In Vitro Antiplasmodial Activities and Synergistic Combinations of Differential Solvent Extracts of the Polyherbal Product, Nefang
Identifieur interne : 000C35 ( Main/Exploration ); précédent : 000C34; suivant : 000C36In Vitro Antiplasmodial Activities and Synergistic Combinations of Differential Solvent Extracts of the Polyherbal Product, Nefang
Auteurs : Protus Arrey Tarkang [Cameroun, Kenya] ; Kathrin Diehl Franzoi [Corée du Sud] ; Sukjun Lee [Corée du Sud] ; Eunyoung Lee [Corée du Sud] ; Diego Vivarelli [Corée du Sud] ; Lucio Freitas-Junior [Corée du Sud] ; Michel Liuzzi [Corée du Sud] ; Tsabang Nolé [Cameroun] ; Lawrence S. Ayong [Corée du Sud] ; Gabriel A. Agbor [Cameroun] ; Faith A. Okalebo [Kenya] ; Anastasia N. Guantai [Kenya]Source :
- BioMed Research International [ 2314-6133 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Antimalarials, Plant Extracts, Solvents.
- chemical , pharmacology : Antimalarials, Plant Extracts.
- drug therapy : Malaria, Falciparum.
- Drug Evaluation, Preclinical, Hep G2 Cells, Humans, Plasmodium falciparum.
Abstract
Url:
DOI: 10.1155/2014/835013
PubMed: 24877138
PubMed Central: 4022163
Affiliations:
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Le document en format XML
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Antiplasmodial Activities and Synergistic Combinations of Differential Solvent Extracts of the Polyherbal Product, <italic>Nefang</italic>
</title>
<author><name sortKey="Arrey Tarkang, Protus" sort="Arrey Tarkang, Protus" uniqKey="Arrey Tarkang P" first="Protus" last="Arrey Tarkang">Protus Arrey Tarkang</name>
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<country xml:lang="fr">Cameroun</country>
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<affiliation wicri:level="1"><nlm:aff id="I2">Department of Pharmacology and Pharmacognosy, University of Nairobi, P.O. Box 19676-00202, Nairobi 0800, Kenya</nlm:aff>
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<author><name sortKey="Freitas Junior, Lucio" sort="Freitas Junior, Lucio" uniqKey="Freitas Junior L" first="Lucio" last="Freitas-Junior">Lucio Freitas-Junior</name>
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<author><name sortKey="Liuzzi, Michel" sort="Liuzzi, Michel" uniqKey="Liuzzi M" first="Michel" last="Liuzzi">Michel Liuzzi</name>
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<author><name sortKey="Nole, Tsabang" sort="Nole, Tsabang" uniqKey="Nole T" first="Tsabang" last="Nolé">Tsabang Nolé</name>
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<author><name sortKey="Ayong, Lawrence S" sort="Ayong, Lawrence S" uniqKey="Ayong L" first="Lawrence S." last="Ayong">Lawrence S. Ayong</name>
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<author><name sortKey="Okalebo, Faith A" sort="Okalebo, Faith A" uniqKey="Okalebo F" first="Faith A." last="Okalebo">Faith A. Okalebo</name>
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<author><name sortKey="Guantai, Anastasia N" sort="Guantai, Anastasia N" uniqKey="Guantai A" first="Anastasia N." last="Guantai">Anastasia N. Guantai</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>In Vitro</italic>
Antiplasmodial Activities and Synergistic Combinations of Differential Solvent Extracts of the Polyherbal Product, <italic>Nefang</italic>
</title>
<author><name sortKey="Arrey Tarkang, Protus" sort="Arrey Tarkang, Protus" uniqKey="Arrey Tarkang P" first="Protus" last="Arrey Tarkang">Protus Arrey Tarkang</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies (IMPM), P.O. Box 6163, Yaoundé, Cameroon</nlm:aff>
<country xml:lang="fr">Cameroun</country>
<wicri:regionArea>Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies (IMPM), P.O. Box 6163, Yaoundé</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I2">Department of Pharmacology and Pharmacognosy, University of Nairobi, P.O. Box 19676-00202, Nairobi 0800, Kenya</nlm:aff>
<country xml:lang="fr">Kenya</country>
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<author><name sortKey="Franzoi, Kathrin Diehl" sort="Franzoi, Kathrin Diehl" uniqKey="Franzoi K" first="Kathrin Diehl" last="Franzoi">Kathrin Diehl Franzoi</name>
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<author><name sortKey="Lee, Sukjun" sort="Lee, Sukjun" uniqKey="Lee S" first="Sukjun" last="Lee">Sukjun Lee</name>
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<author><name sortKey="Lee, Eunyoung" sort="Lee, Eunyoung" uniqKey="Lee E" first="Eunyoung" last="Lee">Eunyoung Lee</name>
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<author><name sortKey="Vivarelli, Diego" sort="Vivarelli, Diego" uniqKey="Vivarelli D" first="Diego" last="Vivarelli">Diego Vivarelli</name>
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<country xml:lang="fr">Corée du Sud</country>
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<author><name sortKey="Freitas Junior, Lucio" sort="Freitas Junior, Lucio" uniqKey="Freitas Junior L" first="Lucio" last="Freitas-Junior">Lucio Freitas-Junior</name>
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<country xml:lang="fr">Corée du Sud</country>
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</affiliation>
</author>
<author><name sortKey="Liuzzi, Michel" sort="Liuzzi, Michel" uniqKey="Liuzzi M" first="Michel" last="Liuzzi">Michel Liuzzi</name>
