Insights into the evolution and domain structure of ataxin-2 proteins across eukaryotes
Identifieur interne : 000A26 ( Main/Exploration ); précédent : 000A25; suivant : 000A27Insights into the evolution and domain structure of ataxin-2 proteins across eukaryotes
Auteurs : Domingo Jiménez-L Pez [Mexique] ; Plinio Guzmán [Mexique]Source :
- BMC Research Notes [ 1756-0500 ] ; 2014.
Abstract
Ataxin-2 is an evolutionarily conserved protein first identified in humans as responsible for spinocerebellar ataxia type 2 (SCA2). The molecular basis of SCA2 is the expansion of a polyglutamine tract in Ataxin-2, encoding a Lsm domain that may bind RNA and a PAM2 motif that enables interaction with the poly (A) binding protein. Although the association with SCA2 has been verified, a detailed molecular function for Ataxin-2 has not been established.
We have undertaken a survey of Ataxin-2 proteins across all eukaryotic domains. In eukaryotes, except for vertebrates and land plants, a single ortholog was identified. Notably, with the exception of birds, two Ataxin-2 genes exist in vertebrates. Expansion was observed in land plants and a novel class lacking the LsmAD domain was identified. Large polyQ tracts appear limited to primates and insects of the orders Hymenoptera and Diptera. A common feature across Ataxin-2 orthologs is the presence of proline-rich motifs, formerly described in the human protein.
Our analysis provides valuable information on the evolution and domain structure of Ataxin-2 proteins. Proline-rich motifs that may mediate protein interactions are widespread in Ataxin-2 proteins, but expansion of polyglutamine tracts associated with spinocerebellar ataxia type 2, is present only in primates, as well as some insects. Our analysis of Ataxin-2 proteins provides also a source to examine orthologs in a number of different species.
Url:
DOI: 10.1186/1756-0500-7-453
PubMed: 25027299
PubMed Central: 4105795
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Insights into the evolution and domain structure of ataxin-2 proteins across eukaryotes</title><author><name sortKey="Jimenez L Pez, Domingo" sort="Jimenez L Pez, Domingo" uniqKey="Jimenez L Pez D" first="Domingo" last="Jiménez-L Pez">Domingo Jiménez-L Pez</name><affiliation wicri:level="1"><nlm:aff id="I1">Departamento de Ingeniería Genética, Centro de Investigación y de Estudios Avanzados, Unidad Irapuato, Apartado Postal 629, Irapuato, Gto 36821, México</nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Ingeniería Genética, Centro de Investigación y de Estudios Avanzados, Unidad Irapuato, Apartado Postal 629, Irapuato, Gto 36821</wicri:regionArea><wicri:noRegion>Gto 36821</wicri:noRegion></affiliation></author><author><name sortKey="Guzman, Plinio" sort="Guzman, Plinio" uniqKey="Guzman P" first="Plinio" last="Guzmán">Plinio Guzmán</name><affiliation wicri:level="1"><nlm:aff id="I1">Departamento de Ingeniería Genética, Centro de Investigación y de Estudios Avanzados, Unidad Irapuato, Apartado Postal 629, Irapuato, Gto 36821, México</nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Ingeniería Genética, Centro de Investigación y de Estudios Avanzados, Unidad Irapuato, Apartado Postal 629, Irapuato, Gto 36821</wicri:regionArea><wicri:noRegion>Gto 36821</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25027299</idno><idno type="pmc">4105795</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105795</idno><idno type="RBID">PMC:4105795</idno><idno type="doi">10.1186/1756-0500-7-453</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000B58</idno><idno type="wicri:Area/Pmc/Curation">000B57</idno><idno type="wicri:Area/Pmc/Checkpoint">000777</idno><idno type="wicri:Area/Ncbi/Merge">001764</idno><idno type="wicri:Area/Ncbi/Curation">001764</idno><idno type="wicri:Area/Ncbi/Checkpoint">001764</idno><idno type="wicri:Area/Main/Merge">000A27</idno><idno type="wicri:Area/Main/Curation">000A26</idno><idno type="wicri:Area/Main/Exploration">000A26</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Insights into the evolution and domain structure of ataxin-2 proteins across eukaryotes</title><author><name sortKey="Jimenez L Pez, Domingo" sort="Jimenez L Pez, Domingo" uniqKey="Jimenez L Pez D" first="Domingo" last="Jiménez-L Pez">Domingo Jiménez-L Pez</name><affiliation wicri:level="1"><nlm:aff id="I1">Departamento de Ingeniería Genética, Centro de Investigación y de Estudios Avanzados, Unidad Irapuato, Apartado Postal 629, Irapuato, Gto 36821, México</nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Ingeniería Genética, Centro de Investigación y de Estudios Avanzados, Unidad Irapuato, Apartado Postal 629, Irapuato, Gto 36821</wicri:regionArea><wicri:noRegion>Gto 36821</wicri:noRegion></affiliation></author><author><name sortKey="Guzman, Plinio" sort="Guzman, Plinio" uniqKey="Guzman