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Ceramides as Possible Nutraceutical Compounds: Characterization of the Ceramides of the Moro Blood Orange (Citrus sinensis)

Identifieur interne : 000078 ( PascalFrancis/Corpus ); précédent : 000077; suivant : 000079

Ceramides as Possible Nutraceutical Compounds: Characterization of the Ceramides of the Moro Blood Orange (Citrus sinensis)

Auteurs : Manuela Valsecchi ; Laura Mauri ; Riccardo Casellato ; Maria Grazia Ciampa ; Luisa Rizza ; Andrea Bonina ; Francesco Bonina ; Sandro Sonnino

Source :

RBID : Pascal:12-0417967

Descripteurs français

English descriptors

Abstract

Ceramides are presented as nutraceutical compounds for protection of colon carcinoma and as important cosmetic preparation components, increasing absorption through the skin. Therefore, the ceramide (Cer) content of Moro blood oranges was determined by mass spectrometry. A total of 114 Cer species were identified: ∼160 mg in the peels and ∼140 mg in the pulp per kilogram of oranges, expressed as "milligram equivalents of d18:1,17:0 Cer". The predominant ceramides contained 4-hydroxy-8-sphingenine (t18:1Δ8) and 4-hydroxysphinganine (t18:0) as long-chain bases (LCBs) and fatty acids (FAs) with different structures. In the pulp, t18:1Δ8- and t18:0-containing Cer species comprised 50.5 and 33.5% of the total, respectively, 11.5 and 3.5% non-hydroxylated FAs, respectively, 32.0 and 21.0% α-hydroxylated FAs, respectively, and 7.0 and 9.0% α,β-hydroxylated FAs, respectively. In the peels, t18:1Δ8- and t18:0-containing species comprised 49.5 and 34.5% of the total, respectively, 16.0 and 1.5% non-hydroxylated FAs, respectively, 31.5 and 29.0% α-hydroxylated FAs, respectively, and 2.0 and 4.0% α,β-hydroxylated FAs, respectively.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
A01 01  1    @0 0021-8561
A02 01      @0 JAFCAU
A03   1    @0 J. agric. food chem. : (Print)
A05       @2 60
A06       @2 40
A08 01  1  ENG  @1 Ceramides as Possible Nutraceutical Compounds: Characterization of the Ceramides of the Moro Blood Orange (Citrus sinensis)
A11 01  1    @1 VALSECCHI (Manuela)
A11 02  1    @1 MAURI (Laura)
A11 03  1    @1 CASELLATO (Riccardo)
A11 04  1    @1 GRAZIA CIAMPA (Maria)
A11 05  1    @1 RIZZA (Luisa)
A11 06  1    @1 BONINA (Andrea)
A11 07  1    @1 BONINA (Francesco)
A11 08  1    @1 SONNINO (Sandro)
A14 01      @1 Department of Medical Biotechnology and Translational Medicine, University of Milan, Via Fratelli Cervi 93 @2 20090 Segrate (Milan) @3 ITA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 8 aut.
A14 02      @1 Research and Development, Bionap Srl, Via Badalà 6 @2 95010 Santa Venerina (Catania) @3 ITA @Z 5 aut. @Z 6 aut.
A14 03      @1 Department of Drug Sciences, University of Catania, Viale Andrea Doria 6 @2 95125 Catania @3 ITA @Z 7 aut.
A20       @1 10103-10110
A21       @1 2012
A23 01      @0 ENG
A43 01      @1 INIST @2 7332 @5 354000505338930210
A44       @0 0000 @1 © 2012 INIST-CNRS. All rights reserved.
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A47 01  1    @0 12-0417967
A60       @1 P
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A64 01  1    @0 Journal of agricultural and food chemistry : (Print)
A66 01      @0 USA
C01 01    ENG  @0 Ceramides are presented as nutraceutical compounds for protection of colon carcinoma and as important cosmetic preparation components, increasing absorption through the skin. Therefore, the ceramide (Cer) content of Moro blood oranges was determined by mass spectrometry. A total of 114 Cer species were identified: ∼160 mg in the peels and ∼140 mg in the pulp per kilogram of oranges, expressed as "milligram equivalents of d18:1,17:0 Cer". The predominant ceramides contained 4-hydroxy-8-sphingenine (t18:1Δ8) and 4-hydroxysphinganine (t18:0) as long-chain bases (LCBs) and fatty acids (FAs) with different structures. In the pulp, t18:1Δ8- and t18:0-containing Cer species comprised 50.5 and 33.5% of the total, respectively, 11.5 and 3.5% non-hydroxylated FAs, respectively, 32.0 and 21.0% α-hydroxylated FAs, respectively, and 7.0 and 9.0% α,β-hydroxylated FAs, respectively. In the peels, t18:1Δ8- and t18:0-containing species comprised 49.5 and 34.5% of the total, respectively, 16.0 and 1.5% non-hydroxylated FAs, respectively, 31.5 and 29.0% α-hydroxylated FAs, respectively, and 2.0 and 4.0% α,β-hydroxylated FAs, respectively.
C02 01  X    @0 002A35B09
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C03 01  X  ENG  @0 Characterization @5 01
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C03 02  X  FRE  @0 Sang @5 02
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C03 02  X  SPA  @0 Sangre @5 02
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C03 03  X  ENG  @0 Orange @5 10
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C03 07  X  ENG  @0 Cosmetic @2 FX @5 20
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C07 02  X  SPA  @0 Rutaceae @2 NS
C07 03  X  FRE  @0 Dicotyledones @2 NS
C07 03  X  ENG  @0 Dicotyledones @2 NS
C07 03  X  SPA  @0 Dicotyledones @2 NS
C07 04  X  FRE  @0 Angiospermae @2 NS
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C07 04  X  SPA  @0 Angiospermae @2 NS
C07 05  X  FRE  @0 Spermatophyta @2 NS
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C07 06  X  ENG  @0 Citrus fruit @5 49
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N21       @1 324
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Format Inist (serveur)

