Application of orange essential oil as an antistaphylococcal agent in a dressing model
Identifieur interne : 001065 ( Ncbi/Checkpoint ); précédent : 001064; suivant : 001066Application of orange essential oil as an antistaphylococcal agent in a dressing model
Auteurs : Arunachalam Muthaiyan [États-Unis] ; Debabrata Biswas [États-Unis] ; Philip G. Crandall [États-Unis] ; Brian J. Wilkinson [États-Unis] ; Steven C. Ricke [États-Unis]Source :
- BMC Complementary and Alternative Medicine [ 1472-6882 ] ; 2012.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (pharmacology), Anti-Bacterial Agents (therapeutic use), Burns (drug therapy), Burns (microbiology), Cell Culture Techniques, Citrus sinensis (chemistry), Humans, Keratinocytes (drug effects), Keratinocytes (microbiology), Methicillin Resistance, Methicillin-Resistant Staphylococcus aureus (drug effects), Phytotherapy, Plant Extracts (pharmacology), Plant Extracts (therapeutic use), Plant Oils (pharmacology), Plant Oils (therapeutic use), Skin (cytology), Skin (drug effects), Skin (microbiology), Staphylococcal Infections (drug therapy), Staphylococcal Infections (microbiology), Staphylococcus aureus (drug effects), Vancomycin Resistance, Wound Healing (drug effects), Wound Infection (drug therapy), Wound Infection (microbiology).
- MESH :
- chemical , pharmacology : Anti-Bacterial Agents, Plant Extracts, Plant Oils.
- chemical , therapeutic use : Anti-Bacterial Agents, Plant Extracts, Plant Oils.
- chemistry : Citrus sinensis.
- cytology : Skin.
- drug effects : Keratinocytes, Methicillin-Resistant Staphylococcus aureus, Skin, Staphylococcus aureus, Wound Healing.
- drug therapy : Burns, Staphylococcal Infections, Wound Infection.
- microbiology : Burns, Keratinocytes, Skin, Staphylococcal Infections, Wound Infection.
- Cell Culture Techniques, Humans, Methicillin Resistance, Phytotherapy, Vancomycin Resistance.
Abstract
The inhibitory effect of CPV was determined by disc diffusion vapor assay for MRSA and vancomycin intermediate-resistant
CPV vapour effectively inhibited the MRSA and VISA strains in both disc diffusion vapour assay and
At lower concentration addition of CPV to keratinocytes infected with MRSA and VISA rapidly killed the bacterial cells without causing any toxic effect to the keratinocytes. Therefore, the results of this study warrant further in vivo study to evaluate the potential of CPV as a topical antistaphylococcal agent.
Url:
DOI: 10.1186/1472-6882-12-125
PubMed: 22894560
PubMed Central: 3522527
Affiliations:
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PMC:3522527Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Application of orange essential oil as an antistaphylococcal agent in a dressing model</title><author><name sortKey="Muthaiyan, Arunachalam" sort="Muthaiyan, Arunachalam" uniqKey="Muthaiyan A" first="Arunachalam" last="Muthaiyan">Arunachalam Muthaiyan</name><affiliation wicri:level="1"><nlm:aff id="I1">Center for Food Safety and Department of Food Science, University of Arkansas, Fayetteville, AR, 72701, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Food Safety and Department of Food Science, University of Arkansas, Fayetteville, AR, 72701</wicri:regionArea><wicri:noRegion>72701</wicri:noRegion></affiliation></author><author><name sortKey="Biswas, Debabrata" sort="Biswas, Debabrata" uniqKey="Biswas D" first="Debabrata" last="Biswas">Debabrata Biswas</name><affiliation wicri:level="1"><nlm:aff id="I1">Center for Food Safety and Department of Food Science, University of Arkansas, Fayetteville, AR, 72701, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Food Safety and Department of Food Science, University of Arkansas, Fayetteville, AR, 72701</wicri:regionArea><wicri:noRegion>72701</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="I2">Current address: Department of Animal and Avian Sciences, University of Maryland, College Park, MD, 20742, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Current address: Department of Animal and Avian Sciences, University of Maryland, College Park, MD, 20742</wicri:regionArea><orgName type="university">Université du Maryland</orgName><placeName><settlement type="city">College Park (Maryland)</settlement><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Crandall, Philip G" sort="Crandall, Philip G" uniqKey="Crandall P" first="Philip G" last="Crandall">Philip G. 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Ricke</name><affiliation wicri:level="1"><nlm:aff id="I1">Center for Food Safety and Department of Food Science, University of Arkansas, Fayetteville, AR, 72701, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Food Safety and Department of Food Science, University of Arkansas, Fayetteville, AR, 72701</wicri:regionArea><wicri:noRegion>72701</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22894560</idno><idno type="pmc">3522527</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522527</idno><idno type="RBID">PMC:3522527</idno><idno type="doi">10.1186/1472-6882-12-125</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000A94</idno><idno type="wicri:Area/Pmc/Curation">000A93</idno><idno type="wicri:Area/Pmc/Checkpoint">000D62</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000581</idno><idno type="wicri:Area/PubMed/Curation">000581</idno><idno