A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry
Identifieur interne : 000058 ( PascalFrancis/Corpus ); précédent : 000057; suivant : 000059A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry
Auteurs : Johanna Rudb Ck ; Nurul Islam ; Ulrika Nilsson ; Ann-Therese KarlbergSource :
- Journal of separation science : (Print) [ 1615-9306 ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Allergène, Parfum, Monoterpène, Autooxydation, Dermatite de contact, Analyse chimique, Analyse qualitative, Electrospray, Hydroperoxyde organique, Produit réaction, p-Mentha-1,8-diène, Citrus aurantium, Bigarade, Huile essentielle, Chromatographie HPLC, Méthode couplée, Terpénoïde, Citrus sinensis, LC MS MS, Linalol, Linalol acétate, p-Menthane dérivé, Spectrométrie masse tandem, Orange douce.
English descriptors
- KwdEn :
- 1,8-p-Menthadiene, Allergen, Autoxidation, Bitter orange, Chemical analysis, Citrus aurantium, Citrus sinensis, Contact dermatitis, Coupled method, Electrospray, Essential oil, HPLC chromatography, Monoterpene, Organic hydroperoxide, Perfume, Qualitative analysis, Reaction product, Sweet orange, Tandem mass spectrometry, Terpenoid.
Abstract
Different compositions of monoterpenes are utilized for their pleasant scent in cosmetics and perfumes. However, the most commonly used fragrance terpenes easily oxidize upon contact with air, forming strongly skin-sensitizing hydroperoxides. Due to their thermolability and low UV absorbance, detection methods for hydroperoxides are scarce. For the first time, a simple and sensitive method using LC/ESI-MS/MS was developed to quantitatively determine hydroperoxides from the common fragrance compounds linalool, linalyl acetate, and limonene. The method was applied to autoxidized petitgrain oil and sweet orange oil. A separation was accomplished using a C3 column. The method LOD for the investigated hydroperoxides in the essential oils was below 0.3 μg/mL, corresponding to 0.3 ppm. For prevention purposes and according to EU regulations, concentrations in cosmetics exceeding 100 ppm in "rinse-off" and 10 ppm in "stay-on" products of linalool and limonene must be labeled. However, the products may still contain allergens, such as hydroperoxides, formed by oxidative degradation of their parent terpenes. The sensitivity and selectivity of the presented LC/MS/MS method enables detection of hydroperoxides from the fragrance terpenes linalool, linalyl acetate, and limonene. However, for routine measurements, the method requires further validation.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 13-0187994 INIST |
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ET : | A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry |
AU : | RUDBÄCK (Johanna); ISLAM (Nurul); NILSSON (Ulrika); KARLBERG (Ann-Therese) |
AF : | Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg/Gothenburg/Suède (1 aut., 2 aut., 4 aut.); Department of Analytical Chemistry, Stockholm University/Stockholm/Suède (3 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Journal of separation science : (Print); ISSN 1615-9306; Allemagne; Da. 2013; Vol. 36; No. 8; Pp. 1370-1378; Bibl. 28 ref. |
LA : | Anglais |
EA : | Different compositions of monoterpenes are utilized for their pleasant scent in cosmetics and perfumes. However, the most commonly used fragrance terpenes easily oxidize upon contact with air, forming strongly skin-sensitizing hydroperoxides. Due to their thermolability and low UV absorbance, detection methods for hydroperoxides are scarce. For the first time, a simple and sensitive method using LC/ESI-MS/MS was developed to quantitatively determine hydroperoxides from the common fragrance compounds linalool, linalyl acetate, and limonene. The method was applied to autoxidized petitgrain oil and sweet orange oil. A separation was accomplished using a C3 column. The method LOD for the investigated hydroperoxides in the essential oils was below 0.3 μg/mL, corresponding to 0.3 ppm. For prevention purposes and according to EU regulations, concentrations in cosmetics exceeding 100 ppm in "rinse-off" and 10 ppm in "stay-on" products of linalool and limonene must be labeled. However, the products may still contain allergens, such as hydroperoxides, formed by oxidative degradation of their parent terpenes. The sensitivity and selectivity of the presented LC/MS/MS method enables detection of hydroperoxides from the fragrance terpenes linalool, linalyl acetate, and limonene. However, for routine measurements, the method requires further validation. |
CC : | 001D08D03; 001C04B02; 002B06A |
FD : | Allergène; Parfum; Monoterpène; Autooxydation; Dermatite de contact; Analyse chimique; Analyse qualitative; Electrospray; Hydroperoxyde organique; Produit réaction; p-Mentha-1,8-diène; Citrus aurantium; Bigarade; Huile essentielle; Chromatographie HPLC; Méthode couplée; Terpénoïde; Citrus sinensis; LC MS MS; Linalol; Linalol acétate; p-Menthane dérivé; Spectrométrie masse tandem; Orange douce |
