Orange juice (poly)phenols are highly bioavailable in humans.
Identifieur interne : 001871 ( Ncbi/Merge ); précédent : 001870; suivant : 001872Orange juice (poly)phenols are highly bioavailable in humans.
Auteurs : Gema Pereira-Caro [Royaume-Uni] ; Gina Borges [Royaume-Uni] ; Justin Van Der Hooft [Royaume-Uni] ; Michael N. Clifford [Royaume-Uni] ; Daniele Del Rio [Royaume-Uni] ; Michael E J. Lean [Royaume-Uni] ; Susan A. Roberts [Royaume-Uni] ; Michele B. Kellerhals [Royaume-Uni] ; Alan Crozier [Royaume-Uni]Source :
- The American journal of clinical nutrition [ 1938-3207 ] ; 2014.
English descriptors
- KwdEn :
- Adult, Beverages (analysis), Biological Availability, Body Mass Index, Chromatography, High Pressure Liquid, Citrus sinensis (chemistry), Colon (drug effects), Colon (metabolism), Cross-Over Studies, Female, Flavanones (pharmacokinetics), Flavanones (urine), Fruit (chemistry), Gas Chromatography-Mass Spectrometry, Glucuronides (pharmacokinetics), Glucuronides (urine), Healthy Volunteers, Hesperidin (analogs & derivatives), Hesperidin (pharmacokinetics), Hesperidin (urine), Humans, Limit of Detection, Linear Models, Male, Middle Aged, Polyphenols (pharmacokinetics), Polyphenols (urine), Retrospective Studies, Young Adult.
- MESH :
- chemical , analogs & derivatives : Hesperidin.
- chemical , pharmacokinetics : Flavanones, Glucuronides, Hesperidin, Polyphenols.
- analysis : Beverages.
- chemistry : Citrus sinensis, Fruit.
- drug effects : Colon.
- metabolism : Colon.
- chemical , urine : Flavanones, Glucuronides, Hesperidin, Polyphenols.
- Adult, Biological Availability, Body Mass Index, Chromatography, High Pressure Liquid, Cross-Over Studies, Female, Gas Chromatography-Mass Spectrometry, Healthy Volunteers, Humans, Limit of Detection, Linear Models, Male, Middle Aged, Retrospective Studies, Young Adult.
Abstract
We assessed the bioavailability of orange juice (poly)phenols by monitoring urinary flavanone metabolites and ring fission catabolites produced by the action of the colonic microbiota.
DOI: 10.3945/ajcn.114.090282
PubMed: 25332336
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- to stream PubMed, to step Corpus: 000276
- to stream PubMed, to step Curation: 000276
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pubmed:25332336Le document en format XML
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<author><name sortKey="Pereira Caro, Gema" sort="Pereira Caro, Gema" uniqKey="Pereira Caro G" first="Gema" last="Pereira-Caro">Gema Pereira-Caro</name>
<affiliation wicri:level="4"><nlm:affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</nlm:affiliation>
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<author><name sortKey="Borges, Gina" sort="Borges, Gina" uniqKey="Borges G" first="Gina" last="Borges">Gina Borges</name>
<affiliation wicri:level="4"><nlm:affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</nlm:affiliation>
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<author><name sortKey="Van Der Hooft, Justin" sort="Van Der Hooft, Justin" uniqKey="Van Der Hooft J" first="Justin" last="Van Der Hooft">Justin Van Der Hooft</name>
<affiliation wicri:level="4"><nlm:affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</nlm:affiliation>
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<author><name sortKey="Clifford, Michael N" sort="Clifford, Michael N" uniqKey="Clifford M" first="Michael N" last="Clifford">Michael N. Clifford</name>
<affiliation wicri:level="4"><nlm:affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</nlm:affiliation>
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<author><name sortKey="Del Rio, Daniele" sort="Del Rio, Daniele" uniqKey="Del Rio D" first="Daniele" last="Del Rio">Daniele Del Rio</name>
<affiliation wicri:level="4"><nlm:affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</nlm:affiliation>
<orgName type="university">Université de Glasgow</orgName>
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<author><name sortKey="Lean, Michael E J" sort="Lean, Michael E J" uniqKey="Lean M" first="Michael E J" last="Lean">Michael E J. Lean</name>
<affiliation wicri:level="4"><nlm:affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</nlm:affiliation>
<orgName type="university">Université de Glasgow</orgName>
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<author><name sortKey="Roberts, Susan A" sort="Roberts, Susan A" uniqKey="Roberts S" first="Susan A" last="Roberts">Susan A. Roberts</name>
<affiliation wicri:level="4"><nlm:affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</nlm:affiliation>
<orgName type="university">Université de Glasgow</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
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<author><name sortKey="Kellerhals, Michele B" sort="Kellerhals, Michele B" uniqKey="Kellerhals M" first="Michele B" last="Kellerhals">Michele B. Kellerhals</name>
<affiliation wicri:level="4"><nlm:affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</nlm:affiliation>
