Antioxidant and Anti-Inflammatory Activities of Extracts from Cassia alata, Eleusine indica, Eremomastax speciosa, Carica papaya and Polyscias fulva Medicinal Plants Collected in Cameroon
Identifieur interne : 000905 ( Pmc/Checkpoint ); précédent : 000904; suivant : 000906Antioxidant and Anti-Inflammatory Activities of Extracts from Cassia alata, Eleusine indica, Eremomastax speciosa, Carica papaya and Polyscias fulva Medicinal Plants Collected in Cameroon
Auteurs : Bertrand Sagnia [Cameroun] ; Donatella Fedeli [Italie] ; Rita Casetti [Italie] ; Carla Montesano [Italie] ; Giancarlo Falcioni [Italie] ; Vittorio Colizzi [Italie]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
The vast majority of the population around the world has always used medicinal plants as first source of health care to fight infectious and non infectious diseases. Most of these medicinal plants may have scientific evidence to be considered in general practice.
The aim of this work was to investigate the antioxidant capacities and anti-inflammatory activities of ethanol extracts of leaves of
Chemiluminescence was used to analyze the antioxidant activities of plant extracts against hydrogen peroxide or superoxide anion. Comet assays were used to analyze the protection against antioxidant-induced DNA damage induced in white blood cells after treating with hydrogen peroxide. Flow cytometry was used to measure γδ T cells proliferation and anti-inflammatory activity of γδ T cells and of immature dendritic cells (imDC) in the presence of different concentrations of plant extracts.
Ethanol extracts showed strong antioxidant properties against both hydrogen peroxide and superoxide anion.
These results clearly show the antioxidant capacity and anti-inflammatory activities of plant extracts collected in Cameroon. These properties of leaves and stem bark extracts may contribute to the value for these plants in traditional medicine and in general medical practice.
Url:
DOI: 10.1371/journal.pone.0103999
PubMed: 25090613
PubMed Central: 4121200
Affiliations:
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and <italic>Polyscias fulva</italic>
Medicinal Plants Collected in Cameroon</title>
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<author><name sortKey="Colizzi, Vittorio" sort="Colizzi, Vittorio" uniqKey="Colizzi V" first="Vittorio" last="Colizzi">Vittorio Colizzi</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antioxidant and Anti-Inflammatory Activities of Extracts from <italic>Cassia alata, Eleusine indica, Eremomastax speciosa, Carica papaya</italic>
and <italic>Polyscias fulva</italic>
Medicinal Plants Collected in Cameroon</title>
<author><name sortKey="Sagnia, Bertrand" sort="Sagnia, Bertrand" uniqKey="Sagnia B" first="Bertrand" last="Sagnia">Bertrand Sagnia</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Laboratory of Microbiology and Immunology, Chantal BIYA International Reference Centre for Research on Prevention and Management of HIV/AIDS (CIRCB), Yaounde, Cameroon</addr-line>
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<country xml:lang="fr">Cameroun</country>
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<wicri:noRegion>Yaounde</wicri:noRegion>
</affiliation>
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<author><name sortKey="Fedeli, Donatella" sort="Fedeli, Donatella" uniqKey="Fedeli D" first="Donatella" last="Fedeli">Donatella Fedeli</name>
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<wicri:regionArea>School of Pharmacy, University of Camerino, Camerino (MC)</wicri:regionArea>
<wicri:noRegion>Camerino (MC)</wicri:noRegion>
