Antiangiogenic and antiproliferative effects of black pomegranate peel extract on melanoma cell line
Identifieur interne : 001D65 ( Ncbi/Merge ); précédent : 001D64; suivant : 001D66Antiangiogenic and antiproliferative effects of black pomegranate peel extract on melanoma cell line
Auteurs : N. Dana ; Sh. Haghjooy Javanmard ; L. RafieeSource :
- Research in Pharmaceutical Sciences [ 1735-5362 ] ; 2015.
Abstract
In the present study possible effects of black pomegranate peel extract (PPE) on the B16F10 melanoma cells proliferation and Human Umbilical Vein Endothelial Cells (HUVECs) angiogenesis were investigated. PPE was added into the cell lines (B16F10 and HUVECs) media with different concentrations (10–450 μg/ml). After 48 h, the cell survival was measured by 3-(Dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay. Angiogenesis was investigated by matrigel assay (PPE (200, 300, 400 μg/ml)); HUVECs, vascular endothelial growth factor (VEGF) mRNA expression was detected by quantitative reverse transcriptase–polymerase chain reaction (QRT-PCR) assay. VEGF concentration in culture medium of HUVECs was determined by enzyme-linked immunosorbent assay (ELISA). PPE had positive anti proliferative effect on melanoma cells in a dose-dependent manner, but not on HUVECs. The matrigel assay results indicated that PPE significantly inhibited length, size and junction of the tube like structures (
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PubMed: 26487888
PubMed Central: 4584450
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<front><div type="abstract" xml:lang="en"><p>In the present study possible effects of black pomegranate peel extract (PPE) on the B16F10 melanoma cells proliferation and Human Umbilical Vein Endothelial Cells (HUVECs) angiogenesis were investigated. PPE was added into the cell lines (B16F10 and HUVECs) media with different concentrations (10–450 μg/ml). After 48 h, the cell survival was measured by 3-(Dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay. Angiogenesis was investigated by matrigel assay (PPE (200, 300, 400 μg/ml)); HUVECs, vascular endothelial growth factor (VEGF) mRNA expression was detected by quantitative reverse transcriptase–polymerase chain reaction (QRT-PCR) assay. VEGF concentration in culture medium of HUVECs was determined by enzyme-linked immunosorbent assay (ELISA). PPE had positive anti proliferative effect on melanoma cells in a dose-dependent manner, but not on HUVECs. The matrigel assay results indicated that PPE significantly inhibited length, size and junction of the tube like structures (<italic>P<</italic>
0.05). VEGF mRNA expression and concentration levels in culture medium of PPE treated HUVECs reduced significantly in a concentration-dependent manner (<italic>P<</italic>
0.05). Simultaneous inhibition of melanoma cell proliferation and angiogenesis proposed that, PPE can be a good candidate against melanoma development. Based on the results, PPE could effectively suppress angiogenesis potentially through a VEGF dependent mechanism. Further studies are needed to confirm these results.</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Res Pharm Sci</journal-id>
<journal-id journal-id-type="iso-abbrev">Res Pharm Sci</journal-id>
<journal-id journal-id-type="publisher-id">RPS</journal-id>
<journal-title-group><journal-title>Research in Pharmaceutical Sciences</journal-title>
</journal-title-group>
<issn pub-type="ppub">1735-5362</issn>
<issn pub-type="epub">1735-9414</issn>
<publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name>
<publisher-loc>India</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26487888</article-id>
<article-id pub-id-type="pmc">4584450</article-id>
<article-id pub-id-type="publisher-id">RPS-10-117</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Antiangiogenic and antiproliferative effects of black pomegranate peel extract on melanoma cell line</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Dana</surname>
<given-names>N.</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Javanmard</surname>
<given-names>Sh. Haghjooy</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rafiee</surname>
<given-names>L.</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
</contrib-group>
<aff id="aff1"><italic>Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, I.R. Iran</italic>
</aff>
<author-notes><corresp id="cor1"><label>*</label>
Corresponding author: Sh. Haghjooy javanmard Tel: 0098 31 36692836, Fax: 0098 31 36692836 Email: <email xlink:href="sh_haghjoo@med.mui.ac.ir">sh_haghjoo@med.mui.ac.ir</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><season>Mar-Apr</season>
<year>2015</year>
</pub-date>
<volume>10</volume>
<issue>2</issue>
<fpage>117</fpage>
<lpage>124</lpage>
<history><date date-type="received"><month>3</month>
<year>2014</year>
</date>
<date date-type="accepted"><month>5</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>Copyright: © Research in Pharmaceutical Sciences</copyright-statement>
<copyright-year>2015</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.</license-p>
</license>
</permissions>
<abstract><p>In the present study possible effects of black pomegranate peel extract (PPE) on the B16F10 melanoma cells proliferation and Human Umbilical Vein Endothelial Cells (HUVECs) angiogenesis were investigated. PPE was added into the cell lines (B16F10 and HUVECs) media with different concentrations (10–450 μg/ml). After 48 h, the cell survival was measured by 3-(Dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay. Angiogenesis was investigated by matrigel assay (PPE (200, 300, 400 μg/ml)); HUVECs, vascular endothelial growth factor (VEGF) mRNA expression was detected by quantitative reverse transcriptase–polymerase chain reaction (QRT-PCR) assay. VEGF concentration in culture medium of HUVECs was determined by enzyme-linked immunosorbent assay (ELISA). PPE had positive anti proliferative effect on melanoma cells in a dose-dependent manner, but not on HUVECs. The matrigel assay results indicated that PPE significantly inhibited length, size and junction of the tube like structures (<italic>P<</italic>
0.05). VEGF mRNA expression and concentration levels in culture medium of PPE treated HUVECs reduced significantly in a concentration-dependent manner (<italic>P<</italic>
0.05). Simultaneous inhibition of melanoma cell proliferation and angiogenesis proposed that, PPE can be a good candidate against melanoma development. Based on the results, PPE could effectively suppress angiogenesis potentially through a VEGF dependent mechanism. Further studies are needed to confirm these results.</p>
</abstract>
<kwd-group><kwd>Pomegranate</kwd>
<kwd>Human Umbilical Vein Endothelial Cells</kwd>
<kwd>Angiogenesis</kwd>
<kwd>B16F10 melanoma</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Dana, N" sort="Dana, N" uniqKey="Dana N" first="N." last="Dana">N. Dana</name>
<name sortKey="Javanmard, Sh Haghjooy" sort="Javanmard, Sh Haghjooy" uniqKey="Javanmard S" first="Sh. Haghjooy" last="Javanmard">Sh. Haghjooy Javanmard</name>
<name sortKey="Rafiee, L" sort="Rafiee, L" uniqKey="Rafiee L" first="L." last="Rafiee">L. Rafiee</name>
</noCountry>
</tree>
</affiliations>
</record>
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