A Review of the Receptor-Binding Properties of p-Synephrine as Related to Its Pharmacological Effects
Identifieur interne : 000E14 ( Ncbi/Merge ); précédent : 000E13; suivant : 000E15A Review of the Receptor-Binding Properties of p-Synephrine as Related to Its Pharmacological Effects
Auteurs : Sidney J. Stohs [États-Unis] ; Harry G. Preuss [États-Unis] ; Mohd Shara [Jordanie]Source :
- Oxidative Medicine and Cellular Longevity [ 1942-0900 ] ; 2011.
Abstract
Bitter orange (
Url:
DOI: 10.1155/2011/482973
PubMed: 21904645
PubMed Central: 3166186
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Review of the Receptor-Binding Properties of <italic>p</italic>-Synephrine as Related to Its Pharmacological Effects</title><author><name sortKey="Stohs, Sidney J" sort="Stohs, Sidney J" uniqKey="Stohs S" first="Sidney J." last="Stohs">Sidney J. Stohs</name><affiliation wicri:level="1"><nlm:aff id="I1">School of Pharmacy and Health Professions, Creighton University Medical Center, Omaha, NE 68178, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Pharmacy and Health Professions, Creighton University Medical Center, Omaha, NE 68178</wicri:regionArea><wicri:noRegion>NE 68178</wicri:noRegion></affiliation></author><author><name sortKey="Preuss, Harry G" sort="Preuss, Harry G" uniqKey="Preuss H" first="Harry G." last="Preuss">Harry G. Preuss</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Medicine and Pathology, Georgetown University Medical Center, Washington, DC 22039, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Pathology, Georgetown University Medical Center, Washington, DC 22039</wicri:regionArea><wicri:noRegion>DC 22039</wicri:noRegion></affiliation></author><author><name sortKey="Shara, Mohd" sort="Shara, Mohd" uniqKey="Shara M" first="Mohd" last="Shara">Mohd Shara</name><affiliation wicri:level="1"><nlm:aff id="I3">Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan</nlm:aff><country xml:lang="fr">Jordanie</country><wicri:regionArea>Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110</wicri:regionArea><wicri:noRegion>Irbid 22110</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21904645</idno><idno type="pmc">3166186</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166186</idno><idno type="RBID">PMC:3166186</idno><idno type="doi">10.1155/2011/482973</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001400</idno><idno type="wicri:Area/Pmc/Curation">001398</idno><idno type="wicri:Area/Pmc/Checkpoint">000E99</idno><idno type="wicri:Area/Ncbi/Merge">000E14</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Review of the Receptor-Binding Properties of <italic>p</italic>-Synephrine as Related to Its Pharmacological Effects</title><author><name sortKey="Stohs, Sidney J" sort="Stohs, Sidney J" uniqKey="Stohs S" first="Sidney J." last="Stohs">Sidney J. Stohs</name><affiliation wicri:level="1"><nlm:aff id="I1">School of Pharmacy and Health Professions, Creighton University Medical Center, Omaha, NE 68178, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Pharmacy and Health Professions, Creighton University Medical Center, Omaha, NE 68178</wicri:regionArea><wicri:noRegion>NE 68178</wicri:noRegion></affiliation></author><author><name sortKey="Preuss, Harry G" sort="Preuss, Harry G" uniqKey="Preuss H" first="Harry G." last="Preuss">Harry G. Preuss</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Medicine and Pathology, Georgetown University Medical Center, Washington, DC 22039, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Pathology, Georgetown University Medical Center, Washington, DC 22039</wicri:regionArea><wicri:noRegion>DC 22039</wicri:noRegion></affiliation></author><author><name sortKey="Shara, Mohd" sort="Shara, Mohd" uniqKey="Shara M" first="Mohd" last="Shara">Mohd Shara</name><affiliation wicri:level="1"><nlm:aff id="I3">Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan</nlm:aff><country xml:lang="fr">Jordanie</country><wicri:regionArea>Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110</wicri:regionArea><wicri:noRegion>Irbid 22110</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oxidative Medicine and Cellular Longevity</title><idno type="ISSN">1942-0900</idno><idno type="eISSN">1942-0994</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Bitter orange (<italic>Citrus aurantium</italic>) extract and its primary protoalkaloid <italic>p</italic>-synephrine are used widely in weight loss/weight management and sports performance products. Because of structural similarities, the pharmacological effects of <italic>p</italic>-synephrine are widely assumed to be similar to those of ephedrine, <italic>m</italic>-synephrine (phenylephrine), and endogenous amine neurotransmitters as norepinephrine and epinephrine. However, small structural changes result in the receptor binding characteristics of these amines that are markedly different, providing a plausible explanation for the paucity of adverse effects associated with the wide-spread consumption of <italic>p</italic>-synephrine in the form of dietary supplements as well as in various <italic>Citrus</italic> foods and juices. This paper summarizes the adrenoreceptor binding characteristics of <italic>p</italic>-synephrine relative to <italic>m</italic>-synephrine, norepinephrine, and other amines as related to the observed pharmacological effects.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Pellati, F" uniqKey="Pellati F">F Pellati</name></author><author><name sortKey="Benvenuti, S" uniqKey="Benvenuti S">S Benvenuti</name></author><author><name sortKey="Melegari, M" uniqKey="Melegari M">M Melegari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pellati, F" uniqKey="Pellati F">F Pellati</name></author><author><name sortKey="Benvenuti, S" uniqKey="Benvenuti S">S Benvenuti</name></author><author><name sortKey="Melegari, M" uniqKey="Melegari M">M Melegari</name></author><author><name sortKey="Firenzuoli, F" uniqKey="Firenzuoli F">F Firenzuoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pellati, F" uniqKey="Pellati F">F Pellati</name></author><author><name sortKey="Benvenuti, S" uniqKey="Benvenuti S">S Benvenuti</name></author><author><name sortKey="Melegari, M" uniqKey="Melegari M">M Melegari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Avula, B" uniqKey="Avula B">B Avula</name></author><author><name sortKey="Upparapalli, Sk" uniqKey="Upparapalli S">SK Upparapalli</name></author><author><name sortKey="Navarrete, A" uniqKey="Navarrete A">A Navarrete</name></author><author><name sortKey="Khan, Ia" uniqKey="Khan I">IA Khan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arbo, Md" uniqKey="Arbo M">MD Arbo</name></author><author><name sortKey="Larentis, Er" uniqKey="Larentis E">ER Larentis</name></author><author><name sortKey="Linck, Vm" uniqKey="Linck V">VM Linck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mattoli, L" uniqKey="Mattoli L">L Mattoli</name></author><author><name sortKey="Cangi, F" uniqKey="Cangi F">F Cangi</name></author><author><name sortKey="Maidecchi, A" uniqKey="Maidecchi A">A Maidecchi</name></author><author><name sortKey="Ghiara, C" uniqKey="Ghiara C">C Ghiara</name></author><author><name sortKey="Stubaro, M" uniqKey="Stubaro M">M Stubaro</name></author><author><name sortKey="Tralda, Pa" uniqKey="Tralda P">PA Tralda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsujita, T" uniqKey="Tsujita T">T Tsujita</name></author><author><name sortKey="Takaku, T" uniqKey="Takaku T">T Takaku</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mercolini, L" uniqKey="Mercolini L">L Mercolini</name></author><author><name sortKey="Mandrioli, R" uniqKey="Mandrioli R">R Mandrioli</name></author><author><name sortKey="Trere, T" uniqKey="Trere T">T Trerè</name></author><author><name sortKey="Bugamelli, F" uniqKey="Bugamelli F">F Bugamelli</name></author><author><name sortKey="Ferranti, A" uniqKey="Ferranti A">A Ferranti</name></author><author><name sortKey="Raggi, Ma" uniqKey="Raggi M">MA Raggi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roman, Mc" uniqKey="Roman M">MC Roman</name></author><author><name sortKey="Betz, Jm" uniqKey="Betz J">JM Betz</name></author><author><name