OrangerV1, Pmc, Corpus, bibRecord, 000A65

Natural Products as Aromatase Inhibitors

Identifieur interne : 000A65 ( Pmc/Corpus ); précédent : 000A64; suivant : 000A66

Natural Products as Aromatase Inhibitors

Auteurs : Marcy J. Balunas ; Bin Su ; Robert W. Brueggemeier ; A. Douglas Kinghorn

Source :

Anti-cancer agents in medicinal chemistry [ 1871-5206 ] ; 2008.

RBID : PMC:3074486

Abstract

With the clinical success of several synthetic aromatase inhibitors (AIs) in the treatment of postmenopausal estrogen receptor-positive breast cancer, researchers have also been investigating also the potential of natural products as AIs. Natural products from terrestrial and marine organisms provide a chemically diverse array of compounds not always available through current synthetic chemistry techniques. Natural products that have been used traditionally for nutritional or medicinal purposes (e.g., botanical dietary supplements) may also afford AIs with reduced side effects. A thorough review of the literature regarding natural product extracts and secondary metabolites of plant, microbial, and marine origin that have been shown to exhibit aromatase inhibitory activity is presented herein.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074486

PubMed: 18690828
PubMed Central: 3074486

Links to Exploration step

PMC:3074486

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Natural Products as Aromatase Inhibitors</title>
<author><name sortKey="Balunas, Marcy J" sort="Balunas, Marcy J" uniqKey="Balunas M" first="Marcy J." last="Balunas">Marcy J. Balunas</name>
<affiliation><nlm:aff id="A1">Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 6061, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Su, Bin" sort="Su, Bin" uniqKey="Su B" first="Bin" last="Su">Bin Su</name>
<affiliation><nlm:aff id="A2">Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 4321, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Brueggemeier, Robert W" sort="Brueggemeier, Robert W" uniqKey="Brueggemeier R" first="Robert W." last="Brueggemeier">Robert W. Brueggemeier</name>
<affiliation><nlm:aff id="A2">Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 4321, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kinghorn, A Douglas" sort="Kinghorn, A Douglas" uniqKey="Kinghorn A" first="A. Douglas" last="Kinghorn">A. Douglas Kinghorn</name>
<affiliation><nlm:aff id="A2">Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 4321, USA</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">18690828</idno>
<idno type="pmc">3074486</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074486</idno>
<idno type="RBID">PMC:3074486</idno>
<date when="2008">2008</date>
<idno type="wicri:Area/Pmc/Corpus">000A65</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Natural Products as Aromatase Inhibitors</title>
<author><name sortKey="Balunas, Marcy J" sort="Balunas, Marcy J" uniqKey="Balunas M" first="Marcy J." last="Balunas">Marcy J. Balunas</name>
<affiliation><nlm:aff id="A1">Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 6061, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Su, Bin" sort="Su, Bin" uniqKey="Su B" first="Bin" last="Su">Bin Su</name>
<affiliation><nlm:aff id="A2">Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 4321, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Brueggemeier, Robert W" sort="Brueggemeier, Robert W" uniqKey="Brueggemeier R" first="Robert W." last="Brueggemeier">Robert W. Brueggemeier</name>
<affiliation><nlm:aff id="A2">Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 4321, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kinghorn, A Douglas" sort="Kinghorn, A Douglas" uniqKey="Kinghorn A" first="A. Douglas" last="Kinghorn">A. Douglas Kinghorn</name>
<affiliation><nlm:aff id="A2">Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 4321, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Anti-cancer agents in medicinal chemistry</title>
<idno type="ISSN">1871-5206</idno>
<idno type="eISSN">1875-5992</idno>
<imprint><date when="2008">2008</date>
</imprint>
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<profileDesc><textClass></textClass>
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<front><div type="abstract" xml:lang="en"><p id="P3">With the clinical success of several synthetic aromatase inhibitors (AIs) in the treatment of postmenopausal estrogen receptor-positive breast cancer, researchers have also been investigating also the potential of natural products as AIs. Natural products from terrestrial and marine organisms provide a chemically diverse array of compounds not always available through current synthetic chemistry techniques. Natural products that have been used traditionally for nutritional or medicinal purposes (e.g., botanical dietary supplements) may also afford AIs with reduced side effects. A thorough review of the literature regarding natural product extracts and secondary metabolites of plant, microbial, and marine origin that have been shown to exhibit aromatase inhibitory activity is presented herein.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">101265649</journal-id>
<journal-id journal-id-type="pubmed-jr-id">32766</journal-id>
<journal-id journal-id-type="nlm-ta">Anticancer Agents Med Chem</journal-id>
<journal-title>Anti-cancer agents in medicinal chemistry</journal-title>
<issn pub-type="ppub">1871-5206</issn>
<issn pub-type="epub">1875-5992</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">18690828</article-id>
<article-id pub-id-type="pmc">3074486</article-id>
<article-id pub-id-type="manuscript">NIHMS251665</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Natural Products as Aromatase Inhibitors</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Balunas</surname>
<given-names>Marcy J.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="author-notes" rid="FN1">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Su</surname>
<given-names>Bin</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
<xref ref-type="author-notes" rid="FN2">‡</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brueggemeier</surname>
<given-names>Robert W.</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kinghorn</surname>
<given-names>A. Douglas</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
<xref ref-type="corresp" rid="CR1">*</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>a</label>
Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 6061, USA</aff>
<aff id="A2"><label>b</label>
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 4321, USA</aff>
<author-notes><fn id="FN1" fn-type="present-address"><label>†</label>
<p id="P1">Current address: Smithsonian Tropical Research Institute, Unit 0948, APO, AA 34002.</p>
</fn>
<fn id="FN2"><label>‡</label>
<p id="P2">Current College of Pharmacy, The Ohio State University. address: Beckman Research Institute, City of Hope, Duarte, CA 91010.</p>
</fn>
<corresp id="CR1"><label>*</label>
Address correspondence to this author at the Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA; Tel: +1-614-247-8094. Fax: +1-614-247-8642. <email>kinghorn.4@osu.edu</email>
.</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>17</day>
<month>11</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub"><month>8</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>12</day>
<month>4</month>
<year>2011</year>
</pub-date>
<volume>8</volume>
<issue>6</issue>
<fpage>646</fpage>
<lpage>682</lpage>
<abstract><p id="P3">With the clinical success of several synthetic aromatase inhibitors (AIs) in the treatment of postmenopausal estrogen receptor-positive breast cancer, researchers have also been investigating also the potential of natural products as AIs. Natural products from terrestrial and marine organisms provide a chemically diverse array of compounds not always available through current synthetic chemistry techniques. Natural products that have been used traditionally for nutritional or medicinal purposes (e.g., botanical dietary supplements) may also afford AIs with reduced side effects. A thorough review of the literature regarding natural product extracts and secondary metabolites of plant, microbial, and marine origin that have been shown to exhibit aromatase inhibitory activity is presented herein.</p>
</abstract>
<kwd-group><kwd>aromatase inhibitors</kwd>
<kwd>natural products</kwd>
<kwd>breast cancer</kwd>
<kwd>botanical dietary supplements</kwd>
</kwd-group>
<contract-num rid="CA1">R01 CA073698-08
				||CA</contract-num>
<contract-num rid="CA1">R01 CA073698-06
				||CA</contract-num>
<contract-sponsor id="CA1">National Cancer Institute  : NCI</contract-sponsor>
</article-meta>
</front>
</pmc>
</record>

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Natural Products as Aromatase Inhibitors

Natural Products as Aromatase Inhibitors

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki