Antitumor Activity of Citrus maxima (Burm.) Merr. Leaves in Ehrlich's Ascites Carcinoma Cell-Treated Mice
Identifieur interne : 000E88 ( Pmc/Checkpoint ); précédent : 000E87; suivant : 000E89Antitumor Activity of Citrus maxima (Burm.) Merr. Leaves in Ehrlich's Ascites Carcinoma Cell-Treated Mice
Auteurs : Sriparna Kundusen [Inde] ; Malaya Gupta [Inde] ; Upal K. Mazumder [Inde] ; Pallab K. Haldar [Inde] ; Prerona Saha [Inde] ; Asis Bala [Inde]Source :
- ISRN Pharmacology [ 2090-5165 ] ; 2011.
Abstract
Url:
DOI: 10.5402/2011/138737
PubMed: 22084708
PubMed Central: 3195351
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antitumor Activity of <italic>Citrus maxima</italic> (Burm.) Merr. Leaves in Ehrlich's Ascites Carcinoma Cell-Treated Mice</title><author><name sortKey="Kundusen, Sriparna" sort="Kundusen, Sriparna" uniqKey="Kundusen S" first="Sriparna" last="Kundusen">Sriparna Kundusen</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032</wicri:regionArea><wicri:noRegion>West Bengal 700032</wicri:noRegion></affiliation></author><author><name sortKey="Gupta, Malaya" sort="Gupta, Malaya" uniqKey="Gupta M" first="Malaya" last="Gupta">Malaya Gupta</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032</wicri:regionArea><wicri:noRegion>West Bengal 700032</wicri:noRegion></affiliation></author><author><name sortKey="Mazumder, Upal K" sort="Mazumder, Upal K" uniqKey="Mazumder U" first="Upal K." last="Mazumder">Upal K. Mazumder</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032</wicri:regionArea><wicri:noRegion>West Bengal 700032</wicri:noRegion></affiliation></author><author><name sortKey="Haldar, Pallab K" sort="Haldar, Pallab K" uniqKey="Haldar P" first="Pallab K." last="Haldar">Pallab K. Haldar</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032</wicri:regionArea><wicri:noRegion>West Bengal 700032</wicri:noRegion></affiliation></author><author><name sortKey="Saha, Prerona" sort="Saha, Prerona" uniqKey="Saha P" first="Prerona" last="Saha">Prerona Saha</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032</wicri:regionArea><wicri:noRegion>West Bengal 700032</wicri:noRegion></affiliation></author><author><name sortKey="Bala, Asis" sort="Bala, Asis" uniqKey="Bala A" first="Asis" last="Bala">Asis Bala</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032</wicri:regionArea><wicri:noRegion>West Bengal 700032</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22084708</idno><idno type="pmc">3195351</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195351</idno><idno type="RBID">PMC:3195351</idno><idno type="doi">10.5402/2011/138737</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000F65</idno><idno type="wicri:Area/Pmc/Curation">000F64</idno><idno type="wicri:Area/Pmc/Checkpoint">000E88</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antitumor Activity of <italic>Citrus maxima</italic> (Burm.) Merr. Leaves in Ehrlich's Ascites Carcinoma Cell-Treated Mice</title><author><name sortKey="Kundusen, Sriparna" sort="Kundusen, Sriparna" uniqKey="Kundusen S" first="Sriparna" last="Kundusen">Sriparna Kundusen</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032</wicri:regionArea><wicri:noRegion>West Bengal 700032</wicri:noRegion></affiliation></author><author><name sortKey="Gupta, Malaya" sort="Gupta, Malaya" uniqKey="Gupta M" first="Malaya" last="Gupta">Malaya Gupta</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032</wicri:regionArea><wicri:noRegion>West Bengal 700032</wicri:noRegion></affiliation></author><author><name sortKey="Mazumder, Upal K" sort="Mazumder, Upal K" uniqKey="Mazumder U" first="Upal K." last="Mazumder">Upal K. Mazumder</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032</wicri:regionArea><wicri:noRegion>West