Park, S N" uniqKey="Park S">S. N. Park</name></author><author><name sortKey="Park, O J" uniqKey="Park O">O. J. Park</name></author><author><name sortKey="Yoon, D Y" uniqKey="Yoon D">D. Y. Yoon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shin, S J" uniqKey="Shin S">S. J. Shin</name></author><author><name sortKey="Kim, N K" uniqKey="Kim N">N. K. Kim</name></author><author><name sortKey="Keum, K C" uniqKey="Keum K">K. C. Keum</name></author><author><name sortKey="Kim, H G" uniqKey="Kim H">H. G. Kim</name></author><author><name sortKey="Im, J S" uniqKey="Im J">J. S. Im</name></author><author><name sortKey="Choi, H J" uniqKey="Choi H">H. J. Choi</name></author><author><name sortKey="Baik, S H" uniqKey="Baik S">S. H. Baik</name></author><author><name sortKey="Choen, J H" uniqKey="Choen J">J. H. Choen</name></author><author><name sortKey="Jeung, H C" uniqKey="Jeung H">H. C. Jeung</name></author><author><name sortKey="Rha, S Y" uniqKey="Rha S">S. Y. Rha</name></author><author><name sortKey="Roh, J K" uniqKey="Roh J">J. K. Roh</name></author><author><name sortKey="Chung, H C" uniqKey="Chung H">H. C. Chung</name></author><author><name sortKey="Ahn, J B" uniqKey="Ahn J">J. B. Ahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simone, C B" uniqKey="Simone C">C. B. Simone</name></author><author><name sortKey="Simone, N L" uniqKey="Simone N">N. L. Simone</name></author><author><name sortKey="Simone, V" uniqKey="Simone V">V. Simone</name></author><author><name sortKey="Simone, C B" uniqKey="Simone C">C. B. Simone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singh Gupta, V" uniqKey="Singh Gupta V">V. Singh-Gupta</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H. Zhang</name></author><author><name sortKey="Yunker, C K" uniqKey="Yunker C">C. K. Yunker</name></author><author><name sortKey="Ahmad, Z" uniqKey="Ahmad Z">Z. Ahmad</name></author><author><name sortKey="Zwier, D" uniqKey="Zwier D">D. Zwier</name></author><author><name sortKey="Sarkar, F H" uniqKey="Sarkar F">F. H. Sarkar</name></author><author><name sortKey="Hillman, G G" uniqKey="Hillman G">G. G. Hillman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sinha, M" uniqKey="Sinha M">M. Sinha</name></author><author><name sortKey="Das, D K" uniqKey="Das D">D. K. Das</name></author><author><name sortKey="Bhattacharjee, S" uniqKey="Bhattacharjee S">S. Bhattacharjee</name></author><author><name sortKey="Majumdar, S" uniqKey="Majumdar S">S. Majumdar</name></author><author><name sortKey="Dey, S" uniqKey="Dey S">S. Dey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sisodia, R" uniqKey="Sisodia R">R. Sisodia</name></author><author><name sortKey="Singh, S" uniqKey="Singh S">S. Singh</name></author><author><name sortKey="Sharma, K V" uniqKey="Sharma K">K. V. Sharma</name></author><author><name sortKey="Ahaskar, M" uniqKey="Ahaskar M">M. Ahaskar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Son, E W" uniqKey="Son E">E. W. Son</name></author><author><name sortKey="Mo, S J" uniqKey="Mo S">S. J. Mo</name></author><author><name sortKey="Rhee, D K" uniqKey="Rhee D">D. K. Rhee</name></author><author><name sortKey="Pyo, S" uniqKey="Pyo S">S. Pyo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Srinivasan, M" uniqKey="Srinivasan M">M. Srinivasan</name></author><author><name sortKey="Rajendra, P N" uniqKey="Rajendra P">P. N. Rajendra</name></author><author><name sortKey="Menon, V P" uniqKey="Menon V">V. P. Menon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Staniforth, V" uniqKey="Staniforth V">V. Staniforth</name></author><author><name sortKey="Huang, W C" uniqKey="Huang W">W. C. Huang</name></author><author><name sortKey="Aravindaram, K" uniqKey="Aravindaram K">K. Aravindaram</name></author><author><name sortKey="Yang, N S" uniqKey="Yang N">N. S. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stone, H B" uniqKey="Stone H">H. B. Stone</name></author><author><name sortKey="Coleman, C N" uniqKey="Coleman C">C. N. Coleman</name></author><author><name sortKey="Anscher, M S" uniqKey="Anscher M">M. S. Anscher</name></author><author><name sortKey="Mcbride, W H" uniqKey="Mcbride W">W. H. McBride</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suresh, K" uniqKey="Suresh K">K. Suresh</name></author><author><name sortKey="Vasudevan, D M" uniqKey="Vasudevan D">D. M. Vasudevan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suzuki, M" uniqKey="Suzuki M">M. Suzuki</name></author><author><name sortKey="Amano, M" uniqKey="Amano M">M. Amano</name></author><author><name sortKey="Choi, J" uniqKey="Choi J">J. Choi</name></author><author><name sortKey="Park, H J" uniqKey="Park H">H. J. Park</name></author><author><name sortKey="Williams, B W" uniqKey="Williams B">B. W. Williams</name></author><author><name sortKey="Ono, K" uniqKey="Ono K">K. Ono</name></author><author><name sortKey="Song, C W" uniqKey="Song C">C. W. Song</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Svobodova, A" uniqKey="Svobodova A">A. Svobodová</name></author><author><name sortKey="Zdarilova, A" uniqKey="Zdarilova A">A. Zdarilová</name></author><author><name sortKey="Maliskova, J" uniqKey="Maliskova J">J. Malisková</name></author><author><name sortKey="Mikulkova, H" uniqKey="Mikulkova H">H. Mikulková</name></author><author><name sortKey="Walterova, D" uniqKey="Walterova D">D. Walterová</name></author><author><name sortKey="Vostalova, J" uniqKey="Vostalova J">J. Vostalová</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Szatrowski, T P" uniqKey="Szatrowski T">T. P. Szatrowski</name></author><author><name sortKey="Nathan, C F" uniqKey="Nathan C">C. F. Nathan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Toyokuni, S" uniqKey="Toyokuni S">S. Toyokuni</name></author><author><name sortKey="Okamoto, K" uniqKey="Okamoto K">K. Okamoto</name></author><author><name sortKey="Yodoi, J" uniqKey="Yodoi J">J. Yodoi</name></author><author><name sortKey="Hiai, H" uniqKey="Hiai H">H. Hiai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uma Devi, P" uniqKey="Uma Devi P">P. Uma Devi</name></author><author><name sortKey="Utsumiz, H" uniqKey="Utsumiz H">H. Utsumiz</name></author><author><name sortKey="Takata, M" uniqKey="Takata M">M. Takata</name></author><author><name sortKey="Takeda, S" uniqKey="Takeda S">S. Takeda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vaid, M" uniqKey="Vaid M">M. Vaid</name></author><author><name sortKey="Katiyar, S K" uniqKey="Katiyar S">S. K. Katiyar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Veeraraghavan, J" uniqKey="Veeraraghavan J">J. Veeraraghavan</name></author><author><name sortKey="Aravindan, S" uniqKey="Aravindan S">S. Aravindan</name></author><author><name sortKey="Natarajan, M" uniqKey="Natarajan M">M. Natarajan</name></author><author><name sortKey="Awasthi, V" uniqKey="Awasthi V">V. Awasthi</name></author><author><name sortKey="Herman, T S" uniqKey="Herman T">T. S. Herman</name></author><author><name sortKey="Aravindan, N" uniqKey="Aravindan N">N. Aravindan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Venkatachalam, S R" uniqKey="Venkatachalam S">S. R. Venkatachalam</name></author><author><name sortKey="Chattopadhyay, S" uniqKey="Chattopadhyay S">S. Chattopadhyay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verma, S" uniqKey="Verma S">S. Verma</name></author><author><name sortKey="Younus, J" uniqKey="Younus J">J. Younus</name></author><author><name sortKey="Stys Norman, D" uniqKey="Stys Norman D">D. Stys-Norman</name></author><author><name sortKey="Haynes, A E" uniqKey="Haynes A">A. E. Haynes</name></author><author><name sortKey="Blackstein, M" uniqKey="Blackstein M">M. Blackstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y N" uniqKey="Wang Y">Y. N. Wang</name></author><author><name sortKey="Wu, W" uniqKey="Wu W">W. Wu</name></author><author><name sortKey="Chen, H C" uniqKey="Chen H">H. C. Chen</name></author><author><name sortKey="Fang, H" uniqKey="Fang H">H. Fang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiss, J F" uniqKey="Weiss J">J. F. Weiss</name></author><author><name sortKey="Landauer, M R" uniqKey="Landauer M">M. R. Landauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boyle, P" uniqKey="Boyle P">P. Boyle</name></author><author><name sortKey="Levin, B E" uniqKey="Levin B">B. E. Levin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xie, C H" uniqKey="Xie C">C. H. Xie</name></author><author><name sortKey="Zhang, M S" uniqKey="Zhang M">M. S. Zhang</name></author><author><name sortKey="Zhou, Y F" uniqKey="Zhou Y">Y. F. Zhou</name></author><author><name sortKey="Han, G" uniqKey="Han G">G. Han</name></author><author><name sortKey="Cao, Z" uniqKey="Cao Z">Z. Cao</name></author><author><name sortKey="Zhou, F X" uniqKey="Zhou F">F. X. Zhou</name></author><author><name sortKey="Zhang, G" uniqKey="Zhang G">G. Zhang</name></author><author><name sortKey="Luo, Z G" uniqKey="Luo Z">Z. G. Luo</name></author><author><name sortKey="Wu, J P" uniqKey="Wu J">J. P. Wu</name></author><author><name sortKey="Liu, H" uniqKey="Liu H">H. Liu</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author><author><name sortKey="Zhang, W J" uniqKey="Zhang W">W. J. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, E S" uniqKey="Yang E">E. S. Yang</name></author><author><name sortKey="Choi, M J" uniqKey="Choi M">M. J. Choi</name></author><author><name sortKey="Kim, J H" uniqKey="Kim J">J. H. Kim</name></author><author><name sortKey="Choi, K S" uniqKey="Choi K">K. S. Choi</name></author><author><name sortKey="Kwon, T K" uniqKey="Kwon T">T. K. Kwon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, E S" uniqKey="Yang E">E. S. Yang</name></author><author><name sortKey="Choi, M J" uniqKey="Choi M">M. J. Choi</name></author><author><name sortKey="Kim, J H" uniqKey="Kim J">J. H. Kim</name></author><author><name sortKey="Choi, K S" uniqKey="Choi K">K. S. Choi</name></author><author><name sortKey="Kwon, T K" uniqKey="Kwon T">T. K. Kwon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Y P" uniqKey="Yang Y">Y. P. Yang</name></author><author><name sortKey="Chang, Y L" uniqKey="Chang Y">Y. L. Chang</name></author><author><name sortKey="Huang, P I" uniqKey="Huang P">P. I. Huang</name></author><author><name sortKey="Chiou, G Y" uniqKey="Chiou G">G. Y. Chiou</name></author><author><name sortKey="Tseng, L M" uniqKey="Tseng L">L. M. Tseng</name></author><author><name sortKey="Chiou, S H" uniqKey="Chiou S">S. H. Chiou</name></author><author><name sortKey="Chen, M H" uniqKey="Chen M">M. H. Chen</name></author><author><name sortKey="Chen, M T" uniqKey="Chen M">M. T. Chen</name></author><author><name sortKey="Shih, Y H" uniqKey="Shih Y">Y. H. Shih</name></author><author><name sortKey="Chang, C H" uniqKey="Chang C">C. H. Chang</name></author><author><name sortKey="Hsu, C C" uniqKey="Hsu C">C. C. Hsu</name></author><author><name sortKey="Ma, H I" uniqKey="Ma H">H. I. Ma</name></author><author><name sortKey="Wang, C T" uniqKey="Wang C">C. T. Wang</name></author><author><name sortKey="Tsai, L L" uniqKey="Tsai L">L. L. Tsai</name></author><author><name sortKey="Yu, C C" uniqKey="Yu C">C. C. Yu</name></author><author><name sortKey="Chang, C J" uniqKey="Chang C">C. J. Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoon, J H" uniqKey="Yoon J">J. H. Yoon</name></author><author><name sortKey="Lim, T G" uniqKey="Lim T">T. G. Lim</name></author><author><name sortKey="Lee, K M" uniqKey="Lee K">K. M. Lee</name></author><author><name sortKey="Jeon, A J" uniqKey="Jeon A">A. J. Jeon</name></author><author><name sortKey="Kim, S Y" uniqKey="Kim S">S. Y. Kim</name></author><author><name sortKey="Lee, K W" uniqKey="Lee K">K. W. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="You, W C" uniqKey="You W">W. C. You</name></author><author><name sortKey="Hsieh, C C" uniqKey="Hsieh C">C. C. Hsieh</name></author><author><name sortKey="Huang, J T" uniqKey="Huang J">J. T. Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="You, W C" uniqKey="You W">W. C. You</name></author><author><name sortKey="Lin, W C" uniqKey="Lin W">W. C. Lin</name></author><author><name sortKey="Huang, J T" uniqKey="Huang J">J. T. Huang</name></author><author><name sortKey="Hsieh, C C" uniqKey="Hsieh C">C. C. Hsieh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, R" uniqKey="Yu R">R. Yu</name></author><author><name sortKey="Hebbar, V" uniqKey="Hebbar V">V. Hebbar</name></author><author><name sortKey="Kim, D W" uniqKey="Kim D">D. W. Kim</name></author><author><name sortKey="Mandlekar, S" uniqKey="Mandlekar S">S. Mandlekar</name></author><author><name sortKey="Pezzuto, J M" uniqKey="Pezzuto J">J. M. Pezzuto</name></author><author><name sortKey="Kong, A N" uniqKey="Kong A">A. N. Kong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y. Zhao</name></author><author><name sortKey="Cao, J" uniqKey="Cao J">J. Cao</name></author><author><name sortKey="Ma, H" uniqKey="Ma H">H. Ma</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Pharmacol</journal-id><journal-id journal-id-type="publisher-id">Front. Pharmacol.</journal-id><journal-title-group><journal-title>Frontiers in Pharmacology</journal-title></journal-title-group><issn pub-type="epub">1663-9812</issn><publisher><publisher-name>Frontiers Research Foundation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22291649</article-id><article-id pub-id-type="pmc">3253585</article-id><article-id pub-id-type="doi">10.3389/fphar.2011.00094</article-id><article-categories><subj-group subj-group-type="heading"><subject>Pharmacology</subject><subj-group><subject>Review Article</subject></subj-group></subj-group></article-categories><title-group><article-title>The Prospective Role of Plant Products in Radiotherapy of Cancer: A Current Overview</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Hazra</surname><given-names>Banasri</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn001">*</xref></contrib><contrib contrib-type="author"><name><surname>Ghosh</surname><given-names>Subhalakshmi</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kumar</surname><given-names>Amit</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pandey</surname><given-names>B. N.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>Department of Pharmaceutical Technology, Jadavpur University</institution><country>Kolkata, India</country></aff><aff id="aff2"><sup>2</sup><institution>Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre</institution><country>Mumbai, India</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Xue-Jun Sun, Taishan Medical College, China</p></fn><fn fn-type="edited-by"><p>Reviewed by: Wenwu Liu, Second Military Medical University, China; Sheng Chen, Zhejiang University, China</p></fn><corresp id="fn001">*Correspondence: Banasri Hazra, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, India. e-mail: <email>banasrihazra@yahoo.co.in</email></corresp><fn fn-type="other" id="fn002"><p>This article was submitted to Frontiers in Ethnopharmacology, a specialty of Frontiers in Pharmacology.</p></fn></author-notes><pub-date pub-type="epub"><day>09</day><month>1</month><year>2012</year></pub-date><pub-date pub-type="collection"><year>2011</year></pub-date><volume>2</volume><elocation-id>94</elocation-id><history><date date-type="received"><day>04</day><month>11</month><year>2011</year></date><date date-type="accepted"><day>22</day><month>12</month><year>2011</year></date></history><permissions><copyright-statement>Copyright © 2012 Hazra, Ghosh, Kumar and Pandey.</copyright-statement><copyright-year>2012</copyright-year><license license-type="open-access" xlink:href="http://www.frontiersin.org/licenseagreement"><license-p>This is an open-access article distributed under the terms of the <uri xlink:type="simple" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">Creative Commons Attribution Non Commercial License</uri>, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.</license-p></license></permissions><abstract><p>Treatment of cancer often requires exposure to radiation, which has several limitations involving non-specific toxicity toward normal cells, reducing the efficacy of treatment. Efforts are going on to find chemical compounds which would effectively offer protection to the normal tissues after radiation exposure during radiotherapy of cancer. In this regard, plant-derived compounds might serve as “leads” to design ideal radioprotectors/radiosensitizers. This article reviews some of the recent findings on prospective medicinal plants, phytochemicals, and their analogs, based on both <italic>in vitro</italic> and <italic>in vivo</italic> tumor models especially focused with relevance to cancer radiotherapy. Also, pertinent discussion has been presented on the molecular mechanism of apoptotic death in relation to the oxidative stress in cancer cells induced by some of these plant samples and their active constituents.</p></abstract><kwd-group><kwd>medicinal plants</kwd><kwd>phytochemicals</kwd><kwd>radioprotectors</kwd><kwd>radiosensitizers</kwd><kwd>cancer radiotherapy</kwd><kwd>ionizing radiation</kwd></kwd-group><counts><fig-count count="0"></fig-count><table-count count="2"></table-count><equation-count count="0"></equation-count><ref-count count="172"></ref-count><page-count count="13"></page-count><word-count count="12814"></word-count></counts></article-meta></front><body><sec><title>Introduction</title><p>Cancer is now the third leading cause of death worldwide, with an estimated 12 million new cases and 7.6 million cancer deaths reported in American Cancer Society (<xref ref-type="bibr" rid="B8">2007</xref>). It is projected that by 2030 there would be about 26 million new cases, while a majority of deaths due to cancer will occur in developing countries (Bray and Moller, <xref ref-type="bibr" rid="B21">2006</xref>; World Cancer Report, <xref ref-type="bibr" rid="B163">2008</xref>). In the meantime, the global distribution of cancer along with the predominating types of the disease continues to change. Thus, cancers of the lung, breast, colon/rectum, and prostate are no longer confined to the Western industrialized countries but are among the most common cancers occurring all over the world. As for the therapy and management of cancer, newer strategies comprising multi-faceted and integrative approach involving surgery, followed by chemotherapy along with radiation is currently gaining consensus (Oehler et al., <xref ref-type="bibr" rid="B111">2007</xref>). At the same time, advancement in the understanding of the disease processes at molecular level has offered novel targets for prevention, detection, control, and elimination of cancer.</p><p>Application of ionizing radiation, over and above surgery, and chemotherapy, has been the treatment of choice in case of solid malignancies (Kinsella, <xref ref-type="bibr" rid="B78">2011</xref>). However, a substantial fraction of such tumors would fail to respond well to the radiation treatment, and require a very high dose to get killed, posing a severe limitation to the radiotherapy. Additionally, undesirable complications would occur owing to radiation injury to the surrounding normal tissues and to the skin, brain, heart, lung, kidney, liver, or gastrointestinal system of the cancer patient. Also, symptoms like tissue fibrosis, hair loss, xerostomia, xerophthalmia, etc., considerably restrict the application of a high dose of radiation aimed at the tumor-bearing organs (Dest, <xref ref-type="bibr" rid="B32">2006</xref>).</p><p>Moreover, co-administration of radiation (delivered in the range of 40–80 Gy) along with the chemotherapeutic regimen might aggravate these complications (Curry and Curran, <xref ref-type="bibr" rid="B29">2003</xref>). Patients undergoing treatment with taxol or vincristine often suffer from peripheral neuropathy as a side effect, while anthracycline drugs like doxorubicin (adriamycin), epirubicin, and mitoxantrone, etc., might lead to cardiac dysfunction (Choy, <xref ref-type="bibr" rid="B27">2001</xref>). Abnormal kidney function and hearing loss were some of the common adverse effects occurring upon radiotherapy given to patients under treatment with platinum compounds (Amorino et al., <xref ref-type="bibr" rid="B9">2000</xref>). Combination with some of the alkylating agents, like cyclophosphamide, ifosfamide, and leukeran (chlorambucil), might cause infertility (Verma et al., <xref ref-type="bibr" rid="B160">2007</xref>). Again, a long term problem might emerge due to the post-radiotherapy incidence of a second tumor appearing either at the site of irradiation or away from it (Ng et al., <xref ref-type="bibr" rid="B110">2002</xref>). Hence, it is a major challenge to radiation oncologists and researchers to develop alternative approaches to minimize the dosage through selective sensitization of tumor cells to respond to the radiation treatment, and thereby evade the detrimental consequences of radiotherapy (Rosenberg and Knox, <xref ref-type="bibr" rid="B130">2006</xref>).</p><p>The exposure to radiation would primarily generate intracellular reactive oxygen species (ROS, viz., superoxide and hydroxyl radicals), which in turn would lead to DNA strands breaks and conformational alterations of biomolecules (Halliwell and Gutteridge, <xref ref-type="bibr" rid="B48">1989</xref>). This will inevitably cause damage to surrounding normal cells. Hence, certain compounds/formulations could be envisaged to effectively scavenge the free radicals and thereby protect the surrounding normal cells from radiation induced injury. Historically, the seminal findings on the radioprotective ability of naturally occurring amino-metabolites like cysteine and cysteamine triggered the search for other thiolamines which would protect us from the acute effects of radiation (Patt et al., <xref ref-type="bibr" rid="B119">1949</xref>). Thus, amifostine ([<italic>S</italic>-2-[3-aminopropylamino] ethylphosphorothioic acid) was developed as a potential radioprotector molecule (Weiss and Landauer, <xref ref-type="bibr" rid="B162">2000</xref>; Grdina et al., <xref ref-type="bibr" rid="B43">2002</xref>; Bensadoun et al., <xref ref-type="bibr" rid="B19">2006</xref>). Nevertheless, its wider applicability has been restricted due to the major limitations associated with nausea, diarrhea, hypotension, hypocalcaemia, sleeplessness, dizziness, nephro- and neuro-toxic effects. Other non-protein thiols possessing antioxidative properties, viz. captopril ([<italic>S</italic>]-1-[3-mercapto-2-methyl-1-oxo-propyl]-<sc>l</sc>-proline), mesna (sodium-2-mercapto-ethanesulfonate), and <italic>N</italic>-acetyl-<sc>l</sc>-cysteine (NAC), were also relevant in this regard (Murley et al., <xref ref-type="bibr" rid="B106">2004</xref>). However, these exogenous antioxidants proved to be ineffective if administered at the post-irradiation stage. These scavengers, acting only for a limited period of time (15 min to 1 h under <italic>in vivo</italic> conditions), must be administered shortly before the radiation exposure as the generation of highly reactive free radicals following radiation is a very rapid process, spanning less than 10<sup>−3</sup> s (Grdina et al., <xref ref-type="bibr" rid="B43">2002</xref>). Hence, there is an urgent need to look for more suitable molecules to be used in combination with chemo- and radio-therapy of cancer in order to minimize the adverse effects, and to enhance the overall curative outcome in the patients.</p><p>Screening and testing of compounds from natural as well as synthetic sources have been carried out over the last few decades in order to find effective radioprotectors capable of inhibiting radiation damage not only during radiotherapy of cancer patients, but also to healthy individuals undergoing occupational and accidental exposures to radiation (Stone et al., <xref ref-type="bibr" rid="B150">2003</xref>). In this context, several authors have reviewed the prospective application of traditional medicinal plants which are known to contain anti-inflammatory, antioxidant, and immunomodulatory compounds (Arora et al., <xref ref-type="bibr" rid="B12">2005</xref>; Venkatachalam and Chattopadhyay, <xref ref-type="bibr" rid="B159">2005</xref>; Jagetia, <xref ref-type="bibr" rid="B59">2007</xref>). Again, plant-derived polyphenolic compounds with radiosensitizing property have been extensively reviewed elsewhere (Garg et al., <xref ref-type="bibr" rid="B41">2005</xref>). Incidentally, some of these antioxidants and plant products were also shown to be effective in prevention of cancer incidence (Suresh and Vasudevan, <xref ref-type="bibr" rid="B151">1994</xref>; Zhao et al., <xref ref-type="bibr" rid="B172">1997</xref>; Lee et al., <xref ref-type="bibr" rid="B89">2002</xref>; Girdhani et al., <xref ref-type="bibr" rid="B42">2005</xref>). The present article would be following up these developments during the last 5 years, and aim to highlight the current endeavor (since 2006) to identify phytochemicals and secondary metabolites of medicinal plants with relevance to cancer radiotherapy, and at the same time, attempt to elucidate the mechanistic premise in the light of available reports.</p></sec><sec><title>Potential Plant Products for Application in Cancer Radiotherapy</title><p>The global search for naturally occurring phytochemicals as potential radiotherapeutic agents has unearthed a host of plant products broadly categorized as (i) “radioprotectors”- to ameliorate the undesired damages caused to the normal cells, hence, minimize the side effects of radiation therapy; and (ii) “radiosensitizers”- to enhance the radiation-induced cell death inflicted to the tumor, and thereby minimize the dose of radiation treatment. In the present article, some of the major findings on traditional medicinal plants and active phytochemicals with promising radioprotective or radiosensitizing efficacy have been briefly summarized in a tabular form (Tables <xref ref-type="table" rid="T1">1</xref> and <xref ref-type="table" rid="T2">2</xref>; post-2006).</p><table-wrap id="T1" position="float"><label>Table 1</label><caption><p><bold>Traditional medicinal plants and/or their bioactive constituents with prospective radioprotective/radiosensitizing efficacy (2006–2011)</bold>.</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1">Plants (family)</th><th valign="top" align="left" rowspan="1" colspan="1">Radioprotective/radiosensitizing efficacy of extracts/fractions</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Aegle marmelos</italic> (L.) Corr. (Rutaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Extracts protected mice against radiation-induced decline in hemoglobin, total leukocyte, and lymphocytes counts, and the clonogenicity of hemopoietic progenitor cells; decreased lipid peroxidation accompanied by a significant elevation in the GSH concentration in the mouse intestine; elevated the peripheral cell count as well as villus height and crypt number accompanied by a decline in goblet and dead cells; hydroalcoholic leaf extract significantly reduced micro nucleated polychromatic, normo chromatic erythrocytes, and polychromatic/normochromatic erythrocyte ratio in γ-irradiated mice bone marrow cells (Baliga et al., <xref ref-type="bibr" rid="B16">2010</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Aloe arborescens</italic> Mill. (Liliaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Leaf extract showed radioprotective efficacy (Bakuridze et al., <xref ref-type="bibr" rid="B15">2009</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Alstonia scholaris</italic> L. (Apocynaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Hydro-alcoholic extract of bark exhibited radioprotective efficacy in γ-irradiated mice (7.5 Gy) through lowering of lipid peroxidation with significant increase in glutathione levels in serum as well as in liver (Gupta et al., <xref ref-type="bibr" rid="B45">2008</xref>); combination treatment of bark extract with γ-radiation (2.5 Gy) exhibited decrease in lipid peroxidation and increase in GSH level; protected against radiation-induced chromosomal damage and micronuclei induction in mice bone marrow (Jahan and Goyal, <xref ref-type="bibr" rid="B63">2010</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Angelica sinensis</italic> (Oliv.) Diels (Apiaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Root extract down-regulated hydroxyproline and Tgfb1 and provides protection in mice with radiation-induced pulmonary fibrosis (Han et al., <xref ref-type="bibr" rid="B49">2006</xref>); suppressed TNF-α and TGF-β1 expression in irradiated lung tissue in mice (Xie et al., <xref ref-type="bibr" rid="B164">2006</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Aphanamixis polystachya</italic> (Wall.) (Meliaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Ethyl acetate fraction of the stem bark reduced radiation-induced chromosome damage in mice through free radical scavenging and reduction of lipid peroxidation activity (Jagetia and Venkatesha, <xref ref-type="bibr" rid="B62">2006</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Azadirachta indica</italic> (L.) Adelb. (Meliaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Leaf extracts exhibited radiosensitizing effect by activating pro-apoptotic signals in neuroblastoma xenografts exposed to single (10 Gy) or fractionated (2 Gy/day × 5 day) doses of radiation (Veeraraghavan et al., <xref ref-type="bibr" rid="B158">2011</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Biophytum sensitivum</italic> (L.) DC. (Oxalidaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Methanol extract protected γ-radiation-induced hemopoietic damage through immunomodulation as well as sequential induction of IL-1β, GM-CSF, and IFN-γ (Guruvayoorappan and Kuttan, <xref ref-type="bibr" rid="B46">2008</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Boerhaavia diffusa</italic> L. (Nyctaginaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Whole-plant extract prevented γ-radiation-induced DNA damage in mice bone marrow(Manu et al., <xref ref-type="bibr" rid="B100">2007</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Citrus sinensis</italic> (L.) Osbeck (Rutaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Potentially counteracted UV-B-induced damage in human keratinocytes (HaCaT), through NF-κB and AP-1 translocation and procaspase-3 cleavage (Cimino et al., <xref ref-type="bibr" rid="B28">2007</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Emblica officinalis</italic> L. (Phyllanthaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Extract demonstrated significant depletion in lipid peroxidation and elevation in glutathione and catalase levels before γ-irradiation (5 Gy) to mice (Jindal et al., <xref ref-type="bibr" rid="B68">2009</xref>); fruit extract inhibited UV-induced ROS and collagen damage in human dermal fibroblast (Adil et al., <xref ref-type="bibr" rid="B4">2010</xref>; Majeed et al., <xref ref-type="bibr" rid="B98">2011</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Genista sessilifolia</italic> DC. and <italic>Genista tinctoria</italic> L. (Leguminosae)</td><td valign="top" align="left" rowspan="1" colspan="1">Methanol extract of the aerial part inhibited UV light and nitric oxide-induced DNA damage on plasmid vector pBR322 and human melanoma (M14) cell growth (Rigano et al., <xref ref-type="bibr" rid="B129">2009</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Grewia asiatica</italic> L. (Malvaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Post-treatment of fruit pulp extract inhibited γ-radiation-induced glutathione depletion and ameliorating lipid peroxidation levels in mice (Sisodia et al., <xref ref-type="bibr" rid="B146">2008</xref>; Sharma and Sisodia, <xref ref-type="bibr" rid="B137">2009</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Isatis indigotica</italic> Fort. (Brassicaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Root exhibited anti-inflammatory ability to reduce the mucosal damage caused by radiation (You et al., <xref ref-type="bibr" rid="B169">2009a</xref>); reduced serum TNF-α, IL-1β, and IL-6 level along with restoration of leukocytopenia following whole body irradiation in mice (You et al., <xref ref-type="bibr" rid="B170">2009b</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Mentha piperita</italic> and <italic>Mentha arvensis</italic> (Lamiaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Protected against γ-radiation-induced hematopoietic damage in bone marrow of mice by significantly decreasing micronucleus formation and increasing erythropoietin level (Samarth, <xref ref-type="bibr" rid="B132">2007</xref>); aqueous extract showed radio-protecting efficacy in testis, gastrointestinal and hemopoetic systems in mice through free radical scavenging, antioxidant, metal chelating, anti-inflammatory, antimutagenic, and enhancement of the DNA repair processes (Baliga and Rao, <xref ref-type="bibr" rid="B17">2010</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Moringa oleifera</italic> Lam. (Moringaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Aqueous ethanolic leaf extract protected against γ-radiation-induced liver damage in mice through inhibition of of NF-κB translocation and lipid peroxidation, with increases in SOD, CAT, GSH, and FRAP (Sinha et al., <xref ref-type="bibr" rid="B145">2011</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Olea europaea</italic> L. (Oleaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Prevented UV-B-induced skin damage in hairless mice by inhibiting the expression of matrix metalloproteinase MMP-2, MMP-9, and MMP-13, vascular endothelial growth factor (VEGF), and cyclooxygenase-2 (COX-2) in the skin; histological evaluation showed suppression of Ki-67 and CD31-positive cells expression induced by irradiation (Kimura and Sumiyoshi, <xref ref-type="bibr" rid="B77">2009</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Panax ginseng</italic> L. (Araliaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Red ginseng showed photoprotective effect of against ultraviolet radiation-induced chronic skin damage in the hairless mouse (Lee et al., <xref ref-type="bibr" rid="B88">2009</xref>); radioprotective potential on human lymphocytes when applied at 90 min post-irradiation, through scavenging free radicals and enhancement of intracellular total antioxidant capacity; inhibited radiation-induced (7 Gy) apoptosis in gastrointestinal tract of small intestine by decreasing pro-apoptotic p53 and Bax as well as augmenting anti-apoptotic Bcl-2 following 24 h after irradiation; increase γ-ray-induced apoptotic cell death in human lung cancer cells (NCI-H460, both in culture and in nude mice xenograft model) through intracellular ROS generation, nuclear fragmentation, mitochondrial membrane potential loss, and activation of caspase-3; inhibited micronuclei formation in human peripheral blood lymphocytes following 1–2 Gy radiation exposure (Lee et al., <xref ref-type="bibr" rid="B87">2008b</xref>, <xref ref-type="bibr" rid="B90">2010</xref>; Park et al., <xref ref-type="bibr" rid="B116">2011</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Phyllanthus amarus</italic> Schum. and Thonn. (Phyllanthaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Found to protect the clastogenic effects of radiation as seen from decreased number of micronuclei and chromosomal aberrations percentage (Harikumar and Kuttan, <xref ref-type="bibr" rid="B51">2007</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Pothomorphe umbellate</italic> C. DC. (Piperaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Inhibited UV-B-induced hyperplasic response and increased p53-positive cells in hairless mouse epidermis (da Silva et al., <xref ref-type="bibr" rid="B30">2009</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Punica granatum</italic> Linn. (Lythraceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Showed protective effects in UV-A and UV-B irradiated human skin fibroblasts (Pacheco-Palencia et al., <xref ref-type="bibr" rid="B115">2008</xref>); fruit extract inhibited UV-B radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis through suppressing nuclear translocation of NF-κB, activation of IKKα, phosphorylation, and degradation of IκBα; pomegranate-derived products, viz., POMx juice, POMx extract, and pomegranate oil (POMo) inhibited UV-B-induced (i) collagenase (MMP-1), (ii) gelatinase (MMP-2, MMP-9), (iii) stromelysin (MMP-3), (iv) matrilysin (MMP-7), (v) elastase (MMP-12), and (vi) tropoelastin c-Fos and phosphorylation of c-Jun protein expression in reconstituted human skin (EpiDerm(TM) FT-200; Afaq et al., <xref ref-type="bibr" rid="B6">2009</xref>, <xref ref-type="bibr" rid="B5">2010</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Rosmarinus officinalis</italic> L. (Lamiaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Extract inhibited γ-radiation (3 Gy) induced lipid peroxidation and elevated glutathione levels in irradiated mice (Jindal et al., <xref ref-type="bibr" rid="B67">2010</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Rubus</italic> spp.(Rosaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Inhibited UV-induced activation of NF-κB and AP-1 in cultured mouse epidermal cells (Huang et al., <xref ref-type="bibr" rid="B56">2007</xref>); sensitized human breast cancer cell line (MCF-7) to radiation by inhibiting radiation-induced activation of NF-κB, and NF-κB regulated IAP1, IAP2, XIAP, and surviving activity, suppressed IR-induced TNFα, IL-1α, and MnSOD levels (Madhusoodhanan et al., <xref ref-type="bibr" rid="B96">2010</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Syzygium cumini</italic> L. Skeels (Myrtaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Extract inhibited γ-radiation-induced DNA damage through scavenging of free radicals in cultured splenocytes of mice (Jagetia et al., <xref ref-type="bibr" rid="B61">2011</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Tinospora cordifolia</italic> (Thunb.) Miers. (Ranunculaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Combination treatment of dichloromethane extract with γ-radiation (1–4 Gy) declined viability of HeLa cells by increasing lactate dehydrogenase and decreasing glutathione S-transferase activity (Rao and Rao, <xref ref-type="bibr" rid="B128">2010b</xref>); prevented radiation-induced testicular injury (Sharma et al., <xref ref-type="bibr" rid="B138">2011</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Viscum album</italic> L. (Santalaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Reduced side effects of conventional radiotherapy in cancer (Kienle and Kiene, <xref ref-type="bibr" rid="B76">2010</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>Xylopia aethiopica</italic> (Dunal) A. Rich (Anonaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Combination treatment with Vit.C protected against γ-radiation-induced testicular damage in rats through antioxidant activity (Adaramoye et al., <xref ref-type="bibr" rid="B1">2010a</xref>); dried fruit extract attenuated serum alanine and aspartate aminotransferases level in whole body irradiated rats (Adaramoye et al., <xref ref-type="bibr" rid="B2">2011</xref>); methanol extract of fruit reduced γ-radiation-induced oxidative stress in brain of adult male Wistar rats (Adaramoye et al., <xref ref-type="bibr" rid="B3">2010b</xref>)</td></tr></tbody></table></table-wrap><table-wrap id="T2" position="float"><label>Table 2</label><caption><p><bold>Phytochemicals with prospective radioprotective/radiosensitizing efficacy: reports from last 5 years study</bold>.</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1">Compounds/plants (family)</th><th valign="top" align="left" rowspan="1" colspan="1">Radioprotective/radiosensitizing efficacy (reference)</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Allicin</bold>/<italic>Allium sativum</italic> L. Gaertn. (Alliaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Down-regulated γ-ray-induced ICAM-1 expression via inhibition of both AP-1 activation and JNK pathway in human umbilical vein endothelial cells (HUVECs; Son et al., <xref ref-type="bibr" rid="B147">2006</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Betulinic acid</bold>/<italic>Ziziphus mauritiana</italic> Lam. (Rhamnaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Enhanced cellular toxicity with decreased clonogenic survival in combination with radiation (4 Gy) on redioresistant head and neck squamous carcinoma cell line (Eder-Czembirek et al., <xref ref-type="bibr" rid="B37">2010</xref>); induced cytotoxicity and radiosensitivity in glioma cells under hypoxic conditions (Bache et al., <xref ref-type="bibr" rid="B13">2011</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Camptothecin (Irinotecan)</bold>/<italic>Camptotheca acuminata</italic> Decne (Nyssaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Concurrent chemoradiation with capecitabine and weekly irinotecan showed promising efficacy in preoperative treatment for rectal cancer (Phase I and II study; (Klautke et al., <xref ref-type="bibr" rid="B79">2006</xref>); preoperative radiotherapy and weekly irinotecan in combination with protracted venous infusion of 5-FU found effective in advanced rectal cancer (Phase II study; Navarro et al., <xref ref-type="bibr" rid="B108">2006</xref>); irinotecan plus cisplatin with concurrent radiotherapy showed effectiveness for patients with limited-disease small cell lung cancer (Phase II study; Jeong et al., <xref ref-type="bibr" rid="B64">2006</xref>); preoperative chemotherapy with S-1 and irinotecan sensitized radiation therapy in patients with locally advanced rectal cancer (Phase I/II study; Sato et al., <xref ref-type="bibr" rid="B134">2007</xref>; Shin et al., <xref ref-type="bibr" rid="B142">2010</xref>); weekly irinotecan and cisplatin induced effectiveness of radical thoracic radiation in locally advanced non-small cell lung carcinoma (Phase I study; Langer et al., <xref ref-type="bibr" rid="B84">2007</xref>); combination of cetuximab, bevacizumab, and irinotecan sensitized radiation therapy in patients with primary glioblastoma and prevented progression after treatment (Phase II trial; Hasselbalch et al., <xref ref-type="bibr" rid="B52">2010</xref>); topoisomerase I as possible target for radiosensitizing effect of irinotecan in rectal cancer (Illum, <xref ref-type="bibr" rid="B58">2011</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Crocetin (Trans sodium crocetinate)</bold>/<italic>Crocus sativus</italic> Linn. (Iridaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Combination regimen with radiation enhanced the efficiency of radiotherapy by increased oxygen diffusion in the brain and elevated the partial brain oxygen level in rat C6 glioma model (Sheehan et al., <xref ref-type="bibr" rid="B139">2008</xref>); induced apoptosis through inhibiting nucleic acid synthesis, and hindering growth factor signaling pathways (Gutheil et al., <xref ref-type="bibr" rid="B47">2011</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Curcumin</bold>/<italic>Curcuma longa</italic> Linn. (Zingiberaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Protected γ-radiation-induced DNA damage and lipid peroxidation in cultured human lymphocytes (Srinivasan et al., <xref ref-type="bibr" rid="B148">2006</xref>); demonstrated protective effect on radiation-induced (50 Gy) cutaneous damage in mice characterized by downregulation of IL-1 IL-6, IL-18, TNF-α, lymphotoxin-β, and TGF-β in irradiated skin and muscle (Okunieff et al., <xref ref-type="bibr" rid="B112">2006</xref>); prevented radiation-induced incidence of thymic lymphoma in mice (Dange et al., <xref ref-type="bibr" rid="B31">2007</xref>) and ileal mucosal damage in rat (Akpolat et al., <xref ref-type="bibr" rid="B7">2009</xref>) through antioxidant property; combination with visible light inhibits human epithelial carcinoma A431 tumor growth in a xenograft model in mice through ERK1/2 and EGF-R inhibition leading to apoptosis (Dujic et al., <xref ref-type="bibr" rid="B36">2009</xref>); accelerated wound repair in excision wound of mice exposed to fractionated γ-radiation (Jagetia and Rajanikant, <xref ref-type="bibr" rid="B60">2011</xref>); significantly inhibited IR-induced NF-κB, telomerase and telomerase reverse transcriptase promoter mRNA (TERT) activation in human neuroblastoma cells (Aravindan et al., <xref ref-type="bibr" rid="B11">2011</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Diospyrin (Diospyrin dimethylether)</bold>/<italic>Diospyros montana</italic> Roxb. (Ebenaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Enhanced radiation-induced cytotoxicity and apoptosis in human breast cancer cell line (MCF-7) through down-regulation of Bcl-2 and COX-2 gene, and up-regulation of p53 and p21 (Kumar et al., <xref ref-type="bibr" rid="B81">2007</xref>); showed enhancement in cytotoxicity and apoptotic induction and decrease in clonogenic survival of human and mouse fibrosarcoma cells by inhibiting radiation-induced NF-κB activation, generation of intracellular reactive oxygen species, caused significant suppression of tumor growth <italic>in vivo</italic>, and restoration of liver enzyme activity to the “normal” level (Kumar et al., <xref ref-type="bibr" rid="B82">2008</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>β-Elemene</bold>/<italic>Curcuma wenyujin</italic> Linn. (Zingiberaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Combination treatment with 4 Gy X-ray irradiation enhanced single and double strand DNA break and inhibited DNA repair system in human lung adenocarcinoma cell line (A549), induced apoptosis through up-regulation of p53 and downregulation of Bcl-2 protein (Li et al., <xref ref-type="bibr" rid="B92">2011</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Ellagic acid</bold>/<italic>Punica granatum</italic> Linn. (Lythraceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Suppressed inflammation and photoageing associated with chronic UV-B exposure by diminishing IL-1β and IL-6 production, and blocked infiltration of macrophages in the integuments of SKH-1 hairless mice (Bae et al., <xref ref-type="bibr" rid="B14">2010</xref>); enhanced radiosensitivity by increased superoxide generation, upregulated p53 protein expression, decreased antioxidant enzyme level, enhanced capase-3 activity, increased intracellular calcium levels, phospholipase C, and a drop in mitochondrial potential in HeLa cells (Bhosle et al., <xref ref-type="bibr" rid="B20">2010</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Epigallocatechin-gallates</bold>/<italic>Camellia sinensis</italic> L. (Kuntze) (Theaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Protected against UV-B-induced apoptosis via oxidative stress and JNK1/c-Jun pathway in retinal pigment epithelium cells (Cao et al., <xref ref-type="bibr" rid="B23">2012</xref>); protected liver tissue against the mobile phone-like radiofrequency-induced oxidative damage by enhancing antioxidant enzyme activities (Ozgur et al., <xref ref-type="bibr" rid="B114">2010</xref>); protected dendritic cells following UV-B irradiation by modulating IL-10 and IL-12 level (Jin et al., <xref ref-type="bibr" rid="B66">2009</xref>); exhibited radio-protection in mice following γ-radiation (Lee et al., <xref ref-type="bibr" rid="B86">2008a</xref>); combined treatment with low dose ionizing radiation, induced cells death in human brain endothelial cells (McLaughlin et al., <xref ref-type="bibr" rid="B101">2006</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Ferulic acid</bold>/Ubiquitous in dietary plants and fruit seeds</td><td valign="top" align="left" rowspan="1" colspan="1">Suppressive effect on UV-B radiation-induced matrix metalloproteinases MMP-2 and -9 expression in mouse skin, mediated via the proteasome pathway (Staniforth et al., <xref ref-type="bibr" rid="B149">2011</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Flavopiridol</bold>/<italic>Dysoxylum binectariferum</italic> (Roxb.) Hook (Meliaceae)/<italic>Amoora</italic><italic>rohituka</italic> (Meliaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Increased radiation sensitivity of GL261 murine glioma model (Newcomb et al., <xref ref-type="bibr" rid="B109">2006</xref>); improved radiation responses of esophageal adenocarcinoma cell and xenografts by targeting cyclin-dependent kinases (Raju et al., <xref ref-type="bibr" rid="B124">2006</xref>); combination treatment with radiation exhibited potential to conquer the radioresistance of human glioma cell line by inducing genetic alteration of p53 or bcl-2 (Hara et al., <xref ref-type="bibr" rid="B50">2008</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Genistein; Daidzein</bold>/ – Soy isoflavones and metabolites from <italic>Glycine max</italic> Linn. (Merr.) (Fabaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Showed radiosensitization via inhibition of NF-κB, altered cyclin B and/or p21WAF1/Cip1 expression, and G2/M arrest in prostate cancer cells; combination with radiation showed enhanced control on primary tumor growth in orthotopic metastatic mouse model; increased cytotoxicity correlated with inhibition of Bcl-xL and survivin, and upregulation of Bax and PARP cleavage in prostate cancer cell line; (Raffoul et al., <xref ref-type="bibr" rid="B123">2006</xref>, <xref ref-type="bibr" rid="B122">2007</xref>); sensitized apoptotic effect of γ-irradiation in CaSki cervical cancer cells via increased expression of p53, p21, and Cdc2-tyr-15-p, supporting the occurrence of G2/M arrest (Shin et al., <xref ref-type="bibr" rid="B141">2008</xref>); showed radiosensitizing effect through cell growth inhibition by modulating APE1/Ref-1, NF-κB, and HIF-1α level in prostate cancer cell lines (Singh-Gupta et al., <xref ref-type="bibr" rid="B144">2010</xref>); protected UV-B-induced senescence-like characteristics in human dermal fibroblasts via maintenance of antioxidant enzyme activities and modulation of mitochondrial oxidative stress through down-regulation of p66Shc-dependent signaling pathway (Wang et al., <xref ref-type="bibr" rid="B161">2010</xref>); prevented formation of excess radiation-induced centrosomes via p21 up-regulation in human U2OS and mouse NIH3T3 cells (Shimada et al., <xref ref-type="bibr" rid="B140">2011</xref>); mitigated radiation-induced lung injury in combination with EUK-207 in rat model (Mahmood et al., <xref ref-type="bibr" rid="B97">2011</xref>). 