Determination of bitter orange alkaloids in dietary supplement Standard Reference Materials by liquid chromatography with atmospheric-pressure ionization mass spectrometry.
Identifieur interne : 002398 ( Main/Merge ); précédent : 002397; suivant : 002399Determination of bitter orange alkaloids in dietary supplement Standard Reference Materials by liquid chromatography with atmospheric-pressure ionization mass spectrometry.
Auteurs : Karsten Putzbach [Suisse] ; Catherine A. Rimmer ; Katherine E. Sharpless ; Stephen A. Wise ; Lane C. SanderSource :
- Analytical and bioanalytical chemistry [ 1618-2642 ] ; 2007.
English descriptors
- KwdEn :
- Alkaloids (analysis), Alkaloids (chemistry), Biological Products (chemistry), Chromatography, Liquid (methods), Citrus sinensis (chemistry), Dietary Supplements (analysis), Dietary Supplements (standards), Molecular Structure, Plant Extracts (chemistry), Pressure, Reference Standards, Sonication, Spectrometry, Mass, Electrospray Ionization (methods).
- MESH :
- chemical , analysis : Alkaloids.
- chemical , chemistry : Alkaloids, Biological Products, Plant Extracts.
- analysis : Dietary Supplements.
- chemistry : Citrus sinensis.
- methods : Chromatography, Liquid, Spectrometry, Mass, Electrospray Ionization.
- standards : Dietary Supplements.
- Molecular Structure, Pressure, Reference Standards, Sonication.
Abstract
A liquid chromatographic atmospheric-pressure ionization electrospray mass spectrometry (LC-API-ES-MS) method has been developed for the determination of five bitter orange alkaloids (synephrine, octopamine, n-methyltyramine, tyramine, and hordenine) in bitter orange-containing dietary supplement standard reference materials (SRMs). The materials represent a variety of natural, extracted, and processed sample matrices. Two extraction techniques were evaluated: pressurized-fluid extraction (PFE) and sonication extraction. The influence of different solvents, extraction temperatures, and pH were investigated for a plant material and a processed sample. The LC method uses a new approach for the separation of highly polar alkaloids. A fluorinated, silica-based stationary phase separated the five alkaloids and the internal standard terbutaline in less than 20 min. This method enabled the determination of the dominant alkaloid synephrine and other minor alkaloids in a variety of dietary supplement SRMs.
DOI: 10.1007/s00216-007-1409-6
PubMed: 17579842
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pubmed:17579842Le document en format XML
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Sharpless</name></author><author><name sortKey="Wise, Stephen A" sort="Wise, Stephen A" uniqKey="Wise S" first="Stephen A" last="Wise">Stephen A. Wise</name></author><author><name sortKey="Sander, Lane C" sort="Sander, Lane C" uniqKey="Sander L" first="Lane C" last="Sander">Lane C. Sander</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17579842</idno><idno type="pmid">17579842</idno><idno type="doi">10.1007/s00216-007-1409-6</idno><idno type="wicri:Area/PubMed/Corpus">000B09</idno><idno type="wicri:Area/PubMed/Curation">000B09</idno><idno type="wicri:Area/PubMed/Checkpoint">000B09</idno><idno type="wicri:Area/Ncbi/Merge">000713</idno><idno type="wicri:Area/Ncbi/Curation">000713</idno><idno type="wicri:Area/Ncbi/Checkpoint">000713</idno><idno type="wicri:doubleKey">1618-2642:2007:Putzbach K:determination:of:bitter</idno><idno type="wicri:Area/Main/Merge">002398</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Determination of bitter orange alkaloids in dietary supplement Standard Reference Materials by liquid chromatography with atmospheric-pressure ionization mass spectrometry.</title><author><name sortKey="Putzbach, Karsten" sort="Putzbach, Karsten" uniqKey="Putzbach K" first="Karsten" last="Putzbach">Karsten Putzbach</name><affiliation wicri:level="1"><nlm:affiliation>RCC Ltd., Zelgliweg 1, CH-4452, Itingen, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>RCC Ltd., Zelgliweg 1, CH-4452, Itingen</wicri:regionArea><wicri:noRegion>Itingen</wicri:noRegion></affiliation></author><author><name sortKey="Rimmer, Catherine A" sort="Rimmer, Catherine A" uniqKey="Rimmer C" first="Catherine A" last="Rimmer">Catherine A. Rimmer</name></author><author><name sortKey="Sharpless, Katherine E" sort="Sharpless, Katherine E" uniqKey="Sharpless K" first="Katherine E" last="Sharpless">Katherine E. Sharpless</name></author><author><name sortKey="Wise, Stephen A" sort="Wise, Stephen A" uniqKey="Wise S" first="Stephen A" last="Wise">Stephen A. Wise</name></author><author><name sortKey="Sander, Lane C" sort="Sander, Lane C" uniqKey="Sander L" first="Lane C" last="Sander">Lane C. Sander</name></author></analytic><series><title level="j">Analytical and bioanalytical chemistry</title><idno type="ISSN">1618-2642</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alkaloids (analysis)</term><term>Alkaloids (chemistry)</term><term>Biological Products (chemistry)</term><term>Chromatography, Liquid (methods)</term><term>Citrus sinensis (chemistry)</term><term>Dietary Supplements (analysis)</term><term>Dietary Supplements (standards)</term><term>Molecular Structure</term><term>Plant Extracts (chemistry)</term><term>Pressure</term><term>Reference Standards</term><term>Sonication</term><term>Spectrometry, Mass, Electrospray Ionization (methods)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Alkaloids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Alkaloids</term><term>Biological Products</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Dietary Supplements</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chromatography, Liquid</term><term>Spectrometry, Mass, Electrospray Ionization</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Dietary Supplements</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Molecular Structure</term><term>Pressure</term><term>Reference Standards</term><term>Sonication</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A liquid chromatographic atmospheric-pressure ionization electrospray mass spectrometry (LC-API-ES-MS) method has been developed for the determination of five bitter orange alkaloids (synephrine, octopamine, n-methyltyramine, tyramine, and hordenine) in bitter orange-containing dietary supplement standard reference materials (SRMs). The materials represent a variety of natural, extracted, and processed sample matrices. Two extraction techniques were evaluated: pressurized-fluid extraction (PFE) and sonication extraction. The influence of different solvents, extraction temperatures, and pH were investigated for a plant material and a processed sample. The LC method uses a new approach for the separation of highly polar alkaloids. A fluorinated, silica-based stationary phase separated the five alkaloids and the internal standard terbutaline in less than 20 min. This method enabled the determination of the dominant alkaloid synephrine and other minor alkaloids in a variety of dietary supplement SRMs.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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