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<author><name sortKey="Montesano, Carla" sort="Montesano, Carla" uniqKey="Montesano C" first="Carla" last="Montesano">Carla Montesano</name>
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<author><name sortKey="Falcioni, Giancarlo" sort="Falcioni, Giancarlo" uniqKey="Falcioni G" first="Giancarlo" last="Falcioni">Giancarlo Falcioni</name>
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<author><name sortKey="Colizzi, Vittorio" sort="Colizzi, Vittorio" uniqKey="Colizzi V" first="Vittorio" last="Colizzi">Vittorio Colizzi</name>
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<region nuts="2">Latium</region>
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<affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Department of Biology, University of Rome Tor Vergata, Rome, Italy</addr-line>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biology, University of Rome Tor Vergata, Rome</wicri:regionArea>
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<series><title level="j">PLoS ONE</title>
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<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>The vast majority of the population around the world has always used medicinal plants as first source of health care to fight infectious and non infectious diseases. Most of these medicinal plants may have scientific evidence to be considered in general practice.</p>
</sec>
<sec><title>Objective</title>
<p>The aim of this work was to investigate the antioxidant capacities and anti-inflammatory activities of ethanol extracts of leaves of <italic>Cassia alata, Eleusine indica, Carica papaya, Eremomastax speciosa</italic>
and the stem bark of <italic>Polyscias fulva</italic>
, collected in Cameroon.</p>
</sec>
<sec><title>Methods</title>
<p>Chemiluminescence was used to analyze the antioxidant activities of plant extracts against hydrogen peroxide or superoxide anion. Comet assays were used to analyze the protection against antioxidant-induced DNA damage induced in white blood cells after treating with hydrogen peroxide. Flow cytometry was used to measure γδ T cells proliferation and anti-inflammatory activity of γδ T cells and of immature dendritic cells (imDC) in the presence of different concentrations of plant extracts.</p>
</sec>
<sec><title>Results</title>
<p>Ethanol extracts showed strong antioxidant properties against both hydrogen peroxide and superoxide anion. <italic>Cassia alata</italic>
showed the highest antioxidant activity. The effect of plant extracts on γδ T cells and imDC was evidenced by the dose dependent reduction in TNF-α production in the presence of <italic>Cassia alata</italic>
, <italic>Carica papaya, Eremomastax speciosa Eleusine indica,</italic>
and <italic>Polyscias fulva</italic>
. γδ T cells proliferation was affected to the greatest extent by <italic>Polyscias fulva</italic>
.</p>
</sec>
<sec><title>Conclusion</title>
<p>These results clearly show the antioxidant capacity and anti-inflammatory activities of plant extracts collected in Cameroon. These properties of leaves and stem bark extracts may contribute to the value for these plants in traditional medicine and in general medical practice.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, Ss" uniqKey="Huang S">SS Huang</name>
</author>
<author><name sortKey="Chiu, Cs" uniqKey="Chiu C">CS Chiu</name>
</author>
<author><name sortKey="Lin, Th" uniqKey="Lin T">TH Lin</name>
</author>
<author><name sortKey="Lee, Mm" uniqKey="Lee M">MM Lee</name>
</author>
<author><name sortKey="Lee, Cy" uniqKey="Lee C">CY Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morris, D" uniqKey="Morris D">D Morris</name>
</author>
