Engineered Biosynthesis of Natural Products in Heterologous Hosts
Identifieur interne : 000663 ( Main/Exploration ); précédent : 000662; suivant : 000664Engineered Biosynthesis of Natural Products in Heterologous Hosts
Auteurs : Yunzi Luo [République populaire de Chine, États-Unis] ; Bing-Zhi Li [République populaire de Chine] ; Duo Liu [République populaire de Chine] ; Lu Zhang [République populaire de Chine] ; Yan Chen [République populaire de Chine] ; Bin Jia [République populaire de Chine] ; Bo-Xuan Zeng [République populaire de Chine] ; Huimin Zhao [États-Unis] ; Ying-Jin Yuan [République populaire de Chine]Source :
- Chemical Society reviews [ 0306-0012 ] ; 2015.
Abstract
Natural products produced by microorganisms and plants are a major resource of antibacterial and anticancer drugs as well as industrially useful compounds. However, the native producers often suffer from low productivity and titers. Here we summarize the recent applications of heterologous biosynthesis for the production of several important classes of natural products such as terpenoids, flavonoids, alkaloids, and polyketides. In addition, we will discuss the new tools and strategies at multi-scale levels including gene, pathway, genome and community levels for highly efficient heterologous biosynthesis of natural products.
Url:
DOI: 10.1039/c5cs00025d
PubMed: 25960127
PubMed Central: 4510016
Affiliations:
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xml:lang="en" level="a" type="main">Engineered Biosynthesis of Natural Products in Heterologous Hosts</title><author><name sortKey="Luo, Yunzi" sort="Luo, Yunzi" uniqKey="Luo Y" first="Yunzi" last="Luo">Yunzi Luo</name><affiliation wicri:level="1"><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072</wicri:regionArea><wicri:noRegion>300072</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Department of Chemical and Biomolecular Engineering and Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 600 South Mathews Ave, Urbana, IL 61801, United States.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Chemical and Biomolecular Engineering and Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 600 South Mathews Ave, Urbana, IL 61801</wicri:regionArea><wicri:noRegion>IL 61801</wicri:noRegion></affiliation></author><author><name sortKey="Li, Bing Zhi" sort="Li, Bing Zhi" uniqKey="Li B" first="Bing-Zhi" last="Li">Bing-Zhi Li</name><affiliation wicri:level="1"><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072</wicri:regionArea><wicri:noRegion>300072</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072</wicri:regionArea><wicri:noRegion>300072</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Duo" sort="Liu, Duo" uniqKey="Liu D" first="Duo" last="Liu">Duo Liu</name><affiliation wicri:level="1"><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072</wicri:regionArea><wicri:noRegion>300072</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072</wicri:regionArea><wicri:noRegion>300072</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Lu" sort="Zhang, Lu" uniqKey="Zhang L" first="Lu" last="Zhang">Lu Zhang</name><affiliation wicri:level="1"><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072</wicri:regionArea><wicri:noRegion>300072</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072</wicri:regionArea><wicri:noRegion>300072</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name><affiliation wicri:level="1"><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072</wicri:regionArea><wicri:noRegion>300072</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072</wicri:regionArea><wicri:noRegion>300072</wicri:noRegion></affiliation></author><author><name sortKey="Jia, Bin" sort="Jia, Bin" uniqKey="Jia B" first="Bin" last="Jia">Bin Jia</name><affiliation wicri:level="1"><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072</wicri:regionArea><wicri:noRegion>300072</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072</wicri:regionArea><wicri:noRegion>300072</wicri:noRegion></affiliation></author><author><name