Oral dose of citrus peel extracts promotes wound repair in diabetic rats.
Identifieur interne : 001586 ( Ncbi/Checkpoint ); précédent : 001585; suivant : 001587Oral dose of citrus peel extracts promotes wound repair in diabetic rats.
Auteurs : M. Ahmad ; M N Ansari ; A. Alam ; T H KhanSource :
- Pakistan journal of biological sciences : PJBS [ 1028-8880 ] ; 2013.
English descriptors
- KwdEn :
- Administration, Oral, Alkaloids (metabolism), Animals, Ascorbic Acid (metabolism), Blood Glucose (drug effects), Body Weight (drug effects), Carotenoids (metabolism), Citrus (chemistry), Collagen (metabolism), Diabetes Mellitus, Experimental (metabolism), Diabetes Mellitus, Experimental (pathology), Male, Plant Extracts (chemistry), Plant Extracts (pharmacology), Rats, Rats, Wistar, Skin (drug effects), Skin (metabolism), Wound Healing (drug effects).
- MESH :
- chemical , chemistry : Plant Extracts.
- chemical , drug effects : Blood Glucose.
- chemical , metabolism : Alkaloids, Ascorbic Acid, Carotenoids, Collagen.
- chemistry : Citrus.
- drug effects : Body Weight, Skin, Wound Healing.
- metabolism : Diabetes Mellitus, Experimental, Skin.
- pathology : Diabetes Mellitus, Experimental.
- chemical , pharmacology : Plant Extracts.
- Administration, Oral, Animals, Male, Rats, Rats, Wistar.
Abstract
Diabetic patients wound healing is slower than the healthy individuals. Three citrus peel extracts; Lemon (Citrus limon), Grapes fruits (Citrus paradise) and Orange (Citrus sinensis) promote wound healing in experimental animals. This study investigated the effect of oral treatment with citrus peel extracts on wound repair of the skin of diabetic rats. The extracts were estimated for vitamin C and total carotenoid contents prior to animal study. Diabetes mellitus was induced in rats by intraperitoneal injection of a single dose of streptozotocin (STZ, 75 mg kg(-1) b.wt.). One week after diabetes induction, full thickness excision wounds were made in hyperglycemic rats and were divided groups, each containing 6 rats. The different test group animals were treated with different citrus peel extract orally at the dose of 400 mg kg(-1) body weight daily for 12 days. The blood glucose, body weight and rate of wound closure of each rat were measured every 3rd day during the experimental period. At the end of experiment, granular tissues of wounds were removed and estimated for hydroxylproline and total protein content. The results showed significant reduction in blood glucose and time to wound closure. Tissue growth and collagen synthesis were significantly higher as determined by total protein and hydroxyl proline content. From our experimental data, we propose that oral administration of citrus peel extracts has a therapeutic potential in the treatment of chronic wounds in diabetes.
