Orange Juice and Hesperetin Supplementation to Hyperuricemic Rats Alter Oxidative Stress Markers and Xanthine Oxidoreductase Activity
Identifieur interne : 000A72 ( Ncbi/Merge ); précédent : 000A71; suivant : 000A73Orange Juice and Hesperetin Supplementation to Hyperuricemic Rats Alter Oxidative Stress Markers and Xanthine Oxidoreductase Activity
Auteurs : Fatemeh Haidari [Iran] ; Seid Ali Keshavarz [Iran] ; Mohammad Reza Rashidi [Iran] ; Majid Mohammad Shahi [Iran]Source :
- Journal of Clinical Biochemistry and Nutrition [ 0912-0009 ] ; 2009.
Abstract
Our objective was to examine the effect of orange juice and hesperetin on serum total antioxidant capacity (TAC), lipid peroxidation (MDA), uric acid and hepatic xanthine oxidase (XO) and xanthine dehydrogenase (XDH) activity in hyperuricemic rats. Experimentally hyperuricemia in rats was induced by intraperitoneal injection of potassium oxonate (250 mg/kg). Orange juice (5 ml/kg) and hesperetin (5 mg/kg) was given by oral gavage to rats for 2 weeks and biochemical data was measured. Data showed that orange juice supplementation increased serum TAC and decreased MDA concentration (
Url:
DOI: 10.3164/jcbn.09-15
PubMed: 19902018
PubMed Central: 2771249
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Orange Juice and Hesperetin Supplementation to Hyperuricemic Rats Alter Oxidative Stress Markers and Xanthine Oxidoreductase Activity</title><author><name sortKey="Haidari, Fatemeh" sort="Haidari, Fatemeh" uniqKey="Haidari F" first="Fatemeh" last="Haidari">Fatemeh Haidari</name><affiliation wicri:level="1"><nlm:aff id="aff1">Nutrition Department of Para-Medical School, Ahvaz Jondishapur University of Medical Sciences, Ahvaz 61357-15794, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Nutrition Department of Para-Medical School, Ahvaz Jondishapur University of Medical Sciences, Ahvaz 61357-15794</wicri:regionArea><wicri:noRegion>Ahvaz 61357-15794</wicri:noRegion></affiliation></author><author><name sortKey="Ali Keshavarz, Seid" sort="Ali Keshavarz, Seid" uniqKey="Ali Keshavarz S" first="Seid" last="Ali Keshavarz">Seid Ali Keshavarz</name><affiliation wicri:level="1"><nlm:aff id="aff2">Schools of Health and Institute of Public Health, Tehran University of Medical Science, Tehran 14176-14411, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Schools of Health and Institute of Public Health, Tehran University of Medical Science, Tehran 14176-14411</wicri:regionArea><wicri:noRegion>Tehran 14176-14411</wicri:noRegion></affiliation></author><author><name sortKey="Reza Rashidi, Mohammad" sort="Reza Rashidi, Mohammad" uniqKey="Reza Rashidi M" first="Mohammad" last="Reza Rashidi">Mohammad Reza Rashidi</name><affiliation wicri:level="1"><nlm:aff id="aff3">Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz 51664-14766, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz 51664-14766</wicri:regionArea><wicri:noRegion>Tabriz 51664-14766</wicri:noRegion></affiliation></author><author><name sortKey="Mohammad Shahi, Majid" sort="Mohammad Shahi, Majid" uniqKey="Mohammad Shahi M" first="Majid" last="Mohammad Shahi">Majid Mohammad Shahi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Nutrition Department of Para-Medical School, Ahvaz Jondishapur University of Medical Sciences, Ahvaz 61357-15794, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Nutrition Department of Para-Medical School, Ahvaz Jondishapur University of Medical Sciences, Ahvaz 61357-15794</wicri:regionArea><wicri:noRegion>Ahvaz 61357-15794</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19902018</idno><idno type="pmc">2771249</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771249</idno><idno type="RBID">PMC:2771249</idno><idno type="doi">10.3164/jcbn.09-15</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">001009</idno><idno type="wicri:Area/Pmc/Curation">001008</idno><idno type="wicri:Area/Pmc/Checkpoint">001007</idno><idno type="wicri:Area/Ncbi/Merge">000A72</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Orange Juice and Hesperetin Supplementation to Hyperuricemic Rats Alter Oxidative Stress Markers and Xanthine Oxidoreductase Activity</title><author><name sortKey="Haidari, Fatemeh" sort="Haidari, Fatemeh" uniqKey="Haidari F" first="Fatemeh" last="Haidari">Fatemeh Haidari</name><affiliation wicri:level="1"><nlm:aff id="aff1">Nutrition Department of Para-Medical School, Ahvaz Jondishapur University of Medical Sciences, Ahvaz 61357-15794, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Nutrition