Encapsulation and micronization effectively improve orange beverage flavanone bioavailability in humans.
Identifieur interne : 001828 ( Ncbi/Checkpoint ); précédent : 001827; suivant : 001829Encapsulation and micronization effectively improve orange beverage flavanone bioavailability in humans.
Auteurs : María Tomás-Navarro [Espagne] ; Fernando Vallejo ; Francisco Borrego ; Francisco A. Tomás-BarberánSource :
- Journal of agricultural and food chemistry [ 1520-5118 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Hesperidin.
- analysis : Beverages.
- chemistry : Citrus sinensis.
- methods : Drug Compounding.
- chemical , pharmacokinetics : Hesperidin.
- Adult, Biological Availability, Humans, Male, Middle Aged, Particle Size.
Abstract
The effect of hesperidin encapsulation and particle size reduction on hesperetin bioavailability was assessed after the intake of orange flavanone beverages. Hesperidin micronization (5.1 μm) increased flavanone's bioavailability 2-fold compared to conventional hesperidin (32.8 μm). Gum Arabic encapsulated hesperidin, with enhanced dispersion in water, also showed increased bioavailability despite having a higher particle size than conventional hesperidin (74.2 μm), showing that flavanone dispersion also enhances its bioavailability. The bioavailability of micronized hesperetin was also evaluated to overcome the need for gut microbiota rhamnosidase hydrolysis. When volunteers were stratified for their flavanone excretion capability, differences among treatments were better observed. The treatments used to increase solubility and decrease particle size to facilitate the interaction with intestinal cells and gut microbiota enhanced bioavailabilty especially in high (9.2 ± 1.5 mg) and medium (5.5 ± 0.3 mg) flavanone excretors. On the contrary, micronized hesperetin bioavailability was particularly high in the case of low excretors (4.3 ± 0.6 mg), showing that the low excretion in these volunteers should be associated with the lack of the appropriate microbiota to release hesperetin from hesperidin. Not all of the low excretors, however, reached the excretion levels of high excretors when hesperetin was supplied, suggesting that differences in intestinal transporters of the volunteers could also affect the flavanone excretion rates observed.
DOI: 10.1021/jf502933v
PubMed: 25200135
Affiliations:
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pubmed:25200135Le document en format XML
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Tomás-Barberán</name></author></analytic><series><title level="j">Journal of agricultural and food chemistry</title><idno type="eISSN">1520-5118</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Beverages (analysis)</term><term>Biological Availability</term><term>Citrus sinensis (chemistry)</term><term>Drug Compounding (methods)</term><term>Hesperidin (chemistry)</term><term>Hesperidin (pharmacokinetics)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Particle Size</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Hesperidin</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Beverages</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Compounding</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Hesperidin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Biological Availability</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Particle Size</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effect of hesperidin encapsulation and particle size reduction on hesperetin bioavailability was assessed after the intake of orange flavanone beverages. Hesperidin micronization (5.1 μm) increased flavanone's bioavailability 2-fold compared to conventional hesperidin (32.8 μm). Gum Arabic encapsulated hesperidin, with enhanced dispersion in water, also showed increased bioavailability despite having a higher particle size than conventional hesperidin (74.2 μm), showing that flavanone dispersion also enhances its bioavailability. The bioavailability of micronized hesperetin was also evaluated to overcome the need for gut microbiota rhamnosidase hydrolysis. When volunteers were stratified for their flavanone excretion capability, differences among treatments were better observed. The treatments used to increase solubility and decrease particle size to facilitate the interaction with intestinal cells and gut microbiota enhanced bioavailabilty especially in high (9.2 ± 1.5 mg) and medium (5.5 ± 0.3 mg) flavanone excretors. On the contrary, micronized hesperetin bioavailability was particularly high in the case of low excretors (4.3 ± 0.6 mg), showing that the low excretion in these volunteers should be associated with the lack of the appropriate microbiota to release hesperetin from hesperidin. Not all of the low excretors, however, reached the excretion levels of high excretors when hesperetin was supplied, suggesting that differences in intestinal transporters of the volunteers could also affect the flavanone excretion rates observed.</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Région de Murcie</li></region></list><tree><noCountry><name sortKey="Borrego, Francisco" sort="Borrego, Francisco" uniqKey="Borrego F" first="Francisco" last="Borrego">Francisco Borrego</name><name sortKey="Tomas Barberan, Francisco A" sort="Tomas Barberan, Francisco A" uniqKey="Tomas Barberan F" first="Francisco A" last="Tomás-Barberán">Francisco A. Tomás-Barberán</name><name sortKey="Vallejo, Fernando" sort="Vallejo, Fernando" uniqKey="Vallejo F" first="Fernando" last="Vallejo">Fernando Vallejo</name></noCountry><country name="Espagne"><region name="Région de Murcie"><name sortKey="Tomas Navarro, Maria" sort="Tomas Navarro, Maria" uniqKey="Tomas Navarro M" first="María" last="Tomás-Navarro">María Tomás-Navarro</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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