Bengal 700032</wicri:noRegion></affiliation></author><author><name sortKey="Haldar, Pallab K" sort="Haldar, Pallab K" uniqKey="Haldar P" first="Pallab K." last="Haldar">Pallab K. Haldar</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032</wicri:regionArea><wicri:noRegion>West Bengal 700032</wicri:noRegion></affiliation></author><author><name sortKey="Saha, Prerona" sort="Saha, Prerona" uniqKey="Saha P" first="Prerona" last="Saha">Prerona Saha</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032</wicri:regionArea><wicri:noRegion>West Bengal 700032</wicri:noRegion></affiliation></author><author><name sortKey="Bala, Asis" sort="Bala, Asis" uniqKey="Bala A" first="Asis" last="Bala">Asis Bala</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032</wicri:regionArea><wicri:noRegion>West Bengal 700032</wicri:noRegion></affiliation></author></analytic><series><title level="j">ISRN Pharmacology</title><idno type="ISSN">2090-5165</idno><idno type="eISSN">2090-5173</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Context</italic>. The plant <italic>Citrus maxima</italic> Merr. (Rutaceae), commonly known as shaddock or pomelo is indigenous to tropical parts of Asia. The objective of present study is to evaluate the methanol extract of <italic>Citrus maxima</italic> leaves for its antitumor activity against Ehrlich's Ascites Carcinoma cell in Swiss albino mice.
<italic>Experimental design</italic>. The antitumor activity of methanol extract of <italic>Citrus maxima</italic> leaves (MECM) was evaluated against Ehrlich Ascites Carcinoma (EAC) cell line in Swiss albino mice. 2 × 10<sup>6</sup> cells were inoculated in different groups of animals. MECM (200 and 400 mg/kg BW i.p.) was administered for nine consecutive days. On day 10th half the animals of different groups were sacrificed for determination of tumor and haematological parameters and the rest half were kept with sufficient food and water ad libitum for determination of increase in life span.
<italic>Result and Discussions</italic>. Oral administration of the extract at the doses of 200 and 400 mg/kg significantly decreased tumor parameters such as tumor volume, viable tumor cell count and increased body weight, hematological parameters and life span in respect of the EAC control mice.
<italic>Conclusion</italic>. Experimental design exhibits significant antitumor activity of the extract (MECM) in a dose dependant manner.
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<front><journal-meta><journal-id journal-id-type="nlm-ta">ISRN Pharmacol</journal-id><journal-id journal-id-type="publisher-id">PHARMACOLOGY</journal-id><journal-title-group><journal-title>ISRN Pharmacology</journal-title></journal-title-group><issn pub-type="ppub">2090-5165</issn><issn pub-type="epub">2090-5173</issn><publisher><publisher-name>International Scholarly Research Network</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22084708</article-id><article-id pub-id-type="pmc">3195351</article-id><article-id pub-id-type="doi">10.5402/2011/138737</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Antitumor Activity of <italic>Citrus maxima</italic> (Burm.) Merr. Leaves in Ehrlich's Ascites Carcinoma Cell-Treated Mice</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>KunduSen</surname><given-names>Sriparna</given-names></name><xref ref-type="aff" rid="I1"></xref></contrib><contrib contrib-type="author"><name><surname>Gupta</surname><given-names>Malaya</given-names></name><xref ref-type="aff" rid="I1"></xref></contrib><contrib contrib-type="author"><name><surname>Mazumder</surname><given-names>Upal K.</given-names></name><xref ref-type="aff" rid="I1"></xref></contrib><contrib contrib-type="author"><name><surname>Haldar</surname><given-names>Pallab K.