OrangerV1, PascalFrancis, Corpus, bibRecord, 000515

Efficient and scalable method in isolation of polymethoxyflavones from orange peel extract by supercritical fluid chromatography

Identifieur interne : 000515 ( PascalFrancis/Corpus ); précédent : 000514; suivant : 000516

Efficient and scalable method in isolation of polymethoxyflavones from orange peel extract by supercritical fluid chromatography

Auteurs : SHIMING LI ; Ted Lambros ; ZHENYU WANG ; Robert Goodnow ; Chi-Tang Ho

Source :

Journal of chromatography. B [ 1570-0232 ] ; 2007.

RBID : Pascal:07-0095133

Descripteurs français

Pascal (Inist)
- Isolement, Pelure, Extrait, Chromatographie SFC, Citrus sinensis, Caractérisation, Orange douce.

English descriptors

KwdEn :
- Characterization, Citrus sinensis, Extract, Isolation, Peel, Supercritical fluid chromatography, Sweet orange.

Abstract

Polymethoxyflavones (PMFs) from citrus genus are of particular interest because of their broad spectrum of biological activities, such as anti-inflammatory, anti-carcinogenic, and anti-atherogenic properties. Recently, the exploration into the beneficial health properties of PMFs in citrus fruits has dramatically increased. However, the supply of pure PMFs in the in vivo study is a limiting factor due to the difficulties in large-scale isolation of the interested PMFs. Therefore, the development of an efficient and a scalable separation method of PMFs is necessary and significant. In this paper, we report a newly developed method for efficient and relatively large-scale isolation of four PMFs from sweet orange (Citrus sinensis) peel by employing supercritical chromatography (SFC): nobiletin, tangeretin, 3,5,6,7,8,3',4'-heptamethoxyflavone and 5,6,7,4'-tetramethoxyflavone.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 1570-0232`
A03		`1`		`@0 J. chromatogr., B`
A05				`@2 846`
A06				`@2 1-2`
A08	`01`	`1`	`ENG`	`@1 Efficient and scalable method in isolation of polymethoxyflavones from orange peel extract by supercritical fluid chromatography`
A11	`01`	`1`		`@1 SHIMING LI`
A11	`02`	`1`		`@1 LAMBROS (Ted)`
A11	`03`	`1`		`@1 ZHENYU WANG`
A11	`04`	`1`		`@1 GOODNOW (Robert)`
A11	`05`	`1`		`@1 HO (Chi-Tang)`
A14	`01`			`@1 Department of Drug Discovery, Hoffmann-La Roche Inc @2 Nutley, NJ 07110 @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut.`
A14	`02`			`@1 Department of Food Science, Rutgers University, 65 Dudley Road @2 New Brunswick, NJ 08901-8520 @3 USA @Z 5 aut.`
A20				`@1 291-297`
A21				`@1 2007`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 8577B @5 354000159787200380`
A44				`@0 0000 @1 © 2007 INIST-CNRS. All rights reserved.`
A45				`@0 21 ref.`
A47	`01`	`1`		`@0 07-0095133`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Journal of chromatography. B`
A66	`01`			`@0 NLD`
C01	`01`		`ENG`	@0 Polymethoxyflavones (PMFs) from citrus genus are of particular interest because of their broad spectrum of biological activities, such as anti-inflammatory, anti-carcinogenic, and anti-atherogenic properties. Recently, the exploration into the beneficial health properties of PMFs in citrus fruits has dramatically increased. However, the supply of pure PMFs in the in vivo study is a limiting factor due to the difficulties in large-scale isolation of the interested PMFs. Therefore, the development of an efficient and a scalable separation method of PMFs is necessary and significant. In this paper, we report a newly developed method for efficient and relatively large-scale isolation of four PMFs from sweet orange (Citrus sinensis) peel by employing supercritical chromatography (SFC): nobiletin, tangeretin, 3,5,6,7,8,3',4'-heptamethoxyflavone and 5,6,7,4'-tetramethoxyflavone.
