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Riboswitch Control of Gene Expression in Plants by Splicing and Alternative 3′ End Processing of mRNAs[W][OA]

Identifieur interne : 002274 ( Main/Exploration ); précédent : 002273; suivant : 002275

Riboswitch Control of Gene Expression in Plants by Splicing and Alternative 3′ End Processing of mRNAs[W][OA]

Auteurs : Andreas Wachter [États-Unis] ; Meral Tunc-Ozdemir [États-Unis] ; Beth C. Grove [États-Unis] ; Pamela J. Green [États-Unis] ; David K. Shintani [États-Unis] ; Ronald R. Breaker [États-Unis]

Source :

The Plant Cell [ 1040-4651 ] ; 2007.

RBID : PMC:2174889

Abstract

The most widespread riboswitch class, found in organisms from all three domains of life, is responsive to the vitamin B₁ derivative thiamin pyrophosphate (TPP). We have established that a TPP-sensing riboswitch is present in the 3′ untranslated region (UTR) of the thiamin biosynthetic gene THIC of all plant species examined. The THIC TPP riboswitch controls the formation of transcripts with alternative 3′ UTR lengths, which affect mRNA accumulation and protein production. We demonstrate that riboswitch-mediated regulation of alternative 3′ end processing is critical for TPP-dependent feedback control of THIC expression. Our data reveal a mechanism whereby metabolite-dependent alteration of RNA folding controls splicing and alternative 3′ end processing of mRNAs. These findings highlight the importance of metabolite sensing by riboswitches in plants and further reveal the significance of alternative 3′ end processing as a mechanism of gene control in eukaryotes.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174889

DOI: 10.1105/tpc.107.053645
PubMed: 17993623
PubMed Central: 2174889

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>The most widespread riboswitch class, found in organisms from all three domains of life, is responsive to the vitamin B<sub>1</sub>
 derivative thiamin pyrophosphate (TPP). We have established that a TPP-sensing riboswitch is present in the 3′ untranslated region (UTR) of the thiamin biosynthetic gene <italic>THIC</italic>
 of all plant species examined. The <italic>THIC</italic>
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 expression. Our data reveal a mechanism whereby metabolite-dependent alteration of RNA folding controls splicing and alternative 3′ end processing of mRNAs. These findings highlight the importance of metabolite sensing by riboswitches in plants and further reveal the significance of alternative 3′ end processing as a mechanism of gene control in eukaryotes.</p>
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Riboswitch Control of Gene Expression in Plants by Splicing and Alternative 3′ End Processing of mRNAs[W][OA]

Riboswitch Control of Gene Expression in Plants by Splicing and Alternative 3′ End Processing of mRNAs[W][OA]

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Abstract

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