Department of Para-Medical School, Ahvaz Jondishapur University of Medical Sciences, Ahvaz 61357-15794</wicri:regionArea><wicri:noRegion>Ahvaz 61357-15794</wicri:noRegion></affiliation></author><author><name sortKey="Ali Keshavarz, Seid" sort="Ali Keshavarz, Seid" uniqKey="Ali Keshavarz S" first="Seid" last="Ali Keshavarz">Seid Ali Keshavarz</name><affiliation wicri:level="1"><nlm:aff id="aff2">Schools of Health and Institute of Public Health, Tehran University of Medical Science, Tehran 14176-14411, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Schools of Health and Institute of Public Health, Tehran University of Medical Science, Tehran 14176-14411</wicri:regionArea><wicri:noRegion>Tehran 14176-14411</wicri:noRegion></affiliation></author><author><name sortKey="Reza Rashidi, Mohammad" sort="Reza Rashidi, Mohammad" uniqKey="Reza Rashidi M" first="Mohammad" last="Reza Rashidi">Mohammad Reza Rashidi</name><affiliation wicri:level="1"><nlm:aff id="aff3">Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz 51664-14766, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz 51664-14766</wicri:regionArea><wicri:noRegion>Tabriz 51664-14766</wicri:noRegion></affiliation></author><author><name sortKey="Mohammad Shahi, Majid" sort="Mohammad Shahi, Majid" uniqKey="Mohammad Shahi M" first="Majid" last="Mohammad Shahi">Majid Mohammad Shahi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Nutrition Department of Para-Medical School, Ahvaz Jondishapur University of Medical Sciences, Ahvaz 61357-15794, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Nutrition Department of Para-Medical School, Ahvaz Jondishapur University of Medical Sciences, Ahvaz 61357-15794</wicri:regionArea><wicri:noRegion>Ahvaz 61357-15794</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Clinical Biochemistry and Nutrition</title><idno type="ISSN">0912-0009</idno><idno type="eISSN">1880-5086</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Our objective was to examine the effect of orange juice and hesperetin on serum total antioxidant capacity (TAC), lipid peroxidation (MDA), uric acid and hepatic xanthine oxidase (XO) and xanthine dehydrogenase (XDH) activity in hyperuricemic rats. Experimentally hyperuricemia in rats was induced by intraperitoneal injection of potassium oxonate (250 mg/kg). Orange juice (5 ml/kg) and hesperetin (5 mg/kg) was given by oral gavage to rats for 2 weeks and biochemical data was measured. Data showed that orange juice supplementation increased serum TAC and decreased MDA concentration (<italic>p</italic>≤0.05). Orange juice also inhibited hepatic XO and XDH activity and decreased serum uric acid levels. Hesperetin, which is the main flavanone constituent in orange juice, also exhibited antioxidative and antihyperuricemic properties, but its effect was weaker than that of orange juice. Although the hypouricemic effect of allopurinol (5 mg/kg), as a positive control, was much higher than that of orange juice and hesperetin, it could not significantly change biomarkers of oxidative stress. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Biochem Nutr</journal-id><journal-id journal-id-type="publisher-id">JCBN</journal-id><journal-title-group><journal-title>Journal of Clinical Biochemistry and Nutrition</journal-title></journal-title-group><issn pub-type="ppub">0912-0009</issn><issn pub-type="epub">1880-5086</issn><publisher><publisher-name>the Society for Free Radical Research Japan</publisher-name><publisher-loc>Kyoto, Japan</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19902018</article-id><article-id pub-id-type="pmc">2771249</article-id><article-id pub-id-type="publisher-id">jcbn09-15</article-id><article-id pub-id-type="doi">10.3164/jcbn.09-15</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Orange Juice and Hesperetin Supplementation to Hyperuricemic Rats Alter Oxidative Stress Markers and Xanthine Oxidoreductase Activity</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Haidari</surname><given-names>Fatemeh</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Ali Keshavarz</surname><given-names>Seid</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Reza Rashidi</surname><given-names>Mohammad</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Mohammad Shahi</surname><given-names>Majid</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Nutrition Department of Para-Medical School, Ahvaz Jondishapur University of Medical Sciences, Ahvaz 61357-15794, Iran</aff><aff