C02	`01`	`X`		`@0 002B02A02`
C02	`02`	`X`		`@0 002A02`
C03	`01`	`X`	`FRE`	`@0 Isolement @5 01`
C03	`01`	`X`	`ENG`	`@0 Isolation @5 01`
C03	`01`	`X`	`SPA`	`@0 Aislamiento @5 01`
C03	`02`	`X`	`FRE`	`@0 Pelure @5 02`
C03	`02`	`X`	`ENG`	`@0 Peel @5 02`
C03	`02`	`X`	`SPA`	`@0 Cáscara @5 02`
C03	`03`	`X`	`FRE`	`@0 Extrait @5 03`
C03	`03`	`X`	`ENG`	`@0 Extract @5 03`
C03	`03`	`X`	`SPA`	`@0 Extracto @5 03`
C03	`04`	`X`	`FRE`	`@0 Chromatographie SFC @5 04`
C03	`04`	`X`	`ENG`	`@0 Supercritical fluid chromatography @5 04`
C03	`04`	`X`	`SPA`	`@0 Cromatografia fluido supercritico @5 04`
C03	`05`	`X`	`FRE`	`@0 Citrus sinensis @2 NS @5 05`
C03	`05`	`X`	`ENG`	`@0 Citrus sinensis @2 NS @5 05`
C03	`05`	`X`	`SPA`	`@0 Citrus sinensis @2 NS @5 05`
C03	`06`	`X`	`FRE`	`@0 Caractérisation @5 06`
C03	`06`	`X`	`ENG`	`@0 Characterization @5 06`
C03	`06`	`X`	`SPA`	`@0 Caracterización @5 06`
C03	`07`	`X`	`FRE`	`@0 Orange douce @4 CD @5 96`
C03	`07`	`X`	`ENG`	`@0 Sweet orange @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Rutaceae @2 NS`
C07	`01`	`X`	`ENG`	`@0 Rutaceae @2 NS`
C07	`01`	`X`	`SPA`	`@0 Rutaceae @2 NS`
C07	`02`	`X`	`FRE`	`@0 Dicotyledones @2 NS`
C07	`02`	`X`	`ENG`	`@0 Dicotyledones @2 NS`
C07	`02`	`X`	`SPA`	`@0 Dicotyledones @2 NS`
C07	`03`	`X`	`FRE`	`@0 Angiospermae @2 NS`
C07	`03`	`X`	`ENG`	`@0 Angiospermae @2 NS`
C07	`03`	`X`	`SPA`	`@0 Angiospermae @2 NS`
C07	`04`	`X`	`FRE`	`@0 Spermatophyta @2 NS`
C07	`04`	`X`	`ENG`	`@0 Spermatophyta @2 NS`
C07	`04`	`X`	`SPA`	`@0 Spermatophyta @2 NS`
N21				`@1 064`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 07-0095133 INIST
ET :	Efficient and scalable method in isolation of polymethoxyflavones from orange peel extract by supercritical fluid chromatography
AU :	SHIMING LI; LAMBROS (Ted); ZHENYU WANG; GOODNOW (Robert); HO (Chi-Tang)
AF :	Department of Drug Discovery, Hoffmann-La Roche Inc/Nutley, NJ 07110/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut.); Department of Food Science, Rutgers University, 65 Dudley Road/New Brunswick, NJ 08901-8520/Etats-Unis (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Journal of chromatography. B; ISSN 1570-0232; Pays-Bas; Da. 2007; Vol. 846; No. 1-2; Pp. 291-297; Bibl. 21 ref.
LA :	Anglais
EA :	Polymethoxyflavones (PMFs) from citrus genus are of particular interest because of their broad spectrum of biological activities, such as anti-inflammatory, anti-carcinogenic, and anti-atherogenic properties. Recently, the exploration into the beneficial health properties of PMFs in citrus fruits has dramatically increased. However, the supply of pure PMFs in the in vivo study is a limiting factor due to the difficulties in large-scale isolation of the interested PMFs. Therefore, the development of an efficient and a scalable separation method of PMFs is necessary and significant. In this paper, we report a newly developed method for efficient and relatively large-scale isolation of four PMFs from sweet orange (Citrus sinensis) peel by employing supercritical chromatography (SFC): nobiletin, tangeretin, 3,5,6,7,8,3',4'-heptamethoxyflavone and 5,6,7,4'-tetramethoxyflavone.
CC :	002B02A02; 002A02
FD :	Isolement; Pelure; Extrait; Chromatographie SFC; Citrus sinensis; Caractérisation; Orange douce
FG :	Rutaceae; Dicotyledones; Angiospermae; Spermatophyta
ED :	Isolation; Peel; Extract; Supercritical fluid chromatography; Citrus sinensis; Characterization; Sweet orange
EG :	Rutaceae; Dicotyledones; Angiospermae; Spermatophyta
SD :	Aislamiento; Cáscara; Extracto; Cromatografia fluido supercritico; Citrus sinensis; Caracterización
LO :	INIST-8577B.354000159787200380
ID :	07-0095133