NO : PASCAL 12-0417967 INIST
ET : Ceramides as Possible Nutraceutical Compounds: Characterization of the Ceramides of the Moro Blood Orange (Citrus sinensis)
AU : VALSECCHI (Manuela); MAURI (Laura); CASELLATO (Riccardo); GRAZIA CIAMPA (Maria); RIZZA (Luisa); BONINA (Andrea); BONINA (Francesco); SONNINO (Sandro)
AF : Department of Medical Biotechnology and Translational Medicine, University of Milan, Via Fratelli Cervi 93/20090 Segrate (Milan)/Italie (1 aut., 2 aut., 3 aut., 4 aut., 8 aut.); Research and Development, Bionap Srl, Via Badalà 6/95010 Santa Venerina (Catania)/Italie (5 aut., 6 aut.); Department of Drug Sciences, University of Catania, Viale Andrea Doria 6/95125 Catania/Italie (7 aut.)
DT : Publication en série; Niveau analytique
SO : Journal of agricultural and food chemistry : (Print); ISSN 0021-8561; Coden JAFCAU; Etats-Unis; Da. 2012; Vol. 60; No. 40; Pp. 10103-10110; Bibl. 40 ref.
LA : Anglais
EA : Ceramides are presented as nutraceutical compounds for protection of colon carcinoma and as important cosmetic preparation components, increasing absorption through the skin. Therefore, the ceramide (Cer) content of Moro blood oranges was determined by mass spectrometry. A total of 114 Cer species were identified: ∼160 mg in the peels and ∼140 mg in the pulp per kilogram of oranges, expressed as "milligram equivalents of d18:1,17:0 Cer". The predominant ceramides contained 4-hydroxy-8-sphingenine (t18:1Δ8) and 4-hydroxysphinganine (t18:0) as long-chain bases (LCBs) and fatty acids (FAs) with different structures. In the pulp, t18:1Δ8- and t18:0-containing Cer species comprised 50.5 and 33.5% of the total, respectively, 11.5 and 3.5% non-hydroxylated FAs, respectively, 32.0 and 21.0% α-hydroxylated FAs, respectively, and 7.0 and 9.0% α,β-hydroxylated FAs, respectively. In the peels, t18:1Δ8- and t18:0-containing species comprised 49.5 and 34.5% of the total, respectively, 16.0 and 1.5% non-hydroxylated FAs, respectively, 31.5 and 29.0% α-hydroxylated FAs, respectively, and 2.0 and 4.0% α,β-hydroxylated FAs, respectively.
CC : 002A35B09
FD : Caractérisation; Sang; Orange; Citrus sinensis; Pelure; Pulpe; Cosmétique; Peau
FG : Fruit; Rutaceae; Dicotyledones; Angiospermae; Spermatophyta; Agrume
ED : Characterization; Blood; Orange; Citrus sinensis; Peel; Pulp; Cosmetic; Skin
EG : Fruit; Rutaceae; Dicotyledones; Angiospermae; Spermatophyta; Citrus fruit
SD : Caracterización; Sangre; Naranja; Citrus sinensis; Cáscara; Pulpa; Cosmético; Piel
LO : INIST-7332.354000505338930210
ID : 12-0417967

