The Heat Shock Factor A4A Confers Salt Tolerance and Is Regulated by Oxidative Stress and the Mitogen-Activated Protein Kinases MPK3 and MPK61[C][W][OPEN]
Identifieur interne : 000681 ( Pmc/Checkpoint ); précédent : 000680; suivant : 000682The Heat Shock Factor A4A Confers Salt Tolerance and Is Regulated by Oxidative Stress and the Mitogen-Activated Protein Kinases MPK3 and MPK61[C][W][OPEN]
Auteurs : Imma Pérez-Salam ; Csaba Papdi ; Gábor Rig ; Laura Zsigmond ; Belmiro Vilela ; Victoria Lumbreras ; István Nagy ; Balázs Horváth ; M Nika Domoki ; Zsuzsa Darula ; Katalin Medzihradszky ; Lászl Bögre ; Csaba Koncz ; Lászl SzabadosSource :
- Plant Physiology [ 0032-0889 ] ; 2014.
Abstract
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DOI: 10.1104/pp.114.237891
PubMed: 24676858
PubMed Central: 4012591
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Heat Shock Factor A4A Confers Salt Tolerance and Is Regulated by Oxidative Stress and the Mitogen-Activated Protein Kinases MPK3 and MPK6<xref ref-type="fn" rid="fn1"><sup>1</sup></xref><xref ref-type="fn" rid="fn2"><sup>[C]</sup></xref><xref ref-type="fn" rid="fn3"><sup>[W]</sup></xref><xref ref-type="fn" rid="fn4"><sup>[OPEN]</sup></xref></title><author><name sortKey="Perez Salam, Imma" sort="Perez Salam, Imma" uniqKey="Perez Salam I" first="Imma" last="Pérez-Salam">Imma Pérez-Salam</name></author><author><name sortKey="Papdi, Csaba" sort="Papdi, Csaba" uniqKey="Papdi C" first="Csaba" last="Papdi">Csaba Papdi</name></author><author><name sortKey="Rig, Gabor" sort="Rig, Gabor" uniqKey="Rig G" first="Gábor" last="Rig">Gábor Rig</name></author><author><name sortKey="Zsigmond, Laura" sort="Zsigmond, Laura" uniqKey="Zsigmond L" first="Laura" last="Zsigmond">Laura Zsigmond</name></author><author><name sortKey="Vilela, Belmiro" sort="Vilela, Belmiro" uniqKey="Vilela B" first="Belmiro" last="Vilela">Belmiro Vilela</name></author><author><name sortKey="Lumbreras, Victoria" sort="Lumbreras, Victoria" uniqKey="Lumbreras V" first="Victoria" last="Lumbreras">Victoria Lumbreras</name></author><author><name sortKey="Nagy, Istvan" sort="Nagy, Istvan" uniqKey="Nagy I" first="István" last="Nagy">István Nagy</name></author><author><name sortKey="Horvath, Balazs" sort="Horvath, Balazs" uniqKey="Horvath B" first="Balázs" last="Horváth">Balázs Horváth</name></author><author><name sortKey="Domoki, M Nika" sort="Domoki, M Nika" uniqKey="Domoki M" first="M Nika" last="Domoki">M Nika Domoki</name></author><author><name sortKey="Darula, Zsuzsa" sort="Darula, Zsuzsa" uniqKey="Darula Z" first="Zsuzsa" last="Darula">Zsuzsa Darula</name></author><author><name sortKey="Medzihradszky, Katalin" sort="Medzihradszky, Katalin" uniqKey="Medzihradszky K" first="Katalin" last="Medzihradszky">Katalin Medzihradszky</name></author><author><name sortKey="Bogre, Laszl" sort="Bogre, Laszl" uniqKey="Bogre L" first="Lászl" last="Bögre">Lászl Bögre</name></author><author><name sortKey="Koncz, Csaba" sort="Koncz, Csaba" uniqKey="Koncz C" first="Csaba" last="Koncz">Csaba Koncz</name></author><author><name sortKey="Szabados, Laszl" sort="Szabados, Laszl" uniqKey="Szabados L" first="Lászl" last="Szabados">Lászl Szabados</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24676858</idno><idno type="pmc">4012591</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012591</idno><idno type="RBID">PMC:4012591</idno><idno type="doi">10.1104/pp.114.237891</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000D16</idno><idno type="wicri:Area/Pmc/Curation">000D15</idno><idno type="wicri:Area/Pmc/Checkpoint">000681</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Heat Shock Factor A4A Confers Salt Tolerance and Is Regulated by Oxidative Stress and the Mitogen-Activated Protein Kinases MPK3 and MPK6<xref ref-type="fn" rid="fn1"><sup>1</sup></xref><xref ref-type="fn" rid="fn2"><sup>[C]</sup></xref><xref ref-type="fn" rid="fn3"><sup>[W]</sup></xref><xref ref-type="fn" rid="fn4"><sup>[OPEN]</sup></xref></title><author><name sortKey="Perez Salam, Imma" sort="Perez Salam, Imma" uniqKey="Perez Salam I" first="Imma" last="Pérez-Salam">Imma Pérez-Salam</name></author><author><name sortKey="Papdi, Csaba" sort="Papdi, Csaba" uniqKey="Papdi