<affiliation wicri:level="1"><nlm:aff id="I3">Early Drug Discovery Program, Institut Pasteur Korea, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Early Drug Discovery Program, Institut Pasteur Korea</wicri:regionArea>
<wicri:noRegion>Institut Pasteur Korea</wicri:noRegion>
</affiliation>
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<author><name sortKey="Nole, Tsabang" sort="Nole, Tsabang" uniqKey="Nole T" first="Tsabang" last="Nolé">Tsabang Nolé</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies (IMPM), P.O. Box 6163, Yaoundé, Cameroon</nlm:aff>
<country xml:lang="fr">Cameroun</country>
<wicri:regionArea>Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies (IMPM), P.O. Box 6163, Yaoundé</wicri:regionArea>
<wicri:noRegion>Yaoundé</wicri:noRegion>
</affiliation>
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<author><name sortKey="Ayong, Lawrence S" sort="Ayong, Lawrence S" uniqKey="Ayong L" first="Lawrence S." last="Ayong">Lawrence S. Ayong</name>
<affiliation wicri:level="1"><nlm:aff id="I3">Early Drug Discovery Program, Institut Pasteur Korea, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Early Drug Discovery Program, Institut Pasteur Korea</wicri:regionArea>
<wicri:noRegion>Institut Pasteur Korea</wicri:noRegion>
</affiliation>
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<author><name sortKey="Agbor, Gabriel A" sort="Agbor, Gabriel A" uniqKey="Agbor G" first="Gabriel A." last="Agbor">Gabriel A. Agbor</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies (IMPM), P.O. Box 6163, Yaoundé, Cameroon</nlm:aff>
<country xml:lang="fr">Cameroun</country>
<wicri:regionArea>Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies (IMPM), P.O. Box 6163, Yaoundé</wicri:regionArea>
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</affiliation>
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<author><name sortKey="Okalebo, Faith A" sort="Okalebo, Faith A" uniqKey="Okalebo F" first="Faith A." last="Okalebo">Faith A. Okalebo</name>
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<country xml:lang="fr">Kenya</country>
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</affiliation>
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<author><name sortKey="Guantai, Anastasia N" sort="Guantai, Anastasia N" uniqKey="Guantai A" first="Anastasia N." last="Guantai">Anastasia N. Guantai</name>
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<term>Antimalarials (pharmacology)</term>
<term>Drug Evaluation, Preclinical</term>
<term>Hep G2 Cells</term>
<term>Humans</term>
<term>Malaria, Falciparum (drug therapy)</term>
<term>Plant Extracts (chemistry)</term>
<term>Plant Extracts (pharmacology)</term>
<term>Plasmodium falciparum</term>
<term>Solvents (chemistry)</term>
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<term>Solvents</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antimalarials</term>
<term>Plant Extracts</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Malaria, Falciparum</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Drug Evaluation, Preclinical</term>
<term>Hep G2 Cells</term>
<term>Humans</term>
<term>Plasmodium falciparum</term>
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<front><div type="abstract" xml:lang="en"><p><italic>Nefang</italic>
, a polyherbal product composed of <italic>Mangifera indica</italic>
(bark and leaf), <italic>Psidium guajava</italic>
, <italic>Carica papaya</italic>
, <italic>Cymbopogon citratus</italic>
, <italic>Citrus sinensis</italic>
, and <italic>Ocimum gratissimum</italic>
(leaves), is a potential therapy against <italic>P. falciparum</italic>
malaria. <italic>In vitro</italic>
antiplasmodial activities of its constituent solvent extracts were analyzed on CQ-sensitive (3D7) and multidrug resistant (Dd2) <italic>P. falciparum</italic>
strains. The interactions involving the differential solvent extracts were further analyzed using a variable potency ratio drug combination approach. Effective concentration 50 (EC<sub>50</sub>
) values were determined by nonlinear regression curve-fitting of the dose-response data and used in calculating the fractional inhibitory concentration 50 (FIC<sub>50</sub>
) and combination indices (CI) for each pair. The derived EC<sub>50</sub>
values (3D7/Dd2, <italic><italic>μ</italic>
</italic>
g/mL) are <italic>Nefang</italic>
-96.96/55.08, <italic>MiB</italic>
-65.33/34.58, <italic>MiL</italic>
-82.56/40.04, <italic>Pg</italic>
-47.02/25.79, <italic>Cp</italic>
-1188/317.5, <italic>Cc</italic>
-723.3/141, <italic>Cs</italic>
-184.4/105.1, and <italic>Og</italic>
-778.5/118.9. Synergism was obtained with <italic>MiB/Pg</italic>
(CI = 0.351), <italic>MiL/Pg</italic>
(0.358), <italic>MiB/Cs</italic>
(0.366), <italic>MiL/Cs</italic>
(0.482), <italic>Pg/Cs</italic>
(0.483), and <italic>Cs/Og</italic>
(0.414) when analyzed at equipotency ratios. Cytotoxicity testing of <italic>Nefang</italic>
and the solvent extracts on two human cell lines (Hep G2 and U2OS) revealed no significant toxicity relative to their antiplasmodial activities (SI > 20). Taken together, our data confirm the antimalarial activities of <italic>Nefang</italic>
and its
constituent plant extracts and identified extract pairs with promising synergistic interactions for exploitation towards a rational phytotherapeutic and evidence-based antimalarial drug discovery.</p>
</div>
</front>
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