type="wicri:Area/PubMed/Checkpoint">000581</idno><idno type="wicri:Area/Ncbi/Merge">001065</idno><idno type="wicri:Area/Ncbi/Curation">001065</idno><idno type="wicri:Area/Ncbi/Checkpoint">001065</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Application of orange essential oil as an antistaphylococcal agent in a dressing model</title><author><name sortKey="Muthaiyan, Arunachalam" sort="Muthaiyan, Arunachalam" uniqKey="Muthaiyan A" first="Arunachalam" last="Muthaiyan">Arunachalam Muthaiyan</name><affiliation wicri:level="1"><nlm:aff id="I1">Center for Food Safety and Department of Food Science, University of Arkansas, Fayetteville, AR, 72701, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Food Safety and Department of Food Science, University of Arkansas, Fayetteville, AR, 72701</wicri:regionArea><wicri:noRegion>72701</wicri:noRegion></affiliation></author><author><name sortKey="Biswas, Debabrata" sort="Biswas, Debabrata" uniqKey="Biswas D" first="Debabrata" last="Biswas">Debabrata Biswas</name><affiliation wicri:level="1"><nlm:aff id="I1">Center for Food Safety and Department of Food Science, University of Arkansas, Fayetteville, AR, 72701, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Food Safety and Department of Food Science, University of Arkansas, Fayetteville, AR, 72701</wicri:regionArea><wicri:noRegion>72701</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="I2">Current address: Department of Animal and Avian Sciences, University of Maryland, College Park, MD, 20742, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Current address: Department of Animal and Avian Sciences, University of Maryland, College Park, MD, 20742</wicri:regionArea><orgName type="university">Université du Maryland</orgName><placeName><settlement type="city">College Park (Maryland)</settlement><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Crandall, Philip G" sort="Crandall, Philip G" uniqKey="Crandall P" first="Philip G" last="Crandall">Philip G. Crandall</name><affiliation wicri:level="1"><nlm:aff id="I1">Center for Food Safety and Department of Food Science, University of Arkansas, Fayetteville, AR, 72701, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Food Safety and Department of Food Science, University of Arkansas, Fayetteville, AR, 72701</wicri:regionArea><wicri:noRegion>72701</wicri:noRegion></affiliation></author><author><name sortKey="Wilkinson, Brian J" sort="Wilkinson, Brian J" uniqKey="Wilkinson B" first="Brian J" last="Wilkinson">Brian J. Wilkinson</name><affiliation wicri:level="1"><nlm:aff id="I3">Microbiology Group, Department of Biological Sciences, Illinois State University, Normal, IL, 61790, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Microbiology Group, Department of Biological Sciences, Illinois State University, Normal, IL, 61790</wicri:regionArea><wicri:noRegion>61790</wicri:noRegion></affiliation></author><author><name sortKey="Ricke, Steven C" sort="Ricke, Steven C" uniqKey="Ricke S" first="Steven C" last="Ricke">Steven C. Ricke</name><affiliation wicri:level="1"><nlm:aff id="I1">Center for Food Safety and Department of Food Science, University of Arkansas, Fayetteville, AR, 72701, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Food Safety and Department of Food Science, University of Arkansas, Fayetteville, AR, 72701</wicri:regionArea><wicri:noRegion>72701</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Complementary and Alternative Medicine</title><idno type="eISSN">1472-6882</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Bacterial Agents (pharmacology)</term><term>Anti-Bacterial Agents (therapeutic use)</term><term>Burns (drug therapy)</term><term>Burns (microbiology)</term><term>Cell Culture Techniques</term><term>Citrus sinensis (chemistry)</term><term>Humans</term><term>Keratinocytes (drug effects)</term><term>Keratinocytes (microbiology)</term><term>Methicillin Resistance</term><term>Methicillin-Resistant Staphylococcus aureus (drug effects)</term><term>Phytotherapy</term><term>Plant Extracts (pharmacology)</term><term>Plant Extracts (therapeutic use)</term><term>Plant Oils (pharmacology)</term><term>Plant Oils (therapeutic use)</term><term>Skin (cytology)</term><term>Skin (drug effects)</term><term>Skin (microbiology)</term><term>Staphylococcal Infections (drug therapy)</term><term>Staphylococcal Infections (microbiology)</term><term>Staphylococcus aureus (drug effects)</term><term>Vancomycin Resistance</term><term>Wound Healing (drug effects)</term><term>Wound Infection (drug therapy)</term><term>Wound Infection (microbiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Plant Extracts</term><term>Plant Oils</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Plant Extracts</term><term>Plant Oils</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Skin</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Keratinocytes</term><term>Methicillin-Resistant Staphylococcus aureus</term><term>Skin</term><term>Staphylococcus aureus</term><term>Wound Healing</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Burns</term><term>Staphylococcal Infections</term><term>Wound Infection</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Burns</term><term>Keratinocytes</term><term>Skin</term><term>Staphylococcal Infections</term><term>Wound