Effect of orange juice and beverage with phytosterols on cytokines and PAI-1 activity.
Identifieur interne : 001747 ( Main/Exploration ); précédent : 001746; suivant : 001748Effect of orange juice and beverage with phytosterols on cytokines and PAI-1 activity.
Auteurs : Sridevi Devaraj [États-Unis] ; Ishwarlal Jialal ; Jason Rockwood ; Danielle ZakSource :
- Clinical nutrition (Edinburgh, Scotland) [ 1532-1983 ] ; 2011.
English descriptors
- KwdEn :
- Adult, Aged, Beverages (analysis), Biomarkers (blood), Citrus sinensis (chemistry), Dietary Supplements (analysis), Double-Blind Method, Down-Regulation, Female, Fibrinolysis, Fruit (chemistry), Humans, Interleukin-1beta (blood), Interleukin-6 (blood), Male, Middle Aged, Phytosterols (administration & dosage), Plasminogen Activator Inhibitor 1 (blood), Retrospective Studies, Young Adult.
- MESH :
- chemical , administration & dosage : Phytosterols.
- chemical , blood : Biomarkers, Interleukin-1beta, Interleukin-6, Plasminogen Activator Inhibitor 1.
- analysis : Beverages, Dietary Supplements.
- chemistry : Citrus sinensis, Fruit.
- Adult, Aged, Double-Blind Method, Down-Regulation, Female, Fibrinolysis, Humans, Male, Middle Aged, Retrospective Studies, Young Adult.
Abstract
Inflammation is pivotal in all phases of atherosclerosis. Dietary options which lower inflammatory biomarkers would be an attractive strategy to reduce risk from cardiovascular diseases and cancer. Indeed, fruit and vegetable intake or fruit juice consumption is associated with health and wellness. However, there is a paucity of data examining the effect of orange juice on biomarkers of inflammation in healthy volunteers. We have previously conducted the first placebo-controlled randomized studies examining the effect of sterol fortified orange juice or sterol fortified reduced calorie orange juice beverage supplementation (2 g sterols/day) compared to Placebo OJ or Placebo OJBev, and showed significant benefits on the lipid profile as well as significant reduction in hsCRP, the prototypic marker of inflammation and a cardiovascular risk marker. The aim of this study was to examine the effect of orange juice (OJ) or OJ beverage (Bev) alone and fortified with plant sterols (1g/240 ml juice or beverage twice a day) on pro-inflammatory cytokines and PAI-1, a marker of impaired fibrinolysis in healthy human volunteers.
DOI: 10.1016/j.clnu.2011.03.009
PubMed: 21477901
Affiliations:
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Le document en format XML
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Dietary options which lower inflammatory biomarkers would be an attractive strategy to reduce risk from cardiovascular diseases and cancer. Indeed, fruit and vegetable intake or fruit juice consumption is associated with health and wellness. However, there is a paucity of data examining the effect of orange juice on biomarkers of inflammation in healthy volunteers. We have previously conducted the first placebo-controlled randomized studies examining the effect of sterol fortified orange juice or sterol fortified reduced calorie orange juice beverage supplementation (2 g sterols/day) compared to Placebo OJ or Placebo OJBev, and showed significant benefits on the lipid profile as well as significant reduction in hsCRP, the prototypic marker of inflammation and a cardiovascular risk marker. The aim of this study was to examine the effect of orange juice (OJ) or OJ beverage (Bev) alone and fortified with plant sterols (1g/240 ml juice or beverage twice a day) on pro-inflammatory cytokines and PAI-1, a marker of impaired fibrinolysis in healthy human volunteers.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><noCountry><name sortKey="Jialal, Ishwarlal" sort="Jialal, Ishwarlal" uniqKey="Jialal I" first="Ishwarlal" last="Jialal">Ishwarlal Jialal</name><name sortKey="Rockwood, Jason" sort="Rockwood, Jason" uniqKey="Rockwood J" first="Jason" last="Rockwood">Jason Rockwood</name><name sortKey="Zak, Danielle" sort="Zak, Danielle" uniqKey="Zak D" first="Danielle" last="Zak">Danielle Zak</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Devaraj, Sridevi" sort="Devaraj, Sridevi" uniqKey="Devaraj S" first="Sridevi" last="Devaraj">Sridevi Devaraj</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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