Intraplantar injection of bergamot essential oil into the mouse hindpaw: effects on capsaicin-induced nociceptive behaviors.
Identifieur interne : 000A26 ( Ncbi/Merge ); précédent : 000A25; suivant : 000A27Intraplantar injection of bergamot essential oil into the mouse hindpaw: effects on capsaicin-induced nociceptive behaviors.
Auteurs : Tsukasa Sakurada [Japon] ; Hikari Kuwahata ; Soh Katsuyama ; Takaaki Komatsu ; Luigi Antonio Morrone ; Maria Tiziana Corasaniti ; Giacinto Bagetta ; Shinobu SakuradaSource :
- International review of neurobiology [ 0074-7742 ] ; 2009.
English descriptors
- KwdEn :
- Analgesics (isolation & purification), Analgesics (pharmacology), Animals, Capsaicin (administration & dosage), Capsaicin (pharmacology), Hindlimb, Injections, Intralesional, Mice, Molecular Structure, Monoterpenes (chemistry), Monoterpenes (isolation & purification), Monoterpenes (pharmacology), Oils, Volatile (administration & dosage), Oils, Volatile (chemistry), Oils, Volatile (pharmacology), Pain (chemically induced), Pain (drug therapy), Plant Oils (administration & dosage), Plant Oils (chemistry), Plant Oils (pharmacology).
- MESH :
- chemical , administration & dosage : Capsaicin, Oils, Volatile, Plant Oils.
- chemical , chemistry : Monoterpenes, Oils, Volatile, Plant Oils.
- chemical , isolation & purification : Analgesics, Monoterpenes.
- chemical , pharmacology : Analgesics, Capsaicin, Monoterpenes, Oils, Volatile, Plant Oils.
- chemically induced : Pain.
- drug therapy : Pain.
- Animals, Hindlimb, Injections, Intralesional, Mice, Molecular Structure.
Abstract
Despite the increasing use of aromatherapy oils, there have not been many studies exploring the biological activities of bergamot (Citrus bergamia, Risso) essential oil (BEO). Recently, we have investigated the effects of BEO injected into the plantar surface of the hindpaw in the capsaicin test in mice. The intraplantar injection of capsaicin produced an intense and short-lived licking/biting response toward the injected hindpaw. The capsaicin-induced nociceptive response was reduced significantly by intraplantar injection of BEO. The essential oils of Clary Sage (Salvia sclarea), Thyme ct. linalool (linalool chemotype of Thymus vulgaris), Lavender Reydovan (Lavandula hybrida reydovan), and True Lavender (Lavandula angustifolia), had similar antinociceptive effects on the capsaicin-induced nociceptive response, while Orange Sweet (Citrus sinensis) essential oil was without effect. In contrast to a small number of pharmacological studies of BEO, there is ample evidence regarding isolated components of BEO which are also found in other essential oils. The most abundant compounds found in the volatile fraction are the monoterpene hydrocarbons, such as limonene, gamma-terpinene, beta-pinene, and oxygenated derivatives, linalool and linalyl acetate. Of these monoterpenes, the pharmacological activities of linalool have been examined. Following intraperitoneal (i.p.) administration in mice, linalool produces antinociceptive and antihyperalgesic effects in different animal models in addition to anti-inflammatory properties. Linalool also possesses anticonvulsant activity in experimental models of epilepsy. We address the importance of linalool or linalyl acetate in BEO-or the other essential oil-induced antinociception.
