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Stereospecific analysis of sakuranetin by high-performance liquid chromatography: pharmacokinetic and botanical applications.

Identifieur interne : 002065 ( Main/Merge ); précédent : 002064; suivant : 002066

Stereospecific analysis of sakuranetin by high-performance liquid chromatography: pharmacokinetic and botanical applications.

Auteurs : Jody K. Takemoto [États-Unis] ; Connie M. Remsberg ; Jaime A. Yá Ez ; Karina R. Vega-Villa ; Neal M. Davies

Source :

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [ 1570-0232 ] ; 2008.

RBID : pubmed:18676186

English descriptors

KwdEn :
- Animals, Chromatography, High Pressure Liquid (methods), Citrus sinensis (chemistry), Flavonoids (analysis), Flavonoids (pharmacokinetics), Male, Rats, Rats, Sprague-Dawley, Reproducibility of Results, Stereoisomerism, Uncertainty.
MESH :
- chemical , analysis : Flavonoids.
- chemistry : Citrus sinensis.
- methods : Chromatography, High Pressure Liquid.
- chemical , pharmacokinetics : Flavonoids.
- Animals, Male, Rats, Rats, Sprague-Dawley, Reproducibility of Results, Stereoisomerism, Uncertainty.

Abstract

A stereospecific method for analysis of sakuranetin was developed. Separation was accomplished using a Chiralpak AD-RH column with UV (ultraviolet) detection at 288 nm. The stereospecific linear calibration curves ranged from 0.5 to 100 microg/mL. The mean extraction efficiency was >98%. Precision of the assay was <12% (relative standard deviation (R.S.D.)%), and within 10% at the limit of quantitation (0.5 microg/mL). Bias of the assay was lower than 10%, and within 5% at the limit of quantitation. The assay was applied successfully to pharmacokinetic quantification in rats, and the stereospecific quantification in oranges, grapefruit juice, and matico (Piper aduncum L.).

DOI: 10.1016/j.jchromb.2008.07.019
PubMed: 18676186

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pubmed:18676186

Le document en format XML

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<affiliation wicri:level="2"><nlm:affiliation>College of Pharmacy, Department of Pharmaceutical Sciences and Pharmacology and Toxicology Graduate Program, Washington State University, Pullman, WA 99164-6534, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>College of Pharmacy, Department of Pharmaceutical Sciences and Pharmacology and Toxicology Graduate Program, Washington State University, Pullman, WA 99164-6534</wicri:regionArea>
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<author><name sortKey="Remsberg, Connie M" sort="Remsberg, Connie M" uniqKey="Remsberg C" first="Connie M" last="Remsberg">Connie M. Remsberg</name>
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<author><name sortKey="Ya Ez, Jaime A" sort="Ya Ez, Jaime A" uniqKey="Ya Ez J" first="Jaime A" last="Yá Ez">Jaime A. Yá Ez</name>
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<author><name sortKey="Vega Villa, Karina R" sort="Vega Villa, Karina R" uniqKey="Vega Villa K" first="Karina R" last="Vega-Villa">Karina R. Vega-Villa</name>
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<author><name sortKey="Davies, Neal M" sort="Davies, Neal M" uniqKey="Davies N" first="Neal M" last="Davies">Neal M. Davies</name>
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<author><name sortKey="Ya Ez, Jaime A" sort="Ya Ez, Jaime A" uniqKey="Ya Ez J" first="Jaime A" last="Yá Ez">Jaime A. Yá Ez</name>
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<author><name sortKey="Vega Villa, Karina R" sort="Vega Villa, Karina R" uniqKey="Vega Villa K" first="Karina R" last="Vega-Villa">Karina R. Vega-Villa</name>
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<author><name sortKey="Davies, Neal M" sort="Davies, Neal M" uniqKey="Davies N" first="Neal M" last="Davies">Neal M. Davies</name>
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<term>Citrus sinensis (chemistry)</term>
<term>Flavonoids (analysis)</term>
<term>Flavonoids (pharmacokinetics)</term>
<term>Male</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
<term>Reproducibility of Results</term>
<term>Stereoisomerism</term>
<term>Uncertainty</term>
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<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Flavonoids</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chromatography, High Pressure Liquid</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Flavonoids</term>
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<term>Male</term>
<term>Rats</term>
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<front><div type="abstract" xml:lang="en">A stereospecific method for analysis of sakuranetin was developed. Separation was accomplished using a Chiralpak AD-RH column with UV (ultraviolet) detection at 288 nm. The stereospecific linear calibration curves ranged from 0.5 to 100 microg/mL. The mean extraction efficiency was >98%. Precision of the assay was <12% (relative standard deviation (R.S.D.)%), and within 10% at the limit of quantitation (0.5 microg/mL). Bias of the assay was lower than 10%, and within 5% at the limit of quantitation. The assay was applied successfully to pharmacokinetic quantification in rats, and the stereospecific quantification in oranges, grapefruit juice, and matico (Piper aduncum L.).</div>
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Stereospecific analysis of sakuranetin by high-performance liquid chromatography: pharmacokinetic and botanical applications.

Stereospecific analysis of sakuranetin by high-performance liquid chromatography: pharmacokinetic and botanical applications.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki