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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The inhibitory effects of 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone on human colon cancer cells</title><author><name sortKey="Qiu, Peiju" sort="Qiu, Peiju" uniqKey="Qiu P" first="Peiju" last="Qiu">Peiju Qiu</name><affiliation><nlm:aff id="A1">Department of Food Science, University of Massachusetts, Amherst, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Marine Drug and Food Institute, Ocean University of China, Qingdao Shandong, China</nlm:aff></affiliation></author><author><name sortKey="Guan, Huashi" sort="Guan, Huashi" uniqKey="Guan H" first="Huashi" last="Guan">Huashi Guan</name><affiliation><nlm:aff id="A2">Marine Drug and Food Institute, Ocean University of China, Qingdao Shandong, China</nlm:aff></affiliation></author><author><name sortKey="Dong, Ping" sort="Dong, Ping" uniqKey="Dong P" first="Ping" last="Dong">Ping Dong</name><affiliation><nlm:aff id="A1">Department of Food Science, University of Massachusetts, Amherst, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Guo, Shanshan" sort="Guo, Shanshan" uniqKey="Guo S" first="Shanshan" last="Guo">Shanshan Guo</name><affiliation><nlm:aff id="A1">Department of Food Science, University of Massachusetts, Amherst, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Zheng, Jinkai" sort="Zheng, Jinkai" uniqKey="Zheng J" first="Jinkai" last="Zheng">Jinkai Zheng</name><affiliation><nlm:aff id="A1">Department of Food Science, University of Massachusetts, Amherst, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Shiming" sort="Li, Shiming" uniqKey="Li S" first="Shiming" last="Li">Shiming Li</name><affiliation><nlm:aff id="A3">Department of Food Science, Rutgers, the State University of New Jersey, New Brunswick, NJ, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Yun" sort="Chen, Yun" uniqKey="Chen Y" first="Yun" last="Chen">Yun Chen</name><affiliation><nlm:aff id="A4">Center for Pharmacogenomics, Washington University, St. Louis, MO, USA</nlm:aff></affiliation></author><author><name sortKey="Ho, Chi Tang" sort="Ho, Chi Tang" uniqKey="Ho C" first="Chi-Tang" last="Ho">Chi-Tang Ho</name><affiliation><nlm:aff id="A3">Department of Food Science, Rutgers, the State University of New Jersey, New Brunswick, NJ, USA</nlm:aff></affiliation></author><author><name sortKey="Pan, Min Hsiung" sort="Pan, Min Hsiung" uniqKey="Pan M" first="Min-Hsiung" last="Pan">Min-Hsiung Pan</name><affiliation><nlm:aff id="A5">Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Mcclements, David Julian" sort="Mcclements, David Julian" uniqKey="Mcclements D" first="David Julian" last="Mcclements">David Julian Mcclements</name><affiliation><nlm:aff id="A1">Department of Food Science, University of Massachusetts, Amherst, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Xiao, Hang" sort="Xiao, Hang" uniqKey="Xiao H" first="Hang" last="Xiao">Hang Xiao</name><affiliation><nlm:aff id="A1">Department of Food Science, University of Massachusetts, Amherst, MA, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21648071</idno><idno type="pmc">3449327</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449327</idno><idno type="RBID">PMC:3449327</idno><idno type="doi">10.1002/mnfr.201100070</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000D65</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The inhibitory effects of 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone on human colon cancer cells</title><author><name sortKey="Qiu, Peiju" sort="Qiu, Peiju" uniqKey="Qiu P" first="Peiju" last="Qiu">Peiju Qiu</name><affiliation><nlm:aff id="A1">Department of Food Science, University of Massachusetts, Amherst, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Marine Drug and Food Institute, Ocean University of China, Qingdao Shandong, China</nlm:aff></affiliation></author><author><name sortKey="Guan, Huashi" sort="Guan, Huashi" uniqKey="Guan H" first="Huashi" last="Guan">Huashi Guan</name><affiliation><nlm:aff id="A2">Marine Drug and Food Institute, Ocean University of China, Qingdao Shandong, China</nlm:aff></affiliation></author><author><name sortKey="Dong, Ping" sort="Dong, Ping" uniqKey="Dong