id="aff2"><label>2</label>Schools of Health and Institute of Public Health, Tehran University of Medical Science, Tehran 14176-14411, Iran</aff><aff id="aff3"><label>3</label>Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz 51664-14766, Iran</aff><author-notes><corresp id="cor1">*To whom correspondence should be addressed. Tel: +98-611-3367550 Fax: +98-611-3367550 E-mail: <email>haidari58@gmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><month>11</month><year>2009</year></pub-date><pub-date pub-type="epub"><day>28</day><month>10</month><year>2009</year></pub-date><volume>45</volume><issue>3</issue><fpage>285</fpage><lpage>291</lpage><history><date date-type="received"><day>13</day><month>2</month><year>2009</year></date><date date-type="accepted"><day>20</day><month>3</month><year>2009</year></date></history><permissions><copyright-statement>Copyright © 2009 JCBN</copyright-statement><copyright-year>2009</copyright-year><license license-type="open-access"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Our objective was to examine the effect of orange juice and hesperetin on serum total antioxidant capacity (TAC), lipid peroxidation (MDA), uric acid and hepatic xanthine oxidase (XO) and xanthine dehydrogenase (XDH) activity in hyperuricemic rats. Experimentally hyperuricemia in rats was induced by intraperitoneal injection of potassium oxonate (250 mg/kg). Orange juice (5 ml/kg) and hesperetin (5 mg/kg) was given by oral gavage to rats for 2 weeks and biochemical data was measured. Data showed that orange juice supplementation increased serum TAC and decreased MDA concentration (<italic>p</italic>≤0.05). Orange juice also inhibited hepatic XO and XDH activity and decreased serum uric acid levels. Hesperetin, which is the main flavanone constituent in orange juice, also exhibited antioxidative and antihyperuricemic properties, but its effect was weaker than that of orange juice. Although the hypouricemic effect of allopurinol (5 mg/kg), as a positive control, was much higher than that of orange juice and hesperetin, it could not significantly change biomarkers of oxidative stress. These features of orange juice and hesperetin make them an attractive candidate for the prophylactic treatment of hyperuricaemia, particularly if these compounds are to be taken on a long-term basis.</p></abstract><kwd-group><kwd>antioxidant</kwd><kwd>flavonoids</kwd><kwd>uric acid</kwd><kwd>xanthine oxidase</kwd></kwd-group></article-meta></front><floats-group><fig id="F1" position="float"><label>Fig. 1</label><caption><p>Effect of orange juice, hesperetin and allopurinol on serum uric acid. All values are expressed as mean ± SD (<italic>n</italic> = 6). Independent-sample <italic>t</italic> test was used for statistical significance assessment. <bold>*</bold> indicates <italic>p</italic>≤0.05, <bold>**</bold> indicates <italic>p</italic>≤0.01 and <bold>***</bold> indicates <italic>p</italic>≤0.001 vs hyperuricemic control group. The number above bars means the percent of uric acid reduction vs hyperuricemic control group.</p></caption><graphic xlink:href="jcbn09-15f01"></graphic></fig><fig id="F2" position="float"><label>Fig. 2</label><caption><p>Linear regression between serum uric acid levels and MDA concentration</p></caption><graphic xlink:href="jcbn09-15f02"></graphic></fig><table-wrap id="T1" position="float"><label>Table 1</label><caption><p>Effect of orange juice, hesperetin and allopurinol on serum TAC and MDA</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Treatment</th><th align="center" rowspan="1" colspan="1">TAC (µmol/L)</th><th align="center" rowspan="1" colspan="1">MDA (µmol/L)</th></tr></thead><tbody><tr><td colspan="3" align="left" rowspan="1"><bold>Normal animal</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">Vehicle</td><td align="center" rowspan="1" colspan="1">275 ± 78.67*</td><td align="center" rowspan="1" colspan="1">3.41 ± 0.57</td></tr><tr><td colspan="3" align="left" rowspan="1"><bold>Hyperuricemic animal</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">PO + vehicle</td><td align="center" rowspan="1" colspan="1">213 ± 65.92<sup>#</sup></td><td align="center" rowspan="1" colspan="1">5.45 ± 0.89<sup>###</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">PO + orange juice (5 ml/kg)</td><td align="center" rowspan="1" colspan="1">280 ± 30.16*</td><td align="center" rowspan="1" colspan="1">4.04 ± 0.86*</td></tr><tr><td align="left" rowspan="1" colspan="1">PO + hesperetin (5 