sortKey="Hildreth, J" uniqKey="Hildreth J">J Hildreth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossato, Lg" uniqKey="Rossato L">LG Rossato</name></author><author><name sortKey="De Pinho, Pg" uniqKey="De Pinho P">PG de Pinho</name></author><author><name sortKey="Silva, R" uniqKey="Silva R">R Silva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Percy, Dw" uniqKey="Percy D">DW Percy</name></author><author><name sortKey="Adcock, Jl" uniqKey="Adcock J">JL Adcock</name></author><author><name sortKey="Conlan, Xa" uniqKey="Conlan X">XA Conlan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nelson, Bc" uniqKey="Nelson B">BC Nelson</name></author><author><name sortKey="Putzbach, K" uniqKey="Putzbach K">K Putzbach</name></author><author><name sortKey="Sharpless, Ke" uniqKey="Sharpless K">KE Sharpless</name></author><author><name sortKey="Sander, Lc" uniqKey="Sander L">LC Sander</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sander, Lc" uniqKey="Sander L">LC Sander</name></author><author><name sortKey="Putzbach, K" uniqKey="Putzbach K">K Putzbach</name></author><author><name sortKey="Nelson, Bc" uniqKey="Nelson B">BC Nelson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dragull, K" uniqKey="Dragull K">K Dragull</name></author><author><name sortKey="Breksa, Ap" uniqKey="Breksa A">AP Breksa</name></author><author><name sortKey="Cain, B" uniqKey="Cain B">B Cain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uckoo, Rm" uniqKey="Uckoo R">RM Uckoo</name></author><author><name sortKey="Jayaprakasha, Gk" uniqKey="Jayaprakasha G">GK Jayaprakasha</name></author><author><name sortKey="Nelson, Sd" uniqKey="Nelson S">SD Nelson</name></author><author><name sortKey="Patil, Bs" uniqKey="Patil B">BS Patil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcguffin, M" uniqKey="Mcguffin M">M McGuffin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stohs, Sj" uniqKey="Stohs S">SJ Stohs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stohs, Sj" uniqKey="Stohs S">SJ Stohs</name></author><author><name sortKey="Preuss, Hg" uniqKey="Preuss H">HG Preuss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bent, S" uniqKey="Bent S">S Bent</name></author><author><name sortKey="Padula, A" uniqKey="Padula A">A Padula</name></author><author><name sortKey="Neuhaus, J" uniqKey="Neuhaus J">J Neuhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Penzak, Sr" uniqKey="Penzak S">SR Penzak</name></author><author><name sortKey="Jann, Mw" uniqKey="Jann M">MW Jann</name></author><author><name sortKey="Cold, Ja" uniqKey="Cold J">JA Cold</name></author><author><name sortKey="Hori, Yy" uniqKey="Hori Y">YY Hori</name></author><author><name sortKey="Desai, Hd" uniqKey="Desai H">HD Desai</name></author><author><name sortKey="Gurley, Bj" uniqKey="Gurley B">BJ Gurley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fugh Berman, A" uniqKey="Fugh Berman A">A Fugh-Berman</name></author><author><name sortKey="Myers, A" uniqKey="Myers A">A Myers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haaz, S" uniqKey="Haaz S">S Haaz</name></author><author><name sortKey="Williams, Ky" uniqKey="Williams K">KY Williams</name></author><author><name sortKey="Fontaine, Kr" uniqKey="Fontaine K">KR Fontaine</name></author><author><name sortKey="Allison, Dr" uniqKey="Allison D">DR Allison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossato, Lg" uniqKey="Rossato L">LG Rossato</name></author><author><name sortKey="Costa, Vm" uniqKey="Costa V">VM Costa</name></author><author><name sortKey="Limberger, Rp" uniqKey="Limberger R">RP Limberger</name></author><author><name sortKey="Bastos, Mdl" uniqKey="Bastos M">MDL Bastos</name></author><author><name sortKey="Remiao, F" uniqKey="Remiao F">F Remião</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Inchiosa, Ma" uniqKey="Inchiosa M">MA Inchiosa</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Pellati, F" uniqKey="Pellati F">F Pellati</name></author><author><name sortKey="Benvenuti, S" uniqKey="Benvenuti S">S Benvenuti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, D" uniqKey="Jones