7,3′,4′-trihydroxyisoflavone, a major metabolite of daidzein, suppressed the incidence and multiplicity of UV-B-induced tumors in hairless mouse skin, and inhibited UV-B-induced COX-2 expression through the inhibition of NF-κB transcription activity in mouse skin epidermal JB6 P+cells (Lee et al., <xref ref-type="bibr" rid="B85">2011</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Honokiol</bold>/<italic>Magnolia</italic> spp. (Magnoliaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Liposomal encapsulation of the honokiol showed radiosensitizing activity (5 Gy) in Lewis lung carcinoma cells (LL/2) through induction of apoptosis and angiogenesis suppression (Hu et al., <xref ref-type="bibr" rid="B55">2008</xref>); reduced UV-B-induced skin cancer through caspase-3, caspase-8, caspase-9, poly (ADP-ribose) polymerase (PARP), and p53 activation leading to the induction of DNA fragmentation and apoptosis (Chilampalli et al., <xref ref-type="bibr" rid="B26">2010</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>β-Lapachone</bold>/<italic>Tabebuia rosea</italic> Bertol. (Bignoniaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Synergistic interaction with radiation induce toxicity in DU-145 human prostate cancer cells <italic>in vitro</italic> through elevating NAD(P)H:quinone oxidoreductase 1 (NQO1) activity and by inhibiting sub-lethal radiation damage repair (Suzuki et al., <xref ref-type="bibr" rid="B152">2006</xref>); intravenous injection of Au-nanoparticle containing β-lapachone exhibited enhanced efficacy in mice bearing xenograft human tumors (Jeong et al., <xref ref-type="bibr" rid="B65">2009</xref>); suppressed radiation-induced (4 Gy) activation of NF-κB, bcl-2, gadd45β, and cyclinD1 in A549 human lung cancer cell lines (Dong et al., <xref ref-type="bibr" rid="B33">2010a</xref>); combination with IR in NQO1(+) prostate cancer cells significantly elevated SSB level and γ-H2AX foci formation, caused poly(ADP-Ribose) polymerase-1 hyperactivation, and induction of μ-calpain-induced programmed cell death (Dong et al., <xref ref-type="bibr" rid="B34">2010b</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Maytansine (Maytansinol isobutyrate)</bold>/<italic>Maytenus</italic> spp. (Celastraceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Enhanced the effect of radiation in <italic>Drosophila</italic> and in human cancer cells by microtubule depolymerization and p53 dependent pathway (Edwards et al., <xref ref-type="bibr" rid="B38">2011</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Oleuropein</bold>/<italic>Olea europaea</italic> Linn. (Oleaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Prevented UV-B-induced skin damage in hairless mice by inhibiting the expression of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-13, vascular endothelial growth factor (VEGF), and cyclooxygenase-2 (COX-2) in the skin; histological evaluation showed suppression of Ki-67 and CD31-positive cells expression induced by irradiation (Kimura and Sumiyoshi, <xref ref-type="bibr" rid="B77">2009</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Plumbagin</bold>/<italic>Plumbago zeylanica</italic> Linn. (Plumbaginaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Showed radiosensitization effect through apoptosis in human cervical cancer cells (Nair et al., <xref ref-type="bibr" rid="B107">2008</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Resveratrol</bold>/<italic>Vitis</italic> spp. (Vitaceae); <italic>Vaccinium</italic> spp. (Ericaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Showed protective effect on UV-A and UV-B-induced damage in HaCaT cells by enhancing SOD, GSH-Px activity, reducing intracellular ROS generation and expression of caspase-3 and 8 proteins (Chen et al., <xref ref-type="bibr" rid="B25">2006</xref>; Park and Lee, <xref ref-type="bibr" rid="B118">2008</xref>); sensitized DU-145 to ionizing radiation by potentiating radiation-induced ceramide accumulation, through promoting its <italic>de novo</italic> biosynthesis (Scarlatti et al., <xref ref-type="bibr" rid="B135">2007</xref>); reduced radiation-induced chromosome aberration in mouse bone marrow cells (Carsten et al., <xref ref-type="bibr" rid="B24">2008</xref>); combination with γ-radiation inhibited NF-κB-dependent transcription, suppressed cFLIP and Bcl-xL expression, activated MAPK- and ATM-Chk2-p53 pathways, upregulated TRAIL promoter activity, and TRAIL surface expression in melanoma cell lines (Johnson et al., <xref ref-type="bibr" rid="B69">2008</xref>); increased radiosensitivity and induced apoptosis in CD133-positive cells derived from atypical teratoid/rhabdoid tumor (Kao et al., <xref ref-type="bibr" rid="B72">2009</xref>); sensitized A431 human epidermoid carcinoma cells to UV-B-induced cell death through disrupting NF-κB pathway by blocking phosphorylation of serine 536 and degradation of IκBα; decreased the phosphorylation of tyrosine 701, inhibited translocation of phospho-STAT1 to nucleus and suppressed metastatic LIMK1 protein (Roy et al., <xref ref-type="bibr" rid="B131">2009</xref>); Suppressed tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 pathway (Yang et al., <xref ref-type="bibr" rid="B167">2011</xref>); protected human keratinocytes HaCaT cells from UV-A-induced oxidative stress damage by down-regulating Keap1 expression (Liu et al., <xref ref-type="bibr" rid="B94">2011</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>α-Santalol</bold>/<italic>Santalum</italic><italic>album</italic> Linn. (Santalaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Prevented UV-B-induced skin cancer development by increasing in apoptosis proteins, caspase-3 and -8 levels and tumor suppressor protein, p53 in CD-1, SENCAR, and SKH-1 mice (Arasada et al., <xref ref-type="bibr" rid="B10">2008</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Silymarin</bold>/<italic>Silybum marianum</italic> (L.) Gaertn. (Asteraceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Caused decrease in E2F2 and E2F3 accompanied by reduced levels of p53, cyclin-dependent kinases, cyclins, CDC25C, mitogen activated protein kinases, Akt signaling, and subsequent inhibition of cell proliferation on skin, 15 and 25 weeks after UV-B exposure (Gu et al., <xref ref-type="bibr" rid="B44">2006</xref>); inhibited UV-B-induced photocarcinogenesis in mice through reduction of IL-10 and enhancement of IL-12 level (Meeran et al., <xref ref-type="bibr" rid="B102">2006</xref>); protected A375-S2 cell against UV-induced apoptosis was partially through SIRT1 pathway and modulation of the cell cycle distribution (Li et al., <xref ref-type="bibr" rid="B91">2007</xref>); attenuated UV-A-induced damage to human keratinocytes (Svobodová et al., <xref ref-type="bibr" rid="B153">2007</xref>); inhibited UV-induced oxidative stress through targeting infiltrating CD11b + cells in mouse skin (Katiyar et al., <xref ref-type="bibr" rid="B75">2008</xref>); prevented X-ray induced formation of DNA single-strand breaks (Fu et al., <xref ref-type="bibr" rid="B40">2010</xref>; Vaid and Katiyar, <xref ref-type="bibr" rid="B157">2010</xref>); inhibited UV-B radiation-induced DNA damage as demonstrated by reducing cyclobutane pyrimidine dimmers formation and induction of nucleotide excision repair leading to reduced apoptosis of normal human epidermal keratinocytes (Katiyar et al., <xref ref-type="bibr" rid="B74">2011</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Tangeritin</bold>/(citrus fruits)</td><td valign="top" align="left" rowspan="1" colspan="1">Reduced UV-B-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking mitogen activated protein kinase (MAPK) activation and reactive oxygen species generation (Yoon et al., <xref ref-type="bibr" rid="B168">2011</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Withaferin A</bold>/<italic>Withania somnifera</italic> L. (Dunal) (Solanaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Augmented x-ray induced cell death in chicken B lymphocyte (Uma Devi et al., <xref ref-type="bibr" rid="B156">2008</xref>); combination with fractionated regimen of radiation showed delayed proliferation of melanoma (Kalthur and Pathirissery, <xref ref-type="bibr" rid="B70">2010</xref>); increased the radiation-induced apoptosis in Caki cells through ROS generation, down-regulation of Bcl-2, and Akt dephosphorylation (Yang et al., <xref ref-type="bibr" rid="B165">2011a</xref>); enhanced IR-induced apoptosis associated with PARP cleavage, caspase-3 activation, down-regulation of anti-apoptotic protein Bcl-2 in human lymphoma U-937 cell line (Yang et al., <xref ref-type="bibr" rid="B166">2011b</xref>)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Zingerone</bold>/<italic>Zingiber officinale</italic> Roscoe (Zingiberaceae)</td><td valign="top" align="left" rowspan="1" colspan="1">Radiomodifying and anticlastogenic effect on Swiss albino mice (Rao et al., <xref ref-type="bibr" rid="B125">2011</xref>); antagonistic effects against radiation-induced cytotoxicity, genotoxicity, apoptosis, and oxidative stress in Chinese hamster lung fibroblast cells (Rao and Rao, <xref ref-type="bibr" rid="B126">2010a</xref>); act as radioprotectant by significantly reducing micronuclei formation, DNA damage, generation of reactive oxygen species and percentage of apoptotic cells induced by 2 Gy γ-radiation in human lymphocyte cells (Rao et al., <xref ref-type="bibr" rid="B127">2009</xref>)</td></tr></tbody></table></table-wrap><p>In Table <xref ref-type="table" rid="T1">1</xref>, we have enlisted the reports on the crude extracts/semi-purified fractions of plant samples which demonstrated substantial prospect to enhance the clinical success of radiotherapy through a combination treatment. It is to be noted that 14 out of the twenty six plants in this list, viz. <italic>Aloe arborescens</italic>, <italic>Angelica sinensis</italic>, <italic>Azadirachta indica</italic>, <italic>Biophytum sensitivum</italic>, <italic>Boerhaavia diffusa</italic>, <italic>Citrus sinensis</italic>, <italic>Genista sessilifolia</italic>, <italic>Grewia asiatica</italic>, <italic>Isatis indigotica</italic>, <italic>Moringa oleifera</italic>, <italic>Olea europaea</italic>, <italic>Rosmarinus officinalis</italic>, <italic>Rubus</italic> spp., and <italic>Xylopia aethiopica</italic> have not been investigated prior to 2006. Most of the reports were obtained from the <italic>in vivo</italic> study on mouse models, where the radio-protecting activity was found to be associated with significant scavenging of free radicals, and depletion in lipid peroxidation with elevation in the glutathione, catalase, and lactate dehydrogenase enzyme levels. Also, several of these studies were conducted on propagatory cell lines and primary cultures to unravel the underlying mode of action at the molecular level (Table <xref ref-type="table" rid="T1">1</xref>; Kimura and Sumiyoshi, <xref ref-type="bibr" rid="B77">2009</xref>; Lee et al., <xref ref-type="bibr" rid="B90">2010</xref>; Park et al., <xref ref-type="bibr" rid="B116">2011</xref>).</p><p>In Table <xref ref-type="table" rid="T2">2</xref>, we have presented the pure plant constituents and/or their analogs which could be considered as emerging candidates to be developed for the aforesaid application in future. Here, it is to be noted that the radiotherapeutic prospect of several plant-derived compounds, viz. allicin, betulinic acid, crocetin, diospyrin, honokiol, maytansine, oleuropein, α-santalol, tangeritin, withaferin A, and zingerone have been reported for the first time during the last 5 years.</p><p>Here, in Table <xref ref-type="table" rid="T2">2</xref>, it has to be mentioned that we have not included the established plant-derived anticancer drugs, viz. etoposide, pactitaxel, and <italic>Vinca</italic> alkaloids, which have not only been recognized as potential radiosensitizers, but already under clinical application in association with cancer radiotherapy (Burris and Hurtig, <xref ref-type="bibr" rid="B22">2010</xref>). Nevertheless, these drugs and their analogs are also under continuous appraisal for further development in this regard (Hiro et al., <xref ref-type="bibr" rid="B54">2010</xref>; Orditura et al., <xref ref-type="bibr" rid="B113">2010</xref>; Lillo et al., <xref ref-type="bibr" rid="B93">2011</xref>; Schwarzenberger et al., <xref ref-type="bibr" rid="B136">2011</xref>).</p><p>Again, prospective radiotherapeutic application of herbal formulations composed of traditional medicinal plants, and marketed as Triphala, Abana, Mentat, Septilin, Chyavanaprasha, Oligonol, HemoHIM, Fuzheng zengxiao formula, etc., have been reported by Sandhya et al. (<xref ref-type="bibr" rid="B133">2006</xref>), Jagetia (<xref ref-type="bibr" rid="B59">2007</xref>), Kundu et al. (<xref ref-type="bibr" rid="B83">2008</xref>), Park et al. (<xref ref-type="bibr" rid="B117">2010</xref>), Huang et al. (<xref ref-type="bibr" rid="B57">2011</xref>). In fact, the potent radioprotective property of Triphala, a mixture of three plants, might actually be attributed to the presence of <italic>Emblica officinalis</italic> (vide Table <xref ref-type="table" rid="T1">1</xref>), which is also a major constituent of some of the other Oriental rejuvenators (Chyavanaprasha, Septilin, etc.) found to offer protection against radiation damage. Likewise, some herbal products, like HemoHIM from Far-East countries, contain rhizhomes of <italic>Angelica</italic> spp., a prospective source of radioprotectants (vide Table <xref ref-type="table" rid="T1">1</xref>), while Oligonol is composed of modified plant phenolics. Therefore, these commercial formulations comprising poly-herbal mixtures have been kept outside the purview of the present article in order to focus on the search for new plants and phytochemicals with prospective radiotherapeutic property, and not included in our Tables.</p></sec><sec><title>Molecular Mechanism of Natural Radioprotectors/Radiosensitizers</title><p>Over the years, multi-modal therapy involving more than one anticancer agent applied in combination has been found to be favorable in the management of cancer. The precise efficacy and degree of tumor control exhibited by combination regimen, however, remains variable. Although the reasons for variability remain unclear, discovery of additional novel drugs that synergize with an existing radiation therapy would allow multiple combinations to choose from, thereby increasing the likelihood of clinical success. Recently, Edwards et al. (<xref ref-type="bibr" rid="B38">2011</xref>) has developed an interesting <italic>Drosophila</italic> larvae model which could be used to screen and identify molecules that would act in conjunction with radiation therapy (Edwards et al., <xref ref-type="bibr" rid="B38">2011</xref>). On the whole, a number of phytochemicals with anti-/pro-oxidant, or immunomodulatory activity hold greater promise in pre-clinical/clinical trials. Emerging data also demonstrated that many phytochemicals, especially camptothecin, epigallocatechin gallate (EGCG), paclitaxel, etoposide, curcumin, etc., have potent growth inhibitory and apoptosis inducing effects on human as well as animal cancer cells by targeting multiple cellular signaling pathways <italic>in vitro</italic>. Therefore, these compounds could be useful in combination with conventional chemotherapeutic agents/radiation for the treatment of cancer, and expected to have lower toxicity but higher effectiveness. Also, recent <italic>in vivo</italic> pre-clinical studies and clinical trials have provided increasing evidence in support of multi-targeted therapies in combination with natural products. A comprehensive view on the molecular mechanisms to rationalize the prospective role of such phytochemicals acting on relevant signaling pathways has been given in Table <xref ref-type="table" rid="T2">2</xref>.</p><sec><title>Scavenging of reactive oxygen species</title><p>Natural products in conjunction with irradiation are likely to exert the protective action through several mechanisms. Scavenging of free radicals generated during radiolysis would be a credible mode of action. Hence, naturally occurring polyphenolic compounds and antioxidant vitamins, primarily retinoids, would be the plausible candidates to offer radio-protection. It is a fact that the chances of developing cancer could be minimized through optimum nutritional supplementation by consuming a variety of fruits and vegetables, some of which have displayed chemopreventive activity by inhibiting tumorigenesis induced by chemical carcinogens and other genotoxic agents (Loo, <xref ref-type="bibr" rid="B95">2003</xref>).</p><p>However, clinical reports on application of plant extracts with antioxidant property as adjuvants in cancer radiotherapy are still sparse in literature. Apparently, there is an apprehension that the antioxidants would protect not only the normal cells, but also the tumors, from the attack of free radicals generated during the course of treatment with ionizing radiation and anticancer agents. The lack of strong experimental evidences to address this concern resulted in poor enthusiasm from radiation oncologists to recommend their patients to consume such antioxidant products during the course of therapy. However, the pros and cons of this aspect have been critically reviewed, based on <italic>in vitro</italic> and <italic>in vivo</italic> experimentations (Prasad, <xref ref-type="bibr" rid="B120">2005</xref>; Prasad and Cole, <xref ref-type="bibr" rid="B121">2006</xref>).</p><p>In this context, hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) has been known to play a crucial role in the proliferation of cancer cells. In fact, many human cancers, like melanoma, neuroblastoma, colon carcinoma, and ovarian carcinoma, were found to constitutively generate a high amount of H<sub>2</sub>O<sub>2</sub> (Szatrowski and Nathan, <xref ref-type="bibr" rid="B154">1991</xref>). This indicated that the tumor cells would require a certain level of oxidative stress for maintaining a balance to undergo either proliferation or apoptotic death, and a minor fluctuation in the concentration of ROS might be critical to the intracellular signaling mechanism (Droge, <xref ref-type="bibr" rid="B35">2002</xref>). The production of a larger amount of H<sub>2</sub>O<sub>2</sub> was demonstrated by transforming NIH3T3 cells with Ras oncogene to cancer cells (Benhar et al., <xref ref-type="bibr" rid="B18">2001</xref>), and a similar observation was noted in our laboratory when thymus cells in mice were transformed to thymic lymphoma after whole body radiation exposure (Pandey et al., unpublished data). The elevated production of ROS in cancer cells might be routed through mitochondrial electron transport chain, peroxisomes or NAD(P)H oxidase pathways, but the involvement of some direct mechanism of H<sub>2</sub>O<sub>2</sub> generation may also be suggested. The constitutive production of ROS caused sub-lethal DNA damage in tumors, which was evidenced by a higher level of 8-hydroxy-2′-deoxyguanosine, while the increase of 4-hydroxy-2-non-enal, the lipid peroxidation product, indicated damage in cell membrane of carcinoma tissues (Toyokuni et al., <xref ref-type="bibr" rid="B155">1995</xref>; Kondo et al., <xref ref-type="bibr" rid="B80">1999</xref>). The cancer cells, in spite of having some amount of sub-lethal DNA damage, are generally adapted to survive in such stress conditions, and do not undergo cell cycle arrest or apoptosis (Elledge and Lee, <xref ref-type="bibr" rid="B39">1995</xref>). In fact, at the basal level, the ROS would provide a stimulatory environment conducive to the proliferation of cancer cells, and become somewhat vital to their survival, rather than being merely useless cytotoxic products. Therefore, it may be hypothesized that the phenolic compounds with antioxidant properties could induce cell cycle arrest and apoptosis through scavenging of H<sub>2</sub>O<sub>2</sub>, presumably by depriving the cancer cells of an essential factor vital to their sustenance. It could also be speculated that a relatively lower level of constitutive ROS in normal cells would make them less vulnerable to the phenolic antioxidants (Simone et al., <xref ref-type="bibr" rid="B143">2007</xref>).</p></sec><sec><title>Generation of reactive oxygen species</title><p>Another category of phytochemicals showing antitumor activity are those which would enhance the generation of ROS, instead of scavenging the cellular free radicals. Such ROS-generators would apparently sensitize cancer cells endowed with persistent oxidative stress to undergo apoptotic death. We have already discussed about the critical maintenance of constitutively produced ROS, which is probably just below the threshold level required to induce apoptosis in tumors, the basal level being much lower in case of normal cells (Droge, <xref ref-type="bibr" rid="B35">2002</xref>). Therefore, ROS-generating quinones could presumably create the requisite imbalance to lead the tumors cells, rather than the normal ones, to apoptotic death. Thus, the pro-oxidant quinones like β-lapachone (Suzuki et al., <xref ref-type="bibr" rid="B152">2006</xref>; Dong et al., <xref ref-type="bibr" rid="B33">2010a</xref>,<xref ref-type="bibr" rid="B34">b</xref>), plumbagin (Nair et al., <xref ref-type="bibr" rid="B107">2008</xref>), and diospyrin derivatives (Hazra et al., <xref ref-type="bibr" rid="B53">2007</xref>; Kumar et al., <xref ref-type="bibr" rid="B81">2007</xref>, <xref ref-type="bibr" rid="B82">2008</xref>) have been found to induce apoptosis in tumor cells through DNA damage, lipid peroxidation, mitochondrial membrane depolarization, and related signaling events. Incidentally, a few other anticancer plant products, such as paclitaxel, vinca alkaloids, and maytansinol, have been found to enhance the effect of radiation in human cancer cells through the involvement of microtubule interference to inhibit the proliferation of tumor (Edwards et al., <xref ref-type="bibr" rid="B38">2011</xref>).</p></sec><sec><title>Induction of apoptotic pathway</title><p>Further, the phytochemicals could also interact directly with molecular pathways involving kinase networks, like mitogen activated protein kinases (MAPK), phosphatidylinositol-3-kinase (PI-3K), etc., thereby showing the potential to inhibit tumor growth in combination with anticancer drugs and radiation therapy by inducing programmed cell death or apoptosis (Garg et al., <xref ref-type="bibr" rid="B41">2005</xref>).</p><p>Again, the higher level of ROS could result in the increase in protein tyrosine kinase (PTK)-mediated phosphorylation of epidermal growth factor receptor (EGF-R; Kamata et al., <xref ref-type="bibr" rid="B71">2000</xref>), sequentially activating the Ras- and MAPK-signaling pathways (Loo, <xref ref-type="bibr" rid="B95">2003</xref>). Further, the over-activated MAPK would trigger expression of transcription factors, like nuclear factor kappa B (NF-κB), activator protein-1 (AP-1), and c-myc (a proto-oncoprotein; Meyer et al., <xref ref-type="bibr" rid="B103">1994</xref>; Muller et al., <xref ref-type="bibr" rid="B105">1997</xref>). It is to be noted that these transcription factors by themselves are redox-sensitive (Meyer et al., <xref ref-type="bibr" rid="B103">1994</xref>; Muller et al., <xref ref-type="bibr" rid="B105">1997</xref>; Loo, <xref ref-type="bibr" rid="B95">2003</xref>), and may be regulated directly by the higher level of ROS.</p><p>The molecular mechanism of anticancer property of plant-derived polyphenolic compounds, such as EGCG, resveratrol, quercetin, genistein, etc., has been primarily attributable to their ability to scavenge the constitutively expressed endogenous redox modulators (H<sub>2</sub>O<sub>2</sub>/OH<sup>.</sup>). Further studies revealed that EGCG inhibited the phosphorylation of MAPK-enzymes, viz. ERK (extracellular signal regulated kinases), JNK (c-Jun N-terminal kinases), and p38-MAPK (p38 mitogen activated protein kinases), activated by UV-B radiation in human epidermal keratinocytes (Katiyar et al., <xref ref-type="bibr" rid="B73">2001</xref>). Similar observation was obtained in UV-C-irradiated HeLa cells, pretreated with resveratrol, a polyphenolic constituent present in grapes and berries (Yu et al., <xref ref-type="bibr" rid="B171">2001</xref>). Resveratrol was also found to check NF-κB activation induced by tumor necrosis factor (TNF) in U-937, Jurkat, HeLa, and H4 glioma cells <italic>in vitro</italic> (Manna et al., <xref ref-type="bibr" rid="B99">2000</xref>). A few other plant phenolics, such as quercetin and genistein, have been reported to initiate apoptosis in pancreatic carcinoma cells, by inducing mitochondrial depolarization, cytochrome c release, and activation of caspases (Mouria et al., <xref ref-type="bibr" rid="B104">2002</xref>).</p><p>In our laboratory, we are investigating the radiomodulating potential of a diethtylether derivative (D7) of diospyrin, an antitumor quinonoid plant-product, in human breast carcinoma cells (MCF-7). It was observed that D7, in combination with radiation, could increase the apoptosis in tumor cells through down-regulation of the anti-apoptotic Bcl-2 and COX-2 gene expression, and up-regulation of pro-apoptotic genes, like p53 and p21. The higher expression of PUMA (p53 upregulated modulator of apoptosis), a pro-apoptotic protein, was also observed in the combination treatment. Further, the up-regulation of p21 expression in irradiated MCF-7 cells was found to be concomitant with the cell cycle arrest in the G1 phase (Kumar et al., <xref ref-type="bibr" rid="B81">2007</xref>). Further studies in mouse and human fibrosarcoma cells (viz., Wehi164 and HT1080, respectively) showed marked enhancement of cytotoxicity with decreased clonogenic survival following treatment with D7 in combination with radiation. Moreover, increased radiosensitivity of tumor cells by D7 was found to occur through inhibition of radiation-induced NF-κB activation with substantial generation of intracellular ROS, ultimately leading to programmed cell death. Further, a combination regimen of D7 with 5 Gy radiation administered in two fractionated doses (2.5 Gy each) could cause a significant inhibition of tumor growth and increased life span of experimental mice bringing the liver enzyme activity to the normal level (Kumar et al., <xref ref-type="bibr" rid="B82">2008</xref>).</p></sec></sec><sec><title>Conclusion</title><p>Cancer patients need to go through extensive treatment involving chemotherapy, surgical intervention, recurring exposure to gamma-irradiation, or a combination therapy. Some traditionally popular medicinal plants have recently gained attention for their ability to modulate a number of signaling pathways that could initiate and facilitate the proliferation of cancer. In many cases, the potency of these compounds/formulations to sensitize the cancer cells to radiotherapy could be corroborated with the inhibition/activation of the relevant molecular markers. However, the literature citations on supporting clinical trials showing similar observations are quite limited. Nevertheless, a number of reports are available on antioxidants being able to protect against radiation-induced oncogenic transformations in experimental systems. Based on these information it has been presumed that supplementation of vitamins in a good measure, and intake of health promoting plant products in the diet might reduce the harmful side effects of standard therapeutic modalities and enhance their selective toxicity toward malignant cells, leading to an overall improvement in the efficacy of anticancer treatment.</p><p>Furthermore, the underlying mechanism of survival and proliferation in some types of cancer would reveal the inherent dependence of these cells on their constitutive oxidative stress. This mechanistic interpretation, in the light of the well-studied role of plant-polyphenolics in scavenging cellular free radical species, might resolve the prevailing dilemma on whether antioxidants would provide the desirable relief, to some extent, to the normal cells in preference to the tumor-bearing ones. Again, this hypothesis would be relevant to the radiosensitizing effect exhibited by a few ROS-generating antitumor agents as well. Thus, it is hoped that future research would add up positively, and would bring more of the aforesaid phytochemicals from “bench to bedside” of the suffering humanity seeking relief from the awful maladies of cancer.</p></sec><sec><title>Conflict of Interest Statement</title><p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p></sec></body><back><ack><p>Banasri Hazra is grateful to the Board of Radiation and Nuclear Sciences, Department of Atomic Energy, Mumbai (Grant No. 2008/37/30/BRNS), and the University Grants Commission, New Delhi, for financial support. Subhalakshmi Ghosh is a Research Associate under this program.</p></ack><ref-list><title>References</title><ref id="B1"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Adaramoye</surname><given-names>O. A.</given-names></name><name><surname>Adedara</surname><given-names>I. A.</given-names></name><name><surname>Popoola</surname><given-names>B.</given-names></name><name><surname>Farombi</surname><given-names>E. O.</given-names></name></person-group> (<year>2010a</year>). <article-title>Extract of <italic>Xylopia aethiopica</italic> (Annonaceae) protects against gamma-radiation induced testicular damage in Wistar rats</article-title>. <source>J. Basic. Clin. Physiol. Pharmacol.