OrangerV1, PascalFrancis, Corpus, bibRecord, 000058

A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry

Identifieur interne : 000058 ( PascalFrancis/Corpus ); précédent : 000057; suivant : 000059

A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry

Auteurs : Johanna Rudb Ck ; Nurul Islam ; Ulrika Nilsson ; Ann-Therese Karlberg

Source :

Journal of separation science : (Print) [ 1615-9306 ] ; 2013.

RBID : Pascal:13-0187994

Descripteurs français

Pascal (Inist)
- Allergène, Parfum, Monoterpène, Autooxydation, Dermatite de contact, Analyse chimique, Analyse qualitative, Electrospray, Hydroperoxyde organique, Produit réaction, p-Mentha-1,8-diène, Citrus aurantium, Bigarade, Huile essentielle, Chromatographie HPLC, Méthode couplée, Terpénoïde, Citrus sinensis, LC MS MS, Linalol, Linalol acétate, p-Menthane dérivé, Spectrométrie masse tandem, Orange douce.

English descriptors

KwdEn :
- 1,8-p-Menthadiene, Allergen, Autoxidation, Bitter orange, Chemical analysis, Citrus aurantium, Citrus sinensis, Contact dermatitis, Coupled method, Electrospray, Essential oil, HPLC chromatography, Monoterpene, Organic hydroperoxide, Perfume, Qualitative analysis, Reaction product, Sweet orange, Tandem mass spectrometry, Terpenoid.