<author><name sortKey="Khurasany, M" uniqKey="Khurasany M">M Khurasany</name>
</author>
<author><name sortKey="Nguyen, T" uniqKey="Nguyen T">T Nguyen</name>
</author>
<author><name sortKey="Kim, J" uniqKey="Kim J">J Kim</name>
</author>
<author><name sortKey="Guilford, F" uniqKey="Guilford F">F Guilford</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mandas, A" uniqKey="Mandas A">A Mandas</name>
</author>
<author><name sortKey="Iorio, El" uniqKey="Iorio E">EL Iorio</name>
</author>
<author><name sortKey="Congiu, Mg" uniqKey="Congiu M">MG Congiu</name>
</author>
<author><name sortKey="Balestrieri, C" uniqKey="Balestrieri C">C Balestrieri</name>
</author>
<author><name sortKey="Mereu, A" uniqKey="Mereu A">A Mereu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kumar, H" uniqKey="Kumar H">H Kumar</name>
</author>
<author><name sortKey="Koppula, S" uniqKey="Koppula S">S Koppula</name>
</author>
<author><name sortKey="Kim, Is" uniqKey="Kim I">IS Kim</name>
</author>
<author><name sortKey="More, Sv" uniqKey="More S">SV More</name>
</author>
<author><name sortKey="Kim, Bw" uniqKey="Kim B">BW Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Valko, M" uniqKey="Valko M">M Valko</name>
</author>
<author><name sortKey="Leibfritz, D" uniqKey="Leibfritz D">D Leibfritz</name>
</author>
<author><name sortKey="Moncol, J" uniqKey="Moncol J">J Moncol</name>
</author>
<author><name sortKey="Cronin, Mt" uniqKey="Cronin M">MT Cronin</name>
</author>
<author><name sortKey="Mazur, M" uniqKey="Mazur M">M Mazur</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Finkel, T" uniqKey="Finkel T">T Finkel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Floyd, Ra" uniqKey="Floyd R">RA Floyd</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Valko, M" uniqKey="Valko M">M Valko</name>
</author>
<author><name sortKey="Rhodes, Cj" uniqKey="Rhodes C">CJ Rhodes</name>
</author>
<author><name sortKey="Moncol, J" uniqKey="Moncol J">J Moncol</name>
</author>
<author><name sortKey="Izakovic, M" uniqKey="Izakovic M">M Izakovic</name>
</author>
<author><name sortKey="Mazur, M" uniqKey="Mazur M">M Mazur</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, L" uniqKey="Huang L">L Huang</name>
</author>
<author><name sortKey="Guan, T" uniqKey="Guan T">T Guan</name>
</author>
<author><name sortKey="Qian, Y" uniqKey="Qian Y">Y Qian</name>
</author>
<author><name sortKey="Huang, M" uniqKey="Huang M">M Huang</name>
</author>
<author><name sortKey="Tang, X" uniqKey="Tang X">X Tang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rao, Cv" uniqKey="Rao C">CV Rao</name>
</author>
<author><name sortKey="Verma, Ar" uniqKey="Verma A">AR Verma</name>
</author>
<author><name sortKey="Gupta, Pk" uniqKey="Gupta P">PK Gupta</name>
</author>
<author><name sortKey="Vijayakumar, M" uniqKey="Vijayakumar M">M Vijayakumar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mellman, I" uniqKey="Mellman I">I Mellman</name>
</author>
<author><name sortKey="Steinman, Rm" uniqKey="Steinman R">RM Steinman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nussbaumer, O" uniqKey="Nussbaumer O">O Nussbaumer</name>
</author>
<author><name sortKey="Gruenbacher, G" uniqKey="Gruenbacher G">G Gruenbacher</name>
</author>
<author><name sortKey="Gander, H" uniqKey="Gander H">H Gander</name>
</author>
<author><name sortKey="Thurnher, M" uniqKey="Thurnher M">M Thurnher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cunningham, Al" uniqKey="Cunningham A">AL Cunningham</name>
</author>
<author><name sortKey="Harman, A" uniqKey="Harman A">A Harman</name>
</author>
<author><name sortKey="Kim, M" uniqKey="Kim M">M Kim</name>
</author>
<author><name sortKey="Nasr, N" uniqKey="Nasr N">N Nasr</name>