</source> <volume>21</volume>, <fpage>295</fpage>–<lpage>313</lpage><pub-id pub-id-type="doi">10.1515/JBCPP.2010.21.4.295</pub-id><pub-id pub-id-type="pmid">21305847</pub-id></mixed-citation></ref><ref id="B2"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Adaramoye</surname><given-names>O. A.</given-names></name><name><surname>Okiti</surname><given-names>O. O.</given-names></name><name><surname>Farombi</surname><given-names>E. O.</given-names></name></person-group> (<year>2011</year>). <article-title>Dried fruit extract from <italic>Xylopia aethiopica</italic> (Annonaceae) protects Wistar albino rats from adverse effects of whole body radiation</article-title>. <source>Exp. Toxicol. Pathol.</source> <volume>63</volume>, <fpage>635</fpage>–<lpage>643</lpage><pub-id pub-id-type="doi">10.1016/j.etp.2010.05.005</pub-id><pub-id pub-id-type="pmid">20570120</pub-id></mixed-citation></ref><ref id="B3"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Adaramoye</surname><given-names>O. A.</given-names></name><name><surname>Popoola</surname><given-names>B. O.</given-names></name><name><surname>Farombi</surname><given-names>E. O.</given-names></name></person-group> (<year>2010b</year>). <article-title>Effects of <italic>Xylopia aethiopica</italic> (Annonaceae) fruit methanol extract on gamma-radiation-induced oxidative stress in brain of adult male Wistar rats</article-title>. <source>Acta Biol. Hung.</source> <volume>61</volume>, <fpage>250</fpage>–<lpage>261</lpage><pub-id pub-id-type="doi">10.1556/ABiol.61.2010.3.2</pub-id><pub-id pub-id-type="pmid">20724272</pub-id></mixed-citation></ref><ref id="B4"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Adil</surname><given-names>M. D.</given-names></name><name><surname>Kaiser</surname><given-names>P.</given-names></name><name><surname>Satti</surname><given-names>N. K.</given-names></name><name><surname>Zargar</surname><given-names>A. M.</given-names></name><name><surname>Vishwakarma</surname><given-names>R. A.</given-names></name><name><surname>Tasduq</surname><given-names>S. A.</given-names></name></person-group> (<year>2010</year>). <article-title>Effect of <italic>Emblica officinalis</italic> (fruit) against UVB-induced photo-aging in human skin fibroblasts</article-title>. <source>J. Ethnopharmacol.</source> <volume>132</volume>, <fpage>109</fpage>–<lpage>114</lpage><pub-id pub-id-type="doi">10.1016/j.jep.2010.07.047</pub-id><pub-id pub-id-type="pmid">20688142</pub-id></mixed-citation></ref><ref id="B5"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Afaq</surname><given-names>F.</given-names></name><name><surname>Khan</surname><given-names>N.</given-names></name><name><surname>Syed</surname><given-names>D. N.</given-names></name><name><surname>Mukhtar</surname><given-names>H.</given-names></name></person-group> (<year>2010</year>). <article-title>Oral feeding of pomegranate fruit extract inhibits early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis</article-title>. <source>Photochem. Photobiol.</source> <volume>86</volume>, <fpage>1318</fpage>–<lpage>1326</lpage><pub-id pub-id-type="doi">10.1111/j.1751-1097.2010.00815.x</pub-id><pub-id pub-id-type="pmid">20946358</pub-id></mixed-citation></ref><ref id="B6"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Afaq</surname><given-names>F.</given-names></name><name><surname>Zaid</surname><given-names>M. A.</given-names></name><name><surname>Khan</surname><given-names>N.</given-names></name><name><surname>Dreher</surname><given-names>M.</given-names></name><name><surname>Mukhtar</surname><given-names>H.</given-names></name></person-group> (<year>2009</year>). <article-title>Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skin</article-title>. <source>Exp. Dermatol.</source> <volume>18</volume>, <fpage>553</fpage>–<lpage>561</lpage><pub-id pub-id-type="doi">10.1111/j.1600-0625.2008.00829.x</pub-id><pub-id pub-id-type="pmid">19320737</pub-id></mixed-citation></ref><ref id="B7"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Akpolat</surname><given-names>M.</given-names></name><name><surname>Kanter</surname><given-names>M.</given-names></name><name><surname>Uzal</surname><given-names>M. C.</given-names></name></person-group> (<year>2009</year>). <article-title>Protective effects of curcumin against gamma radiation-induced ileal mucosal damage</article-title>. <source>Arch. Toxicol.</source> <volume>83</volume>, <fpage>609</fpage>–<lpage>617</lpage><pub-id pub-id-type="doi">10.1007/s00204-008-0352-4</pub-id><pub-id pub-id-type="pmid">18754102</pub-id></mixed-citation></ref><ref id="B8"><mixed-citation publication-type="book"><collab>American Cancer Society.</collab> (<year>2007</year>). <source>Global Cancer Facts, and Figures 2007</source>. <publisher-loc>Atlanta, GA</publisher-loc>: <publisher-name>American Cancer Society</publisher-name></mixed-citation></ref><ref id="B9"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Amorino</surname><given-names>G. P.</given-names></name><name><surname>Mohr</surname><given-names>P. J.</given-names></name><name><surname>Hercules</surname><given-names>S. K.</given-names></name><name><surname>Pyo</surname><given-names>H.</given-names></name><name><surname>Choy</surname><given-names>H.</given-names></name></person-group> (<year>2000</year>). <article-title>Combined effects of the orally active cisplatin analog, JM216, and radiation in antitumor therapy</article-title>. <source>Cancer Chemother. Pharmacol.</source> <volume>46</volume>, <fpage>423</fpage>–<lpage>426</lpage><pub-id pub-id-type="doi">10.1007/s002800000169</pub-id><pub-id pub-id-type="pmid">11127948</pub-id></mixed-citation></ref><ref id="B10"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Arasada</surname><given-names>B. L.</given-names></name><name><surname>Bommareddy</surname><given-names>A.</given-names></name><name><surname>Zhang</surname><given-names>X.</given-names></name><name><surname>Bremmon</surname><given-names>K.</given-names></name><name><surname>Dwivedi</surname><given-names>C.</given-names></name></person-group> (<year>2008</year>). <article-title>Effects of alpha-santalol on proapoptotic caspases and p53 expression in UVB irradiated mouse skin</article-title>. <source>Anticancer Res.</source> <volume>28</volume>, <fpage>129</fpage>–<lpage>132</lpage><pub-id pub-id-type="pmid">18383835</pub-id></mixed-citation></ref><ref id="B11"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Aravindan</surname><given-names>N.</given-names></name><name><surname>Veeraraghavan</surname><given-names>J.</given-names></name><name><surname>Madhusoodhanan</surname><given-names>R.</given-names></name><name><surname>Herman</surname><given-names>T. S.</given-names></name><name><surname>Natarajan</surname><given-names>M.</given-names></name></person-group> (<year>2011</year>). <article-title>Curcumin regulates low-linear energy transfer γ-radiation-induced NFκB-dependent telomerase activity in human neuroblastoma cells</article-title>. <source>Int. J. Radiat. Oncol. Biol. Phys.</source> <volume>79</volume>, <fpage>1206</fpage>–<lpage>1215</lpage><pub-id pub-id-type="doi">10.1016/j.ijrobp.2010.10.058</pub-id><pub-id pub-id-type="pmid">21236599</pub-id></mixed-citation></ref><ref id="B12"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Arora</surname><given-names>R.</given-names></name><name><surname>Gupta</surname><given-names>D.</given-names></name><name><surname>Chawla</surname><given-names>R.</given-names></name><name><surname>Sagar</surname><given-names>R.</given-names></name><name><surname>Sharma</surname><given-names>A.</given-names></name><name><surname>Kumar</surname><given-names>R.</given-names></name></person-group> (<year>2005</year>). <article-title>Radioprotection by plant products: present status and future prospects</article-title>. <source>Phytother. Res.</source> <volume>19</volume>, <fpage>1</fpage>–<lpage>22</lpage><pub-id pub-id-type="doi">10.1002/ptr.1605</pub-id><pub-id pub-id-type="pmid">15799007</pub-id></mixed-citation></ref><ref id="B13"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bache</surname><given-names>M.</given-names></name><name><surname>Zschornak</surname><given-names>M. P.</given-names></name><name><surname>Passin</surname><given-names>S.</given-names></name><name><surname>Kessler</surname><given-names>J.</given-names></name><name><surname>Wichmann</surname><given-names>H.</given-names></name><name><surname>Kappler</surname><given-names>M.</given-names></name><name><surname>Paschke</surname><given-names>R.</given-names></name><name><surname>Kaluderovic</surname><given-names>G. N.</given-names></name><name><surname>Kommera</surname><given-names>H.</given-names></name><name><surname>Taubert</surname><given-names>H.</given-names></name><name><surname>Vordermark</surname><given-names>D.</given-names></name></person-group> (<year>2011</year>). <article-title>Increased betulinic acid induced cytotoxicity and radiosensitivity in glioma cells under hypoxic conditions</article-title>. <source>Radiat. Oncol.</source> <volume>6</volume>, <fpage>111</fpage><pub-id pub-id-type="doi">10.1186/1748-717X-6-111</pub-id><pub-id pub-id-type="pmid">21906280</pub-id></mixed-citation></ref><ref id="B14"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bae</surname><given-names>J. Y.</given-names></name><name><surname>Choi</surname><given-names>J. S.</given-names></name><name><surname>Kang</surname><given-names>S. W.</given-names></name><name><surname>Lee</surname><given-names>Y. J.</given-names></name><name><surname>Park</surname><given-names>J.</given-names></name><name><surname>Kang</surname><given-names>Y. H.</given-names></name></person-group> (<year>2010</year>). <article-title>Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UV-B irradiation</article-title>. <source>Exp. Dermatol.</source> <volume>19</volume>, <fpage>e182</fpage>–<lpage>e190</lpage><pub-id pub-id-type="doi">10.1111/j.1600-0625.2009.01044.x</pub-id><pub-id pub-id-type="pmid">20113347</pub-id></mixed-citation></ref><ref id="B15"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bakuridze</surname><given-names>A. D.</given-names></name><name><surname>Nikolaev</surname><given-names>S. M.</given-names></name><name><surname>Berashvili</surname><given-names>D. T.</given-names></name><name><surname>Bakuridze</surname><given-names>K. A.</given-names></name><name><surname>Tsomaia</surname><given-names>I. V.</given-names></name></person-group> (<year>2009</year>). <article-title>Radio protective drug production from fresh leaves of <italic>Aloe arborescens</italic> mill</article-title>. <source>Georgian Med. News</source> <volume>171</volume>, <fpage>80</fpage>–<lpage>83</lpage><pub-id pub-id-type="pmid">19578223</pub-id></mixed-citation></ref><ref id="B16"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baliga</surname><given-names>M. S.</given-names></name><name><surname>Bhat</surname><given-names>H. P.</given-names></name><name><surname>Pereira</surname><given-names>M. M.</given-names></name><name><surname>Mathias</surname><given-names>N.</given-names></name><name><surname>Venkatesh</surname><given-names>P.</given-names></name></person-group> (<year>2010</year>). <article-title>Radioprotective effects of <italic>Aegle marmelos</italic> (L.) Correa (Bael): a concise review</article-title>. <source>J. Altern. Complement. Med.</source> <volume>16</volume>, <fpage>1109</fpage>–<lpage>1116</lpage><pub-id pub-id-type="doi">10.1089/acm.2009.0633</pub-id><pub-id pub-id-type="pmid">20932194</pub-id></mixed-citation></ref><ref id="B17"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baliga</surname><given-names>M. S.</given-names></name><name><surname>Rao</surname><given-names>S.</given-names></name></person-group> (<year>2010</year>). <article-title>Radioprotective potential of mint: a brief review</article-title>. <source>J. Cancer. Res. Ther.</source> <volume>6</volume>, <fpage>255</fpage>–<lpage>262</lpage><pub-id pub-id-type="doi">10.4103/0973-1482.73336</pub-id><pub-id pub-id-type="pmid">21119249</pub-id></mixed-citation></ref><ref id="B18"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Benhar</surname><given-names>M.</given-names></name><name><surname>Dalyot</surname><given-names>I.</given-names></name><name><surname>Engelberg</surname><given-names>D.</given-names></name><name><surname>Levitzki</surname><given-names>A.</given-names></name></person-group> (<year>2001</year>). <article-title>Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress</article-title>. <source>Mol. Cell. Biol.</source> <volume>21</volume>, <fpage>6913</fpage>–<lpage>6926</lpage><pub-id pub-id-type="doi">10.1128/MCB.21.20.6913-6926.2001</pub-id><pub-id pub-id-type="pmid">11564875</pub-id></mixed-citation></ref><ref id="B19"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bensadoun</surname><given-names>R. J.</given-names></name><name><surname>Schubert</surname><given-names>M. M.</given-names></name><name><surname>Lalla</surname><given-names>R. V.</given-names></name><name><surname>Keefe</surname><given-names>D.</given-names></name></person-group> (<year>2006</year>). <article-title>Amifostine in the management of radiation-induced and chemo-induced mucositis</article-title>. <source>Support. Care Cancer</source> <volume>14</volume>, <fpage>566</fpage>–<lpage>572</lpage><pub-id pub-id-type="doi">10.1007/s00520-006-0047-4</pub-id><pub-id pub-id-type="pmid">16586122</pub-id></mixed-citation></ref><ref id="B20"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bhosle</surname><given-names>S. M.</given-names></name><name><surname>Ahire</surname><given-names>V. R.</given-names></name><name><surname>Henry</surname><given-names>M. S.</given-names></name><name><surname>Thakur</surname><given-names>V. S.</given-names></name><name><surname>Huilgol</surname><given-names>N. G.</given-names></name><name><surname>Mishra</surname><given-names>K. P.</given-names></name></person-group> (<year>2010</year>). <article-title>Augmentation of radiation-induced apoptosis by ellagic acid</article-title>. <source>Cancer Invest.</source> <volume>28</volume>, <fpage>323</fpage>–<lpage>330</lpage><pub-id pub-id-type="doi">10.3109/07357900902849616</pub-id><pub-id pub-id-type="pmid">19863348</pub-id></mixed-citation></ref><ref id="B21"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bray</surname><given-names>F.</given-names></name><name><surname>Moller</surname><given-names>B.</given-names></name></person-group> (<year>2006</year>). <article-title>Predicting the future burden of cancer</article-title>. <source>Nat. Rev. Cancer</source> <volume>6</volume>, <fpage>63</fpage>–<lpage>74</lpage><pub-id pub-id-type="doi">10.1038/nrc1781</pub-id><pub-id pub-id-type="pmid">16372017</pub-id></mixed-citation></ref><ref id="B22"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Burris</surname><given-names>H. A.</given-names></name><name><surname>Hurtig</surname><given-names>J.</given-names></name></person-group> (<year>2010</year>). <article-title>Radiation recall</article-title>. <source>Oncologist</source> <volume>15</volume>, <fpage>1227</fpage>–<lpage>1237</lpage><pub-id pub-id-type="doi">10.1634/theoncologist.2010-0006</pub-id><pub-id pub-id-type="pmid">21045191</pub-id></mixed-citation></ref><ref id="B23"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cao</surname><given-names>G.</given-names></name><name><surname>Chen</surname><given-names>M.</given-names></name><name><surname>Song</surname><given-names>Q.</given-names></name><name><surname>Liu</surname><given-names>Y.</given-names></name><name><surname>Xie</surname><given-names>L.</given-names></name><name><surname>Han</surname><given-names>Y.</given-names></name><name><surname>Liu</surname><given-names>Z.</given-names></name><name><surname>Ji</surname><given-names>Y.</given-names></name><name><surname>Jiang</surname><given-names>Q.</given-names></name></person-group> (<year>2012</year>). <article-title>EGCG protects against UVB-induced apoptosis via oxidative stress and the JNK1/c-Jun pathway in ARPE19 cells</article-title>. <source>Mol. Med. Report.</source> <volume>5</volume>, <fpage>54</fpage>–<lpage>59</lpage><pub-id pub-id-type="pmid">21909619</pub-id></mixed-citation></ref><ref id="B24"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Carsten</surname><given-names>R. E.</given-names></name><name><surname>Bachand</surname><given-names>A. M.</given-names></name><name><surname>Bailey</surname><given-names>S. M.</given-names></name><name><surname>Ullrich</surname><given-names>R. L.</given-names></name></person-group> (<year>2008</year>). <article-title>Resveratrol reduces radiation-induced chromosome aberration frequencies in mouse bone marrow cells</article-title>. <source>Radiat. Res.</source> <volume>169</volume>, <fpage>633</fpage>–<lpage>638</lpage><pub-id pub-id-type="doi">10.1667/RR1190.1</pub-id><pub-id pub-id-type="pmid">18494544</pub-id></mixed-citation></ref><ref id="B25"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chen</surname><given-names>M. L.</given-names></name><name><surname>Li</surname><given-names>J.</given-names></name><name><surname>Xiao</surname><given-names>W. R.</given-names></name><name><surname>Sun</surname><given-names>L.</given-names></name><name><surname>Tang</surname><given-names>H.</given-names></name><name><surname>Wang</surname><given-names>L.</given-names></name><name><surname>Wu</surname><given-names>L. Y.</given-names></name><name><surname>Chen</surname><given-names>X.</given-names></name><name><surname>Xie</surname><given-names>H. F.</given-names></name></person-group> (<year>2006</year>). <article-title>Protective effect of resveratrol against oxidative damage of UVA irradiated HaCaT cells</article-title>. <source>Zhong Nan Da Xue Xue Bao Yi Xue Ban</source> <volume>31</volume>, <fpage>635</fpage>–<lpage>639</lpage><pub-id pub-id-type="pmid">17062920</pub-id></mixed-citation></ref><ref id="B26"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chilampalli</surname><given-names>S.</given-names></name><name><surname>Zhang</surname><given-names>X.</given-names></name><name><surname>Fahmy</surname><given-names>H.</given-names></name><name><surname>Kaushik</surname><given-names>R. S.</given-names></name><name><surname>Zeman</surname><given-names>D.</given-names></name><name><surname>Hildreth</surname><given-names>M. B.</given-names></name><name><surname>Dwivedi</surname><given-names>C.</given-names></name></person-group> (<year>2010</year>). <article-title>Chemopreventive effects of honokiol on UVB-induced skin cancer development</article-title>. <source>Anticancer Res.</source> <volume>30</volume>, <fpage>777</fpage>–<lpage>783</lpage><pub-id pub-id-type="pmid">20392996</pub-id></mixed-citation></ref><ref id="B27"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Choy</surname><given-names>H.</given-names></name></person-group> (<year>2001</year>). <article-title>Taxanes in combined modality therapy for solid tumors</article-title>. <source>Crit. Rev. Oncol. Hematol.</source> <volume>37</volume>, <fpage>237</fpage>–<lpage>247</lpage><pub-id pub-id-type="doi">10.1016/S1040-8428(00)00112-8</pub-id><pub-id pub-id-type="pmid">11248579</pub-id></mixed-citation></ref><ref id="B28"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cimino</surname><given-names>F.</given-names></name><name><surname>Cristani</surname><given-names>M.</given-names></name><name><surname>Saija</surname><given-names>A.</given-names></name><name><surname>Bonina</surname><given-names>F. P.</given-names></name><name><surname>Virgili</surname><given-names>F.</given-names></name></person-group> (<year>2007</year>). <article-title>Protective effects of a red orange extract on UVB-induced damage in human keratinocytes</article-title>. <source>Biofactors</source> <volume>30</volume>, <fpage>129</fpage>–<lpage>138</lpage><pub-id pub-id-type="doi">10.1002/biof.5520300206</pub-id><pub-id pub-id-type="pmid">18356584</pub-id></mixed-citation></ref><ref id="B29"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Curry</surname><given-names>H. A.</given-names></name><name><surname>Curran</surname><given-names>W. J.</given-names></name></person-group> (<year>2003</year>). <article-title>“Chemoradiation strategies for patients with malignant gliomas,”</article-title> in <source>Chemoradiation in Cancer Therapy</source>, ed. <person-group person-group-type="editor"><name><surname>Choy</surname><given-names>H.</given-names></name></person-group> (<publisher-loc>Totowa, NJ</publisher-loc>: <publisher-name>Humana Press Inc.</publisher-name>), <fpage>129</fpage></mixed-citation></ref><ref id="B30"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>da Silva</surname><given-names>V. V.</given-names></name><name><surname>Ropke</surname><given-names>C. D.</given-names></name><name><surname>Miranda</surname><given-names>D. V.</given-names></name><name><surname>de Almeida</surname><given-names>R. L.</given-names></name><name><surname>Sawada</surname><given-names>T. C.</given-names></name><name><surname>Rivelli</surname><given-names>D. P.</given-names></name><name><surname>Barros</surname><given-names>S. B.</given-names></name></person-group> (<year>2009</year>). <article-title>Photoprotective effect of Pothomorphe umbellata on UVB radiation-induced biomarkers involved in carcinogenesis of hairless mouse epidermis</article-title>. <source>Cutan. Ocul. Toxicol.</source> <volume>28</volume>, <fpage>54</fpage>–<lpage>60</lpage><pub-id pub-id-type="doi">10.1080/15569520902784014</pub-id><pub-id pub-id-type="pmid">19263261</pub-id></mixed-citation></ref><ref id="B31"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dange</surname><given-names>P.</given-names></name><name><surname>Sarma</surname><given-names>H.</given-names></name><name><surname>Pandey</surname><given-names>B. N.</given-names></name><name><surname>Mishra</surname><given-names>K. P.</given-names></name></person-group> (<year>2007</year>). <article-title>Radiation-induced incidence of thymic lymphoma in mice and its prevention by antioxidants</article-title>. <source>J. Environ. Pathol. Toxicol. Oncol.</source> <volume>26</volume>, <fpage>273</fpage>–<lpage>279</lpage><pub-id pub-id-type="pmid">18197825</pub-id></mixed-citation></ref><ref id="B32"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dest</surname><given-names>V. M.</given-names></name></person-group> (<year>2006</year>). <article-title>Radioprotectants: adding quality of life to survivorship?</article-title> <source>Semin. Oncol. Nurs.</source> <volume>22</volume>, <fpage>249</fpage>–<lpage>256</lpage><pub-id pub-id-type="doi">10.1016/j.soncn.2006.07.009</pub-id><pub-id pub-id-type="pmid">17095401</pub-id></mixed-citation></ref><ref id="B33"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dong</surname><given-names>G. Z.</given-names></name><name><surname>Oh</surname><given-names>E. T.</given-names></name><name><surname>Lee</surname><given-names>H.</given-names></name><name><surname>Park</surname><given-names>M. T.</given-names></name><name><surname>Song</surname><given-names>C. W.</given-names></name><name><surname>Park</surname><given-names>H. J.</given-names></name></person-group> (<year>2010a</year>). <article-title>Beta-lapachone suppresses radiation-induced activation of nuclear factor-kappaB</article-title>. <source>Exp. Mol. Med.</source> <volume>42</volume>, <fpage>327</fpage>–<lpage>334</lpage><pub-id pub-id-type="doi">10.3858/emm.2010.42.5.034</pub-id><pub-id pub-id-type="pmid">20200474</pub-id></mixed-citation></ref><ref id="B34"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dong</surname><given-names>Y.</given-names></name><name><surname>Bey</surname><given-names>E. A.</given-names></name><name><surname>Li</surname><given-names>L. S.</given-names></name><name><surname>Kabbani</surname><given-names>W.</given-names></name><name><surname>Yan</surname><given-names>J.</given-names></name><name><surname>Xie</surname><given-names>X. J.</given-names></name><name><surname>Hsieh</surname><given-names>J. T.</given-names></name><name><surname>Gao</surname><given-names>J.</given-names></name><name><surname>Boothman</surname><given-names>D. A.</given-names></name></person-group> (<year>2010b</year>). <article-title>Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation</article-title>. <source>Cancer Res.</source> <volume>70</volume>, <fpage>8088</fpage>–<lpage>8096</lpage><pub-id pub-id-type="doi">10.1158/0008-5472.CAN-10-1418</pub-id><pub-id pub-id-type="pmid">20940411</pub-id></mixed-citation></ref><ref id="B35"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Droge</surname><given-names>W.</given-names></name></person-group> (<year>2002</year>). <article-title>Free radicals in the physiological control of cell function</article-title>. <source>Physiol. Rev.</source> <volume>82</volume>, <fpage>47</fpage>–<lpage>95</lpage><pub-id pub-id-type="pmid">11773609</pub-id></mixed-citation></ref><ref id="B36"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dujic</surname><given-names>J.</given-names></name><name><surname>Kippenberger</surname><given-names>S.</given-names></name><name><surname>Ramirez-Bosca</surname><given-names>A.</given-names></name><name><surname>Diaz-Alperi</surname><given-names>J.</given-names></name><name><surname>Bereiter-Hahn</surname><given-names>J.</given-names></name><name><surname>Kaufmann</surname><given-names>R.</given-names></name><name><surname>Bernd</surname><given-names>A.</given-names></name><name><surname>Hofmann</surname><given-names>M.</given-names></name></person-group> (<year>2009</year>). <article-title>Curcumin in combination with visible light inhibits tumor growth in a xenograft tumor model</article-title>. <source>Int. J. Cancer</source> <volume>124</volume>, <fpage>1422</fpage>–<lpage>1428</lpage><pub-id pub-id-type="doi">10.1002/ijc.23997</pub-id><pub-id pub-id-type="pmid">19035461</pub-id></mixed-citation></ref><ref id="B37"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Eder-Czembirek</surname><given-names>C.</given-names></name><name><surname>Erovic</surname><given-names>B. M.</given-names></name><name><surname>Czembirek</surname><given-names>C.</given-names></name><name><surname>Brunner</surname><given-names>M.</given-names></name><name><surname>Selzer</surname><given-names>E.</given-names></name><name><surname>Pötter</surname><given-names>R.</given-names></name><name><surname>Thurnher</surname><given-names>D.</given-names></name></person-group> (<year>2010</year>). <article-title>Betulinic acid a radiosensitizer in head and neck squamous cell carcinoma cell lines</article-title>. <source>Strahlenther. Onkol.