D">D Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jordan, R" uniqKey="Jordan R">R Jordan</name></author><author><name sortKey="Thonoor, Cm" uniqKey="Thonoor C">CM Thonoor</name></author><author><name sortKey="Williams, Cm" uniqKey="Williams C">CM Williams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, G" uniqKey="Ma G">G Ma</name></author><author><name sortKey="Bavadekar, Sa" uniqKey="Bavadekar S">SA Bavadekar</name></author><author><name sortKey="Schaneberg, Bt" uniqKey="Schaneberg B">BT Schaneberg</name></author><author><name sortKey="Khan, Ia" uniqKey="Khan I">IA Khan</name></author><author><name sortKey="Feller, Dr" uniqKey="Feller D">DR Feller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, Cm" uniqKey="Brown C">CM Brown</name></author><author><name sortKey="Mcgrath, Jc" uniqKey="Mcgrath J">JC McGrath</name></author><author><name sortKey="Midgley, Jm" uniqKey="Midgley J">JM Midgley</name></author><author><name sortKey="Muir, Ag" uniqKey="Muir A">AG Muir</name></author><author><name sortKey="O Rien, Jw" uniqKey="O Rien J">JW O’Brien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hwa, J" uniqKey="Hwa J">J Hwa</name></author><author><name sortKey="Perez, Dm" uniqKey="Perez D">DM Perez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hibino, T" uniqKey="Hibino T">T Hibino</name></author><author><name sortKey="Yuzurihara, M" uniqKey="Yuzurihara M">M Yuzurihara</name></author><author><name sortKey="Kase, Y" uniqKey="Kase Y">Y Kase</name></author><author><name sortKey="Takeda, A" uniqKey="Takeda A">A Takeda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haller, Ca" uniqKey="Haller C">CA Haller</name></author><author><name sortKey="Benowitz, Nl" uniqKey="Benowitz N">NL Benowitz</name></author><author><name sortKey="Jacob, P" uniqKey="Jacob P">P Jacob</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossato, Lg" uniqKey="Rossato L">LG Rossato</name></author><author><name sortKey="Costa, Vm" uniqKey="Costa V">VM Costa</name></author><author><name sortKey="Depinho, Pg" uniqKey="Depinho P">PG dePinho</name></author><author><name sortKey="Caryalho, F" uniqKey="Caryalho F">F Caryalho</name></author><author><name sortKey="Delourdes, Bm" uniqKey="Delourdes B">BM deLourdes</name></author><author><name sortKey="Remiao, F" uniqKey="Remiao F">F Remiao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arch, Jrs" uniqKey="Arch J">JRS Arch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alemzadeh, R" uniqKey="Alemzadeh R">R Alemzadeh</name></author><author><name sortKey="Karlstad, Md" uniqKey="Karlstad M">MD Karlstad</name></author><author><name sortKey="Tushaus, K" uniqKey="Tushaus K">K Tushaus</name></author><author><name sortKey="Buchholz, M" uniqKey="Buchholz M">M Buchholz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oana, F" uniqKey="Oana F">F Oana</name></author><author><name sortKey="Homma, T" uniqKey="Homma T">T Homma</name></author><author><name sortKey="Takeda, H" uniqKey="Takeda H">H Takeda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamilton, Bs" uniqKey="Hamilton B">BS Hamilton</name></author><author><name sortKey="Doods, Hn" uniqKey="Doods H">HN Doods</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Canova, Nk" uniqKey="Canova N">NK Canova</name></author><author><name sortKey="Lincova, D" uniqKey="Lincova D">D Lincova</name></author><author><name sortKey="Kmonickova, E" uniqKey="Kmonickova E">E Kmonickova</name></author><author><name sortKey="Farghili, H" uniqKey="Farghili H">H Farghili</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dulloo, Ag" uniqKey="Dulloo A">AG Dulloo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carpene, C" uniqKey="Carpene C">C Carpene</name></author><author><name sortKey="Galitzky, J" uniqKey="Galitzky J">J Galitzky</name></author><author><name sortKey="Fontana, E" uniqKey="Fontana E">E Fontana</name></author><author><name sortKey="Algie, C" uniqKey="Algie C">C Algie</name></author><author><name sortKey="Lafontan, M" uniqKey="Lafontan M">M Lafontan</name></author><author><name sortKey="Berlan, E" uniqKey="Berlan E">E Berlan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsujita, T" uniqKey="Tsujita T">T Tsujita</name></author><author><name sortKey="Takaku, T" uniqKey="Takaku T">T Takaku</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parmar, Hs" uniqKey="Parmar H">HS Parmar</name></author><author><name sortKey="Kar, A" uniqKey="Kar A">A Kar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parmar, Hs" uniqKey="Parmar H">HS Parmar</name></author><author><name sortKey="Kar, A" uniqKey="Kar A">A Kar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shannon, Jr" uniqKey="Shannon J">JR Shannon</name></author><author><name sortKey="Gottesdiener, K" uniqKey="Gottesdiener K">K Gottesdiener</name></author><author><name sortKey="Jordan, J" uniqKey="Jordan J">J Jordan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arbo, Md" uniqKey="Arbo M">MD Arbo</name></author><author><name sortKey="Schmitt, Gc" uniqKey="Schmitt G">GC Schmitt</name></author><author><name sortKey="Limberger, Mf" uniqKey="Limberger M">MF Limberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pandey, Kb" uniqKey="Pandey K">KB Pandey</name></author><author><name sortKey="Rizvi, Si" uniqKey="Rizvi S">SI Rizvi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bouayed, J" uniqKey="Bouayed J">J Bouayed</name></author><author><name sortKey="Bohn, T" uniqKey="Bohn T">T Bohn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hansen, Dk" uniqKey="Hansen D">DK Hansen</name></author><author><name sortKey="Julier, Be" uniqKey="Julier B">BE Julier</name></author><author><name sortKey="White, Ge" uniqKey="White G">GE White</name></author><author><name sortKey="Pellicore, Ls" uniqKey="Pellicore L">LS Pellicore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mercader, J" uniqKey="Mercader J">J Mercader</name></author><author><name sortKey="Wanecq, E" uniqKey="Wanecq E">E Wanecq</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Carpene, C" uniqKey="Carpene C">C Carpene</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rozec, B" uniqKey="Rozec B">B Rozec</name></author><author><name sortKey="Gauther, C" uniqKey="Gauther C">C Gauther</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moens, Al" uniqKey="Moens A">AL Moens</name></author><author><name sortKey="Yang, R" uniqKey="Yang R">R Yang</name></author><author><name sortKey="Watts, Vl" uniqKey="Watts V">VL Watts</name></author><author><name sortKey="Barouch, La" uniqKey="Barouch L">LA Barouch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riksen, Np" uniqKey="Riksen N">NP Riksen</name></author><author><name sortKey="Smits, P" uniqKey="Smits P">P Smits</name></author><author><name sortKey="Rongen, Ga" uniqKey="Rongen G">GA Rongen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, A" uniqKey="Yang A">A Yang</name></author><author><name sortKey="Palmer, Aa" uniqKey="Palmer A">AA Palmer</name></author><author><name sortKey="Dewit, H" uniqKey="Dewit H">H DeWit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lind, U" uniqKey="Lind U">U Lind</name></author><author><name sortKey="Alm, Rm" uniqKey="Alm R">RM Alm</name></author><author><name sortKey="Hasselberg, Fl" uniqKey="Hasselberg F">FL Hasselberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farooqui, T" uniqKey="Farooqui T">T Farooqui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Evans, Pd" uniqKey="Evans P">PD Evans</name></author><author><name sortKey="Maqueira, B" uniqKey="Maqueira B">B Maqueira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blais, V" uniqKey="Blais V">V Blais</name></author><author><name sortKey="Bounif, N" uniqKey="Bounif N">N Bounif</name></author><author><name sortKey="Dube, F" uniqKey="Dube F">F Dubé</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rillich, J" uniqKey="Rillich J">J Rillich</name></author><author><name sortKey="Schildberger, K" uniqKey="Schildberger K">K Schildberger</name></author><author><name sortKey="Stevenson, Pa" uniqKey="Stevenson P">PA Stevenson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Evans, Pd" uniqKey="Evans P">PD Evans</name></author><author><name sortKey="Thonoor, Cm" uniqKey="Thonoor C">CM Thonoor</name></author><author><name sortKey="Midgley, Jm" uniqKey="Midgley J">JM Midgley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Jh" uniqKey="Park J">JH Park</name></author><author><name sortKey="Keeley, Ll" uniqKey="Keeley L">LL Keeley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klaassen, Lw" uniqKey="Klaassen L">LW Klaassen</name></author><author><name sortKey="Kammer, Ae" uniqKey="Kammer A">AE Kammer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colker, Cm" uniqKey="Colker C">CM Colker</name></author><author><name sortKey="Kalman, Ds" uniqKey="Kalman D">DS Kalman</name></author><author><name sortKey="Torina, Gc" uniqKey="Torina G">GC Torina</name></author><author><name sortKey="Perlis, T" uniqKey="Perlis T">T Perlis</name></author><author><name sortKey="Street, C" uniqKey="Street C">C Street</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Min, B" uniqKey="Min B">B Min</name></author><author><name sortKey="Cios, D" uniqKey="Cios D">D Cios</name></author><author><name sortKey="Kluger, J" uniqKey="Kluger J">J Kluger</name></author><author><name sortKey="White, Cm" uniqKey="White C">CM White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sale, C" uniqKey="Sale C">C Sale</name></author><author><name sortKey="Harris, Rc" uniqKey="Harris R">RC Harris</name></author><author><name sortKey="Delves, S" uniqKey="Delves S">S Delves</name></author><author><name sortKey="Corbett, J" uniqKey="Corbett J">J Corbett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gougeon, R" uniqKey="Gougeon R">R Gougeon</name></author><author><name sortKey="Harrigan, K" uniqKey="Harrigan K">K Harrigan</name></author><author><name sortKey="Tremblay, Jf" uniqKey="Tremblay J">JF Tremblay</name></author><author><name sortKey="Hedrei, P" uniqKey="Hedrei P">P Hedrei</name></author><author><name sortKey="Lamarche, M" uniqKey="Lamarche M">M Lamarche</name></author><author><name sortKey="Morais, Ja" uniqKey="Morais J">JA Morais</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zenk, Jl" uniqKey="Zenk J">JL Zenk</name></author><author><name sortKey="Leikam, Sa" uniqKey="Leikam S">SA Leikam</name></author><author><name sortKey="Kassen, Lj" uniqKey="Kassen L">LJ Kassen</name></author><author><name sortKey="Kuskowski, Ma" uniqKey="Kuskowski M">MA Kuskowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoffman, Jr" uniqKey="Hoffman J">JR Hoffman</name></author><author><name sortKey="Kang, J" uniqKey="Kang J">J Kang</name></author><author><name sortKey="Ratamess, A" uniqKey="Ratamess A">A Ratamess</name></author><author><name sortKey="Jennings, Pf" uniqKey="Jennings P">PF Jennings</name></author><author><name sortKey="Mangione, G" uniqKey="Mangione G">G Mangione</name></author><author><name sortKey="Faigenbaum, Ad" uniqKey="Faigenbaum A">AD Faigenbaum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stohs, Sj" uniqKey="Stohs S">SJ Stohs</name></author><author><name sortKey="Preuss, Hg" uniqKey="Preuss H">HG Preuss</name></author><author><name sortKey="Keith, Sc" uniqKey="Keith S">SC Keith</name></author><author><name sortKey="Keith, Pl" uniqKey="Keith P">PL Keith</name></author><author><name sortKey="Miller, H" uniqKey="Miller H">H Miller</name></author><author><name sortKey="Kaats, Gr" uniqKey="Kaats G">GR Kaats</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seifert, Jg" uniqKey="Seifert J">JG Seifert</name></author><author><name sortKey="Nelson, A" uniqKey="Nelson A">A Nelson</name></author><author><name sortKey="Devonish, J" uniqKey="Devonish J">J Devonish</name></author><author><name sortKey="Burke, Er" uniqKey="Burke E">ER Burke</name></author><author><name sortKey="Stohs, Sj" uniqKey="Stohs S">SJ Stohs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haller, Ca" uniqKey="Haller C">CA Haller</name></author><author><name sortKey="Duan, M" uniqKey="Duan M">M Duan</name></author><author><name sortKey="Peyton, J" uniqKey="Peyton J">J Peyton</name></author><author><name sortKey="Benowitz, N" uniqKey="Benowitz N">N Benowitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smedema, Jp" uniqKey="Smedema J">JP Smedema</name></author><author><name sortKey="Muller, Gj" uniqKey="Muller G">GJ Müller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stephensen, Ta" uniqKey="Stephensen T">TA Stephensen</name></author><author><name sortKey="Sarlay, R" uniqKey="Sarlay R">R Sarlay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clauson, K" uniqKey="Clauson K">K Clauson</name></author><author><name sortKey="Shields, Km" uniqKey="Shields K">KM Shields</name></author><author><name sortKey="Mcquee, Ce" uniqKey="Mcquee C">CE McQuee</name></author><author><name sortKey="Persad, N" uniqKey="Persad N">N Persad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Calapai, G" uniqKey="Calapai G">G Calapai</name></author><author><name sortKey="Firenzuoli, F" uniqKey="Firenzuoli F">F Firenzuoli</name></author><author><name sortKey="Saitta, A" uniqKey="Saitta A">A Saitta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Titta, L" uniqKey="Titta L">L Titta</name></author><author><name sortKey="Trinei, M" uniqKey="Trinei M">M Trinei</name></author><author><name sortKey="Stendardo, M" uniqKey="Stendardo M">M Stendardo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Yt" uniqKey="Huang Y">YT Huang</name></author><author><name sortKey="Lin, Hc" uniqKey="Lin H">HC Lin</name></author><author><name sortKey="Chang, Yy" uniqKey="Chang Y">YY Chang</name></author><author><name sortKey="Yang, Yy" uniqKey="Yang Y">YY Yang</name></author><author><name sortKey="Lee, Sd" uniqKey="Lee S">SD Lee</name></author><author><name sortKey="Hong, Cy" uniqKey="Hong C">CY Hong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bui, Lt" uniqKey="Bui L">LT Bui</name></author><author><name sortKey="Nguyen, Dt" uniqKey="Nguyen D">DT Nguyen</name></author><author><name sortKey="Ambrose, Pj" uniqKey="Ambrose P">PJ Ambrose</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hengstmann, Jh" uniqKey="Hengstmann J">JH Hengstmann</name></author><author><name sortKey="Aulepp, H" uniqKey="Aulepp H">H Aulepp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oben, J" uniqKey="Oben J">J Oben</name></author><author><name sortKey="Enonchong, E" uniqKey="Enonchong E">E Enonchong</name></author><author><name sortKey="Kothari, S" uniqKey="Kothari S">S Kothari</name></author><author><name sortKey="Chambliss, W" uniqKey="Chambliss W">W Chambliss</name></author><author><name sortKey="Garrison, R" uniqKey="Garrison R">R Garrison</name></author><author><name sortKey="Dolnick, D" uniqKey="Dolnick D">D Dolnick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stohs, Sj" uniqKey="Stohs S">SJ Stohs</name></author><author><name sortKey="Shara, M" uniqKey="Shara M">M Shara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stohs, Sj" uniqKey="Stohs S">SJ Stohs</name></author><author><name sortKey="Shara, M" uniqKey="Shara M">M Shara</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Oxid Med Cell Longev</journal-id><journal-id journal-id-type="publisher-id">OXIMED</journal-id><journal-title-group><journal-title>Oxidative Medicine and Cellular Longevity</journal-title></journal-title-group><issn pub-type="ppub">1942-0900</issn><issn pub-type="epub">1942-0994</issn><publisher><publisher-name>Hindawi Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21904645</article-id><article-id pub-id-type="pmc">3166186</article-id><article-id pub-id-type="doi">10.1155/2011/482973</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title>A Review of the Receptor-Binding Properties of <italic>p</italic>-Synephrine as Related to Its Pharmacological Effects</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Stohs</surname><given-names>Sidney J.</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Preuss</surname><given-names>Harry G.</given-names></name><xref ref-type="aff" rid="I2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shara</surname><given-names>Mohd</given-names></name><xref ref-type="aff" rid="I3"><sup>3</sup></xref></contrib></contrib-group><aff id="I1"><sup>1</sup>School of Pharmacy and Health Professions, Creighton University Medical Center, Omaha, NE 68178, USA</aff><aff id="I2"><sup>2</sup>Department of Medicine and Pathology, Georgetown University Medical Center, Washington, DC 22039, USA</aff><aff id="I3"><sup>3</sup>Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan</aff><author-notes><corresp id="cor1">*Sidney J. Stohs: <email>sstohs@yahoo.com</email></corresp><fn fn-type="other"><p>Academic Editor: Neelam Khaper</p></fn></author-notes><pub-date pub-type="ppub"><year>2011</year></pub-date><pub-date pub-type="epub"><day>1</day><month>8</month><year>2011</year></pub-date><volume>2011</volume><elocation-id>482973</elocation-id><history><date date-type="received"><day>18</day><month>1</month><year>2011</year></date><date date-type="accepted"><day>7</day><month>6</month><year>2011</year></date></history><permissions><copyright-statement>Copyright © 2011 Sidney J. Stohs et al.</copyright-statement><copyright-year>2011</copyright-year><license license-type="open-access"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Bitter orange (<italic>Citrus aurantium</italic>) extract and its primary protoalkaloid <italic>p</italic>-synephrine are used widely in weight loss/weight management and sports performance products. Because of structural similarities, the pharmacological effects of <italic>p</italic>-synephrine are widely assumed to be similar to those of ephedrine, <italic>m</italic>-synephrine (phenylephrine), and endogenous amine neurotransmitters as norepinephrine and epinephrine. However, small structural changes result in the receptor binding characteristics of these amines that are markedly different, providing a plausible explanation for the paucity of adverse effects associated with the wide-spread consumption of <italic>p</italic>-synephrine in the form of dietary supplements as well as in various <italic>Citrus</italic> foods and juices. This paper summarizes the adrenoreceptor binding characteristics of <italic>p</italic>-synephrine relative to <italic>m</italic>-synephrine, norepinephrine, and other amines as related to the observed pharmacological effects.</p></abstract></article-meta></front><floats-group><fig id="fig1" position="float"><label>Figure 1</label><caption><p><italic>p</italic>-Synephrine.</p></caption><graphic xlink:href="OXIMED2011-482973.001"></graphic></fig><fig id="fig2" position="float"><label>Figure 2</label><caption><p>Ephedrine.</p></caption><graphic xlink:href="OXIMED2011-482973.002"></graphic></fig><fig id="fig3" position="float"><label>Figure 3</label><caption><p><italic>m</italic>-Synephrine.</p></caption><graphic xlink:href="OXIMED2011-482973.003"></graphic></fig><fig id="fig4" position="float"><label>Figure 4</label><caption><p>Phenylpropanolamine.</p></caption><graphic xlink:href="OXIMED2011-482973.004"></graphic></fig><fig id="fig5" position="float"><label>Figure 5</label><caption><p>Nor-epinephrine (Nor-adrenaline).</p></caption><graphic xlink:href="OXIMED2011-482973.005"></graphic></fig><fig id="fig6" position="float"><label>Figure 6</label><caption><p>Epinephrine (Adrenaline).</p></caption><graphic xlink:href="OXIMED2011-482973.006"></graphic></fig><fig id="fig7" position="float"><label>Figure 7</label><caption><p>Amphetamine.</p></caption><graphic xlink:href="OXIMED2011-482973.007"></graphic></fig><fig id="fig8" position="float"><label>Figure 8</label><caption><p><italic>p</italic>-Octopamine.</p></caption><graphic xlink:href="OXIMED2011-482973.008"></graphic></fig></floats-group></pmc><affiliations><list><country><li>Jordanie</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Stohs, Sidney J" sort="Stohs, Sidney J" uniqKey="Stohs S" first="Sidney J." last="Stohs">Sidney J. Stohs</name></noRegion><name sortKey="Preuss, Harry G" sort="Preuss, Harry G" uniqKey="Preuss H" first="Harry G." last="Preuss">Harry G. Preuss</name></country><country name="Jordanie"><noRegion><name sortKey="Shara, Mohd" sort="Shara, Mohd" uniqKey="Shara M" first="Mohd" last="Shara">Mohd Shara</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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