Infection</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Culture Techniques</term><term>Humans</term><term>Methicillin Resistance</term><term>Phytotherapy</term><term>Vancomycin Resistance</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p><italic>Staphylococcus aureus</italic> is the pathogen most often and prevalently involved in skin and soft tissue infections. In recent decades outbreaks of methicillin-resistant <italic>S. aureus</italic> (MRSA) have created major problems for skin therapy, and burn and wound care units. Topical antimicrobials are most important component of wound infection therapy. Alternative therapies are being sought for treatment of MRSA and one area of interest is the use of essential oils. With the increasing interest in the use and application of natural products, we screened the potential application of terpeneless cold pressed Valencia orange oil (CPV) for topical therapy against MRSA using an <italic>in vitro</italic> dressing model and skin keratinocyte cell culture model.</p></sec><sec><title>Methods</title><p>The inhibitory effect of CPV was determined by disc diffusion vapor assay for MRSA and vancomycin intermediate-resistant <italic>S. aureus</italic> (VISA) strains. Antistaphylococcal effect of CPV in an <italic>in vitro</italic> dressing model was tested on <italic>S. aureus</italic> inoculated tryptic soya agar plate. Bactericidal effect of CPV on MRSA and VISA infected keratinocyte cells was examined by enumeration of extra- and intra-cellular bacterial cells at different treatment time points. Cytotoxic effects on human skin cells was tested by adding CPV to the keratinocyte (HEK001) cells grown in serum free KSFM media, and observed by phase-contrast microscope.</p></sec><sec><title>Results</title><p>CPV vapour effectively inhibited the MRSA and VISA strains in both disc diffusion vapour assay and <italic>in vitro</italic> dressing model. Compared to untreated control addition of 0.1% CPV to MRSA infected keratinocyte decreased the viable MRSA cells by 2 log CFU/mL in 1 h and in VISA strain 3 log CFU/mL reduction was observed in 1 h. After 3 h viable <italic>S. aureus</italic> cells were not detected in the 0.2% CPV treatment. Bactericidal concentration of CPV did not show any cytotoxic effect on the human skin keratinocyte cells <italic>in vitro</italic>.</p></sec><sec><title>Conclusions</title><p>At lower concentration addition of CPV to keratinocytes infected with MRSA and VISA rapidly killed the bacterial cells without causing any toxic effect to the keratinocytes. Therefore, the results of this study warrant further in vivo study to evaluate the potential of CPV as a topical antistaphylococcal agent.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Otto, M" uniqKey="Otto M">M Otto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Ae" uniqKey="Chen A">AE Chen</name></author><author><name sortKey="Goldstein, M" uniqKey="Goldstein M">M Goldstein</name></author><author><name sortKey="Carroll, K" uniqKey="Carroll K">K Carroll</name></author><author><name sortKey="Song, X" uniqKey="Song X">X Song</name></author><author><name sortKey="Perl, Tm" uniqKey="Perl T">TM Perl</name></author><author><name sortKey="Siberry, Gk" uniqKey="Siberry G">GK Siberry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hersh, Al" uniqKey="Hersh A">AL Hersh</name></author><author><name sortKey="Chambers, Hf" uniqKey="Chambers H">HF 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Laxminarayan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mera, Rm" uniqKey="Mera R">RM Mera</name></author><author><name sortKey="Suaya, Ja" uniqKey="Suaya J">JA Suaya</name></author><author><name sortKey="Amrine Madsen, H" uniqKey="Amrine Madsen H">H Amrine-Madsen</name></author><author><name sortKey="Hogea, Cs" uniqKey="Hogea C">CS Hogea</name></author><author><name sortKey="Miller, La" uniqKey="Miller L">LA Miller</name></author><author><name sortKey="Lu, Ep" uniqKey="Lu E">EP Lu</name></author><author><name sortKey="Sahm, Df" uniqKey="Sahm D">DF Sahm</name></author><author><name sortKey="O Hara, P" uniqKey="O Hara P">P O'Hara</name></author><author><name sortKey="Acosta, Cj" uniqKey="Acosta C">CJ Acosta</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region><settlement><li>College Park (Maryland)</li></settlement><orgName><li>Université du Maryland</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Muthaiyan, Arunachalam" sort="Muthaiyan, Arunachalam" uniqKey="Muthaiyan A" first="Arunachalam" last="Muthaiyan">Arunachalam Muthaiyan</name></noRegion><name sortKey="Biswas, Debabrata" sort="Biswas, Debabrata" uniqKey="Biswas D" first="Debabrata" last="Biswas">Debabrata Biswas</name><name sortKey="Biswas, Debabrata" sort="Biswas, Debabrata" uniqKey="Biswas D" first="Debabrata" last="Biswas">Debabrata Biswas</name><name sortKey="Crandall, Philip G" sort="Crandall, Philip G" uniqKey="Crandall P" first="Philip G" last="Crandall">Philip G. Crandall</name><name sortKey="Ricke, Steven C" sort="Ricke, Steven C" uniqKey="Ricke S" first="Steven C" last="Ricke">Steven C. Ricke</name><name sortKey="Wilkinson, Brian J" sort="Wilkinson, Brian J" uniqKey="Wilkinson B" first="Brian J" last="Wilkinson">Brian J. Wilkinson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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