</source> <volume>186</volume>, <fpage>143</fpage>–<lpage>148</lpage><pub-id pub-id-type="doi">10.1007/s00066-010-2069-6</pub-id><pub-id pub-id-type="pmid">20339825</pub-id></mixed-citation></ref><ref id="B38"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Edwards</surname><given-names>A.</given-names></name><name><surname>Gladstone</surname><given-names>M.</given-names></name><name><surname>Yoon</surname><given-names>P.</given-names></name><name><surname>Raben</surname><given-names>D.</given-names></name><name><surname>Frederick</surname><given-names>B.</given-names></name><name><surname>Su</surname><given-names>T. T.</given-names></name></person-group> (<year>2011</year>). <article-title>Combinatorial effect of maytansinol and radiation in <italic>Drosophila</italic> and human cancer cells</article-title>. <source>Dis. Models Mech.</source> <volume>4</volume>, <fpage>496</fpage>–<lpage>503</lpage><pub-id pub-id-type="doi">10.1242/dmm.006486</pub-id></mixed-citation></ref><ref id="B39"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Elledge</surname><given-names>R. M.</given-names></name><name><surname>Lee</surname><given-names>W. H.</given-names></name></person-group> (<year>1995</year>). <article-title>Life and death by p53</article-title>. <source>Bioessays</source> <volume>17</volume>, <fpage>923</fpage>–<lpage>930</lpage><pub-id pub-id-type="doi">10.1002/bies.950171105</pub-id><pub-id pub-id-type="pmid">8526886</pub-id></mixed-citation></ref><ref id="B40"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fu</surname><given-names>H.</given-names></name><name><surname>Lin</surname><given-names>M.</given-names></name><name><surname>Katsumura</surname><given-names>Y.</given-names></name><name><surname>Yokoya</surname><given-names>A.</given-names></name><name><surname>Hata</surname><given-names>K.</given-names></name><name><surname>Muroya</surname><given-names>Y.</given-names></name><name><surname>Fujii</surname><given-names>K.</given-names></name><name><surname>Shikazono</surname><given-names>N.</given-names></name></person-group> (<year>2010</year>). <article-title>Protective effects of silybin and analogues against X-ray radiation-induced damage</article-title>. <source>Acta Biochim. Biophys. Sin. (Shanghai)</source> <volume>42</volume>, <fpage>489</fpage>–<lpage>495</lpage><pub-id pub-id-type="doi">10.1093/abbs/gmq062</pub-id><pub-id pub-id-type="pmid">20705588</pub-id></mixed-citation></ref><ref id="B41"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Garg</surname><given-names>A. K.</given-names></name><name><surname>Buchholz</surname><given-names>T. A.</given-names></name><name><surname>Aggarwal</surname><given-names>B. B.</given-names></name></person-group> (<year>2005</year>). <article-title>Chemosensitization and radiosensitization of tumors by plant polyphenols</article-title>. <source>Antioxid. Redox Signal.</source> <volume>7</volume>, <fpage>1630</fpage>–<lpage>1647</lpage><pub-id pub-id-type="doi">10.1089/ars.2005.7.1630</pub-id><pub-id pub-id-type="pmid">16356126</pub-id></mixed-citation></ref><ref id="B42"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Girdhani</surname><given-names>S.</given-names></name><name><surname>Bhosle</surname><given-names>S. M.</given-names></name><name><surname>Thulasidas</surname><given-names>S. A.</given-names></name><name><surname>Kumar</surname><given-names>A.</given-names></name><name><surname>Mishra</surname><given-names>K. P.</given-names></name></person-group> (<year>2005</year>). <article-title>Potential of radio-sensitizing agents in cancer chemo-radiotherapy</article-title>. <source>J. Cancer Res. Ther.</source> <volume>1</volume>, <fpage>129</fpage>–<lpage>131</lpage><pub-id pub-id-type="doi">10.4103/0973-1482.19585</pub-id><pub-id pub-id-type="pmid">17998642</pub-id></mixed-citation></ref><ref id="B43"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Grdina</surname><given-names>D. J.</given-names></name><name><surname>Murley</surname><given-names>J. S.</given-names></name><name><surname>Kataoka</surname><given-names>Y.</given-names></name></person-group> (<year>2002</year>). <article-title>Radioprotectants: current status and new directions</article-title>. <source>Oncology</source> <volume>63</volume>, <fpage>2</fpage>–<lpage>10</lpage><pub-id pub-id-type="doi">10.1159/000067146</pub-id><pub-id pub-id-type="pmid">12466639</pub-id></mixed-citation></ref><ref id="B44"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gu</surname><given-names>M.</given-names></name><name><surname>Singh</surname><given-names>R. P.</given-names></name><name><surname>Dhanalakshmi</surname><given-names>S.</given-names></name><name><surname>Mohan</surname><given-names>S.</given-names></name><name><surname>Agarwal</surname><given-names>R.</given-names></name></person-group> (<year>2006</year>). <article-title>Differential effect of silibinin on E2F transcription factors and associated biological events in chronically UVB-exposed skin versus tumors in SKH-1 hairless mice</article-title>. <source>Mol. Cancer Ther.</source> <volume>5</volume>, <fpage>2121</fpage>–<lpage>2129</lpage><pub-id pub-id-type="doi">10.1158/1535-7163.MCT-06-0052</pub-id><pub-id pub-id-type="pmid">16928834</pub-id></mixed-citation></ref><ref id="B45"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gupta</surname><given-names>U.</given-names></name><name><surname>Jahan</surname><given-names>S.</given-names></name><name><surname>Chaudhary</surname><given-names>R.</given-names></name><name><surname>Goyal</surname><given-names>P. K.</given-names></name></person-group> (<year>2008</year>). <article-title>Amelioration of radiation-induced hematological and biochemical alterations by <italic>Alstonia scholaris</italic> (a medicinal plant) extract</article-title>. <source>Integr. Cancer Ther.</source> <volume>7</volume>, <fpage>155</fpage>–<lpage>161</lpage><pub-id pub-id-type="doi">10.1177/1534735408322850</pub-id><pub-id pub-id-type="pmid">18815147</pub-id></mixed-citation></ref><ref id="B46"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Guruvayoorappan</surname><given-names>C.</given-names></name><name><surname>Kuttan</surname><given-names>G.</given-names></name></person-group> (<year>2008</year>). <article-title>Protective effect of <italic>Biophytum sensitivum</italic> (L.) DC on radiation-induced damage in mice</article-title>. <source>Immunopharmacol. Immunotoxicol.</source> <volume>30</volume>, <fpage>815</fpage>–<lpage>835</lpage><pub-id pub-id-type="doi">10.1080/08923970802278276</pub-id><pub-id pub-id-type="pmid">18951225</pub-id></mixed-citation></ref><ref id="B47"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gutheil</surname><given-names>W. G.</given-names></name><name><surname>Reed</surname><given-names>G.</given-names></name><name><surname>Ray</surname><given-names>A.</given-names></name><name><surname>Dhar</surname><given-names>A.</given-names></name></person-group> (<year>2011</year>). <article-title>Crocetin: an agent derived from saffron for prevention and therapy for cancer</article-title>. <source>Curr. Pharm. Biotechnol</source>. [Epub ahead of print].<pub-id pub-id-type="pmid">21466430</pub-id></mixed-citation></ref><ref id="B48"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Halliwell</surname><given-names>B.</given-names></name><name><surname>Gutteridge</surname><given-names>J. M. C.</given-names></name></person-group> (<year>1989</year>). <source>Free Radicals in Biology and Medicine</source>, <edition>2nd Edn.</edition> <publisher-loc>Oxford</publisher-loc>: <publisher-name>Clarendon Press</publisher-name></mixed-citation></ref><ref id="B49"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Han</surname><given-names>G.</given-names></name><name><surname>Zhou</surname><given-names>Y. F.</given-names></name><name><surname>Zhang</surname><given-names>M. S.</given-names></name><name><surname>Cao</surname><given-names>Z.</given-names></name><name><surname>Xie</surname><given-names>C. H.</given-names></name><name><surname>Zhou</surname><given-names>F. X.</given-names></name><name><surname>Peng</surname><given-names>M.</given-names></name><name><surname>Zhang</surname><given-names>W. J.</given-names></name></person-group> (<year>2006</year>). <article-title><italic>Angelica sinensis</italic> down-regulates hydroxyproline and Tgfb1 and provides protection in mice with radiation-induced pulmonary fibrosis</article-title>. <source>Radiat. Res.</source> <volume>165</volume>, <fpage>546</fpage>–<lpage>552</lpage><pub-id pub-id-type="doi">10.1667/RR3516.1</pub-id><pub-id pub-id-type="pmid">16669709</pub-id></mixed-citation></ref><ref id="B50"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hara</surname><given-names>T.</given-names></name><name><surname>Omura-Minamisawa</surname><given-names>M.</given-names></name><name><surname>Kang</surname><given-names>Y.</given-names></name><name><surname>Cheng</surname><given-names>C.</given-names></name><name><surname>Inoue</surname><given-names>T.</given-names></name></person-group> (<year>2008</year>). <article-title>Flavopiridol potentiates the cytotoxic effects of radiation in radioresistant tumor cells in which p53 is mutated or Bcl-2 is overexpressed</article-title>. <source>Int. J. Radiat. Oncol. Biol. Phys.</source> <volume>71</volume>, <fpage>1485</fpage>–<lpage>1495</lpage><pub-id pub-id-type="doi">10.1016/j.ijrobp.2007.10.027</pub-id><pub-id pub-id-type="pmid">18640498</pub-id></mixed-citation></ref><ref id="B51"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Harikumar</surname><given-names>K. B.</given-names></name><name><surname>Kuttan</surname><given-names>R.</given-names></name></person-group> (<year>2007</year>). <article-title>An extract of <italic>Phyllanthus amarus</italic> protects mouse chromosomes and intestine from radiation induced damages</article-title>. <source>J. Radiat. Res.</source> <volume>48</volume>, <fpage>469</fpage>–<lpage>476</lpage><pub-id pub-id-type="doi">10.1269/jrr.07039</pub-id><pub-id pub-id-type="pmid">17917369</pub-id></mixed-citation></ref><ref id="B52"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hasselbalch</surname><given-names>B.</given-names></name><name><surname>Lassen</surname><given-names>U.</given-names></name><name><surname>Hansen</surname><given-names>S.</given-names></name><name><surname>Holmberg</surname><given-names>M.</given-names></name><name><surname>Sørensen</surname><given-names>M.</given-names></name><name><surname>Kosteljanetz</surname><given-names>M.</given-names></name><name><surname>Broholm</surname><given-names>H.</given-names></name><name><surname>Stockhausen</surname><given-names>M. T.</given-names></name><name><surname>Poulsen</surname><given-names>H. S.</given-names></name></person-group> (<year>2010</year>). <article-title>Cetuximab, bevacizumab, and irinotecan for patients with primary glioblastoma and progression after radiation therapy and temozolomide: a phase II trial</article-title>. <source>Neuro-oncology</source> <volume>12</volume>, <fpage>508</fpage>–<lpage>516</lpage><pub-id pub-id-type="pmid">20406901</pub-id></mixed-citation></ref><ref id="B53"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hazra</surname><given-names>B.</given-names></name><name><surname>Das</surname><given-names>S. M.</given-names></name><name><surname>Kumar</surname><given-names>B.</given-names></name><name><surname>Basu</surname><given-names>S.</given-names></name><name><surname>Das</surname><given-names>K.</given-names></name><name><surname>Pandey</surname><given-names>B. N.</given-names></name><name><surname>Mishra</surname><given-names>K. P.</given-names></name></person-group> (<year>2007</year>). <article-title>Cytotoxicity of diospyrin and its derivatives in relation to the generation of reactive oxygen species in tumor cells in vitro and in vivo</article-title>. <source>Chemotherapy</source> <volume>53</volume>, <fpage>173</fpage>–<lpage>176</lpage><pub-id pub-id-type="pmid">17347562</pub-id></mixed-citation></ref><ref id="B54"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hiro</surname><given-names>J.</given-names></name><name><surname>Inoue</surname><given-names>Y.</given-names></name><name><surname>Toiyama</surname><given-names>Y.</given-names></name><name><surname>Yoshiyama</surname><given-names>S.</given-names></name><name><surname>Tanaka</surname><given-names>K.</given-names></name><name><surname>Mohri</surname><given-names>Y.</given-names></name><name><surname>Miki</surname><given-names>C.</given-names></name><name><surname>Kusunoki</surname><given-names>M.</given-names></name></person-group> (<year>2010</year>). <article-title>Possibility of paclitaxel as an alternative radiosensitizer to 5-fluorouracil for colon cancer</article-title>. <source>Oncol. Rep.</source> <volume>24</volume>, <fpage>1029</fpage>–<lpage>1034</lpage><pub-id pub-id-type="pmid">20811685</pub-id></mixed-citation></ref><ref id="B55"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hu</surname><given-names>J.</given-names></name><name><surname>Chen</surname><given-names>L. J.</given-names></name><name><surname>Liu</surname><given-names>L.</given-names></name><name><surname>Chen</surname><given-names>X.</given-names></name><name><surname>Chen</surname><given-names>P. L.</given-names></name><name><surname>Yang</surname><given-names>G.</given-names></name><name><surname>Hou</surname><given-names>W. L.</given-names></name><name><surname>Tang</surname><given-names>M. H.</given-names></name><name><surname>Zhang</surname><given-names>F.</given-names></name><name><surname>Wang</surname><given-names>X. H.</given-names></name><name><surname>Zhao</surname><given-names>X.</given-names></name><name><surname>Wei</surname><given-names>Y. Q.</given-names></name></person-group> (<year>2008</year>). <article-title>Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity</article-title>. <source>Exp. Mol. Med.</source> <volume>40</volume>, <fpage>617</fpage>–<lpage>628</lpage><pub-id pub-id-type="doi">10.3858/emm.2008.40.6.617</pub-id><pub-id pub-id-type="pmid">19116447</pub-id></mixed-citation></ref><ref id="B56"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huang</surname><given-names>C.</given-names></name><name><surname>Zhang</surname><given-names>D.</given-names></name><name><surname>Li</surname><given-names>J.</given-names></name><name><surname>Tong</surname><given-names>Q.</given-names></name><name><surname>Stoner</surname><given-names>G. D.</given-names></name></person-group> (<year>2007</year>). <article-title>Differential inhibition of UV-induced activation of NF kappa B and AP-1 by extracts from black raspberries, strawberries, and blueberries</article-title>. <source>Nutr. Cancer</source> <volume>58</volume>, <fpage>205</fpage>–<lpage>212</lpage><pub-id pub-id-type="doi">10.1080/01635580701328453</pub-id><pub-id pub-id-type="pmid">17640167</pub-id></mixed-citation></ref><ref id="B57"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huang</surname><given-names>J. C.</given-names></name><name><surname>Zhao</surname><given-names>P. C.</given-names></name><name><surname>Zhang</surname><given-names>H. Z.</given-names></name><name><surname>Wang</surname><given-names>H.</given-names></name></person-group> (<year>2011</year>). <article-title>A proteomical study on the radiosensitized target molecules of fuzheng zengxiao formula in pulmonary adenocarcinoma nude mice model</article-title>. <source>J. Tradit. Chin. Med.</source> <volume>31</volume>, <fpage>3</fpage>–<lpage>6</lpage><pub-id pub-id-type="doi">10.1016/S0254-6272(11)60001-0</pub-id><pub-id pub-id-type="pmid">21563497</pub-id></mixed-citation></ref><ref id="B58"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Illum</surname><given-names>H.</given-names></name></person-group> (<year>2011</year>). <article-title>Irinotecan and radiosensitization in rectal cancer</article-title>. <source>Anticancer Drugs</source> <volume>22</volume>, <fpage>324</fpage>–<lpage>329</lpage><pub-id pub-id-type="doi">10.1097/CAD.0b013e3283425c14</pub-id><pub-id pub-id-type="pmid">21160419</pub-id></mixed-citation></ref><ref id="B59"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jagetia</surname><given-names>G. C.</given-names></name></person-group> (<year>2007</year>). <article-title>Radioprotective potential of plants and herbs against the effects of ionizing radiation</article-title>. <source>J. Clin. Biochem. Nutr.</source> <volume>40</volume>, <fpage>74</fpage>–<lpage>81</lpage><pub-id pub-id-type="doi">10.3164/jcbn.40.74</pub-id><pub-id pub-id-type="pmid">18188408</pub-id></mixed-citation></ref><ref id="B60"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jagetia</surname><given-names>G. C.</given-names></name><name><surname>Rajanikant</surname><given-names>G. K.</given-names></name></person-group> (<year>2011</year>). <article-title>Acceleration of wound repair by curcumin in the excision wound of mice exposed to different doses of fractionated γ radiation</article-title>. <source>Int. Wound J.</source> [Epub ahead of print].<pub-id pub-id-type="doi">10.1111/j.1742-481X.2011.00848.x</pub-id></mixed-citation></ref><ref id="B61"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jagetia</surname><given-names>G. C.</given-names></name><name><surname>Shetty</surname><given-names>P. C.</given-names></name><name><surname>Vidyasagar</surname><given-names>M. S.</given-names></name></person-group> (<year>2011</year>). <article-title>Inhibition of radiation-induced DNA damage by Jamun, <italic>Syzygium cumini</italic>, in the cultured splenocytes of mice exposed to different doses of gamma-radiation</article-title>. <source>Integr. Cancer Ther.</source> [Epub ahead of print].<pub-id pub-id-type="pmid">21733986</pub-id></mixed-citation></ref><ref id="B62"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jagetia</surname><given-names>G. C.</given-names></name><name><surname>Venkatesha</surname><given-names>V. A.</given-names></name></person-group> (<year>2006</year>). <article-title>Treatment of mice with stem bark extract of <italic>Aphanamixis polystachya</italic> reduces radiation-induced chromosome damage</article-title>. <source>Int. J. Radiat. Biol.</source> <volume>82</volume>, <fpage>197</fpage>–<lpage>209</lpage><pub-id pub-id-type="doi">10.1080/09553000600621413</pub-id><pub-id pub-id-type="pmid">16638717</pub-id></mixed-citation></ref><ref id="B63"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jahan</surname><given-names>S.</given-names></name><name><surname>Goyal</surname><given-names>P. K.</given-names></name></person-group> (<year>2010</year>). <article-title>Protective effect of <italic>Alstonia scholaris</italic> against radiation-induced clastogenic and biochemical alterations in mice</article-title>. <source>J. Environ. Pathol. Toxicol. Oncol.</source> <volume>29</volume>, <fpage>101</fpage>–<lpage>111</lpage><pub-id pub-id-type="pmid">20932245</pub-id></mixed-citation></ref><ref id="B64"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jeong</surname><given-names>H. C.</given-names></name><name><surname>Lee</surname><given-names>S. Y.</given-names></name><name><surname>Lee</surname><given-names>S. Y.</given-names></name><name><surname>Kim</surname><given-names>J. H.</given-names></name><name><surname>Shin</surname><given-names>C.</given-names></name><name><surname>Shim</surname><given-names>J. J.</given-names></name><name><surname>In</surname><given-names>K. H.</given-names></name><name><surname>Kang</surname><given-names>K. H.</given-names></name><name><surname>Yoo</surname><given-names>S. H.</given-names></name></person-group> (<year>2006</year>). <article-title>Phase II study of irinotecan plus cisplatin with concurrent radiotherapy for the patients with limited-disease small-cell lung cancer</article-title>. <source>Lung Cancer</source> <volume>53</volume>, <fpage>361</fpage>–<lpage>366</lpage><pub-id pub-id-type="doi">10.1016/j.lungcan.2006.06.002</pub-id><pub-id pub-id-type="pmid">16846662</pub-id></mixed-citation></ref><ref id="B65"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jeong</surname><given-names>S. Y.</given-names></name><name><surname>Park</surname><given-names>S. J.</given-names></name><name><surname>Yoon</surname><given-names>S. M.</given-names></name><name><surname>Jung</surname><given-names>J.</given-names></name><name><surname>Woo</surname><given-names>H. N.</given-names></name><name><surname>Yi</surname><given-names>S. L.</given-names></name><name><surname>Song</surname><given-names>S. Y.</given-names></name><name><surname>Park</surname><given-names>H. J.</given-names></name><name><surname>Kim</surname><given-names>C.</given-names></name><name><surname>Lee</surname><given-names>J. S.</given-names></name><name><surname>Lee</surname><given-names>J. S.</given-names></name><name><surname>Choi</surname><given-names>E. K.</given-names></name></person-group> (<year>2009</year>). <article-title>Systemic delivery and preclinical evaluation of Au nanoparticle containing beta-lapachone for radiosensitization</article-title>. <source>J. Control Release.</source> <volume>139</volume>, <fpage>239</fpage>–<lpage>245</lpage><pub-id pub-id-type="doi">10.1016/j.jconrel.2009.07.007</pub-id><pub-id pub-id-type="pmid">19619590</pub-id></mixed-citation></ref><ref id="B66"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jin</surname><given-names>S. L.</given-names></name><name><surname>Zhou</surname><given-names>B. R.</given-names></name><name><surname>Luo</surname><given-names>D.</given-names></name></person-group> (<year>2009</year>). <article-title>Protective effect of epigallocatechin gallate on the immune function of dendritic cells after ultraviolet B irradiation</article-title>. <source>J. Cosmet. Dermatol.</source> <volume>8</volume>, <fpage>174</fpage>–<lpage>180</lpage><pub-id pub-id-type="doi">10.1111/j.1473-2165.2009.00443.x</pub-id><pub-id pub-id-type="pmid">19735514</pub-id></mixed-citation></ref><ref id="B67"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jindal</surname><given-names>A.</given-names></name><name><surname>Agrawal</surname><given-names>A.</given-names></name><name><surname>Goyal</surname><given-names>P. K.</given-names></name></person-group> (<year>2010</year>). <article-title>Influence of Rosemarinus officinalis extract on radiation-induced intestinal injury in mice</article-title>. <source>J. Environ. Pathol. Toxicol. Oncol.</source> <volume>29</volume>, <fpage>169</fpage>–<lpage>179</lpage><pub-id pub-id-type="pmid">21303324</pub-id></mixed-citation></ref><ref id="B68"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jindal</surname><given-names>A.</given-names></name><name><surname>Soyal</surname><given-names>D.</given-names></name><name><surname>Sharma</surname><given-names>A.</given-names></name><name><surname>Goyal</surname><given-names>P. K.</given-names></name></person-group> (<year>2009</year>). <article-title>Protective effect of an extract of <italic>Emblica officinalis</italic> against radiation-induced damage in mice</article-title>. <source>Integr. Cancer Ther.</source> <volume>8</volume>, <fpage>98</fpage>–<lpage>105</lpage><pub-id pub-id-type="doi">10.1177/1534735409331455</pub-id><pub-id pub-id-type="pmid">19223372</pub-id></mixed-citation></ref><ref id="B69"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Johnson</surname><given-names>G. E.</given-names></name><name><surname>Ivanov</surname><given-names>V. N.</given-names></name><name><surname>Hei</surname><given-names>T. K.</given-names></name></person-group> (<year>2008</year>). <article-title>Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival</article-title>. <source>Apoptosis</source> <volume>13</volume>, <fpage>790</fpage>–<lpage>802</lpage><pub-id pub-id-type="doi">10.1007/s10495-008-0212-y</pub-id><pub-id pub-id-type="pmid">18454317</pub-id></mixed-citation></ref><ref id="B70"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kalthur</surname><given-names>G.</given-names></name><name><surname>Pathirissery</surname><given-names>U. D.</given-names></name></person-group> (<year>2010</year>). <article-title>Enhancement of the response of B16F1 melanoma to fractionated radiotherapy and prolongation of survival by withaferin A and/or hyperthermia</article-title>. <source>Integr. Cancer Ther.</source> <volume>9</volume>, <fpage>370</fpage>–<lpage>377</lpage><pub-id pub-id-type="doi">10.1177/1534735410378664</pub-id><pub-id pub-id-type="pmid">20713375</pub-id></mixed-citation></ref><ref id="B71"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kamata</surname><given-names>H.</given-names></name><name><surname>Shibukawa</surname><given-names>Y.</given-names></name><name><surname>Oka</surname><given-names>S. I.</given-names></name><name><surname>Hirata</surname><given-names>H.</given-names></name></person-group> (<year>2000</year>). <article-title>Epidermal growth factor receptor is modulated by redox through multiple mechanisms. Effects of reductants and H2O2</article-title>. <source>Eur. J. Biochem.</source> <volume>267</volume>, <fpage>1933</fpage>–<lpage>1944</lpage><pub-id pub-id-type="doi">10.1046/j.1432-1327.2000.01194.x</pub-id><pub-id pub-id-type="pmid">10727932</pub-id></mixed-citation></ref><ref id="B72"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kao</surname><given-names>C. L.</given-names></name><name><surname>Huang</surname><given-names>P. I.</given-names></name><name><surname>Tsai</surname><given-names>P. H.</given-names></name><name><surname>Tsai</surname><given-names>M. L.</given-names></name><name><surname>Lo</surname><given-names>J. F.</given-names></name><name><surname>Lee</surname><given-names>Y. Y.</given-names></name><name><surname>Chen</surname><given-names>Y. J.</given-names></name><name><surname>Chen</surname><given-names>Y. W.</given-names></name><name><surname>Chiou</surname><given-names>S. H.</given-names></name></person-group> (<year>2009</year>). <article-title>Resveratrol-induced apoptosis and increased radiosensitivity in CD133-positive cells derived from atypical teratoid/rhabdoid tumor</article-title>. <source>Int. J. Radiat. Oncol. Biol. Phys.</source> <volume>74</volume>, <fpage>219</fpage>–<lpage>228</lpage><pub-id pub-id-type="doi">10.1016/j.ijrobp.2008.12.035</pub-id><pub-id pub-id-type="pmid">19362240</pub-id></mixed-citation></ref><ref id="B73"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Katiyar</surname><given-names>S. K.</given-names></name><name><surname>Afaq</surname><given-names>F.</given-names></name><name><surname>Azizuddin</surname><given-names>K.</given-names></name><name><surname>Mukhtar</surname><given-names>H.