<orgName type="university">Université de Glasgow</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
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<author><name sortKey="Crozier, Alan" sort="Crozier, Alan" uniqKey="Crozier A" first="Alan" last="Crozier">Alan Crozier</name>
<affiliation wicri:level="4"><nlm:affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</nlm:affiliation>
<orgName type="university">Université de Glasgow</orgName>
<country>Royaume-Uni</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Orange juice (poly)phenols are highly bioavailable in humans.</title>
<author><name sortKey="Pereira Caro, Gema" sort="Pereira Caro, Gema" uniqKey="Pereira Caro G" first="Gema" last="Pereira-Caro">Gema Pereira-Caro</name>
<affiliation wicri:level="4"><nlm:affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</nlm:affiliation>
<orgName type="university">Université de Glasgow</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
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<author><name sortKey="Borges, Gina" sort="Borges, Gina" uniqKey="Borges G" first="Gina" last="Borges">Gina Borges</name>
<affiliation wicri:level="4"><nlm:affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</nlm:affiliation>
<orgName type="university">Université de Glasgow</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
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<author><name sortKey="Van Der Hooft, Justin" sort="Van Der Hooft, Justin" uniqKey="Van Der Hooft J" first="Justin" last="Van Der Hooft">Justin Van Der Hooft</name>
<affiliation wicri:level="4"><nlm:affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</nlm:affiliation>
<orgName type="university">Université de Glasgow</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
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<author><name sortKey="Clifford, Michael N" sort="Clifford, Michael N" uniqKey="Clifford M" first="Michael N" last="Clifford">Michael N. Clifford</name>
<affiliation wicri:level="4"><nlm:affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</nlm:affiliation>
<orgName type="university">Université de Glasgow</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Del Rio, Daniele" sort="Del Rio, Daniele" uniqKey="Del Rio D" first="Daniele" last="Del Rio">Daniele Del Rio</name>
<affiliation wicri:level="4"><nlm:affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</nlm:affiliation>
<orgName type="university">Université de Glasgow</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lean, Michael E J" sort="Lean, Michael E J" uniqKey="Lean M" first="Michael E J" last="Lean">Michael E J. Lean</name>
<affiliation wicri:level="4"><nlm:affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</nlm:affiliation>
<orgName type="university">Université de Glasgow</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roberts, Susan A" sort="Roberts, Susan A" uniqKey="Roberts S" first="Susan A" last="Roberts">Susan A. Roberts</name>
<affiliation wicri:level="4"><nlm:affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</nlm:affiliation>
<orgName type="university">Université de Glasgow</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
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<author><name sortKey="Kellerhals, Michele B" sort="Kellerhals, Michele B" uniqKey="Kellerhals M" first="Michele B" last="Kellerhals">Michele B. Kellerhals</name>
<affiliation wicri:level="4"><nlm:affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</nlm:affiliation>
<orgName type="university">Université de Glasgow</orgName>
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<author><name sortKey="Crozier, Alan" sort="Crozier, Alan" uniqKey="Crozier A" first="Alan" last="Crozier">Alan Crozier</name>
<affiliation wicri:level="4"><nlm:affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</nlm:affiliation>
<orgName type="university">Université de Glasgow</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
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<term>Citrus sinensis (chemistry)</term>
<term>Colon (drug effects)</term>
<term>Colon (metabolism)</term>
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<front><div type="abstract" xml:lang="en">We assessed the bioavailability of orange juice (poly)phenols by monitoring urinary flavanone metabolites and ring fission catabolites produced by the action of the colonic microbiota.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25332336</PMID>
<DateCreated><Year>2014</Year>
<Month>10</Month>
<Day>21</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>02</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised><Year>2014</Year>
<Month>10</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1938-3207</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>100</Volume>
<Issue>5</Issue>
<PubDate><Year>2014</Year>
<Month>Nov</Month>
</PubDate>
</JournalIssue>
<Title>The American journal of clinical nutrition</Title>
