Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress
Identifieur interne : 000087 ( PascalFrancis/Checkpoint ); précédent : 000086; suivant : 000088Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress
Auteurs : Zong-Tsi Chen [Taïwan] ; Heuy-Ling Chu [Taïwan] ; Charng-Cherng Chyau [Taïwan] ; Chin-Chen Chu [Taïwan] ; Pin-Der Duh [Taïwan]Source :
- Food chemistry [ 0308-8146 ] ; 2012.
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Abstract
Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress were investigated. According to HPLC-DAD and HPLC-MS/MS analysis, hesperidin (HD), hesperetin (HT), nobiletin (NT), and tangeretin (TT) were present in water extracts of sweet orange peel (WESP). The cytotoxic effect in 0.2 mM t-BHP-induced HepG2 cells was inhibited by WESP and their bioactive compounds. The protective effect of WESP and their bioactive compounds in 0.2 mM t-BHP-induced HepG2 cells may be associated with positive regulation of GSH levels and antioxidant enzymes, decrease in ROS formation and TBARS generation, increase in the mitochondria membrane potential and Bcl-2/Bax ratio, as well as decrease in caspase-3 activation. Overall, WESP displayed a significant cytoprotective effect against oxidative stress, which may be most likely because of the phenolics-related bioactive compounds in WESP, leading to maintenance of the normal redox status of cells.
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Section 1, Pao-An, Jen-Te District</s1><s2>Tainan</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Tainan</wicri:noRegion></affiliation></author><author><name sortKey="Chyau, Charng Cherng" sort="Chyau, Charng Cherng" uniqKey="Chyau C" first="Charng-Cherng" last="Chyau">Charng-Cherng Chyau</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Research Institute of Biotechnology, Hungkuang University, 34 Chung-Chie Road, Shalu County</s1><s2>Taichung</s2><s3>TWN</s3><sZ>3 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Chu, Chin Chen" sort="Chu, Chin Chen" uniqKey="Chu C" first="Chin-Chen" last="Chu">Chin-Chen Chu</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Anesthesiology, Chi-Mei Medical Center</s1><s2>Tainan</s2><s3>TWN</s3><sZ>4 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Tainan</wicri:noRegion></affiliation></author><author><name sortKey="Duh, Pin Der" sort="Duh, Pin Der" uniqKey="Duh P" first="Pin-Der" last="Duh">Pin-Der Duh</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Food Science and Technology, Chia Nan University of Pharmacy and Science, 60 Erh-Jen Road, Section 1, Pao-An, Jen-Te District</s1><s2>Tainan</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Tainan</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Food chemistry</title><title level="j" type="abbreviated">Food chem.</title><idno type="ISSN">0308-8146</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Food chemistry</title><title level="j" type="abbreviated">Food chem.</title><idno type="ISSN">0308-8146</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Citrus sinensis</term><term>Hesperidin</term><term>Orange</term><term>Oxidative stress</term><term>Peel</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Orange</term><term>Citrus sinensis</term><term>Pelure</term><term>Stress oxydatif</term><term>Hespéridine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress were investigated. According to HPLC-DAD and HPLC-MS/MS analysis, hesperidin (HD), hesperetin (HT), nobiletin (NT), and tangeretin (TT) were present in water extracts of sweet orange peel (WESP). The cytotoxic effect in 0.2 mM t-BHP-induced HepG2 cells was inhibited by WESP and their bioactive compounds. The protective effect of WESP and their bioactive compounds in 0.2 mM t-BHP-induced HepG2 cells may be associated with positive regulation of GSH levels and antioxidant enzymes, decrease in ROS formation and TBARS generation, increase in the mitochondria membrane potential and Bcl-2/Bax ratio, as well as decrease in caspase-3 activation. 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All rights reserved.</s1></fA44><fA45><s0>3/4 p.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0394264</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Food chemistry</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress were investigated. According to HPLC-DAD and HPLC-MS/MS analysis, hesperidin (HD), hesperetin (HT), nobiletin (NT), and tangeretin (TT) were present in water extracts of sweet orange peel (WESP). The cytotoxic effect in 0.2 mM t-BHP-induced HepG2 cells was inhibited by WESP and their bioactive compounds. The protective effect of WESP and their bioactive compounds in 0.2 mM t-BHP-induced HepG2 cells may be associated with positive regulation of GSH levels and antioxidant enzymes, decrease in ROS formation and TBARS generation, increase in the mitochondria membrane potential and Bcl-2/Bax ratio, as well as decrease in caspase-3 activation. 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