</given-names></name></person-group> (<year>2001</year>). <article-title>Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mitogen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol (-)-epigallocatechin-3-gallate</article-title>. <source>Toxicol. Appl. Pharmacol.</source> <volume>176</volume>, <fpage>110</fpage>–<lpage>117</lpage><pub-id pub-id-type="doi">10.1006/taap.2001.9276</pub-id><pub-id pub-id-type="pmid">11601887</pub-id></mixed-citation></ref><ref id="B74"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Katiyar</surname><given-names>S. K.</given-names></name><name><surname>Mantena</surname><given-names>S. K.</given-names></name><name><surname>Meeran</surname><given-names>S. M.</given-names></name></person-group> (<year>2011</year>). <article-title>Silymarin protects epidermal keratinocytes from ultraviolet radiation-induced apoptosis and DNA damage by nucleotide excision repair mechanism</article-title>. <source>PLoS ONE</source> <volume>6</volume>, <fpage>e21410</fpage><pub-id pub-id-type="doi">10.1371/journal.pone.0021410</pub-id><pub-id pub-id-type="pmid">21731736</pub-id></mixed-citation></ref><ref id="B75"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Katiyar</surname><given-names>S. K.</given-names></name><name><surname>Meleth</surname><given-names>S.</given-names></name><name><surname>Sharma</surname><given-names>S. D.</given-names></name></person-group> (<year>2008</year>). <article-title>Silymarin, a flavonoid from milk thistle (<italic>Silybum marianum</italic> L.), inhibits UV-induced oxidative stress through targeting infiltrating CD11b<sup>+</sup> cells in mouse skin</article-title>. <source>Photochem. Photobiol.</source> <volume>84</volume>, <fpage>266</fpage>–<lpage>271</lpage><pub-id pub-id-type="doi">10.1111/j.1751-1097.2007.00241.x</pub-id><pub-id pub-id-type="pmid">18221354</pub-id></mixed-citation></ref><ref id="B76"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kienle</surname><given-names>G. S.</given-names></name><name><surname>Kiene</surname><given-names>H.</given-names></name></person-group> (<year>2010</year>). <article-title>Review article: influence of <italic>Viscum album</italic> L (European mistletoe) extracts on quality of life in cancer patients: a systematic review of controlled clinical studies</article-title>. <source>Integr. Cancer Ther.</source> <volume>9</volume>, <fpage>142</fpage>–<lpage>157</lpage><pub-id pub-id-type="doi">10.1177/1534735410369673</pub-id><pub-id pub-id-type="pmid">20483874</pub-id></mixed-citation></ref><ref id="B77"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kimura</surname><given-names>Y.</given-names></name><name><surname>Sumiyoshi</surname><given-names>M.</given-names></name></person-group> (<year>2009</year>). <article-title>Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice</article-title>. <source>J. Nutr.</source> <volume>139</volume>, <fpage>2079</fpage>–<lpage>2086</lpage><pub-id pub-id-type="doi">10.3945/jn.109.104992</pub-id><pub-id pub-id-type="pmid">19776181</pub-id></mixed-citation></ref><ref id="B78"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kinsella</surname><given-names>T. J.</given-names></name></person-group> (<year>2011</year>). <article-title>Radiation oncology: today and tomorrow</article-title>. <source>Front. Oncol.</source> <volume>1</volume>:<fpage>1</fpage>–<lpage>2</lpage><pub-id pub-id-type="doi">10.3389/fonc.2011.00007</pub-id></mixed-citation></ref><ref id="B79"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Klautke</surname><given-names>G.</given-names></name><name><surname>Küchenmeister</surname><given-names>U.</given-names></name><name><surname>Foitzik</surname><given-names>T.</given-names></name><name><surname>Ludwig</surname><given-names>K.</given-names></name><name><surname>Prall</surname><given-names>F.</given-names></name><name><surname>Klar</surname><given-names>E.</given-names></name><name><surname>Fietkau</surname><given-names>R.</given-names></name></person-group> (<year>2006</year>). <article-title>Concurrent chemoradiation with capecitabine and weekly irinotecan as preoperative treatment for rectal cancer: results from a phase I/II study</article-title>. <source>Br. J. Cancer</source> <volume>94</volume>, <fpage>976</fpage>–<lpage>981</lpage><pub-id pub-id-type="doi">10.1038/sj.bjc.6603053</pub-id><pub-id pub-id-type="pmid">16552435</pub-id></mixed-citation></ref><ref id="B80"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kondo</surname><given-names>S.</given-names></name><name><surname>Toyokuni</surname><given-names>S.</given-names></name><name><surname>Iwasa</surname><given-names>Y.</given-names></name><name><surname>Tanaka</surname><given-names>T.</given-names></name><name><surname>Onodera</surname><given-names>H.</given-names></name><name><surname>Hiai</surname><given-names>H.</given-names></name></person-group> (<year>1999</year>). <article-title>Persistent oxidative stress in human colorectal carcinoma, but not in adenoma</article-title>. <source>Free Radic. Biol. Med.</source> <volume>27</volume>, <fpage>401</fpage>–<lpage>410</lpage><pub-id pub-id-type="doi">10.1016/S0891-5849(99)00133-1</pub-id><pub-id pub-id-type="pmid">10468215</pub-id></mixed-citation></ref><ref id="B81"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kumar</surname><given-names>B.</given-names></name><name><surname>Joshi</surname><given-names>J.</given-names></name><name><surname>Kumar</surname><given-names>A.</given-names></name><name><surname>Pandey</surname><given-names>B. N.</given-names></name><name><surname>Hazra</surname><given-names>B.</given-names></name><name><surname>Mishra</surname><given-names>K. P.</given-names></name></person-group> (<year>2007</year>). <article-title>Radiosensitization by diospyrin diethylether in MCF-7 breast carcinoma cell line</article-title>. <source>Mol. Cell. Biochem.</source> <volume>304</volume>, <fpage>287</fpage>–<lpage>296</lpage><pub-id pub-id-type="doi">10.1007/s11010-007-9511-9</pub-id><pub-id pub-id-type="pmid">17534696</pub-id></mixed-citation></ref><ref id="B82"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kumar</surname><given-names>B.</given-names></name><name><surname>Kumar</surname><given-names>A.</given-names></name><name><surname>Pandey</surname><given-names>B. N.</given-names></name><name><surname>Hazra</surname><given-names>B.</given-names></name><name><surname>Mishra</surname><given-names>K. P.</given-names></name></person-group> (<year>2008</year>). <article-title>Increased cytotoxicity by the combination of radiation and diospyrin diethylether in fibrosarcoma in culture and in tumor</article-title>. <source>Int. J. Radiat. Biol.</source> <volume>84</volume>, <fpage>429</fpage>–<lpage>440</lpage><pub-id pub-id-type="doi">10.1080/09553000801983133</pub-id><pub-id pub-id-type="pmid">18464072</pub-id></mixed-citation></ref><ref id="B83"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kundu</surname><given-names>J. K.</given-names></name><name><surname>Chang</surname><given-names>E. J.</given-names></name><name><surname>Fujii</surname><given-names>H.</given-names></name><name><surname>Sun</surname><given-names>B.</given-names></name><name><surname>Surh</surname><given-names>Y. J.</given-names></name></person-group> (<year>2008</year>). <article-title>Oligonol inhibits UVB-induced COX-2 expression in HR-1 hairless mouse skin – AP-1 and C/EBP as potential upstream targets</article-title>. <source>Photochem. Photobiol.</source> <volume>84</volume>, <fpage>399</fpage>–<lpage>406</lpage><pub-id pub-id-type="doi">10.1111/j.1751-1097.2007.00277.x</pub-id><pub-id pub-id-type="pmid">18221453</pub-id></mixed-citation></ref><ref id="B84"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Langer</surname><given-names>C. J.</given-names></name><name><surname>Somer</surname><given-names>R.</given-names></name><name><surname>Litwin</surname><given-names>S.</given-names></name><name><surname>Feigenberg</surname><given-names>S.</given-names></name><name><surname>Movsas</surname><given-names>B.</given-names></name><name><surname>Maiale</surname><given-names>C.</given-names></name><name><surname>Sherman</surname><given-names>E.</given-names></name><name><surname>Millenson</surname><given-names>M.</given-names></name><name><surname>Nicoloau</surname><given-names>N.</given-names></name><name><surname>Huang</surname><given-names>C.</given-names></name><name><surname>Treat</surname><given-names>J.</given-names></name></person-group> (<year>2007</year>). <article-title>Phase I study of radical thoracic radiation, weekly irinotecan, and cisplatin in locally advanced non-small cell lung carcinoma</article-title>. <source>J. Thorac. Oncol.</source> <volume>2</volume>, <fpage>203</fpage>–<lpage>209</lpage><pub-id pub-id-type="doi">10.1097/01.JTO.0000283410.30744.4f</pub-id><pub-id pub-id-type="pmid">17410043</pub-id></mixed-citation></ref><ref id="B85"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>D. E.</given-names></name><name><surname>Lee</surname><given-names>K. W.</given-names></name><name><surname>Byun</surname><given-names>S.</given-names></name><name><surname>Jung</surname><given-names>S. K.</given-names></name><name><surname>Song</surname><given-names>N.</given-names></name><name><surname>Lim</surname><given-names>S. H.</given-names></name><name><surname>Heo</surname><given-names>Y. S.</given-names></name><name><surname>Kim</surname><given-names>J. E.</given-names></name><name><surname>Kang</surname><given-names>N. J.</given-names></name><name><surname>Kim</surname><given-names>B. Y.</given-names></name><name><surname>Bowden</surname><given-names>G. T.</given-names></name><name><surname>Bode</surname><given-names>A. M.</given-names></name><name><surname>Lee</surname><given-names>H. J.</given-names></name><name><surname>Dong</surname><given-names>Z.</given-names></name></person-group> (<year>2011</year>). <article-title>7,3′,4′-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4</article-title>. <source>J. Biol. Chem.</source> <volume>286</volume>, <fpage>14246</fpage>–<lpage>14256</lpage><pub-id pub-id-type="doi">10.1074/jbc.M110.209379</pub-id><pub-id pub-id-type="pmid">21378167</pub-id></mixed-citation></ref><ref id="B86"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>H. J.</given-names></name><name><surname>Kim</surname><given-names>J. S.</given-names></name><name><surname>Moon</surname><given-names>C.</given-names></name><name><surname>Kim</surname><given-names>J. C.</given-names></name><name><surname>Lee</surname><given-names>Y. S.</given-names></name><name><surname>Jang</surname><given-names>J. S.</given-names></name><name><surname>Jo</surname><given-names>S. K.</given-names></name><name><surname>Kim</surname><given-names>S. H.</given-names></name></person-group> (<year>2008a</year>). <article-title>Modification of gamma-radiation response in mice by green tea polyphenols</article-title>. <source>Phytother. Res.</source> <volume>22</volume>, <fpage>1380</fpage>–<lpage>1383</lpage><pub-id pub-id-type="doi">10.1002/ptr.2296</pub-id><pub-id pub-id-type="pmid">18570224</pub-id></mixed-citation></ref><ref id="B87"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>T. K.</given-names></name><name><surname>Wang</surname><given-names>W.</given-names></name><name><surname>O’Brien</surname><given-names>K. F.</given-names></name><name><surname>Johnke</surname><given-names>R. M.</given-names></name><name><surname>Wang</surname><given-names>T.</given-names></name><name><surname>Allison</surname><given-names>R. R.</given-names></name><name><surname>Diaz</surname><given-names>A. L.</given-names></name></person-group> (<year>2008b</year>). <article-title>Effect of North American ginseng on 137Cs-induced micronuclei in human lymphocytes: a comparison with WR-1065</article-title>. <source>Phytother. Res.</source> <volume>22</volume>, <fpage>1614</fpage>–<lpage>1622</lpage><pub-id pub-id-type="doi">10.1002/ptr.2296</pub-id><pub-id pub-id-type="pmid">18803249</pub-id></mixed-citation></ref><ref id="B88"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>H. J.</given-names></name><name><surname>Kim</surname><given-names>J. S.</given-names></name><name><surname>Song</surname><given-names>M. S.</given-names></name><name><surname>Seo</surname><given-names>H. S.</given-names></name><name><surname>Moon</surname><given-names>C.</given-names></name><name><surname>Kim</surname><given-names>J. C.</given-names></name><name><surname>Jo</surname><given-names>S. K.</given-names></name><name><surname>Jang</surname><given-names>J. S.</given-names></name><name><surname>Kim</surname><given-names>S. H.</given-names></name></person-group> (<year>2009</year>). <article-title>Photoprotective effect of red ginseng against ultraviolet radiation-induced chronic skin damage in the hairless mouse</article-title>. <source>Phytother. Res.</source> <volume>23</volume>, <fpage>399</fpage>–<lpage>403</lpage><pub-id pub-id-type="doi">10.1002/ptr.2836</pub-id><pub-id pub-id-type="pmid">18979525</pub-id></mixed-citation></ref><ref id="B89"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>S. M.</given-names></name><name><surname>Li</surname><given-names>M. L.</given-names></name><name><surname>Tse</surname><given-names>Y. C.</given-names></name><name><surname>Leung</surname><given-names>S. C.</given-names></name><name><surname>Lee</surname><given-names>M. M.</given-names></name><name><surname>Tsui</surname><given-names>S. K.</given-names></name></person-group> (<year>2002</year>). <article-title>Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway</article-title>. <source>Life Sci.</source> <volume>71</volume>, <fpage>2267</fpage>–<lpage>2277</lpage><pub-id pub-id-type="doi">10.1016/S0024-3205(02)01962-8</pub-id><pub-id pub-id-type="pmid">12215374</pub-id></mixed-citation></ref><ref id="B90"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>T. K.</given-names></name><name><surname>O’Brien</surname><given-names>K. F.</given-names></name><name><surname>Wang</surname><given-names>W.</given-names></name><name><surname>Johnke</surname><given-names>R. M.</given-names></name><name><surname>Sheng</surname><given-names>C.</given-names></name><name><surname>Benhabib</surname><given-names>S. M.</given-names></name><name><surname>Wang</surname><given-names>T.</given-names></name><name><surname>Allison</surname><given-names>R. R.</given-names></name></person-group> (<year>2010</year>). <article-title>Radioprotective effect of American ginseng on human lymphocytes at 90 minutes postirradiation: a study of 40 cases</article-title>. <source>J. Altern. Complement. Med.</source> <volume>16</volume>, <fpage>561</fpage>–<lpage>567</lpage><pub-id pub-id-type="doi">10.1089/acm.2009.0590</pub-id><pub-id pub-id-type="pmid">20491513</pub-id></mixed-citation></ref><ref id="B91"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>L. H.</given-names></name><name><surname>Wu</surname><given-names>L. J.</given-names></name><name><surname>Tashiro</surname><given-names>S. I.</given-names></name><name><surname>Onodera</surname><given-names>S.</given-names></name><name><surname>Uchiumi</surname><given-names>F.</given-names></name><name><surname>Ikejima</surname><given-names>T.</given-names></name></person-group> (<year>2007</year>). <article-title>Activation of the SIRT1 pathway and modulation of the cell cycle were involved in silymarin’s protection against UV-induced A375-S2 cell apoptosis</article-title>. <source>J. Asian Nat. Prod. Res.</source> <volume>9</volume>, <fpage>245</fpage>–<lpage>252</lpage><pub-id pub-id-type="doi">10.1080/10286020500384302</pub-id><pub-id pub-id-type="pmid">17566917</pub-id></mixed-citation></ref><ref id="B92"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>L. J.</given-names></name><name><surname>Lai-Fu</surname><given-names>Z.</given-names></name><name><surname>Li-Ping</surname><given-names>J.</given-names></name><name><surname>Cheng-Yan</surname><given-names>G.</given-names></name><name><surname>Li-Juan</surname><given-names>Z.</given-names></name></person-group> (<year>2011</year>). <article-title>β-Elemene Radiosensitizes Lung Cancer A549 Cells by Enhancing DNA Damage and Inhibiting DNA Repair</article-title>. <source>Phytother. Res.</source> <volume>25</volume>, <fpage>1095</fpage>–<lpage>1097</lpage><pub-id pub-id-type="doi">10.1002/ptr.3478</pub-id></mixed-citation></ref><ref id="B93"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lillo</surname><given-names>O.</given-names></name><name><surname>Bracesco</surname><given-names>N.</given-names></name><name><surname>Nunes</surname><given-names>E.</given-names></name></person-group> (<year>2011</year>). <article-title>Lethal and mutagenic interactions between γ-rays, cisplatin and etoposide at the cellular and molecular levels</article-title>. <source>Int. J. Radiat. Biol.</source> <volume>87</volume>, <fpage>222</fpage>–<lpage>230</lpage><pub-id pub-id-type="doi">10.3109/09553002.2010.518207</pub-id><pub-id pub-id-type="pmid">21133647</pub-id></mixed-citation></ref><ref id="B94"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Liu</surname><given-names>Y.</given-names></name><name><surname>Chan</surname><given-names>F.</given-names></name><name><surname>Sun</surname><given-names>H.</given-names></name><name><surname>Yan</surname><given-names>J.</given-names></name><name><surname>Fan</surname><given-names>D.</given-names></name><name><surname>Zhao</surname><given-names>D.</given-names></name><name><surname>An</surname><given-names>J.</given-names></name><name><surname>Zhou</surname><given-names>D.</given-names></name></person-group> (<year>2011</year>). <article-title>Resveratrol protects human keratinocytes HaCaT cells from UVA-induced oxidative stress damage by downregulating Keap1 expression</article-title>. <source>Eur. J. Pharmacol.</source> <volume>650</volume>, <fpage>130</fpage>–<lpage>137</lpage><pub-id pub-id-type="doi">10.1016/j.ejphar.2010.09.082</pub-id><pub-id pub-id-type="pmid">20951123</pub-id></mixed-citation></ref><ref id="B95"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Loo</surname><given-names>G.</given-names></name></person-group> (<year>2003</year>). <article-title>Redox-sensitive mechanisms of phytochemical-mediated inhibition of cancer cell proliferation</article-title>. <source>J. Nutr. Biochem.</source> <volume>14</volume>, <fpage>64</fpage>–<lpage>73</lpage><pub-id pub-id-type="doi">10.1016/S0955-2863(02)00251-6</pub-id><pub-id pub-id-type="pmid">12667597</pub-id></mixed-citation></ref><ref id="B96"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Madhusoodhanan</surname><given-names>R.</given-names></name><name><surname>Natarajan</surname><given-names>M.</given-names></name><name><surname>Singh</surname><given-names>J. V.</given-names></name><name><surname>Jamgade</surname><given-names>A.</given-names></name><name><surname>Awasthi</surname><given-names>V.</given-names></name><name><surname>Anant</surname><given-names>S.</given-names></name><name><surname>Herman</surname><given-names>T. S.</given-names></name><name><surname>Aravindan</surname><given-names>N.</given-names></name></person-group> (<year>2010</year>). <article-title>Effect of black raspberry extract in inhibiting NFkappa B dependent radioprotection in human breast cancer cells</article-title>. <source>Nutr. Cancer</source> <volume>62</volume>, <fpage>93</fpage>–<lpage>104</lpage><pub-id pub-id-type="doi">10.1080/01635580903191494</pub-id><pub-id pub-id-type="pmid">20043264</pub-id></mixed-citation></ref><ref id="B97"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mahmood</surname><given-names>J.</given-names></name><name><surname>Jelveh</surname><given-names>S.</given-names></name><name><surname>Calveley</surname><given-names>V.</given-names></name><name><surname>Zaidi</surname><given-names>A.</given-names></name><name><surname>Doctrow</surname><given-names>S. R.</given-names></name><name><surname>Hill</surname><given-names>R. P.</given-names></name></person-group> (<year>2011</year>). <article-title>Mitigation of radiation-induced lung injury by genistein and EUK-207</article-title>. <source>Int. J. Radiat. Biol.</source> <volume>87</volume>, <fpage>889</fpage>–<lpage>901</lpage><pub-id pub-id-type="doi">10.3109/09553002.2011.583315</pub-id><pub-id pub-id-type="pmid">21675818</pub-id></mixed-citation></ref><ref id="B98"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Majeed</surname><given-names>M.</given-names></name><name><surname>Bhat</surname><given-names>B.</given-names></name><name><surname>Anand</surname><given-names>S.</given-names></name><name><surname>Sivakumar</surname><given-names>A.</given-names></name><name><surname>Paliwal</surname><given-names>P.</given-names></name><name><surname>Geetha</surname><given-names>K. G.</given-names></name></person-group> (<year>2011</year>). <article-title>Inhibition of UV-induced ROS and collagen damage by Phyllanthus emblica extract in normal human dermal fibroblasts</article-title>. <source>J. Cosmet. Sci.</source> <volume>62</volume>, <fpage>49</fpage>–<lpage>56</lpage><pub-id pub-id-type="pmid">21443845</pub-id></mixed-citation></ref><ref id="B99"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Manna</surname><given-names>S. K.</given-names></name><name><surname>Mukhopadhyay</surname><given-names>A.</given-names></name><name><surname>Aggarwal</surname><given-names>B. B.</given-names></name></person-group> (<year>2000</year>). <article-title>Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation</article-title>. <source>J. Immunol.</source> <volume>164</volume>, <fpage>6509</fpage>–<lpage>6519</lpage><pub-id pub-id-type="pmid">10843709</pub-id></mixed-citation></ref><ref id="B100"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Manu</surname><given-names>K. A.</given-names></name><name><surname>Leyon</surname><given-names>P. V.</given-names></name><name><surname>Kuttan</surname><given-names>G.</given-names></name></person-group> (<year>2007</year>). <article-title>Studies on the protective effects of <italic>Boerhaavia diffusa</italic> L. against gamma radiation induced damage in mice</article-title>. <source>Integr. Cancer. Ther.</source> <volume>6</volume>, <fpage>381</fpage>–<lpage>388</lpage><pub-id pub-id-type="doi">10.1177/1534735407309743</pub-id><pub-id pub-id-type="pmid">18048886</pub-id></mixed-citation></ref><ref id="B101"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>McLaughlin</surname><given-names>N.</given-names></name><name><surname>Annabi</surname><given-names>B.</given-names></name><name><surname>Lachambre</surname><given-names>M. P.</given-names></name><name><surname>Kim</surname><given-names>K. S.</given-names></name><name><surname>Bahary</surname><given-names>J. P.</given-names></name><name><surname>Moumdjian</surname><given-names>R.</given-names></name><name><surname>Béliveau</surname><given-names>R.</given-names></name></person-group> (<year>2006</year>). <article-title>Combined low dose ionizing radiation and green tea-derived epigallocatechin-3-gallate treatment induces human brain endothelial cells death</article-title>. <source>J. Neurooncol.</source> <volume>80</volume>, <fpage>111</fpage>–<lpage>121</lpage><pub-id pub-id-type="doi">10.1007/s11060-006-9171-8</pub-id><pub-id pub-id-type="pmid">16715350</pub-id></mixed-citation></ref><ref id="B102"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Meeran</surname><given-names>S. M.</given-names></name><name><surname>Katiyar</surname><given-names>S.</given-names></name><name><surname>Elmets</surname><given-names>C. A.</given-names></name><name><surname>Katiyar</surname><given-names>S. K.</given-names></name></person-group> (<year>2006</year>). <article-title>Silymarin inhibits UV radiation-induced immunosuppression through augmentation of interleukin-12 in mice</article-title>. <source>Mol. Cancer Ther.</source> <volume>5</volume>, <fpage>1660</fpage>–<lpage>1668</lpage><pub-id pub-id-type="doi">10.1158/1535-7163.MCT-06-0003</pub-id><pub-id pub-id-type="pmid">16891451</pub-id></mixed-citation></ref><ref id="B103"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Meyer</surname><given-names>M.</given-names></name><name><surname>Pahl</surname><given-names>H. L.</given-names></name><name><surname>Baeuerle</surname><given-names>P. A.</given-names></name></person-group> (<year>1994</year>). <article-title>Regulation of the transcription factors NF-kappa B and AP-1 by redox changes</article-title>. <source>Chem. Biol. Interact.</source> <volume>91</volume>, <fpage>91</fpage>–<lpage>100</lpage><pub-id pub-id-type="doi">10.1016/0009-2797(94)90029-9</pub-id><pub-id pub-id-type="pmid">8194138</pub-id></mixed-citation></ref><ref id="B104"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mouria</surname><given-names>M.</given-names></name><name><surname>Gukovskaya</surname><given-names>A. S.</given-names></name><name><surname>Jung</surname><given-names>Y.</given-names></name><name><surname>Buechler</surname><given-names>P.</given-names></name><name><surname>Hines</surname><given-names>O. J.</given-names></name><name><surname>Reber</surname><given-names>H. A.</given-names></name></person-group> (<year>2002</year>). <article-title>Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome c release and apoptosis</article-title>. <source>Int. J. Cancer</source> <volume>98</volume>, <fpage>761</fpage>–<lpage>769</lpage><pub-id pub-id-type="doi">10.1002/ijc.10202</pub-id><pub-id pub-id-type="pmid">11920648</pub-id></mixed-citation></ref><ref id="B105"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Muller</surname><given-names>J. M.</given-names></name><name><surname>Rupec</surname><given-names>R. A.</given-names></name><name><surname>Baeuerle</surname><given-names>P. A.</given-names></name></person-group> (<year>1997</year>). <article-title>Study of gene regulation by NF-kappa B and AP-1 in response to reactive oxygen intermediates</article-title>. <source>Methods</source> <volume>11</volume>, <fpage>301</fpage>–<lpage>312</lpage><pub-id pub-id-type="doi">10.1006/meth.1996.0424</pub-id><pub-id pub-id-type="pmid">9073573</pub-id></mixed-citation></ref><ref id="B106"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Murley</surname><given-names>J. S.</given-names></name><name><surname>Kataoka</surname><given-names>Y.</given-names></name><name><surname>Cao</surname><given-names>D.</given-names></name><name><surname>Li</surname><given-names>J. J.</given-names></name><name><surname>Oberley</surname><given-names>L. W.</given-names></name><name><surname>Grdina</surname><given-names>D. J.</given-names></name></person-group> (<year>2004</year>). <article-title>Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs</article-title>. <source>Radiat. Res.