Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans.
Identifieur interne : 000996 ( Ncbi/Merge ); précédent : 000995; suivant : 000997Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans.
Auteurs : Suri Roowi [Royaume-Uni] ; William Mullen ; Christine A. Edwards ; Alan CrozierSource :
- Molecular nutrition & food research [ 1613-4133 ] ; 2009.
English descriptors
- KwdEn :
- Adult, Beverages (analysis), Carboxylic Acids (urine), Citrus sinensis (chemistry), Colon (microbiology), Flavanones (administration & dosage), Flavanones (analysis), Flavanones (metabolism), Fruit (chemistry), Gas Chromatography-Mass Spectrometry, Hesperidin (analysis), Hesperidin (metabolism), Humans, Middle Aged, Yogurt.
- MESH :
- chemical , administration & dosage : Flavanones.
- chemical , analysis : Flavanones, Hesperidin.
- chemical , metabolism : Flavanones, Hesperidin.
- chemical , urine : Carboxylic Acids.
- analysis : Beverages.
- chemistry : Citrus sinensis, Fruit.
- microbiology : Colon.
- Adult, Gas Chromatography-Mass Spectrometry, Humans, Middle Aged, Yogurt.
Abstract
Human urine was collected over a 24 h period after the consumption of 250 mL of (i) water, (ii) orange juice, and (iii) orange juice plus 150 mL of full fat natural yoghurt. The orange juice contained 168 micromol of hesperetin-7-O-rutinoside and 18 micromol of naringenin-7-O-rutinoside. GC-MS analysis of the urine identified nine phenolic acids, five of which, 3-hydroxyphenylacetic acid, 3-hydroxyphenylhydracrylic acid, dihydroferulic acid, 3-methoxy-4-hydroxyphenylhydracrylic acid and 3-hydroxyhippuric acid, were associated with orange juice consumption indicating that they were derived from colonic catabolism of hesperetin-7-O-rutinoside. The overall 0-24 h excretion of the five phenolic acids was 6.7 +/- 1.8 micromol after drinking water and this increased significantly (p < 0.05) to 62 +/- 18 micromol, equivalent to 37% of the ingested flavanones, following orange juice consumption. When the orange juice was ingested with yoghurt excretion fell back markedly to 9.3 +/- 4.4 micromol. This was not due to a difference in mouth to caecum transit time, as measured with breath hydrogen production, though possibly there may have been a slowing of the bulk of the meal reaching the large intestine which may then have altered the catabolism of the flavanones to phenolic acids by the colonic microbiota.
DOI: 10.1002/mnfr.200800287
PubMed: 19415668
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Edwards</name></author><author><name sortKey="Crozier, Alan" sort="Crozier, Alan" uniqKey="Crozier A" first="Alan" last="Crozier">Alan Crozier</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19415668</idno><idno type="pmid">19415668</idno><idno type="doi">10.1002/mnfr.200800287</idno><idno type="wicri:Area/PubMed/Corpus">000958</idno><idno type="wicri:Area/PubMed/Curation">000958</idno><idno type="wicri:Area/PubMed/Checkpoint">000958</idno><idno type="wicri:Area/Ncbi/Merge">000996</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans.</title><author><name sortKey="Roowi, Suri" sort="Roowi, Suri" uniqKey="Roowi S" first="Suri" last="Roowi">Suri Roowi</name><affiliation wicri:level="4"><nlm:affiliation>Division of Environmental and Evolutionary Biology, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Environmental and Evolutionary Biology, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Mullen, William" sort="Mullen, William" uniqKey="Mullen W" first="William" last="Mullen">William Mullen</name></author><author><name sortKey="Edwards, Christine A" sort="Edwards, Christine A" uniqKey="Edwards C" first="Christine A" last="Edwards">Christine A. Edwards</name></author><author><name sortKey="Crozier, Alan" sort="Crozier, Alan" uniqKey="Crozier A" first="Alan" last="Crozier">Alan Crozier</name></author></analytic><series><title level="j">Molecular nutrition & food research</title><idno type="eISSN">1613-4133</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Beverages (analysis)</term><term>Carboxylic Acids (urine)</term><term>Citrus sinensis (chemistry)</term><term>Colon (microbiology)</term><term>Flavanones (administration & dosage)</term><term>Flavanones (analysis)</term><term>Flavanones (metabolism)</term><term>Fruit (chemistry)</term><term>Gas Chromatography-Mass Spectrometry</term><term>Hesperidin (analysis)</term><term>Hesperidin (metabolism)</term><term>Humans</term><term>Middle Aged</term><term>Yogurt</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Flavanones</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Flavanones</term><term>Hesperidin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Flavanones</term><term>Hesperidin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Carboxylic Acids</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Beverages</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term><term>Fruit</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Colon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Gas Chromatography-Mass Spectrometry</term><term>Humans</term><term>Middle Aged</term><term>Yogurt</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Human urine was collected over a 24 h period after the consumption of 250 mL of (i) water, (ii) orange juice, and (iii) orange juice plus 150 mL of full fat natural yoghurt. The orange juice contained 168 micromol of hesperetin-7-O-rutinoside and 18 micromol of naringenin-7-O-rutinoside. GC-MS analysis of the urine identified nine phenolic acids, five of which, 3-hydroxyphenylacetic acid, 3-hydroxyphenylhydracrylic acid, dihydroferulic acid, 3-methoxy-4-hydroxyphenylhydracrylic acid and 3-hydroxyhippuric acid, were associated with orange juice consumption indicating that they were derived from colonic catabolism of hesperetin-7-O-rutinoside. The overall 0-24 h excretion of the five phenolic acids was 6.7 +/- 1.8 micromol after drinking water and this increased significantly (p < 0.05) to 62 +/- 18 micromol, equivalent to 37% of the ingested flavanones, following orange juice consumption. When the orange juice was ingested with yoghurt excretion fell back markedly to 9.3 +/- 4.4 micromol. This was not due to a difference in mouth to caecum transit time, as measured with breath hydrogen production, though possibly there may have been a slowing of the bulk of the meal reaching the large intestine which may then have altered the catabolism of the flavanones to phenolic acids by the colonic microbiota.