sortKey="Zeng, Bo Xuan" sort="Zeng, Bo Xuan" uniqKey="Zeng B" first="Bo-Xuan" last="Zeng">Bo-Xuan Zeng</name><affiliation wicri:level="1"><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072</wicri:regionArea><wicri:noRegion>300072</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072</wicri:regionArea><wicri:noRegion>300072</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Huimin" sort="Zhao, Huimin" uniqKey="Zhao H" first="Huimin" last="Zhao">Huimin Zhao</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Chemical and Biomolecular Engineering and Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 600 South Mathews Ave, Urbana, IL 61801, United States.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Chemical and Biomolecular Engineering and Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 600 South Mathews Ave, Urbana, IL 61801</wicri:regionArea><wicri:noRegion>IL 61801</wicri:noRegion></affiliation></author><author><name sortKey="Yuan, Ying Jin" sort="Yuan, Ying Jin" uniqKey="Yuan Y" first="Ying-Jin" last="Yuan">Ying-Jin Yuan</name><affiliation wicri:level="1"><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072</wicri:regionArea><wicri:noRegion>300072</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072</wicri:regionArea><wicri:noRegion>300072</wicri:noRegion></affiliation></author></analytic><series><title level="j">Chemical Society reviews</title><idno type="ISSN">0306-0012</idno><idno type="eISSN">1460-4744</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P3">Natural products produced by microorganisms and plants are a major resource of antibacterial and anticancer drugs as well as industrially useful compounds. However, the native producers often suffer from low productivity and titers. Here we summarize the recent applications of heterologous biosynthesis for the production of several important classes of natural products such as terpenoids, flavonoids, alkaloids, and polyketides. In addition, we will discuss the new tools and strategies at multi-scale levels including gene, pathway, genome and community levels for highly efficient heterologous biosynthesis of natural products.</p></div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Luo, Yunzi" sort="Luo, Yunzi" uniqKey="Luo Y" first="Yunzi" last="Luo">Yunzi Luo</name></noRegion><name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name><name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name><name sortKey="Jia, Bin" sort="Jia, Bin" uniqKey="Jia B" first="Bin" last="Jia">Bin Jia</name><name sortKey="Jia, Bin" sort="Jia, Bin" uniqKey="Jia B" first="Bin" last="Jia">Bin Jia</name><name sortKey="Li, Bing Zhi" sort="Li, Bing Zhi" uniqKey="Li B" first="Bing-Zhi" last="Li">Bing-Zhi Li</name><name sortKey="Li, Bing Zhi" sort="Li, Bing Zhi" uniqKey="Li B" first="Bing-Zhi" last="Li">Bing-Zhi Li</name><name sortKey="Liu, Duo" sort="Liu, Duo" uniqKey="Liu D" first="Duo" last="Liu">Duo Liu</name><name sortKey="Liu, Duo" sort="Liu, Duo" uniqKey="Liu D" first="Duo" last="Liu">Duo Liu</name><name sortKey="Yuan, Ying Jin" sort="Yuan, Ying Jin" uniqKey="Yuan Y" first="Ying-Jin" last="Yuan">Ying-Jin Yuan</name><name sortKey="Yuan, Ying Jin" sort="Yuan, Ying Jin" uniqKey="Yuan Y" first="Ying-Jin" last="Yuan">Ying-Jin Yuan</name><name sortKey="Zeng, Bo Xuan" sort="Zeng, Bo Xuan" uniqKey="Zeng B" first="Bo-Xuan" last="Zeng">Bo-Xuan Zeng</name><name sortKey="Zeng, Bo Xuan" sort="Zeng, Bo Xuan" uniqKey="Zeng B" first="Bo-Xuan" last="Zeng">Bo-Xuan Zeng</name><name sortKey="Zhang, Lu" sort="Zhang, Lu" uniqKey="Zhang L" first="Lu" last="Zhang">Lu Zhang</name><name sortKey="Zhang, Lu" sort="Zhang, Lu" uniqKey="Zhang L" first="Lu" last="Zhang">Lu Zhang</name></country><country name="États-Unis"><noRegion><name sortKey="Luo, Yunzi" sort="Luo, Yunzi" uniqKey="Luo Y" first="Yunzi" last="Luo">Yunzi Luo</name></noRegion><name sortKey="Zhao, Huimin" sort="Zhao, Huimin" uniqKey="Zhao H" first="Huimin" last="Zhao">Huimin Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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