<ISOAbbreviation>Am. J. Clin. Nutr.</ISOAbbreviation>
</Journal>
<ArticleTitle>Orange juice (poly)phenols are highly bioavailable in humans.</ArticleTitle>
<Pagination><MedlinePgn>1378-84</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3945/ajcn.114.090282</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">We assessed the bioavailability of orange juice (poly)phenols by monitoring urinary flavanone metabolites and ring fission catabolites produced by the action of the colonic microbiota.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Our objective was to identify and quantify metabolites and catabolites excreted in urine 0-24 h after the acute ingestion of a (poly)phenol-rich orange juice by 12 volunteers.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">Twelve volunteers [6 men and 6 women; body mass index (in kg/m(2)): 23.9-37.2] consumed a low (poly)phenol diet for 2 d before first drinking 250 mL pulp-enriched orange juice, which contained 584 μmol (poly)phenols of which 537 μmol were flavanones, and after a 2-wk washout, the procedure was repeated, and a placebo drink was consumed. Urine collected for a 24-h period was analyzed qualitatively and quantitatively by using high-performance liquid chromatography-mass spectrometry (HPLC-MS) and gas chromatography-mass spectrometry (GC-MS).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 14 metabolites were identified and quantified in urine by using HPLC-MS after orange juice intake. Hesperetin-O-glucuronides, naringenin-O-glucuronides, and hesperetin-3'-O-sulfate were the main metabolites. The overall urinary excretion of flavanone metabolites corresponded to 16% of the intake of 584 μmol (poly)phenols. The GC-MS analysis revealed that 8 urinary catabolites were also excreted in significantly higher quantities after orange juice consumption. These catabolites were 3-(3'-methoxy-4'-hydroxyphenyl)propionic acid, 3-(3'-hydroxy-4'-methoxyphenyl)propionic acid, 3-(3'-hydroxy-4'-methoxyphenyl)hydracrylic acid, 3-(3'-hydroxyphenyl)hydracrylic acid, 3'-methoxy-4'-hydroxyphenylacetic acid, hippuric acid, 3'-hydroxyhippuric acid, and 4'-hydroxyhippuric acid. These aromatic acids originated from the colonic microbiota-mediated breakdown of orange juice (poly)phenols and were excreted in amounts equivalent to 88% of (poly)phenol intake. When combined with the 16% excretion of metabolites, this percentage raised the overall urinary excretion to ∼ 100% of intake.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">When colon-derived phenolic catabolites are included with flavanone glucuronide and sulfate metabolites, orange juice (poly)phenols are much-more bioavailable than previously envisaged. In vitro and ex vivo studies on mechanisms underlying the potential protective effects of orange juice consumption should use in vivo metabolites and catabolites detected in this investigation at physiologic concentrations. The trial was registered at BioMed Central Ltd (www.controlledtrials.com) as ISRCTN04271658.</AbstractText>
<CopyrightInformation>© 2014 American Society for Nutrition.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pereira-Caro</LastName>
<ForeName>Gema</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Borges</LastName>
<ForeName>Gina</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van der Hooft</LastName>
<ForeName>Justin</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Clifford</LastName>
<ForeName>Michael N</ForeName>
<Initials>MN</Initials>
<AffiliationInfo><Affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Del Rio</LastName>
<ForeName>Daniele</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lean</LastName>
<ForeName>Michael E J</ForeName>
<Initials>ME</Initials>
<AffiliationInfo><Affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Roberts</LastName>
<ForeName>Susan A</ForeName>
<Initials>SA</Initials>
<AffiliationInfo><Affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kellerhals</LastName>
<ForeName>Michele B</ForeName>
<Initials>MB</Initials>
<AffiliationInfo><Affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Crozier</LastName>
<ForeName>Alan</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>From the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (GP-C, GB, JvdH, and AC); the School of Biosciences and Medicine, Faculty of Health and Medical Sciences, The Dorothy Hodgkins Building, University of Surrey, Guildford, Surrey, United Kingdom (MNC); the Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy (DDR); the School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom (MEJL); the Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA (SAR); and Research and Development, Coca-Cola Services nv, Brussels, Belgium (MBK).</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>ENG</Language>
<DataBankList CompleteYN="Y"><DataBank><DataBankName>ISRCTN</DataBankName>
<AccessionNumberList><AccessionNumber>ISRCTN04271658</AccessionNumber>