Abstract

Different compositions of monoterpenes are utilized for their pleasant scent in cosmetics and perfumes. However, the most commonly used fragrance terpenes easily oxidize upon contact with air, forming strongly skin-sensitizing hydroperoxides. Due to their thermolability and low UV absorbance, detection methods for hydroperoxides are scarce. For the first time, a simple and sensitive method using LC/ESI-MS/MS was developed to quantitatively determine hydroperoxides from the common fragrance compounds linalool, linalyl acetate, and limonene. The method was applied to autoxidized petitgrain oil and sweet orange oil. A separation was accomplished using a C₃ column. The method LOD for the investigated hydroperoxides in the essential oils was below 0.3 μg/mL, corresponding to 0.3 ppm. For prevention purposes and according to EU regulations, concentrations in cosmetics exceeding 100 ppm in "rinse-off" and 10 ppm in "stay-on" products of linalool and limonene must be labeled. However, the products may still contain allergens, such as hydroperoxides, formed by oxidative degradation of their parent terpenes. The sensitivity and selectivity of the presented LC/MS/MS method enables detection of hydroperoxides from the fragrance terpenes linalool, linalyl acetate, and limonene. However, for routine measurements, the method requires further validation.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry`
A11	`01`	`1`		`@1 RUDBÄCK (Johanna)`
A11	`02`	`1`		`@1 ISLAM (Nurul)`
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A11	`04`	`1`		`@1 KARLBERG (Ann-Therese)`
A14	`01`			`@1 Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg @2 Gothenburg @3 SWE @Z 1 aut. @Z 2 aut. @Z 4 aut.`
A14	`02`			`@1 Department of Analytical Chemistry, Stockholm University @2 Stockholm @3 SWE @Z 3 aut.`
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C01	`01`		`ENG`	@0 Different compositions of monoterpenes are utilized for their pleasant scent in cosmetics and perfumes. However, the most commonly used fragrance terpenes easily oxidize upon contact with air, forming strongly skin-sensitizing hydroperoxides. Due to their thermolability and low UV absorbance, detection methods for hydroperoxides are scarce. For the first time, a simple and sensitive method using LC/ESI-MS/MS was developed to quantitatively determine hydroperoxides from the common fragrance compounds linalool, linalyl acetate, and limonene. The method was applied to autoxidized petitgrain oil and sweet orange oil. A separation was accomplished using a C₃ column. The method LOD for the investigated hydroperoxides in the essential oils was below 0.3 μg/mL, corresponding to 0.3 ppm. For prevention purposes and according to EU regulations, concentrations in cosmetics exceeding 100 ppm in "rinse-off" and 10 ppm in "stay-on" products of linalool and limonene must be labeled. However, the products may still contain allergens, such as hydroperoxides, formed by oxidative degradation of their parent terpenes. The sensitivity and selectivity of the presented LC/MS/MS method enables detection of hydroperoxides from the fragrance terpenes linalool, linalyl acetate, and limonene. However, for routine measurements, the method requires further validation.