</author>
<author><name sortKey="Lai, J" uniqKey="Lai J">J Lai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dunne, Mr" uniqKey="Dunne M">MR Dunne</name>
</author>
<author><name sortKey="Mangan, Ba" uniqKey="Mangan B">BA Mangan</name>
</author>
<author><name sortKey="Madrigal Estebas, L" uniqKey="Madrigal Estebas L">L Madrigal-Estebas</name>
</author>
<author><name sortKey="Doherty, Dg" uniqKey="Doherty D">DG Doherty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Afolabi, Is" uniqKey="Afolabi I">IS Afolabi</name>
</author>
<author><name sortKey="Osikoya, Io" uniqKey="Osikoya I">IO Osikoya</name>
</author>
<author><name sortKey="Fajimi, Od" uniqKey="Fajimi O">OD Fajimi</name>
</author>
<author><name sortKey="Usoro, Pi" uniqKey="Usoro P">PI Usoro</name>
</author>
<author><name sortKey="Ogunleye, Do" uniqKey="Ogunleye D">DO Ogunleye</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kisangau, Dp" uniqKey="Kisangau D">DP Kisangau</name>
</author>
<author><name sortKey="Hosea, Km" uniqKey="Hosea K">KM Hosea</name>
</author>
<author><name sortKey="Joseph, Cc" uniqKey="Joseph C">CC Joseph</name>
</author>
<author><name sortKey="Lyaruu, Hv" uniqKey="Lyaruu H">HV Lyaruu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ghoti, H" uniqKey="Ghoti H">H Ghoti</name>
</author>
<author><name sortKey="Fibach, E" uniqKey="Fibach E">E Fibach</name>
</author>
<author><name sortKey="Dana, M" uniqKey="Dana M">M Dana</name>
</author>
<author><name sortKey="Abu Shaban, M" uniqKey="Abu Shaban M">M Abu Shaban</name>
</author>
<author><name sortKey="Jeadi, H" uniqKey="Jeadi H">H Jeadi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aruoma, Oi" uniqKey="Aruoma O">OI Aruoma</name>
</author>
<author><name sortKey="Hayashi, Y" uniqKey="Hayashi Y">Y Hayashi</name>
</author>
<author><name sortKey="Marotta, F" uniqKey="Marotta F">F Marotta</name>
</author>
<author><name sortKey="Mantello, P" uniqKey="Mantello P">P Mantello</name>
</author>
<author><name sortKey="Rachmilewitz, E" uniqKey="Rachmilewitz E">E Rachmilewitz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Iweala, Ee" uniqKey="Iweala E">EE Iweala</name>
</author>
<author><name sortKey="Uhegbu, Fo" uniqKey="Uhegbu F">FO Uhegbu</name>
</author>
<author><name sortKey="Ogu, Gn" uniqKey="Ogu G">GN Ogu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sripanidkulchai, B" uniqKey="Sripanidkulchai B">B Sripanidkulchai</name>
</author>
<author><name sortKey="Wongpanich, V" uniqKey="Wongpanich V">V Wongpanich</name>
</author>
<author><name sortKey="Laupattarakasem, P" uniqKey="Laupattarakasem P">P Laupattarakasem</name>
</author>
<author><name sortKey="Suwansaksri, J" uniqKey="Suwansaksri J">J Suwansaksri</name>
</author>
<author><name sortKey="Jirakulsomchok, D" uniqKey="Jirakulsomchok D">D Jirakulsomchok</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tan, Pv" uniqKey="Tan P">PV Tan</name>
</author>
<author><name sortKey="Nditafon, Ng" uniqKey="Nditafon N">NG Nditafon</name>
</author>
<author><name sortKey="Yewah, Mp" uniqKey="Yewah M">MP Yewah</name>
</author>
<author><name sortKey="Dimo, T" uniqKey="Dimo T">T Dimo</name>
</author>
<author><name sortKey="Ayafor, Fj" uniqKey="Ayafor F">FJ Ayafor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Momo, Ce" uniqKey="Momo C">CE Momo</name>
</author>
<author><name sortKey="Oben, Je" uniqKey="Oben J">JE Oben</name>
</author>
<author><name sortKey="Tazoo, D" uniqKey="Tazoo D">D Tazoo</name>
</author>
<author><name sortKey="Dongo, E" uniqKey="Dongo E">E Dongo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Varghese, Gk" uniqKey="Varghese G">GK Varghese</name>
</author>
<author><name sortKey="Bose, Lv" uniqKey="Bose L">LV Bose</name>
