Protective effects of a red orange extract on UVB-induced damage in human keratinocytes.
Identifieur interne : 002350 ( Main/Merge ); précédent : 002349; suivant : 002351Protective effects of a red orange extract on UVB-induced damage in human keratinocytes.
Auteurs : Francesco Cimino [Italie] ; Mariateresa Cristani ; Antonina Saija ; Franco Paolo Bonina ; Fabio VirgiliSource :
- BioFactors (Oxford, England) [ 0951-6433 ] ; 2007.
English descriptors
- KwdEn :
- Anthocyanins (analysis), Apoptosis (drug effects), Ascorbic Acid (analysis), Blotting, Western, Cell Line, Transformed, Citrus sinensis (chemistry), Coumaric Acids (analysis), Electrophoretic Mobility Shift Assay, Flavanones (analysis), Fruit (chemistry), Humans, Inflammation (prevention & control), Keratinocytes (drug effects), Keratinocytes (radiation effects), Phytotherapy, Plant Extracts (chemistry), Plant Extracts (pharmacology), Ultraviolet Rays (adverse effects).
- MESH :
- chemical , analysis : Anthocyanins, Ascorbic Acid, Coumaric Acids, Flavanones.
- adverse effects : Ultraviolet Rays.
- chemistry : Citrus sinensis, Fruit, Plant Extracts.
- drug effects : Apoptosis, Keratinocytes.
- chemical , pharmacology : Plant Extracts.
- prevention & control : Inflammation.
- radiation effects : Keratinocytes.
- Blotting, Western, Cell Line, Transformed, Electrophoretic Mobility Shift Assay, Humans, Phytotherapy.
Abstract
UV light is considered one of the major etiological factor in skin aging, cancer and also to systemic impairment such as immunosuppression. Increased production of reactive oxygen species (ROS) and oxidative stress condition are known to play a central role in initiating and driving the signalling events that lead to cellular response following UV irradiation. In the present study we have investigated the photoprotective activity of a standardized extract from red orange (ROE), obtained from three red orange varieties and containing as main active principles phenolic compounds (anthocyanins, flavanones and hydroxycinnamic acids) and ascorbic acid. The aim of this study was to evaluate the efficacy of ROE in modulating cellular responses to UVB in human keratinocytes (HaCaT). Our data indicate that ROE is potentially able to efficiently counteract UVB-induced response, and in particular some events associated to inflammation and apoptosis, such as NF-kB and AP-1 translocation and procaspase-3 cleavage. This activity is probably due to a block of cellular oxidative stress-related events. Thus we can propose ROE as a useful natural standardised extract in skin photoprotection with promising applications in the field of dermatology.
PubMed: 18356584
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sortKey="Bonina, Franco Paolo" sort="Bonina, Franco Paolo" uniqKey="Bonina F" first="Franco Paolo" last="Bonina">Franco Paolo Bonina</name></author><author><name sortKey="Virgili, Fabio" sort="Virgili, Fabio" uniqKey="Virgili F" first="Fabio" last="Virgili">Fabio Virgili</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:18356584</idno><idno type="pmid">18356584</idno><idno type="wicri:Area/PubMed/Corpus">000B70</idno><idno type="wicri:Area/PubMed/Curation">000B70</idno><idno type="wicri:Area/PubMed/Checkpoint">000B70</idno><idno type="wicri:Area/Ncbi/Merge">000809</idno><idno type="wicri:Area/Ncbi/Curation">000809</idno><idno type="wicri:Area/Ncbi/Checkpoint">000809</idno><idno type="wicri:doubleKey">0951-6433:2007:Cimino F:protective:effects:of</idno><idno type="wicri:Area/Main/Merge">002350</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Protective effects of a red orange extract on UVB-induced damage in human keratinocytes.</title><author><name sortKey="Cimino, Francesco" sort="Cimino, Francesco" uniqKey="Cimino F" first="Francesco" last="Cimino">Francesco Cimino</name><affiliation wicri:level="1"><nlm:affiliation>Department of Farmaco-Biologico, University of Messina, Messina, Italy. fcimino@pharma.unime.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Farmaco-Biologico, University of Messina, Messina</wicri:regionArea><wicri:noRegion>Messina</wicri:noRegion></affiliation></author><author><name sortKey="Cristani, Mariateresa" sort="Cristani, Mariateresa" uniqKey="Cristani M" first="Mariateresa" last="Cristani">Mariateresa Cristani</name></author><author><name sortKey="Saija, Antonina" sort="Saija, Antonina" uniqKey="Saija A" first="Antonina" last="Saija">Antonina Saija</name></author><author><name sortKey="Bonina, Franco Paolo" sort="Bonina, Franco Paolo" uniqKey="Bonina F" first="Franco Paolo" last="Bonina">Franco Paolo Bonina</name></author><author><name sortKey="Virgili, Fabio" sort="Virgili, Fabio" uniqKey="Virgili F" first="Fabio" last="Virgili">Fabio Virgili</name></author></analytic><series><title level="j">BioFactors (Oxford, England)</title><idno type="ISSN">0951-6433</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anthocyanins (analysis)</term><term>Apoptosis (drug effects)</term><term>Ascorbic Acid (analysis)</term><term>Blotting, Western</term><term>Cell Line, Transformed</term><term>Citrus sinensis (chemistry)</term><term>Coumaric Acids (analysis)</term><term>Electrophoretic Mobility Shift Assay</term><term>Flavanones (analysis)</term><term>Fruit (chemistry)</term><term>Humans</term><term>Inflammation (prevention & control)</term><term>Keratinocytes (drug effects)</term><term>Keratinocytes (radiation effects)</term><term>Phytotherapy</term><term>Plant Extracts (chemistry)</term><term>Plant Extracts (pharmacology)</term><term>Ultraviolet Rays (adverse effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Anthocyanins</term><term>Ascorbic Acid</term><term>Coumaric Acids</term><term>Flavanones</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Ultraviolet Rays</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term><term>Fruit</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Keratinocytes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Keratinocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Blotting, Western</term><term>Cell Line, Transformed</term><term>Electrophoretic Mobility Shift Assay</term><term>Humans</term><term>Phytotherapy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">UV light is considered one of the major etiological factor in skin aging, cancer and also to systemic impairment such as immunosuppression. Increased production of reactive oxygen species (ROS) and oxidative stress condition are known to play a central role in initiating and driving the signalling events that lead to cellular response following UV irradiation. In the present study we have investigated the photoprotective activity of a standardized extract from red orange (ROE), obtained from three red orange varieties and containing as main active principles phenolic compounds (anthocyanins, flavanones and hydroxycinnamic acids) and ascorbic acid. The aim of this study was to evaluate the efficacy of ROE in modulating cellular responses to UVB in human keratinocytes (HaCaT). Our data indicate that ROE is potentially able to efficiently counteract UVB-induced response, and in particular some events associated to inflammation and apoptosis, such as NF-kB and AP-1 translocation and procaspase-3 cleavage. This activity is probably due to a block of cellular oxidative stress-related events. Thus we can propose ROE as a useful natural standardised extract in skin photoprotection with promising applications in the field of dermatology.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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