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C03	`02`	`X`	`FRE`	`@0 Parfum @5 02`
C03	`02`	`X`	`ENG`	`@0 Perfume @5 02`
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C03	`03`	`X`	`SPA`	`@0 Monoterpeno @5 03`
C03	`04`	`X`	`FRE`	`@0 Autooxydation @5 04`
C03	`04`	`X`	`ENG`	`@0 Autoxidation @5 04`
C03	`04`	`X`	`SPA`	`@0 Autooxidación @5 04`
C03	`05`	`X`	`FRE`	`@0 Dermatite de contact @5 05`
C03	`05`	`X`	`ENG`	`@0 Contact dermatitis @5 05`
C03	`05`	`X`	`SPA`	`@0 Dermatitis de contacto @5 05`
C03	`06`	`X`	`FRE`	`@0 Analyse chimique @5 06`
C03	`06`	`X`	`ENG`	`@0 Chemical analysis @5 06`
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C03	`07`	`X`	`FRE`	`@0 Analyse qualitative @5 07`
C03	`07`	`X`	`ENG`	`@0 Qualitative analysis @5 07`
C03	`07`	`X`	`SPA`	`@0 Análisis cualitativo @5 07`
C03	`08`	`X`	`FRE`	`@0 Electrospray @5 08`
C03	`08`	`X`	`ENG`	`@0 Electrospray @5 08`
C03	`08`	`X`	`SPA`	`@0 Electrospray @5 08`
C03	`09`	`X`	`FRE`	`@0 Hydroperoxyde organique @5 09`
C03	`09`	`X`	`ENG`	`@0 Organic hydroperoxide @5 09`
C03	`09`	`X`	`SPA`	`@0 Hidroperóxido orgánico @5 09`
C03	`10`	`X`	`FRE`	`@0 Produit réaction @5 10`
C03	`10`	`X`	`ENG`	`@0 Reaction product @5 10`
C03	`10`	`X`	`SPA`	`@0 Producto reacción @5 10`
C03	`11`	`X`	`FRE`	`@0 p-Mentha-1,8-diène @2 NK @5 11`
C03	`11`	`X`	`ENG`	`@0 1,8-p-Menthadiene @2 NK @5 11`
C03	`11`	`X`	`SPA`	`@0 1,8-p-Mentadieno @2 NK @5 11`
C03	`12`	`X`	`FRE`	`@0 Citrus aurantium @2 NS @5 12`
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C03	`12`	`X`	`SPA`	`@0 Citrus aurantium @2 NS @5 12`
C03	`13`	`X`	`FRE`	`@0 Bigarade @5 13`
C03	`13`	`X`	`ENG`	`@0 Bitter orange @5 13`
C03	`13`	`X`	`SPA`	`@0 Naranja amarga @5 13`
C03	`14`	`X`	`FRE`	`@0 Huile essentielle @5 14`
C03	`14`	`X`	`ENG`	`@0 Essential oil @5 14`
C03	`14`	`X`	`SPA`	`@0 Aceite esencial @5 14`
C03	`15`	`X`	`FRE`	`@0 Chromatographie HPLC @5 32`
C03	`15`	`X`	`ENG`	`@0 HPLC chromatography @5 32`
C03	`15`	`X`	`SPA`	`@0 Cromatografía HPLC @5 32`
C03	`16`	`X`	`FRE`	`@0 Méthode couplée @5 33`
C03	`16`	`X`	`ENG`	`@0 Coupled method @5 33`
C03	`16`	`X`	`SPA`	`@0 Método acoplado @5 33`
C03	`17`	`X`	`FRE`	`@0 Terpénoïde @2 FX @5 35`
C03	`17`	`X`	`ENG`	`@0 Terpenoid @2 FX @5 35`
C03	`17`	`X`	`SPA`	`@0 Terpenoide @2 FX @5 35`
C03	`18`	`X`	`FRE`	`@0 Citrus sinensis @2 NS @5 41`
C03	`18`	`X`	`ENG`	`@0 Citrus sinensis @2 NS @5 41`
C03	`18`	`X`	`SPA`	`@0 Citrus sinensis @2 NS @5 41`
C03	`19`	`X`	`FRE`	`@0 LC MS MS @4 INC @5 76`
C03	`20`	`X`	`FRE`	`@0 Linalol @2 NK @4 INC @5 77`
C03	`21`	`X`	`FRE`	`@0 Linalol acétate @2 NK @4 INC @5 78`
C03	`22`	`X`	`FRE`	`@0 p-Menthane dérivé @2 NK @4 INC @5 91`
C03	`23`	`X`	`FRE`	`@0 Spectrométrie masse tandem @4 CD @5 96`
C03	`23`	`X`	`ENG`	`@0 Tandem mass spectrometry @4 CD @5 96`
C03	`23`	`X`	`SPA`	`@0 Espectrometría masa en tándem @4 CD @5 96`
C03	`24`	`X`	`FRE`	`@0 Orange douce @4 CD @5 97`
C03	`24`	`X`	`ENG`	`@0 Sweet orange @4 CD @5 97`
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C07	`04`	`X`	`FRE`	`@0 Spermatophyta @2 NS`
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C07	`04`	`X`	`SPA`	`@0 Spermatophyta @2 NS`
N21				`@1 168`

