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Preliminary In Vitro Antisickilng Properties of Crude Juice Extracts of Persia Americana, Citrus Sinensis, Carica Papaya and Ciklavit®

Identifieur interne : 001002 ( Pmc/Checkpoint ); précédent : 001001; suivant : 001003

Preliminary In Vitro Antisickilng Properties of Crude Juice Extracts of Persia Americana, Citrus Sinensis, Carica Papaya and Ciklavit®

Auteurs : Ee J. Iweala [Nigeria] ; Fo Uhegbu [Nigeria] ; Gn Ogu [Nigeria]

Source :

African Journal of Traditional, Complementary, and Alternative Medicines [ 0189-6016 ] ; 2009.

RBID : PMC:3021153

Abstract

The antisickling properties of crude juice extracts of the edible portions of three commonly consumed tropical fruits namely Persia americana, Citrus sinensis, and Carica papaya were investigated in vitro alongside a new drug preparation called Ciklavit® that has antisickling activity. Four different solvent extracts of the crude juice of each fruit including aqueous, acidic, alkaline and alcoholic extracts were prepared and their antisickling effects on sickle cell trait (HbAS) and sickle cell disease (HbSS) blood samples checked alongside Ciklavit®. Blood samples were stabilized using normal saline and the antisickling effects were checked by counting the number of sickle cells remaining after incubation of the blood samples with the crude fruit extracts and Ciklavit® for twenty-four hours. The results showed that Ciklavit® produced a sustained reduction in the number of sickle cells in both HbAS and HbSS blood samples. Also the alkaline and alcoholic extracts of P. americana and C. papaya produced significant reduction in the number of sickle cells.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021153

PubMed: 21304622
PubMed Central: 3021153

Affiliations:

