Fruit Juices as Perpetrators of Drug Interactions: The Role of Organic Anion–Transporting Polypeptides
Identifieur interne : 001509 ( Main/Merge ); précédent : 001508; suivant : 001510Fruit Juices as Perpetrators of Drug Interactions: The Role of Organic Anion–Transporting Polypeptides
Auteurs : M J Dolton [Australie] ; B D Roufogalis [Australie] ; A J Mclachlan [Australie]Source :
- Clinical Pharmacology & Therapeutics [ 0009-9236 ] ; 2012-11.
Abstract
Grapefruit juice is widely recognized to cause important drug interactions via inhibition of CYP3A4, and a wider variety of fruit juices have been shown to inhibit influx transporters in enterocytes known as organic anion–transporting polypeptides (OATPs). Fruit juice coadministration significantly reduces the oral bioavailability of numerous important medicines relying on this anion transporter pathway for absorption. This article reviews the current literature on interactions between clinically used OATP substrates and fruit juice consumption.
Url:
DOI: 10.1038/clpt.2012.159
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