Format Inist (serveur)

NO :	PASCAL 13-0187994 INIST
ET :	A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry
AU :	RUDBÄCK (Johanna); ISLAM (Nurul); NILSSON (Ulrika); KARLBERG (Ann-Therese)
AF :	Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg/Gothenburg/Suède (1 aut., 2 aut., 4 aut.); Department of Analytical Chemistry, Stockholm University/Stockholm/Suède (3 aut.)
DT :	Publication en série; Niveau analytique
SO :	Journal of separation science : (Print); ISSN 1615-9306; Allemagne; Da. 2013; Vol. 36; No. 8; Pp. 1370-1378; Bibl. 28 ref.
LA :	Anglais
EA :	Different compositions of monoterpenes are utilized for their pleasant scent in cosmetics and perfumes. However, the most commonly used fragrance terpenes easily oxidize upon contact with air, forming strongly skin-sensitizing hydroperoxides. Due to their thermolability and low UV absorbance, detection methods for hydroperoxides are scarce. For the first time, a simple and sensitive method using LC/ESI-MS/MS was developed to quantitatively determine hydroperoxides from the common fragrance compounds linalool, linalyl acetate, and limonene. The method was applied to autoxidized petitgrain oil and sweet orange oil. A separation was accomplished using a C₃ column. The method LOD for the investigated hydroperoxides in the essential oils was below 0.3 μg/mL, corresponding to 0.3 ppm. For prevention purposes and according to EU regulations, concentrations in cosmetics exceeding 100 ppm in "rinse-off" and 10 ppm in "stay-on" products of linalool and limonene must be labeled. However, the products may still contain allergens, such as hydroperoxides, formed by oxidative degradation of their parent terpenes. The sensitivity and selectivity of the presented LC/MS/MS method enables detection of hydroperoxides from the fragrance terpenes linalool, linalyl acetate, and limonene. However, for routine measurements, the method requires further validation.
CC :	001D08D03; 001C04B02; 002B06A
FD :	Allergène; Parfum; Monoterpène; Autooxydation; Dermatite de contact; Analyse chimique; Analyse qualitative; Electrospray; Hydroperoxyde organique; Produit réaction; p-Mentha-1,8-diène; Citrus aurantium; Bigarade; Huile essentielle; Chromatographie HPLC; Méthode couplée; Terpénoïde; Citrus sinensis; LC MS MS; Linalol; Linalol acétate; p-Menthane dérivé; Spectrométrie masse tandem; Orange douce
FG :	Rutaceae; Dicotyledones; Angiospermae; Spermatophyta
ED :	Allergen; Perfume; Monoterpene; Autoxidation; Contact dermatitis; Chemical analysis; Qualitative analysis; Electrospray; Organic hydroperoxide; Reaction product; 1,8-p-Menthadiene; Citrus aurantium; Bitter orange; Essential oil; HPLC chromatography; Coupled method; Terpenoid; Citrus sinensis; Tandem mass spectrometry; Sweet orange
EG :	Rutaceae; Dicotyledones; Angiospermae; Spermatophyta
SD :	Alergeno; Perfume; Monoterpeno; Autooxidación; Dermatitis de contacto; Análisis químico; Análisis cualitativo; Electrospray; Hidroperóxido orgánico; Producto reacción; 1,8-p-Mentadieno; Citrus aurantium; Naranja amarga; Aceite esencial; Cromatografía HPLC; Método acoplado; Terpenoide; Citrus sinensis; Espectrometría masa en tándem
LO :	INIST-17941.354000504110740070
ID :	13-0187994