</source> <volume>162</volume>, <fpage>536</fpage>–<lpage>546</lpage><pub-id pub-id-type="doi">10.1667/RR3256</pub-id><pub-id pub-id-type="pmid">15624308</pub-id></mixed-citation></ref><ref id="B107"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nair</surname><given-names>S.</given-names></name><name><surname>Nair</surname><given-names>R. R.</given-names></name><name><surname>Srinivas</surname><given-names>P.</given-names></name><name><surname>Srinivas</surname><given-names>G.</given-names></name><name><surname>Pillai</surname><given-names>M. R.</given-names></name></person-group> (<year>2008</year>). <article-title>Radiosensitizing effects of plumbagin in cervical cancer cells is through modulation of apoptotic pathway</article-title>. <source>Mol. Carcinog.</source> <volume>47</volume>, <fpage>22</fpage>–<lpage>33</lpage><pub-id pub-id-type="doi">10.1002/mc.20359</pub-id><pub-id pub-id-type="pmid">17562542</pub-id></mixed-citation></ref><ref id="B108"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Navarro</surname><given-names>M.</given-names></name><name><surname>Dotor</surname><given-names>E.</given-names></name><name><surname>Rivera</surname><given-names>F.</given-names></name><name><surname>Sánchez-Rovira</surname><given-names>P.</given-names></name><name><surname>Vega-Villegas</surname><given-names>M. E.</given-names></name><name><surname>Cervantes</surname><given-names>A.</given-names></name><name><surname>García</surname><given-names>J. L.</given-names></name><name><surname>Gallén</surname><given-names>M.</given-names></name><name><surname>Aranda</surname><given-names>E.</given-names></name></person-group> (<year>2006</year>). <article-title>A Phase II study of preoperative radiotherapy and concomitant weekly irinotecan in combination with protracted venous infusion 5-fluorouracil, for resectable locally advanced rectal cancer</article-title>. <source>Int. J. Radiat. Oncol. Biol. Phys.</source> <volume>66</volume>, <fpage>201</fpage>–<lpage>205</lpage><pub-id pub-id-type="doi">10.1016/j.ijrobp.2006.04.007</pub-id><pub-id pub-id-type="pmid">16814947</pub-id></mixed-citation></ref><ref id="B109"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Newcomb</surname><given-names>E. W.</given-names></name><name><surname>Lymberis</surname><given-names>S. C.</given-names></name><name><surname>Lukyanov</surname><given-names>Y.</given-names></name><name><surname>Shao</surname><given-names>Y.</given-names></name><name><surname>Schnee</surname><given-names>T.</given-names></name><name><surname>Devitt</surname><given-names>M.</given-names></name><name><surname>Rosenstein</surname><given-names>B. S.</given-names></name><name><surname>Zagzag</surname><given-names>D.</given-names></name><name><surname>Formenti</surname><given-names>S. C.</given-names></name></person-group> (<year>2006</year>). <article-title>Radiation sensitivity of GL261 murine glioma model and enhanced radiation response by flavopiridol</article-title>. <source>Cell Cycle</source> <volume>5</volume>, <fpage>93</fpage>–<lpage>99</lpage><pub-id pub-id-type="doi">10.4161/cc.5.1.2271</pub-id><pub-id pub-id-type="pmid">16319534</pub-id></mixed-citation></ref><ref id="B110"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ng</surname><given-names>A. K.</given-names></name><name><surname>Bernardo</surname><given-names>M. V.</given-names></name><name><surname>Weller</surname><given-names>E.</given-names></name><name><surname>Backstrand</surname><given-names>K.</given-names></name><name><surname>Silver</surname><given-names>B.</given-names></name><name><surname>Marcus</surname><given-names>K. C.</given-names></name><name><surname>Tarbell</surname><given-names>N. J.</given-names></name><name><surname>Stevenson</surname><given-names>M. A.</given-names></name><name><surname>Friedberg</surname><given-names>J. W.</given-names></name><name><surname>Mauch</surname><given-names>P. M.</given-names></name></person-group> (<year>2002</year>). <article-title>Second malignancy after Hodgkin disease treated with radiation therapy with or without chemotherapy: long-term risks and risk factors</article-title>. <source>Blood</source> <volume>100</volume>, <fpage>1989</fpage>–<lpage>1996</lpage><pub-id pub-id-type="doi">10.1182/blood-2002-02-0634</pub-id><pub-id pub-id-type="pmid">12200357</pub-id></mixed-citation></ref><ref id="B111"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Oehler</surname><given-names>C.</given-names></name><name><surname>Dickinson</surname><given-names>D. J.</given-names></name><name><surname>Broggini-Tenzer</surname><given-names>A.</given-names></name><name><surname>Hofstetter</surname><given-names>B.</given-names></name><name><surname>Hollenstein</surname><given-names>A.</given-names></name><name><surname>Riesterer</surname><given-names>O.</given-names></name><name><surname>Vuong</surname><given-names>V.</given-names></name><name><surname>Pruschy</surname><given-names>M.</given-names></name></person-group> (<year>2007</year>). <article-title>Current concepts for the combined treatment modality of ionizing radiation with anticancer agents</article-title>. <source>Curr. Pharm. Des.</source> <volume>13</volume>, <fpage>519</fpage>–<lpage>535</lpage><pub-id pub-id-type="doi">10.2174/138161207780162935</pub-id><pub-id pub-id-type="pmid">17348847</pub-id></mixed-citation></ref><ref id="B112"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Okunieff</surname><given-names>P.</given-names></name><name><surname>Xu</surname><given-names>J.</given-names></name><name><surname>Hu</surname><given-names>D.</given-names></name><name><surname>Liu</surname><given-names>W.</given-names></name><name><surname>Zhang</surname><given-names>L.</given-names></name><name><surname>Morrow</surname><given-names>G.</given-names></name><name><surname>Pentland</surname><given-names>A.</given-names></name><name><surname>Ryan</surname><given-names>J. L.</given-names></name><name><surname>Ding</surname><given-names>I.</given-names></name></person-group> (<year>2006</year>). <article-title>Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines</article-title>. <source>Int. J. Radiat. Oncol. Biol. Phys.</source> <volume>65</volume>, <fpage>890</fpage>–<lpage>898</lpage><pub-id pub-id-type="doi">10.1016/j.ijrobp.2006.03.025</pub-id><pub-id pub-id-type="pmid">16751071</pub-id></mixed-citation></ref><ref id="B113"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Orditura</surname><given-names>M.</given-names></name><name><surname>Galizia</surname><given-names>G.</given-names></name><name><surname>Napolitano</surname><given-names>V.</given-names></name><name><surname>Martinelli</surname><given-names>E.</given-names></name><name><surname>Pacelli</surname><given-names>R.</given-names></name><name><surname>Lieto</surname><given-names>E.</given-names></name><name><surname>Aurilio</surname><given-names>G.</given-names></name><name><surname>Vecchione</surname><given-names>L.</given-names></name><name><surname>Morgillo</surname><given-names>F.</given-names></name><name><surname>Catalano</surname><given-names>G.</given-names></name><name><surname>Ciardiello</surname><given-names>F.</given-names></name><name><surname>Del Genio</surname><given-names>A.</given-names></name><name><surname>Di Martino</surname><given-names>N.</given-names></name><name><surname>De Vita</surname><given-names>F.</given-names></name></person-group> (<year>2010</year>). <article-title>Weekly chemotherapy with cisplatin and paclitaxel and concurrent radiation therapy as preoperative treatment in locally advanced esophageal cancer: a phase II study</article-title>. <source>Cancer Invest.</source> <volume>28</volume>, <fpage>820</fpage>–<lpage>827</lpage><pub-id pub-id-type="doi">10.3109/07357901003630926</pub-id><pub-id pub-id-type="pmid">20482249</pub-id></mixed-citation></ref><ref id="B114"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ozgur</surname><given-names>E.</given-names></name><name><surname>Güler</surname><given-names>G.</given-names></name><name><surname>Seyhan</surname><given-names>N.</given-names></name></person-group> (<year>2010</year>). <article-title>Mobile phone radiation-induced free radical damage in the liver is inhibited by the antioxidants N-acetyl cysteine and epigallocatechin-gallate</article-title>. <source>Int. J. Radiat. Biol.</source> <volume>86</volume>, <fpage>935</fpage>–<lpage>945</lpage><pub-id pub-id-type="doi">10.3109/09553002.2010.496029</pub-id><pub-id pub-id-type="pmid">20807176</pub-id></mixed-citation></ref><ref id="B115"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pacheco-Palencia</surname><given-names>L. A.</given-names></name><name><surname>Noratto</surname><given-names>G.</given-names></name><name><surname>Hingorani</surname><given-names>L.</given-names></name><name><surname>Talcott</surname><given-names>S. T.</given-names></name><name><surname>Mertens-Talcott</surname><given-names>S. U.</given-names></name></person-group> (<year>2008</year>). <article-title>Protective effects of standardized pomegranate (<italic>Punica granatum</italic> L.) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts</article-title>. <source>J. Agric. Food Chem.</source> <volume>56</volume>, <fpage>8434</fpage>–<lpage>8441</lpage><pub-id pub-id-type="doi">10.1021/jf8001608</pub-id><pub-id pub-id-type="pmid">18717570</pub-id></mixed-citation></ref><ref id="B116"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Park</surname><given-names>E.</given-names></name><name><surname>Hwang</surname><given-names>I.</given-names></name><name><surname>Song</surname><given-names>J. Y.</given-names></name><name><surname>Jee</surname><given-names>Y.</given-names></name></person-group> (<year>2011</year>). <article-title>Acidic polysaccharide of <italic>Panax ginseng</italic> as a defense against small intestinal damage by whole-body gamma irradiation of mice</article-title>. <source>Acta Histochem.</source> <volume>113</volume>, <fpage>19</fpage>–<lpage>23</lpage><pub-id pub-id-type="doi">10.1016/j.acthis.2009.07.003</pub-id><pub-id pub-id-type="pmid">19767060</pub-id></mixed-citation></ref><ref id="B117"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Park</surname><given-names>H. R.</given-names></name><name><surname>Ju</surname><given-names>E. J.</given-names></name><name><surname>Jo</surname><given-names>S. K.</given-names></name><name><surname>Jung</surname><given-names>U.</given-names></name><name><surname>Kim</surname><given-names>S. H.</given-names></name></person-group> (<year>2010</year>). <article-title>HemoHIM enhances the therapeutic efficacy of ionizing radiation treatment in tumor-bearing mice</article-title>. <source>J. Med. Food</source> <volume>13</volume>, <fpage>47</fpage>–<lpage>53</lpage><pub-id pub-id-type="doi">10.1089/jmf.2009.1359</pub-id><pub-id pub-id-type="pmid">20136435</pub-id></mixed-citation></ref><ref id="B118"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Park</surname><given-names>K.</given-names></name><name><surname>Lee</surname><given-names>J. H.</given-names></name></person-group> (<year>2008</year>). <article-title>Protective effects of resveratrol on UVB-irradiated HaCaT cells through attenuation of the caspase pathway</article-title>. <source>Oncol. Rep.</source> <volume>19</volume>, <fpage>413</fpage>–<lpage>417</lpage><pub-id pub-id-type="pmid">18202789</pub-id></mixed-citation></ref><ref id="B119"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Patt</surname><given-names>H. M.</given-names></name><name><surname>Tyree</surname><given-names>E. B.</given-names></name><name><surname>Straube</surname><given-names>R. L.</given-names></name><name><surname>Smith</surname><given-names>D. E.</given-names></name></person-group> (<year>1949</year>). <article-title>Cysteine protection against X-irradiation</article-title>. <source>Science</source> <volume>110</volume>, <fpage>213</fpage>–<lpage>214</lpage><pub-id pub-id-type="doi">10.1126/science.110.2852.213</pub-id><pub-id pub-id-type="pmid">17811258</pub-id></mixed-citation></ref><ref id="B120"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Prasad</surname><given-names>K. N.</given-names></name></person-group> (<year>2005</year>). <article-title>Rationale for using multiple antioxidants in protecting humans against low doses of ionizing radiation</article-title>. <source>Br. J. Radiol.</source> <volume>78</volume>, <fpage>485</fpage>–<lpage>492</lpage><pub-id pub-id-type="doi">10.1259/bjr/87552880</pub-id><pub-id pub-id-type="pmid">15900053</pub-id></mixed-citation></ref><ref id="B121"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Prasad</surname><given-names>K. N.</given-names></name><name><surname>Cole</surname><given-names>W. C.</given-names></name></person-group> (<year>2006</year>). <article-title>Antioxidants in cancer therapy</article-title>. <source>J. Clin. Oncol.</source> <volume>24</volume>, <fpage>e8</fpage>–<lpage>e9</lpage><pub-id pub-id-type="doi">10.1200/JCO.2005.04.1327</pub-id><pub-id pub-id-type="pmid">16484690</pub-id></mixed-citation></ref><ref id="B122"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Raffoul</surname><given-names>J. J.</given-names></name><name><surname>Banerjee</surname><given-names>S.</given-names></name><name><surname>Che</surname><given-names>M.</given-names></name><name><surname>Knoll</surname><given-names>Z. E.</given-names></name><name><surname>Doerge</surname><given-names>D. R.</given-names></name><name><surname>Abrams</surname><given-names>J.</given-names></name><name><surname>Kucuk</surname><given-names>O.</given-names></name><name><surname>Sarkar</surname><given-names>F. H.</given-names></name><name><surname>Hillman</surname><given-names>G. G.</given-names></name></person-group> (<year>2007</year>). <article-title>Soy isoflavones enhance radiotherapy in a metastatic prostate cancer model</article-title>. <source>Int. J. Cancer</source> <volume>120</volume>, <fpage>2491</fpage>–<lpage>2498</lpage><pub-id pub-id-type="doi">10.1002/ijc.22548</pub-id><pub-id pub-id-type="pmid">17304503</pub-id></mixed-citation></ref><ref id="B123"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Raffoul</surname><given-names>J. J.</given-names></name><name><surname>Wang</surname><given-names>Y.</given-names></name><name><surname>Kucuk</surname><given-names>O.</given-names></name><name><surname>Forman</surname><given-names>J. D.</given-names></name><name><surname>Sarkar</surname><given-names>F. H.</given-names></name><name><surname>Hillman</surname><given-names>G. G.</given-names></name></person-group> (<year>2006</year>). <article-title>Genistein inhibits radiation-induced activation of NF-kappa B in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest</article-title>. <source>BMC Cancer</source> <volume>6</volume>, <fpage>107</fpage><pub-id pub-id-type="doi">10.1186/1471-2407-6-107</pub-id><pub-id pub-id-type="pmid">16640785</pub-id></mixed-citation></ref><ref id="B124"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Raju</surname><given-names>U.</given-names></name><name><surname>Ariga</surname><given-names>H.</given-names></name><name><surname>Koto</surname><given-names>M.</given-names></name><name><surname>Lu</surname><given-names>X.</given-names></name><name><surname>Pickett</surname><given-names>J.</given-names></name><name><surname>Valdecanas</surname><given-names>D.</given-names></name><name><surname>Mason</surname><given-names>K. A.</given-names></name><name><surname>Milas</surname><given-names>L.</given-names></name></person-group> (<year>2006</year>). <article-title>Improvement of esophageal adenocarcinoma cell and xenograft responses to radiation by targeting cyclin-dependent kinases</article-title>. <source>Radiother. Oncol.</source> <volume>80</volume>, <fpage>185</fpage>–<lpage>191</lpage><pub-id pub-id-type="doi">10.1016/j.radonc.2006.07.027</pub-id><pub-id pub-id-type="pmid">16905211</pub-id></mixed-citation></ref><ref id="B125"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rao</surname><given-names>B. N.</given-names></name><name><surname>Archana</surname><given-names>P. R.</given-names></name><name><surname>Aithal</surname><given-names>B. K.</given-names></name><name><surname>Rao</surname><given-names>B. S.</given-names></name></person-group> (<year>2011</year>). <article-title>Protective effect of zingerone, a dietary compound against radiation induced genetic damage and apoptosis in human lymphocytes</article-title>. <source>Eur. J. Pharmacol.</source> <volume>657</volume>, <fpage>59</fpage>–<lpage>66</lpage><pub-id pub-id-type="doi">10.1016/j.ejphar.2011.02.002</pub-id><pub-id pub-id-type="pmid">21335001</pub-id></mixed-citation></ref><ref id="B126"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rao</surname><given-names>B. N.</given-names></name><name><surname>Rao</surname><given-names>B. S.</given-names></name></person-group> (<year>2010a</year>). <article-title>Antagonistic effects of Zingerone, a phenolic alkanone against radiation-induced cytotoxicity, genotoxicity, apoptosis and oxidative stress in Chinese hamster lung fibroblast cells growing in vitro</article-title>. <source>Mutagenesis</source> <volume>25</volume>, <fpage>577</fpage>–<lpage>587</lpage><pub-id pub-id-type="doi">10.1093/mutage/geq043</pub-id><pub-id pub-id-type="pmid">20713432</pub-id></mixed-citation></ref><ref id="B127"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rao</surname><given-names>B. N.</given-names></name><name><surname>Rao</surname><given-names>B. S.</given-names></name><name><surname>Aithal</surname><given-names>B. K.</given-names></name><name><surname>Kumar</surname><given-names>M. R.</given-names></name></person-group> (<year>2009</year>). <article-title>Radiomodifying and anticlastogenic effect of Zingerone on Swiss albino mice exposed to whole body gamma radiation</article-title>. <source>Mutat. Res.</source> <volume>677</volume>, <fpage>33</fpage>–<lpage>41</lpage><pub-id pub-id-type="pmid">19463966</pub-id></mixed-citation></ref><ref id="B128"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rao</surname><given-names>S. K.</given-names></name><name><surname>Rao</surname><given-names>P. S.</given-names></name></person-group> (<year>2010b</year>). <article-title>Alteration in the radiosensitivity of HeLa cells by dichloromethane extract of guduchi (<italic>Tinospora cordifolia</italic>)</article-title>. <source>Integr. Cancer Ther.</source> <volume>9</volume>, <fpage>378</fpage>–<lpage>384</lpage><pub-id pub-id-type="doi">10.1177/1534735410387598</pub-id><pub-id pub-id-type="pmid">21106617</pub-id></mixed-citation></ref><ref id="B129"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rigano</surname><given-names>D.</given-names></name><name><surname>Cardile</surname><given-names>V.</given-names></name><name><surname>Formisano</surname><given-names>C.</given-names></name><name><surname>Maldini</surname><given-names>M. T.</given-names></name><name><surname>Piacente</surname><given-names>S.</given-names></name><name><surname>Bevelacqua</surname><given-names>Y.</given-names></name><name><surname>Russo</surname><given-names>A.</given-names></name><name><surname>Senatore</surname><given-names>F.</given-names></name></person-group> (<year>2009</year>). <article-title><italic>Genista sessilifolia</italic> DC. and Genista tinctoria L. inhibit UV light and nitric oxide-induced DNA damage and human melanoma cell growth</article-title>. <source>Chem. Biol. Interact.</source> <volume>180</volume>, <fpage>211</fpage>–<lpage>219</lpage><pub-id pub-id-type="doi">10.1016/j.cbi.2009.02.010</pub-id><pub-id pub-id-type="pmid">19497419</pub-id></mixed-citation></ref><ref id="B130"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rosenberg</surname><given-names>A.</given-names></name><name><surname>Knox</surname><given-names>S.</given-names></name></person-group> (<year>2006</year>). <article-title>Radiation sensitization with redox modulators: a promising approach</article-title>. <source>Int. J. Radiat. Oncol. Biol. Phys.</source> <volume>64</volume>, <fpage>343</fpage>–<lpage>354</lpage><pub-id pub-id-type="doi">10.1016/j.ijrobp.2005.10.013</pub-id><pub-id pub-id-type="pmid">16414370</pub-id></mixed-citation></ref><ref id="B131"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Roy</surname><given-names>P.</given-names></name><name><surname>Madan</surname><given-names>E.</given-names></name><name><surname>Kalra</surname><given-names>N.</given-names></name><name><surname>Nigam</surname><given-names>N.</given-names></name><name><surname>George</surname><given-names>J.</given-names></name><name><surname>Ray</surname><given-names>R. S.</given-names></name><name><surname>Hans</surname><given-names>R. K.</given-names></name><name><surname>Prasad</surname><given-names>S.</given-names></name><name><surname>Shukla</surname><given-names>Y.</given-names></name></person-group> (<year>2009</year>). <article-title>Resveratrol enhances ultraviolet B-induced cell death through nuclear factor-kappaB pathway in human epidermoid carcinoma A431 cells</article-title>. <source>Biochem. Biophys. Res. Commun.</source> <volume>384</volume>, <fpage>215</fpage>–<lpage>220</lpage><pub-id pub-id-type="doi">10.1016/j.bbrc.2009.04.100</pub-id><pub-id pub-id-type="pmid">19397895</pub-id></mixed-citation></ref><ref id="B132"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Samarth</surname><given-names>R. M.</given-names></name></person-group> (<year>2007</year>). <article-title>Protection against radiation induced hematopoietic damage in bone marrow of Swiss albino mice by <italic>Mentha piperita</italic> (Linn)</article-title>. <source>J. Radiat. Res.</source> <volume>48</volume>, <fpage>523</fpage>–<lpage>528</lpage><pub-id pub-id-type="doi">10.1269/jrr.07052</pub-id><pub-id pub-id-type="pmid">17938557</pub-id></mixed-citation></ref><ref id="B133"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sandhya</surname><given-names>T.</given-names></name><name><surname>Lathika</surname><given-names>K. M.</given-names></name><name><surname>Pandey</surname><given-names>B. N.</given-names></name><name><surname>Bhilwade</surname><given-names>H. N.</given-names></name><name><surname>Chaubey</surname><given-names>R. C.</given-names></name><name><surname>Priyadarsini</surname><given-names>K. I.</given-names></name><name><surname>Mishra</surname><given-names>K. P.</given-names></name></person-group> (<year>2006</year>). <article-title>Protection against radiation oxidative damage in mice by Triphala</article-title>. <source>Mutat. Res.</source> <volume>609</volume>, <fpage>17</fpage>–<lpage>25</lpage><pub-id pub-id-type="pmid">16860592</pub-id></mixed-citation></ref><ref id="B134"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sato</surname><given-names>T.</given-names></name><name><surname>Kokuba</surname><given-names>Y.</given-names></name><name><surname>Koizumi</surname><given-names>W.</given-names></name><name><surname>Hayakawa</surname><given-names>K.</given-names></name><name><surname>Okayasu</surname><given-names>I.</given-names></name><name><surname>Watanabe</surname><given-names>M.</given-names></name></person-group> (<year>2007</year>). <article-title>Phase I trial of neoadjuvant preoperative chemotherapy with S-1 and irinotecan plus radiation in patients with locally advanced rectal cancer</article-title>. <source>Int. J. Radiat. Oncol. Biol. Phys.</source> <volume>69</volume>, <fpage>1442</fpage>–<lpage>1447</lpage><pub-id pub-id-type="doi">10.1016/j.ijrobp.2007.05.081</pub-id><pub-id pub-id-type="pmid">17855009</pub-id></mixed-citation></ref><ref id="B135"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Scarlatti</surname><given-names>F.</given-names></name><name><surname>Sala</surname><given-names>G.</given-names></name><name><surname>Ricci</surname><given-names>C.</given-names></name><name><surname>Maioli</surname><given-names>C.</given-names></name><name><surname>Milani</surname><given-names>F.</given-names></name><name><surname>Minella</surname><given-names>M.</given-names></name><name><surname>Botturi</surname><given-names>M.</given-names></name><name><surname>Ghidoni</surname><given-names>R.</given-names></name></person-group> (<year>2007</year>). <article-title>Resveratrol sensitization of DU145 prostate cancer cells to ionizing radiation is associated to ceramide increase</article-title>. <source>Cancer Lett.</source> <volume>253</volume>, <fpage>124</fpage>–<lpage>130</lpage><pub-id pub-id-type="doi">10.1016/j.canlet.2007.01.014</pub-id><pub-id pub-id-type="pmid">17321671</pub-id></mixed-citation></ref><ref id="B136"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schwarzenberger</surname><given-names>P.</given-names></name><name><surname>Fariss</surname><given-names>A.</given-names></name><name><surname>Linares</surname><given-names>L.</given-names></name><name><surname>Nedzi</surname><given-names>L.</given-names></name><name><surname>Salazar</surname><given-names>O. M.</given-names></name></person-group> (<year>2011</year>). <article-title>Dose escalation of once weekly oral vinorelbine concurrent with weekly split dose hypofractionated chest radiation for palliation of advanced non-small cell lung cancer: a phase I/II study</article-title>. <source>Am. J. Med. Sci.</source> <volume>341</volume>, <fpage>454</fpage>–<lpage>459</lpage><pub-id pub-id-type="doi">10.1097/MAJ.0b013e3182127b3f</pub-id><pub-id pub-id-type="pmid">21613934</pub-id></mixed-citation></ref><ref id="B137"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sharma</surname><given-names>K. V.</given-names></name><name><surname>Sisodia</surname><given-names>R.</given-names></name></person-group> (<year>2009</year>). <article-title>Evaluation of the free radical scavenging activity and radioprotective efficacy of <italic>Grewia asiatica</italic> fruit</article-title>. <source>J. Radiol. Prot.</source> <volume>29</volume>, <fpage>429</fpage>–<lpage>443</lpage><pub-id pub-id-type="doi">10.1088/0952-4746/29/3/007</pub-id><pub-id pub-id-type="pmid">19690357</pub-id></mixed-citation></ref><ref id="B138"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sharma</surname><given-names>P.</given-names></name><name><surname>Parmar</surname><given-names>J.</given-names></name><name><surname>Sharma</surname><given-names>P.</given-names></name><name><surname>Verma</surname><given-names>P.</given-names></name><name><surname>Goyal</surname><given-names>P. K.</given-names></name></person-group> (<year>2011</year>). <article-title>Radiation-induced testicular injury and its amelioration by <italic>Tinospora cordifolia</italic> (An Indian Medicinal Plant) Extract</article-title>. <source>Evid. Based Complement. Alternat. Med.