Links to Exploration step

Pascal:07-0095133

Le document en format XML

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<front><div type="abstract" xml:lang="en">Polymethoxyflavones (PMFs) from citrus genus are of particular interest because of their broad spectrum of biological activities, such as anti-inflammatory, anti-carcinogenic, and anti-atherogenic properties. Recently, the exploration into the beneficial health properties of PMFs in citrus fruits has dramatically increased. However, the supply of pure PMFs in the in vivo study is a limiting factor due to the difficulties in large-scale isolation of the interested PMFs. Therefore, the development of an efficient and a scalable separation method of PMFs is necessary and significant. In this paper, we report a newly developed method for efficient and relatively large-scale isolation of four PMFs from sweet orange (Citrus sinensis) peel by employing supercritical chromatography (SFC): nobiletin, tangeretin, 3,5,6,7,8,3',4'-heptamethoxyflavone and 5,6,7,4'-tetramethoxyflavone.</div>
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<fC01 i1="01" l="ENG"><s0>Polymethoxyflavones (PMFs) from citrus genus are of particular interest because of their broad spectrum of biological activities, such as anti-inflammatory, anti-carcinogenic, and anti-atherogenic properties. Recently, the exploration into the beneficial health properties of PMFs in citrus fruits has dramatically increased. However, the supply of pure PMFs in the in vivo study is a limiting factor due to the difficulties in large-scale isolation of the interested PMFs. Therefore, the development of an efficient and a scalable separation method of PMFs is necessary and significant. In this paper, we report a newly developed method for efficient and relatively large-scale isolation of four PMFs from sweet orange (Citrus sinensis) peel by employing supercritical chromatography (SFC): nobiletin, tangeretin, 3,5,6,7,8,3',4'-heptamethoxyflavone and 5,6,7,4'-tetramethoxyflavone.</s0>
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<fC07 i1="03" i2="X" l="SPA"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fN21><s1>064</s1>
</fN21>
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<fN82><s1>OTO</s1>
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<server><NO>PASCAL 07-0095133 INIST</NO>
<ET>Efficient and scalable method in isolation of polymethoxyflavones from orange peel extract by supercritical fluid chromatography</ET>
<AU>SHIMING LI; LAMBROS (Ted); ZHENYU WANG; GOODNOW (Robert); HO (Chi-Tang)</AU>
<AF>Department of Drug Discovery, Hoffmann-La Roche Inc/Nutley, NJ 07110/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut.); Department of Food Science, Rutgers University, 65 Dudley Road/New Brunswick, NJ 08901-8520/Etats-Unis (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of chromatography. B; ISSN 1570-0232; Pays-Bas; Da. 2007; Vol. 846; No. 1-2; Pp. 291-297; Bibl. 21 ref.</SO>
<LA>Anglais</LA>
<EA>Polymethoxyflavones (PMFs) from citrus genus are of particular interest because of their broad spectrum of biological activities, such as anti-inflammatory, anti-carcinogenic, and anti-atherogenic properties. Recently, the exploration into the beneficial health properties of PMFs in citrus fruits has dramatically increased. However, the supply of pure PMFs in the in vivo study is a limiting factor due to the difficulties in large-scale isolation of the interested PMFs. Therefore, the development of an efficient and a scalable separation method of PMFs is necessary and significant. In this paper, we report a newly developed method for efficient and relatively large-scale isolation of four PMFs from sweet orange (Citrus sinensis) peel by employing supercritical chromatography (SFC): nobiletin, tangeretin, 3,5,6,7,8,3',4'-heptamethoxyflavone and 5,6,7,4'-tetramethoxyflavone.</EA>
<CC>002B02A02; 002A02</CC>
<FD>Isolement; Pelure; Extrait; Chromatographie SFC; Citrus sinensis; Caractérisation; Orange douce</FD>
<FG>Rutaceae; Dicotyledones; Angiospermae; Spermatophyta</FG>
<ED>Isolation; Peel; Extract; Supercritical fluid chromatography; Citrus sinensis; Characterization; Sweet orange</ED>
<EG>Rutaceae; Dicotyledones; Angiospermae; Spermatophyta</EG>
<SD>Aislamiento; Cáscara; Extracto; Cromatografia fluido supercritico; Citrus sinensis; Caracterización</SD>
<LO>INIST-8577B.354000159787200380</LO>
<ID>07-0095133</ID>
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Efficient and scalable method in isolation of polymethoxyflavones from orange peel extract by supercritical fluid chromatography

Efficient and scalable method in isolation of polymethoxyflavones from orange peel extract by supercritical fluid chromatography

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