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Pascal:13-0187994

Le document en format XML

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<front><div type="abstract" xml:lang="en">Different compositions of monoterpenes are utilized for their pleasant scent in cosmetics and perfumes. However, the most commonly used fragrance terpenes easily oxidize upon contact with air, forming strongly skin-sensitizing hydroperoxides. Due to their thermolability and low UV absorbance, detection methods for hydroperoxides are scarce. For the first time, a simple and sensitive method using LC/ESI-MS/MS was developed to quantitatively determine hydroperoxides from the common fragrance compounds linalool, linalyl acetate, and limonene. The method was applied to autoxidized petitgrain oil and sweet orange oil. A separation was accomplished using a C<sub>3</sub>
 column. The method LOD for the investigated hydroperoxides in the essential oils was below 0.3 μg/mL, corresponding to 0.3 ppm. For prevention purposes and according to EU regulations, concentrations in cosmetics exceeding 100 ppm in "rinse-off" and 10 ppm in "stay-on" products of linalool and limonene must be labeled. However, the products may still contain allergens, such as hydroperoxides, formed by oxidative degradation of their parent terpenes. The sensitivity and selectivity of the presented LC/MS/MS method enables detection of hydroperoxides from the fragrance terpenes linalool, linalyl acetate, and limonene. However, for routine measurements, the method requires further validation.</div>
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<fA14 i1="01"><s1>Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg</s1>
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<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Analytical Chemistry, Stockholm University</s1>
<s2>Stockholm</s2>
<s3>SWE</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA20><s1>1370-1378</s1>
</fA20>
<fA21><s1>2013</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>17941</s2>
<s5>354000504110740070</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2013 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>28 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>13-0187994</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Journal of separation science : (Print)</s0>
</fA64>
<fA66 i1="01"><s0>DEU</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Different compositions of monoterpenes are utilized for their pleasant scent in cosmetics and perfumes. However, the most commonly used fragrance terpenes easily oxidize upon contact with air, forming strongly skin-sensitizing hydroperoxides. Due to their thermolability and low UV absorbance, detection methods for hydroperoxides are scarce. For the first time, a simple and sensitive method using LC/ESI-MS/MS was developed to quantitatively determine hydroperoxides from the common fragrance compounds linalool, linalyl acetate, and limonene. The method was applied to autoxidized petitgrain oil and sweet orange oil. A separation was accomplished using a C<sub>3</sub>
 column. The method LOD for the investigated hydroperoxides in the essential oils was below 0.3 μg/mL, corresponding to 0.3 ppm. For prevention purposes and according to EU regulations, concentrations in cosmetics exceeding 100 ppm in "rinse-off" and 10 ppm in "stay-on" products of linalool and limonene must be labeled. However, the products may still contain allergens, such as hydroperoxides, formed by oxidative degradation of their parent terpenes. The sensitivity and selectivity of the presented LC/MS/MS method enables detection of hydroperoxides from the fragrance terpenes linalool, linalyl acetate, and limonene. However, for routine measurements, the method requires further validation.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>001D08D03</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>001C04B02</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B06A</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Allergène</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Allergen</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Alergeno</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Parfum</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Perfume</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Perfume</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Monoterpène</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Monoterpene</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Monoterpeno</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Autooxydation</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Autoxidation</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Autooxidación</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Dermatite de contact</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Contact dermatitis</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Dermatitis de contacto</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Analyse chimique</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Chemical analysis</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Análisis químico</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Analyse qualitative</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Qualitative analysis</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Análisis cualitativo</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Electrospray</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Electrospray</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Electrospray</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Hydroperoxyde organique</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Organic hydroperoxide</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Hidroperóxido orgánico</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Produit réaction</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Reaction product</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Producto reacción</s0>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>p-Mentha-1,8-diène</s0>
<s2>NK</s2>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>1,8-p-Menthadiene</s0>
<s2>NK</s2>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>1,8-p-Mentadieno</s0>
<s2>NK</s2>
