Tangeretin reduces ultraviolet B (UVB)-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking mitogen-activated protein kinase (MAPK) activation and reactive oxygen species (ROS) generation.
Identifieur interne : 000C72 ( Ncbi/Merge ); précédent : 000C71; suivant : 000C73Tangeretin reduces ultraviolet B (UVB)-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking mitogen-activated protein kinase (MAPK) activation and reactive oxygen species (ROS) generation.
Auteurs : Ji Hye Yoon [Corée du Sud] ; Tae-Gyu Lim ; Kyung Mi Lee ; Ae Ji Jeon ; Su Yeon Kim ; Ki Won LeeSource :
- Journal of agricultural and food chemistry [ 1520-5118 ] ; 2011.
English descriptors
- KwdEn :
- Animals, Cells, Cultured, Citrus sinensis (chemistry), Cyclooxygenase 2 (genetics), Cyclooxygenase 2 (metabolism), Down-Regulation, Enzyme Activation (drug effects), Enzyme Activation (radiation effects), Epidermis (drug effects), Epidermis (enzymology), Epidermis (metabolism), Epidermis (radiation effects), Flavones (pharmacology), Gene Expression Regulation, Enzymologic (drug effects), Gene Expression Regulation, Enzymologic (radiation effects), Mice, Mitogen-Activated Protein Kinases (genetics), Mitogen-Activated Protein Kinases (metabolism), Plant Extracts (pharmacology), Reactive Oxygen Species (metabolism), Signal Transduction (drug effects), Ultraviolet Rays.
- MESH :
- chemical , genetics : Cyclooxygenase 2, Mitogen-Activated Protein Kinases.
- chemistry : Citrus sinensis.
- drug effects : Enzyme Activation, Epidermis, Gene Expression Regulation, Enzymologic, Signal Transduction.
- enzymology : Epidermis.
- chemical , metabolism : Cyclooxygenase 2, Epidermis, Mitogen-Activated Protein Kinases, Reactive Oxygen Species.
- chemical , pharmacology : Flavones, Plant Extracts.
- radiation effects : Enzyme Activation, Epidermis, Gene Expression Regulation, Enzymologic.
- Animals, Cells, Cultured, Down-Regulation, Mice, Ultraviolet Rays.
Abstract
The present study examined the effects of tangeretin, a polymethoxylated flavonone present in citrus fruits, on ultraviolet B (UVB)-induced cyclooxygenase-2 (COX-2) expression in JB6 P+ mouse skin epidermal cells. Tangeretin suppressed UVB-induced COX-2 expression and transactivation of nuclear factor-κB and activator protein-1 in JB6 P+ cells. Moreover, tangeretin blocked UVB-induced phosphorylation of Akt and mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated protein kinase, c-Jun N-terminal kinase, and p38, and attenuated the phosphorylation of MAPK kinases 1/2, 3/6, and 4. Tangeretin also limited the endogenous generation of reactive oxygen species (ROS), thereby protecting the cells against oxidative stress. However, tangeretin did not scavenge the stable 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and influence the nicotinamide adenine dinucleotide phosphate oxidase activity. These results suggest that the anti-inflammatory effects of tangeretin stem from its modulation of cell signaling and suppression of intracellular ROS generation. Tangeretin may have a potent chemopreventive effect in skin cancer.
DOI: 10.1021/jf103204x
PubMed: 21126077
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Tangeretin reduces ultraviolet B (UVB)-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking mitogen-activated protein kinase (MAPK) activation and reactive oxygen species (ROS) generation.</title><author><name sortKey="Yoon, Ji Hye" sort="Yoon, Ji Hye" uniqKey="Yoon J" first="Ji Hye" last="Yoon">Ji Hye Yoon</name><affiliation wicri:level="3"><nlm:affiliation>Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lim, Tae Gyu" sort="Lim, Tae Gyu" uniqKey="Lim T" first="Tae-Gyu" last="Lim">Tae-Gyu Lim</name></author><author><name sortKey="Lee, Kyung Mi" sort="Lee, Kyung Mi" uniqKey="Lee K" first="Kyung Mi" last="Lee">Kyung Mi Lee</name></author><author><name sortKey="Jeon, Ae Ji" sort="Jeon, Ae Ji" uniqKey="Jeon A" first="Ae Ji" last="Jeon">Ae Ji Jeon</name></author><author><name sortKey="Kim, Su Yeon" sort="Kim, Su Yeon" uniqKey="Kim S" first="Su Yeon" last="Kim">Su Yeon Kim</name></author><author><name sortKey="Lee, Ki Won" sort="Lee, Ki Won" uniqKey="Lee K" first="Ki Won" last="Lee">Ki Won Lee</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21126077</idno><idno type="pmid">21126077</idno><idno type="doi">10.1021/jf103204x</idno><idno type="wicri:Area/PubMed/Corpus">000767</idno><idno type="wicri:Area/PubMed/Curation">000767</idno><idno type="wicri:Area/PubMed/Checkpoint">000767</idno><idno type="wicri:Area/Ncbi/Merge">000C72</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Tangeretin reduces ultraviolet B (UVB)-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking mitogen-activated protein kinase (MAPK) activation and reactive oxygen species (ROS) generation.</title><author><name sortKey="Yoon, Ji Hye" sort="Yoon, Ji Hye" uniqKey="Yoon J" first="Ji Hye" last="Yoon">Ji Hye Yoon</name><affiliation wicri:level="3"><nlm:affiliation>Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lim, Tae Gyu" sort="Lim, Tae Gyu" uniqKey="Lim T" first="Tae-Gyu" last="Lim">Tae-Gyu Lim</name></author><author><name sortKey="Lee, Kyung Mi" sort="Lee, Kyung Mi" uniqKey="Lee K" first="Kyung Mi" last="Lee">Kyung Mi Lee</name></author><author><name sortKey="Jeon, Ae Ji" sort="Jeon, Ae Ji" uniqKey="Jeon A" first="Ae Ji" last="Jeon">Ae Ji Jeon</name></author><author><name sortKey="Kim, Su Yeon" sort="Kim, Su Yeon" uniqKey="Kim S" first="Su Yeon" last="Kim">Su Yeon Kim</name></author><author><name sortKey="Lee, Ki Won" sort="Lee, Ki Won" uniqKey="Lee K" first="Ki Won" last="Lee">Ki Won Lee</name></author></analytic><series><title level="j">Journal of agricultural and food chemistry</title><idno type="eISSN">1520-5118</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Citrus sinensis (chemistry)</term><term>Cyclooxygenase 2 (genetics)</term><term>Cyclooxygenase 2 (metabolism)</term><term>Down-Regulation</term><term>Enzyme Activation (drug effects)</term><term>Enzyme Activation (radiation effects)</term><term>Epidermis (drug effects)</term><term>Epidermis (enzymology)</term><term>Epidermis (metabolism)</term><term>Epidermis (radiation effects)</term><term>Flavones (pharmacology)</term><term>Gene Expression Regulation, Enzymologic (drug effects)</term><term>Gene Expression Regulation, Enzymologic (radiation effects)</term><term>Mice</term><term>Mitogen-Activated Protein Kinases (genetics)</term><term>Mitogen-Activated Protein Kinases (metabolism)</term><term>Plant Extracts (pharmacology)</term><term>Reactive Oxygen Species (metabolism)</term><term>Signal Transduction (drug effects)</term><term>Ultraviolet Rays</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cyclooxygenase 2</term><term>Mitogen-Activated Protein Kinases</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Enzyme Activation</term><term>Epidermis</term><term>Gene Expression Regulation, Enzymologic</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Epidermis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclooxygenase 2</term><term>Epidermis</term><term>Mitogen-Activated Protein Kinases</term><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Flavones</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Enzyme Activation</term><term>Epidermis</term><term>Gene Expression Regulation, Enzymologic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Down-Regulation</term><term>Mice</term><term>Ultraviolet Rays</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present study examined the effects of tangeretin, a polymethoxylated flavonone present in citrus fruits, on ultraviolet B (UVB)-induced cyclooxygenase-2 (COX-2) expression in JB6 P+ mouse skin epidermal cells. Tangeretin suppressed UVB-induced COX-2 expression and transactivation of nuclear factor-κB and activator protein-1 in JB6 P+ cells. Moreover, tangeretin blocked UVB-induced phosphorylation of Akt and mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated protein kinase, c-Jun N-terminal kinase, and p38, and attenuated the phosphorylation of MAPK kinases 1/2, 3/6, and 4. Tangeretin also limited the endogenous generation of reactive oxygen species (ROS), thereby protecting the cells against oxidative stress. However, tangeretin did not scavenge the stable 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and influence the nicotinamide adenine dinucleotide phosphate oxidase activity. These results suggest that the anti-inflammatory effects of tangeretin stem from its modulation of cell signaling and suppression of intracellular ROS generation. Tangeretin may have a potent chemopreventive effect in skin cancer.