Metallomics: An integrated science for metals in biology and medicine
Identifieur interne : 001B75 ( Main/Merge ); précédent : 001B74; suivant : 001B76Metallomics: An integrated science for metals in biology and medicine
Auteurs : Hongzhe Sun [République populaire de Chine, Hong Kong] ; Zhi-Fang Chai [République populaire de Chine]Source :
- Annual Reports Section "A" (Inorganic Chemistry) [ 0260-1818 ] ; 2010.
Abstract
Metallomics and metalloproteomics are an emerging scientific area focusing on the molecular mechanisms of metal-dependent life processes and the entirety of metal and metalloid species within a cell or tissue/organ. Metallomics is also a part of functional proteomics, complements metabonomics and structural geonomics of metalloproteins. This review summarizes the recent progress of metallomics with a focus on analytical techniques capable of high-throughput quantification, distribution, speciation, identification and structural characterisation. The applications of these advanced analytical methods in the identification of metallo-/phosphor-/seleno-proteins, probing of structure-function relationships of metalloproteins, and the study of metallodrugs will be selectively outlined.
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DOI: 10.1039/b920672h
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<front><div type="abstract">Metallomics and metalloproteomics are an emerging scientific area focusing on the molecular mechanisms of metal-dependent life processes and the entirety of metal and metalloid species within a cell or tissue/organ. Metallomics is also a part of functional proteomics, complements metabonomics and structural geonomics of metalloproteins. This review summarizes the recent progress of metallomics with a focus on analytical techniques capable of high-throughput quantification, distribution, speciation, identification and structural characterisation. The applications of these advanced analytical methods in the identification of metallo-/phosphor-/seleno-proteins, probing of structure-function relationships of metalloproteins, and the study of metallodrugs will be selectively outlined.</div>
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