</author>
<author><name sortKey="Habtemariam, S" uniqKey="Habtemariam S">S Habtemariam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ouedraogo, M" uniqKey="Ouedraogo M">M Ouedraogo</name>
</author>
<author><name sortKey="Da, Fl" uniqKey="Da F">FL Da</name>
</author>
<author><name sortKey="Fabre, A" uniqKey="Fabre A">A Fabre</name>
</author>
<author><name sortKey="Konate, K" uniqKey="Konate K">K Konate</name>
</author>
<author><name sortKey="Dibala, Ci" uniqKey="Dibala C">CI Dibala</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khan, M" uniqKey="Khan M">M Khan</name>
</author>
<author><name sortKey="Reddy, Cn" uniqKey="Reddy C">CN Reddy</name>
</author>
<author><name sortKey="Ravindra, G" uniqKey="Ravindra G">G Ravindra</name>
</author>
<author><name sortKey="Reddy, Kv" uniqKey="Reddy K">KV Reddy</name>
</author>
<author><name sortKey="Dubey, Pk" uniqKey="Dubey P">PK Dubey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ettebong, Eo" uniqKey="Ettebong E">EO Ettebong</name>
</author>
<author><name sortKey="Nwafor, Pa" uniqKey="Nwafor P">PA Nwafor</name>
</author>
<author><name sortKey="Okokon, Je" uniqKey="Okokon J">JE Okokon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Melo, Go" uniqKey="De Melo G">GO De Melo</name>
</author>
<author><name sortKey="Muzitano, Mf" uniqKey="Muzitano M">MF Muzitano</name>
</author>
<author><name sortKey="Legora Machado, A" uniqKey="Legora Machado A">A Legora-Machado</name>
</author>
<author><name sortKey="Almeida, Ta" uniqKey="Almeida T">TA Almeida</name>
</author>
<author><name sortKey="De Oliveira, Db" uniqKey="De Oliveira D">DB De Oliveira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Iqbal, M" uniqKey="Iqbal M">M Iqbal</name>
</author>
<author><name sortKey="Gnanaraj, C" uniqKey="Gnanaraj C">C Gnanaraj</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Njateng, Gs" uniqKey="Njateng G">GS Njateng</name>
</author>
<author><name sortKey="Gatsing, D" uniqKey="Gatsing D">D Gatsing</name>
</author>
<author><name sortKey="Mouokeu, Rs" uniqKey="Mouokeu R">RS Mouokeu</name>
</author>
<author><name sortKey="Lunga, Pk" uniqKey="Lunga P">PK Lunga</name>
</author>
<author><name sortKey="Kuiate, Jr" uniqKey="Kuiate J">JR Kuiate</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bedir, E" uniqKey="Bedir E">E Bedir</name>
</author>
<author><name sortKey="Toyang, Nj" uniqKey="Toyang N">NJ Toyang</name>
</author>
<author><name sortKey="Khan, Ia" uniqKey="Khan I">IA Khan</name>
</author>
<author><name sortKey="Walker, La" uniqKey="Walker L">LA Walker</name>
</author>
<author><name sortKey="Clark, Am" uniqKey="Clark A">AM Clark</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gabbianelli, R" uniqKey="Gabbianelli R">R Gabbianelli</name>
</author>
<author><name sortKey="Falcioni, G" uniqKey="Falcioni G">G Falcioni</name>
</author>
<author><name sortKey="Lupidi, G" uniqKey="Lupidi G">G Lupidi</name>
</author>
<author><name sortKey="Greci, L" uniqKey="Greci L">L Greci</name>
</author>
<author><name sortKey="Damiani, E" uniqKey="Damiani E">E Damiani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gabbianelli, R" uniqKey="Gabbianelli R">R Gabbianelli</name>
</author>
<author><name sortKey="Lupidi, G" uniqKey="Lupidi G">G Lupidi</name>
</author>
<author><name sortKey="Villarini, M" uniqKey="Villarini M">M Villarini</name>
</author>
<author><name sortKey="Falcioni, G" uniqKey="Falcioni G">G Falcioni</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ohkawa, H" uniqKey="Ohkawa H">H Ohkawa</name>
</author>
<author><name sortKey="Ohishi, N" uniqKey="Ohishi N">N Ohishi</name>
</author>