P" first="Plinio" last="Guzmán">Plinio Guzmán</name><affiliation wicri:level="1"><nlm:aff id="I1">Departamento de Ingeniería Genética, Centro de Investigación y de Estudios Avanzados, Unidad Irapuato, Apartado Postal 629, Irapuato, Gto 36821, México</nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Ingeniería Genética, Centro de Investigación y de Estudios Avanzados, Unidad Irapuato, Apartado Postal 629, Irapuato, Gto 36821</wicri:regionArea><wicri:noRegion>Gto 36821</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Research Notes</title><idno type="eISSN">1756-0500</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Ataxin-2 is an evolutionarily conserved protein first identified in humans as responsible for spinocerebellar ataxia type 2 (SCA2). The molecular basis of SCA2 is the expansion of a polyglutamine tract in Ataxin-2, encoding a Lsm domain that may bind RNA and a PAM2 motif that enables interaction with the poly (A) binding protein. Although the association with SCA2 has been verified, a detailed molecular function for Ataxin-2 has not been established.</p></sec><sec><title>Results</title><p>We have undertaken a survey of Ataxin-2 proteins across all eukaryotic domains. In eukaryotes, except for vertebrates and land plants, a single ortholog was identified. Notably, with the exception of birds, two Ataxin-2 genes exist in vertebrates. Expansion was observed in land plants and a novel class lacking the LsmAD domain was identified. Large polyQ tracts appear limited to primates and insects of the orders Hymenoptera and Diptera. A common feature across Ataxin-2 orthologs is the presence of proline-rich motifs, formerly described in the human protein.</p></sec><sec><title>Conclusion</title><p>Our analysis provides valuable information on the evolution and domain structure of Ataxin-2 proteins. Proline-rich motifs that may mediate protein interactions are widespread in Ataxin-2 proteins, but expansion of polyglutamine tracts associated with spinocerebellar ataxia type 2, is present only in primates, as well as some insects. Our analysis of Ataxin-2 proteins provides also a source to examine orthologs in a number of different species.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lastres Becker, I" uniqKey="Lastres Becker I">I Lastres-Becker</name></author><author><name sortKey="Rub, U" uniqKey="Rub U">U Rüb</name></author><author><name sortKey="Auburger, G" uniqKey="Auburger G">G Auburger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tharun, S" uniqKey="Tharun S">S Tharun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neuwald, Af" uniqKey="Neuwald A">AF Neuwald</name></author><author><name sortKey="Koonin, Ev" uniqKey="Koonin E">EV Koonin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bannykh, Si" uniqKey="Bannykh S">SI Bannykh</name></author><author><name sortKey="Nishimura, N" uniqKey="Nishimura N">N 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H">H Shimodaira</name></author><author><name sortKey="Hasegawa, M" uniqKey="Hasegawa M">M Hasegawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aguilar Hernandez, V" uniqKey="Aguilar Hernandez V">V Aguilar-Hernandez</name></author><author><name sortKey="Medina, J" uniqKey="Medina J">J Medina</name></author><author><name sortKey="Aguilar Henonin, L" uniqKey="Aguilar Henonin L">L Aguilar-Henonin</name></author><author><name sortKey="Guzman, P" uniqKey="Guzman P">P Guzman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Federhen, S" uniqKey="Federhen S">S Federhen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Letunic, I" uniqKey="Letunic I">I Letunic</name></author><author><name sortKey="Bork, P" uniqKey="Bork P">P Bork</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bailey, Tl" uniqKey="Bailey T">TL Bailey</name></author><author><name sortKey="Boden, M" uniqKey="Boden M">M Boden</name></author><author><name sortKey="Buske, Fa" uniqKey="Buske F">FA Buske</name></author><author><name sortKey="Frith, M" uniqKey="Frith M">M Frith</name></author><author><name sortKey="Grant, Ce" uniqKey="Grant C">CE Grant</name></author><author><name sortKey="Clementi, L" uniqKey="Clementi L">L Clementi</name></author><author><name sortKey="Ren, J" uniqKey="Ren J">J Ren</name></author><author><name sortKey="Li, Ww" uniqKey="Li W">WW Li</name></author><author><name sortKey="Noble, Ws" uniqKey="Noble W">WS Noble</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Mexique</li></country></list><tree><country name="Mexique"><noRegion><name sortKey="Jimenez L Pez, Domingo" sort="Jimenez L Pez, Domingo" uniqKey="Jimenez L Pez D" first="Domingo" last="Jiménez-L Pez">Domingo Jiménez-L Pez</name></noRegion><name sortKey="Guzman, Plinio" sort="Guzman, Plinio" uniqKey="Guzman P" first="Plinio" 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