DOI: 10.1016/S0074-7742(09)85018-6
PubMed: 19607974
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Katsuyama</name></author><author><name sortKey="Komatsu, Takaaki" sort="Komatsu, Takaaki" uniqKey="Komatsu T" first="Takaaki" last="Komatsu">Takaaki Komatsu</name></author><author><name sortKey="Morrone, Luigi Antonio" sort="Morrone, Luigi Antonio" uniqKey="Morrone L" first="Luigi Antonio" last="Morrone">Luigi Antonio Morrone</name></author><author><name sortKey="Corasaniti, Maria Tiziana" sort="Corasaniti, Maria Tiziana" uniqKey="Corasaniti M" first="Maria Tiziana" last="Corasaniti">Maria Tiziana Corasaniti</name></author><author><name sortKey="Bagetta, Giacinto" sort="Bagetta, Giacinto" uniqKey="Bagetta G" first="Giacinto" last="Bagetta">Giacinto Bagetta</name></author><author><name sortKey="Sakurada, Shinobu" sort="Sakurada, Shinobu" uniqKey="Sakurada S" first="Shinobu" last="Sakurada">Shinobu Sakurada</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19607974</idno><idno 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last="Bagetta">Giacinto Bagetta</name></author><author><name sortKey="Sakurada, Shinobu" sort="Sakurada, Shinobu" uniqKey="Sakurada S" first="Shinobu" last="Sakurada">Shinobu Sakurada</name></author></analytic><series><title level="j">International review of neurobiology</title><idno type="ISSN">0074-7742</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analgesics (isolation & purification)</term><term>Analgesics (pharmacology)</term><term>Animals</term><term>Capsaicin (administration & dosage)</term><term>Capsaicin (pharmacology)</term><term>Hindlimb</term><term>Injections, Intralesional</term><term>Mice</term><term>Molecular Structure</term><term>Monoterpenes (chemistry)</term><term>Monoterpenes (isolation & purification)</term><term>Monoterpenes (pharmacology)</term><term>Oils, Volatile (administration & dosage)</term><term>Oils, Volatile (chemistry)</term><term>Oils, Volatile (pharmacology)</term><term>Pain (chemically induced)</term><term>Pain (drug therapy)</term><term>Plant Oils (administration & dosage)</term><term>Plant Oils (chemistry)</term><term>Plant Oils (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Capsaicin</term><term>Oils, Volatile</term><term>Plant Oils</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Monoterpenes</term><term>Oils, Volatile</term><term>Plant Oils</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Analgesics</term><term>Monoterpenes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Analgesics</term><term>Capsaicin</term><term>Monoterpenes</term><term>Oils, Volatile</term><term>Plant Oils</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Pain</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Pain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Hindlimb</term><term>Injections, Intralesional</term><term>Mice</term><term>Molecular Structure</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite the increasing use of aromatherapy oils, there have not been many studies exploring the biological activities of bergamot (Citrus bergamia, Risso) essential oil (BEO). Recently, we have investigated the effects of BEO injected into the plantar surface of the hindpaw in the capsaicin test in mice. The intraplantar injection of capsaicin produced an intense and short-lived licking/biting response toward the injected hindpaw. The capsaicin-induced nociceptive response was reduced significantly by intraplantar injection of BEO. The essential oils of Clary Sage (Salvia sclarea), Thyme ct. linalool (linalool chemotype of Thymus vulgaris), Lavender Reydovan (Lavandula hybrida reydovan), and True Lavender (Lavandula angustifolia), had similar antinociceptive effects on the capsaicin-induced nociceptive response, while Orange Sweet (Citrus sinensis) essential oil was without effect. In contrast to a small number of pharmacological studies of BEO, there is ample evidence regarding isolated components of BEO which are also found in other essential oils. The most abundant compounds found in the volatile fraction are the monoterpene hydrocarbons, such as limonene, gamma-terpinene, beta-pinene, and oxygenated derivatives, linalool and linalyl acetate. Of these monoterpenes, the pharmacological activities of linalool have been examined. Following intraperitoneal (i.p.) administration in mice, linalool produces antinociceptive and antihyperalgesic effects in different animal models in addition to anti-inflammatory properties. Linalool also possesses anticonvulsant activity in experimental models of epilepsy. We address the importance of linalool or linalyl acetate in BEO-or the other essential oil-induced antinociception.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19607974</PMID><DateCreated><Year>2009</Year><Month>7</Month><Day>17</Day></DateCreated><DateCompleted><Year>2009</Year><Month>09</Month><Day>10</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0074-7742</ISSN><JournalIssue CitedMedium="Print"><Volume>85</Volume><PubDate><Year>2009</Year></PubDate></JournalIssue><Title>International review of neurobiology</Title><ISOAbbreviation>Int. Rev. Neurobiol.</ISOAbbreviation></Journal><ArticleTitle>Intraplantar injection of bergamot essential oil into the mouse hindpaw: effects on capsaicin-induced nociceptive behaviors.