FG : | Rutaceae; Dicotyledones; Angiospermae; Spermatophyta |
ED : | Allergen; Perfume; Monoterpene; Autoxidation; Contact dermatitis; Chemical analysis; Qualitative analysis; Electrospray; Organic hydroperoxide; Reaction product; 1,8-p-Menthadiene; Citrus aurantium; Bitter orange; Essential oil; HPLC chromatography; Coupled method; Terpenoid; Citrus sinensis; Tandem mass spectrometry; Sweet orange |
EG : | Rutaceae; Dicotyledones; Angiospermae; Spermatophyta |
SD : | Alergeno; Perfume; Monoterpeno; Autooxidación; Dermatitis de contacto; Análisis químico; Análisis cualitativo; Electrospray; Hidroperóxido orgánico; Producto reacción; 1,8-p-Mentadieno; Citrus aurantium; Naranja amarga; Aceite esencial; Cromatografía HPLC; Método acoplado; Terpenoide; Citrus sinensis; Espectrometría masa en tándem |
LO : | INIST-17941.354000504110740070 |
ID : | 13-0187994 |
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Pascal:13-0187994Le document en format XML
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<term>Analyse chimique</term>
<term>Analyse qualitative</term>
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<front><div type="abstract" xml:lang="en">Different compositions of monoterpenes are utilized for their pleasant scent in cosmetics and perfumes. However, the most commonly used fragrance terpenes easily oxidize upon contact with air, forming strongly skin-sensitizing hydroperoxides. Due to their thermolability and low UV absorbance, detection methods for hydroperoxides are scarce. For the first time, a simple and sensitive method using LC/ESI-MS/MS was developed to quantitatively determine hydroperoxides from the common fragrance compounds linalool, linalyl acetate, and limonene. The method was applied to autoxidized petitgrain oil and sweet orange oil. A separation was accomplished using a C<sub>3</sub>
column. The method LOD for the investigated hydroperoxides in the essential oils was below 0.3 μg/mL, corresponding to 0.3 ppm. For prevention purposes and according to EU regulations, concentrations in cosmetics exceeding 100 ppm in "rinse-off" and 10 ppm in "stay-on" products of linalool and limonene must be labeled. However, the products may still contain allergens, such as hydroperoxides, formed by oxidative degradation of their parent terpenes. The sensitivity and selectivity of the presented LC/MS/MS method enables detection of hydroperoxides from the fragrance terpenes linalool, linalyl acetate, and limonene. However, for routine measurements, the method requires further validation.</div>
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<fC01 i1="01" l="ENG"><s0>Different compositions of monoterpenes are utilized for their pleasant scent in cosmetics and perfumes. However, the most commonly used fragrance terpenes easily oxidize upon contact with air, forming strongly skin-sensitizing hydroperoxides. Due to their thermolability and low UV absorbance, detection methods for hydroperoxides are scarce. For the first time, a simple and sensitive method using LC/ESI-MS/MS was developed to quantitatively determine hydroperoxides from the common fragrance compounds linalool, linalyl acetate, and limonene. The method was applied to autoxidized petitgrain oil and sweet orange oil. A separation was accomplished using a C<sub>3</sub>
column. The method LOD for the investigated hydroperoxides in the essential oils was below 0.3 μg/mL, corresponding to 0.3 ppm. For prevention purposes and according to EU regulations, concentrations in cosmetics exceeding 100 ppm in "rinse-off" and 10 ppm in "stay-on" products of linalool and limonene must be labeled. However, the products may still contain allergens, such as hydroperoxides, formed by oxidative degradation of their parent terpenes. The sensitivity and selectivity of the presented LC/MS/MS method enables detection of hydroperoxides from the fragrance terpenes linalool, linalyl acetate, and limonene. However, for routine measurements, the method requires further validation.</s0>
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<fC03 i1="03" i2="X" l="SPA"><s0>Monoterpeno</s0>
<s5>03</s5>
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<s5>04</s5>
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<s5>04</s5>
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<s5>04</s5>
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<s5>32</s5>
</fC03>
<fC03 i1="16" i2="X" l="FRE"><s0>Méthode couplée</s0>
<s5>33</s5>
</fC03>
<fC03 i1="16" i2="X" l="ENG"><s0>Coupled method</s0>
<s5>33</s5>
</fC03>
<fC03 i1="16" i2="X" l="SPA"><s0>Método acoplado</s0>
<s5>33</s5>
</fC03>
<fC03 i1="17" i2="X" l="FRE"><s0>Terpénoïde</s0>
<s2>FX</s2>
<s5>35</s5>
</fC03>
<fC03 i1="17" i2="X" l="ENG"><s0>Terpenoid</s0>
<s2>FX</s2>