PubMed: 24506007
Affiliations:
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Alam</name><affiliation><nlm:affiliation>Department of Pharmacognosy, College of Pharmacy, Salman Bin Abdulaziz University, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Khan, T H" sort="Khan, T H" uniqKey="Khan T" first="T H" last="Khan">T H Khan</name><affiliation><nlm:affiliation>Department of Pharmacology, College of Pharmacy, Salman Bin Abdulaziz University, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24506007</idno><idno type="pmid">24506007</idno><idno type="wicri:Area/PubMed/Corpus">000422</idno><idno type="wicri:Area/PubMed/Curation">000422</idno><idno type="wicri:Area/PubMed/Checkpoint">000422</idno><idno type="wicri:Area/Ncbi/Merge">001586</idno><idno type="wicri:Area/Ncbi/Curation">001586</idno><idno type="wicri:Area/Ncbi/Checkpoint">001586</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Oral dose of citrus peel extracts promotes wound repair in diabetic rats.</title><author><name sortKey="Ahmad, M" sort="Ahmad, M" uniqKey="Ahmad M" first="M" last="Ahmad">M. Ahmad</name><affiliation><nlm:affiliation>Department of Pharmacology, College of Pharmacy, Salman Bin Abdulaziz University, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Ansari, M N" sort="Ansari, M N" uniqKey="Ansari M" first="M N" last="Ansari">M N Ansari</name><affiliation><nlm:affiliation>Department of Pharmacology, College of Pharmacy, Salman Bin Abdulaziz University, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Alam, A" sort="Alam, A" uniqKey="Alam A" first="A" last="Alam">A. Alam</name><affiliation><nlm:affiliation>Department of Pharmacognosy, College of Pharmacy, Salman Bin Abdulaziz University, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Khan, T H" sort="Khan, T H" uniqKey="Khan T" first="T H" last="Khan">T H Khan</name><affiliation><nlm:affiliation>Department of Pharmacology, College of Pharmacy, Salman Bin Abdulaziz University, Kingdom of Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author></analytic><series><title level="j">Pakistan journal of biological sciences : PJBS</title><idno type="ISSN">1028-8880</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Alkaloids (metabolism)</term><term>Animals</term><term>Ascorbic Acid (metabolism)</term><term>Blood Glucose (drug effects)</term><term>Body Weight (drug effects)</term><term>Carotenoids (metabolism)</term><term>Citrus (chemistry)</term><term>Collagen (metabolism)</term><term>Diabetes Mellitus, Experimental (metabolism)</term><term>Diabetes Mellitus, Experimental (pathology)</term><term>Male</term><term>Plant Extracts (chemistry)</term><term>Plant Extracts (pharmacology)</term><term>Rats</term><term>Rats, Wistar</term><term>Skin (drug effects)</term><term>Skin (metabolism)</term><term>Wound Healing (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Blood Glucose</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Alkaloids</term><term>Ascorbic Acid</term><term>Carotenoids</term><term>Collagen</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Body Weight</term><term>Skin</term><term>Wound Healing</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Diabetes Mellitus, Experimental</term><term>Skin</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Diabetes Mellitus, Experimental</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Plant Extracts</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Male</term><term>Rats</term><term>Rats, Wistar</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Diabetic patients wound healing is slower than the healthy individuals. Three citrus peel extracts; Lemon (Citrus limon), Grapes fruits (Citrus paradise) and Orange (Citrus sinensis) promote wound healing in experimental animals. This study investigated the effect of oral treatment with citrus peel extracts on wound repair of the skin of diabetic rats. The extracts were estimated for vitamin C and total carotenoid contents prior to animal study. Diabetes mellitus was induced in rats by intraperitoneal injection of a single dose of streptozotocin (STZ, 75 mg kg(-1) b.wt.). One week after diabetes induction, full thickness excision wounds were made in hyperglycemic rats and were divided groups, each containing 6 rats. The different test group animals were treated with different citrus peel extract orally at the dose of 400 mg kg(-1) body weight daily for 12 days. The blood glucose, body weight and rate of wound closure of each rat were measured every 3rd day during the experimental period. At the end of experiment, granular tissues of wounds were removed and estimated for hydroxylproline and total protein content. The results showed significant reduction in blood glucose and time to wound closure. Tissue growth and collagen synthesis were significantly higher as determined by total protein and hydroxyl proline content. From our experimental data, we propose that oral administration of citrus peel extracts has a therapeutic potential in the treatment of chronic wounds in diabetes.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Ahmad, M" sort="Ahmad, M" uniqKey="Ahmad M" first="M" last="Ahmad">M. Ahmad</name><name sortKey="Alam, A" sort="Alam, A" uniqKey="Alam A" first="A" last="Alam">A. Alam</name><name sortKey="Ansari, M N" sort="Ansari, M N" uniqKey="Ansari M" first="M N" last="Ansari">M N Ansari</name><name sortKey="Khan, T H" sort="Khan, T H" uniqKey="Khan T" first="T H" last="Khan">T H Khan</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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