</source> <volume>2011</volume>, <fpage>643847</fpage><pub-id pub-id-type="doi">10.1093/ecam/nep233</pub-id><pub-id pub-id-type="pmid">21350610</pub-id></mixed-citation></ref><ref id="B139"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sheehan</surname><given-names>J.</given-names></name><name><surname>Ionescu</surname><given-names>A.</given-names></name><name><surname>Pouratian</surname><given-names>N.</given-names></name><name><surname>Hamilton</surname><given-names>D. K.</given-names></name><name><surname>Schlesinger</surname><given-names>D.</given-names></name><name><surname>Oskouian</surname><given-names>R. J.</given-names><suffix>Jr.</suffix></name><name><surname>Sansur</surname><given-names>C.</given-names></name></person-group> (<year>2008</year>). <article-title>Use of trans sodium crocetinate for sensitizing glioblastoma multiforme to radiation: laboratory investigation</article-title>. <source>J. Neurosurg.</source> <volume>108</volume>, <fpage>972</fpage>–<lpage>978</lpage><pub-id pub-id-type="doi">10.3171/JNS/2008/108/5/0972</pub-id><pub-id pub-id-type="pmid">18447715</pub-id></mixed-citation></ref><ref id="B140"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shimada</surname><given-names>M.</given-names></name><name><surname>Kato</surname><given-names>A.</given-names></name><name><surname>Habu</surname><given-names>T.</given-names></name><name><surname>Komatsu</surname><given-names>K.</given-names></name></person-group> (<year>2011</year>). <article-title>Genistein, isoflavonoids in soybeans, prevents the formation of excess radiation-induced centrosomes via p21 up-regulation</article-title>. <source>Mutat Res.</source> <volume>716</volume>, <fpage>27</fpage>–<lpage>32</lpage><pub-id pub-id-type="doi">10.1016/j.mrfmmm.2011.07.017</pub-id><pub-id pub-id-type="pmid">21843532</pub-id></mixed-citation></ref><ref id="B141"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shin</surname><given-names>J. I.</given-names></name><name><surname>Shim</surname><given-names>J. H.</given-names></name><name><surname>Kim</surname><given-names>K. H</given-names></name><name><surname>Choi</surname><given-names>H. S.</given-names></name><name><surname>Kim</surname><given-names>J. W.</given-names></name><name><surname>Lee</surname><given-names>H. G.</given-names></name><name><surname>Kim</surname><given-names>B. Y.</given-names></name><name><surname>Park</surname><given-names>S. N.</given-names></name><name><surname>Park</surname><given-names>O. J.</given-names></name><name><surname>Yoon</surname><given-names>D. Y.</given-names></name></person-group> (<year>2008</year>). <article-title>Sensitization of the apoptotic effect of gamma-irradiation in genistein-pretreated CaSki cervical cancer cells</article-title>. <source>J. Microbiol. Biotechnol.</source> <volume>18</volume>, <fpage>523</fpage>–<lpage>531</lpage><pub-id pub-id-type="pmid">18388472</pub-id></mixed-citation></ref><ref id="B142"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shin</surname><given-names>S. J.</given-names></name><name><surname>Kim</surname><given-names>N. K.</given-names></name><name><surname>Keum</surname><given-names>K. C.</given-names></name><name><surname>Kim</surname><given-names>H. G.</given-names></name><name><surname>Im</surname><given-names>J. S.</given-names></name><name><surname>Choi</surname><given-names>H. J.</given-names></name><name><surname>Baik</surname><given-names>S. H.</given-names></name><name><surname>Choen</surname><given-names>J. H.</given-names></name><name><surname>Jeung</surname><given-names>H. C.</given-names></name><name><surname>Rha</surname><given-names>S. Y.</given-names></name><name><surname>Roh</surname><given-names>J. K.</given-names></name><name><surname>Chung</surname><given-names>H. C.</given-names></name><name><surname>Ahn</surname><given-names>J. B.</given-names></name></person-group> (<year>2010</year>). <article-title>Phase II study of preoperative chemoradiotherapy (CRT) with irinotecan plus S-1 in locally advanced rectal cancer</article-title>. <source>Radiother. Oncol.</source> <volume>95</volume>, <fpage>303</fpage>–<lpage>307</lpage><pub-id pub-id-type="doi">10.1016/j.radonc.2010.02.003</pub-id><pub-id pub-id-type="pmid">20211505</pub-id></mixed-citation></ref><ref id="B143"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Simone</surname><given-names>C. B.</given-names></name><name><surname>Simone</surname><given-names>N. L.</given-names></name><name><surname>Simone</surname><given-names>V.</given-names></name><name><surname>Simone</surname><given-names>C. B.</given-names></name></person-group> (<year>2007</year>). <article-title>Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, Part 2</article-title>. <source>Altern. Ther. Health Med.</source> <volume>13</volume>, <fpage>40</fpage>–<lpage>47</lpage><pub-id pub-id-type="pmid">17405678</pub-id></mixed-citation></ref><ref id="B144"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Singh-Gupta</surname><given-names>V.</given-names></name><name><surname>Zhang</surname><given-names>H.</given-names></name><name><surname>Yunker</surname><given-names>C. K.</given-names></name><name><surname>Ahmad</surname><given-names>Z.</given-names></name><name><surname>Zwier</surname><given-names>D.</given-names></name><name><surname>Sarkar</surname><given-names>F. H.</given-names></name><name><surname>Hillman</surname><given-names>G. G.</given-names></name></person-group> (<year>2010</year>). <article-title>Daidzein effect on hormone refractory prostate cancer in vitro and in vivo compared to genistein and soy extract: potentiation of radiotherapy</article-title>. <source>Pharm. Res.</source> <volume>27</volume>, <fpage>1115</fpage>–<lpage>1127</lpage><pub-id pub-id-type="doi">10.1007/s11095-010-0107-9</pub-id><pub-id pub-id-type="pmid">20309614</pub-id></mixed-citation></ref><ref id="B145"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sinha</surname><given-names>M.</given-names></name><name><surname>Das</surname><given-names>D. K.</given-names></name><name><surname>Bhattacharjee</surname><given-names>S.</given-names></name><name><surname>Majumdar</surname><given-names>S.</given-names></name><name><surname>Dey</surname><given-names>S.</given-names></name></person-group> (<year>2011</year>). <article-title>Leaf extract of <italic>Moringa oleifera</italic> prevents ionizing radiation-induced oxidative stress in mice</article-title>. <source>J. Med. Food</source> <volume>14</volume>, <fpage>1167</fpage>–<lpage>1172</lpage><pub-id pub-id-type="doi">10.1089/jmf.2010.1506</pub-id><pub-id pub-id-type="pmid">21861723</pub-id></mixed-citation></ref><ref id="B146"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sisodia</surname><given-names>R.</given-names></name><name><surname>Singh</surname><given-names>S.</given-names></name><name><surname>Sharma</surname><given-names>K. V.</given-names></name><name><surname>Ahaskar</surname><given-names>M.</given-names></name></person-group> (<year>2008</year>). <article-title>Post treatment effect of <italic>Grewia asiatica</italic> against radiation-induced biochemical alterations in Swiss albino mice</article-title>. <source>J. Environ. Pathol. Toxicol. Oncol.</source> <volume>27</volume>, <fpage>113</fpage>–<lpage>121</lpage><pub-id pub-id-type="pmid">18540847</pub-id></mixed-citation></ref><ref id="B147"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Son</surname><given-names>E. W.</given-names></name><name><surname>Mo</surname><given-names>S. J.</given-names></name><name><surname>Rhee</surname><given-names>D. K.</given-names></name><name><surname>Pyo</surname><given-names>S.</given-names></name></person-group> (<year>2006</year>). <article-title>Inhibition of ICAM-1 expression by garlic component, allicin, in gamma-irradiated human vascular endothelial cells via downregulation of the JNK signaling pathway</article-title>. <source>Int. Immunopharmacol.</source> <volume>6</volume>, <fpage>1788</fpage>–<lpage>1795</lpage><pub-id pub-id-type="doi">10.1016/j.intimp.2006.07.021</pub-id><pub-id pub-id-type="pmid">17052669</pub-id></mixed-citation></ref><ref id="B148"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Srinivasan</surname><given-names>M.</given-names></name><name><surname>Rajendra</surname><given-names>P. N.</given-names></name><name><surname>Menon</surname><given-names>V. P.</given-names></name></person-group> (<year>2006</year>). <article-title>Protective effect of curcumin on gamma-radiation induced DNA damage and lipid peroxidation in cultured human lymphocytes</article-title>. <source>Mutat. Res.</source> <volume>611</volume>, <fpage>96</fpage>–<lpage>103</lpage><pub-id pub-id-type="pmid">16973408</pub-id></mixed-citation></ref><ref id="B149"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Staniforth</surname><given-names>V.</given-names></name><name><surname>Huang</surname><given-names>W. C.</given-names></name><name><surname>Aravindaram</surname><given-names>K.</given-names></name><name><surname>Yang</surname><given-names>N. S.</given-names></name></person-group> (<year>2011</year>). <article-title>Ferulic acid, a phenolic phytochemical, inhibits UVB-induced matrix metalloproteinases in mouse skin via posttranslational mechanisms</article-title>. <source>J. Nutr. Biochem.</source> [Epub ahead of print].<pub-id pub-id-type="pmid">21543204</pub-id></mixed-citation></ref><ref id="B150"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stone</surname><given-names>H. B.</given-names></name><name><surname>Coleman</surname><given-names>C. N.</given-names></name><name><surname>Anscher</surname><given-names>M. S.</given-names></name><name><surname>McBride</surname><given-names>W. H.</given-names></name></person-group> (<year>2003</year>). <article-title>Effects of radiation on normal tissue: consequences and mechanisms</article-title>. <source>Lancet Oncol.</source> <volume>4</volume>, <fpage>529</fpage>–<lpage>536</lpage><pub-id pub-id-type="doi">10.1016/S1470-2045(03)01191-4</pub-id><pub-id pub-id-type="pmid">12965273</pub-id></mixed-citation></ref><ref id="B151"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Suresh</surname><given-names>K.</given-names></name><name><surname>Vasudevan</surname><given-names>D. M.</given-names></name></person-group> (<year>1994</year>). <article-title>Augmentation of murine natural killer cell and antibody dependent cellular cytotoxicity activities by Phyllanthus emblica, a new immunomodulator</article-title>. <source>J. Ethnopharmacol.</source> <volume>44</volume>, <fpage>55</fpage>–<lpage>60</lpage><pub-id pub-id-type="doi">10.1016/0378-8741(94)90099-X</pub-id><pub-id pub-id-type="pmid">7990505</pub-id></mixed-citation></ref><ref id="B152"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Suzuki</surname><given-names>M.</given-names></name><name><surname>Amano</surname><given-names>M.</given-names></name><name><surname>Choi</surname><given-names>J.</given-names></name><name><surname>Park</surname><given-names>H. J.</given-names></name><name><surname>Williams</surname><given-names>B. W.</given-names></name><name><surname>Ono</surname><given-names>K.</given-names></name><name><surname>Song</surname><given-names>C. W.</given-names></name></person-group> (<year>2006</year>). <article-title>Synergistic effects of radiation and beta-lapachone in DU-145 human prostate cancer cells in vitro</article-title>. <source>Radiat. Res.</source> <volume>165</volume>, <fpage>525</fpage>–<lpage>531</lpage><pub-id pub-id-type="doi">10.1667/RR3542.1</pub-id><pub-id pub-id-type="pmid">16669706</pub-id></mixed-citation></ref><ref id="B153"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Svobodová</surname><given-names>A.</given-names></name><name><surname>Zdarilová</surname><given-names>A.</given-names></name><name><surname>Malisková</surname><given-names>J.</given-names></name><name><surname>Mikulková</surname><given-names>H.</given-names></name><name><surname>Walterová</surname><given-names>D.</given-names></name><name><surname>Vostalová</surname><given-names>J.</given-names></name></person-group> (<year>2007</year>). <article-title>Attenuation of UVA-induced damage to human keratinocytes by silymarin</article-title>. <source>J. Dermatol. Sci.</source> <volume>46</volume>, <fpage>21</fpage>–<lpage>30</lpage><pub-id pub-id-type="doi">10.1016/j.jdermsci.2006.12.009</pub-id><pub-id pub-id-type="pmid">17289350</pub-id></mixed-citation></ref><ref id="B154"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Szatrowski</surname><given-names>T. P.</given-names></name><name><surname>Nathan</surname><given-names>C. F.</given-names></name></person-group> (<year>1991</year>). <article-title>Production of large amounts of hydrogen peroxide by human tumor cells</article-title>. <source>Cancer Res.</source> <volume>51</volume>, <fpage>794</fpage>–<lpage>798</lpage><pub-id pub-id-type="pmid">1846317</pub-id></mixed-citation></ref><ref id="B155"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Toyokuni</surname><given-names>S.</given-names></name><name><surname>Okamoto</surname><given-names>K.</given-names></name><name><surname>Yodoi</surname><given-names>J.</given-names></name><name><surname>Hiai</surname><given-names>H.</given-names></name></person-group> (<year>1995</year>). <article-title>Persistent oxidative stress in cancer</article-title>. <source>FEBS Lett.</source> <volume>358</volume>, <fpage>1</fpage>–<lpage>3</lpage><pub-id pub-id-type="doi">10.1016/0014-5793(94)01368-B</pub-id><pub-id pub-id-type="pmid">7821417</pub-id></mixed-citation></ref><ref id="B156"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Uma Devi</surname><given-names>P.</given-names></name><name><surname>Utsumiz</surname><given-names>H.</given-names></name><name><surname>Takata</surname><given-names>M.</given-names></name><name><surname>Takeda</surname><given-names>S.</given-names></name></person-group> (<year>2008</year>). <article-title>Enhancement of radiation induced cell death in chicken B lymphocytes by withaferin A</article-title>. <source>Indian J. Exp. Biol.</source> <volume>46</volume>, <fpage>437</fpage>–<lpage>442</lpage><pub-id pub-id-type="pmid">18697601</pub-id></mixed-citation></ref><ref id="B157"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Vaid</surname><given-names>M.</given-names></name><name><surname>Katiyar</surname><given-names>S. K.</given-names></name></person-group> (<year>2010</year>). <article-title>Molecular mechanisms of inhibition of photocarcinogenesis by silymarin, a phytoch<italic>e</italic>mical from milk thistle (<italic>Silybum marianum</italic> L. Gaertn.)</article-title>. <source>Int. J. Oncol.</source> <volume>36</volume>, <fpage>1053</fpage>–<lpage>1060</lpage><pub-id pub-id-type="pmid">20372777</pub-id></mixed-citation></ref><ref id="B158"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Veeraraghavan</surname><given-names>J.</given-names></name><name><surname>Aravindan</surname><given-names>S.</given-names></name><name><surname>Natarajan</surname><given-names>M.</given-names></name><name><surname>Awasthi</surname><given-names>V.</given-names></name><name><surname>Herman</surname><given-names>T. S.</given-names></name><name><surname>Aravindan</surname><given-names>N.</given-names></name></person-group> (<year>2011</year>). <article-title>Neem leaf extract induces radiosensitization in human neuroblastoma xenograft through modulation of apoptotic pathway</article-title>. <source>Anticancer Res.</source> <volume>31</volume>, <fpage>161</fpage>–<lpage>170</lpage><pub-id pub-id-type="pmid">21273594</pub-id></mixed-citation></ref><ref id="B159"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Venkatachalam</surname><given-names>S. R.</given-names></name><name><surname>Chattopadhyay</surname><given-names>S.</given-names></name></person-group> (<year>2005</year>). <article-title>Natural radioprotective agents: an overview</article-title>, <source>Curr. Org. Chem.</source> <volume>9</volume>, <fpage>389</fpage>–<lpage>404</lpage><pub-id pub-id-type="doi">10.2174/1385272053174930</pub-id></mixed-citation></ref><ref id="B160"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Verma</surname><given-names>S.</given-names></name><name><surname>Younus</surname><given-names>J.</given-names></name><name><surname>Stys-Norman</surname><given-names>D.</given-names></name><name><surname>Haynes</surname><given-names>A. E.</given-names></name><name><surname>Blackstein</surname><given-names>M.</given-names></name></person-group> (<year>2007</year>). <article-title>Ifosfamide-based combination chemotherapy in advanced soft-tissue sarcoma: a practice guideline</article-title>. <source>Curr. Oncol.</source> <volume>14</volume>, <fpage>144</fpage>–<lpage>148</lpage><pub-id pub-id-type="doi">10.3747/co.2007.153</pub-id><pub-id pub-id-type="pmid">17710206</pub-id></mixed-citation></ref><ref id="B161"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>Y. N.</given-names></name><name><surname>Wu</surname><given-names>W.</given-names></name><name><surname>Chen</surname><given-names>H. C.</given-names></name><name><surname>Fang</surname><given-names>H.</given-names></name></person-group> (<year>2010</year>). <article-title>Genistein protects against UVB-induced senescence-like characteristics in human dermal fibroblast by p66Shc down-regulation</article-title>. <source>J. Dermatol. Sci.</source> <volume>58</volume>, <fpage>19</fpage>–<lpage>27</lpage><pub-id pub-id-type="doi">10.1016/j.jdermsci.2010.03.021</pub-id><pub-id pub-id-type="pmid">20211546</pub-id></mixed-citation></ref><ref id="B162"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Weiss</surname><given-names>J. F.</given-names></name><name><surname>Landauer</surname><given-names>M. R.</given-names></name></person-group> (<year>2000</year>). <article-title>Radioprotection by antioxidants</article-title>. <source>Ann. N. Y. Acad. Sci.</source> <volume>899</volume>, <fpage>44</fpage>–<lpage>60</lpage><pub-id pub-id-type="doi">10.1111/j.1749-6632.2000.tb06175.x</pub-id><pub-id pub-id-type="pmid">10863528</pub-id></mixed-citation></ref><ref id="B163"><mixed-citation publication-type="book"><collab>World Cancer Report.</collab> (<year>2008</year>). eds <person-group person-group-type="editor"><name><surname>Boyle</surname><given-names>P.</given-names></name><name><surname>Levin</surname><given-names>B. E.</given-names></name></person-group> (<publisher-loc>Lyon</publisher-loc>: <publisher-name>IARC Press</publisher-name>). Available at: <uri xlink:type="simple" xlink:href="http://www.iarc.fr/en/publications/pdfs-online/wcr/2008/wcr_2008.pdf">http://www.iarc.fr/en/publications/pdfs-online/wcr/2008/wcr_2008.pdf</uri></mixed-citation></ref><ref id="B164"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Xie</surname><given-names>C. H.</given-names></name><name><surname>Zhang</surname><given-names>M. S.</given-names></name><name><surname>Zhou</surname><given-names>Y. F.</given-names></name><name><surname>Han</surname><given-names>G.</given-names></name><name><surname>Cao</surname><given-names>Z.</given-names></name><name><surname>Zhou</surname><given-names>F. X.</given-names></name><name><surname>Zhang</surname><given-names>G.</given-names></name><name><surname>Luo</surname><given-names>Z. G.</given-names></name><name><surname>Wu</surname><given-names>J. P.</given-names></name><name><surname>Liu</surname><given-names>H.</given-names></name><name><surname>Chen</surname><given-names>J.</given-names></name><name><surname>Zhang</surname><given-names>W. J.</given-names></name></person-group> (<year>2006</year>). <article-title>Chinese medicine <italic>Angelica sinensis</italic> suppresses radiation-induced expression of TNF-alpha and TGF-beta1 in mice</article-title>. <source>Oncol. Rep.</source> <volume>15</volume>, <fpage>1429</fpage>–<lpage>1436</lpage><pub-id pub-id-type="pmid">16685376</pub-id></mixed-citation></ref><ref id="B165"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yang</surname><given-names>E. S.</given-names></name><name><surname>Choi</surname><given-names>M. J.</given-names></name><name><surname>Kim</surname><given-names>J. H.</given-names></name><name><surname>Choi</surname><given-names>K. S.</given-names></name><name><surname>Kwon</surname><given-names>T. K.</given-names></name></person-group> (<year>2011a</year>). <article-title>Withaferin A enhances radiation-induced apoptosis in Caki cells through induction of reactive oxygen species, Bcl-2 downregulation and Akt inhibition</article-title>. <source>Chem. Biol. Interact.</source> <volume>190</volume>, <fpage>9</fpage>–<lpage>15</lpage><pub-id pub-id-type="doi">10.1016/j.cbi.2011.01.015</pub-id><pub-id pub-id-type="pmid">21256832</pub-id></mixed-citation></ref><ref id="B166"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yang</surname><given-names>E. S.</given-names></name><name><surname>Choi</surname><given-names>M. J.</given-names></name><name><surname>Kim</surname><given-names>J. H.</given-names></name><name><surname>Choi</surname><given-names>K. S.</given-names></name><name><surname>Kwon</surname><given-names>T. K.</given-names></name></person-group> (<year>2011b</year>). <article-title>Combination of withaferin A and X-ray irradiation enhances apoptosis in U937 cells</article-title>. <source>Toxicol. In vitro.</source> <volume>25</volume>, <fpage>1803</fpage>–<lpage>1810</lpage><pub-id pub-id-type="doi">10.1016/j.tiv.2011.02.009</pub-id><pub-id pub-id-type="pmid">21964475</pub-id></mixed-citation></ref><ref id="B167"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yang</surname><given-names>Y. P.</given-names></name><name><surname>Chang</surname><given-names>Y. L.</given-names></name><name><surname>Huang</surname><given-names>P. I.</given-names></name><name><surname>Chiou</surname><given-names>G. Y.</given-names></name><name><surname>Tseng</surname><given-names>L. M.</given-names></name><name><surname>Chiou</surname><given-names>S. H.</given-names></name><name><surname>Chen</surname><given-names>M. H.</given-names></name><name><surname>Chen</surname><given-names>M. T.</given-names></name><name><surname>Shih</surname><given-names>Y. H.</given-names></name><name><surname>Chang</surname><given-names>C. H.</given-names></name><name><surname>Hsu</surname><given-names>C. C.</given-names></name><name><surname>Ma</surname><given-names>H. I.</given-names></name><name><surname>Wang</surname><given-names>C. T.</given-names></name><name><surname>Tsai</surname><given-names>L. L.</given-names></name><name><surname>Yu</surname><given-names>C. C.</given-names></name><name><surname>Chang</surname><given-names>C. J.</given-names></name></person-group> (<year>2011</year>). <article-title>Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis</article-title>. <source>J. Cell. Physiol.</source> [Epub ahead of print].<pub-id pub-id-type="doi">10.1002/jcp.22806</pub-id></mixed-citation></ref><ref id="B168"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yoon</surname><given-names>J. H.</given-names></name><name><surname>Lim</surname><given-names>T. G.</given-names></name><name><surname>Lee</surname><given-names>K. M.</given-names></name><name><surname>Jeon</surname><given-names>A. J.</given-names></name><name><surname>Kim</surname><given-names>S. Y.</given-names></name><name><surname>Lee</surname><given-names>K. W.</given-names></name></person-group> (<year>2011</year>). <article-title>Tangeretin reduces ultraviolet B (UVB)-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking mitogen-activated protein kinase (MAPK) activation and reactive oxygen species (ROS) generation</article-title>. <source>J. Agric. Food Chem.</source> <volume>59</volume>, <fpage>222</fpage>–<lpage>228</lpage><pub-id pub-id-type="doi">10.1021/jf103204x</pub-id><pub-id pub-id-type="pmid">21126077</pub-id></mixed-citation></ref><ref id="B169"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>You</surname><given-names>W. C.</given-names></name><name><surname>Hsieh</surname><given-names>C. C.</given-names></name><name><surname>Huang</surname><given-names>J. T.</given-names></name></person-group> (<year>2009a</year>). <article-title>Effect of extracts from indigowood root (<italic>Isatis indigotica</italic> Fort.) on immune responses in radiation-induced mucositis</article-title>. <source>J. Altern. Complement. Med.</source> <volume>15</volume>, <fpage>771</fpage>–<lpage>778</lpage><pub-id pub-id-type="doi">10.1089/acm.2008.0322</pub-id><pub-id pub-id-type="pmid">19534614</pub-id></mixed-citation></ref><ref id="B170"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>You</surname><given-names>W. C.</given-names></name><name><surname>Lin</surname><given-names>W. C.</given-names></name><name><surname>Huang</surname><given-names>J. T.</given-names></name><name><surname>Hsieh</surname><given-names>C. C.</given-names></name></person-group> (<year>2009b</year>). <article-title>Indigowood root extract protects hematopoietic cells, reduces tissue damage and modulates inflammatory cytokines after total-body irradiation: does Indirubin play a role in radioprotection?</article-title> <source>Phytomedicine</source> <volume>16</volume>, <fpage>1105</fpage>–<lpage>1111</lpage><pub-id pub-id-type="doi">10.1016/j.phymed.2009.05.011</pub-id><pub-id pub-id-type="pmid">19589667</pub-id></mixed-citation></ref><ref id="B171"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yu</surname><given-names>R.</given-names></name><name><surname>Hebbar</surname><given-names>V.</given-names></name><name><surname>Kim</surname><given-names>D. W.</given-names></name><name><surname>Mandlekar</surname><given-names>S.</given-names></name><name><surname>Pezzuto</surname><given-names>J. M.</given-names></name><name><surname>Kong</surname><given-names>A. N.</given-names></name></person-group> (<year>2001</year>). <article-title>Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways</article-title>. <source>Mol. Pharmacol.</source> <volume>60</volume>, <fpage>217</fpage>–<lpage>224</lpage><pub-id pub-id-type="pmid">11408617</pub-id></mixed-citation></ref><ref id="B172"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhao</surname><given-names>Y.</given-names></name><name><surname>Cao</surname><given-names>J.</given-names></name><name><surname>Ma</surname><given-names>H.</given-names></name><name><surname>Liu</surname><given-names>J.</given-names></name></person-group> (<year>1997</year>). <article-title>Apoptosis induced by tea polyphenols in HL-60 cells</article-title>. <source>Cancer Lett.</source> <volume>121</volume>, <fpage>163</fpage>–<lpage>167</lpage><pub-id pub-id-type="doi">10.1016/S0304-3835(97)00348-0</pub-id><pub-id pub-id-type="pmid">9570354</pub-id></mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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