C" first="Csaba" last="Papdi">Csaba Papdi</name></author><author><name sortKey="Rig, Gabor" sort="Rig, Gabor" uniqKey="Rig G" first="Gábor" last="Rig">Gábor Rig</name></author><author><name sortKey="Zsigmond, Laura" sort="Zsigmond, Laura" uniqKey="Zsigmond L" first="Laura" last="Zsigmond">Laura Zsigmond</name></author><author><name sortKey="Vilela, Belmiro" sort="Vilela, Belmiro" uniqKey="Vilela B" first="Belmiro" last="Vilela">Belmiro Vilela</name></author><author><name sortKey="Lumbreras, Victoria" sort="Lumbreras, Victoria" uniqKey="Lumbreras V" first="Victoria" last="Lumbreras">Victoria Lumbreras</name></author><author><name sortKey="Nagy, Istvan" sort="Nagy, Istvan" uniqKey="Nagy I" first="István" last="Nagy">István Nagy</name></author><author><name sortKey="Horvath, Balazs" sort="Horvath, Balazs" uniqKey="Horvath B" first="Balázs" last="Horváth">Balázs Horváth</name></author><author><name sortKey="Domoki, M Nika" sort="Domoki, M Nika" uniqKey="Domoki M" first="M Nika" last="Domoki">M Nika Domoki</name></author><author><name sortKey="Darula, Zsuzsa" sort="Darula, Zsuzsa" uniqKey="Darula Z" first="Zsuzsa" last="Darula">Zsuzsa Darula</name></author><author><name sortKey="Medzihradszky, Katalin" sort="Medzihradszky, Katalin" uniqKey="Medzihradszky K" first="Katalin" last="Medzihradszky">Katalin Medzihradszky</name></author><author><name sortKey="Bogre, Laszl" sort="Bogre, Laszl" uniqKey="Bogre L" first="Lászl" last="Bögre">Lászl Bögre</name></author><author><name sortKey="Koncz, Csaba" sort="Koncz, Csaba" uniqKey="Koncz C" first="Csaba" last="Koncz">Csaba Koncz</name></author><author><name sortKey="Szabados, Laszl" sort="Szabados, Laszl" uniqKey="Szabados L" first="Lászl" last="Szabados">Lászl Szabados</name></author></analytic><series><title level="j">Plant Physiology</title><idno type="ISSN">0032-0889</idno><idno type="eISSN">1532-2548</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>An Arabidopsis Heat Shock Factor affects tolerance to salt as well as other abiotic stresses, forms homodimers dependent on the redox regulation, interacts with MAP kinases, and alters the expression of a large set of stress-induced genes</italic>.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Plant Physiol</journal-id><journal-id journal-id-type="iso-abbrev">Plant Physiol</journal-id><journal-id journal-id-type="hwp">plantphysiol</journal-id><journal-id journal-id-type="publisher-id">aspb</journal-id><journal-title-group><journal-title>Plant Physiology</journal-title></journal-title-group><issn pub-type="ppub">0032-0889</issn><issn pub-type="epub">1532-2548</issn><publisher><publisher-name>American Society of Plant Biologists</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24676858</article-id><article-id pub-id-type="pmc">4012591</article-id><article-id pub-id-type="publisher-id">237891</article-id><article-id pub-id-type="doi">10.1104/pp.114.237891</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject><subj-group subj-group-type="heading"><subject>Signaling and Response</subject></subj-group></subj-group></article-categories><title-group><article-title>The Heat Shock Factor A4A Confers Salt Tolerance and Is Regulated by Oxidative Stress and the Mitogen-Activated Protein Kinases MPK3 and MPK6<xref ref-type="fn" rid="fn1"><sup>1</sup></xref><xref ref-type="fn" rid="fn2"><sup>[C]</sup></xref><xref ref-type="fn" rid="fn3"><sup>[W]</sup></xref><xref ref-type="fn" rid="fn4"><sup>[OPEN]</sup></xref></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Pérez-Salamó</surname><given-names>Imma</given-names></name></contrib><contrib contrib-type="author"><name><surname>Papdi</surname><given-names>Csaba</given-names></name></contrib><contrib contrib-type="author"><name><surname>Rigó</surname><given-names>Gábor</given-names></name></contrib><contrib contrib-type="author"><name><surname>Zsigmond</surname><given-names>Laura</given-names></name></contrib><contrib contrib-type="author"><name><surname>Vilela</surname><given-names>Belmiro</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lumbreras</surname><given-names>Victoria</given-names></name></contrib><contrib