<author><name sortKey="Yagi, K" uniqKey="Yagi K">K Yagi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kirkpatrick, Dt" uniqKey="Kirkpatrick D">DT Kirkpatrick</name>
</author>
<author><name sortKey="Guth, Dj" uniqKey="Guth D">DJ Guth</name>
</author>
<author><name sortKey="Mavis, Rd" uniqKey="Mavis R">RD Mavis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rice Evans, Ca" uniqKey="Rice Evans C">CA Rice-Evans</name>
</author>
<author><name sortKey="Miller, Nj" uniqKey="Miller N">NJ Miller</name>
</author>
<author><name sortKey="Bolwell, Pg" uniqKey="Bolwell P">PG Bolwell</name>
</author>
<author><name sortKey="Bramley, Pm" uniqKey="Bramley P">PM Bramley</name>
</author>
<author><name sortKey="Pridham, Jb" uniqKey="Pridham J">JB Pridham</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mitchelmore, Cl" uniqKey="Mitchelmore C">CL Mitchelmore</name>
</author>
<author><name sortKey="Chipman, Jk" uniqKey="Chipman J">JK Chipman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mitchelmore, Cl" uniqKey="Mitchelmore C">CL Mitchelmore</name>
</author>
<author><name sortKey="Birmelin, C" uniqKey="Birmelin C">C Birmelin</name>
</author>
<author><name sortKey="Livingstone, Dr" uniqKey="Livingstone D">DR Livingstone</name>
</author>
<author><name sortKey="Chipman, Jk" uniqKey="Chipman J">JK Chipman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Birdi, T" uniqKey="Birdi T">T Birdi</name>
</author>
<author><name sortKey="Daswani, P" uniqKey="Daswani P">P Daswani</name>
</author>
<author><name sortKey="Brijesh, S" uniqKey="Brijesh S">S Brijesh</name>
</author>
<author><name sortKey="Tetali, P" uniqKey="Tetali P">P Tetali</name>
</author>
<author><name sortKey="Natu, A" uniqKey="Natu A">A Natu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thomas, E" uniqKey="Thomas E">E Thomas</name>
</author>
<author><name sortKey="Vandebroek, I" uniqKey="Vandebroek I">I Vandebroek</name>
</author>
<author><name sortKey="Sanca, S" uniqKey="Sanca S">S Sanca</name>
</author>
<author><name sortKey="Van Damme, P" uniqKey="Van Damme P">P Van Damme</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sen, Ta" uniqKey="Sen T">TA Sen</name>
</author>
<author><name sortKey="Kundak, Aa" uniqKey="Kundak A">AA Kundak</name>
</author>
<author><name sortKey="Guraksin, O" uniqKey="Guraksin O">O Guraksin</name>
</author>
<author><name sortKey="Demir, T" uniqKey="Demir T">T Demir</name>
</author>
<author><name sortKey="Narci, A" uniqKey="Narci A">A Narci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Focho, Da" uniqKey="Focho D">DA Focho</name>
</author>
<author><name sortKey="Newu, Mc" uniqKey="Newu M">MC Newu</name>
</author>
<author><name sortKey="Anjah, Mg" uniqKey="Anjah M">MG Anjah</name>
</author>
<author><name sortKey="Nwana, Fa" uniqKey="Nwana F">FA Nwana</name>
</author>
<author><name sortKey="Ambo, Fb" uniqKey="Ambo F">FB Ambo</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Cesari, I" uniqKey="Cesari I">I Cesari</name>
</author>
<author><name sortKey="Hoerle, M" uniqKey="Hoerle M">M Hoerle</name>
</author>
<author><name sortKey="Simoes Pires, C" uniqKey="Simoes Pires C">C Simoes-Pires</name>
</author>
<author><name sortKey="Grisoli, P" uniqKey="Grisoli P">P Grisoli</name>
</author>
<author><name sortKey="Queiroz, Ef" uniqKey="Queiroz E">EF Queiroz</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
</listBibl>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group><journal-title>PLoS ONE</journal-title>
</journal-title-group>
<issn pub-type="epub">1932-6203</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25090613</article-id>
<article-id pub-id-type="pmc">4121200</article-id>
<article-id pub-id-type="publisher-id">PONE-D-14-02484</article-id>