<s5>11</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Citrus aurantium</s0>
<s2>NS</s2>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Citrus aurantium</s0>
<s2>NS</s2>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Citrus aurantium</s0>
<s2>NS</s2>
<s5>12</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Bigarade</s0>
<s5>13</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Bitter orange</s0>
<s5>13</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Naranja amarga</s0>
<s5>13</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Huile essentielle</s0>
<s5>14</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Essential oil</s0>
<s5>14</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Aceite esencial</s0>
<s5>14</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE"><s0>Chromatographie HPLC</s0>
<s5>32</s5>
</fC03>
<fC03 i1="15" i2="X" l="ENG"><s0>HPLC chromatography</s0>
<s5>32</s5>
</fC03>
<fC03 i1="15" i2="X" l="SPA"><s0>Cromatografía HPLC</s0>
<s5>32</s5>
</fC03>
<fC03 i1="16" i2="X" l="FRE"><s0>Méthode couplée</s0>
<s5>33</s5>
</fC03>
<fC03 i1="16" i2="X" l="ENG"><s0>Coupled method</s0>
<s5>33</s5>
</fC03>
<fC03 i1="16" i2="X" l="SPA"><s0>Método acoplado</s0>
<s5>33</s5>
</fC03>
<fC03 i1="17" i2="X" l="FRE"><s0>Terpénoïde</s0>
<s2>FX</s2>
<s5>35</s5>
</fC03>
<fC03 i1="17" i2="X" l="ENG"><s0>Terpenoid</s0>
<s2>FX</s2>
<s5>35</s5>
</fC03>
<fC03 i1="17" i2="X" l="SPA"><s0>Terpenoide</s0>
<s2>FX</s2>
<s5>35</s5>
</fC03>
<fC03 i1="18" i2="X" l="FRE"><s0>Citrus sinensis</s0>
<s2>NS</s2>
<s5>41</s5>
</fC03>
<fC03 i1="18" i2="X" l="ENG"><s0>Citrus sinensis</s0>
<s2>NS</s2>
<s5>41</s5>
</fC03>
<fC03 i1="18" i2="X" l="SPA"><s0>Citrus sinensis</s0>
<s2>NS</s2>
<s5>41</s5>
</fC03>
<fC03 i1="19" i2="X" l="FRE"><s0>LC MS MS</s0>
<s4>INC</s4>
<s5>76</s5>
</fC03>
<fC03 i1="20" i2="X" l="FRE"><s0>Linalol</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>77</s5>
</fC03>
<fC03 i1="21" i2="X" l="FRE"><s0>Linalol acétate</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>78</s5>
</fC03>
<fC03 i1="22" i2="X" l="FRE"><s0>p-Menthane dérivé</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>91</s5>
</fC03>
<fC03 i1="23" i2="X" l="FRE"><s0>Spectrométrie masse tandem</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="23" i2="X" l="ENG"><s0>Tandem mass spectrometry</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="23" i2="X" l="SPA"><s0>Espectrometría masa en tándem</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="24" i2="X" l="FRE"><s0>Orange douce</s0>
<s4>CD</s4>
<s5>97</s5>
</fC03>
<fC03 i1="24" i2="X" l="ENG"><s0>Sweet orange</s0>
<s4>CD</s4>
<s5>97</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Rutaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Rutaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Rutaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fN21><s1>168</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 13-0187994 INIST</NO>
<ET>A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry</ET>
<AU>RUDBÄCK (Johanna); ISLAM (Nurul); NILSSON (Ulrika); KARLBERG (Ann-Therese)</AU>
<AF>Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg/Gothenburg/Suède (1 aut., 2 aut., 4 aut.); Department of Analytical Chemistry, Stockholm University/Stockholm/Suède (3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of separation science : (Print); ISSN 1615-9306; Allemagne; Da. 2013; Vol. 36; No. 8; Pp. 1370-1378; Bibl. 28 ref.</SO>
<LA>Anglais</LA>
<EA>Different compositions of monoterpenes are utilized for their pleasant scent in cosmetics and perfumes. However, the most commonly used fragrance terpenes easily oxidize upon contact with air, forming strongly skin-sensitizing hydroperoxides. Due to their thermolability and low UV absorbance, detection methods for hydroperoxides are scarce. For the first time, a simple and sensitive method using LC/ESI-MS/MS was developed to quantitatively determine hydroperoxides from the common fragrance compounds linalool, linalyl acetate, and limonene. The method was applied to autoxidized petitgrain oil and sweet orange oil. A separation was accomplished using a C<sub>3</sub>
 column. The method LOD for the investigated hydroperoxides in the essential oils was below 0.3 μg/mL, corresponding to 0.3 ppm. For prevention purposes and according to EU regulations, concentrations in cosmetics exceeding 100 ppm in "rinse-off" and 10 ppm in "stay-on" products of linalool and limonene must be labeled. However, the products may still contain allergens, such as hydroperoxides, formed by oxidative degradation of their parent terpenes. The sensitivity and selectivity of the presented LC/MS/MS method enables detection of hydroperoxides from the fragrance terpenes linalool, linalyl acetate, and limonene. However, for routine measurements, the method requires further validation.</EA>
<CC>001D08D03; 001C04B02; 002B06A</CC>
<FD>Allergène; Parfum; Monoterpène; Autooxydation; Dermatite de contact; Analyse chimique; Analyse qualitative; Electrospray; Hydroperoxyde organique; Produit réaction; p-Mentha-1,8-diène; Citrus aurantium; Bigarade; Huile essentielle; Chromatographie HPLC; Méthode couplée; Terpénoïde; Citrus sinensis; LC MS MS; Linalol; Linalol acétate; p-Menthane dérivé; Spectrométrie masse tandem; Orange douce</FD>
<FG>Rutaceae; Dicotyledones; Angiospermae; Spermatophyta</FG>
<ED>Allergen; Perfume; Monoterpene; Autoxidation; Contact dermatitis; Chemical analysis; Qualitative analysis; Electrospray; Organic hydroperoxide; Reaction product; 1,8-p-Menthadiene; Citrus aurantium; Bitter orange; Essential oil; HPLC chromatography; Coupled method; Terpenoid; Citrus sinensis; Tandem mass spectrometry; Sweet orange</ED>
<EG>Rutaceae; Dicotyledones; Angiospermae; Spermatophyta</EG>
<SD>Alergeno; Perfume; Monoterpeno; Autooxidación; Dermatitis de contacto; Análisis químico; Análisis cualitativo; Electrospray; Hidroperóxido orgánico; Producto reacción; 1,8-p-Mentadieno; Citrus aurantium; Naranja amarga; Aceite esencial; Cromatografía HPLC; Método acoplado; Terpenoide; Citrus sinensis; Espectrometría masa en tándem</SD>
<LO>INIST-17941.354000504110740070</LO>
<ID>13-0187994</ID>
</server>
</inist>
</record>

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A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry

A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry

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