P" first="Ping" last="Dong">Ping Dong</name><affiliation><nlm:aff id="A1">Department of Food Science, University of Massachusetts, Amherst, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Guo, Shanshan" sort="Guo, Shanshan" uniqKey="Guo S" first="Shanshan" last="Guo">Shanshan Guo</name><affiliation><nlm:aff id="A1">Department of Food Science, University of Massachusetts, Amherst, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Zheng, Jinkai" sort="Zheng, Jinkai" uniqKey="Zheng J" first="Jinkai" last="Zheng">Jinkai Zheng</name><affiliation><nlm:aff id="A1">Department of Food Science, University of Massachusetts, Amherst, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Shiming" sort="Li, Shiming" uniqKey="Li S" first="Shiming" last="Li">Shiming Li</name><affiliation><nlm:aff id="A3">Department of Food Science, Rutgers, the State University of New Jersey, New Brunswick, NJ, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Yun" sort="Chen, Yun" uniqKey="Chen Y" first="Yun" last="Chen">Yun Chen</name><affiliation><nlm:aff id="A4">Center for Pharmacogenomics, Washington University, St. Louis, MO, USA</nlm:aff></affiliation></author><author><name sortKey="Ho, Chi Tang" sort="Ho, Chi Tang" uniqKey="Ho C" first="Chi-Tang" last="Ho">Chi-Tang Ho</name><affiliation><nlm:aff id="A3">Department of Food Science, Rutgers, the State University of New Jersey, New Brunswick, NJ, USA</nlm:aff></affiliation></author><author><name sortKey="Pan, Min Hsiung" sort="Pan, Min Hsiung" uniqKey="Pan M" first="Min-Hsiung" last="Pan">Min-Hsiung Pan</name><affiliation><nlm:aff id="A5">Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Mcclements, David Julian" sort="Mcclements, David Julian" uniqKey="Mcclements D" first="David Julian" last="Mcclements">David Julian Mcclements</name><affiliation><nlm:aff id="A1">Department of Food Science, University of Massachusetts, Amherst, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Xiao, Hang" sort="Xiao, Hang" uniqKey="Xiao H" first="Hang" last="Xiao">Hang Xiao</name><affiliation><nlm:aff id="A1">Department of Food Science, University of Massachusetts, Amherst, MA, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Molecular nutrition & food research</title><idno type="ISSN">1613-4125</idno><idno type="eISSN">1613-4133</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Scope</title><p id="P1">Previously, we reported that 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone (5HHMF), a polymethoxyflavone found in citrus peels, potently inhibited the growth of multiple human colon cancer cells. Herein, we further investigated the anti-cancer mechanisms of 5HHMF in human colon cancer cells.</p></sec><sec id="S2"><title>Methods and results</title><p id="P2">Colony formation assay revealed that 5HHMF dose-dependently inhibited colony formation of multiple colon cancer cells. Western blot analysis demonstrated 5HHMF decreased nuclear β-Catenin levels and increased the E-cadherin level in a dose-dependent manner. 5HHMF also modified plasma membrane-associated proteins such as K-Ras, EGFR, and their downstream effectors, such as Akt. Moreover, treatments with 5HHMF inhibited nuclear translocation of NFκB, which may contribute to its anti-cancer effects. Add-back study showed that the inhibitory effect of 5HHMF was not associated with production of reactive oxygen species (ROS). In addition, 5HHMF treatment inhibited the capillary tube formation of human umbilical vein endothelial cells (HUVECs) on matrigel, suggesting a potential anti-tumor angiogenesis effect.</p></sec><sec id="S3"><title>Conclusion</title><p id="P3">our results demonstrated that 5HHMF suppressed multiple oncogenic molecular events in colon cancer cells.