<article-id pub-id-type="doi">10.1371/journal.pone.0103999</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
<subj-group subj-group-type="Discipline-v2"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Biochemistry</subject>
</subj-group>
<subj-group><subject>Biotechnology</subject>
</subj-group>
<subj-group><subject>Cell Biology</subject>
<subj-group><subject>Molecular Cell Biology</subject>
</subj-group>
</subj-group>
<subj-group><subject>Immunology</subject>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v2"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Pharmacology</subject>
<subj-group><subject>Drug Research and Development</subject>
<subj-group><subject>Drug Discovery</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Antioxidant and Anti-Inflammatory Activities of Extracts from <italic>Cassia alata, Eleusine indica, Eremomastax speciosa, Carica papaya</italic>
and <italic>Polyscias fulva</italic>
Medicinal Plants Collected in Cameroon</article-title>
<alt-title alt-title-type="running-head">Antioxidant and Anti-Inflammatory of Plants Collected in Cameroon</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Sagnia</surname>
<given-names>Bertrand</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>*</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fedeli</surname>
<given-names>Donatella</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Casetti</surname>
<given-names>Rita</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Montesano</surname>
<given-names>Carla</given-names>
</name>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Falcioni</surname>
<given-names>Giancarlo</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Colizzi</surname>
<given-names>Vittorio</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
<addr-line>Laboratory of Microbiology and Immunology, Chantal BIYA International Reference Centre for Research on Prevention and Management of HIV/AIDS (CIRCB), Yaounde, Cameroon</addr-line>
</aff>
<aff id="aff2"><label>2</label>
<addr-line>School of Pharmacy, University of Camerino, Camerino (MC), Italy</addr-line>
</aff>
<aff id="aff3"><label>3</label>
<addr-line>Laboratory of Cellular Immunology, National Institute for Infectious Diseases “Lazzaro Spallanzani”, Rome, Italy</addr-line>
</aff>
<aff id="aff4"><label>4</label>
<addr-line>Department of Biology, University of Rome Tor Vergata, Rome, Italy</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Cordero</surname>
<given-names>Mario D.</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>University of Sevilla, Spain</addr-line>
</aff>
<author-notes><corresp id="cor1">* E-mail: <email>bertrandsagnia@yahoo.fr</email>
</corresp>
<fn fn-type="conflict"><p><bold>Competing Interests: </bold>
The authors have declared that no competing interests exist.</p>
</fn>
<fn fn-type="con"><p>Conceived and designed the experiments: GF BS VC. Performed the experiments: BS RC CM. Analyzed the data: BS DF RC. Contributed reagents/materials/analysis tools: GF VC DF. Wrote the paper: BS RC GF.</p>
</fn>
</author-notes>
<pub-date pub-type="collection"><year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>4</day>
<month>8</month>
<year>2014</year>
</pub-date>
<volume>9</volume>
<issue>8</issue>
<elocation-id>e103999</elocation-id>
<history><date date-type="received"><day>27</day>
<month>1</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>8</day>
<month>7</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-year>2014</copyright-year>
<copyright-holder>Sagnia et al</copyright-holder>
<license><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>
, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
</license>
</permissions>
<abstract><sec><title>Background</title>
<p>The vast majority of the population around the world has always used medicinal plants as first source of health care to fight infectious and non infectious diseases. Most of these medicinal plants may have scientific evidence to be considered in general practice.</p>
</sec>
<sec><title>Objective</title>
<p>The aim of this work was to investigate the antioxidant capacities and anti-inflammatory activities of ethanol extracts of leaves of <italic>Cassia alata, Eleusine indica, Carica papaya, Eremomastax speciosa</italic>
and the stem bark of <italic>Polyscias fulva</italic>
, collected in Cameroon.</p>
</sec>
<sec><title>Methods</title>
<p>Chemiluminescence was used to analyze the antioxidant activities of plant extracts against hydrogen peroxide or superoxide anion. Comet assays were used to analyze the protection against antioxidant-induced DNA damage induced in white blood cells after treating with hydrogen peroxide. Flow cytometry was used to measure γδ T cells proliferation and anti-inflammatory activity of γδ T cells and of immature dendritic cells (imDC) in the presence of different concentrations of plant extracts.</p>
</sec>
<sec><title>Results</title>
<p>Ethanol extracts showed strong antioxidant properties against both hydrogen peroxide and superoxide anion. <italic>Cassia alata</italic>
showed the highest antioxidant activity. The effect of plant extracts on γδ T cells and imDC was evidenced by the dose dependent reduction in TNF-α production in the presence of <italic>Cassia alata</italic>
, <italic>Carica papaya, Eremomastax speciosa Eleusine indica,</italic>
and <italic>Polyscias fulva</italic>
. γδ T cells proliferation was affected to the greatest extent by <italic>Polyscias fulva</italic>
.</p>
</sec>
<sec><title>Conclusion</title>
<p>These results clearly show the antioxidant capacity and anti-inflammatory activities of plant extracts collected in Cameroon. These properties of leaves and stem bark extracts may contribute to the value for these plants in traditional medicine and in general medical practice.</p>
</sec>
</abstract>
<funding-group><funding-statement>This work was supported by the School of Advanced Studies, University of Camerino, Italy, and the University of Rome Tor Vergata, Italy. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement>
</funding-group>
<counts><page-count count="10"></page-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Cameroun</li>
<li>Italie</li>
</country>
<region><li>Latium</li>
</region>
<settlement><li>Rome</li>
</settlement>
</list>
<tree><country name="Cameroun"><noRegion><name sortKey="Sagnia, Bertrand" sort="Sagnia, Bertrand" uniqKey="Sagnia B" first="Bertrand" last="Sagnia">Bertrand Sagnia</name>
</noRegion>
</country>
<country name="Italie"><noRegion><name sortKey="Fedeli, Donatella" sort="Fedeli, Donatella" uniqKey="Fedeli D" first="Donatella" last="Fedeli">Donatella Fedeli</name>
</noRegion>
<name sortKey="Casetti, Rita" sort="Casetti, Rita" uniqKey="Casetti R" first="Rita" last="Casetti">Rita Casetti</name>
<name sortKey="Colizzi, Vittorio" sort="Colizzi, Vittorio" uniqKey="Colizzi V" first="Vittorio" last="Colizzi">Vittorio Colizzi</name>
<name sortKey="Colizzi, Vittorio" sort="Colizzi, Vittorio" uniqKey="Colizzi V" first="Vittorio" last="Colizzi">Vittorio Colizzi</name>
<name sortKey="Falcioni, Giancarlo" sort="Falcioni, Giancarlo" uniqKey="Falcioni G" first="Giancarlo" last="Falcioni">Giancarlo Falcioni</name>
<name sortKey="Montesano, Carla" sort="Montesano, Carla" uniqKey="Montesano C" first="Carla" last="Montesano">Carla Montesano</name>
</country>
</tree>
</affiliations>
</record>
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