</given-names></name><xref ref-type="aff" rid="I1"></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Saha</surname><given-names>Prerona</given-names></name><xref ref-type="aff" rid="I1"></xref></contrib><contrib contrib-type="author"><name><surname>Bala</surname><given-names>Asis</given-names></name><xref ref-type="aff" rid="I1"></xref></contrib></contrib-group><aff id="I1">Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India</aff><author-notes><corresp id="cor1">*Pallab K. Haldar: <email>pallab_haldar@rediffmail.com</email></corresp><fn fn-type="other"><p>Academic Editor: P. Cos</p></fn></author-notes><pub-date pub-type="ppub"><year>2011</year></pub-date><pub-date pub-type="epub"><day>19</day><month>4</month><year>2011</year></pub-date><volume>2011</volume><elocation-id>138737</elocation-id><history><date date-type="received"><day>22</day><month>1</month><year>2011</year></date><date date-type="accepted"><day>13</day><month>3</month><year>2011</year></date></history><permissions><copyright-statement>Copyright © 2011 Sriparna KunduSen et al.</copyright-statement><copyright-year>2011</copyright-year><license license-type="open-access"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p><italic>Context</italic>. The plant <italic>Citrus maxima</italic> Merr. (Rutaceae), commonly known as shaddock or pomelo is indigenous to tropical parts of Asia. The objective of present study is to evaluate the methanol extract of <italic>Citrus maxima</italic> leaves for its antitumor activity against Ehrlich's Ascites Carcinoma cell in Swiss albino mice.
<italic>Experimental design</italic>. The antitumor activity of methanol extract of <italic>Citrus maxima</italic> leaves (MECM) was evaluated against Ehrlich Ascites Carcinoma (EAC) cell line in Swiss albino mice. 2 × 10<sup>6</sup> cells were inoculated in different groups of animals. MECM (200 and 400 mg/kg BW i.p.) was administered for nine consecutive days. On day 10th half the animals of different groups were sacrificed for determination of tumor and haematological parameters and the rest half were kept with sufficient food and water ad libitum for determination of increase in life span.
<italic>Result and Discussions</italic>. Oral administration of the extract at the doses of 200 and 400 mg/kg significantly decreased tumor parameters such as tumor volume, viable tumor cell count and increased body weight, hematological parameters and life span in respect of the EAC control mice.
<italic>Conclusion</italic>. Experimental design exhibits significant antitumor activity of the extract (MECM) in a dose dependant manner.
</p></abstract></article-meta></front><floats-group><fig id="fig1" position="float"><label>Figure 1</label><caption><p>Effect of MECM on haematological parameters of EAC cell-bearing mice (<italic>n</italic> = 6). Experimental groups are compared with EAC control group (<italic>P</italic> < .001)</p></caption><graphic xlink:href="PHARMACOLOGY2011-138737.001"></graphic></fig><fig id="fig2" position="float"><label>Figure 2</label><caption><p>Effect of MECM on different biochemical parameters in EAC-treated mice (<italic>n</italic> = 6). Experimental groups are compared with EAC control group (<italic>P</italic> < .001).</p></caption><graphic xlink:href="PHARMACOLOGY2011-138737.002"></graphic></fig><table-wrap id="tab1" position="float"><label>Table 1</label><caption><p>Effect of MECM on survival time, increased life span, tumor volume, viable cell count, and nonviable cell count of EAC tumor bearing mice (<italic>n</italic> = 6).