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<div type="abstract" xml:lang="en">Ceramides are presented as nutraceutical compounds for protection of colon carcinoma and as important cosmetic preparation components, increasing absorption through the skin. Therefore, the ceramide (Cer) content of Moro blood oranges was determined by mass spectrometry. A total of 114 Cer species were identified: ∼160 mg in the peels and ∼140 mg in the pulp per kilogram of oranges, expressed as "milligram equivalents of d18:1,17:0 Cer". The predominant ceramides contained 4-hydroxy-8-sphingenine (t18:1
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<sup>Δ8</sup>
- and t18:0-containing species comprised 49.5 and 34.5% of the total, respectively, 16.0 and 1.5% non-hydroxylated FAs, respectively, 31.5 and 29.0% α-hydroxylated FAs, respectively, and 2.0 and 4.0% α,β-hydroxylated FAs, respectively.</div>
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</fA11>
<fA11 i1="05" i2="1">
<s1>RIZZA (Luisa)</s1>
</fA11>
<fA11 i1="06" i2="1">
<s1>BONINA (Andrea)</s1>
</fA11>
<fA11 i1="07" i2="1">
<s1>BONINA (Francesco)</s1>
</fA11>
<fA11 i1="08" i2="1">
<s1>SONNINO (Sandro)</s1>
</fA11>
<fA14 i1="01">
<s1>Department of Medical Biotechnology and Translational Medicine, University of Milan, Via Fratelli Cervi 93</s1>
<s2>20090 Segrate (Milan)</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="02">
<s1>Research and Development, Bionap Srl, Via Badalà 6</s1>
<s2>95010 Santa Venerina (Catania)</s2>
<s3>ITA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="03">
<s1>Department of Drug Sciences, University of Catania, Viale Andrea Doria 6</s1>
<s2>95125 Catania</s2>
<s3>ITA</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA20>
<s1>10103-10110</s1>
</fA20>
<fA21>
<s1>2012</s1>
</fA21>
<fA23 i1="01">
<s0>ENG</s0>
</fA23>
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<s1>INIST</s1>
<s2>7332</s2>
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<s1>© 2012 INIST-CNRS. All rights reserved.</s1>
</fA44>
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<s0>40 ref.</s0>
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<s0>12-0417967</s0>
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<s1>P</s1>
</fA60>
<fA61>
<s0>A</s0>
</fA61>
<fA64 i1="01" i2="1">
<s0>Journal of agricultural and food chemistry : (Print)</s0>
</fA64>
<fA66 i1="01">
<s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG">
<s0>Ceramides are presented as nutraceutical compounds for protection of colon carcinoma and as important cosmetic preparation components, increasing absorption through the skin. Therefore, the ceramide (Cer) content of Moro blood oranges was determined by mass spectrometry. A total of 114 Cer species were identified: ∼160 mg in the peels and ∼140 mg in the pulp per kilogram of oranges, expressed as "milligram equivalents of d18:1,17:0 Cer". The predominant ceramides contained 4-hydroxy-8-sphingenine (t18:1
<sup>Δ8</sup>
) and 4-hydroxysphinganine (t18:0) as long-chain bases (LCBs) and fatty acids (FAs) with different structures. In the pulp, t18:1
<sup>Δ8</sup>
- and t18:0-containing Cer species comprised 50.5 and 33.5% of the total, respectively, 11.5 and 3.5% non-hydroxylated FAs, respectively, 32.0 and 21.0% α-hydroxylated FAs, respectively, and 7.0 and 9.0% α,β-hydroxylated FAs, respectively. In the peels, t18:1
<sup>Δ8</sup>
- and t18:0-containing species comprised 49.5 and 34.5% of the total, respectively, 16.0 and 1.5% non-hydroxylated FAs, respectively, 31.5 and 29.0% α-hydroxylated FAs, respectively, and 2.0 and 4.0% α,β-hydroxylated FAs, respectively.</s0>
</fC01>
<fC02 i1="01" i2="X">
<s0>002A35B09</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE">
<s0>Caractérisation</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG">
<s0>Characterization</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA">
<s0>Caracterización</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE">
<s0>Sang</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG">
<s0>Blood</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA">
<s0>Sangre</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Orange</s0>
<s5>10</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Orange</s0>
<s5>10</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Naranja</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE">
<s0>Citrus sinensis</s0>
<s2>NS</s2>
<s5>11</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>Citrus sinensis</s0>
<s2>NS</s2>
<s5>11</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>Citrus sinensis</s0>