</ArticleTitle><Pagination><MedlinePgn>237-48</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/S0074-7742(09)85018-6</ELocationID><Abstract><AbstractText>Despite the increasing use of aromatherapy oils, there have not been many studies exploring the biological activities of bergamot (Citrus bergamia, Risso) essential oil (BEO). Recently, we have investigated the effects of BEO injected into the plantar surface of the hindpaw in the capsaicin test in mice. The intraplantar injection of capsaicin produced an intense and short-lived licking/biting response toward the injected hindpaw. The capsaicin-induced nociceptive response was reduced significantly by intraplantar injection of BEO. The essential oils of Clary Sage (Salvia sclarea), Thyme ct. linalool (linalool chemotype of Thymus vulgaris), Lavender Reydovan (Lavandula hybrida reydovan), and True Lavender (Lavandula angustifolia), had similar antinociceptive effects on the capsaicin-induced nociceptive response, while Orange Sweet (Citrus sinensis) essential oil was without effect. In contrast to a small number of pharmacological studies of BEO, there is ample evidence regarding isolated components of BEO which are also found in other essential oils. The most abundant compounds found in the volatile fraction are the monoterpene hydrocarbons, such as limonene, gamma-terpinene, beta-pinene, and oxygenated derivatives, linalool and linalyl acetate. Of these monoterpenes, the pharmacological activities of linalool have been examined. Following intraperitoneal (i.p.) administration in mice, linalool produces antinociceptive and antihyperalgesic effects in different animal models in addition to anti-inflammatory properties. Linalool also possesses anticonvulsant activity in experimental models of epilepsy. We address the importance of linalool or linalyl acetate in BEO-or the other essential oil-induced antinociception.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sakurada</LastName><ForeName>Tsukasa</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>First Department of Pharmacology, Daiichi College of Pharmaceutical Sciences, Fukuoka, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuwahata</LastName><ForeName>Hikari</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Katsuyama</LastName><ForeName>Soh</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Komatsu</LastName><ForeName>Takaaki</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Morrone</LastName><ForeName>Luigi Antonio</ForeName><Initials>LA</Initials></Author><Author ValidYN="Y"><LastName>Corasaniti</LastName><ForeName>Maria Tiziana</ForeName><Initials>MT</Initials></Author><Author ValidYN="Y"><LastName>Bagetta</LastName><ForeName>Giacinto</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Sakurada</LastName><ForeName>Shinobu</ForeName><Initials>S</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Int Rev Neurobiol</MedlineTA><NlmUniqueID>0374740</NlmUniqueID><ISSNLinking>0074-7742</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000700">Analgesics</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D039821">Monoterpenes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009822">Oils, Volatile</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010938">Plant Oils</NameOfSubstance></Chemical><Chemical><RegistryNumber>5K47SSQ51G</RegistryNumber><NameOfSubstance UI="C074463">linalyl acetate</NameOfSubstance></Chemical><Chemical><RegistryNumber>8007-75-8</RegistryNumber><NameOfSubstance UI="C068336">bergamot oil</NameOfSubstance></Chemical><Chemical><RegistryNumber>D81QY6I88E</RegistryNumber><NameOfSubstance UI="C018584">linalool</NameOfSubstance></Chemical><Chemical><RegistryNumber>S07O44R1ZM</RegistryNumber><NameOfSubstance UI="D002211">Capsaicin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000700" MajorTopicYN="N">Analgesics</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002211" MajorTopicYN="N">Capsaicin</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006614" MajorTopicYN="N">Hindlimb</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015552" MajorTopicYN="N">Injections, Intralesional</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015394" MajorTopicYN="N">Molecular Structure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D039821" MajorTopicYN="N">Monoterpenes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009822" MajorTopicYN="N">Oils, Volatile</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010146" MajorTopicYN="N">Pain</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010938" MajorTopicYN="N">Plant Oils</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading></MeshHeadingList><NumberOfReferences>49</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>7</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>7</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>9</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19607974</ArticleId><ArticleId IdType="pii">S0074-7742(09)85018-6</ArticleId><ArticleId IdType="doi">10.1016/S0074-7742(09)85018-6</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Bagetta, Giacinto" sort="Bagetta, Giacinto" uniqKey="Bagetta G" first="Giacinto" last="Bagetta">Giacinto Bagetta</name><name sortKey="Corasaniti, Maria Tiziana" sort="Corasaniti, Maria Tiziana" uniqKey="Corasaniti M" first="Maria Tiziana" last="Corasaniti">Maria Tiziana Corasaniti</name><name sortKey="Katsuyama, Soh" sort="Katsuyama, Soh" uniqKey="Katsuyama S" first="Soh" last="Katsuyama">Soh Katsuyama</name><name sortKey="Komatsu, Takaaki" sort="Komatsu, Takaaki" uniqKey="Komatsu T" first="Takaaki" last="Komatsu">Takaaki Komatsu</name><name sortKey="Kuwahata, Hikari" sort="Kuwahata, Hikari" uniqKey="Kuwahata H" first="Hikari" last="Kuwahata">Hikari Kuwahata</name><name sortKey="Morrone, Luigi Antonio" sort="Morrone, Luigi Antonio" uniqKey="Morrone L" first="Luigi Antonio" last="Morrone">Luigi Antonio Morrone</name><name sortKey="Sakurada, Shinobu" sort="Sakurada, Shinobu" uniqKey="Sakurada S" first="Shinobu" last="Sakurada">Shinobu Sakurada</name></noCountry><country name="Japon"><noRegion><name sortKey="Sakurada, Tsukasa" sort="Sakurada, Tsukasa" uniqKey="Sakurada T" first="Tsukasa" last="Sakurada">Tsukasa Sakurada</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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