</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Parameters</th><th align="center" rowspan="1" colspan="1">EAC control</th><th align="center" rowspan="1" colspan="1">200 mg/kg MECL</th><th align="center" rowspan="1" colspan="1">400 mg/kg MECL</th><th align="center" rowspan="1" colspan="1">20 mg/kg 5-FU</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Tumor volume (mL)</td><td align="center" rowspan="1" colspan="1">3.8 ± 0.26</td><td align="center" rowspan="1" colspan="1">2.15 ± 0.44*</td><td align="center" rowspan="1" colspan="1">1.56 ± 0.22*</td><td align="center" rowspan="1" colspan="1">0.73 ± 0.18*</td></tr><tr><td align="left" rowspan="1" colspan="1">MST (days)</td><td align="center" rowspan="1" colspan="1">19.5</td><td align="center" rowspan="1" colspan="1">28</td><td align="center" rowspan="1" colspan="1">34</td><td align="center" rowspan="1" colspan="1">40.5</td></tr><tr><td align="left" rowspan="1" colspan="1">%ILS</td><td align="center" rowspan="1" colspan="1">0</td><td align="center" rowspan="1" colspan="1">43.59</td><td align="center" rowspan="1" colspan="1">74.36</td><td align="center" rowspan="1" colspan="1">107.69</td></tr><tr><td align="left" rowspan="1" colspan="1">Viable cell ×10<sup>7</sup></td><td align="center" rowspan="1" colspan="1">7.47 ± 0.14</td><td align="center" rowspan="1" colspan="1">1.71 ± 0.06*</td><td align="center" rowspan="1" colspan="1">1.39 ± 0.15*</td><td align="center" rowspan="1" colspan="1">0.93 ± 0.04*</td></tr><tr><td align="left" rowspan="1" colspan="1">Nonviable cell ×10<sup>7</sup></td><td align="center" rowspan="1" colspan="1">0.32 ± 0.03</td><td align="center" rowspan="1" colspan="1">1.6 ± 0.04**</td><td align="center" rowspan="1" colspan="1">2.34 ± 0.05**</td><td align="center" rowspan="1" colspan="1">2.72 ± 0.05**</td></tr><tr><td align="left" rowspan="1" colspan="1">Total cell ×10<sup>7</sup></td><td align="center" rowspan="1" colspan="1">7.79</td><td align="center" rowspan="1" colspan="1">3.31</td><td align="center" rowspan="1" colspan="1">3.73</td><td align="center" rowspan="1" colspan="1">3.65</td></tr><tr><td align="left" rowspan="1" colspan="1">Viable%</td><td align="center" rowspan="1" colspan="1">95.89</td><td align="center" rowspan="1" colspan="1">51.66</td><td align="center" rowspan="1" colspan="1">37.27</td><td align="center" rowspan="1" colspan="1">25.48</td></tr><tr><td align="left" rowspan="1" colspan="1">Nonviable%</td><td align="center" rowspan="1" colspan="1">4.11</td><td align="center" rowspan="1" colspan="1">48.34</td><td align="center" rowspan="1" colspan="1">62.73</td><td align="center" rowspan="1" colspan="1">74.52</td></tr></tbody></table><table-wrap-foot><fn><p>*Experimental groups are compared with control group (<italic>P</italic> < .001).</p></fn><fn><p>**Experimental groups are compared with control group (<italic>P</italic> < .05).</p></fn></table-wrap-foot></table-wrap></floats-group></pmc><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Kundusen, Sriparna" sort="Kundusen, Sriparna" uniqKey="Kundusen S" first="Sriparna" last="Kundusen">Sriparna Kundusen</name></noRegion><name sortKey="Bala, Asis" sort="Bala, Asis" uniqKey="Bala A" first="Asis" last="Bala">Asis Bala</name><name sortKey="Gupta, Malaya" sort="Gupta, Malaya" uniqKey="Gupta M" first="Malaya" last="Gupta">Malaya Gupta</name><name sortKey="Haldar, Pallab K" sort="Haldar, Pallab K" uniqKey="Haldar P" first="Pallab K." last="Haldar">Pallab K. Haldar</name><name sortKey="Mazumder, Upal K" sort="Mazumder, Upal K" uniqKey="Mazumder U" first="Upal K." last="Mazumder">Upal K. Mazumder</name><name sortKey="Saha, Prerona" sort="Saha, Prerona" uniqKey="Saha P" first="Prerona" last="Saha">Prerona Saha</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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