<s2>NS</s2>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE">
<s0>Pelure</s0>
<s5>12</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Peel</s0>
<s5>12</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Cáscara</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE">
<s0>Pulpe</s0>
<s5>19</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG">
<s0>Pulp</s0>
<s5>19</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA">
<s0>Pulpa</s0>
<s5>19</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE">
<s0>Cosmétique</s0>
<s2>FX</s2>
<s5>20</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG">
<s0>Cosmetic</s0>
<s2>FX</s2>
<s5>20</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA">
<s0>Cosmético</s0>
<s2>FX</s2>
<s5>20</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE">
<s0>Peau</s0>
<s5>21</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG">
<s0>Skin</s0>
<s5>21</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA">
<s0>Piel</s0>
<s5>21</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Fruit</s0>
<s5>08</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Fruit</s0>
<s5>08</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Fruto</s0>
<s5>08</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Rutaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Rutaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Rutaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE">
<s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG">
<s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA">
<s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE">
<s0>Agrume</s0>
<s5>49</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG">
<s0>Citrus fruit</s0>
<s5>49</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA">
<s0>Agrios</s0>
<s5>49</s5>
</fC07>
<fN21>
<s1>324</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
</fN82>
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<NO>PASCAL 12-0417967 INIST</NO>
<ET>Ceramides as Possible Nutraceutical Compounds: Characterization of the Ceramides of the Moro Blood Orange (Citrus sinensis)</ET>
<AU>VALSECCHI (Manuela); MAURI (Laura); CASELLATO (Riccardo); GRAZIA CIAMPA (Maria); RIZZA (Luisa); BONINA (Andrea); BONINA (Francesco); SONNINO (Sandro)</AU>
<AF>Department of Medical Biotechnology and Translational Medicine, University of Milan, Via Fratelli Cervi 93/20090 Segrate (Milan)/Italie (1 aut., 2 aut., 3 aut., 4 aut., 8 aut.); Research and Development, Bionap Srl, Via Badalà 6/95010 Santa Venerina (Catania)/Italie (5 aut., 6 aut.); Department of Drug Sciences, University of Catania, Viale Andrea Doria 6/95125 Catania/Italie (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of agricultural and food chemistry : (Print); ISSN 0021-8561; Coden JAFCAU; Etats-Unis; Da. 2012; Vol. 60; No. 40; Pp. 10103-10110; Bibl. 40 ref.</SO>
<LA>Anglais</LA>
<EA>Ceramides are presented as nutraceutical compounds for protection of colon carcinoma and as important cosmetic preparation components, increasing absorption through the skin. Therefore, the ceramide (Cer) content of Moro blood oranges was determined by mass spectrometry. A total of 114 Cer species were identified: ∼160 mg in the peels and ∼140 mg in the pulp per kilogram of oranges, expressed as "milligram equivalents of d18:1,17:0 Cer". The predominant ceramides contained 4-hydroxy-8-sphingenine (t18:1
<sup>Δ8</sup>
) and 4-hydroxysphinganine (t18:0) as long-chain bases (LCBs) and fatty acids (FAs) with different structures. In the pulp, t18:1
<sup>Δ8</sup>
- and t18:0-containing Cer species comprised 50.5 and 33.5% of the total, respectively, 11.5 and 3.5% non-hydroxylated FAs, respectively, 32.0 and 21.0% α-hydroxylated FAs, respectively, and 7.0 and 9.0% α,β-hydroxylated FAs, respectively. In the peels, t18:1
<sup>Δ8</sup>
- and t18:0-containing species comprised 49.5 and 34.5% of the total, respectively, 16.0 and 1.5% non-hydroxylated FAs, respectively, 31.5 and 29.0% α-hydroxylated FAs, respectively, and 2.0 and 4.0% α,β-hydroxylated FAs, respectively.</EA>
<CC>002A35B09</CC>
<FD>Caractérisation; Sang; Orange; Citrus sinensis; Pelure; Pulpe; Cosmétique; Peau</FD>
<FG>Fruit; Rutaceae; Dicotyledones; Angiospermae; Spermatophyta; Agrume</FG>
<ED>Characterization; Blood; Orange; Citrus sinensis; Peel; Pulp; Cosmetic; Skin</ED>
<EG>Fruit; Rutaceae; Dicotyledones; Angiospermae; Spermatophyta; Citrus fruit</EG>
<SD>Caracterización; Sangre; Naranja; Citrus sinensis; Cáscara; Pulpa; Cosmético; Piel</SD>
<LO>INIST-7332.354000505338930210</LO>
<ID>12-0417967</ID>
</server>
</inist>
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