</AccessionNumberList>
</DataBank>
</DataBankList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>Aug</Month>
<Day>27</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Am J Clin Nutr</MedlineTA>
<NlmUniqueID>0376027</NlmUniqueID>
<ISSNLinking>0002-9165</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D044950">Flavanones</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D020719">Glucuronides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D059808">Polyphenols</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C587870">hesperetin-7-O-glucuronide</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>487-26-3</RegistryNumber>
<NameOfSubstance UI="C028610">flavanone</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>E750O06Y6O</RegistryNumber>
<NameOfSubstance UI="D006569">Hesperidin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>HN5425SBF2</RegistryNumber>
<NameOfSubstance UI="C005273">naringenin</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001628" MajorTopicYN="N">Beverages</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001682" MajorTopicYN="N">Biological Availability</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015992" MajorTopicYN="N">Body Mass Index</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002851" MajorTopicYN="N">Chromatography, High Pressure Liquid</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D032084" MajorTopicYN="N">Citrus sinensis</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003106" MajorTopicYN="N">Colon</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018592" MajorTopicYN="N">Cross-Over Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D044950" MajorTopicYN="N">Flavanones</DescriptorName>
<QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName>
<QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005638" MajorTopicYN="N">Fruit</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008401" MajorTopicYN="N">Gas Chromatography-Mass Spectrometry</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020719" MajorTopicYN="N">Glucuronides</DescriptorName>
<QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName>
<QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064368" MajorTopicYN="N">Healthy Volunteers</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006569" MajorTopicYN="N">Hesperidin</DescriptorName>
<QualifierName UI="Q000031" MajorTopicYN="N">analogs & derivatives</QualifierName>
<QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName>
<QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057230" MajorTopicYN="N">Limit of Detection</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016014" MajorTopicYN="N">Linear Models</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059808" MajorTopicYN="N">Polyphenols</DescriptorName>
<QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName>
<QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
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<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
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<Month>10</Month>
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<Hour>6</Hour>
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<ArticleIdList><ArticleId IdType="pubmed">25332336</ArticleId>
<ArticleId IdType="pii">ajcn.114.090282</ArticleId>
<ArticleId IdType="doi">10.3945/ajcn.114.090282</ArticleId>
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<affiliations><list><country><li>Royaume-Uni</li>
</country>
<region><li>Écosse</li>
</region>
<settlement><li>Glasgow</li>
</settlement>
<orgName><li>Université de Glasgow</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Pereira Caro, Gema" sort="Pereira Caro, Gema" uniqKey="Pereira Caro G" first="Gema" last="Pereira-Caro">Gema Pereira-Caro</name>
</region>
<name sortKey="Borges, Gina" sort="Borges, Gina" uniqKey="Borges G" first="Gina" last="Borges">Gina Borges</name>
<name sortKey="Clifford, Michael N" sort="Clifford, Michael N" uniqKey="Clifford M" first="Michael N" last="Clifford">Michael N. Clifford</name>
<name sortKey="Crozier, Alan" sort="Crozier, Alan" uniqKey="Crozier A" first="Alan" last="Crozier">Alan Crozier</name>
<name sortKey="Del Rio, Daniele" sort="Del Rio, Daniele" uniqKey="Del Rio D" first="Daniele" last="Del Rio">Daniele Del Rio</name>
<name sortKey="Kellerhals, Michele B" sort="Kellerhals, Michele B" uniqKey="Kellerhals M" first="Michele B" last="Kellerhals">Michele B. Kellerhals</name>
<name sortKey="Lean, Michael E J" sort="Lean, Michael E J" uniqKey="Lean M" first="Michael E J" last="Lean">Michael E J. Lean</name>
<name sortKey="Roberts, Susan A" sort="Roberts, Susan A" uniqKey="Roberts S" first="Susan A" last="Roberts">Susan A. Roberts</name>
<name sortKey="Van Der Hooft, Justin" sort="Van Der Hooft, Justin" uniqKey="Van Der Hooft J" first="Justin" last="Van Der Hooft">Justin Van Der Hooft</name>
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