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101231818</journal-id><journal-id journal-id-type="pubmed-jr-id">32150</journal-id><journal-id journal-id-type="nlm-ta">Mol Nutr Food Res</journal-id><journal-id journal-id-type="iso-abbrev">Mol Nutr Food Res</journal-id><journal-title-group><journal-title>Molecular nutrition & food research</journal-title></journal-title-group><issn pub-type="ppub">1613-4125</issn><issn pub-type="epub">1613-4133</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21648071</article-id><article-id pub-id-type="pmc">3449327</article-id><article-id pub-id-type="doi">10.1002/mnfr.201100070</article-id><article-id pub-id-type="manuscript">NIHMS391128</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The inhibitory effects of 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone on human colon cancer cells</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Qiu</surname><given-names>Peiju</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Guan</surname><given-names>Huashi</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Dong</surname><given-names>Ping</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Guo</surname><given-names>Shanshan</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Jinkai</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Shiming</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Yun</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Ho</surname><given-names>Chi-Tang</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Pan</surname><given-names>Min-Hsiung</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>McClements</surname><given-names>David Julian</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Xiao</surname><given-names>Hang</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Food Science, University of Massachusetts, Amherst, MA, USA</aff><aff id="A2"><label>2</label>Marine Drug and Food Institute, Ocean University of China, Qingdao Shandong, China</aff><aff id="A3"><label>3</label>Department of Food Science, Rutgers, the State University of New Jersey, New Brunswick, NJ, USA</aff><aff id="A4"><label>4</label>Center for Pharmacogenomics, Washington University, St. Louis, MO, USA</aff><aff id="A5"><label>5</label>Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung, Taiwan</aff><author-notes><corresp id="cor1"><label>*</label><bold>Corresponding Author:</bold> Hang Xiao, Department of Food Science, University of Massachusetts, 100 Holdsworth Way, Amherst, MA 01003, USA, Tel: (413) 545-2281; Fax: (413) 545-1262, <email>hangxiao@foodsci.umass.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>5</day><month>7</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>06</day><month>6</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2012</year></pub-date><volume>55</volume><issue>10</issue><fpage>1523</fpage><lpage>1532</lpage><abstract><sec id="S1"><title>Scope</title><p id="P1">Previously, we reported that 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone (5HHMF), a polymethoxyflavone found in citrus peels, potently inhibited the growth of multiple human colon cancer cells. Herein, we further investigated the anti-cancer mechanisms of 5HHMF in human colon cancer cells.</p></sec><sec id="S2"><title>Methods and results</title><p id="P2">Colony formation assay revealed that 5HHMF dose-dependently inhibited colony formation of multiple colon cancer cells. Western blot analysis demonstrated 5HHMF decreased nuclear β-Catenin levels and increased the E-cadherin level in a dose-dependent manner. 5HHMF also modified plasma membrane-associated proteins such as K-Ras, EGFR, and their downstream effectors, such as Akt. Moreover, treatments with 5HHMF inhibited nuclear translocation of NFκB, which may contribute to its anti-cancer effects. Add-back study showed that the inhibitory effect of 5HHMF was not associated with production of reactive oxygen species (ROS). In addition, 5HHMF treatment inhibited the capillary tube formation of human umbilical vein endothelial cells (HUVECs) on matrigel, suggesting a potential anti-tumor angiogenesis effect.</p></sec><sec id="S3"><title>Conclusion</title><p id="P3">our results demonstrated that 5HHMF suppressed multiple oncogenic molecular events in colon cancer cells.</p></sec></abstract><kwd-group><kwd>5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone</kwd><kwd>colon cancer</kwd><kwd>colony formation</kwd><kwd>EGFR</kwd><kwd>K-RAS</kwd><kwd>β-catenin</kwd><kwd>E-cadherin</kwd><kwd>angiogenesis</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R21 CA139174 || CA</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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