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21126077</PMID><DateCreated><Year>2011</Year><Month>1</Month><Day>5</Day></DateCreated><DateCompleted><Year>2011</Year><Month>04</Month><Day>18</Day></DateCompleted><DateRevised><Year>2012</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1520-5118</ISSN><JournalIssue CitedMedium="Internet"><Volume>59</Volume><Issue>1</Issue><PubDate><Year>2011</Year><Month>Jan</Month><Day>12</Day></PubDate></JournalIssue><Title>Journal of agricultural and food chemistry</Title><ISOAbbreviation>J. Agric. Food Chem.</ISOAbbreviation></Journal><ArticleTitle>Tangeretin reduces ultraviolet B (UVB)-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking mitogen-activated protein kinase (MAPK) activation and reactive oxygen species (ROS) generation.</ArticleTitle><Pagination><MedlinePgn>222-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/jf103204x</ELocationID><Abstract><AbstractText>The present study examined the effects of tangeretin, a polymethoxylated flavonone present in citrus fruits, on ultraviolet B (UVB)-induced cyclooxygenase-2 (COX-2) expression in JB6 P+ mouse skin epidermal cells. Tangeretin suppressed UVB-induced COX-2 expression and transactivation of nuclear factor-κB and activator protein-1 in JB6 P+ cells. Moreover, tangeretin blocked UVB-induced phosphorylation of Akt and mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated protein kinase, c-Jun N-terminal kinase, and p38, and attenuated the phosphorylation of MAPK kinases 1/2, 3/6, and 4. Tangeretin also limited the endogenous generation of reactive oxygen species (ROS), thereby protecting the cells against oxidative stress. However, tangeretin did not scavenge the stable 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and influence the nicotinamide adenine dinucleotide phosphate oxidase activity. These results suggest that the anti-inflammatory effects of tangeretin stem from its modulation of cell signaling and suppression of intracellular ROS generation. Tangeretin may have a potent chemopreventive effect in skin cancer.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yoon</LastName><ForeName>Ji Hye</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, Seoul, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lim</LastName><ForeName>Tae-Gyu</ForeName><Initials>TG</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Kyung Mi</ForeName><Initials>KM</Initials></Author><Author ValidYN="Y"><LastName>Jeon</LastName><ForeName>Ae Ji</ForeName><Initials>AJ</Initials></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Su Yeon</ForeName><Initials>SY</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Ki Won</ForeName><Initials>KW</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>Dec</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Agric Food Chem</MedlineTA><NlmUniqueID>0374755</NlmUniqueID><ISSNLinking>0021-8561</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D047309">Flavones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.99.1</RegistryNumber><NameOfSubstance UI="D051546">Cyclooxygenase 2</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.24</RegistryNumber><NameOfSubstance UI="D020928">Mitogen-Activated Protein Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>I4TLA1DLX6</RegistryNumber><NameOfSubstance UI="C059006">tangeretin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="N">Citrus sinensis</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051546" MajorTopicYN="N">Cyclooxygenase 2</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015536" MajorTopicYN="Y">Down-Regulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004789" MajorTopicYN="N">Enzyme Activation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004817" MajorTopicYN="N">Epidermis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D047309" MajorTopicYN="N">Flavones</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015971" MajorTopicYN="N">Gene Expression Regulation, Enzymologic</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000528" MajorTopicYN="Y">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020928" MajorTopicYN="N">Mitogen-Activated Protein Kinases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014466" MajorTopicYN="N">Ultraviolet Rays</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>12</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>12</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>4</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21126077</ArticleId><ArticleId IdType="doi">10.1021/jf103204x</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><noCountry><name sortKey="Jeon, Ae Ji" sort="Jeon, Ae Ji" uniqKey="Jeon A" first="Ae Ji" last="Jeon">Ae Ji Jeon</name><name sortKey="Kim, Su Yeon" sort="Kim, Su Yeon" uniqKey="Kim S" first="Su Yeon" last="Kim">Su Yeon Kim</name><name sortKey="Lee, Ki Won" sort="Lee, Ki Won" uniqKey="Lee K" first="Ki Won" last="Lee">Ki Won Lee</name><name sortKey="Lee, Kyung Mi" sort="Lee, Kyung Mi" uniqKey="Lee K" first="Kyung Mi" last="Lee">Kyung Mi Lee</name><name sortKey="Lim, Tae Gyu" sort="Lim, Tae Gyu" uniqKey="Lim T" first="Tae-Gyu" last="Lim">Tae-Gyu Lim</name></noCountry><country name="Corée du Sud"><noRegion><name sortKey="Yoon, Ji Hye" sort="Yoon, Ji Hye" uniqKey="Yoon J" first="Ji Hye" last="Yoon">Ji Hye Yoon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix 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