<s5>35</s5>
</fC03>
<fC03 i1="17" i2="X" l="SPA"><s0>Terpenoide</s0>
<s2>FX</s2>
<s5>35</s5>
</fC03>
<fC03 i1="18" i2="X" l="FRE"><s0>Citrus sinensis</s0>
<s2>NS</s2>
<s5>41</s5>
</fC03>
<fC03 i1="18" i2="X" l="ENG"><s0>Citrus sinensis</s0>
<s2>NS</s2>
<s5>41</s5>
</fC03>
<fC03 i1="18" i2="X" l="SPA"><s0>Citrus sinensis</s0>
<s2>NS</s2>
<s5>41</s5>
</fC03>
<fC03 i1="19" i2="X" l="FRE"><s0>LC MS MS</s0>
<s4>INC</s4>
<s5>76</s5>
</fC03>
<fC03 i1="20" i2="X" l="FRE"><s0>Linalol</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>77</s5>
</fC03>
<fC03 i1="21" i2="X" l="FRE"><s0>Linalol acétate</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>78</s5>
</fC03>
<fC03 i1="22" i2="X" l="FRE"><s0>p-Menthane dérivé</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>91</s5>
</fC03>
<fC03 i1="23" i2="X" l="FRE"><s0>Spectrométrie masse tandem</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="23" i2="X" l="ENG"><s0>Tandem mass spectrometry</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="23" i2="X" l="SPA"><s0>Espectrometría masa en tándem</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="24" i2="X" l="FRE"><s0>Orange douce</s0>
<s4>CD</s4>
<s5>97</s5>
</fC03>
<fC03 i1="24" i2="X" l="ENG"><s0>Sweet orange</s0>
<s4>CD</s4>
<s5>97</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Rutaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Rutaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Rutaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fN21><s1>168</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 13-0187994 INIST</NO>
<ET>A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry</ET>
<AU>RUDBÄCK (Johanna); ISLAM (Nurul); NILSSON (Ulrika); KARLBERG (Ann-Therese)</AU>
<AF>Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg/Gothenburg/Suède (1 aut., 2 aut., 4 aut.); Department of Analytical Chemistry, Stockholm University/Stockholm/Suède (3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of separation science : (Print); ISSN 1615-9306; Allemagne; Da. 2013; Vol. 36; No. 8; Pp. 1370-1378; Bibl. 28 ref.</SO>
<LA>Anglais</LA>
<EA>Different compositions of monoterpenes are utilized for their pleasant scent in cosmetics and perfumes. However, the most commonly used fragrance terpenes easily oxidize upon contact with air, forming strongly skin-sensitizing hydroperoxides. Due to their thermolability and low UV absorbance, detection methods for hydroperoxides are scarce. For the first time, a simple and sensitive method using LC/ESI-MS/MS was developed to quantitatively determine hydroperoxides from the common fragrance compounds linalool, linalyl acetate, and limonene. The method was applied to autoxidized petitgrain oil and sweet orange oil. A separation was accomplished using a C<sub>3</sub>
column. The method LOD for the investigated hydroperoxides in the essential oils was below 0.3 μg/mL, corresponding to 0.3 ppm. For prevention purposes and according to EU regulations, concentrations in cosmetics exceeding 100 ppm in "rinse-off" and 10 ppm in "stay-on" products of linalool and limonene must be labeled. However, the products may still contain allergens, such as hydroperoxides, formed by oxidative degradation of their parent terpenes. The sensitivity and selectivity of the presented LC/MS/MS method enables detection of hydroperoxides from the fragrance terpenes linalool, linalyl acetate, and limonene. However, for routine measurements, the method requires further validation.</EA>
<CC>001D08D03; 001C04B02; 002B06A</CC>
<FD>Allergène; Parfum; Monoterpène; Autooxydation; Dermatite de contact; Analyse chimique; Analyse qualitative; Electrospray; Hydroperoxyde organique; Produit réaction; p-Mentha-1,8-diène; Citrus aurantium; Bigarade; Huile essentielle; Chromatographie HPLC; Méthode couplée; Terpénoïde; Citrus sinensis; LC MS MS; Linalol; Linalol acétate; p-Menthane dérivé; Spectrométrie masse tandem; Orange douce</FD>
<FG>Rutaceae; Dicotyledones; Angiospermae; Spermatophyta</FG>
<ED>Allergen; Perfume; Monoterpene; Autoxidation; Contact dermatitis; Chemical analysis; Qualitative analysis; Electrospray; Organic hydroperoxide; Reaction product; 1,8-p-Menthadiene; Citrus aurantium; Bitter orange; Essential oil; HPLC chromatography; Coupled method; Terpenoid; Citrus sinensis; Tandem mass spectrometry; Sweet orange</ED>
<EG>Rutaceae; Dicotyledones; Angiospermae; Spermatophyta</EG>
<SD>Alergeno; Perfume; Monoterpeno; Autooxidación; Dermatitis de contacto; Análisis químico; Análisis cualitativo; Electrospray; Hidroperóxido orgánico; Producto reacción; 1,8-p-Mentadieno; Citrus aurantium; Naranja amarga; Aceite esencial; Cromatografía HPLC; Método acoplado; Terpenoide; Citrus sinensis; Espectrometría masa en tándem</SD>
<LO>INIST-17941.354000504110740070</LO>
<ID>13-0187994</ID>
</server>
</inist>
</record>
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