mg/kg)</td><td align="center" rowspan="1" colspan="1">271 ± 52.31</td><td align="center" rowspan="1" colspan="1">4.95 ± 0.71<sup>##</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">PO + allopurinol (5 mg/kg)</td><td align="center" rowspan="1" colspan="1">244 ± 57.27</td><td align="center" rowspan="1" colspan="1">5.00 ± 0.92<sup>##</sup></td></tr></tbody></table><table-wrap-foot><p>All values are expressed as mean ± SD (<italic>n</italic> = 6). Independent-sample <italic>t</italic> test was used for statistical significance assessment. * indicates <italic>p</italic>≤0.05 vs hyperuricemic control group, <sup>#</sup> indicates <italic>p</italic>≤0.05, <sup>##</sup> indicates <italic>p</italic>≤0.01 and <sup>###</sup> indicates <italic>p</italic>≤0.001 vs normal control group.</p></table-wrap-foot></table-wrap><table-wrap id="T2" position="float"><label>Table 2</label><caption><p>Effect of orange juice, hesperetin and allopurinol on hepatic XO and XDH activity</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Treatment</th><th colspan="2" align="center" rowspan="1">Activity (U/mg protein)<hr></hr></th><th colspan="2" align="center" rowspan="1">Inhibition %<hr></hr></th></tr><tr><th rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1">XO</th><th align="center" rowspan="1" colspan="1">XDH</th><th align="center" rowspan="1" colspan="1">XO</th><th align="center" rowspan="1" colspan="1">XDH</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1"><bold>Normal animal</bold></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Vehicle</td><td align="center" rowspan="1" colspan="1">2.50 ± 0.63</td><td align="center" rowspan="1" colspan="1">3.80 ± 0.38</td><td align="center" rowspan="1" colspan="1">—</td><td align="center" rowspan="1" colspan="1">—</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Hyperuricemic animal</bold></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">PO + vehicle</td><td align="center" rowspan="1" colspan="1">2.49 ± 0.52</td><td align="center" rowspan="1" colspan="1">3.82 ± 0.62</td><td align="center" rowspan="1" colspan="1">—</td><td align="center" rowspan="1" colspan="1">—</td></tr><tr><td align="left" rowspan="1" colspan="1">PO + orange juice (5 ml/kg)</td><td align="center" rowspan="1" colspan="1">1.88 ± 0.37*<sup>,#</sup></td><td align="center" rowspan="1" colspan="1">2.64 ± 0.20***<sup>,###</sup></td><td align="center" rowspan="1" colspan="1">24.49</td><td align="center" rowspan="1" colspan="1">30.89</td></tr><tr><td align="left" rowspan="1" colspan="1">PO + hesperetin (5 mg/kg)</td><td align="center" rowspan="1" colspan="1">1.90 ± 0.37*<sup>,#</sup></td><td align="center" rowspan="1" colspan="1">3.03 ± 0.29*<sup>,##</sup></td><td align="center" rowspan="1" colspan="1">23.69</td><td align="center" rowspan="1" colspan="1">20.68</td></tr><tr><td align="left" rowspan="1" colspan="1">PO + allopurinol (5 mg/kg)</td><td align="center" rowspan="1" colspan="1">1.05 ± 0.18***<sup>,###</sup></td><td align="center" rowspan="1" colspan="1">1.27 ± 0.33***<sup>,###</sup></td><td align="center" rowspan="1" colspan="1">57.83</td><td align="center" rowspan="1" colspan="1">66.75</td></tr></tbody></table><table-wrap-foot><p>All values are expressed as mean ± SD (<italic>n</italic> = 6). Independent-sample <italic>t</italic> test was used for statistical significance assessment. * indicates <italic>p</italic>≤0.05, and *** indicates <italic>p</italic>≤0.001 vs hyperuricemic control group, <sup>#</sup> indicates <italic>p</italic>≤0.05, <sup>##</sup> indicates <italic>p</italic>≤0.01 and <sup>###</sup> indicates <italic>p</italic>≤0.001 vs normal control group.</p></table-wrap-foot></table-wrap></floats-group></pmc><affiliations><list><country><li>Iran</li></country></list><tree><country name="Iran"><noRegion><name sortKey="Haidari, Fatemeh" sort="Haidari, Fatemeh" uniqKey="Haidari F" first="Fatemeh" last="Haidari">Fatemeh Haidari</name></noRegion><name sortKey="Ali Keshavarz, Seid" sort="Ali Keshavarz, Seid" uniqKey="Ali Keshavarz S" first="Seid" last="Ali Keshavarz">Seid Ali Keshavarz</name><name sortKey="Mohammad Shahi, Majid" sort="Mohammad Shahi, Majid" uniqKey="Mohammad Shahi M" first="Majid" last="Mohammad Shahi">Majid Mohammad Shahi</name><name sortKey="Reza Rashidi, Mohammad" sort="Reza Rashidi, Mohammad" uniqKey="Reza Rashidi M" first="Mohammad" last="Reza Rashidi">Mohammad Reza Rashidi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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