Nigeria

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PMC:3021153

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Preliminary <italic>In Vitro</italic>
 Antisickilng Properties of Crude Juice Extracts of <italic>Persia Americana, Citrus Sinensis, Carica Papaya</italic>
 and <italic>Ciklavit</italic>
®</title>
<author><name sortKey="Iweala, Ee J" sort="Iweala, Ee J" uniqKey="Iweala E" first="Ee J" last="Iweala">Ee J. Iweala</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Biological Sciences, Covenant University, Ota, Nigeria</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Department of Biological Sciences, Covenant University, Ota</wicri:regionArea>
<wicri:noRegion>Ota</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Uhegbu, Fo" sort="Uhegbu, Fo" uniqKey="Uhegbu F" first="Fo" last="Uhegbu">Fo Uhegbu</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Biochemistry, Abia State University, Uturu, Nigeria</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Department of Biochemistry, Abia State University, Uturu</wicri:regionArea>
<wicri:noRegion>Uturu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ogu, Gn" sort="Ogu, Gn" uniqKey="Ogu G" first="Gn" last="Ogu">Gn Ogu</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Biochemistry, Abia State University, Uturu, Nigeria</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Department of Biochemistry, Abia State University, Uturu</wicri:regionArea>
<wicri:noRegion>Uturu</wicri:noRegion>
</affiliation>
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<idno type="pmc">3021153</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021153</idno>
<idno type="RBID">PMC:3021153</idno>
<date when="2009">2009</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Preliminary <italic>In Vitro</italic>
 Antisickilng Properties of Crude Juice Extracts of <italic>Persia Americana, Citrus Sinensis, Carica Papaya</italic>
 and <italic>Ciklavit</italic>
®</title>
<author><name sortKey="Iweala, Ee J" sort="Iweala, Ee J" uniqKey="Iweala E" first="Ee J" last="Iweala">Ee J. Iweala</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Biological Sciences, Covenant University, Ota, Nigeria</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Department of Biological Sciences, Covenant University, Ota</wicri:regionArea>
<wicri:noRegion>Ota</wicri:noRegion>
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<author><name sortKey="Uhegbu, Fo" sort="Uhegbu, Fo" uniqKey="Uhegbu F" first="Fo" last="Uhegbu">Fo Uhegbu</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Biochemistry, Abia State University, Uturu, Nigeria</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Department of Biochemistry, Abia State University, Uturu</wicri:regionArea>
<wicri:noRegion>Uturu</wicri:noRegion>
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<author><name sortKey="Ogu, Gn" sort="Ogu, Gn" uniqKey="Ogu G" first="Gn" last="Ogu">Gn Ogu</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Biochemistry, Abia State University, Uturu, Nigeria</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Department of Biochemistry, Abia State University, Uturu</wicri:regionArea>
<wicri:noRegion>Uturu</wicri:noRegion>
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<series><title level="j">African Journal of Traditional, Complementary, and Alternative Medicines</title>
<idno type="ISSN">0189-6016</idno>
<idno type="eISSN">0189-6016</idno>
<imprint><date when="2009">2009</date>
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<front><div type="abstract" xml:lang="en"><p>The antisickling properties of crude juice extracts of the edible portions of three commonly consumed tropical fruits namely <italic>Persia americana, Citrus sinensis</italic>
, and <italic>Carica papaya</italic>
 were investigated <italic>in vitro</italic>
 alongside a new drug preparation called <italic>Ciklavit</italic>
® that has antisickling activity. Four different solvent extracts of the crude juice of each fruit including aqueous, acidic, alkaline and alcoholic extracts were prepared and their antisickling effects on sickle cell trait (HbAS) and sickle cell disease (HbSS) blood samples checked alongside <italic>Ciklavit</italic>
®. Blood samples were stabilized using normal saline and the antisickling effects were checked by counting the number of sickle cells remaining after incubation of the blood samples with the crude fruit extracts and <italic>Ciklavit</italic>
® for twenty-four hours. The results showed that <italic>Ciklavit</italic>
® produced a sustained reduction in the number of sickle cells in both HbAS and HbSS blood samples. Also the alkaline and alcoholic extracts of P. americana and <italic>C. papaya</italic>
 produced significant reduction in the number of sickle cells.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Afr J Tradit Complement Altern Med</journal-id>
<journal-title-group><journal-title>African Journal of Traditional, Complementary, and Alternative Medicines</journal-title>
</journal-title-group>
<issn pub-type="ppub">0189-6016</issn>
<issn pub-type="epub">0189-6016</issn>
<publisher><publisher-name>African Networks on Ethnomedicines</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21304622</article-id>
<article-id pub-id-type="pmc">3021153</article-id>
<article-id pub-id-type="publisher-id">jAJT.v7.i2.pg113</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Preliminary <italic>In Vitro</italic>
 Antisickilng Properties of Crude Juice Extracts of <italic>Persia Americana, Citrus Sinensis, Carica Papaya</italic>
 and <italic>Ciklavit</italic>
®</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Iweala</surname>
<given-names>EE J</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Uhegbu</surname>
<given-names>FO</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ogu</surname>
<given-names>GN</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Biological Sciences, Covenant University, Ota, Nigeria</aff>
<aff id="A2"><label>2</label>
Department of Biochemistry, Abia State University, Uturu, Nigeria</aff>
<author-notes><corresp><bold>Email;</bold>
<email>emekaiweala2004@yahoo.co.uk</email>
, <email>emekaiweala@hotmail.com</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>30</day>
<month>12</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="collection"><year>2010</year>
</pub-date>
<volume>7</volume>
<issue>2</issue>
<fpage>113</fpage>
<lpage>117</lpage>
<permissions><copyright-statement>Copyright © Afr. J. Traditional Complementary and Alternative Medicines 2010</copyright-statement>
</permissions>
<abstract abstract-type="executive-summary"><p>The antisickling properties of crude juice extracts of the edible portions of three commonly consumed tropical fruits namely <italic>Persia americana, Citrus sinensis</italic>
, and <italic>Carica papaya</italic>
 were investigated <italic>in vitro</italic>
 alongside a new drug preparation called <italic>Ciklavit</italic>
® that has antisickling activity. Four different solvent extracts of the crude juice of each fruit including aqueous, acidic, alkaline and alcoholic extracts were prepared and their antisickling effects on sickle cell trait (HbAS) and sickle cell disease (HbSS) blood samples checked alongside <italic>Ciklavit</italic>
®. Blood samples were stabilized using normal saline and the antisickling effects were checked by counting the number of sickle cells remaining after incubation of the blood samples with the crude fruit extracts and <italic>Ciklavit</italic>
® for twenty-four hours. The results showed that <italic>Ciklavit</italic>
® produced a sustained reduction in the number of sickle cells in both HbAS and HbSS blood samples. Also the alkaline and alcoholic extracts of P. americana and <italic>C. papaya</italic>
 produced significant reduction in the number of sickle cells.</p>
</abstract>
<kwd-group><kwd>Antisickling</kwd>
<kwd><italic>Ciklavit</italic>
®</kwd>
<kwd><italic>Persia americana</italic>
</kwd>
<kwd><italic>Citrus sinensis</italic>
</kwd>
<kwd><italic>Carica papaya</italic>
</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Nigeria</li>
</country>
</list>
<tree><country name="Nigeria"><noRegion><name sortKey="Iweala, Ee J" sort="Iweala, Ee J" uniqKey="Iweala E" first="Ee J" last="Iweala">Ee J. Iweala</name>
</noRegion>
<name sortKey="Ogu, Gn" sort="Ogu, Gn" uniqKey="Ogu G" first="Gn" last="Ogu">Gn Ogu</name>
<name sortKey="Uhegbu, Fo" sort="Uhegbu, Fo" uniqKey="Uhegbu F" first="Fo" last="Uhegbu">Fo Uhegbu</name>
</country>
</tree>
</affiliations>
</record>

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Preliminary In Vitro Antisickilng Properties of Crude Juice Extracts of Persia Americana, Citrus Sinensis, Carica Papaya and Ciklavit®

Preliminary In Vitro Antisickilng Properties of Crude Juice Extracts of Persia Americana, Citrus Sinensis, Carica Papaya and Ciklavit®

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Abstract

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