contrib-type="author"><name><surname>Nagy</surname><given-names>István</given-names></name></contrib><contrib contrib-type="author"><name><surname>Horváth</surname><given-names>Balázs</given-names></name></contrib><contrib contrib-type="author"><name><surname>Domoki</surname><given-names>Mónika</given-names></name></contrib><contrib contrib-type="author"><name><surname>Darula</surname><given-names>Zsuzsa</given-names></name></contrib><contrib contrib-type="author"><name><surname>Medzihradszky</surname><given-names>Katalin</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bögre</surname><given-names>László</given-names></name></contrib><contrib contrib-type="author"><name><surname>Koncz</surname><given-names>Csaba</given-names></name></contrib><contrib contrib-type="author"><name><surname>Szabados</surname><given-names>László</given-names></name><xref ref-type="corresp" rid="cor1">*</xref></contrib><aff id="aff1">Biological Research Centre, H–6726 Szeged, Hungary (I.P.-S., C.P., G.R., L.Z., I.N., B.H., M.D., Z.D., K.M., C.K., L.S.);</aff><aff id="aff2">Royal Holloway, University of London, Egham Hill, Surrey TW20 0EX, United Kingdom (C.P., L.B.);</aff><aff id="aff3">University of Szeged, H–6726 Szeged, Hungary (L.Z.);</aff><aff id="aff4">Centre for Research in Agricultural Genomics, 08193 Barcelona, Spain (B.V., V.L.); and</aff><aff id="aff5">Max-Planck-Institut für Züchtungsforschung, 50829 Cologne, Germany (C.K.)</aff></contrib-group><author-notes><fn><p><ext-link ext-link-type="uri" xlink:href="http://www.plantphysiol.org/cgi/doi/10.1104/pp.114.237891">www.plantphysiol.org/cgi/doi/10.1104/pp.114.237891</ext-link></p></fn><corresp id="cor1"><label>*</label>Address correspondence to <email>szabados@brc.hu</email>.</corresp><fn id="afn1"><p>The author responsible for distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors (<ext-link ext-link-type="uri" xlink:href="http://www.plantphysiol.org">www.plantphysiol.org</ext-link>) is: László Szabados (<email>szabados@brc.hu</email>).</p></fn></author-notes><pmc-comment>Fake ppub date generated by PMC from publisher
pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><month>5</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>27</day><month>3</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>27</day><month>3</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>165</volume><issue>1</issue><fpage>319</fpage><lpage>334</lpage><history><date date-type="received"><day>15</day><month>2</month><year>2014</year></date><date date-type="accepted"><day>25</day><month>3</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 American Society of Plant Biologists. All Rights Reserved.</copyright-statement><copyright-year>2014</copyright-year></permissions><self-uri xlink:role="icon" xlink:type="simple" xlink:href="PP_237891_ic1.gif"></self-uri><self-uri content-type="alt-lang-pdf zh" xlink:type="simple" xlink:href="319.chinese.pdf"></self-uri><abstract abstract-type="precis"><p><italic>An Arabidopsis Heat Shock Factor affects tolerance to salt as well as other abiotic stresses, forms homodimers dependent on the redox regulation, interacts with MAP kinases, and alters the expression of a large set of stress-induced genes</italic>.</p></abstract><abstract><p>Heat shock factors (HSFs) are principal regulators of plant responses to several abiotic stresses. Here, we show that estradiol-dependent induction of HSFA4A confers enhanced tolerance to salt and oxidative agents, whereas inactivation of HSFA4A results in hypersensitivity to salt stress in Arabidopsis (<italic>Arabidopsis thaliana</italic>). Estradiol induction of HSFA4A in transgenic plants decreases, while the knockout <italic>hsfa4a</italic> mutation elevates hydrogen peroxide accumulation and lipid peroxidation. Overexpression of HSFA4A alters the transcription of a large set of genes regulated by oxidative stress. In yeast (<italic>Saccharomyces cerevisiae</italic>) two-hybrid and bimolecular fluorescence complementation assays, HSFA4A shows homomeric interaction, which is reduced by alanine replacement of three conserved cysteine residues. HSFA4A interacts with mitogen-activated protein kinases MPK3 and MPK6 in yeast and plant cells. MPK3 and MPK6 phosphorylate HSFA4A in vitro on three distinct sites, serine-309 being the major phosphorylation site. Activation of the MPK3 and MPK6 mitogen-activated protein kinase pathway led to the transcriptional activation of the <italic>HEAT SHOCK PROTEIN17.6A</italic> gene. In agreement that mutation of serine-309 to alanine strongly diminished phosphorylation of HSFA4A, it also strongly reduced the transcriptional activation of <italic>HEAT SHOCK PROTEIN17.6A</italic>. These data suggest that HSFA4A is a substrate of the MPK3/MPK6 signaling and that it regulates stress responses in Arabidopsis.</p></abstract><counts><page-count count="16"></page-count></counts></article-meta><notes><glossary><title>Glossary</title><def-list><def-item><term id="term1">BiFC</term><def id="def1"><p>bimolecular fluorescence complementation</p></def></def-item><def-item><term id="term2">HSE</term><def id="def2"><p>heat stress element</p></def></def-item><def-item><term id="term3">ROS</term><def id="def3"><p>reactive oxygen species</p></def></def-item><def-item><term id="term4">H<sub>2</sub>O<sub>2</sub></term><def id="def4"><p>hydrogen peroxide</p></def></def-item><def-item><term id="term5">MAP</term><def id="def5"><p>mitogen-activated protein</p></def></def-item><def-item><term id="term6">COS</term><def id="def6"><p>Conditional Overexpression System</p></def></def-item><def-item><term id="term7">cDNA</term><def id="def7"><p>complementary DNA</p></def></def-item><def-item><term id="term8">T-DNA</term><def id="def8"><p>transfer DNA</p></def></def-item><def-item><term id="term9">Col-0</term><def id="def9"><p>ecotype Columbia</p></def></def-item><def-item><term id="term10">MS</term><def id="def10"><p>Murashige and Skoog</p></def></def-item><def-item><term id="term11">RNA-Seq</term><def id="def11"><p>RNA sequencing</p></def></def-item><def-item><term id="term12">RT</term><def id="def12"><p>reverse transcription</p></def></def-item><def-item><term id="term13">CaMV</term><def id="def13"><p><italic>Cauliflower mosaic virus</italic></p></def></def-item><def-item><term id="term14">Y2H</term><def id="def14"><p>yeast two-hybrid</p></def></def-item><def-item><term id="term15"><italic>m/z</italic></term><def id="def15"><p>mass-to-charge ratio</p></def></def-item></def-list></glossary></notes></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Bogre, Laszl" sort="Bogre, Laszl" uniqKey="Bogre L" first="Lászl" last="Bögre">Lászl Bögre</name><name sortKey="Darula, Zsuzsa" sort="Darula, Zsuzsa" uniqKey="Darula Z" first="Zsuzsa" last="Darula">Zsuzsa Darula</name><name sortKey="Domoki, M Nika" sort="Domoki, M Nika" uniqKey="Domoki M" first="M Nika" last="Domoki">M Nika Domoki</name><name sortKey="Horvath, Balazs" sort="Horvath, Balazs" uniqKey="Horvath B" first="Balázs" last="Horváth">Balázs Horváth</name><name sortKey="Koncz, Csaba" sort="Koncz, Csaba" uniqKey="Koncz C" first="Csaba" last="Koncz">Csaba Koncz</name><name sortKey="Lumbreras, Victoria" sort="Lumbreras, Victoria" uniqKey="Lumbreras V" first="Victoria" last="Lumbreras">Victoria Lumbreras</name><name sortKey="Medzihradszky, Katalin" sort="Medzihradszky, Katalin" uniqKey="Medzihradszky K" first="Katalin" last="Medzihradszky">Katalin Medzihradszky</name><name sortKey="Nagy, Istvan" sort="Nagy, Istvan" uniqKey="Nagy I" first="István" last="Nagy">István Nagy</name><name sortKey="Papdi, Csaba" sort="Papdi, Csaba" uniqKey="Papdi C" first="Csaba" last="Papdi">Csaba Papdi</name><name sortKey="Perez Salam, Imma" sort="Perez Salam, Imma" uniqKey="Perez Salam I" first="Imma" last="Pérez-Salam">Imma Pérez-Salam</name><name sortKey="Rig, Gabor" sort="Rig, Gabor" uniqKey="Rig G" first="Gábor" last="Rig">Gábor Rig</name><name sortKey="Szabados, Laszl" sort="Szabados, Laszl" uniqKey="Szabados L" first="Lászl" last="Szabados">Lászl Szabados</name><name sortKey="Vilela, Belmiro" sort="Vilela, Belmiro" uniqKey="Vilela B" first="Belmiro" last="Vilela">Belmiro Vilela</name><name sortKey="Zsigmond, Laura" sort="Zsigmond, Laura" uniqKey="Zsigmond L" first="Laura" last="Zsigmond">Laura Zsigmond</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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