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19415668</PMID><DateCreated><Year>2009</Year><Month>6</Month><Day>3</Day></DateCreated><DateCompleted><Year>2009</Year><Month>08</Month><Day>27</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1613-4133</ISSN><JournalIssue CitedMedium="Internet"><Volume>53 Suppl 1</Volume><PubDate><Year>2009</Year><Month>May</Month></PubDate></JournalIssue><Title>Molecular nutrition & food research</Title><ISOAbbreviation>Mol Nutr Food Res</ISOAbbreviation></Journal><ArticleTitle>Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans.</ArticleTitle><Pagination><MedlinePgn>S68-75</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mnfr.200800287</ELocationID><Abstract><AbstractText>Human urine was collected over a 24 h period after the consumption of 250 mL of (i) water, (ii) orange juice, and (iii) orange juice plus 150 mL of full fat natural yoghurt. The orange juice contained 168 micromol of hesperetin-7-O-rutinoside and 18 micromol of naringenin-7-O-rutinoside. GC-MS analysis of the urine identified nine phenolic acids, five of which, 3-hydroxyphenylacetic acid, 3-hydroxyphenylhydracrylic acid, dihydroferulic acid, 3-methoxy-4-hydroxyphenylhydracrylic acid and 3-hydroxyhippuric acid, were associated with orange juice consumption indicating that they were derived from colonic catabolism of hesperetin-7-O-rutinoside. The overall 0-24 h excretion of the five phenolic acids was 6.7 +/- 1.8 micromol after drinking water and this increased significantly (p < 0.05) to 62 +/- 18 micromol, equivalent to 37% of the ingested flavanones, following orange juice consumption. When the orange juice was ingested with yoghurt excretion fell back markedly to 9.3 +/- 4.4 micromol. This was not due to a difference in mouth to caecum transit time, as measured with breath hydrogen production, though possibly there may have been a slowing of the bulk of the meal reaching the large intestine which may then have altered the catabolism of the flavanones to phenolic acids by the colonic microbiota.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Roowi</LastName><ForeName>Suri</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Environmental and Evolutionary Biology, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mullen</LastName><ForeName>William</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Edwards</LastName><ForeName>Christine A</ForeName><Initials>CA</Initials></Author><Author ValidYN="Y"><LastName>Crozier</LastName><ForeName>Alan</ForeName><Initials>A</Initials></Author></AuthorList><Language>ENG</Language><GrantList CompleteYN="Y"><Grant><Agency>Biotechnology and Biological Sciences Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Mol Nutr Food Res</MedlineTA><NlmUniqueID>101231818</NlmUniqueID><ISSNLinking>1613-4125</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002264">Carboxylic Acids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044950">Flavanones</NameOfSubstance></Chemical><Chemical><RegistryNumber>E750O06Y6O</RegistryNumber><NameOfSubstance UI="D006569">Hesperidin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001628" MajorTopicYN="N">Beverages</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002264" MajorTopicYN="N">Carboxylic Acids</DescriptorName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="N">Citrus sinensis</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003106" MajorTopicYN="N">Colon</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044950" MajorTopicYN="N">Flavanones</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005638" MajorTopicYN="N">Fruit</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008401" MajorTopicYN="N">Gas Chromatography-Mass Spectrometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006569" MajorTopicYN="N">Hesperidin</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015014" MajorTopicYN="Y">Yogurt</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>5</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>5</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>8</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19415668</ArticleId><ArticleId IdType="doi">10.1002/mnfr.200800287</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Écosse</li></region><settlement><li>Glasgow</li></settlement><orgName><li>Université de Glasgow</li></orgName></list><tree><noCountry><name sortKey="Crozier, Alan" sort="Crozier, Alan" uniqKey="Crozier A" first="Alan" last="Crozier">Alan Crozier</name><name sortKey="Edwards, Christine A" sort="Edwards, Christine A" uniqKey="Edwards C" first="Christine A" last="Edwards">Christine A. Edwards</name><name sortKey="Mullen, William" sort="Mullen, William" uniqKey="Mullen W" first="William" last="Mullen">William Mullen</name></noCountry><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Roowi, Suri" sort="Roowi, Suri" uniqKey="Roowi S" first="Suri" last="Roowi">Suri Roowi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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