Structure-activity relationship of citrus polymethoxylated flavones and their inhibitory effects on Aspergillus niger.
Identifieur interne : 001204 ( Main/Merge ); précédent : 001203; suivant : 001205Structure-activity relationship of citrus polymethoxylated flavones and their inhibitory effects on Aspergillus niger.
Auteurs : Li Liu [République populaire de Chine] ; Xiaoyun Xu ; Dan Cheng ; Xiaolin Yao ; Siyi PanSource :
- Journal of agricultural and food chemistry [ 1520-5118 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Flavones.
- chemistry : Citrus, Fruit.
- drug effects : Aspergillus niger.
- chemical , pharmacology : Flavones, Fungicides, Industrial.
- Food Microbiology, Food Preservatives, Microbial Sensitivity Tests, Molecular Structure, Structure-Activity Relationship.
Abstract
Citrus peels are rich in polymethoxylated flavones (PMFs) and are potential sources of natural preservatives. Six PMFs extracts, isolated and purified from the peels of three mandarins (Citrus reticulata) and three sweet oranges (Citrus sinensis), were identified and quantitated. Their inhibitory effects on Aspergillus niger were evaluated using a microbroth dilution assay. The Red tangerine variety exhibited the greatest antifungal activity (MIC = 0.2 mg/mL), while Jincheng showed the lowest activity (MIC = 1.8 mg/mL). An analysis of principal components was applied to the results in order to elucidate the structure-activity relationships of the citrus PMFs. The structure-activity relationship analysis revealed that, for good inhibitory effect, the 5-OH, 3-OCH₃, and 8-OCH₃ functionalities were essential, while the presence of 3-OH and 3'-OCH₃ greatly reduced inhibition. The findings of this study provide important information for the exploitation and utilization of citrus PMFs as natural biopreservatives.
DOI: 10.1021/jf3012163
PubMed: 22500738
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000609
- to stream PubMed, to step Curation: 000609
- to stream PubMed, to step Checkpoint: 000609
- to stream Ncbi, to step Merge: 000F71
- to stream Ncbi, to step Curation: 000F71
- to stream Ncbi, to step Checkpoint: 000F71
Links to Exploration step
pubmed:22500738Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Structure-activity relationship of citrus polymethoxylated flavones and their inhibitory effects on Aspergillus niger.</title><author><name sortKey="Liu, Li" sort="Liu, Li" uniqKey="Liu L" first="Li" last="Liu">Li Liu</name><affiliation wicri:level="1"><nlm:affiliation>College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070</wicri:regionArea><wicri:noRegion>Hubei 430070</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Xiaoyun" sort="Xu, Xiaoyun" uniqKey="Xu X" first="Xiaoyun" last="Xu">Xiaoyun Xu</name></author><author><name sortKey="Cheng, Dan" sort="Cheng, Dan" uniqKey="Cheng D" first="Dan" last="Cheng">Dan Cheng</name></author><author><name sortKey="Yao, Xiaolin" sort="Yao, Xiaolin" uniqKey="Yao X" first="Xiaolin" last="Yao">Xiaolin Yao</name></author><author><name sortKey="Pan, Siyi" sort="Pan, Siyi" uniqKey="Pan S" first="Siyi" last="Pan">Siyi Pan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22500738</idno><idno type="pmid">22500738</idno><idno type="doi">10.1021/jf3012163</idno><idno type="wicri:Area/PubMed/Corpus">000609</idno><idno type="wicri:Area/PubMed/Curation">000609</idno><idno type="wicri:Area/PubMed/Checkpoint">000609</idno><idno type="wicri:Area/Ncbi/Merge">000F71</idno><idno type="wicri:Area/Ncbi/Curation">000F71</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F71</idno><idno type="wicri:Area/Main/Merge">001204</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Structure-activity relationship of citrus polymethoxylated flavones and their inhibitory effects on Aspergillus niger.</title><author><name sortKey="Liu, Li" sort="Liu, Li" uniqKey="Liu L" first="Li" last="Liu">Li Liu</name><affiliation wicri:level="1"><nlm:affiliation>College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070</wicri:regionArea><wicri:noRegion>Hubei 430070</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Xiaoyun" sort="Xu, Xiaoyun" uniqKey="Xu X" first="Xiaoyun" last="Xu">Xiaoyun Xu</name></author><author><name sortKey="Cheng, Dan" sort="Cheng, Dan" uniqKey="Cheng D" first="Dan" last="Cheng">Dan Cheng</name></author><author><name sortKey="Yao, Xiaolin" sort="Yao, Xiaolin" uniqKey="Yao X" first="Xiaolin" last="Yao">Xiaolin Yao</name></author><author><name sortKey="Pan, Siyi" sort="Pan, Siyi" uniqKey="Pan S" first="Siyi" last="Pan">Siyi Pan</name></author></analytic><series><title level="j">Journal of agricultural and food chemistry</title><idno type="eISSN">1520-5118</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aspergillus niger (drug effects)</term><term>Citrus (chemistry)</term><term>Flavones (chemistry)</term><term>Flavones (pharmacology)</term><term>Food Microbiology</term><term>Food Preservatives</term><term>Fruit (chemistry)</term><term>Fungicides, Industrial (pharmacology)</term><term>Microbial Sensitivity Tests</term><term>Molecular Structure</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Flavones</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus</term><term>Fruit</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Aspergillus niger</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Flavones</term><term>Fungicides, Industrial</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Food Microbiology</term><term>Food Preservatives</term><term>Microbial Sensitivity Tests</term><term>Molecular Structure</term><term>Structure-Activity Relationship</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Citrus peels are rich in polymethoxylated flavones (PMFs) and are potential sources of natural preservatives. Six PMFs extracts, isolated and purified from the peels of three mandarins (Citrus reticulata) and three sweet oranges (Citrus sinensis), were identified and quantitated. Their inhibitory effects on Aspergillus niger were evaluated using a microbroth dilution assay. The Red tangerine variety exhibited the greatest antifungal activity (MIC = 0.2 mg/mL), while Jincheng showed the lowest activity (MIC = 1.8 mg/mL). An analysis of principal components was applied to the results in order to elucidate the structure-activity relationships of the citrus PMFs. The structure-activity relationship analysis revealed that, for good inhibitory effect, the 5-OH, 3-OCH₃, and 8-OCH₃ functionalities were essential, while the presence of 3-OH and 3'-OCH₃ greatly reduced inhibition. The findings of this study provide important information for the exploitation and utilization of citrus PMFs as natural biopreservatives.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/OrangerV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001204 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001204 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Bois
|area= OrangerV1
|flux= Main
|étape= Merge
|type= RBID
|clé= pubmed:22500738
|texte= Structure-activity relationship of citrus polymethoxylated flavones and their inhibitory effects on Aspergillus niger.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:22500738" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a OrangerV1
| This area was generated with Dilib version V0.6.25. |  |